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Relevant bibliographies by topics / Killer immunoglobulin like receptors (KIR)

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Academic literature on the topic 'Killer immunoglobulin like receptors (KIR)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Killer immunoglobulin like receptors (KIR)"

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Hidajat, Melanny, Dominik Selleslag, Achiel Van Hoof, Jan Van Droogenbroeck, Johan Billiet, and Arnold Criel. "Killer Immunoglobulin-Like Receptors (KIRs) Genotypes in a Belgian Population." Blood 104, no. 11 (November 16, 2004): 3852. http://dx.doi.org/10.1182/blood.v104.11.3852.3852.

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Abstract KIRs (Killer cell Immunoglobulin-like Receptors) are expressed on NK (Natural Killer) cells and a subpopulation of T lymphocytes namely memory CD8+ T cells. The distribution of KIR genes varies among individuals and populations. These genes are encoded on chromosome 19 (19q13.4). Till now 17 KIR genes and pseudogenes have been identified. KIRs recognise groups of HLA class I alleles. NK activity is partially controlled through the interaction between KIRs and their HLA ligands. Several studies report that KIRs may affect the outcome of Hematopoietic Stem-Cell Transplantations. We perf

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Cremer, Anja, Ute Heider, Stefan Tomiuk, Andreas Arendt, Jurgen Schmitz, Andreas Bosio, Volker Huppert, and Christian Biervert. "Integrated Genotyping and mRNA Expression Profiling of Killer Immunoglobulin-Like Receptors." Blood 106, no. 11 (November 16, 2005): 3909. http://dx.doi.org/10.1182/blood.v106.11.3909.3909.

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Abstract Natural killer (NK) cells belong to a subgroup of lymphocytes (CD3-CD56+) which play an important role in the cellular immune response against virus-infected cells and tumors. The activity of NK cells is regulated by a balance of triggering and inhibitory receptors, including Killer Ig-like Receptor (KIR) molecules which interact with specific HLA class I molecules, predominantly HLA-C, on target cells. The 17 known KIR genes are divided into two classes: activating KIRs and inhibitory KIRs. There is strong evidence that inhibitory KIR mismatch between donor and recipient improves the

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Luc-Aimé, Kagoué Simeni, Yindom Louis-Marie, Loni Ekali Gabriel, Clauvis Kunkeng Yengo, F. Esemu Livo, and Nguedia Jules Clement Assob. "Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon." Journal of Immunology Research 2021 (January 13, 2021): 1–7. http://dx.doi.org/10.1155/2021/9053280.

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The biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS control programs. This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. The primary aim of this stu

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Parham, Peter, Paul J. Norman, Laurent Abi-Rached, and Lisbeth A. Guethlein. "Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules." Philosophical Transactions of the Royal Society B: Biological Sciences 367, no. 1590 (March 19, 2012): 800–811. http://dx.doi.org/10.1098/rstb.2011.0266.

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In placental mammals, natural killer (NK) cells are a population of lymphocytes that make unique contributions to immune defence and reproduction, functions essential for survival of individuals, populations and species. Modulating these functions are conserved and variable NK-cell receptors that recognize epitopes of major histocompatibility complex (MHC) class I molecules. In humans, for example, recognition of human leucocyte antigen (HLA)-E by the CD94:NKG2A receptor is conserved, whereas recognition of HLA-A, B and C by the killer cell immunoglobulin-like receptors (KIRs) is diversified.

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Treanor, Bebhinn, Peter M. P. Lanigan, Sunil Kumar, Chris Dunsby, Ian Munro, Egidijus Auksorius, Fiona J. Culley, et al. "Microclusters of inhibitory killer immunoglobulin–like receptor signaling at natural killer cell immunological synapses." Journal of Cell Biology 174, no. 1 (June 26, 2006): 153–61. http://dx.doi.org/10.1083/jcb.200601108.

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We report the supramolecular organization of killer Ig–like receptor (KIR) phosphorylation using a technique applicable to imaging phosphorylation of any green fluorescent protein–tagged receptor at an intercellular contact or immune synapse. Specifically, we use fluorescence lifetime imaging (FLIM) to report Förster resonance energy transfer (FRET) between GFP-tagged KIR2DL1 and a Cy3-tagged generic anti-phosphotyrosine monoclonal antibody. Visualization of KIR phosphorylation in natural killer (NK) cells contacting target cells expressing cognate major histocompatibility complex class I pro

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Abi-Rached, Laurent, and Peter Parham. "Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues." Journal of Experimental Medicine 201, no. 8 (April 18, 2005): 1319–32. http://dx.doi.org/10.1084/jem.20042558.

