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Dissertations / Theses on the topic 'Kinetics For Drug Release'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Jones, Stephen Joseph. "Investigating nonlinear enzyme kinetics as an internal control system for nanoreactor drug release." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22207/.

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The improper administration of therapeutic compounds is not only financially inefficient, but, there exists a very real risk of harmful, or potentially life-threatening effects. To gain control, nano-drug delivery systems provide a discernible option for temporal and spatial regulation of drug bioavailability within the body. In current regimes, temporal control is realised through gradual release over an extended period of time, or triggered release in response to a change in the physiochemical environment. Of course, when considering the design of an ideal drug delivery system, we think of a

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2

He, Xingyu. "Long-term Light-activated Drug Delivery Systems." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752062550859.

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3

Fugit, Kyle Daniel. "QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/37.

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Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal rel

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4

Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gast

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5

Modi, Sweta. "The Critical Role of Mechanism-Based Models for Understanding and Predicting Liposomal Drug Loading, Binding and Release Kinetics." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/19.

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Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment. Membrane binding of the drug affects both dru

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6

Cui, Yong. "Enhanced Release of Lidocaine From Supersaturated Solutions of Lidocaine In A Pressure Sensitive Adhesive." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054210962.

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7

Pavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.

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One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions, fits into the overall goal and complements the product development process. Our research focuses on the early preclinical stage of the drug development process

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8

GUPTA, PREETI. "HYDROGEL BASED WOUND DRESSING MATERIAL." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18806.

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Weak mechanical strength of hydrogels in wet condition limits their use for load bearing applications. Their mechanical strength can be raised by grafting them over some support or by converting them into nanofibrous form. Present thesis is focused on the preparation of poly (acrylamide-co-acrylic acid) hydrogel grafted over cotton fabric using two different cross-linkers i.e. PEG and MBAAm for making medicated dressing and nanofibers of hydrogel of poly (acrylamide-co-acrylic acid). FTIR was used to confirm the insertion of cross-links into the polymer chains. Grafting of uniform hydro

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9

Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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10

ANGELLOTTI, Giuseppe. "Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e antiossidanti. Utilizzo in chirurgia orale." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580944.

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La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carc

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11

Knaack, Sven. "Entwicklung und Charakterisierung von Scaffolds auf Basis von mineralisiertem Kollagen zur gezielten Wirkstofffreisetzung für die Knochengewebe-Regeneration." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-188547.

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Beim Tissue Engineering ist die Vaskularisierung von größeren Zell-Matrix-Konstrukten nach Implantation bis heute ein großes Problem. Durch das initiale Fehlen eines mikrovaskulären Netzwerkes kommt es zu einem raschen Zellsterben im Scaffold. Aufgrund dessen war das Ziel dieser Arbeit, im Sinne des in situ-Tissue Engineering ein Scaffold auf Basis von mineralisiertem Kollagen zu entwickeln, welches mit dem angiogenen Wachstumsfaktor VEGF funktionalisiert wird, um den Prozess der Vaskularisierung – die Einsprossung von Blutgefäßen – zu fördern und gleichzeitig durch Chemoattraktion in vivo Z

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12

Lee, Wang Wang. "Factors affecting drug release and absorption from a novel oral delayed release drug delivery system." Thesis, Durham University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269886.

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13

Thapa, Pariksha. "Kinetics of Microvesicle Particle Release in Keratinocytes." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1566504910360327.

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14

Pygall, Samuel R. "Critical processes in drug release from HPMC controlled release matrices." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/14128/.

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This study has investigated the drug release mechanisms from hydroxypropyl methylcellulose (HPMC) hydrophilic matrices. A hypothesis was developed from interpretation of a previous study that drug surface activity has an influence on drug liberation. The validity of the hypothesis was tested by studying the interactions between HPMC and the two non-steroidal anti-inflammatory drugs diclofenac Na and meclofenamate Na, using tensiometry, rheology, NMR, neutron scattering and turbimetry. Meclofenamate Na was found to interact with HPMC, resulting in detectable changes in drug diffusion coefficien

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15

Steiner, Katrin [Verfasser]. "The influence of drug core properties on drug release from extended release reservoir pellets / Katrin Steiner." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025239733/34.

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16

Fitzpatrick, John J. "Drug release from methotrexate polumer conjugates." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259695.

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17

Stenton, Benjamin James. "Metal mediated mechanisms of drug release." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284402.

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In this thesis will be described research towards the development of bioorthogonal bond-cleavage reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or "decaging" reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the incorporation of a protein modification handle which allowed an amine-bearing drug to be covalently ligated to a protein by a palladium-cleavable linker. This chemistry was demonstrated by the conjugation of the antica

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18

Sheldon, Jonathon. "Light Controlled Drug Activation and Release." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4055.

