Academic literature on the topic 'Kits genre'
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Journal articles on the topic "Kits genre"
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FROW, JOHN. "“Reproducibles, Rubrics, and Everything You Need”: Genre Theory Today." PMLA/Publications of the Modern Language Association of America 122, no. 5 (2007): 1626–34. http://dx.doi.org/10.1632/pmla.2007.122.5.1626.
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If you had typed genre into amazon.com's search engine on a certain day in March 2007, you would have come up with an initial ten listings that included two gay men's magazines (Genre and Instinct Magazine), one introductory theoretical text (my own Genre), a compact disc by a group called D-Genre, a composition textbook (Tom Romano's Blending Genre, Altering Style: Writing Multigenre Papers), three resource kits for children (Carson-Dellosa's Literary Genres, Susan Ludwig's Twenty-Four Ready-to-Go Genre Book Reports: Engaging Activities with Reproducibles, Rubrics, and Everything You Need to Help Students Get the Most Out of Their Independent Reading, and a bulletin-board set entitled BB Set Genres of Lit), and, finally, two school textbooks (Tara McCarthy's Teaching Genre (Grades 4–8) and Heather Lattimer's Thinking through Genre: Units of Study in Reading and Writing Workshops 4–12).
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Gunawan, Agnes Paulina. "Genre Fotografi yang Diminati oleh Fotografer di Indonesia." Humaniora 5, no. 2 (2014): 1234. http://dx.doi.org/10.21512/humaniora.v5i2.3266.
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When speaking of progress, photography is one of the things that is experiencing a quite vast development, and relatively wide in terms of technology or its visual feature. What it means by visual feature here is that in a long period of time, a lot has changed in its idea or concept. Also, it means the print media, or even its printing technique. Moreover he most basic of all is its character of the result in the photo itself. Whether the object taken, moment or time of the photo shoot, all these factors quite represent several genres in photography. For example, if the photography is making a human being to become its model, it might mean a modeling photo shoot, kids, or family photo shoot. Also it might mean a studio/indoor photo shoot or an outdoor photo shoot, when speaking of genre category. If the photo taken is a moment or an event, it might be a journalistic genre or a documentation one. Several themes or visual feature in a photo shoot will become one of the aspects for us the subject to be able to categorize the kind of genre they are. Hence, those genres definitely serve different functions.
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Maleachi, Martus Adinugraha, and Martus Adinugraha Maleachi. "Karakteristik dan Berbagai Genre dalam Kitab Mazmur." Veritas : Jurnal Teologi dan Pelayanan 13, no. 1 (2012): 121–40. http://dx.doi.org/10.36421/veritas.v13i1.250.
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Kitab Mazmur ditulis dalam bentuk puisi. Bagi orang Yahudi, puisi merupakan jenis literatur yang memegang peranan penting karena melengkapi apa yang tidak dapat diberikan oleh prosa; puisi merupakan ungkapan emosi yang menyatakan kedalaman iman dan ibadah mereka. Oleh sebab itu, kita perlu bukan hanya menganalisa suatu mazmur, tetapi juga mengapresiasinya. Mazmur merupakan ungkapan kata-kata penulis kepada Allah dan tentang Allah. Berbeda dengan kebanyakan bagian Alkitab yang lain, dalam kitab Mazmur Allah memakai pergumulan hidup manusia untuk menguatkan umat percaya lainnya. Mazmur adalah respons keberadaan manusia di hadapan Allah, baik melalui pengalaman (mis. kesulitan hidup, peperangan, sakit penyakit, pernikahan, kelahiran, kematian dan sebagainya) maupun perasaan hatinya (sukacita, ketakutan, kebencian, depresi, dan sebagainya). Perlu dipahami bahwa di dalam sebuah mazmur ada tiga unsur yang perlu diperhatikan. Pertama adalah isi (content) dari mazmur tersebut. Kedua adalah bentuk dari mazmur tersebut. Terakhir adalah efek yang ditimbulkan oleh mazmur tersebut. Isi merupakan ungkapan hati dari pemazmur yang melibatkan emosi, imaginasi, dan pesan yang ingin disampaikan. Bentuk dari mazmur, seperti susunan bait, sanjak, dan genrenya mendukung isi dari puisi tersebut dan menimbulkan keindahannya. Paduan kedua unsur tersebut menimbulkan sebuah efek yang berbeda dengan prosa. Pada waktu menafsir sebuah mazmur, kita bukan hanya memperhatikan arti, tetapi juga keindahannya. P. D. Miller mengingatkan bahwa kita perlu lebih sensitif terhadap karakteristik puitis dari suatu mazmur agar kita dapat mengalami pesan dari pemazmur dalam kehidupan pribadi kita. Artikel ini akan mengajak pembaca untuk mengenai kitab Mazmur dan menafsirkannya.
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Latocha, Sebastian. "Spóźniony gość w cudzym świecie: konteksty trudnego dziedzictwa." Kultura i Społeczeństwo 64, no. 2 (2020): 207–16. http://dx.doi.org/10.35757/kis.2020.64.2.11.
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In this article, the author discusses Monika Sznajderman’s reportage Pusty las [The Empty Forest] in the context of Geertz’s blurred genres. The author mainly addresses the condition of a person (a researcher, an anthropologist) who does not explore the Other but is the Other. In Sznajderman’s book, hospitality is a basic category; the researcher studying a difficult heritage — here, the Lemko region — is a guest who must choose either to look at or to ignore the history of his or her hosts. He or she can feel at home or erase all trace of the hosts’ presence. Perhaps in the end, as Maria Stepanova writes, the researcher can “breathe the air of post-memory.” The author treats Sznajderman’s book as an example of anthropological reportage and postulates the emergence of a new genre, on the border between the social sciences and literature.
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Korzheva, Alina Evgenievna. "Genre-based tradition of happy ending in Ye. Zamyatin’s Tales." SHS Web of Conferences 122 (2021): 02003. http://dx.doi.org/10.1051/shsconf/202112202003.
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The article deals with Ye.I. Zamyatin tales from the perspective of their compliance with the genre canons of a fairytale. The authors explore the Tales of Fita cycle as well as the tales “The Devourer” and “The Church of God” included in the collection “Big Kids’ Fairytales”. Special attention is paid to the endings of tales; the authors analyze their correspondence to the canons of folklore and literary fairytales formulated by the researchers of this genre: V.Ya. Propp, V.P. Anikin, and I.P. Lupanova. There is a mixture of the fairytale genre with the genre of socio-political satire in Ye.I. Zamyatin’s analyzed works. The authors analyze the plot and stylistic means used by the writer, their compliance with the standard canon. Within the study, the authors rely on the results of existing research in this area and attempt to explore the writer’s work in a new context. Traditionally works in the field of literary research into Ye.I. Zamyatin’s work focus on the dystopian motives and the analysis of political overtones in the writer’s satirical works. At the same time, the genre-related features of Ye.I. Zamyatin’s early works remain poorly understood and require particular academic attention. The novelty of this study consists in the fact that the study is focused on the analysis of the genre structure of Zamyatin’s “tales”. The authors use the method of comparative analysis, problem-logical, functional and systemic methods. The study allows one to determine the degree to which Ye.I. Zamyatin’s tales correspond to traditional plot-related and “formulaic” devices used in the endings of folk and literary fairy tales as well as study the specific features of mixing the genres of fairytale and satire in the famous Russian writer’s works.
