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Journal articles on the topic 'Kikuchi-Fujimoto disease (KFD)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Jamal, Al-Bishri. "Kikuchi Fujimoto Disease." Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 5 (January 2012): CMAMD.S9895. http://dx.doi.org/10.4137/cmamd.s9895.

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In order to determine the clinical significance of Kikuchi Fujimoto Disease (histiocytic necrotizing lymhadenitis) and to review the literature available on this condition, we selected the Medicine research papers in English language published between the years 1972 to 2011. Kikuchi Fujimoto Disease (KFD) is an uncommon, cosmopolitan, benign and self-limiting condition with higher Japanese and Asian prevalence. Most of the sufferers of KFD are young people who seek treatment because of having acute tender cervical lymphadenopathy, low grade fever and night sweats. Coagulative necrosis with amp

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2

Alakkad, Ashraf, and Mohamed Alakkad. "Kikuchi-Fujimoto disease." International Journal of Advances in Medicine 8, no. 9 (2021): 1419. http://dx.doi.org/10.18203/2349-3933.ijam20213248.

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A lady from Sudan was referred to our medical clinic as a case of cervical lymphadenopathy with gradual enlargement. She had no complaint. The cervical lymphadenopathy was not associated with pain, fever, weight loss, cough, neither bleeding nor other associated swellings. There was no history of chronic medical problems including TB and underwent thorough investigations including LN biopsy. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphaden

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Djokic, Milomir, Vesna Begovic, Ivanko Bojic, Olga Tasic, and Dragana Stamatovic. "Kikuchi-fujimoto disease." Vojnosanitetski pregled 60, no. 5 (2003): 625–30. http://dx.doi.org/10.2298/vsp0305625d.

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Kikuchi-Fujimoto disease (KFD), also know as histiocytic necrotizing lymphadenitis, is a benign disorder characterized histologically by necrotic foci surrounded by histiocytic aggregates, and with the absence of neutrophils. KFD was recognized in Japan, where it was first described in 1972. The disease is most commonly affecting young women. The cause of the disease is unknown, and its exact pathogenesis has not yet been clarified. Many investigators have postulated viral etiology of KFD, connecting it with Epstein Barr virus, human herpes simplex virus 6 parvo B 19, but also with toxoplasmic

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Perry, Anamarija M., and Sarah M. Choi. "Kikuchi-Fujimoto Disease: A Review." Archives of Pathology & Laboratory Medicine 142, no. 11 (2018): 1341–46. http://dx.doi.org/10.5858/arpa.2018-0219-ra.

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Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by subacute necrotizing lymphadenopathy and frequently associated with fever. Young adults of Asian ancestry are most commonly affected, but it has been reported worldwide. Despite many studies in the literature, the cause of KFD remains uncertain. Histologically, KFD is characterized by paracortical lymph node expansion with patchy, well-circumscribed areas of necrosis showing abundant karyorrhectic nuclear debris and absence of neutrophils and eosinophils. Three evolving histologic patterns—proliferative, necrotizing, and xanthoma

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Dr., Gunja Jain, Mayank Gupta Dr., Laxmikant Goyal Dr., Jai Purohit Dr., and Sudhir Mehta Dr. "KIKUCHI-FUJIMOTO DISEASE (KFD): A Rare Case Report." International Multispeciality Journal of Health 3, no. 7 (2017): 223–25. https://doi.org/10.5281/zenodo.837955.

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<strong><em>Abstract—</em></strong><em> Kikuchi-Fujimoto disease (KFD) is a rare disease. It has a worldwide distribution with a higher prevalence in Asians. KFD is usually a self limiting disease and benign in nature. Clinically it presents as regional cervical lymphadenopathy and sometimes may presents as generalized lymphadenopathy as well. Night sweats and low grade fever may also be associated in some cases. A case of a 36 year old female had attended in SMS Hospital. She presented with fever, weight loss and tender cervical lymph nodes. Diagnostic significance of KFD lies in that it may

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Sousa, Alexandre de Andrade, João Marcos Arantes Soares, Marco Homero de Sá Santos, Marcelo Portes Rocha Martins, and José Maria Porcaro Salles. "Kikuchi-Fujimoto disease: three case reports." Sao Paulo Medical Journal 128, no. 4 (2010): 232–35. http://dx.doi.org/10.1590/s1516-31802010000400011.

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CONTEXT: Kikuchi-Fujimoto disease (KFD) manifests in most cases as unilateral cervical lymphadenomegaly, with or without accompanying fever. The disease mainly affects young women and has a self-limited course. It is more common in oriental countries, with few reports of its occurrence in Brazil. KFD should be included in the differential diagnosis of suspected cases of viral infections, tuberculosis, reactive lymphadenitis, systemic lupus erythematosus and metastatic diseases. It can be histologically confused with lymphoma. The disease is benign and self-limiting and an excisional biopsy of

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Rezayat, Talayeh, Matthew B. Carroll, Bryan C. Ramsey, and Andria Smith. "A Case of Relapsing Kikuchi-Fujimoto Disease." Case Reports in Otolaryngology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/364795.

