Relevant bibliographies by topics / Keratograph / Journal articles

To see the other types of publications on this topic, follow the link: Keratograph.

Journal articles on the topic 'Keratograph'

Author: Grafiati

Published: 9 October 2021

Last updated: 18 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Keratograph.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

Chen, Minjie, Anji Wei, Jianjiang Xu, Xingtao Zhou, and Jiaxu Hong. "Application of Keratograph and Fourier-Domain Optical Coherence Tomography in Measurements of Tear Meniscus Height." Journal of Clinical Medicine 11, no. 5 (2022): 1343. http://dx.doi.org/10.3390/jcm11051343.

Full text

Abstract:

To compare the interoperator repeatability of tear meniscus height (TMH) measurements obtained with a keratograph and Fourier-domain optical coherence tomography (FD-OCT) and to assess the agreement between the methods.Forty-seven eyes with DED and 41 healthy eyes were analyzed using the Schirmer test I and tear breakup time test (TBUT). The TMH was measured three times with each device. The repeatability of measurements was assessed by within-subject standard deviation (Sw), repeatability (2.77 Sw), coefficient of variation (CoV) and intraclass correlation coefficient (ICC). Efficacy in detecting DED was evaluated in terms of the area under the curve (AUC). The TMHs obtained with the keratograph were 0.03 mm lower than those obtained with FD-OCT in both groups (p < 0.001 for the DED group and p = 0.0143 for the control group, respectively). The intraexaminerICCs of the keratographic TMH were 0.789 and 0.817 for the DED and control groups, respectively, and those of the FD-OCT TMH were 0.859 and 0.845, respectively. Although a close correlation was found between the TMHs measured with the keratograph and FD-OCT by the Spearman analysis in both groups (both p < 0.001), poor agreement between the devices was shown in both groups using a Bland–Altman plot. The AUCs of the keratography and FD-OCT results were 0.971 (p < 0.001) and 0.923 (p < 0.001), respectively. Both devices had excellent diagnostic accuracy in differentiating normal patients from DED patients. FD-OCT TMH measurements were more reliable than the keratograph data in the DED group. Agreement between the devices was poor in both groups.

APA, Harvard, Vancouver, ISO, and other styles

Park, Seo Woo, Ha-Rim So, Ji Won Baek, et al. "A Comparison between Keratograph 5M® and IDRA® in Dry Eye Patients." Journal of the Korean Ophthalmological Society 66, no. 4 (2025): 175–80. https://doi.org/10.3341/jkos.2025.66.4.175.

Full text

Abstract:

Purpose: To evaluate the compatibility and usability of test results obtained from the IDRA and Keratograph 5M in clinical settings by comparing their performance in patients with dry eye disease.Methods: From December 27 to 30, 2022, a study was conducted on 30 patients diagnosed with dry eye utilizing both the Keratograph 5M and IDRA devices. The parameters compared and analyzed included lipid layer thickness, tear meniscus height, tear film break-up time, and meibography. A paired t-test was used for statistical comparison. The lipid layer thickness in the Keratograph 5M was graded on a scale from 0 to 4 based on thickness.Results: No significant differences were found between the two devices in tear film break-up time, tear meniscus height, and meibography (p = 0.148, 0.072, 0.124, respectively). However, the tear lipid layer thickness measured by IDRA showed a proportional relationship with the grade assigned by the Keratograph 5M (Kendall R = 0.217, p = 0.037; Spearman R = 0.260, p = 0.045).Conclusions: The IDRA device offers the advantage of performing multiple dry eye tests; simultaneously, thereby saving time compared to the Keratograph 5M. Both devices can be used compatibly with IDRA particularly advantageous for providing a numerical value for tear lipid layer thickness which enhances the convenience of dry eye diagnosis and treatment.

APA, Harvard, Vancouver, ISO, and other styles

García-Marqués, José Vicente, Noelia Martínez-Albert, Cristian Talens-Estarelles, Santiago García-Lázaro, and Alejandro Cerviño. "Repeatability of Non-invasive Keratograph Break-Up Time measurements obtained using Oculus Keratograph 5M." International Ophthalmology 41, no. 7 (2021): 2473–83. http://dx.doi.org/10.1007/s10792-021-01802-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Shin, Haeeun, Soyeon Jung, and Ji Won Jung. "Comparison of Each Eye According to the Order of Noninvasive Keratographic Tear Film Evaluation." Korean Journal of Ophthalmology 37, no. 3 (2023): 230–35. http://dx.doi.org/10.3341/kjo.2022.0135.

Full text

Abstract:

Purpose: To investigate the effect of order of examination on the results of noninvasive keratograph tear film evaluation using Keratograph5M in dry eye patients.Methods: One hundred and four patients with dry eye symptoms were analyzed retrospectively. All patients underwent bilateral noninvasive tear film evaluation using measurements of tear meniscus height (TMH) and noninvasive keratograph break-up time (NIKBUT) obtained using Keratograph5M. Measurements were performed sequentially in the order of right TMH, left TMH, right NIKBUT, and left NIKBUT.Results: There was no statistically significant difference in TMH values between the right and left eyes (0.24 ± 0.08 and 0.23 ± 0.08 mm, respectively). Mean NIKBUT-first (time at first tear film break-up) and mean NIKBUT-average (the mean of all tear film break-up time over the entire cornea) were 6.17 ± 3.28 and 10.00 ± 3.97 seconds, respectively, for right, and 7.43 ± 3.86 and 11.57 ± 4.34 seconds, respectively, for left eyes. In addition, mean NIKBUT-first between right and left eyes, and mean NIKBUT-average between them were statistically significant (p = 0.013 and p = 0.007, respectively). Mean NIKBUT and mean TMH differences were not significantly influenced by right or left eyes, age, or sex (all p > 0.050). Spearman correlation analyses of TMH, NIKBUT-first, and NIKBUT-average results showed moderate positive correlations between right and left eyes (r = 0.470, r = 0.322, and r = 0.576, respectively; p < 0.001).Conclusions: TMH evaluation was not affected by test order; however, NIKBUT measurement was affected by test order, because of reflex tearing due to forced eye opening during the examination. Therefore, TMH should be evaluated before NIKBUT, and sufficient time interval and caution should be needed between NIKBUT measurements on both eyes.

APA, Harvard, Vancouver, ISO, and other styles

Best, N., L. Drury, and J. S. Wolffsohn. "Clinical evaluation of the Oculus Keratograph." Contact Lens and Anterior Eye 35, no. 4 (2012): 171–74. http://dx.doi.org/10.1016/j.clae.2012.04.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Arriola, Villalobos P., Vigo JI Fernández, Valle D. Diaz, nieves JE Peraza, Pérez C. Fernández, and del Castillo JM Benítez. "Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography." Br J Ophthalmol 99, no. 8 (2015): 1120–5. https://doi.org/10.1136/bjophthalmol-2014-306453.

