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Journal articles on the topic 'Keratoacanthomas'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Schaller, M., HC Korting, H. Wolff, CG Schirren, and W. Burgdorf. "Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin." Acta Dermato-Venereologica 76, no. 1 (1996): 40–42. http://dx.doi.org/10.2340/00015555764042.

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A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybridisation revealed no human papilloma virus in the tumours. Complete examination showed no associated internal malignancy. After repeated surgical treatment oral isotretinoin treatment was administered (1 mg/kg per day). This treatment produced clearing of existing keratoacanthomas

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2

Krunic, AL, DR Garrod, NP Smith, GS Orchard, and OB Cvijetic. "Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis." Acta Dermato-Venereologica 76, no. 5 (1996): 394–98. http://dx.doi.org/10.2340/0001555576394398.

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The distinction between keratoacanthoma and squamous cell carcinoma is a common dermatopathological dilemma. Although the mainstay of the diagnosis is still clinico-pathological correlation, many dermatopathologists now include keratoacanthomas in the spectrum of squamous cell carcinomas. Recent reports, however, have pointed out that keratoacanthoma is "deficient squamous cell carcinoma" since it loses the expression of bcl-2 antigen, consistent with initiation of apoptosis, i.e. its involution. Electron microscope studies performed in keratoacanthomas and squamous cell carcinomas also reveal

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3

Craddock, Kenneth J., Jaggi Rao, Gilles J. Lauzon, and Victor A. Tron. "Multiple Keratoacanthomas Arising Post-UVB Therapy." Journal of Cutaneous Medicine and Surgery 8, no. 4 (2004): 239–43. http://dx.doi.org/10.1177/120347540400800407.

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Background: Ultraviolet (UV) radiation is known to be an important etiologic agent in the development of skin cancer. Keratoacanthoma is an unusual, well-described cutaneous neoplasm that resembes squamous cell carcinoma but spontaneously resolves. Rarely, multiple keratoacanthomas may develop. Objective We present a case of multiple keratoacanthomas in a patient with psoriasis who had received UVB phototherapy. These lesions were hyperkeratotic papules, many of which spontaneously resolved and demonstrated the histologic characteristics of keratoacanthoma. Conclusion: We believe that UV radia

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4

Austin, Publishing Group. "Keratoacanthomas Induced by Cat Scratches in an Elderly Woman." Austin Journal of Clinical Case Reports 8, no. 2 (2021): 1197. https://doi.org/10.26420/austinjclincaserep.2021.1197.

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Abstract <strong>Background:</strong> Keratoacanthomas (KAs) are relatively common self-limited squamous proliferations. It is a matter of debate, whether they are a variant of squamous cell carcinoma or benign neoplasms. The exact etiology is uncertain, but is believed to be multifactorial, and is reportedly associated with trauma. This report describes an elderly woman with multiple keratoacanthomas developing at sites scratched by a pet cat. <strong>Methods:</strong> A case of a 92-year-old woman with Alzheimer’s disease, presented with multiple rapidly growing, bizarre look

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5

Ilaria, Proietti, Skroza Nevena, Tolino Ersilia, et al. "Generalized Eruptive Keratoacanthoma (GEKA) after Pfizer mRNABNT162b2 (Comirnaty®) COVID-19 Vaccination Successfully Treated with Cemiplimab." Viruses 16, no. 8 (2024): 1260. http://dx.doi.org/10.3390/v16081260.

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In December 2020, a major vaccination program against COVID-19 commenced in Europe with vaccines such as Pfizer’s mRNABNT162b2 (Comirnaty®). Subsequent reports of immediate and delayed skin reactions emerged. This study presents a case of a 64-year-old male who developed multiple keratoacanthomas approximately two weeks after receiving a second booster dose of the Pfizer vaccine. The patient, who had significant medical history of hypertension and diabetes, presented with erythematous, crateriform lesions on his limbs. A physical examination and histopathological analysis confirmed the diagnos

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6

Thukral, Siddhant, Lloyd E. King Jr, Lloyd E. King Jr, and David H. Horowitz. "Multiple Keratoacanthomas, Philadelphia Chromosome+ Acute Lymphoblastic Leukemia, and Dasatinib: A Case Report." International Journal of Medical Students 3, no. 3 (2015): 155–58. http://dx.doi.org/10.5195/ijms.2015.137.

