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Journal articles on the topic 'Keywords: Schiff base'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Ismayilov, R. H., and P. A. Fatullayeva. "Metal complexes with dihydrazone of malonic acid dihydrazine." Scientific Petroleum, no. 1 (June 30, 2021): 58–62. http://dx.doi.org/10.53404/sci.petro.20210100008.

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This research includes synthesis and characterization of transition metal complexes of Cu (II), Co (II) and Ni (II) with hydrazone Schiff base ligand. Schiff base lagand was synthesized by reaction of malonic ester dihydrazide and 5-bromo salicylaldehyde. The structure of obtained complexes was studied by IR and electron spectroscopy. Keywords: hydrazone Schiff base ligand; copper complex; nickel complex; cobalt complex; IR and UV-Vis spectroscopy.

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2

Singh, Anil K., Camille Sandorfy, and Janos H. Fendler. "Dodecylammonium-glutamate Schiff bases of retinal." Canadian Journal of Chemistry 68, no. 7 (1990): 1258–62. http://dx.doi.org/10.1139/v90-194.

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Dodecylammonium glutamate (4) has been prepared from dodecylamine (2) and l-glutamic acid (3) in ethanol and in aqueous ethanol. The obtained crystalline glutamic acid salt of dodecylamine (4) has been characterized by absorption, FTIR, 1H NMR, 13C NMR, and mass spectroscopy. Reaction of all-trans retinal (5) with the α-amino group of 4 gave a Schiff base (6), which was protonated by the α-COOH group of the glutamyl residue. However, the protonated Schiff base underwent acid-catalyzed hydrolysis to 2 + 3 + 5. Some of 5 reacted with 2 to give the corresponding Schiff base. The proposed structur

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3

Daljeet, Singh Manhas*1 Anuja Chauhan. "SYNTHESIS AND NMR STUDY OF HYDROXYQUINOXALINE CARBOXALIDINE AMINO METHYL PHENOL COBALT (II) METAL COMPLEX." iajps,csk publications 03, no. 11 (2016): 1350–53. https://doi.org/10.5281/zenodo.195198.

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<em>Transition metal complex of Schiff base formed by the condensation of quinoxaline-2-carboxaldehyde with 2-aminophenol or were synthesized and characterized by NMR spectroscopy. The phenolic OH and NH signals which are found at 12.85 and 11.52 ppm in the spectrum of the ligand are not seen in the spectrum of the Co (II) complex indicating the enolisation of the Schiff base in Co (II) complex and participation of the phenolic OH group in chelation with proton displacement</em> <strong>Keywords</strong>: <em>condensation, carboxaldehyde, 2-aminophenol, Schiff base, NMR spectra</em>

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4

TRIPATHEE, NEHA. "Exploring the Versatility: Applications of Schiff Base Complexes in Catalysis, Medicine, and Material Science." WORLD JOURNAL OF APPLIED SCIENCE AND RESEARCH 10-11, no. 01-02 (2021): 33. https://doi.org/10.59467/wjasr.2021.10-11.33.

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Schiff bases, characterized by the imine (?RC=N?) functional group, are condensation products of carbonyl compounds and primary amines, with wide-ranging applications in medicinal chemistry, catalysis, and material science. Their complexes exhibit diverse biological activities such as antimicrobial, anticancer, antioxidant, anti-inflammatory, and antiplasmodium properties. These bioactivities are enhanced by the metal ion coordination within the Schiff base framework, showing potential for drug development against resistant pathogens and cancers. Catalytically, Schiff base complexes, particula

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5

TRIPATHEE, NEHA. "Exploring the Versatility: Applications of Schiff Base Complexes in Catalysis, Medicine, and Material Science." WORLD JOURNAL OF APPLIED SCIENCE AND RESEARCH 10-11, no. 01-02 (2021): 33. https://doi.org/10.59467/wjasr.2020-21.10-11.33.

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Schiff bases, characterized by the imine (?RC=N?) functional group, are condensation products of carbonyl compounds and primary amines, with wide-ranging applications in medicinal chemistry, catalysis, and material science. Their complexes exhibit diverse biological activities such as antimicrobial, anticancer, antioxidant, anti-inflammatory, and antiplasmodium properties. These bioactivities are enhanced by the metal ion coordination within the Schiff base framework, showing potential for drug development against resistant pathogens and cancers. Catalytically, Schiff base complexes, particula

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6

Kamatam, Prasuna M., Vanitha Sanambatla, and Seshaiah Kalluru. "Biological studies of Schiff base, 2-(1-hydroxycyclohexyl) phenyl methylene hydrazine carbothioamide and its Cu(II) and Zn(II) metal complexes." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4666–71. http://dx.doi.org/10.55522/jmpas.v11i2.2621.

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Condensation of 1-hydroxycyclohexyl phenyl ketone with hydrazine carbothioamide produced a new Schiff base, 2-(1-hydroxycyclohexyl) phenyl methylene hydrazine carbothioamide. The Cu(II) and Zn(II) metal complexes of the Schiff base were prepared. The different spectroscopic methods such as FT-IR, UV-Visible, 1H NMR, and 13C NMR spectroscopy were used to elucidate the structural characteristics of the synthesized compounds. Further, the biological applications of the prepared Schiff bases and its metal complexes were studied for the antibacterial activity. The antimicrobial investigation was ca

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7

Le-Thanh, Hoa, and D. Vocelle. "1H NMR studies of proton transfer in Schiff base and carboxylic acid systems." Canadian Journal of Chemistry 68, no. 10 (1990): 1909–16. http://dx.doi.org/10.1139/v90-295.

