Relevant bibliographies by topics / Kidney diseases in old age

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Kidney diseases in old age'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Kidney diseases in old age"

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Coyle, JM, BK Bhowmick, and RJ Meara. "Measuring renal function in old age." Reviews in Clinical Gerontology 9, no. 3 (August 1999): 215–19. http://dx.doi.org/10.1017/s0959259899009338.

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The accurate measurement of renal function in elderly subjects is often required, due to structural and functional changes resulting from age and diseases affecting the kidney. Structurally, with age there is progressive loss of renal mass, particularly in the cortex, leading to a decreased number of glomeruli and an increase in the proportion of sclerotic glomeruli. A decline in the glomerular filtration rate (GFR) has been observed in both cross-sectional and longitudinal studies. However, it has also been noted that about one third of subjects have stable renal function, implying that this decline is not universal, and may reflect the effects of age-associated diseases.
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Kaplunova, O. A. "Age features of arterial human kidney vessels." Medical Herald of the South of Russia 10, no. 4 (December 26, 2019): 51–58. http://dx.doi.org/10.21886/2219-8075-2019-10-4-51-58.

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Objective: to study the structural transformations of the architectonics of intra-organ renal arterial vessels in the age aspect.Materials and methods: 150 kidneys of people of diff erent age who died from the reasons which are not connected with diseases of cardiovascular and urinary systems are investigated. The studies were carried out using a set of methods: angiographic, macromicroscopic and morphometry.Results: with increasing age, a decrease in the number of vascular glomeruli in the kidney, the proportion of glomerular mass in the cortical substance of the kidney was found. In old age and in centenarians, a rare capillary network in the cortical substance of the kidney, tortuosity, narrowing and expansion of direct arterioles and capillaries in the cerebral substance was revealed. In old age and in centenarians, compared with adolescence, the relative content of arterial vessels in the cortical substance decreases by 6 times, in the juxtamedullary zone — by 4 and in the cortical substance — by 2 times.Conclusions: the large diameters of the juxtamedullary glomeruli and a large index of the relative content of arterial vessels in the juxtamedullary zone create prerequisites for possible juxtamedullary shunting with urgent adaptation in the norm. The decrease in these indicators in old age, the elderly and centenarians, obviously, explains the age-related decline in the adaptive capacity of the arterial bed of the kidneys. With increasing age, the range of adaptive capabilities of the renal vascular bed of aging people decreases compared to those of mature age.
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Balázs, Endre, Andrea Ruszwurm, Miklós Székely, István Wittmann, and Judit Nagy. "Old age and kidneys." Orvosi Hetilap 149, no. 17 (April 2008): 789–94. http://dx.doi.org/10.1556/oh.2008.28362.

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Age-related changes in renal morphology and function cannot be regarded physiological. The number of glomeruli falls, sclerotic glomeruli and aglomerular arterioles develop. Besides tubular atrophy interstitial fibrosis is often seen, and the age-related vascular changes strongly affect the kidneys. Renal blood flow and GFR decrease, without concomitant changes in se-creatinine. Disorders of tubular transport manifest mainly in salt- and water-excretion and lead to hyposthenuria. The pathogenesis of these age-related changes is not fully understood. Nevertheless, such changes impair the excretory functions and the pharmacokinetics of drugs. In real chronic renal failure other functions (erythropoietin production, vitamin-D, Ca and P metabolism) are also impaired. Due to more frequent occurrence of systemic diseases (diabetes, hypertension, etc.) in the elderly, real chronic renal failure is also more common, and various forms of acute renal failure develop more easily.
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Курмаев, Д. П., С. В. Булгакова, Н. О. Захарова, Е. В. Тренева, and А. В. Николаева. "RELATIONSHIP OF KIDNEY FUNCTIONS WITH GERIATRIC SYNDROMES IN ELDERLY AND OLD WOMEN." Успехи геронтологии, no. 3 (August 2, 2021): 367–74. http://dx.doi.org/10.34922/ae.2021.34.3.005.

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На фоне старения происходит увеличение числа заболеваний, ассоциированных с возрастом, гериатрических синдромов, способствующих развитию нарушений физической и функциональной активности, усиливается риск инвалидизации и смертности. Одним из широко распространенных заболеваний является ХБП, которая опасна не только сама по себе, но и как фактор прогрессирования других возраст-ассоциированных заболеваний и гериатрических синдромов, в том числе старческой астении и саркопении. У пациентов старших возрастных групп ХБП чаще встречается у женщин, чем у мужчин. Ряд исследователей изучают проблемы полиморбидности, развитие и прогрессирование гериатрических синдромов у пациентов с ХБП додиализной и диализной стадий. Несомненна отрицательная роль тяжелых поздних стадий ХБП в развитии старческой астении и саркопении, в то же время связь этих гериатрических синдромов с ранними додиализными стадиями ХБП изучена недостаточно. Поэтому представляет несомненный научный интерес выявление корреляции признаков саркопении и старческой астении у женщин пожилого и старческого возраста в зависимости от функции почек, стадии ХБП. Against the background of aging, there is an increase in the number of diseases associated with age, geriatric syndromes that contribute to the development of disorders of physical and functional activity, the risk of disability and mortality increases. One of the widespread diseases is chronic kidney disease (CKD), which is dangerous not only in itself, but also as a factor in the progression of other age-associated diseases and geriatric syndromes, including frailty and sarcopenia. Among patients of older age groups, CKD is more common in women than in men. A number of researchers are studying the problems of polymorbidity, the development and progression of geriatric syndromes in patients with CKD in the pre-dialysis and dialysis stages. Undoubtedly, the negative role of severe late stages of CKD in the development of senile asthenia and sarcopenia, at the same time, the relationship of these geriatric syndromes with early pre-dialysis stages of CKD has been insufficiently studied. Therefore, it is of undoubted scientific interest to identify correlations between signs of sarcopenia and frailty in elderly and senile women, depending on renal function, stage of CKD.
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Zakharova, N. O., S. V. Bulgakova, E. V. Treneva, and V. M. Guseva. "SPECIFICITY OF ANEMIC SYNDROME IN GERIATRIC PATIENTS WITH CHRONIC KIDNEY DISEASE." Russian Clinical Laboratory Diagnostics 65, no. 5 (April 15, 2020): 275–80. http://dx.doi.org/10.18821/0869-2084-2020-65-5-275-280.

