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Journal articles on the topic 'Knee osteoarthritis'
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Alvarez López, Alejandro. "Lateral Knee Osteoarthritis." Clinical Orthopaedics and Trauma Care 4, no. 1 (2022): 01–05. http://dx.doi.org/10.31579/2694-0248/017.
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Background: gonarthrosis is a common entity characterized by involvement of one or more compartments, of which the lateral one is the one with the lowest incidence in isolation. Aim: the aims of this research are too updated on the most important features on lateral knee osteoarthritis and look for updated bibliography on the subject. Methods: PubMed, Hinari, SciELO and Medline databases were searched for citations from August 1st 2021 to September 30th 2021 using the EndNote search manager and reference manager. Out of 312 articles, 44 selected citations were used in this review, being 42 of the last five years. Results: the main causes of lateral knee osteoarthritis are mentioned, especially the secondary ones. Reference is made to the main clinical and imaging elements for diagnosis based on plain radiography and magnetic resonance imaging. Both conservative and surgical treatment modalities are exposed, in the latter the main indications and complications are described, among which osteotomies and arthroplasties stand out. Conclusions: lateral gonarthrosis is the least common of the unicompartmental gonarthrosis that affect the knee joint. Clinical and imaging diagnosis provides the essential elements for both conservative and surgical therapeutic behaviour, the latter modality includes techniques that preserve the joint such as osteotomies and others that do not, such as arthroplasties.
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Fahlman, Lissa, Emmeline Sangeorzan, Nimisha Chheda, and Daphne Lambright. "Older Adults without Radiographic Knee Osteoarthritis: Knee Alignment and Knee Range of Motion." Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 7 (January 2014): CMAMD.S13009. http://dx.doi.org/10.4137/cmamd.s13009.
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This study describes knee alignment and active knee range of motion (ROM) in a community-based group of 78-year old adults (n = 143) who did not have radiographic evidence of knee osteoarthritis in either knee (KL < 2). Although knee malalignment is a risk factor for knee osteoarthritis, most women and men had either valgus or varus alignments. Notably, no men were valgus in both knees. Women with both knees valgus had significantly greater body mass index ( P > 0.001) than women with varus or straight knees. Men and women with valgus or varus knee alignments had generally lower ROM than individuals with both knees straight. In summary, this study highlights the complex relationships among knee alignment, ROM, body mass index, and gender in elderly adults without radiographic knee osteoarthritis.
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Brigham, Christopher R., Charles N. Brooks, and James B. Talmage. "Knee Osteoarthritis." Guides Newsletter 10, no. 2 (2005): 1–3. http://dx.doi.org/10.1001/amaguidesnewsletters.2005.marapr01.
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Abstract More than 20 million Americans have osteoarthritis (OA), which affects the knee more often than any other joint and is the most common cause of long-term disability in persons older than 65 years. Knee OA is common, particularly in older patients and especially the obese. Knee injury, depending on the severity and type, can increase the risk of developing and the rate of progression of OA. In assessing impairment for knee OA, the evaluator must obtain a thorough history and physical examination and identify all potential risk factors. To opine that an injury caused OA, the evaluator should demonstrate that the traumatized knee shows significant arthritis but that the contralateral uninjured knee is radiographically normal; for an evaluator to suggest that pre-existing arthritis was aggravated, the involved knee should show significantly more advanced OA than the contralateral joint. Joint space widths (cartilage intervals) of both knees must be measured carefully on anteroposterior films obtained standing with a film-to-camera distance of 90 cm (36 in) and the beam at the level of and parallel to the joint surface. Taking into account all of the data (history, physical findings, and radiographic measurements from both the involved and contralateral joint), the rating physician can assess causation, estimate impairment, and apportion the latter to one or more etiologies.
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Phalswal, Uma, Vandna Pandey, Ashok Kumar, and Abhay Elhence. "Correlation of knee society score and oxford knee score in patients with moderate to severe osteoarthritis of the knee." IP International Journal of Orthopaedic Rheumatology 7, no. 1 (2021): 17–23. http://dx.doi.org/10.18231/j.ijor.2021.005.