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When the unconjugated Schiff base, isobutylidene isopropylamine (2), reacts with acids such as the mineral acids HCl, HBr, and HI, or the carboxylic acids trichloroacetic, monochloroacetic, and propionic acid, in CDCl3, several complexes are formed. In this study, 1H NMR allows us to differentiate between several possibilities. With the mineral acids, only 1:1 structures are seen and the chemical shift of the [Formula: see text] proton varies according to the strength of the hydrogen bond between the protonated Schiff base and its counterion. With the carboxylic acids, 1:1 and 1:2 structures a

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8

Varma, Madhuri, Suhas Janwadkar, Himani More, and Mrunmayi Churi. "A review on applications of Schiff bases and their comparison in different field." International Journal of Advance and Applied Research 6, no. 25(A) (2025): 31–34. https://doi.org/10.5281/zenodo.15296298.

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<strong>Abstract: </strong> Schiff bases are adaptable organic compounds that are commonly synthesized through the condensation of various amino compounds with aldehydes or ketones, forming imines. These Schiff base ligands are regarded as privileged ligands due to their straightforward synthesis via condensation. They exhibit a wide range of applications in fields such as medicine, pharmaceuticals, coordination chemistry, biological activities, industries, food packaging, dyes, and polymers, and are also utilized as oxygen detectors. Transition metal complexes, such as those containing copper

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9

Yeole, Sanjay, Vaibhava Sachin More, S. Lokhande R., Suhas Janwadkar, and Dilip Yadav. "Synthesis, Spectral, and Antimicrobial Activity of Some Mixed Ligand Co (II) Complexes of Schiff Base 2-[(3-Hydroxy Phenylimino) Methyl]-4-Nitrophenol with Some Amino Acids." International Journal of Advance and Applied Research 6, no. 25 (2025): 150–55. https://doi.org/10.5281/zenodo.15294469.

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<strong>Abstract:</strong> The mixed ligand complexes of Co (II) with 2-[(3-hydroxy phenylimino)methyl]-4-nitrophenol (HPIMNP) as the primary ligand and amino acids (valine, alanine, or glutamine) as secondary ligands have been synthesised and characterised. The complexes were characterised by elemental analysis, conductivity measurement, 1H NMR, IR, and ultraviolet-visible spectral studies. Schiff base acts as a bidentate ligand, coordinating through deprotonated phenolic oxygen and azomethine <em>N</em>-atom. The conductivity studies of the complexes in DMSO at 10⁻³ M concentration indi

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10

Jaiswal, Amit, Anil Kumar Pal, Dharmendra Kumar Sahu, and Ranjeet Kumar. "Synthesis and characterizations of Hg (II) Complex of Macrocyclic complexes compounds Tetradecahydrodibenzo hexaazacyclooctadecine with HgX2 (X= Cl, Br) by Hirshfeld analysis and antimicrobial activity." Journal of Drug Delivery and Therapeutics 14, no. 3 (2024): 115–21. http://dx.doi.org/10.22270/jddt.v14i3.6476.

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This study examines the synthesis and characterization of a macrocyclic complex molecule having the general formula [M-LX2], where M =Hg (II) with schiff base Tetradecahydrodibenzo hexaazacyclooctadecine ligands. Resulted from the interaction between mercury and the diethyl triamine and benzene- 1, 2 diol in an ethanolic solution. Schiff base and its novel mercury (II) Complexes were studied vibrational in the solid state using spectral, 1H-NMR, IR, UV, and antimicrobial activity approaches. We were able to establish the coordination mode of the metal in complexes by comparing the changes in t

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11

Fatoni, Ahmad, Poedji Loekitowati Hariani, Hermansyah Hermansyah, and Aldes Lesbani. "A Adsorbent of Chitosan Linked by Methylene Bridge and Schiff Base of 4,4-diaminodiphenyl Ether –vanillin : Synthesis, Characterization and Its Application After Reacted by Zn(II) Ion as Antibacterial Agent." Science and Technology Indonesia 3, no. 4 (2018): 173. http://dx.doi.org/10.26554/sti.2018.3.4.173-177.

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The synthesis chitosan linked by methylene bridge-Schiff base of 4,4-diaminodiphenyl ether-vanillin (modified chitosan adsorbent) has been studied. The aims of this research were modification of chitosan with Schiff base of 4,4-diaminodiphenyl ether-vanillin and formaldehyde and its application as antibacterial agent after used as an adsorbent of Zn(II) ion. Characterization of modified chitosan adsorbent was conducted using FTIR spectroscopy. Process of adsorption were conducted at 0.15 g of modified chitosan adsorbent reacted by concentration of Zn(II) ion solution (pH 6, 150 mg/L, 50 mL), c

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12

Karle, Shubham N., and Megha T. Salve. "In Silico Docking and Admet Prediction of a Novel Antibacterial Derivatives (Schiff Base) Targeting Dihydropteroate Synthase (1aj2)." Journal of Pharmaceutical Research 23, no. 2 (2024): 71–76. http://dx.doi.org/10.18579/jopcr/v23.2.37.

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Schiff base-containing (imine or azomethine–C=N–) derivatives have been investigated in relation to a broad range of activity, including antibacterial activity, antiviral activity, anticancer activity, polymer technology and in many other areas due to the presence of moiety in their structures. Antibacterial activity of Schiff bases can achieve by various enzyme inhibitory mechanism. Primary target for the antibacterial drugs is inhibiting dihydropteroate synthase (DHPS) enzyme which result in inhibition of bacterial folate synthesis and act as bactericidal. In this research article Molinspira

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13

Ademidun, Adeola ADESIBIKAN, and Sunday EMMANUEL Stephen. "Synthesis and Characterization of Co (ii) Complex with a Schiff Base Ligand Derived from Salicylaldehyde and 4-chloroaniline." International Journal of Novel Research in Physics Chemistry & Mathematics 10, no. 2 (2023): 12–17. https://doi.org/10.5281/zenodo.8023058.