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Anemic syndrome is detected in 10-25% of geriatric patients, and with increasing age, there is a tendency to increase the incidence of the disease. Among the diseases that lead to the development of anemia, kidney pathology plays an important role. Progressive deterioration of kidney function in old age is associated with an increased risk of fractures, sarcopenia, and the development of cognitive impairment. Also, nephrogenic anemia aggravates the prognosis in patients with cardiovascular diseases, which is associated with an increase in myocardial ischemia, an increase in tissue hypoxia, a progression of left ventricular hypertrophy, and a decrease in left ventricular systolic function.
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Baaj, Teim, Mircea Botoca, Octavian Marius Cretu, Ahmed Abu-Awwad, Elena Ardeleanu, Ioan Musta, Ioan Tilea, et al. "Biochemical, Clinical and Prevalence Characteristics of Chronic Kidney Disease Secondary to Arterial Hypertension." Revista de Chimie 71, no. 5 (May 29, 2020): 462–72. http://dx.doi.org/10.37358/rc.20.5.8158.

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Hypertension has been recognized as an important cause of chronic kidney disease (CKD). As the most important part of the hypertensive patients are managed in primary care, implementation of routine early detection of CKD by determination of albuminuria and the estimated glomerular filtration rate (eGFR) at this level is essential for diagnosis and prevention. The present study demonstrated that prevalence of chronic kidney disease in hypertensive patients was 13.32%, being higher in female than men, with old age and in the presence of diabetes mellitus and associated cardiovascular diseases. The reduction of the eGFR depended significant statistically on age, gender and presence of diabetes mellitus, while albuminuria depended on the presence of diabetes and old age. Early detection of CKD in hypertensive patients permits optimal treatment of cardiovascular risk factors, especially concerning the reduction of high blood pressure, therapy with renin-angiotensin system blockers in order to reduce albuminuria and the progression of eGFR decline and treatment of hyperlipidaemia.
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Shu, Chin-Chung, Meng-Kun Tsai, Shu-Wen Lin, Jann-Yuan Wang, Chong-Jen Yu, and Chih-Yuan Lee. "Latent Tuberculosis Infection Increases in Kidney Transplantation Recipients Compared With Transplantation Candidates: A Neglected Perspective in Tuberculosis Control." Clinical Infectious Diseases 71, no. 4 (July 4, 2020): 914–23. http://dx.doi.org/10.1093/cid/ciz851.

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Abstract Background The prevalence and incidence of latent tuberculosis infection (LTBI) in patients with kidney transplantation remain unclear. Methods In this prospective study, we enrolled kidney transplantation candidates (KTCs) and recipients (KTRs) from 2014 to 2018. We defined LTBI as a positive result of QuantiFERON-TB Gold In-tube (QFT). We analyzed the predictors for LTBI acquisition and followed up on QFT assay test for 2 years among those initially without LTBI. Results Of 425 patients enrolled, 305 (71.8%) patients belonged to the KTC group and 120 (28.2%) to the KTR group. The initial QFT showed positive results in 32 (10.5%) and 24 (20.0%) patients in the KTC and KTR groups, respectively (P = .009). The QFT response value in patients with LTBI was higher in the KTR group than in the KTC group (1.85 vs 1.06 IU/mL, P = .046). Multivariate logistic regression showed that old age, absence of bacillus Calmette–Guérin (BCG) scar, presence of donor-specific antibody, and KTR group were independent factors for positive LTBI. For participants with initial negative QFT, positive QFT conversion within a 2-year follow-up was higher after kidney transplantation (20%) than in KTCs (5.5%) (P = .034). Conclusions This study is the first cohort to follow up LTBI status in patients with kidney transplantation and shows its higher prevalence and incidence in KTRs. It indicates that surveillance of LTBI after renal transplantation is important. In addition to status of kidney transplantation, old age, no BCG vaccination, and positive donor-specific antibody are also positive predictors for LTBI.
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Wu, Tianfu, Bindiya Marakkath, Yujin Ye, Elhaum Khobahy, Mei Yan, Jack Hutcheson, Jiankun Zhu, Xinjin Zhou, and Chandra Mohan. "Curcumin Attenuates Both Acute and Chronic Immune Nephritis." International Journal of Molecular Sciences 21, no. 5 (March 4, 2020): 1745. http://dx.doi.org/10.3390/ijms21051745.