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Background: Treatment for adult Philadelphia chromosome+ acute lymphoblastic leukemia includes using dasatinib, a tyrosine kinase inhibitor. Cutaneous squamous cell carcinomas and keratoacanthomas are common findings in patients treated with BRAF inhibitors of tyrosine kinases. No documentation of dasatinib inducing multiple keratoacanthomas, squamous cell carcinomas type during treatment of Philadelphia chromosome+ acute lymphoblastic leukemia is currently available. Case: A 77-year-old Caucasian male presented to the dermatology clinic two months after starting treatment with dasatinib for P

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7

McGlashan, J. A., G. Rees, and D. A. Bowdler. "Solitary keratoacanthoma of the nasal vestibule." Journal of Laryngology & Otology 105, no. 4 (1991): 306–8. http://dx.doi.org/10.1017/s0022215100115701.

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AbstractKeratoacanthomas are lesions which rarely present to Otorhinolaryngologists; however they must be considered in the differential diagnosis of any rapidly growing lesion in the head and neck. We report a case of a keratoacanthoma of the nasal vestibule which caused clinical and histopathological difficulties in diagnosis. Keratoacanthomas and the treatment options are discussed.

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8

Karampinis, Emmanouil, Christina Kostopoulou, Olga Toli, et al. "Multiple Keratoacanthoma-like Syndromes: Case Report and Literature Review." Medicina 60, no. 3 (2024): 371. http://dx.doi.org/10.3390/medicina60030371.

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Keratoacanthoma (KA) is a fast-growing skin tumor subtype that can be observed as a solitary lesion or rarely as multiple lesions in the context of rare genetic syndromes. Syndromes with multiple keratoacanthoma-like lesions have been documented as multiple self-healing squamous epithelioma (Ferguson–Smith syndrome), eruptive keratoacanthoma of Grzybowski, multiple familial keratoacanthoma of Witten and Zak Muir–Torre syndrome, and incontinentia pigmenti. The treatment approach of those entities is challenging due to the numerous lesions, the lesions’ undefined nature, and the co-existence of

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9

Singleton, Kathleen M., Steven F. Morris, and Arnis Freiberg. "Keratoacanthoma in the Immunocompromised Patient - Surgical Concerns." Canadian Journal of Plastic Surgery 2, no. 3 (1994): 108–12. http://dx.doi.org/10.1177/229255039400200305.

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KM Singleton, SF Morris, a Freiberg. Keratoacanthoma in the immunocompromised patient - Surgical concerns. Can J Plast Surg 1994;2(3): 108-112. It is well known that clinical and histological differentiation between keratoacanthoma and squamous cell carcinoma is often difficult. The two lesions share many common features, but have very different outcomes. Both occur with increased frequency in immunosuppressed patients. This report documents two cases of histologically confirmed keratoacanthoma in immunosuppressed patients. These lesions were excised but had frequent recurrences and in both ca

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10

Lindsay, Daniel P., Jordan Kharofa, Marianne Junck, Edit Olasz, and J. Frank Wilson. "Eruptive keratoacanthomas after radiation therapy for keratoacanthoma centrifugum marginatum." Practical Radiation Oncology 5, no. 3 (2015): 203–6. http://dx.doi.org/10.1016/j.prro.2014.10.011.

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11

LiVolsi, Virginia A. "Keratoacanthomas." American Journal of Dermatopathology 16, no. 3 (1994): 346. http://dx.doi.org/10.1097/00000372-199406000-00020.

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12

Gönül, M., SK Cakmak, A. Kiliç, S. Artantas, U. Gül, and AO Heper. "A case of multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum." Acta Dermato-Venereologica 86, no. 2 (2006): 169–70. http://dx.doi.org/10.2340/00015555-0023.

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13

Lee, Joo Heon, and Joo Heon Roh. "Upper Eyelid Keratoacanthoma with a Cutaneous Horn." Journal of the Korean Ophthalmological Society 63, no. 11 (2022): 942–46. http://dx.doi.org/10.3341/jkos.2022.63.11.942.

