Relevant bibliographies by topics / Kinetics For Drug Release

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Academic literature on the topic 'Kinetics For Drug Release'

Author: Grafiati
Published: 7 June 2025
Last updated: 11 July 2025

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Journal articles on the topic "Kinetics For Drug Release"

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Chakraborty, Santanu, Madhusmruti Khandai, Anuradha Sharma, Ch Patra, V. Patro, and Kalyan Sen. "Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations." Acta Pharmaceutica 59, no. 3 (2009): 313–23. http://dx.doi.org/10.2478/v10007-009-0025-8.

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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.
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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decrease the dose – dependent side effects associated with repeated administration of conventional Rimopride Citrate Dihydrate dihydrate tablets. The cumulative drug release of innovators brand (MOZA SR, Intas Pharmaceuticals) of sustained release tablet of Rimopride Citrate Dihydrate were compared for in vitro dissolution study. The formulation F9 matrix tablet releases the drug appropriately in comparison of innovators brand. The cumulative drug release at the end of 24th hour from formulation F9 (98.01%) and the cumulative drug release at the end of 24th hour from innovators brand was (97.30%). The in vitro drug release result indicates that formulation F9 released more drug than innovators brand and hence more drug is available at the absorption site from formulation F9 as compared to innovators brand, hence the formulation F9 has better bioavailability than innovators brand of Rimopride Citrate Dihydrate sustained release matrix tablet and also the sustained release matrix tablet was found to be beneficial in terms of reduction in frequency of administration. The formulation F9 best suited with zero order release kinetics (corr.coefficient =0.943) than the first order release kinetics (corr. Coefficient = 0.910). The formulation F9 follows Higuchi model of drug release kinetics (corr. coefficient=0.41). The Koresmyer peppas drug release kinetics showed correlation coefficient (0.926) and release exponent (n) 0.724 which indicates that the drug release mechanism is non-fickanian diffusion. Hence it can be concluded that once daily sustain release matrix tablet of Rimopride Citrate Dihydrate having short half life, was found to exert a satisfactory sustained release profile which may provide an improved bioavailability, increased therapeutic efficacy and patient compliance.
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Kumar, Putta Rajesh, Meena N, Poojitha P, Sowjanya P, Shivaleela U, and Sharma JVC. "Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 51–63. http://dx.doi.org/10.32553/jbpr.v13i2.1084.

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Background: Venlafaxine Hydrochloride a serotonin, nor epinephrine reuptake inhibitor, oral antidepressant used to treat depression. Objective: The present study was aimed at studying controlled release of Venlafaxine Hydrochloride with Guargum, Hydroxy propyl methyl cellulose as matrix polymers, Micro crystalline cellulose as binder and Dicalcium phosphate as diluent filler. Methods: Tablets were studied for pre, post compression, swelling and in vitro dissolution studies. Drug release was analyzed by release kinetic models. Results: Preformulation studies revealed that the drug procured was pure. Analytical method was linear and precise. The rheological parameters were within the ideal limits and suitable for compression. Swelling index increased with increase in matrix polymer content. In vitro studies showed drug release, sustained for 18 to 24 h. Optimized formulation V5 released 14.32±0.430% in 2 h. At the end of 12 and 24 h it has released 49.37±0.685% and 98.31±0.435% of drug respectively and followed peppa’s kinetics with anomalous (Non fickian) diffusion mechanism of drug release. Discussion: The drug release from swollen gel matrix occurred initially by drug diffusion followed by polymer chain relaxation and erosion. The in vitro release kinetics from majority of formulations followed Peppa’s and zero order kinetics. The peppa’s n values indicated drug release via anomalous (non fickian) diffusion and super case II transport. Conclusion: Venlafaxine HCl release form tablets sustained up to 24 h which could provide better bioavailability and improved patient compliance. Keywords: Venlafaxine HCl, controlled release matrix tablets, guar gum, Hydroxy propyl methyl cellulose, In vitro studies, Release kinetics.
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Zhu, Weiwei, Jiajie Long, and Meiwu Shi. "Release Kinetics Model Fitting of Drugs with Different Structures from Viscose Fabric." Materials 16, no. 8 (2023): 3282. http://dx.doi.org/10.3390/ma16083282.

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(1) Background: It is simpler and more environmentally friendly to use supercritical CO2 fluid technology to process skincare viscose fabrics. Therefore, it is significant to study the release properties of drug-loaded viscose fabrics to choose suitable skincare drugs. In this work, the release kinetics model fittings were investigated in order to clarify the release mechanism and provide a theoretical basis for processing skincare viscose fabrics with supercritical CO2 fluid. (2) Methods: Nine kinds of drugs with different substituent groups, different molecular weights, and different substitution positions were loaded onto viscose fabrics using supercritical CO2 fluid. Then, the drug-loaded viscose fabrics were placed in an ethanol medium, and the release curves were drawn. Finally, the release kinetics were fitted using zero-order release kinetics, the first-order kinetics model, the Higuchi model, and the Korsmeyer–Peppas model. (3) Results: The Korsmeyer–Peppas model was the best-fitting model for all the drugs. Drugs with different substituent groups were released via a non-Fickian diffusion mechanism. On the contrary, other drugs were released via a Fickian diffusion mechanism. (4) Conclusions: In view of the release kinetics, it was found that the viscose fabric can swell when a drug with a higher solubility parameter is loaded onto it using supercritical CO2 fluid, and the release rate is also slower.
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Arefin, Paroma, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres." Bangladesh Pharmaceutical Journal 19, no. 1 (2016): 58–67. http://dx.doi.org/10.3329/bpj.v19i1.29240.

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The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded sustained release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In vitro dissolution study was performed spectrophotometrically according to USP paddle method using phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was significantly increased with the increase of drug loading. The drug release patterns were simulated in different kinetic orders such as zero order release kinetics, first order release kinetics, Higuchi release kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism and Higuchi release kinetics was found to be the predominant release mechanism. Morphological changes due to different drug loading were assessed by scanning electron microscopic (SEM) technique. Differential scanning calorimetry and fourier transform infra-red (FT-IR) spectroscopy was performed to evaluate compatibility of drug with the polymer. A statistically significant variation indrug encapsulation efficiency and release rate was observed for variation in drug loading.Bangladesh Pharmaceutical Journal 19(1): 58-67, 2016
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Mitran, Raul-Augustin, Daniela Berger, Jeanina Pandele-Cusu, and Cristian Matei. "Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics." Journal of Nanomaterials 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/9864396.