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Osteoarthritis (OA) of the knee is a degenerative, non-inflammatory joint condition marked by articular cartilage disintegration and the growth of new bone (osteophytes) at the joint surfaces and borders. It impairs one's ability to function and makes one disabled. It is the most common rheumatic disease. Because the Knee is a weight-bearing joint and a crutch joint, it is the most usually afflicted joint by Osteoarthritis.A Correlational study was conducted to find out the correlation between Knee Society Score (KSS) and Oxford Knee Score (OKS) on 142 Osteoarthritis Knees. Purposive sampling was used to collect data from the Orthopaedics OPD at AIIMS Jodhpur from October to December 2018.On evaluation, the mean age of the patients was 60.19±1.01. Bilateral Knee Osteoarthritis affected about 42% of the patients. Approximately half of the patients were obese. Only 34% of patients had compliance in physiotherapy. Analgesics and massage treatment are used by about 76% of the patients to relieve knee pain. In the Knee Society Score, the majority of the patients (82.4%) had a bad knee condition, with a mean score of 49.07±1.06. In OKS, about half of the patients (46.5%) had Moderate to Severe Knee Osteoarthritis, with a mean score of 22.69±7.09. The correlation coefficient between the Knee Society Score and the Oxford Knee Score is 0.660. As a consequence of the analysis, both scales have almost the same outcome, indicating that they are moderately associated. The Knee Society Score is highly associated with occupation and physiotherapy, whereas the Oxford Knee Score is significantly related to the patients' age alone. According to the study, there is a moderate correlation between the Knee Society Score (KSS) and the Oxford Knee Score (OKS). These scores should be included during the diagnosis of Knee Osteoarthritis for improved patient care.
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Bonanzinga, Tommaso, Pietro Conte, Giuseppe Anzillotti, et al. "Native intra-articular knee microbiome is a matter of facts: a systematic review of clinical evidence." EFORT Open Reviews 9, no. 10 (2024): 969–79. http://dx.doi.org/10.1530/eor-23-0191.
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Purpose Growing interest surrounds the role of human gut microbiome in the development of degenerative pathologies such as osteoarthritis (OA), but microbes have recently been detected also in other sites previously considered to be sterile. Evidence emerged suggesting that even native and osteoarthritic knee joints may host several microbial species possibly involved in the osteoarthritic degeneration. This is the first systematic review critically collecting all the available evidence on the existence and composition of knee intra-articular microbiome. Methods A systematic research on the PubMed, Cochrane and Google Scholar databases was performed. Human clinical studies investigating the presence of intra-articular microbiome in native osteoarthritic knee joints with next-generation sequencing techniques were collected. Results A total of eight studies were included reporting data on 255 knees. All the included studies reported evidence supporting the existence of an intra-articular microbiome in native knee joints, with detection rates varying from 5.8% to 100%. Bacteria from the Proteobacteria phylum were found to be among the most identified followed by the Actinobacteria, Firmicutes, Fusobacteria, and Bacteroideta phyla. Proteobacteria phylum were also found to be more common in osteoarthritic knees when compared to healthy joints. Furthermore, several pathways correlating those microbes to knee OA progression have been suggested and summarized in this review. Conclusions Evidence collected in this systematic review suggests that the native knee joint, previously presumed to be a sterile environment, hosts a peculiar intra-articular microbiome with a unique composition. Furthermore, its alteration may have a link with the progression of knee osteoarthritis.
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Butarbutar, John, Mirna Phandu, Kevin Lee, Earlene Tasya, and Wendell Sebastian Sulaeman. "Ultrasound-guided Genicular Nerve Ablation with Alcohol Solution for Knee Osteoarthritis: A Case Series." Medicinus 11, no. 2 (2023): 69. http://dx.doi.org/10.19166/med.v11i2.7531.
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<div class="WordSection1"><p>Genicular nerve ablation using radiofrequency (RF) is a common minimally invasive procedure for painful osteoarthritic knees. However, the high cost and unavailability of equipment in many healthcare centers made this inconvenient for some patients. Some case reports tried the cheaper and newer method, using an alcohol solution to ablate the genicular nerves, showing considerable improvement in the patient's pain, functional knee score, and quality of life. We have attempted the ultrasound-guided genicular nerve ablation using alcohol solution in 6 patients with knee osteoarthritis to complement the body of evidence. We found that the genicular nerve ablation using alcohol solution is an excellent method for relieving symptoms of knee osteoarthritis if knee pain is the main symptom.</p></div>
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Yadav, Gopal, Divesh Singh, and Abhinav Yadav. "Knee Varus as "Pre - Osteoarthritic Lesion" in Initiation and Progression of Knee Osteoarthritis in Perimenopausal Women." International Journal of Science and Research (IJSR) 13, no. 8 (2024): 712–16. http://dx.doi.org/10.21275/sr24809153454.