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Azis, Moch Abdul, Nur Hadianto, Jaja Miharja, and Saifulloh Rifai. "IMPLEMENTASI ALGORITMA APRIORI UNTUK ANALISA PEMILIHAN TIPE GENRE FILM ANIME (STUDI KASUS : MYANIMELIST.NET)." Jurnal Pilar Nusa Mandiri 14, no. 2 (2018): 209. http://dx.doi.org/10.33480/pilar.v14i2.932.
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Seperti halnya film animasi jepang atau bisa juga di sebut dengan film anime yang kini mulai banyak digemari oleh semua kalangan tanpa pandang umur, status dan profesi. Pada film anime jepang ini memiliki memiliki beberapa genre dari action, comedy, drama, romance, adventure dll, bisa diakses seperti pada media online seperti website yang menyajikan macam-macam genre anime salah satunya adalah myanimelist.net pada web ini memiliki 14.000 film anime berbagi genre. Salah satu cara untuk meningkatkan daya tarik film anime adalah dengan pemanfaatan data pelihan genre yang sering di tonton oleh para penikmat film anime. Dengan data tersebut kita busa menganalisa tipe genre apa yang paling banyak di tonton, serta kecenderungan pemilihan tipe genre alternatif yang disukai oleh para penikmat film anime. Sehingga dengan data-data tersebut pihak creator bisa menentukan strategi untuk realese tipe genre yang akan dibuat berikutnya. algoritma apriori bagus untuk digunakan untuk pembentukan itemset, pencarian pola dan lain sebagainya. Maka dari itu pada penelitian kali ini Algoritma apriori digunakan untuk menentukan pola pemililihan tipe genre pada Film Anime Jepang.
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Kurniawan, Rendya Adi. "KEBUDAYAAN LOKAL DALAM KOMIK SUPERHERO INDONESIA." INVENSI 2, no. 1 (2017): 9–15. http://dx.doi.org/10.24821/invensi.v2i1.1803.
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Komik merupakan suatu bacaan yang populer di Indonesia. Terdapat beragam genre komik yang dapat kita nikmati. Mulai komik dalam genre wayang, silat, roman remaja sampai komik dengan genre superhero. Komik superhero Indonesia sendiri sudah mulai berkembang, hingga saat ini komik superhero Indonesia menjadi populer di masyarakat. Beberapa diantaranya adalah Sri Asih karya Kosasih, Gundala karya Hasmi, hingga yang terbaru adalah Volt karya Marcelino Lefrant. Terlepas dari nama-nama besar komikus pada eranya, kini komikus-komikus muda mulai bermunculan. Berbagai genre pun kembali dimunculkan. Namun tetap yang menonjol adalah genre superhero. Namun dibalik banyaknya bentuk komik superhero yang tak bisa diragukan lagi, sangat terpengaruh oleh gaya Barat dan Jepang, terdapat satu kesamaan yang coba diangkat oleh komikus-komikus muda ini, yaitu kebudayaan lokal. Penelitian ini akan mencoba mengaplikasikan metodologi visual dari Gillian Rose untuk melihat hubungan antara kebudayaan lokal dengan komik superhero Indonesia.
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Schmid, D., B. Bayer, and K. Anslinger. "Comparison of telogen hair analyses: genRES® MPX-2SP kit versus genRES® MPX-SP1 and genRES® MPX-SP2 kits." Forensic Science International: Genetics 3, no. 1 (2008): 22–26. http://dx.doi.org/10.1016/j.fsigen.2008.07.003.
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Afrom, Ichyatul. "Pengaruh Metode Pembelajaran Problem Solving Pada Pendidikan Seni Drama di PRODI PGSD Universitas Muhammadiyah Palangkaraya." Pedagogik: Jurnal Pendidikan 13, no. 2 (2018): 12–17. http://dx.doi.org/10.33084/pedagogik.v13i2.863.
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Problem solving dalam pendidikan juga sering diistilahkan dengan Pembelajaran berbasis masalah (Problem-Based Learning), Pengajaran berbasis proyek (Project-based education) dan Pembelajaran berdasarkan pengalaman (Experience-based education). Sedangkan dalam buku Desain Pembelajaran oleh Mukhtar disebutkan bahwa metode problem solving adalah suatu metode dalam PAI yang digunakan sebagai jalan untuk melatih siswa dalam menghadapi suatu masalah yang timbul dari dirinya, keluarga, sekolah maupun masyarakat, dari masalah yang paling sederhana sampai masalah yang paling sulit.6 Metode problem solving yang dimaksud adalah suatu pembelajaran yang menjadikan masalah kehidupan nyata, dan masalahmasalah tersebut dijawab dengan metode ilmiah, rasional dan sistematis.
Dalam kehidupan sekarang, drama mengandung arti yang lebih luas ditinjau apakah drama sebagai salah satu genre sastra, ataukah drama itu sebagai cabang kesenian yang mandiri. Drama naskah merupakan salah satu genre sastra yang disejajarkan dengan puisi dan prosa. Drama pentas adalah jenis kesenian mandiri yang merupakan integrasi antara berbagai jenis kesenian seperti musik, tata lampu, seni lukis (dekor, panggung), seni kostum, seni rias, dan sebagainya. Jika kita membicarakan drama pentas sebagai kesenian mandiri, maka ingatan kita dapat kita layangkan pada wayang, ketoprak, ludruk, lenong, dan film.
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Czaja, K., A.-S. Borer, L. Schmied, G. Terszowski, M. Stern, and A. Gonzalez. "A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs." Genes & Immunity 15, no. 1 (2013): 33–37. http://dx.doi.org/10.1038/gene.2013.58.
Full textDissertations / Theses on the topic "Kits genre"
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Salaverry, Pietro Barbiani. "Proposta de metodologia de implantação de plano para cada peça e introdução do sistema de abastecimento por kits." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/127912.
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Esta dissertação contempla uma proposta de metodologia para implantação de Plano Para Cada Peça e introdução do sistema de abastecimento por kits. Contemplados em dois artigos, onde respectivamente no primeiro foi desenvolvida uma ferramenta para captura de dados, um método de como estruturá-los, como organizá-los em um banco de dados e interpretá-los de acordo com as características do produto e produtivas para definição do método de abastecimento. No segundo artigo, foi proposta uma metodologia de introdução do processo de abastecimento por kits, onde de acordo com as características do produto e do processo produtivo, foram definidos: os layouts das áreas de separação e sequenciamento de peças, a quantidade de entradas de abastecimento, a quantidade de peças necessárias em cada kit, a disposição das peças e layout dos kits, o processo de separação de peças e montagem dos kits, assim como os carros de movimentação e abastecimento na linha.This dissertation includes a methodology proposal for deploying Plan For Every Part and implement the kit line feeding. Conceived respectively in two articles, on the first one was developed a tool for data capture, a method of how to structure, arrange in a database and interpret it according to product and production characteristics for setting the supply method. The second article presents a method to introduce the process by kits supply, which according to the product characteristics and the production process were defined: the parts picking and sequencing area layouts, the amount of supply inputs, the required quantity of parts in each kit, the layout and parts arrangement of kits, the picking process and kits assembly, as well as the handling and supply cars to the assembly line.
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Tourlaki, Athanasia <1973>. "The KIT gene in familial mastocytosis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5590/.