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Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis was first described in Japan in 1972. It is described as a benign syndrome most commonly involving cervical lymphadenopathy, fever, and night sweats. The etiology of KFD is unknown but it is thought to be triggered by an autoimmune or viral process with an exaggerated T-cell-mediated immune response. KFD can mimic other serious conditions such as lymphoma, systemic lupus erythematosus (SLE), herpes simplex, and Epstein Barr virus. Diagnosis is confirmed histopathologically. Kikuchi’s disease is typically reported to have a

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García, Carlos E., Harsha V. Girdhar-Gopal, and David M. Dorfman. "Kikuchi-Fujimoto Disease of the Neck Update." Annals of Otology, Rhinology & Laryngology 102, no. 1 (1993): 11–15. http://dx.doi.org/10.1177/000348949310200103.

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Kikuchi-Fujimoto disease (KFD) is a rare entity of uncertain cause that commonly presents with persistently enlarged cervical lymph nodes unresponsive to antibiotic therapy. Although it usually follows a benign course, KFD has been repeatedly misdiagnosed as malignant lymphoma; hence, clinicians and pathologists alike need to be aware of this disease entity. The newest developments regarding the etiology and course of KFD are presented through a review of the literature and a recent illustrative case.

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Pandit, Sudarshan, Nilesh Wasekar, Tejas Sakale, Rahul Bhagwat Patil, Sandeep Ramchandra Kamble, and Amogh Jagtap. "An atypical rare neurologic complication of histiocytic necrotizing lymphadenitis (Kikuchi–Fujimoto Disease)." Medicover Journal of Medicine 1, no. 2 (2024): 106–10. http://dx.doi.org/10.4103/mjm.mjm_7_24.

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Kikuchi–Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare disease first reported in 1972 by Kikuchi and Fujimoto et al. It is more common in young females under 30 years of age. It is a self-limited disease characterized by cervical lymphadenopathy. Headache accompanied by fever is a common symptom of this disease; however, the central nervous system (CNS) can also be involved. CNS involvement in KFD is extremely rare and remains a diagnostic challenge. We describe a KFD patient with aseptic meningitis who had a headache as the first symptom of aseptic meni

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Baig, Shadab Ali, Dibya Falgoon Sarkar, and Debanwita Dutta. "Intravenous dexamethasone for the treatment of Kikuchi-Fujimoto disease." Journal of Oral Research and Review 16, no. 1 (2024): 57–60. http://dx.doi.org/10.4103/jorr.jorr_46_22.

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Abstract Kikuchi-Fujimoto disease (KFD) is a self-limiting disease of unknown etiology. The diagnosis of KFD is challenging as it shares a resemblance with many viral, autoimmune, and neoplastic diseases. KFD generally presents with histiocytic necrotizing lymphadenitis involving multiple cervical lymph nodes. The authors present a rare case report of a recurrent case of KFD in a 49-year-old female patient. Intravenous dexamethasone, hydroxychloroquine, and nonsteroidal anti-inflammatory drugs were used for controlling the initial symptoms, and later, oral methylprednisolone was used as a main

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Tadikonda, Rama Rao, Dulam Nandini Goud, and Kummari Sneha Deepika. "A Case Report on Kikuchi Disease." International Journal of Health Sciences and Research 13, no. 8 (2023): 182–86. http://dx.doi.org/10.52403/ijhsr.20230825.

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Kikuchi-Fujimoto disease (KFD) is a rare benign (non-cancerous, non-malignant) and self-limited syndrome characterized by regional lymphadenopathy with tenderness, predominantly in the cervical region, which is usually accompanied by mild fever and night sweats. It is first described in Japan and reported in 1972 simultaneously by two pathologists named Kikuchi and Fujimoto. Symptoms include weight loss, vomiting, nausea and sore throat. It is an auto immune disorder. Its etiology is still unknown. It is diagnosed by obtaining a biopsy specimen from lymph node. There is no specific treatment f

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Waghray, Jyotika. "A case report on Kikuchi disease." International Journal of Otorhinolaryngology and Head and Neck Surgery 8, no. 8 (2022): 681. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20221887.

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<p class="abstract">Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limited disease that mainly affects young women. Patients present with localized lymphadenopathy, fever, and leukopenia in up to half of the cases. KFD can occur in association with systemic lupus erythematosus. We present the case of a patient with KFD and systemic lupus erythematosus. A 38 years old female presented with right sided cervical lymphadenopathy, fever and a rash on the face, with a loss of apetite and generalized body weakness. After a series of investigations

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Pehlivan, Belma, Muammer Karagoz, Seyda Belli, Fatma Tokat, and Yesim Saglican. "Kikuchi-fujimoto disease: histopathological and clinical review of a case." Medical Science and Discovery 2, no. 2 (2015): 190–92. https://doi.org/10.36472/msd.v2i2.55.