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Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small- and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro release profiles have been fitted using a three-parameter kinetic model and they have been explained in terms of the release rate during the burst and sustained release stages and the fraction of drug molecules released during the burst stage. The silica framework doping with aluminum was found to decrease the amount of drug released in the burst stage, without affecting the other kinetic parameters. The therapeutic agent release rates depend mainly on the pore size and volume of the mesoporous carriers and drug-loaded samples.
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Suprianto. "Analisis Kinetika Pelepasan Teofilin dari Granul Matriks Kitosan." JURNAL ILMIAH MANUNTUNG 2, no. 1 (2016): 70–80. https://doi.org/10.5281/zenodo.1246129.

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Moment the drug dosage form development, it is important to study the drug release or dissolution that is recognized as an element in drug development. Mathematical models could help optimize the design of drugs to produce models of drug release information. Analysis of quantitative values obtained when depicting dissolution drug release profiles more easily when the mathematical concepts used to describe the drug release kinetics model. The model release of drugs known includes zero order, first order, Higuchi models, models Hixon Crowell and Peppas Korsmeyer models. The purpose of this review applies mathematical concepts to study the phenomenon of the drug release theophylline granules matrix made from chitosan.
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Dumitriu, Raluca Petronela, Ana Maria Oprea, and Cornelia Vasile. "Kinetics of Swelling and Drug Release from PNIPAAm/Alginate Stimuli Responsive Hydrogels." Solid State Phenomena 154 (April 2009): 17–22. http://dx.doi.org/10.4028/www.scientific.net/ssp.154.17.

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Stimuli responsive hydrogels are very attractive for applications in sustained and/or targeted drug delivery systems. As the release of drugs is related to the swelling behavior of hydrogels, the swelling kinetic studies become of great importance to appreciate the release kinetics from hydrogel matrices. Hydrogels with high performance properties have been prepared from N-isopropylacryl amide (NIPAAm) and sodium alginate, crosslinked with N,N`-methylene-bis-(acrylamide) (MBAAm). This study is focused on the investigation of swelling and drug release kinetics, coupled by morphological studies. The kinetic parameters of the swelling at different temperatures for hydrogels samples have been evaluated and confirmed their temperature-responsive behavior. The swelling rate constant (ksw) decreases of with increasing temperature and slight increases with the alginate content in the samples. The drug release kinetic study from the prepared hydrogel matrices was performed in twice-distilled water and ethanol for bioactive agents as vanillin and ketoprofen, respectively. An increase of alginate content results in a slower rate and smaller percentage of vanillin and ketoprofen released. It has been established that the ketoprofen occurs according with case II of transport and vanillin release behavior occurs by an anomalous transport mechanism. The values of the release rate constant (kr) decreased by increasing swelling degree in case of 75/25 NIPAAm/alginate hydrogels and decreased also by increasing content of alginate in hydrogels with various compositions. Morphological studies performed by environmental scanning electron microscopy (ESEM) evidenced a relaxed network at high relative humidity, which explain both swelling and release profiles.
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Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

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Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out in the gastric medium (pH 1.3) for first two hours and then in the intestinal medium (pH 6.8) for 22 hours using United States Pharmacopoeia (USP) 22 paddle-type dissolution apparatus. The granules showed satisfactory flow properties, compressibility index etc. All the tablets complied with pharmacopoeial specifications. The results of dissolution studies indicated that the formulation F-5 and F-7 (up to 75.36 % drug release in 12 hours) could extend the drug release up to 12 hours. The drug release patterns were simulated in different kinetic orders such as Zero Order release kinetics, First Order release kinetics, Higuchi release kinetics, Korsmeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism. From the study we observed that Higuchi release kinetics was the predominant release mechanism than Zero Order and First Order kinetics. The drug release mechanism from the matrix tablets was found to be non Fickian mechanism. DOI: http://dx.doi.org/10.3329/dujps.v10i2.11785 Dhaka Univ. J. Pharm. Sci. 10(2): 87-92, 2011 (December)
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Loew, Stephan, Alfred Fahr, and Sylvio May. "Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers." Journal of Drug Delivery 2011 (June 7, 2011): 1–10. http://dx.doi.org/10.1155/2011/376548.

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Liposomes are frequently used as pharmaceutical nanocarriers to deliver poorly water-soluble drugs such as temoporfin, cyclosporine A, amphotericin B, and paclitaxel to their target site. Optimal drug delivery depends on understanding the release kinetics of the drug molecules from the host liposomes during the journey to the target site and at the target site. Transfer of drugs in model systems consisting of donor liposomes and acceptor liposomes is known from experimental work to typically exhibit a first-order kinetics with a simple exponential behavior. In some cases, a fast component in the initial transfer is present, in other cases the transfer is sigmoidal. We present and analyze a theoretical model for the transfer that accounts for two physical mechanisms, collisions between liposomes and diffusion of the drug molecules through the aqueous phase. Starting with the detailed distribution of drug molecules among the individual liposomes, we specify the conditions that lead to an apparent first-order kinetic behavior. We also discuss possible implications on the transfer kinetics of (1) high drug loading of donor liposomes, (2) attractive interactions between drug molecules within the liposomes, and (3) slow transfer of drugs between the inner and outer leaflets of the liposomes.
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Dissertations / Theses on the topic "Kinetics For Drug Release"

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Jones, Stephen Joseph. "Investigating nonlinear enzyme kinetics as an internal control system for nanoreactor drug release." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22207/.