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Familial cutaneous mastocytosis is an exceptional condition of unknown etiology. In this study we report the largest series of patients with familial cutaneous mastocytosis without other manifestations (18 affected subjects from seven unrelated families), and we investigate the role of germ-line KIT mutations in the pathogenesis of the disease. The mean age at onset was 5.4 years (range from birth to 22 years), and the clinical behavior was variable over a mean follow up period of 15.1 years (range 2-36): improvement in seven, stability in eight and worsening in the remaining three patients. The pattern of inheritance was compatible with an autosomal dominant trait with incomplete penetrance; a female preponderance (14 females vs 4 males, ratio 3.5:1) was noted; among the six women who have been pregnant at least once, three experienced important clinical changes during pregnancy. No germ-line mutation was found in the exons 10, 11, and 17 of the KIT proto-oncogene, which are the most commonly mutated exons in sporadic mastocytosis. However, in the majority of affected subjects we found the Met541Leu polymorphic variant of the KIT gene, which seems to confer a growth advantage to mast cells in vitro. This observation further suggests that the Met541Leu may be a predisposing factor of cutaneous mastocytosis, although it seems to be neither necessary nor sufficient for the development of the disease.
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An, Ningfei, Bo Cen, Houjian Cai, Jin H. Song, Andrew Kraft, and Yubin Kang. "Pim1 kinase regulates c-Kit gene translation." BIOMED CENTRAL LTD, 2016. http://hdl.handle.net/10150/622957.
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Background: Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. Methods and results: We demonstrated that loss of Pim1 led to specific down-regulation of c-Kit expression in HSPCs of Pim1(-/-)mice and Pim1(-/-)2(-/-)3(-/-) triple knockout (TKO) mice, and resulted in attenuated ERK and STAT3 signaling in response to stimulation with stem cell factor. Transduction of c-Kit restored the defects in colony forming capacity seen in HSPCs from Pim1 (-/-) and TKO mice. Pharmacologic inhibition and genetic modification studies using human megakaryoblastic leukemia cells confirmed the regulation of c-Kit expression by Pim1 kinase: i.e., Pim1-specific shRNA knockdown down-regulated the expression of c-Kit whereas overexpression of Pim1 up-regulated the expression of c-Kit. Mechanistically, inhibition or knockout of Pim1 kinase did not affect the transcription of c-Kit gene. Pim1 kinase enhanced c-Kit S-35 methionine labeling and increased the incorporation of c-Kit mRNAs into the polysomes and monosomes, demonstrating that Pim1 kinase regulates c-Kit expression at the translational level. Conclusions: Our study provides the first evidence that Pim1 regulates c-Kit gene translation and has important implications in hematopoietic stem cell transplantation and cancer treatment.
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Ji, Ke. "Implication of metastasis suppressor gene, KISS-1 and its receptor KISS-1R in colorectal cancer, molecular and cellular mechanisms." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/49221/.
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Kiss-1 and its receptor (Kiss-1R) are suggested as a novel pair of metastasis suppressors for several human solid tumours. However, the role of Kiss-1 and Kiss-1R in colorectal cancer remains largely unknown. Therefore, the aim of this study was to investigate the role and signal transduction of Kiss-1 and its receptor in colorectal cancer. Colorectal cancer cell lines (HT115, HRT18, RKO and Caco-2) were screened for the mRNA expression levels of Kiss-1 and Kiss-1R. Sublines of cancer cells with differential expression of Kiss-1 and Kiss-1R were created, using ribozyme transgenes to knock down the expression of Kiss-1 and Kiss-1R, respectively. The stabilized transfected cells were used to study the influence of Kiss-1 and Kiss-1R on the function of colorectal cancer cells using by in vitro function assays (growth, adhesion, wounding and invasion assays) and ECIS assay. The influence of Kiss-1 on tumour growth was also tested using an in vivo tumour model. To further explore the receptor activation and signalling pathways downstream of Kiss-1, Kisspeptin-10 was also used in HT115 Kiss-1 knockdown cells. Phosphorylation of Kiss-1 and the effect of Kissthe effect on MMP 1 on MMP 1 on MMP-9 and MMP and MMP -2 were detected using immunoprecipitation and immunoprecipitation and zymographyzymography respectively. The study also investigated Kiss-1 and Kiss-1R expression and their correlation to the clinical outcome in human colorectal cancer, using real-time PCR and immunohistochemistry. Kiss-1 and Kiss-1R played a suppressive role in the invasion and migration of colorectal cancer cells, in that knocking down both Kiss-1 resulted in increased cell-matrix invasion and cellular migration as demonstrated by a series of cell models. Exogenous Kiss-1 (Kisspeptin-10) decreased cellular migration of colorectal cancer cells and required ERK signalling as shown during the ECIS based analyses. The inhibitory influence of Kiss-1 on the motility of cancer cells was via the reduction of MMP-9, shown by zymography. In the in vivo tumour model, tumour growth rate of Kiss-1 knockdown colorectal cancer cells was significantly faster than the control cells. In human colorectal cancer tissues, levels of message expression of Kiss-1 had a negative correlation with Dukes staging, TNM staging, tumour size and lymph node involvement. Kiss -1R expression was significantly decreased in tumour tissues compared with adjacent normal tissues. The present study has demonstrated that Kiss-1 and Kiss-1R play a pivotal tumour suppressor role in colorectal cancer. The inhibitory effect on cancer cells involves the regulation of MMPs and the ERK signaling pathway. The molecule pair is candidate prognostic indicator in patients with colorectal cancer.
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Hepp, Diego. "Influência dos genes candidatos MC1R, ASIP, TYRP1 e kit na pigmentação em ovinos crioulos e predição do efeito dos polimorfismos não sinônimos no gene MC1R humano." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119623.