Full text

Abstract:

Aims: To compare intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height measurements (LTMH) obtained with the new Keratograph 5M and a Fourier-domain optical-coherence tomography (OCT; Spectralis OCT) and to assess the agreement between the two devices. Methods: This is a observational cross-sectional study. Thirty eyes of 30 normal subjects were randomly imaged twice with both devices in our setting. Two examiners randomly made LTMH measurements using the devices. To assess intraobserver repeatability and interobserver and intersession reproducibility within-subject SD (Sw), test-retest repeatability, coefficient of variation (CoV) and intraclass correlation coefficients (ICCs) were calculated. Agreement between both devices was also determined. Results: Average LMTH for Keratograph was 235.46±57.61 μm, whereas the mean LTMH measured by OCT was 245.84±67.18 μm. Intraobserver repeatability and interobserver and intersession reproducibility were moderate with Keratograph (CoV ≥0.16%, ≥0.19%, ≥0.17% and ICC ≤0.83, ≤0.76, ≤0.83, respectively) and high for the Spectralis OCT (CoV ≤0.13%, ≤0.12%, ≤0.11% and ICC ≥0.9, ≥0.92, ≥0.92, respectively). No statistically significant difference was detected in mean LMTH measurements made with both devices, although correlation was low (CoV 0.25%, ICC 0.55). Conclusions: Spectralis OCT LTMH measurements were more reliable than the new Keratograph data. Agreement between the devices was poor.

APA, Harvard, Vancouver, ISO, and other styles

Shin, Haeeun, Soyeon Jung, and Ji Won Jung. "Effects of Non-invasive Keratograph Break-Up Time on the Repeatability of Keratometry Measurements." Journal of the Korean Ophthalmological Society 64, no. 2 (2023): 99–107. http://dx.doi.org/10.3341/jkos.2023.64.2.99.

Full text

Abstract:

Purpose: To evaluate the effects of the non-invasive keratograph break-up time on the repeatability of keratometric measurements derived using the Keratograph 5M in patients with dry eye syndrome.Methods: Thirty-six patients with dry eye and 30 controls were enrolled. We measured keratometric values twice in all subjects and explored whether the two measurements differed by more than 0.5 diopter (D) (the absolute value). We also evaluated the relationship between the absolute difference and the non-invasive keratograph break-up time (NIKBUT).Results: The intraclass correlation coefficients for astigmatism, flat keratometry (K), steep K, and mean K were all higher than 0.95 in patients, thus lower than in controls. The proportion of eyes with absolute differences over 0.5 D between the two keratometric values differed significantly between the dry eye and control groups in terms of the flat K and Kmax values (p = 0.033, 0.037). The average NIKBUT was negatively correlated with the absolute differences in Kmax and astigmatism (p = 0.030, R2 = 0.134 and p = 0.017, R2 = 0.160).Conclusions: In patients with dry eye syndrome, keratometric measurements are reliably repeatable, but slightly less so than in normal controls. The proportions of eyes exhibiting absolute keratometric differences over 0.5 D (two measurements) differed in the dry eye and control groups. The lower the non-invasive keratograph break-up time, the poorer the repeatability of keratometric measurements in the dry eye group. Therefore, care is required when obtaining keratometric values for such patients.

APA, Harvard, Vancouver, ISO, and other styles

Srinivasan, Sruthi, Kara Menzies, Luigina Sorbara, and Lyndon Jones. "Non-contact meibography using a novel keratograph." Contact Lens and Anterior Eye 35 (December 2012): e31-e32. http://dx.doi.org/10.1016/j.clae.2012.08.099.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Inferrera, Leandro, Emanuela Aragona, Adam Wylęgała, et al. "The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy." Journal of Clinical Medicine 11, no. 6 (2022): 1602. http://dx.doi.org/10.3390/jcm11061602.

Full text

Abstract:

To prove the role of high-tech investigation in monitoring corneal morphological changes in patients with neurotrophic keratopathy (NK) using Keratograph 5M (K5M) and anterior segment OCT (AS-OCT), corneal healing was monitored with Keratograph 5M (Oculus, Wetzlar, Germany) and AS-OCT (DRI, Triton, Topcon, Tokyo, Japan) in 13 patients (8F and 5M), aged from 24 to 93 years (67.8 ± 19) with severe NK, who were treated with Cenegermin 0.002% (20 μg/mL) (Oxervate®, Dompè, Farmaceutici Spa, Milan, Italy). The surface defects were evaluated on Keratograph 5M with ImageJ software and the corneal thickness variations were measured using DRI-Triton OCT software. Instrumental procedures were performed at baseline, and after 4 and 8 weeks of the treatment, respectively. The main outcome measures were reduction of the ulcers’ area and corneal thickness recovery. The mean area of the corneal ulcers was reduced between baseline and 4 weeks examination in all patients, and at 8 weeks all ulcers were completely healed. An increase of the corneal thickness was evidenced between the baseline visit and after the 4- and 8-week follow-up, respectively. Additionally, only in collaborating subjects the In Vivo Confocal Microscopy (IVCM) was performed with HRT Rostock Cornea Module (Heidelberg Eng GmbH) to study the corneal nerves fibres. High-tech diagnostics with K5M, AS-OCT and IVCM proved useful in the assessment of corneal morphology and the healing process in patients with NK and could be extended to assess other corneal pathologies.

APA, Harvard, Vancouver, ISO, and other styles

Mencucci, Rita, Alberto Morelli, Eleonora Favuzza, Angelo Galano, Anna Maria Roszkowska, and Michela Cennamo. "Hypochlorous acid hygiene solution in patients affected by blepharitis: a prospective randomised study." BMJ Open Ophthalmology 8, no. 1 (2023): e001209. http://dx.doi.org/10.1136/bmjophth-2022-001209.

Full text

Abstract:

Background/aimsTo investigate the clinical outcomes and antimicrobial activity of an hypochlorous acid hygiene solution compared with hyaluronic acid wipes for blepharitis treatment in patients with dry eye disease (DED).MethodsThis study involved 48 eyes of 48 patients affected by blepharitis with mild to moderate DED. 24 patients were treated with a hypochlorous acid hygiene solution (HOCL group) and 24 patients were treated with hyaluronic acid wipes (HYAL group) for a period of 4 weeks. The following clinical outcomes were assessed before (V0) and after the treatment period (V1): non-invasive keratograph break up time (NIK-BUT), tear film BUT (TF-BUT) tear meniscus height (TMH), Keratograph meibography, Meibomian Gland Yield Secretion Score (MGYSS), Corneal Staining Score (CSS), Schirmer test I, Keratograph conjunctival redness score and Ocular Surface Disease Index (OSDI). Moreover, microbiological analysis of upper and lower eyelid margins was performed at V0 both before and 5 min after treatment.ResultsAfter 1-month NIK-BUT and TF-BUT significantly increased in HOCL group, while they did not show a statistically significant difference in HYAL group compared with baseline. OSDI, TMH and MGYSS showed a significant difference in both groups, while Schirmer test, meibography, CSS and conjunctival redness score did not significantly change in both groups. Bacterial load showed a significant reduction in both groups, more pronounced in HOCL group compared with HYAL group.ConclusionsHypochlorous acid hygiene solution can be securely employed in blepharitis treatment considering the satisfying clinical outcomes and antimicrobial activity compared with hyaluronic acid wipes.