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<strong>Abstract:</strong> This article presents synthesis of novel Schiff base ligand from N-salicylidene-p-chloroaniline and its Co (II) complex in ratio 1:2 metal-ligands. The complex formed was subjected to elemental analysis and spectroscopic studies (ultraviolet spectroscopy and infra-red spectroscopy) alongside melting point evaluation. From the infrared spectroscopy of the complex, an octahedral arrangement of the ligand around cobalt atom is proposed. The complex formed showed the stability at an ambient condition and it was soluble in most organic solvents. <strong>Keywords:</strong>

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14

Aisha, Ahmad, Mohd Abdulazeez Abduljeleel, Aminu Ahmed, and Sarki Sagagi Balarabe. "SYNTHESIS, CHARACTERIZATIONS AND BOLOGICAL APPLICATIONS OF SCHIFF BASE DERIVED FROM O-PHENYLENEDIAMINE AND 2-HYDROXY-1-NAPTHALDEHYDE AND ITS Mn(II), Co(II), and Zn(II), METAL COMPLEXES." International Journal of Mathematics and Physical Sciences Research 11, no. 1 (2023): 87–93. https://doi.org/10.5281/zenodo.8220570.

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<strong>Abstract:</strong> Schiff base was synthesized by the condensation of o-phenylenediamine and 2-hydroxy-1-napthaldehyde. Its metal complexes were also prepared by reacting the Schiff with metal chlorides in ethanol.. The Schiff base and its metal (II) complexes were characterized by solubility test, melting and decomposition determination, FTIR, magnetic susceptibility, molar conductance analysis. Solubility test was carried on the Schiff base and the complexes which showed that they are all soluble in ethanol DMSO and DMF, but insoluble in water. From the FTIR result, Azomethine v(C=N)

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15

Abid, Samara Hamid, and Haider A. Mahdi. "Synthesis and Anti-Oxidant Properties of Some New Schiff Bases Containing Azole Moieties." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 67. http://dx.doi.org/10.59467/ijhc.2024.34.67.

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Four new Schiff bases (L1-L4) were synthesized and characterized on the basis their spectra of 1H-NMR, 13C-NMR, Fourier transform infrared, and elemental analysis (CHN). The program Gaussian 09 software and DFT-based B3LYP method along using the 6-31G+(d,p) basis set were used for theoretical accounts. The antioxidant activity of the synthesized compounds was evaluated by DPPH scavenger and these compounds showed good antioxidant activity.. KEYWORDS :Antibacterial, Antioxidant, Azomethine, Schiff base.

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16

Mounika, K., A. Pragathi, and C. Gyanakumari. "Synthesis¸ Characterization and Biological Activity of a Schiff Base Derived from 3-Ethoxy Salicylaldehyde and 2-Amino Benzoic acid and its Transition Metal Complexes." Journal of Scientific Research 2, no. 3 (2010): 513. http://dx.doi.org/10.3329/jsr.v2i3.4899.

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A new Schiff base, 3-ethoxy salicylidene amino benzoic acid (ETSAN), has been synthesized from 3-ethoxy salicylaldehyde and 2-amino benzoic acid. Metal complexes of the Schiff base were prepared from nitrate/chloride salts of Ni(II), Co(II) Cu(II) and Zn(II) in an alcoholic medium. The complexes were non-electrolytes in dimethyl sulfoxide solvent (DMSO). The chemical structures of the Schiff-base ligand and its metal complexes were confirmed by various spectroscopic studies like IR, UV-VIS, 1H NMR, 13C NMR, ESI-mass spectra, elemental analysis, molar conductance, thermogravimetric studies and

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17

Laddha, Purushottam R., and Kailash R. Biyani. "Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 44–49. http://dx.doi.org/10.22270/jddt.v9i5-s.3635.

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Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines

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18

Hossain, M. M., M. A. Foysal, M. Mahabub, and Al Amin. "Microwave-assisted Efficient Synthesis of Isatins and spiro-Thiadiazolines under Green Chemistry Protocol." Journal of Scientific Research 2, no. 2 (2010): 322–29. http://dx.doi.org/10.3329/jsr.v2i2.3731.

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MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield. Keywords: Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline;

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19

Mahyavanshi, Jyotindra B., Jayesh M. Pandya, and Girish D. Acharya. "Synthesis of Some New Schiff Base Derivatives of Simazine and Atrazine for In Vitro Antimycobacterial Activity." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 02 (2024): 205. http://dx.doi.org/10.59467/ijhc.2024.34.205.

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This study presents the design and synthesis of some new Schiff base derivatives of simazine and atrazine series for in vitro antitubercular activity. The synthesis of target compounds 5a-h/6a-h was accomplished in two steps starting from simazine (1) and atrazine (2). The first common step involved nucleophilic substitution with 4-aminoacetophenone to give the corresponding 4-substituted derivatives 3/4. The obtained intermediates were subsequently converted to Schiff basses by reacting with various amines. The synthesized compounds were evaluated for potential medicinal properties against tu

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20

Gupta, Sofia, Jaya Bansal, Chhagan Lal, Madhu Bala Raigar, Priyanka Jhajharia, and Mrinal Sharma. "Synthesis and molecular docking insights for thiophene-based Schiff base and anti-cancer target." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 451. https://doi.org/10.59467/ijhc.2025.35.451.

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N-((3,4-Dimethylthiophen-2-yl)methylene)-1H-inden-4-amine (SNB) was synthesized by condensation reaction between 3,4-dimethylthiophene-2-carbaldehyde and 1H-inden-4-amine. The pharmacokinetic potential of the synthesized compound SNB was determined using ADMET profiling, revealing its potential as a potent drug. Further, in silico molecular docking studies against the target cancerous protein (pdb id:2xao) showed excellent binding energy of -7.58 KcaL/moL, thus highlighting its potential as anti-cancer drug. Theoretical insights, supported by computational studies, validate the stability and b

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21

Al-Salim, T., J. S. Hadi, E. A. Al-Nasir, and M. A. Hassen. "The Transfer Hydrogenation Reactions Catalyzed by Rhodium Schiff Base Complexes." Journal of Scientific Research 2, no. 3 (2010): 501. http://dx.doi.org/10.3329/jsr.v2i3.4341.