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Purpose: To report a case of upper eyelid keratoacanthoma with a cutaneous horn.Case summary: A 59-year-old female presented to our clinic with a rapidly growing, painless mass in the center of the right upper eyelid. A 2 × 2 × 5 mm dark brown conical hyperkeratotic mass and a 7 × 4 mm nodular, nontender mass were palpable on the right upper eyelid. The lesion was isolated from the surrounding tissues and excised completely. Histopathologically, the excised masses showed parakeratosis along with hyperkeratosis of the conical mass and the keratin plug, keratin pearls, and epithelial proliferati

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14

Leon, J., H. Kamino, J. J. Steinberg, and A. Pellicer. "H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system." Molecular and Cellular Biology 8, no. 2 (1988): 786–93. http://dx.doi.org/10.1128/mcb.8.2.786-793.1988.

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The involvement of the ras oncogenes in tumorigenesis was investigated in keratoacanthomas, which are benign and self-regressing skin tumors, both in humans and in a corresponding animal model system. Keratoacanthomas were induced on rabbit ears by repeated applications of 7,12-dimethylbenz(a)anthracene. About 60% of the tumor DNAs produced transformed foci after transfection into NIH 3T3 cells, and in all of them the transforming gene was identified as H-ras by Southern and Northern (RNA) hybridization. Immunoprecipitation experiments suggested that the transforming rabbit H-ras protein carri

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15

Leon, J., H. Kamino, J. J. Steinberg, and A. Pellicer. "H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system." Molecular and Cellular Biology 8, no. 2 (1988): 786–93. http://dx.doi.org/10.1128/mcb.8.2.786.

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The involvement of the ras oncogenes in tumorigenesis was investigated in keratoacanthomas, which are benign and self-regressing skin tumors, both in humans and in a corresponding animal model system. Keratoacanthomas were induced on rabbit ears by repeated applications of 7,12-dimethylbenz(a)anthracene. About 60% of the tumor DNAs produced transformed foci after transfection into NIH 3T3 cells, and in all of them the transforming gene was identified as H-ras by Southern and Northern (RNA) hybridization. Immunoprecipitation experiments suggested that the transforming rabbit H-ras protein carri

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16

Alexander, J. O'D, and Alan Lyell. "Multiple keratoacanthomas." Journal of the American Academy of Dermatology 12, no. 2 (1985): 376. http://dx.doi.org/10.1016/s0190-9622(85)80069-4.

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17

Taylor, Mitchell, Amelia Pham, Michaela Clausen, and Kamruz Darabi. "Eruptive Keratoacanthoma in a 59-year-old Female with Chronic Kidney Disease: A Case Report and Review of Treatment Approaches." SKIN The Journal of Cutaneous Medicine 7, no. 3 (2023): 764–70. http://dx.doi.org/10.25251/skin.7.3.2.

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We present the case of a 59-year-old female with multiple squamous neoplasms, including keratoacanthomas, well-differentiated squamous cell carcinomas, and prurigo nodules. The patient developed dozens of lesions progressively over the course of a few years. Keratoacanthomas can be challenging to distinguish from well-differentiated squamous cell carcinomas; this and the presence of numerous lesions poses a major challenge with diagnosing and managing this condition. The pathogenesis, challenges with diagnosis and management, and treatment regimens for eruptive keratoacanthomas are further dis

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18

Jensen, P., O. P. Clausen, O. Geiran, et al. "Cutaneous complications in heart transplant recipients in Norway 1983-1993." Acta Dermato-Venereologica 75, no. 5 (1995): 400–403. http://dx.doi.org/10.2340/0001555575400403.

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All Norweigian heart transplant recipients with more than one year's survival (n = 140) were investigated for dermatological disorders. Observation time after transplantation was 1-10 years (mean 5.0 years). Patients alive at the end of 1993 (n = 122) were examined clinically, and medical records for all patients were reviewed. The histopathological diagnoses of excised skin specimens were reevaluated. Malignant skin tumours (i.e. basal cell carcinoma, squamous cell carcinoma and malignant melanoma) and/or premalignant skin tumours (i.e. morbus Bowen (carcinoma in situ), solar keratosis and ke

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19

Vollum, D. J. "(40) Multiple keratoacanthomas." British Journal of Dermatology 95 (July 29, 2006): 78–79. http://dx.doi.org/10.1111/j.1365-2133.1976.tb07928.x.

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20

Paniker, Parwathi “Uma.” "Diagnosing solitary keratoacanthomas." American Journal of Medicine 118, no. 1 (2005): 19. http://dx.doi.org/10.1016/j.amjmed.2004.11.012.