APA, Harvard, Vancouver, ISO, and other styles

Toyos, Rolando. "Oculus Pentacam and Keratograph Integration in Advanced Refractive Procedures." Highlights of Ophthalmology 40, no. 2ENG (2012): 6–10. http://dx.doi.org/10.5005/hoo-10101-40202.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Wu, Suqian, Jiaxu Hong, Lijia Tian, Xinhan Cui, Xinghuai Sun, and Jianjiang Xu. "Assessment of Bulbar Redness with a Newly Developed Keratograph." Optometry and Vision Science 92, no. 8 (2015): 892–99. http://dx.doi.org/10.1097/opx.0000000000000643.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Serino, Federica, Valeria Dattilo, Michela Cennamo, et al. "Dupilumab-Associated Blepharoconjunctivitis: Clinical and Morphological Aspects." Biomedicines 11, no. 12 (2023): 3104. http://dx.doi.org/10.3390/biomedicines11123104.

Full text

Abstract:

Purpose: To describe the clinical and morphologic changes in the ocular surface microstructure of patients affected with moderate-to-severe Atopic Dermatitis (AD) before and during Dupilumab treatment. Methods: This is a monocentric observational study on thirty-three patients affected with AD before and during Dupilumab treatment. All patients underwent a slit-lamp examination: complete clinical assessment, Break Up Time test (BUT), Schirmer test, and corneal staining grading (Oxford scale) were performed. Meibomian Glands Dysfunction (MGD) evaluation (Meibography), Non-invasive Keratograph Break Up Time test (NIKBUT), Tear Meniscus Height (TMH), and ocular Redness Score (RS) have been investigated using an OCULUS Keratograph. In vivo images of the conjunctiva, cornea, and meibomian glands have been acquired by confocal microscopy. Results: Sixty-six eyes were included in our study: twenty-two eyes of 11 naive patients with indication for treatment but not in therapy yet (Group 1) and forty-four eyes of 22 patients treated with Dupilumab for at least 4 months (subcutaneous administration of 300 mg every 2 weeks) (Group 2). Either patients treated with Dupilumab or naive patients with moderate-to-severe forms of AD had a tear film instability (TBUT and NIKBUT reduced), whereas the quantity of the tear film was overall normal (Schirmer test and TMH), without statistically significant differences between the two groups. When Meibography was performed with the Keratograph, the difference between Group 1 and Group 2 was statistically significant in terms of Meiboscore (p = 0.0043 and p = 0.0242, respectively), as well as the difference in terms of mean RS. These results paired well with the confocal microscopy results in which we found a decrease in the goblet cell population in the conjunctival epithelium in the treated group (5.2 cells/mm), along with inflammatory cells that were more concentrated around the adenoid lumina of the meibomian glands. Conclusions: In recent years, the use of Dupilumab has been increasing, but mild-to-severe conjunctivitis is a common side effect. Our major results demonstrate a loss of meibomian glands at the Keratograph examination: we can assume a reduced meibum secretion and an evaporative dry eye with MGD. We suggest that the inflammation of the ocular surface may involve not only the cornea and the conjunctiva, but also the meibomian glands, and Dupilumab may play a role. However, the frequency of clear conjunctivitis is not as common as reported in the literature.

APA, Harvard, Vancouver, ISO, and other styles

Fan, Ling-Ling, Jian Gao, Lun Liu, and Rong-Feng Liao. "Influence of pars plana vitrectomy on ocular surface using noninvasive Keratograph 5M." International Eye Research 2, no. 4 (2021): 184–89. http://dx.doi.org/10.18240/ier.2021.04.02.

Full text

Abstract:

AIM: To evaluate the influence of pars plana vitrectomy (PPV) on ocular surface using Keratograph 5M. METHODS: Totally 30 consecutive patients (30 eyes) undergoing primary 23-gauge PPV were recruited in the study. Ocular Surface Disease Index (OSDI) questionnaire was performed. Ocular surface parameters, including tear meniscus height (TMH), noninvasive tear break up time (NITBUT) and bulbar redness score were obtained preoperatively, in 1, 2, 4, 8 and 12wk postoperatively by Keratograph 5M. Correlations between all the clinical parameters were analyzed further. RESULTS: The percentages of both photophobia and gritty within 4wk after PPV were significantly higher than pre-operation, while they decreased to the preoperative levels in both 8wk and 12wk postoperatively. The percentage of sore eyes in the first week postoperatively was significantly higher than pre-operation, but there were no significant differences between the percentages of pre-operation and 2, 4, 8, and 12wk postoperatively. OSDI score increased significantly within 4wk postoperatively, but it returned to the preoperative level in 8 and 12wk. TMH increased with 2wk postoperatively, but there were no significant differences compared with preoperation. Both NITBUT-first and NITBUT-average shortened significantly within 8 weeks postoperatively, but they gradually improved to the preoperative levels in 12wk. Bulbar redness score was significantly higher than the preoperative level within 4wk postoperatively, but it returned to the preoperative level in 8wk. NITBUT-first and NITBUT-average had a significant positive correlation at each visit. TMH had a significant positive correlation with NITBUT-average in the first week postoperatively. CONCLUSION: Keratograph 5M can provide a reliable noninvasive method to assess the influence of PPV on the ocular surface. PPV may cause various changes in both symptoms and signs of ocular surface damages at the early stage, while all these changes will return to preoperative levels gradually in 12wk postoperatively.

APA, Harvard, Vancouver, ISO, and other styles

Vaccaro, Sabrina, Massimiliano Borselli, Giovanni Scalia, et al. "A Novel Noninvasive Screening Tool for Dry Eye Disease." Diagnostics 14, no. 12 (2024): 1209. http://dx.doi.org/10.3390/diagnostics14121209.

Full text

Abstract:

Purpose: To assess the feasibility and the diagnostic accuracy of the new tool, DEvice© (AI, Rome, Italy), for screening patients with dry eye disease (DED). Methods: This study was performed at the University Magna Græcia of Catanzaro. Enrolled patients were classified as affected by DED (group 1) or not (group 2) using an already validated tool (Keratograph 5M, Oculus, Germany), evaluating the noninvasive keratograph breakup time (NIKBUT), tear meniscus height (TMH), meibomian gland loss (MGL), and bulbar redness. All the patients were then examined by means of DEvice©, which allowed the measurement of the relative humidity (RH) and temperature of the ocular surface. Symptoms were scored using the Ocular Surface Disease Index (OSDI) questionnaire. Results: Overall, 40 patients (17 males and 23 females, mean age 38.0 ± 17.1 years) were included: of these, 20 belonged to group 1 and the remaining 20 to group 2. Using Keratograph 5M, significant differences between groups 1 and 2 were detected for NIKBUT-first (respectively, 4.97 ± 1.85 vs. 13.95 ± 4.8 s; p < 0.0001) and for NIKBUT-average (10.55 ± 4.39 vs. 15.96 ± 4.08 s; p = 0.0003). No statistically significant changes were detected for TMH (p = 0.565), MGL (p = 0.051), and bulbar redness (p = 0.687). Using Device©, a statistically significant higher value of RH was found in group 1 compared to group 2 (respectively, 85.93 ± 10.63 vs. 73.05 ± 12.84%; p = 0.0049). A statistically significant correlation was found between RH and OSDI (r = 0.406; p = 0.009). The value RH showed a discriminating power to detect DED with an AUC = 0.782 (standard error 0.07264; 95% CI 0.6401–0.9249; p = 0.0022). Conclusions: The DEvice© can effectively discriminate DED patients from healthy subjects. The parameter RH showed good sensitivity, making this tool ideal for a fast and noninvasive DED screening.