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A coloração dos animais é uma característica que apresenta uma grande diversidade de fenótipos nas diferentes espécies. Diferentes abordagens podem ser utilizadas para o entendimento da diversidade na coloração existente nas espécies animais. Através da análise de genes candidatos as mutações responsáveis pela variação na coloração têm sido descritas em diferentes espécies, demonstrando o envolvimento de mecanismos moleculares variados na sua regulação. Este trabalho tem por objetivo a utilização de duas abordagens genéticas para o estudo da variação na coloração, a análise de genes candidatos e a predição computacional do efeito de polimorfismos não sinônimos. Em ovinos a coloração da lã é uma característica com importância na produção e para a identificação das raças. Polimorfismos em diferentes genes foram associados com a coloração da lã, entretanto, estes não foram estudados em muitas raças que apresentam variação fenotípica. A ovelha crioula é uma raça local existente no sul do Brasil que apresenta uma ampla diversidade de cores na lã, incluindo branco, preto e diversos tons intermediários. O gene receptor de melanocortina 1 (MC1R) foi previamente associado com a coloração na raça crioula, entretanto, outros genes também devem estar envolvidos na regulação da coloração na raça. Este trabalho avaliou a influência dos genes MC1R, ASIP (proteína sinalizadora agouti), TYRP1 (proteína relacionada à tirosinase 1) e KIT (homólogo do oncogene de sarcoma felino viral v-kit Hardy-Zuckerman 4) na coloração da lã na raça ovina crioula. Amostras de 410 animais de diferentes cores foram analisadas, sendo a variação na coloração da lã determinada por colorimetria. O padrão de herança dos fenótipos foi avaliado através de cruzamentos dirigidos entre indivíduos de diferentes cores. Os polimorfismos nos genes foram avaliados através da realização do sequenciamento e da análise de fragmentos e a quantificação da expressão do gene ASIP foi realizada por PCR em Tempo Real. Foi observada a associação significativa entre polimorfismos nos genes MC1R e ASIP e a cor da lã na raça crioula. O alelo dominante do gene MC1R, provocado pelas mutações p.M73K e p.D121N, foi encontrado apenas em indivíduos pigmentados. Este alelo resulta na ativação constitutiva do receptor, e consequentemente na produção constante de eumelanina, sendo epistático sobre o gene ASIP. Nos animais homozigotos para o alelo selvagem do MC1R a manifestação do fenótipo branco ocorreu somente nos portadores de um alelo contendo a duplicação do gene ASIP. Os portadores da duplicação do ASIP apresentaram níveis elevados de expressão do gene enquanto os homozigotos para a cópia simples do ASIP não expressaram o gene e apresentaram fenótipos pigmentados. Os resultados obtidos permitiram identificar a influência da interação epistática dos genes MC1R e ASIP na coloração da lã nos ovinos crioulos. O estudo de genes candidatos envolvidos na rota da pigmentação mostrou-se uma abordagem adequada para a análise da variação na coloração nestes animais. Espera-se que o conhecimento adquirido neste trabalho auxilie na criação e na preservação da raça através da manutenção da diversidade fenotípica existente. A avaliação computacional dos polimorfismos não sinônimos vem sendo utilizada recentemente a fim de determinar os SNPs que potencialmente afetam o funcionamento dos genes e identificar os mecanismos responsáveis por doenças complexas e pela variação nos fenótipos. A predição do efeito de polimorfismos nos genes utilizando ferramentas computacionais apresenta-se como uma abordagem alternativa para o estudo da genética da coloração. O gene MC1R humano apresenta uma grande quantidade de polimorfismos alguns dos quais foram associados com a variação na pigmentação e com suscetibilidade a tumores de pele. Entretanto, muitas das variações existentes no gene não foram avaliadas quanto às suas consequências funcionais e o seu papel na variação da pigmentação. Foi realizada a predição computacional dos polimorfismos não sinônimos no gene MC1R humano com o objetivo de identificar os nsSNPs mais provavelmente danosos, e estabelecer aqueles com potencial efeito na função do MC1R. Foram utilizadas 11 ferramentas de predição individuais (SIFT, MutPred, Polyphen-2, PROVEAN, I-Mutant 3.0, PANTHER, SNPs3D, Mutation Assessor, PhD-SNP, SNPs&GO e SNAP) e dois programas consenso (PON-P e PredictSNP 1.0) para a análise de 92 nsSNPs localizados no gene. Os programas utilizados baseiam-se em métodos evolutivos, estruturais e computacionais, resultando na identificação dos 14 nsSNPs mais danosos (L48P, R67W, H70Y, P72L, S83P, R151H, S172I, L206P, T242I, G255R, P256S, C273Y, C289R e R306H). Apesar das diferenças nos resultados de cada programa a combinação dos diferentes métodos permitiu diferenciar os polimorfismos neutros dos danosos, mostrando concordância com os programas consenso. A predição computacional demonstrou ser uma abordagem eficiente para a identificação dos alelos danosos no gene MC1R e para a priorização de mutações para posteriores estudos funcionais e populacionais.Animal color is a characteristic that presents a large diversity of phenotypes. Different approaches can be used to understand the color diversity existing among and within species. Through analysis of candidate genes the mutations responsible for the color variation have been described in different species, showing the involvement of various molecular mechanisms of regulation. The objective of this work is the use of two genetic approaches to the study of color variation, the analysis of candidate genes and the computational prediction of non-synonym polymorphism effects (nsSNPs). In sheep the wool color is a feature with commercial importance and in identifying breeds. Polymorphisms in different genes have been associated with wool color, but they have not been studied in many breeds that show phenotypic variation regarding such a charactere. The Creole is a local breed from southern most Brazil that presents a wide range of wool color, varying from white to black, and including several intermediate hues. The melanocortin 1 receptor (MC1R) was previously associated with the wool color in the Creole, however, other genes might also be involved in the regulation of color in the breed. This study evaluated the influence of the genes MC1R, ASIP (agouti signaling protein), TYRP1 (tyrosinase related protein 1) and KIT (v-kit Hardy- Zuckerman 4 feline sarcoma viral oncogene homolog) in the Creole breed wool color. Samples from 410 specimens of different colors were analyzed. The variation in the color of the wool was performed by colorimetry. The inheritance pattern of the phenotypes was assessed by crossbreeding individuals of different colors. Polymorphisms in the genes were evaluated by performing sequencing and fragment analysis, and the quantification of the ASIP gene expression was performed by Real Time-PCR. It was observed a significant association between polymorphisms in MC1R and ASIP gene and the wool color in Creole breed. The dominant allele of the MC1R gene, caused by p.M73K and p.D121N mutations was found only in pigmented individuals. This allele leads to the constitutive activation of the receptor and therefore in constant production of eumelanin and is epistatic on the ASIP gene. In the homozygous to the wild-type allele of MC1R the manifestation of white phenotype occurred only in individuals with one allele containing a duplication of the ASIP gene. The carriers of the duplicated copy of ASIP showed high levels of gene expression while homozygous for the simple copy of the ASIP did not expressed the gene, and showed pigmented phenotypes. The results allowed the identification of the influence of epistatic interaction of MC1R and ASIP gene in the wool color in Creole breed. The study of candidate genes involved in the pigmentation pathway proved to be a suitable approach for the analysis of variation in pigmentation in these animals. It is expected that the knowledge acquired in this work will assist on stablishment of commercial breeding and preservation policies of this sheep breed. The computational evaluation of non-synonymous polymorphism has been used to determine SNPs that potentially affect the function of the genes and identify the mechanisms responsible for complex diseases and by the variation in phenotypes. The prediction of the effect of polymorphisms in genes using computational tools presents an alternative approach to the study of the genetic of coloration. The human MC1R gene has a large number of know polymorphisms, some of which were associated with changes in pigmentation and susceptibility to skin tumors. However, many existing variations in the gene have not been evaluated regarding the functional consequences and its role in the variation of pigmentation. Computational prediction of nonsynonymous polymorphisms was performed in the human MC1R gene in order to identify the most likely harmful nsSNPs and to establish those with potential effect on the function of MC1R. Eleven individual tools (SIFT, MutPred, Polyphen-2, PROVEAN, I-Mutant 3.0, PANTHER, SNPs3D, Mutation Assessor, PhD-SNP, SNPs&GO and SNAP) and two consensus programs (PON-P and PredictSNP 1.0) were used to the analysis of 92 nsSNPs located in the gene. The programs used are based in evolutionary, structural and computational methods, resulting in the identification of the 14 most damaging nsSNPs (L48P, R67W, H70Y, P72L, S83P, R151H, S172I, L206P, T242I, G255R, P256S, C273Y, C289R and R306H). Despite the differences in the results of the each program the combination of different methods allowed the differentiation of the neutral polymorphisms from the most damaging, showing agreement with the consensus programs. The computational prediction has proved to be an efficient approach for the identification of harmful alleles in the MC1R gene and for the prioritization of mutations for further functional and population studies.
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Mendonça, Ullyanov Bezerra Toscano de. "Análise de mutações do gene KIT em pacientes com melanoma de mucosa de cabeça e pescoço e relação clínica retrospectiva." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-14122015-114016/.