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Cancer constitutes a terrible burden on modern society. In the United States there are an estimated 1,658,370 new cancer diagnoses resulting in 589,430 deaths in 2015 alone.[1] An estimated 41,170 of these cases will be diagnosed right here in Virginia. With new cancer patients comes the expanding demand for new treatments. As we all know, many modern chemotherapeutics cause adverse reactions to patients. This is because the toxic nature of these therapies often affects normal tissue alongside the tumors that are infesting the body. Therefore, researching novel ways to make chemotherapeutics s

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19

Gao, Xiang. "Kinetics of drug disposition and effects /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942739808919.

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20

Ali, Mohamed A. "Preparation, kinetics and mechanism of release of carbofuran lignin-based controlled release formulations." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289103.

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21

Sinha, Piyush M. "Nanoengineered implantable devices for controlled drug delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1115138930.

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22

Milroy, Georgina Emily. "Degradation and drug release behaviour of polyglycolide." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415273.

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23

Shehab, M. A. "Drug release from liquid filled capsule formulations." Thesis, De Montfort University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373432.

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24

Ambardekar, Rohan. "Controlled drug release from oriented biodegradable polymers." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14867.

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This research is the first systematic investigation of solid-state orientation as a novel method for controlling drug release from biodegradable polymers. The effect of various degrees of polymer orientation was studied in oriented Poly (L-lactic acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug release was studied from oriented PLA rods containing paracetamol. The films oriented to 2X uniaxial constant width (UCW) or 2X2Y biaxial draw ratio showed retardation of drug release, when their nematic structure was stabilised by the presence

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25

Sevim, Kevser. "Modelling of drug release from biodegradable polymers." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40864.

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Biodegradable polymers have highly desirable applications in the field of biomedical engineering, such as coronary stents, tissue engineering scaffolds and controlled release formulations. All these applications are primarily rely on the fact that the polymers ultimately disappear after providing a desired function. In this respect, the mechanism of their degradation and erosion in aqueous media has attracted great attention. There are several factors affecting the rate of degradation such as composition, molecular weight, crystallinity and sample size. Experimental investigations showed that

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26

Robinson, Susan. "Poly(α-hydroxyacids) : degradation and drug release". Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624353.

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27

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid

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28

Podaru, George. "Exploring controlled drug release from magneto liposomes." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35544.

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Doctor of Philosophy<br>Department of Chemistry<br>Viktor Chikan<br>This thesis focuses on exploring fast and controlled drug release from several liposomal drug delivery systems including its underlying mechanics. In addition, the construction of a pulsed high-voltage rotating electromagnet is demonstrated based on a nested Helmholtz coil design. Although lots of different drug delivery mechanisms can be used, fast drug delivery is very important to utilize drug molecules that are short-lived under physiological conditions. Techniques that can release model molecules under physiological condi

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29

Chia, Leonard Sze Onn. "Investigating controlled release pulmonary drug delivery systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273209.

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The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved by reducing the number of times drugs need to be administered. In this study, two controlled pulmonary drug delivery systems for drugs of different solubilities were investigated and they were characterised for their viability as effective controlled release pulmonary drug delivery systems, particula

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30

Talbert, Ann Marie. "Drug protein binding kinetics from chromatographic profiles." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406921.

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31

Ghori, Muhammad U. "Release kinetics, compaction and electrostatic properties of hydrophilic matrices." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/24269/.

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This thesis illustrates the behaviour of cellulose ethers during powder processing, compaction and drug release, as these are frequently employed in the fabrication of compressed hydrophilic matrices. The handling operations can give rise to the electrification of powder particles, which can affect the end product‘s quality. Controlling the parameters which can dictate the quality of compressed matrices is an ambition inherent in the development of pharmaceutical formulations. Thus, the aims and objectives of this thesis were to firstly study the electrostatic, surface adhesion, dissolution an

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32

Awosanya, Ibikunle. "The kinetics of ion release by glass-ionomer cements." Thesis, University of Greenwich, 2008. http://gala.gre.ac.uk/6103/.

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Ten brands of GIC were used in this study: four commercial conventional GICs, one in-house conventional GIC made from G338 glass powder, one commercial glass-ionomer bone cement and four in-house novel aluminium free Fe2O3 based GICs. Cylindrical specimens of GICs were prepared in stainless steel moulds to form 6 mm height x 4 mm diameter cylinders which were then placed in a 37°C oven for one hour to cure and harden. These were then immersed in 5 ml aliquots of de-ionised water and 20mM lactic acid for storage periods of 14, 28 and 84 days, 8 weeks and 21 months. The leachate was collected da

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33

Leo, Tiffany. "Uptake and Release Kinetics of Sulfolane by Cattail Plants." DigitalCommons@USU, 2008. https://digitalcommons.usu.edu/etd/47.