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Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is an idiopathic, benign, self-limited, rare disease. This disease is mostly encountered in Asia and in young adult. Cervical lymph node involvement is the most common symptom. In addition, fever, fatigue, increase in erythrocyte sedimentation rate, and leukocytopenia may also occur. A specific diagnosis and treatment for this disease has not been defined. The diagnosis of this disease however can be diagnosed with excision of lymph node and histopathological examination. KFD can often resolve spontaneously. If there is no

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Islam, Mohammad Rafiqul, Abul Hayat Manik, Jannat Jeeba, Mohammod Omar Kasru, Rakib Hasan Mohammed, and Md Robed Amin. "Systemic Lupus Erythematosus Simulating Kikuchi Fujimotos Disease: A Case Report." Journal of Bangladesh College of Physicians and Surgeons 32, no. 4 (2015): 231–34. http://dx.doi.org/10.3329/jbcps.v32i4.26112.

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Kikuchi Fujimotos disease (KFD) is a rare, immunemediated, self-limiting disorder with unique histopathological features. KFD is usually seen in young Asian females; however, cases have been reported throughout the world and in all ethnicities. It has been recognized that there is a rare association between Systemic Lupus Erythematosus (SLE) and KFD via sporadic case reports. The exact pathophysiological relationship between these two diseases is still unclear. We report a case of a young Asian female who presented with persistent fever followed by development of lymphadenopathy and was diagn

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Nishimura, Yoshito, Midori Filiz Nishimura, Chikako Sakao, et al. "Clinicopathological Features of Kikuchi-Fujimoto Disease: Retrospective Observational Study." Blood 144, Supplement 1 (2024): 5371. https://doi.org/10.1182/blood-2024-200286.

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Introduction: Kikuchi-Fujimoto disease (KFD), is a rare inflammatory disease of unknown etiology, typically presenting with transient fever and cervical lymphadenopathy. It is recently classified as a tumor-like lesion in the World Health Organization Classification 5th Edition. There are few large-scale studies on patient demographics and clinical course. This study aims to report detailed clinicopathological features of KFD. Methods: We reviewed 112 cases of KFD diagnosed at Okayama University Department of Pathology and Oncology, Okayama, Japan between 2012 and 2022. Patients who were diagn

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Veer, Vikrant, Albert Lim, and Wolfgang Issing. "Kikuchi-Fujimoto Disease: A Case Report and Literature Review." Case Reports in Otolaryngology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/497604.

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Case. 38-year-old lady was referred to the ENT clinic with history of right-sided facial pain, otalgia, and odynophagia. Clinical examination revealed enlarged right-sided lymph nodes in the neck. Further radiological scans showed a mass near the carotid and enlarged level V lymph nodes. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotising lymphadenitis.Literature Review. Kikuchi-Fujimoto disease (KFD) was described in 1972 as lymphadenitis with focal p

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Ikeda, Kohsuke, Eiichi Kakehi, Seiji Adachi, and Kazuhiko Kotani. "Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination." BMJ Case Reports 15, no. 11 (2022): e250601. http://dx.doi.org/10.1136/bcr-2022-250601.

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A previously healthy Japanese woman in her 20s was admitted to our hospital with a 2-week history of fever (39.0°C) and a 1-week history of painful cervical lymphadenopathy. The day before fever onset, she had received her first Pfizer-BioNTech SARS-CoV-2 vaccine in her left arm. She had previously been treated with empirical antibiotics with no improvement. Physical examination revealed painful lymphadenopathy in both posterior cervical regions. CT showed symmetrical lymphadenopathies in the neck, supraclavicular, axillary and inguinal regions as well as hepatosplenomegaly. We suspected lymph

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Horino, Taro, Osamu Ichii, and Yoshio Terada. "Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus?" Romanian Journal of Internal Medicine 57, no. 1 (2019): 72–77. http://dx.doi.org/10.2478/rjim-2018-0028.

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Abstract Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by cervical lymphadenopathy and fever. Since KFD was first reported in 1972, the validity of this clinical entity has been controversial and its aetiology remains unknown. Herein, we report a case of a patient with KFD, which was believed to be associated with systemic lupus erythematosus.

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Alavandar, Aishwarya, and Koushik Muthu Raja Mathivanan. "Think beyond TB lymphadenitis - Kikuchi fujimoto lymphadenitis." IP Indian Journal of Immunology and Respiratory Medicine 9, no. 2 (2024): 71–74. http://dx.doi.org/10.18231/j.ijirm.2024.014.