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Introdução: O melanoma mucoso de cabeça e pescoço (MMCP) é mais agressivo do que o melanoma cutâneo, marcadores prognósticos desta patologia não foram completamente esclarecidos devido a sua raridade. Em recentes estudos, algumas vias moleculares foram descritas na fisiopatologia destes tumores. Entre estas vias, existe a via da MAPK (Mitogen Activated Protein Quinase). Esta via de sinalização está envolvida no controle do crescimento celular, proliferação e migração, com um papel no desenvolvimento e progressão do melanoma. Além disso, a mutação do gene KIT foi identificada em melanomas, indicando a possibilidade de benefícios terapêuticos com o uso dos inibidores de tirosino-quinase. Objetivos: descrever a prevalência e características de mutações ativadoras do gene KIT em 28 pacientes com MMCP tratados no Instituto Nacional do Câncer-INCa; avaliar a relação entre a presença de mutação ativadora do gene KIT e evolução clínica dos pacientes tratados em relação ao estadiamento, sobrevida livre de doença e sobrevida global. Métodos: Estudo retrospectivo de coorte, foram incluídos 28 pacientes com MMCP tratados no INCA, entre 1998 e 2009. Foram analisados: estadiamento, tratamento primário, sobrevida livre de doença (SLD) e sobrevida global (SG). As curvas de sobrevida foram analisados utilizando o método de Kaplan-Meier, com software SPS 11.0. Análise KIT: O DNA foi extraído a partir de tecido incluído e fixado em parafina. O procedimento consiste de múltiplas etapas de desparafinização com xilol. Os restos celulares são precipitados por centrifugação e o DNA, no sobrenadante é utilizado nas reações de PCR (direto ou diluído). A análise mutacional do gene foi realizada utilizando-se a amplificação por PCR seguida pelo sequenciamento genômico. As análises são iniciadas pelo éxon 11, seguidas do éxon 9, 17 e 13. Resultados: Os pacientes eram predominantemente do sexo feminino (57%). A idade de apresentação variou de 27 a 85 anos. A região nasossinusal foi o sítio primário mais frequente (75%). Todos os pacientes foram submetidos a ressecção cirúrgica. Dezessete pacientes receberam radioterapia adjuvante (37%). As recorrências ocorreram em 82% dos pacientes. Presença de mutação de KIT foi encontrada em 7 casos (25%), três no éxon 9, 3 no éxon 11 e 1 no éxon 13. Fatores preditivos de recorrência foram índice mitótico (p = 0,05), invasão vascular (p = 0,043), e a disseminação perineural (p = 0,034). Não houve diferenças significativas na SLD e SG de acordo com a mutação KIT. Conclusão: A presente série incluiu 28 casos tratados. Sete casos (25%) tinham mutações ativadoras KIT. Esta descoberta sugere que existe um grupo de pacientes que poderiam se beneficiar com a terapia-alvo adequado com inibidores de tirosino-quinaseUnlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. In recent studies, some molecular pathways have been found to be involved in the pathogenesis of melanomas. Among these, there is a proliferative MAPK pathway (\"Mitogen Activated Protein Kinase\"). This signaling pathway is involved in controlling cell growth, proliferation and migration, with a role in the development and progression of melanoma. In addition, KIT gene mutation has been identified in melanomas, indicating that there may be potential therapeutic benefits of tyrosine kinase inhibitors. Objectives: Evaluation of KIT mutation prevalence in a subset of 28 patients with HNMM treated at a single institution, establishing the relationship between different mutations and outcome (DFS and OS). The primary end-point of the study was to define the incidence of KIT mutations in HNMM, including the relationship between KIT mutations with disease-free survival (DFS) and overall survival (OS) in HNMM. Secondary end-points were correlation among therapeutic options, histopathological findings, demographic data and clinical response. Methods: This retrospective study comprised data of 28 patients with HNMM treated at Brazilian National Cancer Institute (INCA) between 2000 and 2011. Clinical analysis included patients characteristics, staging, primary and palliative treatments, disease free survival and overall survival. Progression-free survival and overall survival were analyzed using the Kaplan-Meier method, with SPS 11.0 software. KIT analysis: paraffin blocks were selected following analyses of histologic preparations, enabling DNA extraction. Different DNA concentrations were employed in PCR amplifications, based on DNA integrity. PCR amplification of exon, 9, 11, 13 and 17 was performed. . Results: Patients were predominantly females (57%). The age of presentation ranged from 27 to 85 years. The sinonasal region was the most frequent primary site (75%). All patients underwent surgical resection. Seventeen patients received adjuvant radiotherapy (37%). Recurrences occurred in 82% patients. Oncologic mutations in KIT were found in 7 (25%) of seven tumors, 3 in exon 9, 3 in exon 11 and 1 in exon 13. Predictive factors for recurrence were mitotic rate (p=0.05), vascular invasion (p=0.043), and perineural spread (p=0.034). There were no significant differences in DFS and OS according to KIT mutation. Conclusion: HNMM remains a rare disease. The present single-institution series includes 28 cases treated in single institution. Seven cases (25%) had activating KIT mutations, which is an increased prevalence of activating KIT mutations in this specific subset of mucosal melanomas. This finding suggests that there is a group of patients who might benefit with appropriate targeted therapy with kinase inhibitors
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Bristow, Greg. "Investigations of the potential schizophrenia susceptibility gene Kinase Interacting with Stathmin (KIS)." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:432fc195-815c-4bc6-945f-c2b59aa3538c.
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Single nucleotide polymorphisms (SNPs) within the gene encoding the serine threonine kinase KIS (Kinase Interacting with Stathmin, also known as UHMK1) have recently been associated with schizophrenia. However, little is known about the neurobiology of KIS or the mechanisms through which disease-associated SNPs may increase susceptibility to schizophrenia. The studies presented in this thesis focus on the distribution of KIS and its mRNA, address the mechanisms through which KIS may confer susceptibility to schizophrenia, and investigate the physiological role(s) of KIS in the brain using two lines of knockout mice. The regional and cellular distribution of KIS was characterised in the brains of adult humans and mice, and through mouse neurodevelopment. The results of these experiments demonstrated that KIS is widely expressed in neurons in the brain regions examined in both species, its encoded protein is localised to the nucleus and cytoplasm, and KIS expression in mouse brain peaked around seven days after birth. KIS protein and mRNA was quantified in two large human post-mortem brain series to determine if KIS expression is altered in schizophrenia or bipolar disorder, or in relation to the leading schizophrenia-associated SNP (rs7513662). Using tissue from the superior temporal gyrus, dorsolateral prefrontal cortex, anterior cingulate cortex, and cerebellum, no difference in KIS expression (either mRNA or protein) was found between diagnostic or genotype groups in any brain region examined. Furthermore, KIS expression in lymphoblast cell lines also did not differ between diagnostic or genotype groups. Lastly, KIS expression (mRNA and protein) was characterised in two separate lines of KIS knockout mice. The results were complex, and left uncertainty as to whether either line was a true knockout or, conversely, whether any of the available KIS antibodies were specific. Nevertheless, the absence of KIS mRNA was robustly confirmed in one knockout mouse line, and brains from this line were subsequently used in three experiments. First, investigation of the quantity and phosphorylation state of the KIS targets stathmin and p27kip1; no differences were found compared to wildtype mice. Second, quantification of mRNA expression of several other genes of interest with regard to schizophrenia; altered expression of GAP43, VGlut1, MAP2, spinophilin, and stathmin was found. Finally, stereological measurements were performed, and while no differences in whole or regional brain volumes in KIS knockout mice were found, there was a relative reduction in hippocampal volume. The results of these studies do not support the hypothesis that altered expression is the mechanism by which genetic variation of KIS may increase susceptibility to schizophrenia, nor that KIS expression is altered in the disease. However, the knockout mice data suggest that KIS may play a role in synaptic plasticity and function, providing novel information on the potential neurobiological roles of KIS.