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The improper administration of therapeutic compounds is not only financially inefficient, but, there exists a very real risk of harmful, or potentially life-threatening effects. To gain control, nano-drug delivery systems provide a discernible option for temporal and spatial regulation of drug bioavailability within the body. In current regimes, temporal control is realised through gradual release over an extended period of time, or triggered release in response to a change in the physiochemical environment. Of course, when considering the design of an ideal drug delivery system, we think of adaptivity – adaptivity to dynamically modulate drug release in response to a changing biological macroenvironment. In nature, this ability to sense, communicate, and respond is fundamental to the existence of any living organism, irrespective of complexity. In most instances, this responsiveness is achieved through feedback-controlled biochemical processes that work to regulate a functional process, and so, any “smart” delivery system would be smart to do the same. Of course, where conventional chemical feedback is concerned, potential toxicity and lack of biocompatibility, caused by inappropriate catalysts, is problematic, however, the emergence and enhanced understanding of enzymatic feedback provides an interesting and more compatible alternative. As such, this doctoral thesis focuses on drawing together two distinct entities of intense scientific focus, nonlinear enzyme kinetics and nanoreactor technology, and works towards the idealism of a feedback-controlled secondary response. To achieve this, through the utilisation of bottom-up synthetic chemistry, we have successfully built, investigated, and optimised a platform that has allowed up to systematically and extensively investigate the effect of confinement on an enzymatic feedback reaction. Through this process, we have uncovered a system more complicated than first anticipated. This complexity, driven firstly by the fragility of constituents in relatively harsh conditions, but more importantly by the dynamism of the system in terms of membrane transport, and associated pH-linked permeability coefficients. However, by building this platform, we have not only learned how to control the kinetic output of the reaction, but have gained an overview of how the system behaves as a whole. It is this organic discovery, and ultimate understanding, that has allowed us to extend our reach, pushing the functionality of our novel system, to achieve both temporally-controlled drug delivery and nano-motor-based vesicular propulsion.
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He, Xingyu. "Long-term Light-activated Drug Delivery Systems." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752062550859.

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Fugit, Kyle Daniel. "QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/37.

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Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal release kinetics of the anticancer agent topotecan. Mathematical modeling allowed simultaneous determination of drug permeability and interfacial binding to the bilayer from release data. This method also quantified the effects of topotecan dimerization and surface potential on total amount of drug released from these liposomal formulations. The pH-sensitive release of topotecan from unilamellar vesicles was subsequently evaluated with this method. A mechanistic model identified three permeable species in which the zwitterionic lactone form of topotecan was the most permeable. Ring-closing kinetics of topotecan from its carboxylate to lactone form were found to be rate-limiting for topotecan drug release in the neutral pH region. Models were also developed to non-invasively analyze release kinetics of actively-loaded liposomal formulations of topotecan in vivo. The fluorescence excitation spectra of released topotecan were used to observe release kinetics in aqueous solution and human plasma. Simulations of the intravesicular pH in the various release media indicated accelerated release in plasma was a consequence of increased intravesicular pH due to ammonia levels in the plasma instead of alterations in bilayer integrity. Further studies were performed to understand the roles of dimerization, ion-pairing, and precipitation on loading and release kinetics obtained from actively-loaded topotecan. Extension of this type of modeling for other types of nanoparticles was illustrated with doxorubicin-conjugated polymeric micelles. Mathematical modeling of experimental studies monitoring doxorubicin release identified conjugation stability during storage, hydrazone hydrolysis kinetics, and unconjugated doxorubicin partitioning affected micellar doxorubicin release. This work identifies several of the key parameters governing drug release from these liposomal and micellar nanoparticles and lays the framework for future development of in vivo release models for these formulations.
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Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gastro-retentive dosage forms have been the topic of interest in recent years as a practical approach in drug deliveries to the upper GI tract or for release prolongation and absorption. These dosage forms are particularly suitable for drugs that have local effects on the gastric mucosa in the stomach. Other candidates include drugs that are likely to be absorbed in the upper small intestine, or drugs that are unstable in basic environment of distal intestine and colon or those with low solubility at elevated pH conditions (i.e. weak bases). To develop a gastro-retentive delivery system the following steps were taken. First, to investigate the possible incompatibility issues between the model drug and excipients to be used for the delivery system. Stability and physicochemical properties of the active agent and its mixture with excipients were studied using analytical techniques such as Raman spectroscopy and Differential scanning calorimetry (DSC). No incompatibility issues were detected. Second, Kollidon SR as a relatively new release-rate controlling polymer was incorporated in the final formulation. For solid dosage form the ability of the final powder mix to flow well during manufacturing and the intrinsic characteristics that make it compressible are critical. The in-depth compaction study of Kollidon SR was assessed with the help of a compaction simulator. The flowability, swelling and erosion behavior together with release-rate retarding properties of Kollidon SR were also assessed. The final oral delivery system was based on Kollidon SR and Polyethylene Oxide (PEO) 303 as a monolithic matrix system. The noneffervescent monolithic matrix was made by direct compression. In vitro evaluation of the designed system released the active content in a near zero manner. The dosage form was bouyant in pH 2.0 acidic buffer with no floatation lag time which minimizes the possibility of early gastric emptying.
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Modi, Sweta. "The Critical Role of Mechanism-Based Models for Understanding and Predicting Liposomal Drug Loading, Binding and Release Kinetics." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/19.

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Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment. Membrane binding of the drug affects both drug loading and release from liposomes. The influence of bilayer composition and phase structure on the partitioning behavior of a model non-polar drug, dexamethasone, and its water soluble prodrug, dexamethasone phosphate, was evaluated. Consequently, a quantitative dependence of the partition coefficient on the free surface area of the bilayer, a property related to acyl chain ordering, was noted. The efficacy of liposomal formulations is critically dependent on the drug release rates from liposomes. However, various formulation efforts to design optimal release rates are futile without a validated characterization method. The pitfalls of the commonly used dynamic dialysis method for determination of apparent release kinetics from nanoparticles were highlighted along with the experimental and mathematical approaches to overcome them. The value of using mechanism-based models to obtain the actual rate constant for nanoparticle release was demonstrated. A novel method to improve liposomal loading of poorly soluble ionizable drugs using supersaturated drug solutions was developed using the model drug AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin), a poorly soluble camptothecin analogue. Enhanced loading with a drug to lipid ratio of 0.17 was achieved and the rate and extent of loading was explained by a mathematical model that took into account the chemical equilibria inside and outside the vesicles and the transport kinetics of various permeable species across the lipid bilayer and the dialysis membrane. Tunable liposomal release kinetics would be highly desirable to meet the varying therapeutic requirements. A large range of liposome release half-lives from 1 hr to 892 hr were obtained by modulation of intraliposomal pH and lipid composition using dexamethasone phosphate as a model ionizable drug. The mathematical models developed were successful in accounting for the change in apparent permeability with change in intraliposomal pH and bilayer free surface area. This work demonstrates the critical role of mechanism-based models in design of liposomal formulations.
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Cui, Yong. "Enhanced Release of Lidocaine From Supersaturated Solutions of Lidocaine In A Pressure Sensitive Adhesive." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054210962.