APA, Harvard, Vancouver, ISO, and other styles

Yao, Jie, Xin-Quan Liu, Yi Zhu, and Da-Hu Wang. "Measurement of the Lower Lid Margin Thickness by Oculus Keratograph." Eye & Contact Lens: Science & Clinical Practice 47, no. 6 (2021): 341–46. http://dx.doi.org/10.1097/icl.0000000000000782.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Srinivasan, Sruthi, Kara Menzies, Luigina Sorbara, and Lyndon Jones. "Infrared Imaging of Meibomian Gland Structure Using a Novel Keratograph." Optometry and Vision Science 89, no. 5 (2012): 788–94. http://dx.doi.org/10.1097/opx.0b013e318253de93.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Wang, Xiu, Xiaoxiao Lu, Jun Yang, et al. "Evaluation of Dry Eye and Meibomian Gland Dysfunction in Teenagers with Myopia through Noninvasive Keratograph." Journal of Ophthalmology 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6761206.

Full text

Abstract:

Purpose. This study aims to evaluate dry eye and ocular surface conditions of myopic teenagers by using questionnaire and clinical examinations.Methods. A total of 496 eyes from 248 myopic teenagers (7–18 years old) were studied. We administered Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp examination, and Keratograph 5M. The patients were divided into 2 groups based on OSDI dry eye standard, and their ocular surfaces and meibomian gland conditions were evaluated.Results. The tear meniscus heights of the dry eye and normal groups were in normal range. Corneal fluorescein scores were significantly higher whereas noninvasive break-up time was dramatically shorter in the dry eye group than in the normal group. All three meibomian gland dysfunction parameters (i.e., meibomian gland orifice scores, meibomian gland secretion scores, and meibomian gland dropout scores) of the dry eye group were significantly higher than those of the normal group (P<0.0001).Conclusions. The prevalence of dry eye in myopic teenagers is 18.95%. Meibomian gland dysfunction plays an important role in dry eye in myopic teenagers. The Keratograph 5M appears to provide an effective noninvasive method for assessing ocular surface situation of myopic teenagers.

APA, Harvard, Vancouver, ISO, and other styles

Musilová, Lenka, Alena Vodičková, and František Pluháček. "Repeatability of Noninvasive Break-Up Time Measurements using Keratograph Oculus 3." Czech and Slovak Ophthalmology 80, no. 5 (2024): 266–70. https://doi.org/10.31348/2024/26.

Full text

Abstract:

Aim: The primary aim of this study is to evaluate the repeatability of noninvasive break-up time (NIBUT) measurement by keratograph when it is determined from one, two or three partial measurements, and to recommend a suitable methodology for practice. Another goal is to verify that repeated measurements do not affect the measured value. Material and Methods: Thirty-eight healthy volunteers (30 women and 8 men) aged between 19 and 50 years old were included in the study, in which only one eye of each volunteer was measured. The study was designed as a prospective one. Each subject adapted to the local conditions of the laboratory for 15 minutes and subsequently underwent two series of NIBUT measurements (test, retest) on an OCULUS 3 Keratograph. The minimum time interval between the two series was 10 minutes, in which each series contained three partial measurements approximately 3 three measurements in the given series. Repeatability was assessed by a Bland-Altman analysis and expressed as a repeatability coefficient. In every case, only the time of the first break-up of the tear film was monitored. Results: The statistical analysis did not show statistically significant differences both between partial measurements of NIBUT in the individual series (p = 0.92, p = 0.81) and when comparing all six measurements (p = 0.95). The mean values of the partial measurements ranged from 13.6 s to 14.4 s. The repeatability coefficients were found to be 15.0 s, 12.1 s and 10.0 s for methodologies A, B and C, respectively. A supplementary analysis for 12 eyes with low NIBUT (< 10 s) showed statistically significantly better repeatability in this group, with coefficients of 7.0 s (methodology A), 6.0 s (B) and 4.6 s (C). Conclusion: Determination of NIBUT from three consecutive measurements (with a sufficient interval of ideally a few minutes) significantly improves repeatability. Such repeated NIBUT measurements do not have a significant effect on the measured value. The mentioned methodology for measuring NIBUT on a keratograph can be recommended for use in practice.

APA, Harvard, Vancouver, ISO, and other styles

García-Marqués, José Vicente, Cristian Talens-Estarelles, Santiago García-Lázaro, and Alejandro Cerviño. "The Effects of Soft Contact Lens Wear on The Tear Film and Meibomian Gland Drop-Out and Visibility." Life 12, no. 8 (2022): 1177. http://dx.doi.org/10.3390/life12081177.

Full text

Abstract:

As contact lens (CL) wear affects the ocular surface, this cross-sectional study aims to assess the effects of soft CL wear and its duration on the tear film and meibomian gland (MG) drop-out and visibility. Thirty non-CL wearers (22.5 ± 2.3 years) and twenty-four soft CL wearers (23.8 ± 2.2 years) participated in this study. The Keratograph 5M was used to assess the ocular surface. CL users were surveyed on years of CL wear and hours per week. MG visibility was assessed using a previously developed method based on analysing pixel intensity of meibographies. The CL group showed higher gland drop-out (p < 0.001) and lower gland visibility (p < 0.022). Gland drop-out was independently associated with CL wear (p = 0.006). When gland drop-out was excluded, the relative energy of pixel intensity values showed an independent association with CL wear (p = 0.005). Prolonged hours of CL wear were associated with higher dry eye symptoms and entropy of MGs (p < 0.029). A reduction in non-invasive keratograph break-up time was associated with using CLs for ≥8 years (p = 0.030). Overall, gland drop-out was higher and gland visibility lower in soft CL wearers. New gland visibility metrics might help to assess MGs in soft CL wearers quickly and objectively.

APA, Harvard, Vancouver, ISO, and other styles

Tian, Lei, Jing-hao Qu, Xiao-yu zhang, and Xu-guang Sun. "Repeatability and Reproducibility of Noninvasive Keratograph 5M Measurements in Patients with Dry Eye Disease." Journal of Ophthalmology 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/8013621.