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Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the therapeutic effects of curcumin on immune-mediated renal disease in an anti-glomerular basement membrane (GBM) model (representing acute kidney Injury, AKI) and murine lupus model (representing chronic kidney disease, CKD). In the AKI model, female anti-GBM 129/svj mice were administered with curcumin right before disease induction. In the CKD model, female MRL.lpr mice at the age of 8-10 weeks old were treated with curcumin or placebo via oral gavage daily for two months. After treatment, serum autoantibody levels, splenomegaly and spleen cellularity were reduced in murine lupus. Collectively, curcumin ameliorated kidney disease in the two mouse models with either acute or chronic nephritis, as marked by reduced proteinuria, blood urea nitrogen, glomerulonephritis, crescent formation, tubule-interstitial disease, and renal infiltration by lymphocytes. In addition, curcumin treatment reduced activation of the NFkB, MAPK, AKT and pBAD pathways either systemically, or within the inflamed kidneys. These findings suggest that natural food supplements could become an alternative approach to ameliorating immune-mediated kidney diseases.
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Linz, Rachel, Natalie L. Barnes, Adriana M. Zimnicka, Jack H. Kaplan, Betty Eipper, and Svetlana Lutsenko. "Intracellular targeting of copper-transporting ATPase ATP7A in a normal andAtp7b−/−kidney." American Journal of Physiology-Renal Physiology 294, no. 1 (January 2008): F53—F61. http://dx.doi.org/10.1152/ajprenal.00314.2007.

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Kidneys regulate their copper content more effectively than many other organs in diseases of copper deficiency or excess. We demonstrate that two copper-transporting ATPases, ATP7A and ATP7B, contribute to this regulation. ATP7A is expressed, to a variable degree, throughout the kidney and shows age-dependent intracellular localization. In 2-wk-old mice, ATP7A is located in the vicinity of the basolateral membrane, whereas in 20-wk-old mice, ATP7A is predominantly in intracellular vesicles. Acute elevation of serum copper, via intraperitoneal injection, results in the in vivo redistribution of ATP7A from intracellular compartments toward the basolateral membrane, illustrating a role for ATP7A in renal response to changes in copper load. Renal copper homeostasis also requires functional ATP7B, which is coexpressed with ATP7A in renal cells of proximal and distal origin. The kidneys of Atp7b−/−mice, an animal model of Wilson disease, show metabolic alterations manifested by the appearance of highly fluorescent deposits; however, in marked contrast to the liver, renal copper is not significantly elevated. The lack of notable copper accumulation in the Atp7b−/−kidney is likely due to the compensatory export of copper by ATP7A. This interpretation is supported by the predominant localization of ATP7A at the basolateral membrane of Atp7b−/−cortical tubules. Our results suggest that both Cu-ATPases regulate renal copper, with ATP7A playing a major role in exporting copper via basolateral membranes and protecting renal tissue against copper overload.
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Uchmanowicz, Izabella, Anna Chudiak, Beata Jankowska-Polańska, and Robbert Gobbens. "Hypertension and Frailty Syndrome in Old Age: Current Perspectives." Cardiac Failure Review 3, no. 2 (2017): 102. http://dx.doi.org/10.15420/cfr.2017:9:2.

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Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease. Considering the physiological changes resulting from ageing alongside multiple comorbidities, treatment of hypertension in elderly patients poses a significant challenge to treatment teams. Progressive disability with regard to the activities of daily life, more frequent hospitalisations and low quality of life are often seen in elderly patients. There is discussion in the literature regarding frailty syndrome associated with old age. Frailty is understood to involve decreased resistance to stressors, depleted adaptive and physiological reserves of a number of organs, endocrine dysregulation and immune dysfunction. The primary dilemma concerning frailty is whether it should only be defined on the basis of physical factors, or whether psychological and social factors should also be included. Proper nutrition and motor rehabilitation should be prioritised in care for frail patients. The risk of orthostatic hypotension is a significant issue in elderly patients. It results from an autonomic nervous system dysfunction and involves maladjustment of the cardiovascular system to sudden changes in the position of the body. Other significant issues in elderly patients include polypharmacy, increased risk of falls and cognitive impairment. Chronic diseases, including hypertension, deteriorate baroreceptor function and result in irreversible changes in cerebral and coronary circulation. Concurrent frailty or other components of geriatric syndrome in elderly patients are associated with a worse perception of health, an increased number of comorbidities and social isolation of the patient. It may also interfere with treatment adherence. Identifying causes of non-adherence to pharmaceutical treatment is a key factor in planning therapeutic interventions aimed at increasing control, preventing complications, and improving long-term outcomes and any adverse effects of treatment. Diagnosis of frailty and awareness of the associated difficulties in adhering to treatment may allow targeting of those elderly patients who have a poorer prognosis or may be at risk of complications from untreated or undertreated hypertension, and for the planning of interventions to improve hypertension control.
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Dissertations / Theses on the topic "Kidney diseases in old age"

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陸凱縈 and Hoi-ying Victoria Luk. "How does population aging affect disease control among old age from a public health perspective." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42997495.

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Pearson, Melanie A. "Cardiovascular adaptability influences cortical neuronal activation in very old adults /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3137735.

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Luke, Baw D. "Educational attainment and cardiovascular disease related mortality a retrospective cohort evaluation of Chinese elderly population in Hong Kong /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41711373.