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Pavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.

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One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions, fits into the overall goal and complements the product development process. Our research focuses on the early preclinical stage of the drug development process involving lead selection, optimization and candidate identification steps. Our work helps in screening the most favorable candidates based on the biopharmaceutical and pharmacokinetic properties. This helps in precipitating early development failures in the early drug discovery and candidate selection processes and reduces the rate of late-stage failures, which is more expensive. In our research, we successfully integrated two well-known models, namely the drug release model (dissolution model) with a drug transport model (compartmental absorption and transit (CAT) model) to predict the release, distribution, absorption and elimination of an oral drug through the gastrointestinal (GI) tract of the human body. In the CAT model, the GI tract is envisioned as a series of compartments, where each compartment is assumed to be a continuous stirred tank reactor (CSTR). We coupled the drug release model in the form of partial differential equations (PDE's) with the CAT model in the form of ordinary differential equations (ODE's). The developed model can also be used to design the drug tablet for target pharmacokinetic characteristics. The advantage of the suggested approach is that it includes the mechanism of drug release and also the properties of the polymer carrier into the model. The model is flexible and can be adapted based on the requirements of the clients. Through this model, we were also able to avoid depending on commercially available software which are very expensive. In the drug discovery and development process, the tablet formulation (oral drug delivery) is an important step. The tablet consists of active pharmaceutical ingredient (API), excipients and polymer. A controlled release of drug from this tablet usually involves swelling of the polymer, forming a gel layer and diffusion of drug through the gel layer into the body. The polymer is mainly responsible for controlling the release rate (of the drug from the tablet), which would lead to a desired therapeutic effect on the body. In our research, we also developed a molecular design strategy for generating molecular structures of polymer candidates with desired properties. Structure-property relationships and group contributions are used to estimate the polymer properties based on the polymer molecular structure, along with a computer aided technique to generate molecular structures of polymers having desired properties. In greater detail, we utilized group contribution models to estimate several desired polymer properties such as grass transition temperature (Tg), density (ρ) and linear expansion coefficient (α). We subsequently solved an optimization model, which generated molecular structures of polymers with desired property values. Some examples of new polymer repeat units are - [CONHCH₂ - CH₂NHCO]n -, - [CHOH - COO]n -. These repeat-units could potentially lead to novel polymers with interesting characteristics; a polymer chemist could further investigate these. We recognize the need to develop group contribution models for other polymer properties such as porosity of the polymer and diffusion coefficients of water and drug in the polymer, which are not currently available in literature. The geometric characteristics and the make-up of the drug tablet have a large impact on the drug release profile in the GI tract. We are exploring the concept of tablet customization, namely designing the dosage form of the tablet based on a desired release profile. We proposed tablet configurations which could lead to desired release profiles such as constant or zero-order release, Gaussian release and pulsatile release. We expect our work to aid in the product innovation process.<br>Ph. D.
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GUPTA, PREETI. "HYDROGEL BASED WOUND DRESSING MATERIAL." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18806.

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Weak mechanical strength of hydrogels in wet condition limits their use for load bearing applications. Their mechanical strength can be raised by grafting them over some support or by converting them into nanofibrous form. Present thesis is focused on the preparation of poly (acrylamide-co-acrylic acid) hydrogel grafted over cotton fabric using two different cross-linkers i.e. PEG and MBAAm for making medicated dressing and nanofibers of hydrogel of poly (acrylamide-co-acrylic acid). FTIR was used to confirm the insertion of cross-links into the polymer chains. Grafting of uniform hydrogel layer on cotton surface and formation of hydrogel nanofibers were confirmed by using SEM. The average fibre diameter was found to be 275±94.5 nm. Swelling of composite prepared using PEG followed first-order kinetic model at acidic and neutral pH whereas second-order kinetic model at pH 8.5 while that prepared using MBAAm followed second-order kinetic equation at all the pHs studied. The kinetics of swelling was also governed by Peppas model at all pHs. Release of drug from both the composites was studied in phosphate buffers having pH 5.5,7 and 8.5 at 37±0.1°C and observed that it was fastest in phosphate buffer having pH 7. On fitting drug release data into different models, it was observed that drug release was diffusion controlled and followed Fickian diffusion mechanism in case of composite prepared by using PEG as cross-linker whereas it was controlled by diffusion as well as chain relaxation in case of composite prepared by using MBAAm. Mechanical testing using Universal Testing Machine supported a higher mechanical strength of the hydrogel composite as compared to its film. Swelling behaviour of Nanofibrous mats was found to be highest at neutral pH and it followed second order kinetics at all pHs. The drug release kinetics was further evaluated and found that it took place by Fickian diffusion (n < 0.5) and followed second order release kinetics. Antimicrobial tests were performed to show the effectiveness of drug loaded within the hydrogel samples.
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Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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ANGELLOTTI, Giuseppe. "Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e antiossidanti. Utilizzo in chirurgia orale." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580944.