Full text

Abstract:

Purpose. To determine the intraexaminer repeatability and interexaminer reproducibility of tear meniscus height (TMH) and noninvasive Keratograph tear breakup time (NIKBUT) measurements obtained with the Keratograph 5M (K5M) in a sample of healthy and dry eye populations.Methods. Forty-two patients with dry eye disease (DED group) and 42 healthy subjects (healthy group) were recruited in this prospective study. In all subjects, each eye received 3 consecutive measurements using the K5M for the TMH and NIKBUTs (NIKBUT-first and NIKBUT-average). And then a different examiner repeated the measurements. The repeatability and reproducibility of measurements were assessed by the coefficient of variation (CV) and intraclass correlation coefficient (ICC).Results. The repeatability and reproducibility of TMH and NIKBUTs were good in both DED and healthy groups (CV% ≤ 26.1% and ICC ≥ 0.75 for all measurements). Patients with DED showed better intraexaminer repeatability for NIKBUTs, but worse for TMH than healthy subjects. Average TMH, NIKBUT-first, and NIKBUT-average were significantly lower in DED group than in healthy group (allPvalues < 0.05).Conclusions. Measurements of TMH and NIKBUTs obtained with the K5M may provide a simple, noninvasive screening test for dry eye with acceptable repeatability and reproducibility. The NIKBUTs were more reliable, but TMH was less reliable in patients with DED.

APA, Harvard, Vancouver, ISO, and other styles

García-Montero, María, Laura Rico-del-Viejo, Amalia Lorente-Velázquez, Irene Martínez-Alberquilla, Jose Luis Hernández-Verdejo, and David Madrid-Costa. "Repeatability of Noninvasive Keratograph 5M Measurements Associated With Contact Lens Wear." Eye & Contact Lens: Science & Clinical Practice 45, no. 6 (2019): 377–81. http://dx.doi.org/10.1097/icl.0000000000000596.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Zhong, Sue, Hezheng Zhou, Xiao Chen, Wenqiang Zhang, and Liqun Yi. "Influence of glaucoma surgery on the ocular surface using oculus keratograph." International Ophthalmology 39, no. 4 (2018): 745–52. http://dx.doi.org/10.1007/s10792-018-0869-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Giannaccare, Giuseppe, Sabrina Vaccaro, Massimiliano Borselli, et al. "A Novel Ophthalmic Solution Containing Glicopro® Complex for the Treatment of Patients with Dry Eye Disease: Results from a Pilot Study." Journal of Clinical Medicine 13, no. 5 (2024): 1447. http://dx.doi.org/10.3390/jcm13051447.

Full text

Abstract:

(1) Background: Dry eye disease (DED) is a multifactorial ocular surface disease characterized by an imbalance in ocular surface homeostasis, and tear substitutes constitute the first line of treatment. The present study aimed to evaluate the changes in the signs and symptoms of patients with DED treated with a novel tear substitute containing the GlicoPro® complex. (2) Methods: Patients with DED not successfully responding to other tear substitutes were enrolled and treated with a novel ophthalmic solution (two drops four times daily). Patients were examined before starting the study treatment (T0) and after 30 (T1) and 60 (T2) days of treatment by means of Keratograph for the evaluation of the following: (i) tear meniscus height (TMH); (ii) noninvasive Keratograph break-up time (NIKBUT); (iii) bulbar redness; and (iv) infrared meibography. The SANDE questionnaire was administered to assess ocular discomfort symptoms. Analysis of the tear content of proenkephalin and Met/Leu-enkephalin was also performed. (3) Results: At T2, a significant improvement in NIKBUT first, average, and class, TMH, and SANDE score was found. The tear content of proenkephalins was significantly higher at T1, whereas processed active Met/Leu-enkephalins increased at both T1 and T2. (4) Conclusions: Our novel tear substitute based on GlicoPro® resulted in a significant improvement in ocular discomfort symptoms, tear volume, and stability in the patients treated. The increase in active peptides processed in tears may represent the pathophysiological substrate underlying this finding.

APA, Harvard, Vancouver, ISO, and other styles

徐, 桂花. "Clinical Evaluation of Tear Film Lipid Layer in Normal Subjects with Keratograph 5M." Hans Journal of Ophthalmology 09, no. 01 (2020): 7–15. http://dx.doi.org/10.12677/hjo.2020.91002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Hong, Jiaxu, Xinghuai Sun, Anji Wei, et al. "Assessment of Tear Film Stability in Dry Eye With a Newly Developed Keratograph." Cornea 32, no. 5 (2013): 716–21. http://dx.doi.org/10.1097/ico.0b013e3182714425.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Safonova, O. V., and E. M. Titarenko. "An experience of using transdermal intense pulsed light therapy in the treatment of meibomian glands dysfunction in a patient with transplant disease." Reflection, no. 2 (January 11, 2022): 41–44. http://dx.doi.org/10.25276/2686-6986-2021-2-41-44.

Full text

Abstract:

Purpose. To present an experience of using transdermal pulsed light therapy in combination with meibomian glands secret expression in a patient with transplant disease. Clinical case. Patient M., 63 years old, was referred with a diagnosis: condition after penetrating keratoplasty, transplant disease, keratomalacia, dry eye syndrome, meibomian glands dysfunction. In addition to standard ophthalmological examination, a keratographic examination of the anterior surface of the eye using Keratograph 5M device (Oculus) and meibography in infrared light were carried out. Based on the results of the examination, it was decided to enhance conservative therapy with transdermal pulsed light therapy in combination with meibomian glands secret expression. Results. Intense pulsed light therapy using M 22 System (Lumenis, Israel) with meibomian glands secret expression and conservative treatment led to a decrease of patient's subjective complaints (feeling of pain, burning), an improvement in the quality and amount of meibomian glands secret, and decrease of the ocular surface inflammation. The effect of treatment was cumulative and remained stable for at least six weeks after the treatment. Conclusion. The advantages of transdermal pulsed light therapy are pathophysiological approach, elimination of chronic inflammation, long-term effect after treatment (3–6 months) due to cumulative effect and restoration of meibomian glands unction. This clinical case demonstrates the effectiveness of an integrated approach in the treatment of patients with chronic inflammation of the anterior ocular surface and a burdened surgical history, including cases of preparation for repeated reconstructive interventions. Key words: dry eye syndrome, transdermal pulsed light therapy, meibomian glands dysfunction.

APA, Harvard, Vancouver, ISO, and other styles

Wang, An, Zhengyu Gu, Rongfeng Liao, and Zongwen Shuai. "Dry Eye Indexes Estimated by Keratograph 5M of Systemic Lupus Erythematosus Patients without Secondary Sjögren’s Syndrome Correlate with Lupus Activity." Journal of Ophthalmology 2019 (August 29, 2019): 1–8. http://dx.doi.org/10.1155/2019/8509089.

Full text

Abstract:

Purpose. To investigate the incidence, severity, and influencing factors of dry eye in systemic lupus erythematosus (SLE) patients without secondary Sjögren’s syndrome (sSS). Methods. A total of 78 patients who were diagnosed with systemic lupus erythematosus and met inclusion criteria were selected as the study subjects in this cross-sectional study. Tear meniscus height (TMH) and noninvasive Keratograph tear breakup time (NIKBUT) including NIKBUT-first and NIKBUT-average of the subjects were measured using a noninvasive ocular analyzer, the Keratograph 5M (Oculus, Wetzlar, Germany). Symptoms related to dry eye were assessed using the Ocular Surface Disease Index (OSDI). The severity of SLE was evaluated by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). Results of the levels of 4 serum antibodies were collected from the patients’ medical records. Correlations between SLEDAI and various ocular surface parameters were analyzed, and multiple-factor binary logistic regression analysis was conducted. Results. In the study subjects, mean TMH was 0.22 mm, mean NIKBUT-first was 9.12 s, and mean OSDI was 13.14. The subjects (19 eyes) whose NIKBUT-average was < 10 s and OSDI was ≥ 13 accounted for 24.36% of all the included patients. SLEDAI showed a statistically significant correlation with TMH (r = −0.233, p=0.040), NIKBUT-first (r = −0.254, p=0.025), NIKBUT-average (r = −0.343, p=0.002), and OSDI (r = 0.256, p=0.024). According to multiple-factor binary logistic regression analysis, SLEDAI could be considered as a risk factor of the incidence of dry eye in SLE patients without sSS. Conclusions. One-fourth of the SLE patients without sSS suffered from dry eye, and the severity of dry eye correlated with the activity of SLE.