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Kikuchi-Fujimoto disease (KFD) is an extremely unusual lymphadenopathy that typically affects females between the ages of 20 and 40, but the aetiology is still unclear. A 28-year-old female presented with right-sided cervical lymph nodes, but there was no history of fever, anorexia, or loss of appetite. Ultrasonography of the patient's neck revealed bilateral cervical lymphadenopathy. Both the acid-fast bacilli smear and GeneXpert tests returned negative results. Histopathology revealed the presence of lymphocytes and histiocytes mixed with karyorrhectic debris. Immunohistochemistry markers su

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Darda, Shubham, Aarjuv Majmundar, Puneet Upadhyay, Harshita H. Nouni, Sucheta Lakhani, and Jitendra D. Lakhani. "A Rare Case of Kikuchi-Fujimoto Disease in an Indian Female." Asian Journal of Medicine and Health 21, no. 11 (2023): 97–101. http://dx.doi.org/10.9734/ajmah/2023/v21i11923.

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Kikuchi-Fujimoto disease is a self-limiting illness characterised by non-specific symptoms, most commonly reported symptoms being fever and lymphadenopathy. Unknown in its cause, Kikuchi-Fujimoto disease (KFD) is a benign, uncommon disorder usually presenting under the age of 30 years in women. This disease is mainly seen in Asian population mainly in Japan but it is rare in Indian population. The etiological cause of this disease remains unknown. This condition needs to differentiated from other closely resembling conditions such as tuberculosis, lymphoma, Systemic Lupus Erythematosus (SLE) a

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Masiak, Anna, Amanda Lass, Jacek Kowalski, Adam Hajduk, and Zbigniew Zdrojewski. "Self-limiting COVID‐19-associated Kikuchi‐Fujimoto disease with heart involvement: case-based review." Rheumatology International 42, no. 2 (2022): 341–48. http://dx.doi.org/10.1007/s00296-021-05088-8.

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Abstract Background The association between COVID-19 infection and the development of autoimmune diseases is currently unknown, but there are already reports presenting induction of different autoantibodies by SARS-CoV-2 infection. Kikuchi-Fuimoto disease (KFD) as a form of histiocytic necrotizing lymphadenitis of unknown origin. Objective Here we present a rare case of KFD with heart involvement after COVID-19 infection. To our best knowledge only a few cases of COVID-19-associated KFD were published so far. Based on presented case, we summarize the clinical course of KFD and its association

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He, Jie, Rui-ping Li, Jian-hua Wang, and Bao-An Chen. "The Clinical and Histological Characterization of Malignant Lymphoma, Kikuchi-Fujimoto Disease and L-Forms Acid-Fast Bacillus Infection." Blood 112, no. 11 (2008): 5275. http://dx.doi.org/10.1182/blood.v112.11.5275.5275.

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Abstract Objective: Malignant lymphoma (ML), Kikuchi-Fuljimoto disease (KFD) and L-forms Acid-fast bacillus infection (L-forms TB) usually affect the cervical lymph nodes. KFD and L-form TB are often confused with ML and take misdiagnosis and inappropriate treatment. The diagnosed of these diseases is on basis of an excision biopsy of affected lymph nodes. Methods: We analyzed 63 patients (including case diagnosed in our hospital) by clinical characteristic, laboratory, pathological morphology, histochemistry and immunohistochemistry. Results: Of 63 cases, 43 were ML, 17 were KFD and 3 were L-

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Sandakly, Nicolas, Georgio El Koubayati, Jeannette Sarkis, Samah Naderi, Delivrance Sebaaly, and Fady Haddad. "Kikuchi-Fujimoto disease associated with a flare-up of a leukocytoclastic vasculitis: A rare case report and review of literature." Medicine 103, no. 13 (2024): e37626. http://dx.doi.org/10.1097/md.0000000000037626.

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Rationale: Kikuchi-Fujimoto disease (KFD) also known as histiocytic necrotizing lymphadenopathy is an exceedingly rare cause of cervical lymphadenopathy, commonly accompanied by systemic symptoms such as fever, fatigue, night sweats, myalgia, skin rash. Patient concerns: In this paper, we report the case of a 22-year-old female patient who experienced a flare-up of leukocytoclastic vasculitis that was complicated by the appearance of a cervical lymph node with dysphagia, fever and nausea. Diagnosis: Infectious and autoimmune workup came back negative. Interventions: Excisional lymph node biops

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Camins-Fàbregas, J., V. Ortiz-Santamaria, N. Busquets-Pérez, et al. "AB1051 KIKUCHI FUJIMOTO DISEASE, IS IT SLE?" Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1815.3–1816. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5460.