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Three new Schiff base rhodium (III) complexes, derived from three ligands, L1, L2 and L3 have been prepared and characterized by IR, 1HNMR, mass spectra and the elemental analysis. These complexes have shown efficient catalytic activity in the transfer hydrogenation of wide variety ketones to the corresponding alcohols in formic acid/triethylamine solution under mild reaction conditions. Depending on the ketone, the percentage of conversion for RhL1 have been found to be (51-92%) compared to RhL2 which had a yield of (42-92%) while for RhL3 (71-94%), within time range of 0.5-12 hrs. Keywords:

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22

Mokhnache, Kamel, Salim Madani, and Noureddine Charef. "Antituberculosis: Synthesis and theoretical study of New Schiff base ligand; 2,2'-{(5-amino-1,3-phenylene) bis[nitrilo(E)methylylidene]}dibenzene-1,4-diol." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 82–85. http://dx.doi.org/10.22270/jddt.v10i5.4360.

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The ability to breathe and generate adenosine triphosphate is necessary to the persistence, physiology and pathogenesis of Mycobacterium tuberculosis that causes TuB. By doing a theoretical study of a chemical compound, Schiff Base 2,2'-{(5-amino-1,3-phenylene) bis[nitrilo(E)methylylidene]}dibenzene-1,4-diol, where almost all biological activities have been studied theoretically exploiting a computer software PASS (Prediction of Activity Spectra for Substance) for enhancing Computer Aided Drug Designing, as well as studying the class of toxicity in the human body by GUSAR software, which showe

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23

Hasan, Reham H., and Hasan A. Hasan. "Synergism antibacterial activity for novel synthesized Schiff base ligands and semi-thiosemicarbazones with ß-diketones and 4-aminoantipyrine." Bionatura 7, no. 3 (2022): 1–11. http://dx.doi.org/10.21931/rb/2022.07.03.43.

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Schiff base ligands were synthesised in this work, the first is (Z)-2-((Z)-3-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)-1,3-diphenylpropylidene) hydrazine-1-carboxamide, the second is (Z)-2-((1E,5Z,6E)-5-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-dien-3-ylidene)hydrazine-1-carbothioamide. The Schiff base ligands both were synthesised using the same method (the single pot reaction), using EtOH as the reaction medium and GAA as the catalyst in fixed temperature at 70 0C and reflux for 6 hrs. The starting mate

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24

Awad, Hussein, and Shaimaa A. Bahgat. "Synthesis, Identification, Biological Evaluation of Seven-membered Heterocyclic Derivatives from 2,3-di Chloroaniline." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 131. http://dx.doi.org/10.59467/ijhc.2024.34.131.

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This study?s focus was centered on the synthesis of heterocyclic compounds incorporating a seven-membered ring, specifically 1,3-oxazepine. The initial phase of the synthesis involved the preparation of azo compound (1) through the coupling of the diazonium salt of 2,3-dichloroaniline with 4-bromoacetophenone in an alkaline alcoholic medium. This was then succeeded by the reaction of azo compound (1) with 4-nitroaniline and 4-methoxyaniline in absolute ethanol, employing glacial acetic acid as a catalyst, resulting in Schiff base derivatives (2) and (3), respectively. Subsequent to this, Schif

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25

Sanambatla, Vanitha, Sathish Kumar Nara, Balaji Hari, Varada Reddy Ammireddy, and Saritha Nimmakayala. "Antimicrobial and antioxidant studies of Schiff base, 2-(2-hydroxy-2-methyl-1-phenylpropylidene) hydrazine carbothioamide and its mixed ligand cd (II) complexes." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4470–76. http://dx.doi.org/10.55522/jmpas.v11i1.2451.

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New mononuclear mixed ligand Cadmium(II) complexes of the type [Cd(L)(diimine)] (1,2) [where L = 2-(2-hydroxy-2-methyl-1-phenylpropylidene)hydrazinecarbothioamide; diimine = 2,2’-bipyridine (1), 1,10-phenanthroline (2)] have been synthesized and characterized by spectroscopic techniques such as FT-IR, UV-Visible, and1H and 13CNMR Spectroscopy. From the investigations of spectral data, it is evident that the heterocyclic bases (2,2’-bipyridine and 1,10-Phenanthroline) act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms addition to azomethane nitrogen,

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Kumar, Vivek, Abhay Kumar, and Rajesh Kumar. "Lemon Juice Catalysed Green Synthesis of Triazole Based Schiff Base, Its Physico-Chemical & Spectral Characterisation and Determination of its Binding Stoichiometry with Cu2+ ion." International Journal for Research in Applied Science and Engineering Technology 10, no. 2 (2022): 758–62. http://dx.doi.org/10.22214/ijraset.2022.40379.

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Abstract: In the recent years Environmental Pollution has emerged as a major challenge for human society. Since the start of Industrial Revolution in England, the amount of chemical waste and toxic substances are increasing exponentially in the environment. The traditional synthesis of chemical substances is accompanied by use of large amount of energy, harmful solvents and release of toxic substances in environment. The green synthesis aims to minimise the release and use of harmful toxic material in synthesis. In the present paper we have prepared a triazole derivative, 4-[(E)-Benzylideneami

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27

Deshmukh, S. R. "Novel Schiff Base Ligand and their Fe (III), Co (II) and Ni (II) Complexes: Spectroscopic Investigation and Biological Applications." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 06 (2025): 1–9. https://doi.org/10.55041/ijsrem50878.