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Shapiro, Shane A., Jennifer R. Arthurs, Michael G. Heckman, et al. "Quantitative T2 MRI Mapping and 12-Month Follow-up in a Randomized, Blinded, Placebo Controlled Trial of Bone Marrow Aspiration and Concentration for Osteoarthritis of the Knees." CARTILAGE 10, no. 4 (2018): 432–43. http://dx.doi.org/10.1177/1947603518796142.
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ObjectiveBone marrow aspiration and concentration (BMAC) is becoming a more common regenerative therapy for musculoskeletal pathology. In our current pilot study, we studied patients with mild-to-moderate bilateral knee osteoarthritis, compared pain at 12-month follow-up between BMAC-injected and saline-injected knees, and examined cartilage appearance measured by magnetic resonance imaging (MRI) T2 quantitative mapping.DesignTwenty-five patients with mild-to-moderate bilateral osteoarthritic knee pain were randomized to receive BMAC into one knee and saline placebo into the other. Bone marrow was aspirated from the iliac crests, concentrated in an automated centrifuge, combined with platelet-poor plasma for knee injection, and compared with saline injection into the contralateral knee. Primary outcome measures were T2 MRI cartilage mapping at 6-month and Visual Analog Scale and Osteoarthritis Research Society International Intermittent and Constant Osteoarthritis Pain scores and radiographs at 12-month follow-up.ResultsConstant, intermittent, and overall knee pain remained significantly decreased from baseline at 12-month follow-up (all P ⩽ 0.01), with no apparent difference between BMAC- and saline-treated knees (all P ⩾ 0.54). A similar significant increase from baseline to 12-month follow-up regarding quality of life was observed for both BMAC- and saline-treated knees (all P ⩽ 0.04). T2 quantitative MRI mapping showed no significant changes as a result of treatment.ConclusionsBMAC is safe to perform and relieves pain from knee arthritis but showed no superiority to saline injection at 12-month follow-up. MRI cartilage sequences failed to show regenerative benefit with single BMAC injection. The mechanisms of action that led to pain relief remain unclear and warrant further studies.
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Abbas, Nauman, Sabir Khattak, Muhammad Umer Faheem, Naeem Ahmed Shah, Amer Aziz, and Latif Khan. "SAFE ZONE OF JOINT LINE ELEVATION FOR THE TREATMENT OF KNEE FLEXION CONTRACTURE PREVENTING MID-FLEXION INSTABILITY IN TOTAL KNEE REPLACEMENT." Journal of Ayub Medical College Abbottabad 36, no. 2 (2024): 234–39. https://doi.org/10.55519/jamc-02-13141.
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Background: In osteoarthritic knee, flexion deformity is caused by synovial inflammation, posterior femoral and tibial osteophytes tenting onto the capsule, ligamentous contracture and hamstring shortening. This study aimed to evaluate the safe zone of joint line elevation for the treatment of flexion knee contracture preventing mid-flexion instability in total knee replacement. Methods 51 knees with varus osteoarthritis undergoing TKA were evaluated. 39 knees with flexion contracture < 15°and 12 knees with flexion contracture >15°. 2-mm joint line elevation was performed in just 4 knees with >15° flexion contracture. The extension and flexion gaps were measured with traditional spacer block. Stability in coronal plane (varus & valgus stress) was assessed at 0,30,60 & 90 degrees. Sampling Technique was non probability consecutive. SPSS 23 was used for statistical analysis. Results: The study comprises 51 patients undergoing total knee replacement (TKA) for osteoarthritis, with a notable gender distribution (84.3% women, 15.7% men) and a mean age of 60.24±8.54 years. Of these, 41.2% had both knees affected, and joint elevation was performed in 23.5% with flexion contracture >15°. No instability was found in cases with joint line elevation. Flexion contracture analysis revealed asymmetry across sides, yet no statistically significant differences. Detailed comparisons show variability in flexion contracture and range of motion, emphasizing the complexity of side-specific outcomes. The study underscores the importance of tailored evaluation and intervention for flexion contracture >15° to optimize postoperative results. Conclusions This study has shown that in patients with varus osteoarthritis of the knee and flexion contracture > 15°, a 2-mm joint line elevation is safe to treat knee flexion contracture and is not associated with mid-flexion laxity. Level of evidence IV Cross sectional study.