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La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carcinoma orale a cellule squamose (OSCC) che è tra i più aggressivi tumori del collo e della testa, caratterizzato dal più basso tasso di sopravvivenza a 5 anni. Va inoltre presa in considerazione la posizione anatomica del cavo orale che, essendo facilmente accessibile dall’esterno, è suscettibile ad infezioni batteriche che possono compromettere uno stato di salute già debilitato e/o peggiorare la condizione clinica delle problematiche sopra citate. Nel trattamento delle affezioni del cavo orale è di fondamentale importanza ottenere una rapida remissione della sintomatologia, favorendo la rigenerazione del tessuto leso e prevenendo le complicazioni infettive mediante una terapia mirata, efficace e localizzata. Tuttavia, le strategie terapeutiche attualmente in uso sono spesso invasive e in alcuni casi meramente palliative (es. rimozione chirurgica del tessuto necrotico anche osseo), o spesso la necessità di ricorrere a terapie farmacologiche aggressive non scevre da effetti avversi anche gravi può contribuire ad un peggioramento di una condizione patologica preesistente. Per superare gli inconvenienti dati dai trattamenti convenzionali, recentemente è stato proposto l’utilizzo di sostanze naturali di origine vegetale aventi comprovate proprietà terapeutiche benefiche (es. antiossidanti, antinfiammatorie, antitumorali, antibatteriche), capacità di stimolazione dei processi di rigenerazione tissutale, e soprattutto, effetti collaterali trascurabili. Tra le varie classi di composti naturali che potrebbero rispondere a tali requisiti, i polifenoli sono quella di maggiore interesse scientifico. Si tratta di un gruppo di molecole molto eterogeneo accomunato chimicamente dalla presenza di uno o più gruppi fenolici. Sebbene i polifenoli si trovino in molteplici fonti alimentari e le loro svariate proprietà benefiche siano ben note, il loro utilizzo in ambito clinico è ancora una sfida aperta a causa delle loro caratteristiche chimico-fisiche e farmacocinetiche generalmente sfavorevoli, quali instabilità chimica e fisica, quando soggette ai fenomeni ambientali come le radiazioni ultraviolette, temperatura elevata o pH fortemente acido o alcalino, scarsa solubilità in ambiente acquoso, elevata suscettibilità al metabolismo epatico e, quindi, bassa biodisponibilità a seguito di somministrazione orale. Per superare tali limiti e rendere somministrabili ed efficaci i polifenoli è quindi auspicabile la realizzazione di drug delivery platform o carrier in grado di incorporare efficacemente tali attivi, preservarne l’integrità strutturale e funzionale e modularne il rilascio al sito target. Inoltre, per promuovere la guarigione dagli stati patologici sopra elencati, può risultare utile la co-somministrazione di polifenoli ed antibatterici tra quelli già utilizzati in chirurgia orale. Tenendo in considerazione queste premesse nel presente lavoro di dottorato sono stati realizzati innovativi sistemi di veicolazione capaci di incorporare polifenoli quali Curcumina, Quercetina e Resveratrolo da soli o in co-somministrazione con antibiotici quali il Metronidazolo e la Ciprofloxacina, per il trattamento localizzato delle suddette patologie associate al cavo orale. Una strategia per la veicolazione dei polifenoli consiste nella loro incapsulazione in sistemi micro e nanoparticellari. A tal fine sono state realizzate microparticelle polimeriche contenenti Resveratrolo con la tecnica dello Spray Drying, ottimizzando accuratamente i parametri operativi al fine di ottenere particelle sferiche, di dimensione omogenea ed uniformi in termini di contenuto in attivo. Tale strategia ha consentito la completa amorfizzazione del Resveratrolo, incrementandone notevolmente la solubilità in ambiente acquoso, e promuoverne la permeabilità attraverso la mucosa sublinguale. I Carrier Lipidici Nanostrutturati (NLC), costituiti da particelle di dimensioni nanometriche, si sono rivelati un altro sistema di veicolazione dei polifenoli particolarmente promettente, proprio grazie alla loro natura lipidica che ben si è adattata alle caratteristiche chimico-fisiche dei polifenoli. Un’attenta selezione dei componenti lipidici e del bilanciamento degli stessi in relazione al tipo ed alla quantità di polifenolo da incapsulare, ha consentito la preparazione di miscele omogenee, aventi temperatura di rammollimento opportuna (stabilità, storage e maneggevolezza) ma soprattutto contenenti il polifenolo nella sua forma amorfa. Sono stati pertanto preparati e caratterizzati diversi sistemi NLC contenenti rispettivamente Curcumina, Quercetina e Resveratrolo. L’ottimizzazione della tecnica di preparazione top-down ad alta energia caratterizzata da omogeneizzazione seguita da sonicazione ad alte frequenze, ha portato alla produzione di nanoparticelle riproducibili ed omogenee (<500 nm, PDI < 0.600), caratterizzate da un’elevata efficienza di incapsulazione (>95%) ed in grado di controllare il rilascio degli attivi secondo cinetiche ben definite. Per consentire la co-somministrazione dei polifenoli (lipofili) con gli antibiotici precedentemente menzionati (idrofili), sono stati ulteriormente realizzati dei sistemi nanocompositi sotto forma di spugne bioerodibili, costituite da una matrice polimerica biocompatibile e bioerodibile (a base di Chitosano o Acido Ialuronico, e PVP K90) all’interno della quale sono state intrappolate le nanoparticelle lipidiche. I nanocompositi, essendo formulazioni polverulente, hanno mostrato diverse caratteristiche favorevoli, tra cui: omogeneità, elevata porosità, capacità di promuovere l’accumulo degli attivi nei tessuti del cavo orale ed elevata stabilità nel tempo, preservando così i polifenoli dalla degradazione. Inoltre, la “trasformazione” delle dispersioni acquose di NLC in un sistema anidro porta all’ottenimento di una polvere secca estremamente semplice da manipolare ed applicare, consentendo di dosare i principi attivi in modo accurato e riproducibile. Studi in vitro, hanno dimostrato, inoltre, la citocompatibilità delle spugne bioerodibili a base di Curcumina, coì come la citocompatibilità delle NLC cariche di Resveratrolo con i fibroblasti murini, mentre le spugne a base di Quercetina e Ciprofloxacina hanno evidenziato proprietà antibatteriche e antibiofilm nei confronti dello Staphilococcus aureus superiori all’antibiotico in forma libera.Parallelamente, è stata impiegata la tecnica della stampa 3D per la realizzazione di scaffold polimerici carichi sia di Curcumina, in cui l’aggiunta di beta-tricalcio fosfato (bioceramica), è stata in grado di influenzare positivamente le caratteristiche dello scaffold, aumentandone la porosità e promuovendo la stabilità della Curcumina in fase di preparazione. In conclusione, il lavoro di ricerca svolto ha portato allo sviluppo tecnologico, da una parte, di valide ed efficienti delivery platform nano- e micrometriche per la veicolazione dei polifenoli e, dall’altra, alla produzione di sistemi di drug delivery macroscopici (nanocompositi e scaffold) potenzialmente utili per il trattamento delle patologie del cavo orale.
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Books on the topic "Kinetics For Drug Release"

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Nagar, Swati, Upendra A. Argikar, and Donald Tweedie, eds. Enzyme Kinetics in Drug Metabolism. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1554-6.