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Novel Schiff base ligand derived from condensation reaction between 3-Amino-4-Hydroxy Benzoic Acid and 2-hydroxy-5-nitrobenzaldehyde. Fe (III), Co (II) & Ni (II) metal complexes were formed from the synthesized ligand. FT-IR, UV- Visible 1H-NMR & HRMS Characterization studies were carried out for the confirmation of the structure and bonding of the synthesized ligand and its complexes. Complexes were tested for their antibacterial and antifungal activities using gram positive bacterial strains i.e. Staphylococcus aureus and Bacillus subtilis, gram negative bacterial strains i.e. Escher

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28

Richa, Kothari. "Synthesis of Nickel (II) Schiff Base Molecular Adducts: Spectroscopic Characterization & Antioxidant activity." American Journal of PharmTech Research 12, no. 06 (2022): 124–41. https://doi.org/10.5281/zenodo.7479291.

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ABSTRACT Transition metal complexes of Ni (II) with schiff base ligand (HL) derived from condensation of 3-Bromo benzaldehyde and hydrazine monohydrate were successfully synthesized , characterized and isolated .The schiff base ligand and its Ni(II) complexes prepared were characterized by melting  point /decomposition temperature, solubility, conductivity/ Molar conductance, UV- visible, FT-IR, XRD, TGA and elemental analysis results. In the UV-Vis study, a bathochromic shift of approximately 60 nm indicating the formation of coordinated Ni(II) complexes by more than one coordinating sit

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29

M. Alwan, Shakir, and Ameer H. Kadhim. "Synthesis of New Cephalosporins of Expected Improved Activity and Resistance Against -Lactamases." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 24–32. http://dx.doi.org/10.31351/vol23iss2pp24-32.

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The development of new cephalosporins with improved activity against resistant microbes, such as, MRSA (methicillin resistant Staph. aureus), P. aeruginosa, is of high potential. Chemical synthesis of two new series of thiadiazole linked to cysteine (series 1) and cephalosporins containing thiadiazole linked to cysteine through disulfide bond (series 2) were achieved. The chemical structures of the synthesized compounds were confirmed using spectral (FT-IR, 1H-NMR) and elemental microanalysis. The incorporation of privileged chemical moieties, such as, thiadiazole, Schiff base, cysteine and su

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Luo, Hongyan, Shuang Liu, Steven J. Rettig, and Chris Orvig. "Rhenium and technetium complexes from pentadentate (N3O2) and tetradentate (N2O2) Schiff base ligands." Canadian Journal of Chemistry 73, no. 12 (1995): 2272–81. http://dx.doi.org/10.1139/v95-281.

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The rhenium(V) and technetium(V) complexes: [ReO(apa)], [{ReO(epa)}2O], and [TcOCl(epa)] have been prepared from a potentially pentadentate N3O2 ligand, N,N′-3-azapentane-1,5-diylbis(3-(1-iminoethyl)-6-methyl-2H-pyran-2,4(3H)-dione) (H3apa), or a potentially tetradentate N2O2 ligand, N,N′-ethylene-diylbis(3-(1-iminoethyl)-6-methyl-2H-pyran-2,4(3H)-dione) (H2epa). The N2O2 complexes were synthesized in low yields. There was also evidence indicating that H2ppa, N,N′-propylene-diylbis(3-(1-iminoethyl)-6-methyl-2H-pyran-2,4(3H)-dione), hydrolyzed in the course of coordination, forms a rhenium comp

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31

Haruna, Mukhtar, J. A. Ndahi, B. F. Dowell, and F. T. Sadauki. "Synthesis, Physicochemical and Antimicrobial Studies of Schiff base derived from 2, 4-dinitrophenyl hydrazine with Salicyldehyde and its Co (II) and Ni (II) Complexes." IDOSR JOURNAL OF SCIENTIFIC RESEARCH 9, no. 2 (2024): 1–12. http://dx.doi.org/10.59298/idosrjsr/2024/9.2.1211.100.

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A Schiff base ligand derived from salicylaldehyde and 2, 4-dinitrophenylhydrazine was synthesized, along with its Co(II) and Ni(II) complexes (CoL2 and NiL2). These compounds were characterized by melting point/decomposition temperature, solubility, molar conductance, magnetic susceptibility, infrared analysis, and UV-visible spectrophotometry. The metal-ligand ratio in the complexes is 1:2. All complexes exhibited low molar conductance values (5.2-11.0), indicating their non-electrolytic nature. The synthesized ligand and its metal (II) complexes were evaluated for antibacterial activity agai

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Qing, Ning, Lawrence D. Colebrook, John T. Edward, Allan Kon та Francis L. Chubb. "Reactions of α-phenylglycinamide with some carbonyl compounds. Formation of 5,7-diisopropyl-8,8-dimethyl-2-oxo-3-phenylimidazolidino-[1,2-c]-tetrahydro-[1,3]-oxazine, and determination of structure and stereochemistry by nuclear Overhauser effect difference measurements". Canadian Journal of Chemistry 67, № 10 (1989): 1560–64. http://dx.doi.org/10.1139/v89-238.

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α-Phenylglycinamide 5 reacts with ketones to give either the Schiff base 3 or the 4-imidazolidone 4, but reacts with boiling isobutyraldehyde to give the bicyclic compond 6. The structure and stereochemistry of 6 have been established by 1H nuclear Overhauser effect difference measurements, supported by molecular mechanics calculations. Keywords: structure, stereochemistry, nuclear Overhauser effect, molecular mechanics, α-phenylglycinamide reactions.

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Manpreet, Kaur, Kumar Prashant, Singla Anita, VeerannaYempally, and Kaur Harminder. "Magnetic Iron nanoparticles grafted with Schiff base and Schiff-base Sn complexes for application in catalysis." Abstracts of International Conferences & Meetings (AICM) 1, no. 5 (2021): 10. https://doi.org/10.5281/zenodo.5362743.