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Lopresti, Adrian L., Stephen J. Smith, Shavon Jackson-Michel, and Timothy Fairchild. "An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study." Nutrients 14, no. 1 (2021): 41. http://dx.doi.org/10.3390/nu14010041.
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Curcumin, a phytochemical from the spice turmeric, has anti-inflammatory properties and has been shown to have pain-relieving effects. In this 8-week, randomised, double-blind, placebo-controlled study, 101 adults with knee osteoarthritis received either 500 mg twice daily of a standardised curcumin extract (Curcugen®) or placebo. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score (KOOS), knee pain ratings, Japanese Orthopaedic Association Score for Osteoarthritic Knees (JOA), PROMIS–29, and performance-based testing comprising the 40-m fast-paced walk test, 6-min walk test, timed up-and-go test, and 30-s chair stand test. Compared to the placebo, curcumin significantly reduced the KOOS knee pain score (p = 0.009) and numeric knee pain ratings (p = 0.001). Curcumin was also associated with greater improvements (p ≤ 0.05) than the placebo on the timed up-and-go test, 6-min walk test, and the JOA total score; but not the 30-s chair stand test or 40-m fast-paced walk test. Pain-relieving medication was reduced in 37% of participants on curcumin compared to 13% on placebo. The findings support the potential efficacy of curcumin for the treatment of osteoarthritis of the knee but studies of longer duration, varying treatment doses, differing curcumin extracts, and the use of other objective outcome measures will be helpful to expand on these findings.
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Ozaki, Yusuke, Ryota Hara, Kensuke Okamura, et al. "Correlation between varus-type knee osteoarthritis severity and hindfoot alignment: Analysis of radiographs in the long-leg weight-bearing anteroposterior view." PLOS One 20, no. 6 (2025): e0324974. https://doi.org/10.1371/journal.pone.0324974.
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Background In knee osteoarthritis, the subtalar joint undergoes valgus and varus contractions to compensate for deformities in the knee joint. In this cross-sectional study, we investigated the relationship between varus-type knee osteoarthritis severity and hindfoot alignment severity by concurrently assessing varus-type knee osteoarthritis severity and hindfoot alignment using radiographs in the long-leg weight-bearing anteroposterior view. Patients and methods A total of 114 patients with knee osteoarthritis graded Kellgren–Lawrence II or higher (128 knees) and 30 healthy controls (31 knees) underwent long-leg weight-bearing anteroposterior imaging for 1 year. Four angles were measured on radiographs in the long-leg weight-bearing anteroposterior view: the femorotibial angle; tibial calcaneal angle; tibial anterior surface angle; and talocrural joint angle between the tibial plafond and talar dome on weight-bearing. Group comparisons were conducted for each Kellgren–Lawrence classification, which was used to classify the severity of knee osteoarthritis at each measured angle. One-way analysis of variance was used to test the results. Results The mean tibial calcaneal angles were 9.7°, 11.3°, 8.8°, and 9.8° in controls and in patients with Kellgren–Lawrence grades II, III, and IV, respectively (p < 0.05). The mean femorotibial angles were 175.6°, 176.8°, 180.3°, and 186.2° in controls and in patients with Kellgren–Lawrence grades II, III, and IV, respectively (p < 0.05). On weight-bearing, the tibial anterior surface angle and the talocrural joint angle between the tibial plafond and talar dome varied according to severity level. Conclusion In varus-type knee osteoarthritis cases, defined in accordance with the Kellgren–Lawrence classification, hindfoot alignment leaned toward valgus. As the severity of knee osteoarthritis progressed, the valgus of the hindfoot alignment reduced. While future longitudinal analyses are necessary, these observations indicate both potential compensatory changes and their limitations in varus-type knee osteoarthritis.