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21

FRANK, TOBY L., HENRY C. MAGUIRE, and STEVEN S. GREENBAUM. "MULTIPLE PAINFUL KERATOACANTHOMAS." International Journal of Dermatology 35, no. 9 (1996): 648–50. http://dx.doi.org/10.1111/j.1365-4362.1996.tb03691.x.

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22

Affleck, Andrew G. "Multiple persistent keratoacanthomas." International Journal of Dermatology 46, no. 10 (2007): 1105. http://dx.doi.org/10.1111/j.1365-4632.2007.03328.x.

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23

Santos, Thamiles, Jener Farias, Sheinaz Hassam, Marcio Oliveira, and Alessandra Valente. "Diagnosis and treatment of keratoacanthoma in the lower lip: A case report." Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 65, no. 3 (2024): 136–41. http://dx.doi.org/10.24873/j.rpemd.2024.10.1225.

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Keratoacanthoma diagnosis is challenging, and therefore, this publication contributes to the current literature by presenting epidemiological data and describing clinical and histopathological characteristics and the treatment decision. A 69-year-old Caucasian male patient presented with a well-delimited exophytic growth nodule in the lower lip measuring 10 millimeters with circular shape, firm consistency, pink color, and rough surface. The clinical suspicion was squamous cell carcinoma. An incisional biopsy and histopathological analysis were performed, which revealed fragments of oral mucos

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24

Fraga, Garth R., and Trisha A. Prossick. "Tattoo-associated keratoacanthomas: a series of 8 patients with 11 keratoacanthomas." Journal of Cutaneous Pathology 37, no. 1 (2010): 85–90. http://dx.doi.org/10.1111/j.1600-0560.2009.01286.x.

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25

Solanes, Ferran, Koen Chiers, Marja J. L. Kik, and Tom Hellebuyck. "Gross, Histologic and Immunohistochemical Characteristics of Keratoacanthomas in Lizards." Animals 13, no. 3 (2023): 398. http://dx.doi.org/10.3390/ani13030398.

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The present study describes the clinical behavior as well as the histopathologic and immunohistochemical characteristics of keratoacanthomas (Kas) in three different saurian species. While Kas presented as two dermal lesions in a bearded dragon (Pogona vitticeps), multicentric Kas were observed in three panther chameleons (Furcifer pardalis) and a veiled chameleon (Chamaeleo calyptratus). Macroscopically, Kas presented as dome-shaped skin tumors with a centralized keratinous pearl and a diameter ranging from 0.1–1.5 cm. In all lizards, Kas were predominantly located at the dorsolateral body wa

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26

Quinn, Adam, Leith Banney, Joanna Perry-Keene, and David Weedon. "Eruptive keratoacanthomas in tattoos." Australasian Journal of Dermatology 58, no. 4 (2017): 317–18. http://dx.doi.org/10.1111/ajd.12558.

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27

Elston, Dirk M. "Medical therapy for keratoacanthomas." Journal of the American Academy of Dermatology 83, no. 5 (2020): 1544–45. http://dx.doi.org/10.1016/j.jaad.2020.06.1011.

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28

Guitart, Joan, and Kenneth Gordon. "Keratoacanthomas and Lymphomatoid Papulosis." American Journal of Dermatopathology 20, no. 4 (1998): 430–32. http://dx.doi.org/10.1097/00000372-199808000-00023.

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29

Höpfl, Reinhard M. "Keratoacanthomas: Human Papillomavirus Associated?" Archives of Dermatology 128, no. 4 (1992): 563. http://dx.doi.org/10.1001/archderm.1992.01680140147025.

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30

Hopfl, R. M. "Keratoacanthomas: human papillomavirus associated?" Archives of Dermatology 128, no. 4 (1992): 563–64. http://dx.doi.org/10.1001/archderm.128.4.563.

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31

Lonsdorf, Anke S., Dominic Edelmann, Thomas Albrecht, et al. "Differential Immunoexpression of Inhibitory Immune Checkpoint Molecules and Clinicopathological Correlates in Keratoacanthoma, Primary Cutaneous Squamous Cell Carcinoma and Metastases." Acta Dermato-Venereologica 104 (February 7, 2024): adv13381. http://dx.doi.org/10.2340/actadv.v104.13381.