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Sulfolane (tetrahydrothiophene 1,1-dioxide, C4H8O2S) is a highly water-soluble, non-ionizable, organic compound used along with diisopropanolamine in the SulfinolTM process to remove hydrogen sulfide from natural gas. Sulfolane has been identified in wetland vegetation near a sour gas processing facility in Alberta, Canada, and extensive uptake of sulfolane by cattails has also been demonstrated in a laboratory environment. Consequently, it has been suggested that plants could play an important role in the natural attenuation of sulfolane in contaminated wetlands. This assumes that the sulfola

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34

Chaerunisaa, Anis Yohana [Verfasser]. "Release adjustment of drug combinations with different drug solubility / Anis Yohana Chaerunisaa." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1048327388/34.

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35

Pavlakis, Evangelos K. "Novel drug coatings of pharmaceutical suspensions to control drug release of ibuprofen." Thesis, University of Huddersfield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417301.

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36

Wang, Juan. "Characterization of microsphere drug delivery systems during encapsulation and initial drug release /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488202678776876.

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37

Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.

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38

Gilligan, Claire A. "Controlled release polymeric films and pellets." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336028.

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39

Bramer, Tobias. "Prolonged Drug Release from Gels, using Catanionic Mixtures." Doctoral thesis, Uppsala University, Department of Pharmacy, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8303.

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<p>The use of catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining prolonged drug release from gels. It was shown that various commonly used drug compounds are able to form catanionic mixtures together with oppositely charged surfactants. These mixtures exhibited interesting phase behaviour, where, among other structures, vesicles and large worm-like or branched micelles were found. The size of these aggregates makes them a potential means of prolonging the drug release from gels, as only monomer drugs in equilibrium with larger aggregates were readily ab

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40

Veen, Jacoba van der. "A study on programmed drug release from tablets." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1993. http://irs.ub.rug.nl/ppn/293023646.

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41

Paulsson, Mattias. "Controlled Release Gel Formulations for Mucosal Drug Delivery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5173-X/.

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42

Chang, Rong-Kun. "Dual Polymer Microsphere Systems to control drug release /." Ann Arbor : University Microfilms International, 1985. http://www.gbv.de/dms/bs/toc/016417453.pdf.

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43

Fetherston, S. M. "Novel Sustained Release Divices for Vaginal Drug Administration." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527695.

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44

Dennis, Andrew Barriball. "Sustained drug release from semi-solid capsule formations." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328069.

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45

Hyde, Thomas Miles. "Transport in polymers : application to controlled drug release." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363822.

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46

Niknezhad, Sepideh. "STRATEGIC DESIGN OF NANOFIBER CARRIERS FOR DRUG RELEASE." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1513257280368733.

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47

Yeh, Hsi-wei. "Investigation of Polymeric Composites for Controlled Drug Release." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4971.

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The Electrospray (ES) technique is a promising particle generation method for drug delivery due to its capabilities of producing monodisperse PLGA composite particles with unique configurations and high drug encapsulation efficiency. In the dissertation work, the coaxial dual capillary ES was used to generate drug-loaded core-shell PLGA particles to study the effects of particle filling materials, drug loading locations and particle shell thicknesses on the resultant in vitro release behaviors of the hydrophilic and/ or hydrophobic model drugs. Through release profile characterization of drug-

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48

FARINA, MARCO. "Implantable medical devices for drug and cell release." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2709325.

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This work is focused on the research on how to leverage 3D printing technology in the field of cell transplantation. More specifically, the study of an artificial organ for hormone replacement therapies thanks to the close collaboration between the Methodist Hospital Research Institute, Houston, Texas and Politecnico di Torino, Turin, Italy. Cell transplantation offers an attractive therapeutic approach for many endocrine deficiencies. Transplanted endocrine cells or engineered cells encapsulated in the here presented 3D printed device, can act as biological sensors detecting changes in hormo

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49

Patel, Jitandrakumar Ramanbhai. "The kinetics of calcium-induced calcium release in the heart." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294077.

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50

Sutch, Jonathan C. D. "Optimising Microenvironmental pH and Drug Release from Formulations Containing a Weakly Basic Drug." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489694.

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The release ofpapaverine, a weakly basic drug, is pH dependent. To allow drug release throughout the changing pH milieu ofthe gastrointestinal tract, weak acid modifiers are often added to modify the microenvironmental pH. A technique to measure the microenvironmental pH by confocal microscopy (CLSMpH) has been optimised to allow accurate measurement in coated pellets. A central composite design was used to investigate the effect of formulation factors on drug release and CLSMpHÃ‚Â• Acid modifiers and fillers of varying solubility were also investigated. The solubility and proportion ofthe aci

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