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Lobenhoffer, Philipp. "Indication for Unicompartmental Knee Replacement versus Osteotomy around the Knee." Journal of Knee Surgery 30, no. 08 (2017): 769–73. http://dx.doi.org/10.1055/s-0037-1605558.
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AbstractUnicompartmental medial or lateral osteoarthritis of the knee is found in up to 50% of all osteoarthritic patients and may be addressed surgically either by knee osteotomies or unicompartmental replacements. The limits for indicating one procedure or the other are somehow not defined. This article discusses the diagnostic algorithm and the most important decision factors. A long-leg radiograph and formal deformity analysis is mandatory. If constitutional or posttraumatic metaphyseal deformity in the frontal plane is detected and the opposite compartment is intact, an osteotomy should be considered. The result is not depending on age and grade of osteoarthritis. Unicompartmental knee arthroplasty is indicated in substantial osteoarthritis of one compartment (bone-on-bone) with intact ligaments and a functionally intact contralateral compartment. The anatomy of the femur and tibia should be normal with no gross osseous deformity. Age, obesity, or asymptomatic patellofemoral degeneration are not considered exclusion criteria for those surgical procedures.
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Oguzie, C. G., O. A. Lasebikan, C. J. Onyempka, et al. "Cause and Effect Relationship of Body Weight and Knee Osteoarthritis: Experience from a Tertiary Institution in South-Eastern Nigeria." Journal of BioMedical Research and Clinical Practice 2, no. 1 (2019): 9–13. http://dx.doi.org/10.46912/jbrcp.93.
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It is well established that obesity is related to osteoarthritis of the knees. The aim of this study was to investigate the risk of knee osteoarthritis in relation to body mass index (BMI) and specifically, to assess the risk of knee osteoarthritis (OA) attributable to obesity. We also aimed to determine if there is a higher risk with an increase in BMI. This is an observational case-referent study of patients with knee pain. Patients were recruited from the orthopaedics clinic. The cases were patients that presented with radiologically diagnosed knee osteoarthritis, while the referents were other patients that also attended the orthopedic clinic at the same time. The referents were randomly selected. Body Mass Index was calculated and classified based on the WHO international classification. Data were analyzed using SPSS version 21. A total of 152 patients were included in the study and 67.1% were females while 32.9% were males giving a ratio of 2:1. The mean age was 57.72+/-12.5 years, the mean weight was 79.47+/- 13.41kg (95% CI 77.32 – 81.62) and the mean BMI was 27.80+/-6.2kg/m2. 56.6% had knee osteoarthritis. 8.6% (n = 13) were bilateral, 18.4% (n = 28) in the left knee and 29.6% (n = 45) in the right knee. The relationship between obesity and the presence of knee osteoarthritis was statistically significant (p 0.047). A Chi-squared test for trend also did not show an increased risk for knee osteoarthritis with increasing BMI (p 0.105). In conclusion, knee osteoarthritis is a degenerative joint disease that mostly affects the elderly. Our findings give strong support to the already existing knowledge of the positive relationship between obesity and knee osteoarthritis; however, increasing BMI did not increase the risk of knee OA.
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Ogawa, Ami, Hirotaka Iijima, and Masaki Takahashi. "Identification of Early Knee Osteoarthritis Based on Knee Joint Trajectory during Stair Climbing." International Journal of Environmental Research and Public Health 19, no. 22 (2022): 15023. http://dx.doi.org/10.3390/ijerph192215023.
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Patients with knee osteoarthritis show low stair climbing ability, but a diagnosis of stair performance time is not enough to identify the early stages of knee osteoarthritis. Therefore, we developed an indicator named range of the knee joint trajectory (RKJT) as a kinematic parameter to express more detailed characteristics than stair performance time. To achieve this, we used our developed “IR-Locomotion”, a markerless measurement system that can track the knee joint trajectory when climbing stairs. This study aimed to test whether the RKJT effectively identifies patients with early knee osteoarthritis even after controlling stair performance time. Forty-seven adults with moderate to severe knee pain (mean age 59.2 years; 68.1% women) underwent the radiographic examination (Kellgren and Lawrence grade) of both knees and a stair climbing test on 11 stairs. The RKJT during the stair climbing test was calculated by “IR-Locomotion”. A generalized linear mixed model was used to evaluate the discriminative capability of RKJT on early knee osteoarthritis (i.e., Kellgren and Lawrence grade of 1). As expected, patients with early knee osteoarthritis showed larger RKJT than non-radiographic controls (95% confidence interval: 1.007, 1.076). Notably, this finding was consistent even after adjusting stair performance time.