APA, Harvard, Vancouver, ISO, and other styles

李, 颖. "Evaluation of Ocular Surface Condition in the Tattoo on Eyelid Margin by Noninvasive Keratograph." Hans Journal of Ophthalmology 06, no. 01 (2017): 7–11. http://dx.doi.org/10.12677/hjo.2017.61002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Pérez Bartolomé, Francisco, Jose María Martínez de la Casa, Pedro Arriola Villalobos, et al. "Ocular Redness Measured with the Keratograph 5M in Patients Using Anti-Glaucoma Eye Drops." Seminars in Ophthalmology 33, no. 5 (2017): 643–50. http://dx.doi.org/10.1080/08820538.2017.1395891.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Tashbayev, Behzod, Reza A. Badian, Xiangjun Chen, et al. "Comparison of non-invasive and fluorescein tear film break-up time in a 65-year-old Norwegian population: a cross-sectional study." BMJ Open 15, no. 4 (2025): e090305. https://doi.org/10.1136/bmjopen-2024-090305.

Full text

Abstract:

ObjectivesMeasurement of tear film stability is central in dry eye disease (DED) diagnosis. In this study, we aimed to compare the performance of two methods of tear film stability measurement: non-invasive tear break-up time (NIBUT) and fluorescein tear film break-up time (FTBUT).DesignCross-sectional study.Setting and participantsThe study involved 132 subjects of 65-year-old inhabitants of the Oslo region who were not seeking ophthalmic care.InterventionsThe participants underwent a battery of DED tests, including NIBUT measured on Oculus Keratograph 5M and a traditional method using fluorescein drops (FTBUT). Oculus Keratograph 5M measures two types of NIBUT:; appearance time of the first dry spot (NIBUTFirst) and average NIBUTAvg.Results74 participants (56%) were female and 58 were male (44%). Subjects presented with varying degrees of DED signs and symptoms. Mean values of NIBUTFirstand FTBUT from all the participants were significantly different (6.2±4.9 s vs 8.6±6.2 s, p<0.0001). There was also a significant difference between NIBUTFirstand NIBUTAvgvalues (6.2±4.9 s vs 8.3±5.5 s, p<0.0001). In contrast, no difference was observed between FTBUT and NIBUTAvgvalues (8.6±6.2 s vs 8.3±5.5 s, p=0.655). The receiver operating characteristic curve analysis was performed to compare NIBUT and FTBUT in regards to other clinical tests (Ocular Surface Disease Index, ocular surface staining, blink interval, eye redness, corneal sensitivity, lid debris, Schirmer I test, tear osmolarity, meibum quality, meibum expressibility, lid hyperemia, tear meniscus height,. irregular lid margin, conjunctival hyperaemia, margin telangiectasia, lipid layer and meibomian gland drop-out). While FTBUT demonstrated results with area under the curve>0.6, neither NIBUTFirstnor NIBUTAvgshowed significant results.ConclusionNIBUTFirstwas shorter than FTBUT. Low correlation between NIBUT and FTBUT indicates that these diagnostic tests are not interchangeable. Other DED tests had correlation, though low, while NIBUT did not demonstrate correlation.

APA, Harvard, Vancouver, ISO, and other styles

Fahmy, RaniaM, and Amal Aldarwesh. "Correlation between dry eye and refractive error in Saudi young adults using noninvasive Keratograph 4." Indian Journal of Ophthalmology 66, no. 5 (2018): 653. http://dx.doi.org/10.4103/ijo.ijo_1103_17.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Jeong, Seongyong, and Sang Bumm Lee. "Reliability of a New Non-invasive Tear Film Break-up Time Measurement Using a Keratograph." Journal of the Korean Ophthalmological Society 57, no. 9 (2016): 1354. http://dx.doi.org/10.3341/jkos.2016.57.9.1354.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Xie, Wenjia, Xia Zhang, Yesheng Xu, and Yu-Feng Yao. "Assessment of Tear Film and Bulbar Redness by Keratograph 5M in Pediatric Patients After Orthokeratology." Eye & Contact Lens: Science & Clinical Practice 44 (November 2018): S382—S386. http://dx.doi.org/10.1097/icl.0000000000000501.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Pérez-Bartolomé, F., C. Sanz-Pozo, J. M. Martínez-de la Casa, P. Arriola-Villalobos, C. Fernández-Pérez, and J. García-Feijoó. "Assessment of ocular redness measurements obtained with keratograph 5M and correlation with subjective grading scales." Journal Français d'Ophtalmologie 41, no. 9 (2018): 836–46. http://dx.doi.org/10.1016/j.jfo.2018.03.007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Marx, Sebastian, Stanislav Baluschev, and Wolfgang Sickenberger. "Einfluss phospholipidhaltiger Augentropfen auf das Abtrocknungsverhalten weicher Kontaktlinsen." Optometry & Contact Lenses 2, no. 5 (2022): 171–77. http://dx.doi.org/10.54352/dozv.ilca8295.

Full text

Abstract:

Purpose. The primary objective of the study was to determine differences between in vitro surface de-wetting of soft con- tact lens (SCL) materials out of saline solution, before and after treatment with phospholipid containing rewetting drops. Material and Methods. Fifteen lenses of different SCL mate- rial classes according to ISO 18369 were tested (polymacon, nelfilcon A, ocufilcon D, balafilcon A, somofilcon A, lotrafilcon B). The lenses were rinsed and stored in saline solution to min- imize the effect of the original blister solution. A de-wetting video was captured for every lens using the Keratograph 5M. Afterwards all lenses were soaked in phospholipid containing rewetting solution for 25 hours. The lenses were gently ag- itated by an orbital shaker with a frequency 0.25 Hz, tilting up to 15°. After treatment, all lenses were equilibrated again in saline solution for at least 30 minutes. De-wetting videos were captured again. In vitro “Non-Invasive Keratograph Dry Up Time“ (NIK-DUT) was assessed for a measurement time of 180 s. The results were expressed by the Area Under Curve (AUC) as well as clinical relevant time point to reach 4.82 mm2 de-wetting. Results. The AUC results before and after treatment with phospholipid containing rewetting solution were: polymacon 4870.9 ± 942.7 and 6214.1 ± 932.1, nelfilcon A 4688.0 ± 1065.1 and 6959.8 ± 1081.8, ocufilcon D 3612.6 ± 875.5 and 7042.0 ± 714.3, balafilcon A 4170.4 ± 927.2 and 7385.6 ± 879.8, somofil- con A 4284.50 ± 833.8 and 6762.2 ± 1380.2 and lotrafilcon B, comfilcon A 4973.3 ± 1249.3 and 7415.7 ± 994.8. All differences were statistically significant at a significance level of 0.05 with P<0.001 (Wilcoxon rank sum test). The mean time to reach 4.82 mm2 de-wetting was 19 s. Conclusion. The used phospholipid containing solution did interact with all soft contact lens materials and lead to accelerated in vitro de-wetting. As the de-wetting area of 4.82 mm2 is reached after a typical interblink period for con- tact lens wearers during attentional visual tasks, it is unlikely to expect a drop of the visual acuity by one log line. Keywords Contact Lenses, Dry Eye