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陸坡 and Baw D. Luke. "Educational attainment and cardiovascular disease related mortality: a retrospective cohort evaluation ofChinese elderly population in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41711373.

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Compte, Nathalie. "Impact of clinical factors on inflammaging and Toll-like receptors responses in old age." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209155.

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Le vieillissement s’accompagne d’une altération globale des fonctions physiologiques notamment celles de l’immunité :on parle « d’immunosénescence ». Ce processus se traduit entre autre par l’installation d’un état inflammatoire chronique caractérisé par une augmentation des taux sériques de cytokines telles que l’interleukine(IL)-6 et des protéines de la phase aigüe. Cet état proinflammatoire serait incriminé dans le déclin des fonctions physiologiques, la fragilité et les syndromes gériatriques. Par ailleurs, les maladies cardiovasculaires, la dépression et l’infection chronique par le Cytomégalovirus (CMV) sont également associés à un état inflammatoire chronique. La prévalence de ces comorbidités étant importante chez les patients gériatriques, ces maladies pourraient donc contribuer à l’association observée entre marqueurs de l’inflammation et les syndromes gériatriques.

Les infections représentent un problème majeur en gériatrie. Les cellules du système immunitaire inné jouent un rôle important dans les défenses contre les agents pathogènes. La reconnaissance de ceux-ci par les cellules dendritiques, les macrophages ou les monocytes fait intervenir une série de molécules telles que les récepteurs de la famille Toll (TLR). Certains travaux suggèrent que la fonction des cellules de l’immunité innée pourrait être perturbée chez les individus âgés mais ces données restent controversées.

Dans ce travail, nous souhaitons aborder les hypothèses suivantes :

•\
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished

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Yu, Li, and 于力. "The association between floor level of residence and mortality of elders living in public housing estates in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46944047.

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Tan, Boon-Kiang. "Non-invasive determinants of osteoporotic fracture risk." University of Western Australia. Centre for Musculoskeletal Studies, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0125.

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[Truncated abstract] The cost of managing osteoporotic fractures places a significant financial burden on the health-care system. To reduce the fracture burden, early identification of fracture risk is essential to allow early intervention. The limitations associated with dual-energy X-ray absorptiometry (DXA), such as limited sensitivity and specificity, cost, ionising radiation and accessibility, have resulted in the emergence of other technologies for assessing bone fragility. An example is the portable and non-ionising quantitative ultrasound (QUS) technology. The discriminatory power of quantitative ultrasonometry in fracture risk identification, either independently or in combination with other established risk factors, currently remains contentious. It is recommended that fracture risk assessment should not only focus on bone status, but also on the risk of falls. Additionally, it has been noted that disability arising from osteoporotic fractures, even when these fractures are not identified clinically, can translate into psychosocial symptoms and a poorer perception of health-related quality of life (HRQoL). The primary aim of the present study was to investigate if a composite model comprising: calcaneal QUS, falls risk and HRQoL assessments, can identify a group of elderly women at high risk of osteoporotic fracture from those at lower risk. One hundred and four community-dwelling women (mean age 71.3 ±5.8 years) were recruited for this study. These women underwent a series of tests that included: DXA bone mineral density (BMD) evaluation of the proximal femur and lumbar spine (L1 L4); calcaneal QUS measurement; spinal radiography; rasterstereographic back surface curvature (BSC) examination; and performance-based assessment of strength, mobility and balance. The women were classified into a `High Risk’group or a `Low Risk’ group using three separate classification criteria: i) low BMD, based on the World Health Organisation (WHO) recommended T-score of < -2.5, and⁄or a history of fragility fracture (Osteoporotic [OP] group versus Non-Osteoporotic [NOP] group); ii) presence of at least one radiographically identified prevalent vertebral fracture (Vertebral Fracture [VF] group versus Non-Vertebral Fracture [NVF] group); or iii) a history of either forearm or wrist fracture (Forearm/Wrist Fracture [WF] group versus Non-Forearm/Wrist Fracture [NWF] group)
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Ajwani, Shilpi. "Periodontal disease in an aged population, and its role in cardiovascular mortality." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/hamma/vk/ajwani/.

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Lee, Kwok-lun, and 李國綸. "The oral epidemiology of 45-64 year-old Chinese residents of a housingestate in Hong Kong: coronal and rootcaries." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B38628260.

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Eriksson, Margaretha. "The Impact of Birth Weight on Cardiovascular Risk Factors, Coronary Heart Disease and Prostate Cancer : Population-based Studies of Men Born in 1913 and Followed up Until Old Age." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6005.

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Books on the topic "Kidney diseases in old age"

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F, Faubert Pierre, ed. Renal disease in the aged. Boston: Little, Brown, 1991.

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A, Sessa, ed. Glomerulonephritis in the elderly. Basel: Karger, 1993.

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G, Porush Jerome, ed. Renal disease in the elderly. 2nd ed. New York: M. Dekker, 1998.

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Conference on Integrating Geriatrics into Nephrology (1998 Jasper, Alta.). Nephrology and geriatrics integrated: Proceedings of the Conference on Integrating Geriatrics into Nephrology held in Jasper, Alberta, Canada, July 31-August 5, 1998. Dordrecht: Kluwer Academic Publishers, 2000.

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United States. Congress. Senate. Special Committee on Aging. Kidney dialysis patients: A population at undue risk? : hearing before the Special Committee on Aging, United States Senate, One Hundred Sixth Congress, second session, Washington, DC, June 26, 2000. Washington: U.S. G.P.O., 2000.