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Hálfdanardóttir, Freyja, Dan K. Ramsey, and Kristín Briem. "Timing of Frontal Plane Trunk Lean, Not Magnitude, Mediates Frontal Plane Knee Joint Loading in Patients with Moderate Medial Knee Osteoarthritis." Advances in Orthopedics 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/4526872.
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The purpose of this study was to examine the influence of trunk lean and contralateral hip abductor strength on the peak knee adduction moment (KAM) and rate of loading in persons with moderate medial knee osteoarthritis. Thirty-one males (17 with osteoarthritis, 14 controls) underwent 3-dimensional motion analysis, strength testing of hip abductors, and knee range of motion (ROM) measures, as well as completing the knee osteoarthritis outcome score (KOOS). No differences were found between groups or limbs for gait cycle duration, but the osteoarthritis group had longer double-limb support during weight acceptance (p<0.001) and delayed frontal plane trunk motion towards the stance limb (p<0.01). This was reflected by a lower rate of loading for the osteoarthritis group compared to controls (p<0.001), whereas no differences were found for peak KAM. Trunk angle, contralateral hip abductor strength, and BMI explained the rate of loading at the involved knee (p<0.001), an association not found for the contralateral knee or control knees. Prolonged trunk lean over the stance limb may help lower peak KAM values. Rate of frontal plane knee joint loading may partly be mediated by the contralateral limb’s abductor strength, accentuating the importance of bilateral lower limb strength for persons with knee osteoarthritis.
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P. K., Navaneeth, Prakash Nayar S., and T. M. Jose. "Clinical and functional outcome of total knee arthroplasty in osteoarthritic patients at a tertiary care center in Kerala: a prospective study." International Journal of Advances in Medicine 9, no. 10 (2022): 1017. http://dx.doi.org/10.18203/2349-3933.ijam20222399.
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Background: Osteoarthritis affects the knee joint more frequently than any other joint. Osteoarthritis is a chronic joint disease that affects the older age group, women more frequently, and is associated in 90% of cases with a varus deformity of the knee. The following study was conducted to evaluate the functional outcome of total knee arthroplasty in osteoarthritis using the knee society score.Methods: The study was conducted in patients treated for osteoarthritis of the knee joint at Jubilee Mission Medical College and Research Institute, Thrissur, Kerala during the period from December 2019 to March 2022. Thirty patients diagnosed with osteoarthritis of the knee joint were taken into the study, all were undergone total knee arthroplasty. Patients were followed up at 4 weeks, 12 weeks, and 24 weeks.Results: The sample consisted of thirty osteoarthritic patients with 8 males and 22 were females. The patients' ages ranged from 45-75 years. Among these 30 patients, 14 involved the right side, and 16 involved the left knee joint. The mean pre-operative knee clinical score was 36.93 which was improved to post-operative 84.70 following total knee arthroplasty. The mean pre-operative knee functional score was 16.83 which was improved to post-operative 71.17 following total knee arthroplasty. The outcome was rated as per knee society score. We got excellent results in 25 cases (83%), good in 3 (10%), and fair in 2 patients (7%) according to knee clinical score whereas 8 excellent (27%), 16 good (53%), 5 fair (17%) and 1 poor (3%) results were found according to knee functional score.Conclusions: Total knee arthroplasty shows drastic improvement in the functional ability of the patient and the ability of the patient to get back to a pre-disease state, which is mainly because of pain-free joint movements, reflected by the improvement in the post-operative knee clinical score and knee functional score.
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Vad, Vijay B., David R. Adin, and Jennifer Solomon. "Knee Osteoarthritis." Critical Reviews in Physical and Rehabilitation Medicine 16, no. 3 (2004): 211–32. http://dx.doi.org/10.1615/critrevphysrehabilmed.v16.i3.30.