APA, Harvard, Vancouver, ISO, and other styles

Arriola-Villalobos, Pedro, José Ignacio Fernández-Vigo, David Díaz-Valle, Jorge E. Peraza-Nieves, Cristina Fernández-Pérez, and José M. Benítez-del-Castillo. "Assessment of lower tear meniscus measurements obtained with Keratograph and agreement with Fourier-domain optical-coherence tomography." British Journal of Ophthalmology 99, no. 8 (2015): 1120–25. http://dx.doi.org/10.1136/bjophthalmol-2014-306453.

Full text

APA, Harvard, Vancouver, ISO, and other styles

De Luca, Andrea, Alessandro Ferraro, Chiara De Gregorio, et al. "Promising High-Tech Devices in Dry Eye Disease Diagnosis." Life 13, no. 7 (2023): 1425. http://dx.doi.org/10.3390/life13071425.

Full text

Abstract:

Background: Dry eye disease (DED) is a common and debilitating condition that affects millions of people worldwide. Despite its prevalence, the diagnosis and management of DED can be challenging, as the condition is multifactorial and symptoms can be nonspecific. In recent years, there have been significant advancements in diagnostic technology for DED, including the development of several new devices. Methods: A literature review of articles on the dry eye syndrome and innovative diagnostic devices was carried out to provide an overview of some of the current high-tech diagnostic tools for DED, specifically focusing on the TearLab Osmolarity System, DEvice Hygrometer, IDRA, Tearcheck, Keratograph 5M, Cornea Dome Lens Imaging System, I-PEN Osmolarity System, LipiView II interferometer, LacryDiag Ocular Surface Analyzer, Tearscope-Plus, and Cobra HD Camera. Conclusions: Despite the fact that consistent use of these tools in clinical settings could facilitate diagnosis, no diagnostic device can replace the TFOS algorithm.

APA, Harvard, Vancouver, ISO, and other styles

Fu, Pin-I., Po-Chiung Fang, Ren-Wen Ho, et al. "Determination of Tear Lipid Film Thickness Based on a Reflected Placido Disk Tear Film Analyzer." Diagnostics 10, no. 6 (2020): 353. http://dx.doi.org/10.3390/diagnostics10060353.

Full text

Abstract:

This study aims at determining the thickness of the tear lipid layer (LL) observed from a placido-disc-based tear film analyzer. We prospectively collected reflections of placido-disk LL images using a tear film analyzer (Keratograph® 5M, Oculus) from subjects with dry eye symptoms. The LL thickness (LLT) over the inferior half of the cornea was estimated with the use of interference color analysis and the preprocessing of images with and without ring segmentation were obtained and analyzed. Moreover, LLTs before and after 1 h of applying topical ointment (Duratears, Alcon) were compared to validate the estimation of LLT. Our results suggested that the tear LLT can be assessed using a placido-disk-based tear film analyzer and interference color analysis. We verified a high correlation between non-segmented and segmented LL images and estimated LLT increase after applying ointment. In addition, we concluded that LLT can be evaluated by direct interference analysis without segmentation preprocessing.

APA, Harvard, Vancouver, ISO, and other styles

Schwarz, Tim, and Eric Rein. "Anpassung von Sklerallinsen bei Unverträglichkeit von Korneallinsen nach Keratoplastik." Optometry & Contact Lenses 4, no. 8 (2024): 288–93. http://dx.doi.org/10.54352/dozv.jpuv8771.

Full text

Abstract:

Purpose. The aim of this case report is to describe the treatment of a 47-year-old man with scleral lenses due to intolerance of corneal contact lenses after keratoplasty as a result of keratoconus. Material and Methods. The initial examinations included visual acuity tests, slit lamp examination and detailed corneal topography using Keratograph 5M and Pentacam AXL Wave. Based on these measurements, scleral lenses were fitted to improve visual acuity and wearing comfort of the contact lenses. Results. The fitted scleral lenses were subjectively and objectively tolerated without complications the whole day. The visual acuity improved from 0.05 to 1.0 in the right eye and from 0.80p to 1.00 in the left eye. Conclusion. The fitting of scleral lenses offers many advantages over corneal lenses in cases of corneal ectasia or dry eyes. In this case, scleral lenses provided significantly improved visual results and comfort. Regular follow-up examinations were scheduled to ensure safe and complication-free vision with the contact lenses.

APA, Harvard, Vancouver, ISO, and other styles

Zheng, Qinxiang, Lei Wang, Han Wen, et al. "Impact of Incomplete Blinking Analyzed Using a Deep Learning Model With the Keratograph 5M in Dry Eye Disease." Translational Vision Science & Technology 11, no. 3 (2022): 38. http://dx.doi.org/10.1167/tvst.11.3.38.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Alfaro-Juárez, Asunción, Manuel Caro-Magdaleno, Jesús Montero-Iruzubieta, et al. "Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency." Clinical Ophthalmology Volume 13 (October 2019): 2025–33. http://dx.doi.org/10.2147/opth.s218313.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Li, Ning, Tao Wang, Ruixue Wang, and Xuanchu Duan. "Tear Film Instability and Meibomian Gland Dysfunction Correlate with the Pterygium Size and Thickness Pre- and Postexcision in Patients with Pterygium." Journal of Ophthalmology 2019 (December 3, 2019): 1–9. http://dx.doi.org/10.1155/2019/5935239.