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Skin disease in old age. 2nd ed. London: Dunitz, 1999.

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Skin disease in old age. Philadelphia: J.B. Lippincott Co., 1987.

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Spilsbury, Louise. Health and disease: From birth to old age. Chicago, Ill: Capstone Heinemann Library, 2013.

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America, Prevent Blindness. Vision problems in the U.S.: Prevalence of adult vision impairment and age-related eye diseases in America. [Schaumburg, IL]: The Society, 2002.

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America, Prevent Blindness. Vision problems in the U.S.: Prevalence of adult vision impairment and age-related eye diseases in America. [Schaumburg, IL]: The Society, 2002.

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Book chapters on the topic "Kidney diseases in old age"

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Wirnsberger, Gerhard. "Kidney Disease in Old Age." In Practical Issues in Geriatrics, 151–59. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-61997-2_16.

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Sinay, Isaac, and Felipe Inserra. "Chronic kidney disease related to diabetes in older patients." In Diabetes in Old Age, 84–105. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781118954621.ch8.

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So, Sarah, Jessica Stevenson, and Vincent Lee. "Kidney Diseases in the Elderly." In Advanced Age Geriatric Care, 131–44. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-96998-5_16.

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Torra, R., C. Badenas, L. P�rez, X. Estivill, and A. Darnell. "Hypertension in Polycystic Kidney Disease Types 1 and 2 and Its Effect on the Age of Onset of End-Stage Renal Disease." In Hereditary Kidney Diseases, 28–30. Basel: KARGER, 1997. http://dx.doi.org/10.1159/000059886.

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da Veiga, Glaucia Luciano, Beatriz da Costa Aguiar Alves, Matheus Moreira Perez, Joyce Regina Raimundo, Jéssica Freitas de Araújo Encinas, Neif Murad, and Fernando Luiz Affonso Fonseca. "Kidney Diseases: The Age of Molecular Markers." In Advances in Experimental Medicine and Biology, 13–27. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63908-2_2.

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de Berker, David A. R., Bertrand Richert, and Robert Baran. "The Nail in Childhood and Old Age." In Baran & Dawber's Diseases of the Nails and their Management, 183–209. Oxford, UK: Blackwell Publishing Ltd., 2012. http://dx.doi.org/10.1002/9781118286715.ch4.

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Hayflick, Leonard. "Modulating Aging, Longevity Determination and the Diseases of Old Age." In Modulating Aging and Longevity, 1–15. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-0283-6_1.

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Maresova, Petra, Hana Tomaskova, and Kamil Kuca. "The Use of Simulation Modelling in the Analysis of the Economic Aspects of Diseases in Old Age." In Business Challenges in the Changing Economic Landscape - Vol. 1, 369–77. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22596-8_26.

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von Gunten, Armin, Eduardo Nogueira, Henk Parmentier, and Irênio Gomes. "Neurocognitive Disorders in Old Age: Alzheimer’s Disease, Frontotemporal Dementia, Dementia with Lewy Bodies, and Prion and Infectious Diseases." In Primary Care Mental Health in Older People, 251–98. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-10814-4_21.

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Meslé, France, and Jacques Vallin. "Causes of Death at Very Old Ages, Including for Supercentenarians." In Demographic Research Monographs, 69–84. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49970-9_7.

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AbstractThe causes of death reported on the death certificates of the oldest old are generally seen as unreliable, and as thus providing little useful information on the process leading to death. However, in advanced countries, a majority of the people who die each year are relatively old, and the level of detail provided on medical certificates about the causes of death among this older population is improving. At the same time, scholars are becoming increasingly interested in studying not just the initial cause of death, but multiple causes of death, thereby taking all of the information reported on the certificate into account. This study demonstrates that in a country like France, the cause-of-death pattern evolves regularly until around age 105. The share of people dying of circulatory diseases tends to be quite stable over the age range, while the share of individuals dying of cancer is declining, and the share of people dying of respiratory/infectious diseases is rising. Furthermore, among people who die at very old ages, a typology of multiple causes of death highlights the growing importance of ill-defined causes, while opening the door to an interesting discussion about the concept of cause of death in the supercentenarian population. Instead of representing an ill-defined cause, senility could be considered an actual cause of death. This suggests that daily care is more crucial to the survival of the oldest old than any conventional medical care or treatment. Supercentenarians tend to be so frail that any minor health event or brief lapse of attention on the part of their caregivers can be lethal.
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Conference papers on the topic "Kidney diseases in old age"

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Permadi, Zico, Maria Ekawati, and Citra Ayu Aprilia. "Correlation between Nutritional Status and Pneumonia among 6-59 Months Years Old in Tangerang, Banten." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.03.13.