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Wong, Alexander Tsiong. "Aspects of the kiss-poem 1450-1700 : the neo-Latin basium genre and its influence on early modern British verse." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708782.
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Del, Romano Cecilia. "“Apri la testa e lancia i ruoli di genere dalla finestra”: Proposta di sottotitolaggio del documentario No More Boys And Girls: Can Our Kids Go Gender Free." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
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Quest’elaborato si propone come scopo quello di analizzare la seconda parte del documentario “No More Boys And Girls: Can Our Kids Go Gender Free”, prodotto da Outline Productions e mandato in onda dal canale inglese BBC Two ad Agosto del 2017, e proporne una traduzione sotto forma di sottotitolaggio (la tabella dei sottotitoli è allegata all’elaborato in appendice). Il video documenta l’esperimento del Dott. Javid Abdelmoneim in una classe di seconda elementare della scuola “Lanesend Primary School” presso l’Isola di Wight. L’obiettivo dell’esperimento è scoprire se eliminare le differenze di genere nell’ambiente in cui vivono i bambini e le bambine aiuti a migliorare le loro abilità e ad aumentare la loro fiducia in sé stessi. Poiché la disparità di genere in età adulta è il risultato di un’educazione differenziata tra i due sessi, il Dott. Abdelmoneim ricorre a delle strategie per eliminare queste differenze e far capire ai bambini e alle bambine che i giochi, i colori, gli sport e i mestieri non hanno niente a che vedere con il sesso biologico di una persona.
In questo elaborato esploreremo in un primo capitolo cos’è la traduzione audiovisiva, in particolare il sottotitolaggio ed i suoi aspetti tecnici. In seguito, il secondo capitolo tratterà l’applicazione degli studi di genere al campo dell’istruzione con una breve parentesi sulla situazione in Italia e un approfondimento sull’esperimento effettuato nel documentario.
Infine, il terzo capitolo analizzerà il lavoro di sottotitolaggio, illustrando le difficoltà incontrate e motivando la scelta delle soluzioni traduttive prese.
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Mironko, Beatrice Karekezi Uwamutara. "Students and teachers' views on factors that hinder or facilitate science students in mastering English for academic purposes (EAP) in Rwanda higher education." University of the Western Cape, 2013. http://hdl.handle.net/11394/2996.
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Philosophiae Doctor - PhDThis study explores second and third year students' and teachers‟ views on factors that hinder or facilitate the mastery of English for Academic Purposes (EAP) in the Science and Engineering Technology Higher Institutions of learning in Rwanda (KIST) and seeks to establish the extent to which the current programme meets the needs of the students. This is done by highlighting a whole range of teacher and student perspectives on the EAP programme. Two key requirements invite students to write their academic assignments in the form of research proposals and research project reports. In order to help them perform well in their field subjects, KIST introduced a department of English with a General English Programme under the umbrella of the then School of Language Studies (SORAS) in 1997. The department‟s first assigned mission was to teach English to students in all departments in a bid to support and encourage them to cope with their field specific courses which are taught in English. Rwanda‟s National Council for Higher Education (2007), on language teaching and learning, states that the trio, that is Kinyarwanda (the Mother Tongue and national language) and English and French (as foreign languages), should be taught at primary, secondary and higher education levels in order to reconcile the divide between Rwandan returnees (who had lived abroad for many decades) and locals. It is in this context that KIST, one of the institutions of higher learning, adopted the bilingual policy to cater to students‟ needs to learn both French and English as media of academic communication. However, after Rwanda‟s integration into the East African Community and the Commonwealth, English has been officially adopted as the medium of instruction in all schools and higher institutions of education. That is why there was a sudden language shift in 2006 from French to English as a medium of instruction at KIST. French and Kinyarwanda are now merely taught as subjects. The motive behind the move was to cater for Rwanda‟s needs to fully participate in the economic community of East African Community in general and in the global economy in particular. The move drastically affected students‟ ability to read and write English in their respective disciplines. The move also affected lecturers of other speciality areas. To avert the obvious challenges emanating from this sudden shift in language policy, the Institute introduced the English for Specific Purposes (ESP) and English for Academic Purposes (EAP) programmes under the then KIST School of Language Studies (SOLAS) and the KIST Language Centre. However, appropriate instructional materials for such courses have not been easily available. Given this situation, English teachers have had to create their own materials rather than the existing generalised and pre-packaged language teaching materials. As a result, students‟ specific needs for induction into a scientific writing community at tertiary level have rarely been met. It is against this background that the study seeks to investigate factors that are facilitating and the mastery of EAP. The study operates on post-colonial/post-structuralist theoretical perspectives. These were founded on the analytical framework that is guided by thematic and/or conceptual underpinnings of language policy in the post-colonial Africa. Thus, English Language Teaching (ELT), developed into English as a second and additional language that is multi-semiotic and multi-modality in EAP and science genres, focusing mostly on its academic literacy, identity, ideology, power and agency, as well as its investment in language teaching and learning and the scientific community practice. Using a combination of ethnographic principles/practices like participants‟ observations, oneto- one interviews, focus group discussions and documentary review in data collection, the study utilises thematic/conceptual analysis to draw its conclusions. Drawing from the above conceptual perspectives, therefore, as well as from the methodological approach, this thesis emphasises the fact that the inability of students to successfully master EAP is caused by various factors, including the choice of English language learning materials. Contradictory approaches to language learning and to academic literacy practices create further challenges to the Rwandan students‟ advancement in English mastery. These same practices also serve to limit the students‟ ability to learn this language and complicate their access to local and global cultural exposure that is necessary for their socio-economic development of Rwanda. The study also reveals lack of appropriate discursive competence and multi-semiotic repertoires as some of the major factors inhibiting students‟ academic progress. This is partly explained by the nature of the English language learning and teaching materials that is in use which neither provides general nor disciplinary specific academic and learning opportunities in English. Similarly, a range of structural and professional constraints on „agency‟ exists for teachers of English in Rwanda as an additional language to the students, including lack of induction into scientific discourses or the EAP community of language practice. The overall lack of power and agency by teachers also contributes to constraints and constrictions in English language learning practices for these students in Rwanda. The study, however, observes that this situation is not only peculiar to KIST, as it is also common in almost all tertiary institutions in Rwanda. Specific recommendations are made in the study to improve the quality of English language learning and teaching in general and EAP in particular at KIST as an institution of higher learning, through the establishment of a clearer language policy and training opportunities for staff to update and develop required language skills in EAP, especially with regards to writing skills in sciences and engineering. The government of Rwanda, under the umbrella of Rwanda Education Board (REB) and the contribution of English language experts at the Institute, should provide a clearer direction of the language policy and curriculum that addresses Rwandan students‟ specific needs. KIST, as an institution of higher learning, should value and facilitate the teaching and learning of English in general and the teaching of EAP in particular, bearing in mind its assigned mission. The management of the Institute should encourage interaction between EAP and subject area lecturers to discuss and agree upon, text types to be used by EAP lecturers in teaching. KIST management should also provide room for regular interactions with English lecturers to listen to their views and offer them further language training opportunities in order to update and develop the required skills in EAP, especially with regards to writing skills in science and engineering.
South Africa
Books on the topic "Kits genre"
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30 biography book reports: Easy and engaging hands-on literature response projects that help kids of all learning styles explore the genre of biography. Scholastic Professional Books, 2001.
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Brennan, Matt. Kick It. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190683863.001.0001.