Full text

Abstract:

Purpose. This study aimed to evaluate the effects of excision on dry eye and meibomian gland dysfunction (MGD) in individuals with pterygium, before and after surgery. It also aimed to investigate how these effects correlate with the size and thickness of the pterygium. Subjects and Methods. 63 eyes from 63 patients with primary nasal pterygium and 45 eyes from 45 healthy volunteers without ocular pathologies were enrolled in this study. 63 eyes from 63 patients underwent pterygium surgery. ImageJ software was used to calculate the pterygium size based on images of the anterior segments. Anterior segment spectral domain optical coherence tomography (SD-OCT) was performed preoperatively to measure the thickness of the pterygium 1 mm anterior to the nasal scleral spur. The ocular surface disease index (OSDI), Schirmer I Test (SIT), and MGD grade were used to evaluate the eyes, and the eyes were imaged using the noninvasive keratograph average tear film breakup time (NIBUTav), tear meniscus height (TMH), meiboscore, and lipid layer grading tools of the Oculus® Keratograph 5M, preoperatively and at 1, 3, and 6 months postoperatively. Results. The OSDI, NIBUTav, lid margin abnormality, meiboscore, and lipid layer grading values differed significantly in the pterygium patients in comparison with the controls (p<0.01 for all scores). However, the SIT and TMH values were unchanged between the two groups (all p>0.05). Multivariate regression analysis demonstrated that the NIBUTav, meiboscore, and lipid layer grading score was significantly correlated with the pterygium parameters, such as size and thickness. The postoperative OSDI, NIBUTav, lid margin abnormality, and lipid layer grading values improved significantly (p<0.05 for all scores). The SIT, TMH, and meiboscore results did not differ significantly between the pre- and postoperative values (p>0.05). Among the conventional and automated indexes, at 1 month postoperatively, SIT and TMH were significantly correlated with the pterygium parameters, but no correlation was observed at 3 and 6 months postoperatively. The OSDI, NIBUTav, meiboscore, and lipid layer grading values at 1, 3, and 6 months postoperatively were significantly correlated with the pterygium parameters. Conclusion. Abnormal tear film and meibomian gland (MG) function improved following pterygium excision in the patients with primary pterygium, which was associated with uncomfortable ocular symptoms. Pterygium parameters, such as size and thickness, correlated with the dry eye and MGD indexes in patients pre- and postoperatively, potentially offering a novel strategy for clinical implementation of pterygium excision surgery.

APA, Harvard, Vancouver, ISO, and other styles

Ehsaei, Asieh, Nasrin Moghadas Sharif, Negareh Yazdani, Leila Shahkarami, and Hadi Ostadi Moghaddam. "Analysis of age, gender, and refractive error-related changes of the anterior corneal surface parameters using oculus keratograph topography." Journal of Current Ophthalmology 32, no. 3 (2020): 263. http://dx.doi.org/10.4103/joco.joco_7_20.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Baek, Jiwon, Sang Hee Doh, and Sung Kun Chung. "Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye." Cornea 34, no. 10 (2015): 1209–13. http://dx.doi.org/10.1097/ico.0000000000000575.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Marx, Sebastian, and Wolfgang Sickenberger. "A novel in-vitro method for assessing contact lens surface dewetting: Non-invasive keratograph dry-up time (NIK-DUT)." Contact Lens and Anterior Eye 40, no. 6 (2017): 382–88. http://dx.doi.org/10.1016/j.clae.2017.05.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Hafezi, Nikki L., and Farhad Hafezi. "Developing Affordable, Portable and Simplistic Diagnostic Sensors to Improve Access to Care." Sensors 22, no. 3 (2022): 1181. http://dx.doi.org/10.3390/s22031181.

Full text

Abstract:

Ophthalmology is a highly technical specialty, especially in the area of diagnostic equipment. While the field is innovative, the access to cutting-edge technology is limited with reference to the global population. A significant way to improve overall healthcare is to understand the needs and possibilities of all possible consumers when developing sophisticated and accurate medical devices. The Smartphone-based Keratograph (SBK), is an example of a new project that uses real world feedback, addresses an unmet medical need, and implements commercially available components to create a device that is affordable, portable and simplistic to operate. The long-term goal of the SBK is to collect data from users for supervised machine-learning. This machine-learning aspect will ultimately aid in the development of an artificial intelligence device to enable even earlier detection of keratoconus, especially in children and adolescents. Again, the ultimate goal of any medical device should be to improve patient care, and to make a significant improvement on vision healthcare for the global population, providing access to this technology is essential.

APA, Harvard, Vancouver, ISO, and other styles

Yeo, Sharon, Ryan Lee, Han Tun Aung, and Louis Tong. "Agreement of non-invasive tear break up time measurement between Tomey RT-7000 Auto Refractor-Keratometer and Oculus Keratograph 5M." Clinical Ophthalmology Volume 10 (September 2016): 1785–90. http://dx.doi.org/10.2147/opth.s110180.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Sandhu, Japmehr Kaur, Swati Singh, and Sayan Basu. "Case Series: Severe meibomian gland loss in polycystic ovarian syndrome patients on estrogen-progesterone therapy: A case series." F1000Research 12 (July 11, 2024): 1154. http://dx.doi.org/10.12688/f1000research.139229.2.

Full text

Abstract:

Purpose: To report the ocular surface and meibomian gland changes in polycystic ovarian syndrome (PCOS) women taking hormone supplementation. Methods: Case series. Results: Three women (27 ± 11 years) already diagnosed with PCOS presented with dry eye symptoms (mean OSDI, 37.5) for a mean duration of 13 months and were taking hormonal supplements for a mean duration of 60 ± 11 months. The hormonal supplements included oral estrogen (n=3), oral progesterone (n=3), antiandrogen cyproterone (n=1) and isotretinoin (n=1). Ocular surface evaluation revealed mean NIBUT of 9.9 ± 1.6 seconds and mean TMH of 0.27 ± 0.05 mm, assessed non-invasively using Oculus keratograph 5M (K5M). Meibography (K5M) showed near total loss of all meibomian glands (n=8/12 eyelids) with residual ghost glands in all four eyelids of two patients, and gland shortening alone in one patient. The gland morphology did not change following intense thermal pulsation treatment or cessation of hormonal therapy. Conclusions: Near-total irreversible meibomian gland loss was seen in two young PCOS women taking hormonal supplements. Collaboration between ophthalmologists and gynecologists is advisable for early detection and better understanding of dry eye disease (DED) progression in these patients.

APA, Harvard, Vancouver, ISO, and other styles

Sandhu, Japmehr Kaur, Swati Singh, and Sayan Basu. "Case Series: Severe meibomian gland loss in polycystic ovarian syndrome patients on estrogen-progesterone therapy." F1000Research 12 (September 14, 2023): 1154. http://dx.doi.org/10.12688/f1000research.139229.1.

Full text

Abstract:

Purpose: To report the ocular surface and meibomian gland changes in polycystic ovarian syndrome (PCOS) women taking hormone supplementation. Methods: Case series. Results: Three women (27 ± 11 years) already diagnosed with PCOS presented with dry eye symptoms (mean OSDI, 37.5) for a mean duration of 13 months and were taking hormonal supplements for a mean duration of 60 ± 11 months. The hormonal supplements included oral estrogen (n=3), oral progesterone (n=3), antiandrogen cyproterone (n=1) and isotretinoin (n=1). Ocular surface evaluation revealed mean NIBUT of 9.9 ± 1.6 seconds and mean TMH of 0.27 ± 0.05 mm assessed non-invasively using Oculus keratograph 5M (K5M). Meibography (K5M) showed near total loss of all meibomian glands (n=8/12 eyelids) with residual ghost glands in all four eyelids of two patients, and gland shortening alone in one eyelid. The gland morphology did not change following intense thermal pulsation treatment or cessation of hormonal therapy. Conclusions: Near-total irreversible meibomian gland loss was seen in two young PCOS women taking hormonal supplements. Collaboration between ophthalmologists and gynecologists is advisable for early detection and better understanding of dry eye disease (DED) progression in these patients.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!