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Beyond established anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) and its ligand CD155 are promising novel inhibitory immune checkpoint targets in human malignancies. Yet, in cutaneous squamous cell carcinoma, evidence on the collective expression patterns of these inhibitory immune checkpoints is scarce. Complete tumour sections of 36 cutaneous squamous cell carcinoma, 5 cutaneous metastases and 9 keratoacanthomas, a highly-differentiated, squamoproli

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32

Dinev, Ivan. "Enzootic outbreak and spontaneous regression of keratoacanthomas in a commercial layer flock." Acta Veterinaria Hungarica 61, no. 3 (2013): 366–75. http://dx.doi.org/10.1556/avet.2013.022.

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This paper reports an enzootic outbreak and spontaneous regression of keratoacanthomas among adult layer hens with lesions on the skin of the legs. The observations were performed in a flock of 55,000 commercial layers (50,000 Lohmann White and 5,000 Lohmann Brown). At the age of 30 weeks, Lohmann White layers exhibited a number of growths (at an average of 60 hens per week, representing 0.1% of the flock) in the region of leg toes on a daily basis over 28 weeks that regressed during the remaining flock production period. Gross and histological investigations identified the lesions as keratoac

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33

Lynch, Michael C., and Bryan E. Anderson. "Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome." Dermatology Research and Practice 2010 (2010): 1–3. http://dx.doi.org/10.1155/2010/173160.

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Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS). We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS. Our case highlights the clinical advantages of immunohistochemistry (IHC) in identifying mutations in the mismatch repair (MMR) genes

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34

Oillarburu, Naia, Cécile Pages, Vincent Sibaud, Laurence Lamant, and Marie Terroir. "Rare Immuno-Induced Keratoacanthomas Showed on 18F-FDG PET/CT in a Metastatic Melanoma Patient." Clinical Nuclear Medicine 50, no. 5 (2025): e288-e289. https://doi.org/10.1097/rlu.0000000000005692.

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Abstract A 76-year-old man managed for stage IV advanced melanoma was treated with nivolumab-ipilimumab, complicated by corticotropic insufficiency, hypothyroidism, and rash. At first evaluation, 18F-FDG PET/CT clearly showed complete metabolic response allowing continued treatment with nivolumab alone. At 6 months, 18F-FDG PET/CT fully confirmed the persistence of complete metabolic response but showed the appearance of cutaneous focal uptakes of both lateral thighs and a cutaneous diffuse uptake on lower limbs. Clinically, he had a severe verrucous lichenoid eruption with eruptive keratoacan

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35

Balagula, Yevgeniy, Klaus J. Busam, Richard D. Carvajal, Jedd D. Wolchok, and Patricia L. Myskowski. "Keratoacanthomas associated with imatinib mesylate." Acta Oncologica 50, no. 4 (2010): 593–95. http://dx.doi.org/10.3109/0284186x.2010.537690.

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36

Anzalone, C. Lane, and Philip R. Cohen. "Generalized eruptive keratoacanthomas of Grzybowski." International Journal of Dermatology 53, no. 2 (2013): 131–36. http://dx.doi.org/10.1111/ijd.12318.

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37

Bruscino, N., D. Corradini, P. Campolmi, D. Massi, and G. M. Palleschi. "Superficial radiotherapy for multiple keratoacanthomas." Dermatologic Therapy 27, no. 3 (2013): 163–67. http://dx.doi.org/10.1111/dth.12102.

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38

Joshi, Sarita, Aasa R. Schjølberg, Per Olaf Ekstrøm, et al. "Tp53/p53 status in keratoacanthomas." Journal of Cutaneous Pathology 43, no. 7 (2016): 571–78. http://dx.doi.org/10.1111/cup.12713.

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39

Li, Janet Y., Daniel J. Lewis, and Madeleine Duvic. "Generalised Eruptive Keratoacanthomas of Grzybowski." Journal of Cutaneous Medicine and Surgery 21, no. 5 (2017): 439. http://dx.doi.org/10.1177/1203475417711112.

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40

Ramirez, Mary, Sarah Groff, and Catherine Kowalewski. "Eruptive Keratoacanthomas After Photodynamic Therapy." Dermatologic Surgery 41, no. 12 (2015): 1426–29. http://dx.doi.org/10.1097/dss.0000000000000514.

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41

Kong, Heidi H., Edward W. Cowen, Nilofer S. Azad, William Dahut, Martin Gutierrez, and Maria L. Turner. "Keratoacanthomas associated with sorafenib therapy." Journal of the American Academy of Dermatology 56, no. 1 (2007): 171–72. http://dx.doi.org/10.1016/j.jaad.2006.10.032.