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Expression of killer cell Ig-like receptors (KIRs) diversifies human natural killer cell populations and T cell subpopulations. Whereas the major histocompatibility complex class I binding functions of inhibitory KIR are known, specificities for the activating receptors have resisted analysis. To understand better activating KIR and their relationship to inhibitory KIR, we took the approach of reconstructing their natural history and that of Ly49, the analogous system in rodents. A general principle is that inhibitory receptors are ancestral, the activating receptors having evolved from them b

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Rettman, Pauline, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura España-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, and Salim I. Khakoo. "Peptide: MHC-based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors." Journal for ImmunoTherapy of Cancer 9, no. 5 (May 2021): e001912. http://dx.doi.org/10.1136/jitc-2020-001912.

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BackgroundNatural killer (NK) cells are increasingly being recognized as agents for cancer immunotherapy. The killer cell immunoglobulin-like receptors (KIRs) are expressed by NK cells and are immunogenetic determinants of the outcome of cancer. In particular, KIR2DS2 is associated with protective responses to several cancers and also direct recognition of cancer targets in vitro. Due to the high homology between activating and inhibitory KIR genes to date, it has been challenging to target individual KIR for therapeutic benefit.MethodsA novel KIR2DS2-targeting therapeutic peptide:MHC DNA vacc

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Rajagopalan, Sumati, and Eric O. Long. "Understanding how combinations of HLA and KIR genes influence disease." Journal of Experimental Medicine 201, no. 7 (April 4, 2005): 1025–29. http://dx.doi.org/10.1084/jem.20050499.

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Combinations of HLA and killer cell immunoglobulin–like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA–KIR gene combinations beg for a better understanding of the underlying mechanisms.

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Diaz-Peña, Roberto, Patricia Mondelo-Macía, Antonio José Molina de la Torre, Rebeca Sanz-Pamplona, Víctor Moreno, and Vicente Martín. "Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer." Cells 9, no. 2 (February 24, 2020): 514. http://dx.doi.org/10.3390/cells9020514.

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Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Colorectal carcinoma (CRC) is one of the most common types of inflammation-based cancer. The purpose of the present study was to investigate the presence of KIR genes and HLA class I and II alleles in 1074 CRC patients and 1272 controls. We imputed data from single-nucleotide polymorphism (SNP) Illumina OncoArray to identify associations at HLA (HLA–A, B

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Harvey, D., J. J. Pointon, C. Sleator, A. Meenagh, C. Farrar, J. Y. Sun, D. Senitzer, D. Middleton, M. A. Brown, and B. P. Wordsworth. "Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis." Annals of the Rheumatic Diseases 68, no. 4 (November 19, 2008): 595–98. http://dx.doi.org/10.1136/ard.2008.095927.

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Objectives:To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS).Methods:14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the χ2 test.Results:KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS an

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Dissertations / Theses on the topic "Killer immunoglobulin like receptors (KIR)"

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Yindom, Louis Marie. "Human Leukocyte Antigen (HLA) and Killer Immunoglobulin-like Receptors (KIR) in HIV-2 Infection." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520671.

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Braun, Kali. "Association of killer immunoglobulin-like receptor (KIR) genes with tuberculosis disease in two Canadian cohorts." PLoS ONE, 2013. http://hdl.handle.net/1993/22042.

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In Canada, and more specifically in Canadian-born Aboriginals and foreign born populations, high incidence of tuberculosis (TB) causes significant morbidity and mortality. The presence or absence of specific killer immunoglobulin-like receptor (KIR) genes, individually or in conjunction, may be associated with tuberculosis (active, latent, or uninfected disease status) as well as ethnicity of an individual. It is hypothesized that the differences in KIR profiles, gene frequencies, and/or haplotypes in Canadian-born Aboriginal, Canadian-born non-Aboriginal, and foreign born individuals elicits

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Sepulveda, Christian Alberto Garcia. "Killer cell Immunoglobulin-like Receptor (KIR) polymorphism : functional implications and clinical relevance." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444690/.

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NK cell function is regulated by Killer-cell Immunoglobulin-like Receptors (KIR) some of which recognise class I Major Histocompatibility Complex molecules. KIRs have been shown to exhibit a high degree of functional diversity which is generated at several levels. However, the functional relevance of this diversity remains largely unknown. This thesis describes our approach towards elucidating the functional relevance of KIR diversity. To study this we first compiled all known KIR sequences into a database. We developed bioinformatics tools to facilitate the study of these sequences and have m

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Halfpenny, Iris A. "An investigation into the genetics of the killer immunoglobulin-like receptor (KIR) gene family." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494359.