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Background:Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by adenopathies and fever. It raises a broad differential diagnosis that includes lymphoproliferative disorders, infections and systemic autoimmune diseases, and diagnostic confirmation is always by histology, which shows histiocytic necrotizing lymphadenitis. Although its course is generally benign and self-limited, it can be associated both at the time of diagnosis and during follow-up with systemic autoimmune diseases, the most frequent of which is systemic lupus erythematosus (SLE).Objectives:To describre the clinical

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Lakmali, Nalika, Ranga Chamara, Tiron Chathuranga, and Meththananda Herath. "Recurrent Kikuchi Fujimoto Disease with Aseptic Meningitis and Familial Occurrence: A Rare Presentation." Anuradhapura Medical Journal 17, no. 3 (2023): 40–44. http://dx.doi.org/10.4038/amj.v17i3.7775.

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Recurrent Kikuchi Fujimoto Disease (KFD) with neurological manifestations is a rare entity. It usually presents with fever and cervical lymphadenopathy. Diagnosis is based on clinical grounds and typical histological findings of lymph node biopsy. Mostly KFD is self-limiting. Treatment with non-steroidal anti-inflammatory drugs or steroids may be needed in severe recurrent disease.We report a case of recurrent KFD in a 28-year-old male presenting with aseptic meningitis who has a family history of KFD.

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Poornima Raj, Ravina Ravi, Roshni P R, and Jayakumar C. "A Rare Necrotizing Lymphadenitis: Kikuchi-Fujimoto Disease." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 7600–7602. http://dx.doi.org/10.26452/ijrps.v11i4.4021.

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Kikuchi-Fujimoto disease also known as necrotizing lymphadenitis is a rare, self limiting cause of lymphadenitis with unknown etiology and pathogenesis. The clinical signs and symptoms include cervical lymphadenopathy, fever, less frequent chills, night sweats, arthralgia, rash, weight loss and symptoms of respiratory infections. Diagnosis is often based on histopathological studies involving lymph node. It is often misdiagnosed with SLE, Lymphoma etc. There is no treatment guidelines given for KFD after diagnosis it is often limited to treat the symptoms but in severe cases corticosteroids ca

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GRANİT SEMAVİ, Deniz, and Turgay ULAŞ. "Highlighting steroid indications for Kikuchi Fujimoto disease: a case report." Cukurova Medical Journal 47, no. 4 (2022): 1753–55. http://dx.doi.org/10.17826/cumj.1176368.

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Kikuchi Fujimoto disease (KFD) is a rare, generally benign and self limited condition with an unknown etiology. There isn’t a guideline for treatment of KFD, recommendations for treatment are based on clinical experience and management is typically supportive. However, sometimes more ominous course of the disease may be experienced. Thus, for the patients with severe disease, refractory symptoms and recurrences, more definite and efficient treatment options are required. Here, we aimed to emphasize the indications of steroid treatment via a case of KFD resolved after systemic steroids.

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Singla, Sushil, Mohitesh Kumar, Vinod Kumar Jat, and Deepika Parwan. "Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?" International Journal of Contemporary Pediatrics 8, no. 9 (2021): 1602. http://dx.doi.org/10.18203/2349-3291.ijcp20213326.

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Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment.

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Adiody, Supriya, Krishnanand Krishnakumar, and Jeena Chimmen. "Unmasking Kikuchi Disease: A Rare Treatable Cause of Lymphadenopathy." Pulmon 26, no. 3 (2024): 105–7. https://doi.org/10.4103/pulmon.pulmon_30_24.

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Abstract Kikuchi–Fujimoto disease (KFD) is a rare, benign disease characterized by histiocytic nonnecrotizing, self-limiting lymphadenopathy. It is usually seen in females of Asian lineage. The diagnosis is made by excision biopsy of the lymph node with characteristic histopathologic findings of KFD. Misdiagnosis may lead to the patient being wrongly treated with antituberculosis medications or be aggressively investigated for a lymphoma. Here, we present the case of a young female presenting with evening rise of temperature and lymphadenopathy who was diagnosed to have KFD.

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Shadrach, Benhur Joel, Lexmi Priya Raju, Asma Bibi, Kunal Deokar, Priyanka Gaikwad, and Jinish Doshi. "Human papilloma virus vaccine induced Kikuchi-Fujimoto disease: A case report." Lung India 42, no. 3 (2025): 256–59. https://doi.org/10.4103/lungindia.lungindia_557_24.

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ABSTRACT Cervical lymphadenopathy can be due to numerous causes. The common causes include reactive and infections conditions in children and malignancy in the elderly. Kikuchi-Fujimoto disease (KFD) is a rare cause of cervical lymphadenopathy. As viral vaccines contain viral antigens, they can trigger the development of KFD. The human papillomavirus (HPV) vaccine can trigger KFD. It is important to elicit a history of prior vaccination to identify the trigger in patients with necrotising histiocytic lymphadenitis suspected of having KFD. We hereby report a case of a 16-year-old female who was

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Sarfraz, Shiza, Hamza Rafique, Hassam Ali, and Syed Zawahir Hassan. "Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy." F1000Research 8 (August 4, 2021): 1652. http://dx.doi.org/10.12688/f1000research.19981.2.