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ABSTRACT Background: Pneumonia is still causing the most deaths among children in developing countries. This disesase often occurs in children under 5 years of age. Nutritional status is a factor that is closely related to infectious diseases such as pneumonia. This study aimed to examine the correlation between nutritional status and pneumonia among 6-59 months years old in Tangerang, Banten. Subject and Methods: A cross-sectional study was conducted at Pakuhaji Community Health Center, Tangerang, Banten, from January to February 2018. A total of 29 children under five were enrolled in this study. The dependent variable was pneumonia. The independent variable was nutritional status. The data were collected from direct measurement of the children under five and questtioner. The data were analyzed by Chi-square. Results: As many as 16 children under five (55.17%) had pneumonia, 7 children under five (24.13%) were malnutrition, 3 children under five (10.34%) were short, and 5 children under five (7.24%) were thin. Nutritional status based on weight for age and weight for height had differences in nutritional status with the incidence of pneumonia among children under five, and they were statistically significant (p< 0.001). Conclusion: Nutritional status is associate with the incidence of pneumonia among 6-59 months years old (children under five) in Tangerang, Banten. Keywords: pneumonia incidence rate, pneumonia, nutritional status, chidren under five Correspondence: Citra Ayu Aprilia. Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta. Email: citra.ayuaprilia@gmail.com. Mobile: +628122090545. DOI: https://doi.org/10.26911/the7thicph.03.13
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Naji, Foziyeh Esmaiel, Mohammed Ehlayel, Nader Al-Dewik, and Ahmed Malki. "Clinical Utility and Cost Effectiveness of Complement 3 and Complement 4 in different Clinical Subspecialties in Hamad Medical Corporation." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0161.

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Background: Complement system is one of ancient innate immune systems in our body fighting against pathogens and foreign bodies. Either one of its three pathways, classical, alternative or lectin activates it. Because of its role and importance in combating against different pathological conditions, it works through defined proteins including regulators and inhibitors. However, over or under stimulation of complement system can lead to various diseases. A number of analytical assays are used to measure complement proteins and its activation states considering complement 3 (C3), complement 4 (C4) as the most common test used. Objectives: Our aims are to study the clinical utility and cost effectiveness of C3 and C4 among different clinical subspecialties in Hamad Medical Corporation (HMC), Doha-Qatar. Design and methods: A retrospective study was conducted using electronic medical records to generate patient’s list from clinical immunology laboratory at HMC. Data on 326 patients were collected from 1st January till 31st March, 2017 and used as pilot study after omitting duplications. The data was studied for its demographical, disease categories, C3 and C4 test results. C3 and C4 test cost were calculated inside HMC and compared to other healthcare providers in country and abroad. Results: A total of 326 patients, 148 males and 178 females (M/F ratio:0.8:1), of age (mean age ±SD) of 36 ± 17.6 years. 289(86%) were >15 years and 47(14%) were 15 or less. Kidney diseases (34%), autoimmune diseases (25%), and allergic diseases (18%) were the top 3 diseases, and constituted 77% of all diseases. 45/336 (13.4%) showed low C3, C4, or both. Mean levels of C3 (±SD) was 120.8 ±36.3 mg/dl, and C4 was27.85±11.9 mg/dl. High C3 and C4 levels were observed in 53 (15.7%) of patients. The cost of performing one test either C3 or C4 in HMC is 22 QR ($6), while other healthcare providers inside the country costed 150-300 QR ($41.2-$82.4). Conclusion: Autoimmune diseases, renal diseases and joist diseases were the most common diseases with low C3 and C4 levels. Although the cost of a single test of C3 or C4 is low, the total annual cost is huge. The treating physician is recommended to exercise judicious clinical wisdom when ordering C3 or C4 tests as diagnostic tools
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Mojarrad, Mehran. "Nanotechnology Based Cancer Therapies." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38034.

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By all accounts cancer remains the leading cause of death for humans of age less than 85 years old. This is partly because of the fact that there has been success in addressing other competing diseases such as cardiovascular leading to an overall drop in the rate of such disease where as after four decades of research success in cancer therapy remains limited. This places a greater demand on developing new therapies to treat cancer. With recent advances in nanotechnology field as applied in medicine there are new opportunities to detect, more effectively target and treat cancer and monitor the therapy while minimizing the damage to normal tissues and cells.
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Khurana, Anil, Paramjeet Kaur, Ashok K. Chauhan, Yashpal Verma, and Nupur Bansal. "Extra ovarian adult granulosa cell tumor of omentum: A report of a rare entity." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685372.

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Aims: Extra ovarian granulosa cell tumor (GCT) is extremely rare tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. A case of extra ovarian granulosa cell tumor of omentum in a 69 year old female presented here. Materials and Methods: A 69 years old postmenopausal, hypertensive female presented with complaints of pain in right lumber and iliac region of one month duration. Pain was off and on and intermittent. The patient had a history of hysterectomy 12 years ago for fibroid uterus. Results: Ultrasound examination of abdomen showed a hypoechoic lesion of size 78.1 mm x 57.3 mm in right iliac fossa with mild thickening of surrounding omentum. Another hypoechoic lesion of size 36.7 mm x 22.9 mm was seen in retroperitoneal region in supero-medial aspect of right kidney. CECT abdomen showed heterogeneously enhanced nodular lesion of size 6.6 x 6.8 cm in right lumbar region, mild thickening of surrounded omentum also seen however there was no evidence of infiltration to bowel loop seen. Uterus was not visualized. PET CT whole body revealed mildly metabolically active enlarged nodes in the bilateral level ib an ii, metabolically active large lobulated heterogeneously enhancing soft tissue density lesion in right lumbar region with non enhancing areas of necrosis. The lesion is closely abutting the anterior abdominal wall musculature antero laterally and small bowel loop medially surrounding mesenty shows increased vascularity and haziness. Colonoscopy findings were normal. Trucut biopsy of mass right lumbar region was positive for malignancy likely Round cell Sarcoma. A provisional diagnosis of retroperitoneal sarcoma of right lumbar region was made. She underwent exploratory laparotomy with excision of tumor. As per Operative findings there was approximately 8 x 7 cm, firm, omental mass present right to midline, arising from under surface of greater omentum. Ovaries were normal. Gross examination of omental mass showed nodular mass measuring 8 x 5 x 6 cm. External surface was multinodular and cut surface was grey brown to grey yellow with solid cystic areas and areas of necrosis. Microscopic examination of specimen showed Extraovarian Adult granulosa cell tumor/metastasis from occult granulose cell tumor. On IHC Vimentin, CK, SMA, Inhibin were positive, Ki67:15%, ER/PR were also positive and are negative for calretinin, thromobomodulin. Extensive necrosis was seen. After that she underwent rexploration and total omenectomy. HPE showed fat necrosis in omentum. All investigation showed no evidence of tumor in ovaries and at any other primary site then the patient finally diagnosed as having Granulosa cell tumor involving only omentum post op stage III C. Then patient was given six courses of chemotherapy with Inj Paclitaxel and Inj Carboplatin three weekly. Now patient is on regular follow up and disease free. Conclusion: Extra ovarian adult granulosa cell tumor of omentum is rare tumor. Multimodal treatment approaches including surgery, multi-agent chemotherapy may provide a survival benefit for patients.
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Al Thani, Sharifa, Munass Mohammed, and Hanaa Ahmed. "Factors associated with Vitamin D Deficiency in Women: Lesson from Biobank in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0190.