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42

Tidwell, W. James, Janine Malone, and Jeffrey P. Callen. "Eruptive Keratoacanthomas Associated With Leflunomide." JAMA Dermatology 152, no. 1 (2016): 105. http://dx.doi.org/10.1001/jamadermatol.2015.2506.

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43

Courtney, Ashling, and John C. Su. "Generalised eruptive keratoacanthomas of Grzybowski." BMJ Case Reports 17, no. 3 (2024): e260007. http://dx.doi.org/10.1136/bcr-2024-260007.

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44

Kato, N., K. Ito, K. Kimura, and M. Shibata. "Ferguson smith type multiple keratoacanthomas and a keratoacanthoma centrifugum marginatum in a woman from Japan." Journal of the American Academy of Dermatology 49, no. 4 (2003): 741–46. http://dx.doi.org/10.1067/s0190-9622(03)00454-7.

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45

Temelie-Olinici, Doinița, Petronela Bărgăoanu, Iolanda Foia, et al. "Ultrastructural Features of Keratoacanthoma—Clinical Implications." Applied Sciences 12, no. 10 (2022): 5120. http://dx.doi.org/10.3390/app12105120.

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Over the years, keratoacanthomas have been described as some of the most common skin lesions with the potential for malignant transformation, thus constituting an important risk factor for the development of squamous cell carcinoma. The quantification of the risk of malignant transformation is conditioned by the clinical–morphological and etiopathogenic variability of these lesions, with a negative impact on diagnostic and therapeutic management. In this sense, the main objective of this research is to characterize from an ultrastructural perspective the specific tumour microenvironment, by us

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46

Chandrakumar, Shivani Felicia, and Jensen Yeung. "Cutaneous Adverse Events during Vemurafenib Therapy." Journal of Cutaneous Medicine and Surgery 18, no. 4 (2014): 223–28. http://dx.doi.org/10.2310/7750.2013.13120.

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Background: Vemurafenib, an oral agent that selectively targets the BRAF V600E mutation, has recently emerged as the mainstay of treatment in patients with BRAF-positive stage IV melanoma. A spectrum of cutaneous adverse events has been associated with vemurafenib, ranging from benign rashes to malignant side effects such as keratoacanthoma and squamous cell carcinoma. Objective: In this article, we review clinical data regarding the frequency and severity of the common dermatologic side effects associated with vemurafenib; case series and noncontrolled studies evaluating the safety of vemuraf

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47

Kuklin, Igor, Nina Malishevskaya, Muza Kokha, et al. "Generalized eruptive keratoacanthomas of Grzybowski in the practice of a dermatologist: A case report." Our Dermatology Online 13, no. 4 (2022): 437–39. http://dx.doi.org/10.7241/ourd.20224.19.

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The article deals with a case of the clinical observation of a rare disease: generalized eruptive keratoacanthomas of Grzybowski. The disease pattern is characterized by the presence of small, generalized, itchy papules on the skin of the face, eyelids, trunk, extremities, genitals, and oral and laryngeal mucosae. The authors present a case of their own clinical observation of multiple eruptive keratoacanthomas of the Grzybowski type in a fifty-year-old patient seeking medical advice from a dermatologist. The duration of the disease was 2.5 years and its occurrence was preceded by repeated vis

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48

Otto, Tracey S., Alexandra Rubin, Attiya Haroon, Gina Ashforth, and Babar K. Rao. "35328 Morbidities associated with solitary keratoacanthomas." Journal of the American Academy of Dermatology 87, no. 3 (2022): AB184. http://dx.doi.org/10.1016/j.jaad.2022.06.766.

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Gleeson, D., S. Cliff, and M. Das. "Eruptive keratoacanthomas associated with dupilumab therapy." British Journal of Dermatology 186, no. 2 (2021): 376–77. http://dx.doi.org/10.1111/bjd.20781.

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Valenzano, Francesco, Angelo Carbone, Clara De Simone, Teresa Sisto, Paolo Amerio, and Guido Massi. "Cutaneous lupus erythematosus mimicking multiple keratoacanthomas." European Journal of Dermatology 19, no. 2 (2009): 186–87. http://dx.doi.org/10.1684/ejd.2008.0608.

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