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Nagar, Swati, Upendra A. Argikar, and Donald J. Tweedie, eds. Enzyme Kinetics in Drug Metabolism. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-758-7.

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Akash, Muhammad Sajid Hamid, and Kanwal Rehman, eds. Drug Stability and Chemical Kinetics. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6426-0.

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Keserü, György M., and David C. Swinney, eds. Thermodynamics and Kinetics of Drug Binding. Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527673025.

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Nora, Chiang C., Lee Charles C, and National Institute on Drug Abuse., eds. Prenatal drug exposure: Kinetics and dynamics. U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1985.

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Gerhard, Levy, and Esteve Foundation, eds. Kinetics of drug action in disease states. Prous Science, 2002.

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1944-, Rubinstein M. H., ed. Pharmaceutical technology--controlled drug release. Ellis Horwood, 1987.

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1957-, Rathbone Michael J., Hadgraft Jonathan 1950-, and Roberts Michael S. 1949-, eds. Modified-release drug delivery technology. Marcel Dekker, 2003.

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D, Ingram, and Jackson Stephen, eds. Human drug kinetics: A course of simulated experiments. IRL Press, 1989.

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Wilson, Clive G., and Patrick J. Crowley, eds. Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1.

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Book chapters on the topic "Kinetics For Drug Release"

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Colombo, Paolo, Gaia Colombo, and Christine Cahyadi. "Geometric Release Systems: Principles, Release Mechanisms, Kinetics, Polymer Science, and Release-Modifying Material." In Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_11.

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Lee, Ping I. "Kinetics of Drug Release from Glassy Polymers: Effect of Initially Nonuniform Drug Distribution." In Polymeric Materials in Medication. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2245-8_7.

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Grabow, N., S. Siewert, K. Sternberg, H. Martin, and K. P. Schmitz. "Simulation of Drug Release for the Development of Drug-Eluting Stents - Influence of Design and Manufacturing Parameters on Drug Release Kinetics." In IFMBE Proceedings. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03887-7_40.

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Delfour, Michel C., and André Garon. "Quadratic ODE and PDE Models of Drug Release Kinetics from Biodegradable Polymers." In IFIP Advances in Information and Communication Technology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36062-6_2.

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Sukhodub, L. B., M. O. Kumeda, and L. F. Sukhodub. "Influence of MW Irradiation on the Hydroxyapatite/Chitosan Composite Structure and Drug Release Kinetics." In IFMBE Proceedings. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31866-6_64.

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Lee, Ping I. "Interpretation of Drug-Release Kinetics from Hydrogel Matrices in Terms of Time-Dependent Diffusion Coefficients." In ACS Symposium Series. American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0348.ch005.

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Mohd Sabee, M. M. S., and Z. A. Abdul Hamid. "Comparison of Gentamicin and Dexamethasone Release Kinetics from Poly(Lactic Acid) (PLA) Microspheres for Drug Delivery Systems." In Springer Proceedings in Materials. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2015-0_11.

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Caldwell, J., and S. A. Hotchkiss. "In vivo Dissolution and Absorption Kinetics of Sustained-Release Theophylline, Studied with Stable Isotope Methodology." In Drug Absorption at Different Regions of the Human Gastro-Intestinal Tract: Methods of Investigation and Results / Arzneimittelabsorption aus verschiedenen Bereichen des Gastrointestinaltraktes beim Menschen: Untersuchungsmethoden und Ergebnisse. Vieweg+Teubner Verlag, 1987. http://dx.doi.org/10.1007/978-3-322-91091-2_4.

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Sirois, P., M. Harczy, J. Maclouf, P. Pradelles, P. Braquet, and P. Borgeat. "Lipid Mediators in Lung Anaphylaxis: Kinetics of Their Release and Modulation by Selected Drugs." In Lipid Mediators in the Immunology of Shock. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0919-2_20.

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Woodcock, B. G., G. Menke, A. Fischer, H. Köhne, and N. Rietbrock. "Drug Input Rate from the GI-Tract. Michaelis-Menten Kinetics and the Bioavailability of Slow-Release Verapamil and Nifedipine." In Drug Absorption at Different Regions of the Human Gastro-Intestinal Tract: Methods of Investigation and Results / Arzneimittelabsorption aus verschiedenen Bereichen des Gastrointestinaltraktes beim Menschen: Untersuchungsmethoden und Ergebnisse. Vieweg+Teubner Verlag, 1987. http://dx.doi.org/10.1007/978-3-322-91091-2_16.

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Conference papers on the topic "Kinetics For Drug Release"

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Keo, Van Dong, Xuan Tran Hiep, Quoc Nguyen Banh, Tran Anh Son, and Duong Huyen Lynh. "Determination of Geometrical Parameters to Balance the Pressure Drop of Channels on a Microfluidic Chip." In 2024 International Conference on Machining, Materials and Mechanical Technologies. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-me24oh.

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In the past few years, micro-droplets have been widely used in diverse fields of biological and chemical research, spanning from drug delivery and material synthesis to point-of-care diagnostics, digital PCR, and single-cell analysis. Droplet-based microfluidics offers a powerful platform for conducting complex experiments, screening processes, and analyses with enhanced precision, efficiency, and versatility. While creating droplets with uniform sizes is a common objective of microfluidics, it is not limited to producing droplets of a single size per chip. Creating microdroplets with different sizes on a microfluidic chip holds significant importance in various applications. This can provide flexibility in controlling chemical processes, biological reactions, or product quality. By controlling the size of the microdroplets, researchers can precisely regulate the release kinetics of the encapsulated substances, leading to improved therapeutic outcomes and reduced side effects for patients. In chemical analysis, microfluidic platforms can produce microdroplets of different sizes to enable high-throughput screening of chemical reactions or biological assays. By manipulating the droplet size, researchers can enhance reaction efficiency, increase sample throughput, and reduce reagent consumption, making the analysis process more cost-effective and time-efficient. To create microdroplets with different sizes on a microfluidic chip, adjusting process parameters such as pressure, flow rate, and channel design is an approach. In this research, geometrical parameters of the channel such as shape, size, and length are calculated to ensure the pressure drop from the inlet to the creation point droplets of each branch is the same, ensuring the stable operation of the system. The input solution in the research is glucose, which fully exhibits the behavior of a non-Newtonian liquid under defined conditions. The power law viscosity model is used to describe the rheological behavior of glucose liquids.
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Swaroop, K., and H. M. Somashekarappa. "Swelling characteristics and drug release kinetics of Ag/PVA hydrogel nanocomposites." In DAE SOLID STATE PHYSICS SYMPOSIUM 2016. Author(s), 2017. http://dx.doi.org/10.1063/1.4980807.