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Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosi

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Sarfraz, Shiza, Hamza Rafique, Hassam Ali, and Syed Zawahir Hassan. "Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy." F1000Research 8 (September 17, 2019): 1652. http://dx.doi.org/10.12688/f1000research.19981.1.

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Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosi

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Otiv, Madhumati, Pawan Shah, Abhijeetbotre Botre, and Kannan Subramaniyan. "Kikuchi Fujimoto disease with macrophage activation syndrome, seizures, and pleuritis in a young child." International Journal of Contemporary Pediatrics 10, no. 11 (2023): 1729–32. http://dx.doi.org/10.18203/2349-3291.ijcp20233246.

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Kikuchi Fujimoto disease (KFD) is rare in children and generally a benign, self-limiting disease that rarely runs a complicated course. We report a rare case of KFD in a young girl that had a complicated course with macrophage activation syndrome (MAS), posterior reversible encephalopathy syndrome (PRES) and pleuritis needing ventilatory support and prolonged immunosuppression with good recovery. This illustrates KFD can rarely also have unusual presentation needing advanced immunosuppression and a careful follow up.

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Deb, Arunima, Vielka Fernandez, Ekim Kilinc, et al. "Kikuchi–Fujimoto Disease: A Case Series and Review of the Literature." Diseases 12, no. 11 (2024): 271. http://dx.doi.org/10.3390/diseases12110271.

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Kikuchi–Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, self-limiting disorder characterized by fever typically lasting for 1 week up to 1 month and painful necrotizing lymphadenopathy, primarily affecting young adults of Asian ancestry. Although the exact cause remains unclear, infectious and autoimmune mechanisms have been implicated in the pathogenesis of the disease. In this case series, we aim to describe the histopathological features of KFD over a ten-year period at Mount Sinai Medical Center of Florida, and review the current understanding of its

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Gunawardena, Nithya, and Chandani Udagedara. "Lymphadenopathy in systemic lupus erythematosus manifesting as Kikuchi disease." Ceylon Medical Journal 68, no. 4 (2023): 188–91. https://doi.org/10.4038/cmj.v68i4.9915.

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Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease with multisystem involvement. Lymphadenopathy in SLE is multifactorial. A rare aetiology is Kikuchi-Fujimoto disease (KFD) characterized by fever and tender lymphadenopathy. Here we present a case of a 54-year-old lady with SLE and lymphadenopathy who was ultimately diagnosed as KFD. This case shows the importance of clinicopathological correlation in SLE patients presenting with lymphadenopathy as it may significantly change the management.

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Dr., Hamza Sümter*. "KIKUCHI DISEASE IN ALPHA THALASSEMIA: CASE REPORT AND BRIEF REVIEW." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 957–63. https://doi.org/10.5281/zenodo.15303175.

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Alpha thalassemia develops due to defects in the alpha gene. The clinical spectrum of alpha thalassemia ranges from asymptomatic cases to intrauterine demise. Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, was first described in the 1970s. It presents with painful enlargement of the affected lymphoid tissue and fever. Its etiopathogenesis remains unclear, and diagnosis is based on morphology. KFD is a self-limiting benign disease. Although rare, its true prevalence is unknown. This study presents a case of Kikuchi disease in a patient with alpha thalassemi

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Vilaca, Ana, Vanessa Palha, and Teresa Pimentel. "Kikuchi–Fujimoto disease: A rare cause of lymphadenopathy and fever." Case Reports International 6, no. 2 (2017): 31–34. http://dx.doi.org/10.5348/crint-2017-39-cr-7.

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Introduction: Kikuchi–Fujimoto disease (KFD) was originally described in a young woman and is a rare, benign and self-limited condition of unknown cause, usually characterized by cervical lymphadenopathy and fever. The diagnosis of KFD is made by lymph node biopsy and treatment is only symptomatic, with signs and symptoms usually resolving within one to six months. Case Report: A 31-year-old female, rabbit breeder, presented with complaints of fever, facial and hand skin lesions for 10 days. Physical examination revealed nose, malar, scalp, fingers and pinna erythematous papules; also painful

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Fauzi, Luqman Safwan, Vidhi Unadkat, Siti Nadhirah Binti Abd Hadi, and Ciro Rinaldi. "Case of Kikuchi-Fujimoto disease associated with multiple myeloma." BMJ Case Reports 14, no. 5 (2021): e241391. http://dx.doi.org/10.1136/bcr-2020-241391.