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Cho, Eiji. "Knee Osteoarthritis." Journal of Nihon University Medical Association 72, no. 2 (2013): 77–80. http://dx.doi.org/10.4264/numa.72.77.
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Benner, Rodney W., K. Donald Shelbourne, Scot N. Bauman, Adam Norris, and Tinker Gray. "Knee Osteoarthritis." Orthopedic Clinics of North America 50, no. 4 (2019): 425–32. http://dx.doi.org/10.1016/j.ocl.2019.05.001.
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Brauer, Sandra. "Knee osteoarthritis." Journal of Physiotherapy 61, no. 2 (2015): 100. http://dx.doi.org/10.1016/j.jphys.2015.02.018.
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Nazari, Goris. "Knee osteoarthritis." Journal of Physiotherapy 63, no. 3 (2017): 188. http://dx.doi.org/10.1016/j.jphys.2017.04.004.
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Sharma, Leena, Jing Song, Dorothy Dunlop, et al. "Varus and valgus alignment and incident and progressive knee osteoarthritis." Annals of the Rheumatic Diseases 69, no. 11 (2010): 1940–45. http://dx.doi.org/10.1136/ard.2010.129742.
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ObjectiveVarus and valgus alignment increase medial and lateral tibiofemoral load. Alignment was associated with tibiofemoral osteoarthritis progression in previous studies; an effect on incident osteoarthritis risk is less certain. This study tested whether alignment influences the risk of incident and progressive radiographic tibiofemoral osteoarthritis.MethodsIn an observational, longitudinal study of the Multicenter Osteoarthritis Study cohort, full-limb x-rays to measure alignment were acquired at baseline and knee x-rays were acquired at baseline and knee x-rays at baseline and 30 months. Varus alignment was defined as ≤178° and valgus ≥182°. Using logistic regression and generalised estimating equations, the associations of baseline alignment and incident osteoarthritis at 30 months (in knees without baseline osteoarthritis) and alignment and osteoarthritis progression (in knees with osteoarthritis) were examined, adjusting. For age, gender, body mass index, injury, laxity and strength, with neutral knees as referent.Results2958 knees (1752 participants) were without osteoarthritis at baseline. Varus (adjusted OR 1.49, 95% CI 1.06 to 2.10) but not valgus alignment was associated with incident osteoarthritis. 1307 knees (950 participants) had osteoarthritis at baseline. Varus alignment was associated with a greater risk of medial osteoarthritis progression (adjusted OR 3.59, 95% CI 2.62 to 4.92) and a reduced risk of lateral progression, and valgus with a greater risk of lateral progression (adjusted OR 4.85, 95% CI 3.17 to 7.42) and a reduced risk of medial progression.ConclusionVarus but not valgus alignment increased the risk of incident tibiofemoral osteoarthritis. In knees with osteoarthritis, varus and valgus alignment each increased the risk of progression in the biomechanically stressed compartment.
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Witjes, Suzanne, Alexander Hoorntje, Koen L. M. Koenraadt, Gino M. M. J. Kerkhoffs, and Rutger C. I. van Geenen. "Higher Function Scores and Satisfaction in Patients with Anteromedial Osteoarthritis Compared with Other Wear Patterns of the Knee: 2 Years after Both Total and Unicondylar Knee Arthroplasties." Journal of Knee Surgery 33, no. 07 (2019): 629–35. http://dx.doi.org/10.1055/s-0039-1683925.