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Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.

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[Truncated abstract] Natural killer (NK) cell alloreactivity can be exploited in haploidentical haematopoietic stem cell transplantation (HSCT) to improve graft survival, reduce graft versus host disease and decrease leukaemic relapse. NK cells lyse cells that have reduced expression of class I HLA molecules. In an allogeneic setting, donor NK cells may be activated by the absence of donor (self) class I HLA molecules on recipient cells; the absence of self-epitopes being detected by inhibitory KIR receptors on donor NK cells. The way in which genetic polymorphism of the receptors and ligands

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Salim, Patrícia Hartstein. "Estudo do polimorfismo dos genes KIR na esclerose sistêmica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/15457.

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As células Natural Killer (NK) fazem parte da resposta imune inata, sendo a primeira linha de defesa do organismo contra vírus, bactérias, tumores e microorganismos. Estas células induzem a morte da célula-alvo quando não há o reconhecimento das moléculas de antígenos leucocitários humanos (HLA) de classe I, através de seus receptores, chamados Killer cell Immunoglobulin-like Receptor (KIR). Vários estudos demonstram o envolvimento dos genes KIR na patogênese das doenças auto-imunes. Acredita-se que combinações desses genes possam ser favoráveis para o desenvolvimento da esclerose sistêmica (E

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Ishida, Yoshihiro. "Killer immunoglobulin-like receptor genotype did not correlate with response to anti-PD-1 antibody treatment in a Japanese cohort." Kyoto University, 2020. http://hdl.handle.net/2433/253207.

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Silva, Pamela Portela da. "Análise de polimorfismos dos genes KIR e HLA classe I em pacientes com câncer colorretal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/148088.

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O câncer colorretal (CCR) pode ocorrer em qualquer parte do cólon ou do reto e representa o terceiro câncer mais comum no mundo em ambos os sexos. As células Natural Killer (NK) fazem parte do sistema imune inato reconhecendo moléculas de HLA de classe I em células alvo, através de seus receptores de membrana killer cell immunoglobulin-like receptors (KIR). O objetivo deste estudo foi avaliar a associação entre os genes KIR e os ligantes HLA em pacientes com câncer colorretal e controles saudáveis. Examinamos o polimorfismo de 16 genes KIR e seus ligantes HLA em 154 pacientes caucasóides com C

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Silva, Pamela Portela da. "Estudo de polimorfismos dos genes KIR e HLA em pacientes com câncer de próstata." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/35890.

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O câncer de próstata é o segundo câncer mais comum entre homens, uma vez que tanto a incidência como a mortalidade aumentam exponencialmente após a idade de 50 anos. As células Natural Killer (NK) fazem parte do sistema imune inato e reconhecem moléculas de HLA de classe I na célula alvo, através de seus receptores de membrana, chamados killer immunoglobulin-like-receptors (KIR). O objetivo desse estudo foi avaliar a associação entre os genes KIR e HLA em pacientes com câncer de próstata e grupo controle. Genotipamos 200 pacientes com diagnóstico de câncer de próstata e 185 pacientes saudáveis

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Ichise, Hiroshi. "NK cell alloreactivity against KIR-ligand-mismatched HLA-haploidentical tissue derived from HLA haplotype-homozygous iPSCs." Kyoto University, 2017. http://hdl.handle.net/2433/228232.

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Book chapters on the topic "Killer immunoglobulin like receptors (KIR)"

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Hou, Lihua, Minghua Chen, Noriko Steiner, Kanthi Kariyawasam, Jennifer Ng, and Carolyn K. Hurley. "Killer Cell Immunoglobulin-Like Receptors (KIR) Typing by DNA Sequencing." In Methods in Molecular Biology™, 431–68. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-842-9_25.

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Li, Hongchuan, Paul W. Wright, and Stephen K. Anderson. "Identification and Analysis of Novel Transcripts and Promoters in the Human Killer Cell Immunoglobulin-like Receptor (KIR ) Genes." In Methods in Molecular Biology, 377–91. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-362-6_26.

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Long, Eric O., Deborah N. Burshtyn, Christopher C. Stebbins, and Carsten Watzl. "How do killer cell Ig-like receptors inhibit natural killer cells?" In Activating and Inhibitory Immunoglobulin-like Receptors, 235–41. Tokyo: Springer Japan, 2001. http://dx.doi.org/10.1007/978-4-431-53940-7_29.

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Rajalingam, Raja, Sarah Cooley, and Jeroen van Bergen. "Killer Cell Immunoglobulin-Like Receptors in Clinical Transplantation." In Manual of Molecular and Clinical Laboratory Immunology, 1150–60. Washington, DC, USA: ASM Press, 2016. http://dx.doi.org/10.1128/9781555818722.ch119.