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Background: Vitamin D deficiency is affecting the health of humans around the world, and different factors associated with it were studied among different populations. Vitamin D deficiency was studied more often as a predictor to diseases. However, certain factors that could be associated with vitamin D deficiency were not explored among women, specifically in Qatar. Objective: To explore potential risk factors of vitamin D deficiency among women aged 20 to 65, using a sample of records from women volunteers to Qatar Biobank. Hypothesis: The study potential factors (age, BMI, education, income, milk consumption, occupation, pregnancy, physical activity and soft drinks) are associated with vitamin D deficiency. Methodology: We assessed some potential risk factors to vitamin D deficiency using data from Qatar Biobank (n=1000). Women aged 20-65 years old were included in the study. Univariate and multiple logistic regression models were used to model the association between our study potential factors (age, BMI, education, income, milk consumption, occupation, number of children, physical activity, and soft drinks) and being vitamin D deficient. Analysis was conducted using Stata (IC) version 15.0. Results: 654 women out of 1000 had vitamin D deficiency (serum level<20ng/mL), and 346 women that had normal level of vitamin D (serum level>20ng/mL). Vitamin D deficiency was significantly associated with women who drank soda 1-3 per month (p-value= 0.038) and 1-3 per week or more (p-value= 0.021). Also, women who were 41-50 years old (p-value= 0.006), 50 years and older (p-value= 0.000) and women who were students as their occupation (p-value= 0.003). Conclusion: Vitamin D deficiency was common among women in Qatar, as found in the present study. Students, women who drank soda, and younger age (<50) had the highest vitamin D deficiency
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Киреева, Виктория, Viktoriya Kireeva, Г. Лифшиц, G. Lifshic, Н. Кох, N. Koh, Ю. Усольцев, Yu Usolcev, Константин Апарцин, and Konstantin Apartsin. "Advantages of a personalized approach to the prevention and treatment of cardiovascular diseases in the staff of the INC Of the SBRAS." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec9ed47.

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Purpose of the study. To test the functional associations of polymorphic variants of genes in the regulation of blood pressure and vascular tone in employees of the ISC SB RAS. Materials and methods. The study involved patients, employees of the ISC SB RAS, being under care of the outpatient clinic of the Hospital of the ISC SB RAS. During routine laboratory testing the patients were taken 2 ml of blood for genetic analysis and further molecular genetic study on “Hypertension”, “Endothelial dysfunction”, “Pharmacogenetics”, “Inflammatory response” panels. Results. In the analysis of 12 genes coding for key proteins of hormonal enzyme blood pressure regulation systems, polymorphism of CYP11B2 showed statistically significant correlation with the presence of arterial hypertension, which makes its further study promising. The presence of allele C showed protective significance in relation to the development of hypertension with OR = 0,247. When checking associations of functional polymorphic variants of genes, the products of which are involved in the regulation of vascular tone, with hypertension in patients younger than 50 years old we found association of T/T rs5443GNB3 genotype with the debut of hypertensive disease under the age of 50. The data obtained allow the doctor to choose the most personalized and effective safe drug from certain groups, as well as its dose for employees having passed molecular genetic testing. These data can reveal predisposition to the most widespread and socially significant diseases in the surveyed subjects and provide specific personalized recommendations for the prevention of these diseases.
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Ahmed S. Hussein, Mai, Mohamed Attia, and Noha Mohamed. "Child-resistant features of pharmaceutical packaging in the egyptian and global market; a comparative study." In 10th International Symposium on Graphic Engineering and Design. University of Novi Sad, Faculty of technical sciences, Department of graphic engineering and design,, 2020. http://dx.doi.org/10.24867/grid-2020-p39.