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The drum kit—the combination of kick drum, snare drum, and cymbals—has provided the pulse of popular music from before the dawn of jazz up to the present day pop charts. This book is a provocative social history of the instrument that looks closely at key innovators in the development of the kit: inventors and manufacturers like the Ludwig and Zildjian dynasties, jazz icons like Gene Krupa and Max Roach, rock stars from Ringo Starr to Keith Moon, and popular artists who haven't always got their dues as drummers, such as Karen Carpenter and J Dilla. Addressing a seeming contradiction – the centrality of the drum kit on the one hand, and the general disparagement of drummers on the other—this book makes the case for the drum kit’s role as one of the most important and transformative musical inventions of the modern era. Going beyond its purely musical history, it uses the instrument to replay the wider history of the United States and to chart the rise of the drum kit’s global economic and cultural influence. Tackling the history of race relations, global migration, and the changing tension between high and low culture, it shows how the drum kit, drummers, and drumming helped change modern music—and society as a whole—from the bottom up.
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Siebert, Lynn Laitman. Kiss Me, Kate. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252040092.003.0015.
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This chapter examines Porter's Kiss Me, Kate. Written in 1948, it holds a unique place in Porter's career and represents the fullest flowering of his mature talent. Porter met the challenge of the “new style musical comedy” by composing Kiss Me, Kate and simultaneously surpassed his past triumphs while establishing a new standard for the genre. The score's subtle refinement, depth of expression, and inventiveness, as well as the total integration of music, lyrics, and libretto, distinguish Kiss Me, Kate as Porter's masterwork. Kiss Me, Kate opened on Broadway at the New Century Theatre on 30 December 1948, with a run of 1,077 domestic performances and subsequent international performances.
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Rahman, Azmi. Jom Berpuisi: Pantun, Syair, Soneta & Gurindam. UUM Press, 2019. http://dx.doi.org/10.32890/9789672210375.
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Buku ini dihasilkan berdasarkan pengalaman Azmi Rahman meneliti, mengkaji dan mencipta pantun, gurindam, syair dan soneta. Tiga buah buku pantun Azmi Rahman telah diterbitkan oleh UUM Press, manakala buku soneta yang dihasilkan bersama tiga pengarang telah diterbitkan E-Sastera Enterprise. Kita sedia maklum bahawa genre soneta sebagai puisi moden belum lagi popular, tidak seperti sajak. Buku ini memuatkan maklumat ringkas tentang genre pantun, gurindam, syair dan soneta. Setiap genre diberikan contoh-contoh sama ada oleh pengarang lain atau saya sendiri dan disediakan ruang untuk penciptaan karya. Bagi genre pantun, maklumat diberikan agak terperinci, iaitu meliputi pengenalan, kajian terhadap pantun, pantun terjemahan dan penciptaan pantun empat kerat dan pantun berkait. Bagi genre gurindam, maklumat ringkas tentang gurindam diberikan dan disertakan huraian makna Gurindam Dua Belas karangan Raja Ali Haji. Penulis berharap buku itu boleh menjadi modul untuk apresiasi dan penciptaan genre pantun, gurindam, syair dan soneta. Dengan terhasilnya pelbagai puisi Melayu tradisional dan soneta, maka akan bertambahlah khazanah karya sastera Melayu buat tatapan dan kajian generasi akan datang.
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Simmons, Gene. Sex Money Kiss (Gene Simmons Family Jewels). Phoenix Books, 2006.
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Stone, Sam. Killing Kiss (Vampire Gene) by Stone, Sam (2008) Paperback (Vampire Gene Trilogy). The House of Murky Depths, 2008.
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Ready-To-Go Management Kit for Teaching Genre: Dozens of Engaging Response Activities to Use With Any Book That Help Kids Explore 10 Genres Independently. Teaching Resources, 2002.
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Pop-Up Activities to Teach Genre: 18 Unique Pop-Up Projects With Templates, Story Starters, and Graphic Organizers That Motivate Kids to Write in Different Genres. Teaching Resources, 2005.
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Ignite Your Inner Genie: Your Wish Is Your Command For Kids. Ignite Success, 2013.
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Notebooks, Gene's. Gene Legendary Gamer: Lined Notebook / Journal Gift, 6 X 9 Inches, Gene Funny Video Games, Boys Legendary Gamer Gene Gift, Personalized Gift Idea for Gene, for Students, Teens, and Kids. Independently Published, 2020.
Book chapters on the topic "Kits genre"
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Troen, Bruce R. "The Gene Construction Kit." In Sequence Data Analysis Guidebook. Humana Press, 1997. http://dx.doi.org/10.1385/0-89603-358-9:257.
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Seth, John. "Calcitonin Gene Related Peptide." In The Immunoassay Kit Directory. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1414-1_9.
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Rossi, P., C. Sette, A. Bevilacqua, F. Mangia, and R. Geremia. "Role of c-kit in Egg Activation." In Testicular Function: From Gene Expression to Genetic Manipulation. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03671-6_13.
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Kaslow, Florence W. "Case 8 Mr. Gene Goodman: My Life Revolves Around My Kids Now." In Divorced Fathers and Their Families. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5535-6_9.
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Brennan, Matt. "Studious drummers, selling drum outfits, standardization, and stardom." In Kick It. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190683863.003.0004.
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Literacy, education, and standardization were key steps forward in consolidating the drum kit’s legitimacy in the 1930s. This chapter examines the biographies of many early drummers and how they learnt to play the drum kit. Arguments over how to play the drum kit were inseparable from the changing form of the drum kit itself, as manufacturers like Ludwig, Slingerland, Leedy, and Gretsch competed to sell standardized, pre-bundled drum kits in their catalogues rather than the hodge-podge, self-assembled drum kits of the past. This chapter discusses the creation of an international market for drum kits through a combination of instrument innovation, education, and old-fashioned hucksterism. Drum manufacturers created their own newsletters as a way of convincing drummers to buy their product. The chapter also examines the career of swing era drummer Gene Krupa, comparing him with African-American drummer Chick Webb, an influential but less well known drumming bandleader.
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Mak, Tak W., Josef Penninger, John Roder, Janet Rossant, and Mary Saunders. "c-kit." In The Gene Knockout FactsBook. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012466044-1/50363-x.
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Hesketh, Robin. "KIT." In The Oncogene & Tumour Suppressor Gene Factsbook. Elsevier, 1997. http://dx.doi.org/10.1016/b978-012344548-3/50050-9.
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Brennan, Matt. "Creative drummers, artistry, virtuosity, and playing time." In Kick It. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190683863.003.0005.
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This chapter explores the drummer as a creative artist versus their role as an accompanist and timekeeper. This chapter picks up in the late 1930s, when star drummers like Buddy Rich set new standards for virtuosity on the drum kit, and drum battles became popular displays of technical skill and showmanship. It also discusses the ‘all-girl’ swing bands of the 1930s and 1940s, focusing on the case of drummer Viola Smith. The chapter describes the increasingly prominent role of the drummer in the new bebop style of the 1940s, focusing on two of the drum kit’s greatest musical innovators, Kenny ‘Klook’ Clarke and Max Roach. It also traces the origins of the ‘four-on-the-floor’ pulse of the bass drum and backbeat on two and four of the snare drum that came to dominate dance music through the twentieth century to the present day. The chapter concludes with the drum kit’s second global superstar after Gene Krupa: Ringo Starr of the Beatles.
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Sherbet, Gajanan V. "The Metastasis Suppressor KiSS-1 Gene." In Therapeutic Strategies in Cancer Biology and Pathology. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-416570-0.00012-3.
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Juffer, Jane. "TV’s Narratives for Emotional Management." In Don't Use Your Words! NYU Press, 2019. http://dx.doi.org/10.18574/nyu/9781479831746.003.0006.