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<strong>Introduction: </strong>Modified Fe<sub>3</sub>O<sub>4</sub> nanoparticles display selective catalytic activity with less tedious experimental procedures under mild reaction conditions (1). Difficulty in product separation and use of harsh parameters, in the catalytic conversion of anthracene to industrially important 9,10 anthraquinone is becoming significant challenge in the field of catalysis (2). In the present study, novel Fe<sub>3</sub>O<sub>4</sub>@SB@Sn system was explored in order to address the existing crucial challenges in the catalytic oxidation of anthracene. <strong>Metho

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Kavita, Kumari Meena, Kant Serawat Kamal, and K. Gunsaria R. "In Vitro Evaluation of Antifungal Activity of Synthesized Novel Zn(II) Complex with Schiff base Ligand." Indian Journal of Science and Technology 16, no. 42 (2023): 3721–26. https://doi.org/10.17485/IJST/v16i42.369.

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Abstract <strong>Objectives :</strong> The current study is concerned with creating a Zn(II) complex with a novel schiff base ligand and to evaluate the Zn(II) metal complex's in-vitro antifungal efficacy against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicali. <strong>Methods :</strong> N, N’-bis(2-hydroxy-3-methoxybenzaldehyde)-2-phenyl-1,3-propanediamine was synthesized by using 2-hydroxy-3-methoxybenzaldehyde and 2-phenyl-1,3-propanediamine. Metal precursor Zn(OAc)2.2H2O react with the ligand to form Zn(II) metal complex. The structure of the

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35

Ajima, Ukpe, Johnson Ogoda Onah, Mary Tuga Kuje, Umar David Muhammed, Vuyisa Mzozoyana, and Stephen Olalekan Ojerinde. "Synthesis, characterization and cytotoxic activity of 5- aminotetrazole Schiff bases." Journal of Pharmacy & Bioresources 18, no. 1 (2021): 32–39. http://dx.doi.org/10.4314/jpb.v18i1.4.

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The incidence and prevalence of cancer has been on the rise in recent years and this has been linked to environmental factors, adoption of westernized lifestyle and aging populations. This situation is further complicated by the inadequacies of currently used anticancer agents such as toxicity and resistance which has prompted the search for new and more effective drugs. In this study, Schiff bases of 5-aminotetrazole were prepared by condensing 5- aminotetrazole with various aromatic aldehydes. Preliminary confirmation of compound formation was done using thin layer chromatography while FT-IR

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36

Mokhnache, Kamel, Soraya Madoui, Hanane Khither, El-Khamsa Soltani, Noureddine Charef, and Arrar Lekhmici. "Synthesis, Characterization, Hydrolytic Cleavage, and Biological Activity Studies of 2-[(1e)-N-{2-[(2-{(Z)-[1-(2-Hydroxyphenyl)Ethylidene] Amino}Ethyl)Amino]Ethyl}Ethanimidoyl]Phenol." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 25–29. http://dx.doi.org/10.22270/jddt.v9i5-s.3621.

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A Schiff base ligand 2-[(1E)-N-{2-[(2-{(Z)-[1-(2-hydroxyphenyl) ethylidene] amino}ethyl)amino]ethyl} ethanimidoyl]phenol L was hydrolyzed by copper cation which lead to formation of 8,8-dichloro-2H,3H,5H,6H-1,3-diaza-2-cupracyclopenta[1,3-a]1,3-diaza-2-cupracyclopentane hydrate (Complex), characterized by UV, IR, Powder XRD and by elemental analysis. In vitro antioxidant and anticoagulant, activities of L were evaluated. Antioxidant potential of L was assessed by DPPH scavenging, β-carotene bleaching test, hydroxyl radical scavenging method, ABTS radical scavenging test, and by reducing power

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37

Salman Jasim, Husam, Zainab A. Al-kubaisi, and Hanady S. Al-Shmgani. "Cytotoxic potential activity of quercetin derivatives on MCF-7 breast cancer cell line." Bionatura 8, no. 1 (2023): 1–5. http://dx.doi.org/10.21931/rb/2023.08.01.92.

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Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited its use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), and its benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability and apoptosis were assessed to determine the toxic effects of Q1 and Q2. Cytotoxicity valuation showed that both compounds inhibited MCF-7 cell growth, and lactate dehydrogenase (LDH) activity increased in a dose-dependent asp

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Ghafil, Amer, and Shaimaa Adnan. "Synthesis and Characterization of Heterocyclic Derivatives from 5-Aminotetrazole and Investigation of Their Biological Activities." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 107. http://dx.doi.org/10.59467/ijhc.2024.34.107.

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This study included the synthesis of some new heterocyclic compounds starting with 5-aminotetrazole, which reacted with 2-hydroxy-4-methoxybenzaldehyde to get compound 1. Then, 1 was converted to a Schiff base (2) derivative by reacting 1 with 2-aminothiazole. Then, compound 2 was reacted with different compounds, namely alanine, 2-mercaptoacetic acid, 2-aminobenzoic acid, phthalic anhydride, and malic anhydride, leading to the heterocyclic products imidazolidine (3), thiazolidine (4), quinazoline (5), and oxazepane (6) derivatives, respectively. All these compounds are characterized by 13C-NM

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39

Isyaku, S., H. N. Aliyu, E. C. Ozoro, and T. Abubakar. "Synthesis, characterization and antimicrobial studies of Mn(II) complexes of acetylthiophene and acetyl Furan Schiff base derivatives." Bayero Journal of Pure and Applied Sciences 12, no. 1 (2020): 85–92. http://dx.doi.org/10.4314/bajopas.v12i1.15s.