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Wang, Lawrence L., and Wayne M. Yokoyama. "Regulated expression of non-polymorphic gp49 molecules on mouse natural killer cells." In Activating and Inhibitory Immunoglobulin-like Receptors, 25–31. Tokyo: Springer Japan, 2001. http://dx.doi.org/10.1007/978-4-431-53940-7_4.

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Ghansah, Tomar, John M. Ninos, and William G. Kerr. "A role for the SH2-containing inositol phosphatase in the biology of natural killer cells and stem cells." In Activating and Inhibitory Immunoglobulin-like Receptors, 129–40. Tokyo: Springer Japan, 2001. http://dx.doi.org/10.1007/978-4-431-53940-7_17.

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Rajalingam, Raja, and Elham Ashouri. "Gene-Specific PCR Typing of Killer Cell Immunoglobulin-Like Receptors." In Methods in Molecular Biology, 239–55. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-493-7_12.

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Ruggeri, Loredana, Shuhong Zhang, and Sherif S. Farag. "Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation." In Cancer Treatment and Research, 47–69. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-78580-6_3.

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Pymm, Phillip, and Julian P. Vivian. "Production of Recombinant Killer Immunoglobulin-Like Receptors for Crystallography and Luminex-Based Assays." In Methods in Molecular Biology, 281–99. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7568-6_22.

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"Killer Immunoglobulin-Like Receptors (KIR)." In Encyclopedia of Signaling Molecules, 1001. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100688.

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Conference papers on the topic "Killer immunoglobulin like receptors (KIR)"

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Chan, Daniel C. F., Zhiyong Zhang, Hong Wang, Xiaomei Sui, Tiffany T. Y. Chan, Natalie Ahn, Joe Phillips, Kathryn Horwitz, Lewis Lanier, and Paul Bunn. "Abstract 3656: Therapeutic effects of anti-KIR antibodies against metastatic cancer cells with aberrant expression of Natural Killer-Cell Immunoglobulin-like Receptors (KIRs)." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3656.

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Wang, Enxiu, Liang-Chuan Wang, Ching-Yi Tsai, Vijay Bhoj, Steven Albelda, Edmund Moon, and Michael C. Milone. "Abstract B22: A chimeric antigen receptor (CARs) based upon a killer immunoglobulin-like receptor (KIR) triggers robust cytotoxic activity in solid tumors." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-b22.

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Rauf, Khairunnisa Abd, Erry Gumilar Dachlan, and Ariyanto Harsono. "Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia." In 2nd International Conference Postgraduate School. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0007542103210324.

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Chan, Daniel C., Zhiyong Zhang, Di Zheng, Tiffany Chan, Mary Berg, Kathryn Horwitz, Natalie Ahn, Lewis Lanier, and Paul Bunn. "Abstract 4836: Immune-tolerance due to aberrant expression of Natural Killer-Cell Immunoglobulin-like Receptors (KIRs) on cancer cells and enhanced cancer-platelet interactions." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4836.

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Chan, Daniel C., Zhiyong Zhang, Hong Wang, Xiaomei Sui, Tiffany T. Chan, Natalie Ahn, Lewis L. Lanier, and Paul A. Bunn. "Abstract 1357: Role of Natural Killer-cell Immunoglobulin-like receptors KIR2DL1 and KIR3DL1 in immune resistance." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1357.

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Nasef, SI, AM Asker, HH Omar, and HM Hassoba. "SAT0304 Stimulatory and inhibitory killer immunoglobulin-like receptors on natural killer T (NKT) cells in patients with systemic lupus erythematosus (SLE): relation to disease activity." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3920.

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Hagberg, N., D. Leonard, G. Nordmark, and L. Rönnblom. "PS1:16 The presence of autoantibodies to multiple killer cell immunoglobulin-like receptors is associated with nephritis in sle patients." In 11th European Lupus Meeting, Düsseldorf, Germany, 21–24 March 2018, Abstract presentations. Lupus Foundation of America, 2018. http://dx.doi.org/10.1136/lupus-2018-abstract.64.

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Reports on the topic "Killer immunoglobulin like receptors (KIR)"

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Varbanova, Viktoria, Snejina Mihailova, Elissaveta Naumova, and Anastasiya Mihaylova. Distribution of Killer-cell Immunoglobulin-like Receptors (KIR) and their HLA Class I Ligands in the Bulgarian Population. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, July 2020. http://dx.doi.org/10.7546/crabs.2020.07.14.

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