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This chapter argues that much programming for younger children on Nick Jr., Disney Jr., and PBS encourages them to manage their emotions and limit their affective, bodily responses through a focus on problem solving. These shows also advocate empathy and tolerance, teaching kids how to recognize and respond to others’ feelings. Many shows segue from emotional management to an appreciation of difference, thus contributing to the wider discourse of diversity management. In a stark shift from the years when television was seen as harming children’s development, many therapists now urge parents to use television to help their children learn prosocial behavior. However, television cannot be homogenized; a genre of “sideways growth” programming encourages kids to defy proper behavior, to revel in their bodies, and to occupy spaces of intensely affective pleasure. These shows interrupt the linear narratives that characterize problem-solving approaches and thus introduce the idea of alternative modes of communication.
Conference papers on the topic "Kits genre"
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Fleming, Paul, and Tara Dalton. "One-Step Reverse-Transcription PCR on a High-Throughput Micro-Fluidic Device." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206623.
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One step reverse-transcription polymerase chain reaction (RT-PCR) assays are an attractive option for further automating gene detection assays. One-step assays can reduce hands–on-time and the risk of sample crossover and contamination. The one-step chemistries are showing increasing use in virus detection and have been reported, in some cases, to be more appropriate than their two-step counterparts [1, 2]. Previous work presented by the Stokes Institute research group outlined a micro fluidic based continuous flow instrument which performed high throughput qPCR in nanolitre sized droplets [3]. This instrument had advantages over commercially available instruments in that it could process far more than the traditional 96 or 384 reaction setup in a single run and the reaction volume was reduced from 20–50 μl down to 30–100 nl sized droplets. Combining one-step chemistry with the technology offered by the devices being developed would lead to a high-throughput RNA-to-signal system capable of reverse transcribing and performing PCR on thousands of nanolitre sized reactions every day. It is envisaged that this technology will also lead to gene expression from single cells contained in nanolitre sized droplets. In this paper, a study was conducted in which an extra thermal region, manufactured from aluminium, was added to the existing continuous flow instruments. This region was maintained at a temperature suitable for reverse transcription, which was 48°C for the one-step kit tested. The thermal region was also a suitable length to maintain the sample at the required temperature for 15 minutes. Using a commercially available one step RT-PCR kit (TaqMan® RNA-to-CT™ 1-Step Kit, 4392653), the device was evaluated for its potential to perform one-step RT-PCR in continuously flowing nanolitre sized droplets. Electrophoresis gels were initially used in assessing specific amplification before an end-point detection method was utilized. RNA was extracted from the leukemic REH cell line with the housekeeping gene, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) as the gene of interest. To investigate the possibility of further reducing sample preparation and facilitating further automation, amplification from cell lysates without nucleic acid extraction was carried out on the device. Cell lysates were prepared using the cell lysis buffer from the TaqMan® Gene Expression Cells-to-CT™ Kit (Cat #AM1728). It was found that the device was successful in one-step RT-PCR from extracted RNA samples and samples from cell lysates without nucleic acid extraction.
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Lugarà, R., S. Greve, S. Sinz, S. Marquardt, and K. Giller. "Effects of maternal and direct polyphenol intake on hepatic gene expression in lambs and kids." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_118.
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Nurjayadi, M., I. Santoso, I. R. Kartika, et al. "Isolation, amplification and characterization of foodborne pathogen disease bacteria gene for rapid kit test development." In INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES 2016 (ISCPMS 2016): Proceedings of the 2nd International Symposium on Current Progress in Mathematics and Sciences 2016. Author(s), 2017. http://dx.doi.org/10.1063/1.4991181.
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Brohawn, P. K., B. W. Higgs, S. Patel, A. Moody, P. Cooper, and K. Ranade. "AB1212 Analytical validation of an interferon-inducible gene expression kit as a potential diagnostic test for anifrolumab." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.2547.
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Schageman, Jeoffrey J., José Luis Costa, Orla Sheils, et al. "Abstract 1386: Clinical research results for a NGS-based kit for targeted detection of clinically relevant gene rearrangements in lung tumor samples." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1386.
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Rydén, L., I. Johansson, A. Ebbesson, et al. "P3-01-11: Increased Gene Copy Number of c-KIT and VEGFR2 at 4q12 in Primary Breast Cancer Is Related to an Aggressive Phenotype and Impaired Prognosis." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p3-01-11.
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"Increasing Intrinsic Motivation of Programming Students: Towards Fix and Play Educational Games." In InSITE 2018: Informing Science + IT Education Conferences: La Verne California. Informing Science Institute, 2018. http://dx.doi.org/10.28945/3996.
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Aim/Purpose: [This Proceedings paper was revised and published in the 2018 issue of the journal Issues in Informing Science and Information Technology, Volume 15] The objective of this research is to investigate the effectiveness of educational games on learning computer programming. In particular, we are focusing on examining whether allowing the players to manipulate the underlying code of the educational game will increase the intrinsic motivation of the programming students. Background: Traditionally, learning computer programming is considered challenging. Educational games can be used as a tool to motivate students to learn challenging subjects such as programming. Young students are fond of playing digital games. Moreover, they are also interested in creating game applications. Methodology: We created a prototype for a casual game to teach the fundamentals of conditional structures. Casual games, compared to other genres, are easy to learn and play. A number of errors were intentionally included in the game at different stages. Whenever an error is encountered, students have to stop the game and fix the bug before proceeding. In order to fix a bug, a student should understand the underlying program of the game. In this strategy, we believe that the self-esteem of the students will be built as they fix the bugs. This in turn will intrinsically motivate the students to actively engage in learning while playing. Contribution: Learning first programming language is considered very challenging. This research, investigates a novel approach to teach programming using educational games. Findings: A pilot study was conducted using the prototype to evaluate our claim. The outcome of the evaluation is encouraging. Allowing the gamers, who use educational games for learning programming, to manipulate the underlying code of the educational game will increase the intrinsic motivation of the programming students. This paper will describe the problem statement, research methodologies, preliminary results, and future directions of the research. Recommendations for Practitioners: Creating industry level educational games to teach programming will be beneficial to the society. Recommendation for Researchers: Learning first computer programming language is considered challenging. This research investigates a novel approach to teach programming. we focused on examining whether allowing the players to manipulate the underlying code of the educational game will increase the intrinsic motivation of the programming students. We used casual games for investigation. This research may be extended for other genres. Comparing this approach with other approaches such as Algorithm Animation techniques will be another potential research topic. Impact on Society: Today, digital technology plays a key role in our daily lives. Even the kids’ toys are becoming more and more digital and some of which are programmable. The future generations of students should be able to use digital technologies proficiently. In addition, they should also be able to understand and modify the underlying computer programs. Nevertheless, learning computer programming is considered challenging, and beginning students are easily frustrated and become bored. This research investigate a novel approach to alleviate this disenchantment. Future Research: In future, different types of casual games will be developed to learn different topics in computer programming, and a full scale evaluation (including objective evaluation using game scores) will be conducted. This research will follow the principles outlined in the US Department of Education’s Common Guidelines for Education and Research The reliability of the questionnaire will be measured using Cronbach’s alpha. One-way MANOVA will analyze the efficacy of the proposed intervention on the students’ performance, and their intrinsic motivation and flow experience. The sample sizes may be different. A priori analysis will be conducted to verify existence of multivariate outliers, normality condition, and homogeneity of covariance. Power and Effect size analysis will be reported