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Manganese (II) complexes of Schiff bases; 2-acetylthiophene 4‑phenylthiosemi-carbazone (AT-PTSC) and 2-furylmethylketone-4-phenylthiosemi-carbazone (AF‑PTSC) derived from condensation of 2-acetylthiophene and 2-furylmethylketone (2-acetylfuran) each with 4-phenylthiosemicarbazide in (1:1 molar ratio) ethanol, have been synthesized. The Schiff bases and the Mn(II) complexes were characterized on the basis of melting point/decomposition temperature, solubility, magnetic susceptibility, infrared spectra, molar conductance measurements, elemental and gravimetric analyses. The Mn(II) complexes show

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40

Isyaku, S., H. N. Aliyu, E. C. Ozoro, and T. Abubakar. "Synthesis, characterization and antimicrobial studies of Mn(II) complexes of acetylthiophene and acetyl furan Schiff base derivatives." Bayero Journal of Pure and Applied Sciences 12, no. 1 (2020): 251–58. http://dx.doi.org/10.4314/bajopas.v12i1.39s.

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Manganese(II) complexes of Schiff bases; 2-acetylthiophene-4‑phenylthiosemi-carbazone (AT-PTSC) and 2-furylmethylketone-4-phenylthiosemi-carbazone (AF‑PTSC) derived from condensation of 2-acetylthiophene and 2-furylmethylketone (2-acetylfuran) each with 4-phenylthiosemicarbazide in (1:1 molar ratio) ethanol, have been synthesized. The Schiff bases and the Mn(II) complexes were characterized on the basis of melting point/decomposition temperature, solubility, magnetic susceptibility, infrared spectra, molar conductance measurements, elemental and gravimetric analyses. The Mn(II) complexes show

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41

Al Hassani, Rehab A. M., Asim A. Balakit, and Hassan Khuder. "Synthesis, characterization, and biological activity of new metal complexes derived from 1,2,4-triazole Schiff base ligand." Sumer 4 8, CSS 4 (2023): 1–12. http://dx.doi.org/10.21931/rb/css/2023.08.04.16.

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The present study involves the synthesis of a new Schiff base ligand (L) and its complexes(C1-C5) with Co (II), Ni (II), Cu (II), Pd (II), and Pt (IV). The ligand was synthesized by the condensation reaction of 4-Amino-5-(3,4,5-trimethoxy phenyl)-4H-1,2,4-triazole-3-thione (1) with 2-hydroxy-1-naphthaldehyde (2). The structures of the new ligand and its complexes were confirmed by FT-IR, UVvisible, 1H NMR, 13C NMR, mass spectrometry, microelement analysis (CHNS), atomic absorption flame (AAF) spectrophotometry, conductivity, and magnetic susceptibility analysis. The antibacterial activity of t

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42

Abdullah, Abdul-Hfeedh A., Rasel A. A. Mukred, Hakim Q. N. Alarique, Yasmin M. S. Jamil, Abdulwareth A. Almoneafy, and Abdu K. Alssagheir. "Synthesis, Structures and Characterization of a Novel Schiff Base Ligand and their Three Homotrinuclear Metal Complexes and study bioactivity them." Albaydha University Journal 2, no. 3 (2021): 129–41. http://dx.doi.org/10.56807/buj.v2i3.106.

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A novel N-isopropylidine hydrazinedithiocarbamate Schiff base [(CH3)2C=Hy-dtc] was used as stabilizer ligand for three homotrinuclear metal complexes prepared by condensation of ammonium hydrazinedithiocarbamate and acetone and to use them into in-situ reactions with metal chloride salts (M) in 3 : 2 molar ratio [M :L] in ethanol solution to yield Schiff base homotrinuclear metal complexes of the general formula is {M3[(CH3)2C=Hy-dtc]2(Cl)2(H2O)2} where M refers to Co(II) (1), Ni(II) (2) and Cu(II) (3). The structures of the metal complexes were characterized using elemental analysis, molar co

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43

Enriquez, Raul G., Juan M. Fernandez-G, Ismael Leon, William F. Reynolds, Ji Ping Yang, and Margaret Yu. "Investigation of the effect of ring size on the product distribution for the Schiff base reaction of 2-acetylcycloalkanones with diamino alkanes." Canadian Journal of Chemistry 73, no. 1 (1995): 16–21. http://dx.doi.org/10.1139/v95-004.

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The Schiff base condensation reaction of 1,2-diaminoethane with a series of 2-acetylcycloalkanones (from cyclopentanone to cyclooctanone) has been investigated and the products characterized by two-dimensional nuclear magnetic resonance. The site of attack of the amino groups, i.e., ring ketone or acetyl ketone, is determined primarily by ring size. 2-Acetylcyclohexanone yields two products in ca. 9:1 ratio, the major product where the two amino groups attack at the ring ketones of two different cyclohexanone molecules, and the minor product where one amino group attacks one ring carbonyl of o

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44

Sahib, Halah A., and Mohammed H. Mohammed. "Synthesis and Preliminary Biological Activity Evaluation of New N- Substituted Phthalimide Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 247–52. http://dx.doi.org/10.31351/vol29iss1pp247-252.

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A A new series of bases of Schiff (H2-H4) derived from phthalic anhydrideweresynthesized. These Schiff bases were prepared by the reaction of different amines (tyrosine methyl ester, phenylalanine methyl ester, and isoniazid) with the phthalimide derived aldehyde with the aid of glacial acetic acid or triethylamine ascatalysts. All the synthesized compounds were characterized by (FT-IR and 1HNMR) analyses and were in vitro evaluated for their antimicrobial activity against six various kinds of microorganisms. All the synthesized compounds had been screened for their antimicrobial activit

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45

Valarmathy, Govindaraj, Ramanathan Subbalakshmi, Rajendran Nithya, Ragu Nandhini, Balachandaran Sabarika, and Elanchleiyan Aarthy. "Synthesis, Spectral Characterisation and Cytotoxic Evaluation of Substituted Sulfonamide Schiff Bases." Indian Journal of Science and Technology 14, no. 34 (2021): 2731–41. https://doi.org/10.17485/IJST/v14i34.888.