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We present a 47-year-old, South-African origin, woman with a background of stable monoclonal gammopathy of unknown significance (MGUS) who attended A&E with a history of coryzal symptoms associated with persistent fever, lymphadenopathy and a new onset of rash, not responding to antibiotics and paracetamol. A trial of high-dose steroids resolved symptoms. Bone marrow biopsy confirmed a progression of MGUS into multiple myeloma and her axillary lymph node biopsy analysis supported a diagnosis of Kikuchi-Fujimoto disease (KFD). This is an unusual presentation where KFD has been noted alongsi

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Cannon, Laura, Endi Wang, and Mara Becker. "Diagnosis of Kikuchi-Fujimoto disease in an 11-year-old girl with fever and sickle cell disease." BMJ Case Reports 13, no. 8 (2020): e234302. http://dx.doi.org/10.1136/bcr-2020-234302.

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Kikuchi-Fujimoto disease (KFD) is a rare lymphohistiocytic disorder which can cause prolonged fever and other systemic B symptoms including diffuse lymphadenopathy. Given its clinical presentation, there is often initial concern for lymphoma and diagnosis requires lymph node biopsy. It most frequently affects young women of Asian descent; it is less commonly encountered in paediatric patients. KFD is typically a benign, self-limited process, however, there is an association with development of systemic lupus erythematosus. Given its rarity, it remains unclear if KFD is associated with other ch

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Louis, N., M. Hanley, and N. McD Davidson. "kikuchi–Fujimoto disease: a report of two cases and an overview." Journal of Laryngology & Otology 108, no. 11 (1994): 1001–4. http://dx.doi.org/10.1017/s0022215100128749.

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AbstractKikuchi-Fujimoto disease (KFD) has been widely reported from Japan and sporadically from many parts of the world including Saudi Arabia, since its original description in 1972 but the disease remains poorly known by clinicians. In this paper we report two Saudi patients seen in Tabuk. Saudi Arabia. One was a 36-year-old Saudi man and the other a 16-yearold Saudi girl. Both presented with cervical lymphadenopathy and pyrexia. Histological examination of biospy material from both showed classical features of KFD. Other laboratory findings were unremarkable except for leucopenia. Followin

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Servatyari, Karo, Hero Yazdanpanah, and Chamara Dalugama. "Rare Presentation of Self-Limiting Kikuchi–Fujimoto Disease in Relapsing Nature." Case Reports in Medicine 2020 (September 21, 2020): 1–4. http://dx.doi.org/10.1155/2020/9785104.

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Background. Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. The disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Recurrence of KFD is reported rarely. Case Presentation. A 56-year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. The excision biopsy of the cervical lymph nodes

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Zhang, Y., L. Ding, L. Aftab, and P. Rushton. "A Rare Case Of Kikuchi-Fujimoto Disease Displaying Chromosomal Abnormality." American Journal of Clinical Pathology 154, Supplement_1 (2020): S106. http://dx.doi.org/10.1093/ajcp/aqaa161.232.

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Abstract Introduction/Objective Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease (KFD), is a rare and benign self-limiting process primarily affecting 20~35-year-old Asian women with spontaneous remission after weeks to months of illness. Although the involvement of T cell-mediated immune response, infections, and HLA class II gene have been proposed as possible etiologies, the detailed pathogenesis has not been elucidated. Very few literatures exhibited KFD displaying chromosomal abnormality such as t(2:16). Methods Here, we report a rare case of KFD with novel ka

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Bhuiyan, Md Jahangir Hossain, and Latifa Akhter. "Kikuchi-Fujimoto Disease, a rare cause of cervical lymph adenopathy." Bangladesh Journal of Medical Science 13, no. 2 (2014): 212–14. http://dx.doi.org/10.3329/bjms.v13i2.18305.

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Kikuchi-Fujimoto Disease (KFD) present with Dysphagia, fever and lymphadenopathy. A young adult Bangladeshi female presented with fever and cervical lymphadenopathy. Broad-spectrum antibiotic (3rd generation oral cephalosporin) were given but no improvement after one month. FNAC suggested non specific lymphadenitis. Later on, excision biopsy of cervical lymph node was done and histopathology suggested KFD. Oral prednisolone was given showing improvement and no relapse was en-counted Awareness of this disorder by clinicians and pathologists will help misdiagnosis and inappropriate treatment. DO

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Tariq, Hassan, Vinaya Gaduputi, Arsalan Rafiq, and Roopalekha Shenoy. "The Enigmatic Kikuchi-Fujimoto Disease: A Case Report and Review." Case Reports in Hematology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/648136.

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We report this case of a 33-year-old African American woman who presented to the clinic with preauricular and submandibular masses that she had noticed 6 weeks earlier. She gave a remote history of noticing bilateral cervical masses 3 years prior to this presentation that had not been investigated at the time and resolved spontaneously. Excisional biopsies of the cervical lymph nodes showed morphologic and immunophenotypic findings suggestive of Kikuchi Fujimoto disease (KFD). KFD is an uncommon, self-limited, and perhaps an underdiagnosed entity with an excellent prognosis. It mimics malignan

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Selivanov, M., L. Turgunova, A. Zinchenko, and O. Bruner. "KIKUCHI-FUJIMOTO DISEASE: THE FIRST CLINICAL OBSERVATION OF A RARE CASE IN KAZAKHSTAN." Oncologia i radiologia Kazakhstana 67, no. 1 (2023): 50–53. http://dx.doi.org/10.52532/2663-4864-2023-1-67-50-53.