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Child-Resistant packaging is substantial requirement especially when it is related to pharmaceuticals. Children under five years old are the most groups in risk of drug poisoning, as a result of their constant passion and attracting their attention to medicines, especially the distinctive color and small size. Due to the presence of medicines for adults, especially chronic diseases that require the presence of the drug always at home with exciting properties for the passion of a young child who is affected by colors and the small size which they can insert easily into their mouths. The child-resistant features attached to packages may present a problem (e.g., how to open the package) to its potential user (child or adult). Many of these features are used with the primary packaging and less for the secondary ones. Are these features efficient with available cost or not. Evaluation of each one might be varied according to package structure, level and child behavior. Therefore, the importance of adding some features in the pharmaceutical packaging Child-Resistant, in order to achieve the safety of children with a targeted age (children under 5 years old). By adding these special properties to the pharmaceutical packaging it will affect the design of the pharmaceutical packaging. Finally, this paper aimed to review and evaluate the child resistant features & securing methods that are used with pharmaceutical products in the Egyptian market, with which are available globally, then make a comparison between them by description and analysis.
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Eltai, Nahla Omer, Lubna Abu Rub, Hana A. Mohamed, Asma A. Al Thani, Hamda Qotba, and Hadi M. Yassine. "Testing Air Quality of Primary Health Care Centers in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0125.

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Background: Poor indoor air quality results in significant adverse effects on human health. In particular, the hospital atmospheric environment requires high air quality to protect patients and health care workers against airborne disease including nosocomial infections. Monitoring and surveillance programs of air pollutants and communicable diseases are essential as they provide information on the effectiveness of occupational hygiene and hazard control, and beneficial in assessing risks to community and environment. Objectives: This study aims to identify, monitor and report the level of air borne bacteria at four PHCC canters in Doha. Methodology: Four primary Health Centers (HC) were selected for testing air quality namely, Qatar University HC (North of Doha), AlRayan HC (West of Doha), Um Ghualina HC (Centre of Doha) and Old airport HC (South of Doha). Three sublocations were tested in each health center including a triage room, lobby and outdoor sample; each centre was visited once a month. Two sampling methods were used in this study: Anderson impactor (viable method) and filtration method (non-viable method). Anderson six stages impactor (TISCH Environmental, USA) was used to collect airborne bacteria on nutrient agar plates. Then the samples were incubated at 37 o C for 24 - 48 hours. The average colony- forming units (CFU) of bacteria was calculated per cubic meter of air (CFU/m3 ). On the other hand, the SKC Button Sampler (SKC Inc. PA, USA) was used to collect the airborne bacteria using cellulose ester filters. The collected isolates will be identified by sequencing 16srRNA (Miseq) later. Preliminary results: According to our preliminary results, the smallest average number of bacteria in the air was detected in QU HC, 3.2 (CFU/m3 ). While the highest average number was 44.7 CFU/m3 detected in Old Airport HC. Al-Rayyan HC and Om Ghuilina HC exhibited 30 and 20 CFU/m3 sequentially. Conclusions: Our preliminary results depicted that the occupancy pattern, size, and age of the building affect the number of bacteria in the air. However, more samples will be collected for better statistical sample size and analysis. .In addition, the captured airborne bacteria will be identified by 16s r RNA sequencing later.
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Latifah, Leny, Yusi Dwi Nurcahyani, Suryati Kumorowulan, and Diah Yunitawati. "Iodine Deficiency Associated with Adolescent Cognitive Performance in Endemic Iodine Deficiency Endemic Area." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.24.

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ABSTRACT Background: Iodine deficiency is one of the most important public health problems in the world today, especially among children and pregnant women who are considered to be the highest-risk groups. These diseases hinder the socio-economic development of the affected areas. This study aimed to determine iodine deficiency associated with adolescent cognitive performance in endemic iodine deficiency endemic area. Subjects and Method: This is a cross-sectional study conducted in Bulu district, Temanggung. A sample of 120 adolescents range age 11-14 years old was selected by cluster sampling. The dependent variable was Cognitive performance. The independent variable was Iodine deficiency. The data were collected by questionnaire, measurement and assessment. This study was analyzed by multiple logistic regression. Results: On cognitive performance. Adolescent IQs are below average (69.2%), mathematics tests (64.2%), and Indonesian language tests are below average (47.5%). A total of (30.8%) adolescents showed insufficient iodine intake, goiter enlargement (30.2%), stunting (35%), and anemia (20.8%). The linear regression model on IQ showed goiter enlargement as a factor associated with decreased IQ, even after accounting for confounding factors (p = 0.013; R2 = 0.07). Subjects with goiter enlargement had lower mean IQ (Mean = 10.32). IQ was related to Indonesian achievement (p = 0.031; R2 = 0.13), while UIE (p = 0.031), father’s education (p = 0.011), and IQ (p <0.001) were identified as factors related to math test scores (R2 = 0.23). after accounting for confounding factors. Conclusion: Iodine deficiency is negatively associated with cognitive performance in areas of endemic infested iodine deficiency. Goiter enlargement, which is an indicator of long-term iodine deficiency status, correlates with IQ. UIE, which reflects current indicators of iodine deficiency status, affects academic achievement. The cognitive impact of iodine deficiency lasts into adolescence. Therefore, ensuring adequate iodine intake in adolescents is essential to optimize their cognitive performance. Keywords: cognitive performance, iodine deficiency, early adolescence, nutrition, nutrition Correspondence: Leny Latifah. Research and Development Center for Health, Magelang, Central Java, Indonesia. Email: lenylatifah1@gmail.com DOI: https://doi.org/10.26911/the7thicph.05.24
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