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Abstract <strong>Objectives:</strong> To synthesize Schiff bases i.e 4-((2-hydroxybenzylidene)-amino–N-(5-methyl-1,2-oxozol-3- yl)benzene sulphonamide (L1), 4-((2-hydroxy benzylidene)-amino-N-(thiazol-yl)benzene sulphonamide (L2), 4-((2-hydroxybenzylidene)amino-N-(pyridin-2-yl)benzene sulphonamide by theaction of 2-hydroxybenzaldehyde with sulfathiazole/ sulfamethoxazole/ sulfapyridine in ethanolic media. <strong>Methods:</strong> The Schiff bases obtained were characterized by analytical data, IR, UV, 1H- NMR, 13C-NMR, Mass spectrum and monitored for cytotoxic activity ag

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Ali, M. M., M. Jesmin, S. M. A. Salam, J. A. Khanam, M. F. Islam, and M. N. Islam. "Pesticidal Activities of Some Schiff Bases Derived from Benzoin, Salicylaldehyde, Aminophenol and 2,4 Dinitrophenyl Hydrazine." Journal of Scientific Research 1, no. 3 (2009): 641–46. http://dx.doi.org/10.3329/jsr.v1i3.2585.

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The pesticidal activities of three Schiff bases namely PDH [N- (1 phenyl 2 hydroxy 2 phenyl ethylidine) 2¢4¢ dinitrophenyl hydrazine], PHP [N(1-phenyl 2 hydroxy -2 phenyl ethylidine) 2¢ hydroxy phenyl imine] and HHP [N (2-hydroxy benzylidine) 2¢ hydroxy phenyl imine] derived from benzoin, salicylaldehyde, 2 aminophenol and 2,4 dinitrophenyl hydrazine were evaluated against Tribolium castaneum. Probit mortality were studied by surface film treatment method at different doses of the compounds. The results showed that the LD50 values as recorded after 24 hours of treatment were 15.1268, 3.0922 an

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Sharma, Abhishek Shankar, Salahuddin Salahuddin, Kavita Rana, et al. "Synthesis, anticonvulsant potential, and molecular docking studies of Schiff bases bearing 2', 6-dichloro-2,3'-biquinoline." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 119. https://doi.org/10.59467/ijhc.2025.35.119.

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In the present manuscript, a series of new 2',6-dichloro-N'-(substituted-benzylidene)-[2,3'-biquinoline]-4- carbohydrazides (6a-l; Schiff bases) has been synthesized by the reaction of 2',6-dichloro-[2,3']biquinolinyl-4-carboxylic acid hydrazide (5) with substituted benzaldehydes. All compounds have been screened for anticonvulsant potential by using the subcutaneous pentylenetetrazole model. From the entire series the compounds 6a, 6c, and 6e showed protection against convulsions at the dose concentration of 30 mg/kg body weight in correlation with conventional drug (phenytoin). The molecules

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Mahnashi, Mater H., B. H. Prabhanjana, Sudarshan Seetammanavar, et al. "Synthesis and in silico studies of some new Schiff bases as antimicrobial and antitubercular agents." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 141. https://doi.org/10.59467/ijhc.2025.35.141.

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Ten pyridine carbohydrazide Schiff bases (3a-3e) and (5a-5e) were synthesized by refluxing pyridine carbohydrazides 1 and 4 with different ketones in the presence of ethanol and a few drops of glacial acetic acid. The synthesized compounds were biologically screened for antitubercular and antibacterial activity studies. The fit of these compounds within the active sites of the dihydrofolate reductase (DHFR) and enoyl ACP reductase was evaluated using molecular modeling techniques. The findings of the anticipated ADMET investigation showed that the compounds with the given names have drug-like

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49

Kareem, May Joda. "Synthesis, Spectroscopic Study and Biological Activity of new Bidentate Schiff Base (4-(Dimethylamino) Benzylidene)-5-(3,4,5-Trimethoxybenzyl)-5 Pyrimidine-2,4-Diamine) and Transition Metal Mn(II), Ni(II) and Cu(II) Complexes." Pakistan Journal of Medical and Health Sciences 16, no. 5 (2022): 655–59. http://dx.doi.org/10.53350/pjmhs22165655.

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The Schiff bases ligand (L1) was synthesized by condensing (2,4-diamine (Trimethoxybenzyl 3,4,5)-5 pyrimidine) and (4-dimethylamino benzaldehyde). The transition metal complexes of [Mn(L1)2Cl2], [Ni(L1)2Cl2], and [Cu (L1)2Cl2] were then produced. The ligand and its metal complexes Mn(II), Ni(II), and Cu(II) were examined by analyzing the elemental composition, the metal content, the chloride content, and the molar conductance, FT-IR, 1H-NMR, UV-Vis spectra, magnetic susceptibility, mass spectra, and thermal analysis (TGA). The results indicated that the ligand behaves as a bidentate ligand in

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50

Singh, Anil K., Camille Sandorfy, and Janos H. Fendler. "Retinylidene Schiff bases in surfactant-solubilized water pools in heptane." Canadian Journal of Chemistry 68, no. 9 (1990): 1514–22. http://dx.doi.org/10.1139/v90-233.

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All-trans-retinal (1) was reacted with n-butylamine in sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelles in heptane to form all-trans-N-retinylidene–n-butylamine Schiff bases (2). The extent of protonation of 2 by 3-chloropropionic acid (CPA) to give 3 in AOT reverse micelles in heptane was found to depend on the ratio of [CPA] to [2], as well as on [H2O]/[AOT] (i.e., on the ω value). At any given [2] and ω values, increasing amounts of CPA increased the protonation and at any given constant [2] and [CPA], increasing ω values also increased the protonation. Over a period of 24 hour

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