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Wang Hong and Hongyu Chen. "Study of the drug release kinetics in nanoscale micelle to micelle system." In 2010 IEEE 3rd International Nanoelectronics Conference (INEC). IEEE, 2010. http://dx.doi.org/10.1109/inec.2010.5424875.

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Shaikenov, Roman, Vladislava Klimshina, Yuliya Generalova, et al. "Electrospun Hyaluronan-Based Nanofibers with Mangiferin: Preparation, Morphology, and Drug Release Kinetics." In IOCBE 2024. MDPI, 2024. http://dx.doi.org/10.3390/engproc2024081002.

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Berchane, Nader S., Kenneth H. Carson, Allison C. Rice-Ficht, and Malcolm J. Andrews. "Investigation of Drug Release From Biodegradable PLG Microspheres: Experiment and Theory." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176030.

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Piroxicam containing PLG microspheres having different size distributions were fabricated, and in vitro release kinetics were determined for each preparation. Based on the experimental results, a suitable mathematical theory has been developed that incorporates the effect of microsphere size distribution and polymer degradation on drug release. We show from in vitro release experiments that microsphere size has a significant effect on drug release rate. The initial release rate decreased with an increase in microsphere size. In addition, the release profile changed from first order to concave-upward (sigmoidal) as the system size was increased. The mathematical model gave a good fit to the experimental release data.
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Grattoni, Alessandro, Xuewu Liu, Zongxing Wang, Jaskaran Gill, Arturas Ziemys, and Mauro Ferrari. "Electrokinetic Transport of Molecules Through Nanochanneled Membranes." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13236.

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Our research group was the first one to microfabricate and demonstrate nano-channels in silicon membranes (1, 2). We employed nano-channeled chips to provide immuno-isolation for cell transplantation towards the treatment of diabetes (3), for biomolecular separation (4), and for the controlled passive and active release of drug molecules from implanted capsules (5). We showed that the constraints placed upon molecular agitation in nano-channels affected their concentration-driven transport kinetics (6, 7). A zero-order passive release of biological molecules was achieved, by the rational tailoring of nano-channels dimensions. This achievement allowed releasing of a constant amount of drugs over a long period of time. However, the development and optimization of many drug therapies require long-term drug delivery with controlled but variable dosage using miniaturized systems (8). Moreover, application such as drug release from implanted devices requires tight operational control, of regulatory agency caliber. We have engaged in the development and characterization of elecroosmotic nano-channels membranes, and present our results in this communication. These include the influence of the drug release rate on nanochannel size, membrane configuration, and applied voltage.
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Perkins, Jessica L., Salil Desai, Benjamin Harrison, and Jagannathan Sankar. "Understanding Release Kinetics of Calcium Alginate Microcapsules Using Drop on Demand Inkjet Printing." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12819.

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This paper investigates the use of calcium alginate microcapsules to transport biomaterials for drug delivery. Rhodamine 6G dye was encapsulated in microcapsules for different formulations of the hydrogels using drop-on-demand printing. An experimental design was constructed to compare the effect of different concentrations of calcium chloride (M) and sodium alginate (% w/v) solutions in addition to the microcapsule diameter on the release kinetics profiles of the microcapsules. The results of these findings provide a basis to identify favorable sizes of microcapsules and concentrations of sodium alginate and calcium chloride solutions for controlled release behavior of microcapsules.
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ginistrelli, Edoardo, Cecilia Bertiond, Davide Janner, et al. "Hollow resorbable fiber for combined light and drug delivery: fiber development and analysis of release kinetics." In Novel Biophotonics Techniques and Applications IV, edited by Arjen Amelink and I. Alex Vitkin. SPIE, 2017. http://dx.doi.org/10.1117/12.2284313.

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Ulfa, Maria, Rufaida M. Hasanah, and Didik Prasetyoko. "Release kinetics performance of ibuprofen molecule from ordered mesoporous carbon with deferent concentration of drug loading." In 2ND INTERNATIONAL CONFERENCE ON CHEMISTRY, CHEMICAL PROCESS AND ENGINEERING (IC3PE). Author(s), 2018. http://dx.doi.org/10.1063/1.5064961.

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Markovic, Maja, Vesna Panic, Julijana Tadic, and Rada Pjanovic. "EFFECT OF CROSSLINKER AMOUNT ON HYBRID HYDROGELS SWELLING AND DRUG RELEASE." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.125m.

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Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficient therapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly water- soluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based on poly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pH sensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAA can only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous research was directed towards overcoming this limitation: PMAA was modified with amphiphilic protein – casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study is focused on investigation how variation of amount of one of the most important hydrogels network parameter such as crosslinker affect PMAC swelling properties and caffeine release. The group of hybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%, 1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels and caffeine release was investigated in two environments which simulated human stomach and intestines. Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved and that its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can be easily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential for targeted delivery of poorly water-soluble active substances.
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Reports on the topic "Kinetics For Drug Release"

1

Noel, Erika, Giulia Mattana, and Anthony McGoron. A Comparative Analysis of Nanoparticle Sizing Techniques for Enhanced Drug Delivery Applications. Florida International University, 2025. https://doi.org/10.25148/fiuurj.3.1.5.