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Relevance: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare underlying cause of benign lymphadenopathy, typically accompanied by fever and fatigue. Diagnosing this rare condition causes difficulties. Even though more than half a century has passed since the first described case, KFD is still hard to diagnose. Therefore it is of utmost importance to perform all the necessary diagnostic tests to avoid misdiagnosing and prescribing the wrong and often too-aggressive treatment. This article describes the first clinical case of KFD in the Republic of Ka

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Selivanov, M., L. Turgunova, A. Zinchenko, and O. Bruner. "KIKUCHI-FUJIMOTO DISEASE: THE FIRST CLINICAL OBSERVATION OF A RARE CASE IN KAZAKHSTAN." Oncologia i radiologia Kazakhstana 67, no. 1 (2023): 50–53. http://dx.doi.org/10.52532/2521-6414-2023-1-67-50-53.

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Relevance: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare underlying cause of benign lymphadenopathy, typically accompanied by fever and fatigue. Diagnosing this rare condition causes difficulties. Even though more than half a century has passed since the first described case, KFD is still hard to diagnose. Therefore it is of utmost importance to perform all the necessary diagnostic tests to avoid misdiagnosing and prescribing the wrong and often too-aggressive treatment. This article describes the first clinical case of KFD in the Republic of Ka

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Padmasiri, M. S. N., and M. I. Mujaheith. "Lateral rectus palsy as the first presentation of Kikuchi Fujimoto’s disease." Asian Journal of Internal Medicine 3, no. 2 (2024): 113–17. http://dx.doi.org/10.4038/ajim.v3i2.171.

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Kikuchi Fujimoto’s Disease (KFD) or histiocytic necrotising lymphadenitis is recognised as a disease with a benign and indolent course. The common clinical symptoms of KFD include fever, headache, arthralgia and cervical lymphadenopathy. The diagnosis is based on clinical grounds and histological findings of lymph node biopsy. Kikuchi disease presenting with neurological manifestations is seldom seen. Out of all reported neurological manifestations, aseptic meningitis, brainstem encephalitis and cerebellar ataxia are common. We report a case of a 16 year old girl presenting with right sided la

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Basnet, Srijana, Laxman Shrestha, and Prabina Shrestha. "Kikuchi Fujimoto as an Initial Presentation of Systemic Lupus Erythromatosis." Journal of Nepal Paediatric Society 41, no. 1 (2021): 99–102. http://dx.doi.org/10.3126/jnps.v41i1.29519.

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    Kikuchi-Fujimoto Disease (KFD) is a rare benign, condition of necrotising histiocytic lymphadenitis. In this case report, we discuss a case of 10 year old male patient who presented with a fever, rash and generalised lymphadenopathy that was not attributable to the more common causes. Axillary lymph node biopsy confirmed the diagnosis of KFD. Treatment with prednisolone improved his symptoms but after six months he had recurrence of his symptoms. He was investigated again and finally met diagnostic criteria for SLE. This case report highlights importance of close fo

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Gunasundari, V., Jasmine S. Sundar, Srinivas G, and C. Nitheeshwar. "Unveiling Kikuchi-fujimoto disease in systemic lupus erythematosus: Case report and comprehensive review of literature." Indian Journal of Case Reports 10, no. 11 (2024): 371–73. http://dx.doi.org/10.32677/ijcr.v10i11.4754.

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Kikuchi-Fujimoto disease (KFD) also referred to as histiocytic necrotizing lymphadenitis is an uncommon, non-malignant condition with unknown etiology. The diagnosis of KFD was hampered by the similarity to lymphoma, viral infections, and other autoimmune diseases. We present a 43-year-old female with a history of systemic lupus erythematosus (SLE) with a history of low-grade fever for 10 days, associated with chills, rigors, and pain over the posterior aspect of the neck with swelling. An excisional biopsy of the cervical lymph node confirmed the diagnosis of KFD. KFD should be considered in

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Soto-Moreno, Alberto, Francisco Vílchez-Márquez, María Narváez-Simón, et al. "Pediatric Kikuchi–Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood." Dermatopathology 12, no. 1 (2025): 7. https://doi.org/10.3390/dermatopathology12010007.

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Kikuchi–Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendritic cells but notably lacks neutrophils and eosinophils. Recent evidence reveals a notable prevalence among pediatric patients, who may exhibit distinct features compared to adults. We reported the case of an 11-year-old girl presenting with persistent fever, cervical adenopathy, and a malar rash, leading to a diagnosis of KFD following lymph node biopsy, wh

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