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Nanoparticle-based drug delivery systems hold promise for improving therapeutic efficacy and targeting precision. However, a critical challenge in their development is ensuring size stability, as particle size directly influences biodistribution, cellular uptake, and drug release profiles. This study establishes a streamlined methodology to assess nanoparticle size consistency by comparing three widely used characterization techniques: Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), and Nanoparticle Tracking Analysis (NTA). Two types of nanoparticles were analyzed: 100 nm diameter Gold Nanoparticles (GNP) suspended in a stabilized sodium citrate buffer and Mesoporous Silica Nanoparticles (MSN), both diluted in deionized water. DLS provides particle size distribution based on light scattering intensity, TEM offers high-resolution imaging for precise structural measurements, and NTA tracks individual particles to assess size and concentration through Brownian motion. Our findings highlight the complementary strengths of each technique, with NTA emerging as the most versatile method for rapid size assessment due to its broad size range and concentration capabilities. This research establishes a reliable, reproducible protocol for nanoparticle sizing, which can be integrated into computational models to predict drug release kinetics. These results contribute to the optimization of nanoparticle formulations for enhanced drug delivery applications.
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Chutimaworapan, Suchada, Chaiyo Chaichantippayuth, and Areerat Laopaksa. Formulation of pharmaceutical products of Garcinia mangostana Linn. extracts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.32.

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Part I: The purpose of the investigation was to develop the extraction process that was simple, practical and giving high yield. The maceration of dried powder of Garcinia mangostana fruit husk with ethyl acetate gave yellow crystalline powder of mangostin. The yield was calculated as 7.47%. The identification of the Garcinia mangostanahusk extract was carried out by thin-layer chromatography (TLC) and differential scanning calorimetry. The TLC of mangostin was done by using the alumina sheet and ethyl acetate: hexane (3:1) as mobile phase. The Rf value as compared with standard mangostin was 0.60. The DSC thermogram showed the board melting range of the crude extract at 165.04-166.80 °C. The quantitative analyses of mangostin were developed using the high performance liquid chromatography (HPLC) and ultraviolet (UV) spectrophotometry. The HPLC system using methanol: water (87:13) as mobile phase, clotrimazole as internal standard and using UV detector at 243 nm. The UV spectrophotometric method was carried out using the UV spectrophotometer at 243 nm. The validation of both systems gave high specificity, linearity, accuracy and precision. The solubility study of mangostin showed the low water insolubility. The water solubility was improving with increasing ethanol content. The in vitro microbiological activity of mangostin to Staphylococcus aureus ATCC 25923 and Streptococcus mutans ATCC KPSK2 was studied. The minimum inhibitory concentrations of the extract were 3 µg/ml and 1.5 µg/ml, respectively. The minimum bactericidal concentrations of the extract was 4 µg/ml and 3 µg/ml, respectively.Part II: The purpose of this study was to develop fast dissolving oral strips containing Garcinia mangostana husk extract. The films consisted of low viscosity hydrophilic polymers such as hydroxypropyl methylcellulose and hydroxypropylcellulose, acesulfame potassium as sweetener, and menthol and eucalyptus oil as flavoring agents. The physical and mechanical properties and dissolution time of film bases were compared with commercial product strips A. From the dissolution time data, it was found that the film prepared from mixed polymer between HPMC 3 cps and HPC LV at ratios 2:1, 3:1, 4:1 and 5:1 were not significantly different from commercial product strips A (p&gt;0.05). The films containing extract were light yellow and had porous surface based on observation from scanning electron microscopy. The dissolution profiles of all formulations showed the rapid release more than 80 percent of mangostin from films within 3-7 minutes and the fastest release was from formulation of HPMC 3 cps and HPC LV at ratio 5:1. Differential scanning calorimetry results exhibited that the Garcinia mangostana extract and additives were not in crystalline form in the films. The fast dissolving oral strips containing Garcinia mangostana husk extract showed in vitro antimicrobial activity against oro-dental bacteria, namely, Staphylococcus aureus aTCC 25923 and Streptococcus mutans ATCC KPSK2. Unter strese conditions at 40 degree Celcius and 75 percent relative humidity, the strips showed a good stability.The purpose of the study was to develop monoglyceride-based drug delivery systems containing Garcinia Mangostana extract. The system is based on the ability of mixtures of monoglyceride (dlyceryl monooleate) and triglycerides to form liquid crystals upon contact with water. The drug delivery systems can be administered by syringe and transformed into high-viscous liquid crystalline phases at the injection site. Ternary phase diagrams were constructed from various triglycerides: sesame oil, soybean oil and olive oil. In this study, monoglyceride-based drug delivery systems were prepared in the ratio of triglycerides: monoglyceride: water as 8: 62: 30 and 12: 58: 30. These systems could sustain release of Garcinia Mangostana husk extract over a period of 48 hr and followed squared root of time kinetics during the initial 24 hr of the release phase, indicating that the rate of release was diffusion-controlled. The system containing sesame oil showed the highest drug release. The increasing triglyceride content did not affect the release profiles. Differential scanning calorimetry results demonstrated that Garcinia Mangostana husk extract could be incorporated into drug delivery systems without causing phase transition. In the in vitro test, monoglyceride-based drug delivery systems containing Garcinia mangostana husk extract did not show the antimicrobial activity probably due to the high lipophilicity of the extract therefore it did not diffuse into the medium. Additionally, the drug delivery systems containing Garcinia mangostana husk extract showed good stability under the stress condition.
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Stanton, Patric K. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada607813.

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Garrido Sanabria, Emilio R. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada608027.

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Garrido-Sanabria, Emilio. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada610543.

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Stanton, Patric K. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580461.

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Garrido, Emilio R. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580462.

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Stanton, Patric. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581556.

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Quanci, J. Tritium breeding and release-rate kinetics from neutron-irradiated lithium oxide. Office of Scientific and Technical Information (OSTI), 1989. http://dx.doi.org/10.2172/5935493.

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Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, 2021. http://dx.doi.org/10.25148/mmeurs.009774.

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Cervical cancer is one of the most common causes of cancer death for women in the United States. The current treatment with chemotherapy drugs has significant side effects and may cause harm to healthy cells rather than cancer cells. In order to combat the potential side effects, nanoparticles composed of mesoporous silica were created to house the chemotherapy drug doxorubicin (DOX). The silica network contains the drug, and a pH study was conducted to determine the conditions for the nanoparticle to disperse the drug. The introduction of disulfide bonds within the nanoparticle created a framework to efficiently release 97% of DOX in acidic environments and 40% release in neutral environments. The denotation of acidic versus neutral environments was important as cancer cells are typically acidic. The chemistry was proved with the incubation of the loaded nanoparticle into HeLa cells for a cytotoxicity report and confocal imaging. The use of the framework for the anticancer drug was shown to be effective for the killing of cancerous cells.
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