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AbstractAnteromedial osteoarthritis (AMOA) is a common wear pattern in primary osteoarthritic knees. In patients with bone-on-bone disease, the most appropriate surgical intervention is still a matter of debate. Knee arthroplasty is a well-accepted treatment to relieve symptoms and regain function. Unfortunately, satisfaction is limited, especially related to activities. A cross-sectional study was performed among patients treated with total knee arthroplasty (TKA) and unicondylar arthroplasty (UKA) to determine if the osteoarthritis wear pattern or type of prosthesis affects knee-specific function scores and satisfaction related to activities. All UKA patients (N = 100) were treated for AMOA. Based on radiological assessment of the wear pattern, TKA patients were divided into two groups: TKA for AMOA (N = 68) and true TKA (N = 99). The Knee injury and Osteoarthritis Outcomes Score (KOOS), new Knee Society score (KSS), anterior knee pain scale, visual analog scales (VASs) for satisfaction about activities, and net promoter score were collected. After 2 years' follow-up, the anterior knee pain scale and VAS satisfaction showed significantly better scores for patients treated with TKA for AMOA compared with the true TKA group. Also in the KOOS subscales, some differences were seen in favor of the TKA for AMOA group. The new KSS was not in favor of a specific wear pattern, but patients with AMOA treated with UKA performed better on the symptoms subscale compared with patients treated with TKA. In conclusion, patients treated with TKA for AMOA showed better knee-specific function scores and satisfaction scores compared with patients treated with TKA for other wear patterns, and only slight differences were found between both the AMOA groups (TKA for AMOA and UKA). Thus, the radiologic assessment of wear patterns might be useful to take into account the shared decision-making process, when discussing expectations, timing, and outcomes with knee osteoarthritis patients considering knee arthroplasty. When AMOA is present, it might be beneficial to choose UKA over TKA.
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Warman, Fanny Indra. "CORRELATION REALIGNMENT MECHANICAL TIBIOFEMORAL ANGLE WITH CLINICAL OUTCOME ON PATIENTS KNEE OSTEOARTHRITIS VALGUS DEFORMITY PERFOREMED TOTAL KNEE ARTHROPLASTY AT PROF. DR. R. SOEHARSO ORTHOPAEDIC HOSPITAL SURAKARTA (JANUARY 2019 - DECEMBER 2019)." Hip and Knee Journal 3, no. 2 (2022): 64–70. http://dx.doi.org/10.46355/hipknee.v3i2.130.
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Background : Knee osteoarthritis (OA) is important because of the high prevalence of pain and disability in older adults.Angular deformities around the knee joint necessitate special consideration to restore normal alignment during TKA. Excessive preoperative malalignment predisposes to a greater risk of failure compared to well-aligned knees. In Ranawat grade-III the axis deviation is more than 20°. All the medial stabilizing elements are typically not functional so a constrained implant usually is required.The aim of this research to savvy correlation realignment mechanical tibiofemoral angle with clinical outcome on patients knee osteoarthritis valgus deformity performed TKA with non-constrained imlpant. Methods : This research is an analytics observational with cross sectional that group patients knee osteoarthritis valgus devormity underwent total knee arthroplasty and performed correlation realignment tibiofemoral angle as well as clinical outome. This research with total sampling method on patients knee osteoarthritis valgus deformity Kellgren-Lawrence grade III–IV, have radiological knee x-ray and lower extremity scanogram underwent TKA one side by orthopaedic surgeon sub adult reconstruction at Prof. Dr. R. Soeharso orthopaedic hospital Surakarta on periode January 2019 until Desember 2019. Evaluation has performed to pain scale used Visual Analog Scale (VAS) score, clinical outcome with Knee Society Score (KSS), realigment mechanical tibiofemoral angle before and after TKA. Data were analyzed using t-test and correlation test with SPSS version 16.Results : Analyzed 28 (male 6, female 22) patients with a mean age 65,75 years, which divided into three group Ranawat grade I was 14 patients, grade II was 9 patients and III was 5 patients. They were evaluated by VAS score, KSS score, mechanical tibiofemoral angle before and after TKA. Evaluated for VAS score, KSS objective and functional, mechanical tibiofemoral angle have significant result (P 0,05). There was also significantly correlation between improvement mechanical tibiofemoral angle with KSS knee score based value (P 0,05)Conclusion : In this study we found that TKA with non-constrained implant on knee osteoarthrits valgus deformity provides significant result in reducing pain scale and increased clinical outome.
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Ekinci, Mehmet, Turgut Akgül, Ufuk Arzu, Serkan Bayram, Taha Furkan Yağcı, and Önder Kılıçoğlu. "Anatomical bone structure differences in patients with hemophilic arthropathy of the knee." Journal of Clinical Imaging Science 12 (August 8, 2022): 46. http://dx.doi.org/10.25259/jcis_59_2022.
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Objectives: The anatomical differences of the bony structure of the knee joint in patients with hemophilia were evaluated, and the results were compared with the knees of patients with primary gonarthrosis and no arthrosis. Material and Methods: This study reviewed 41 knees in 21 patients (with an Arnold-Hilgartner classification of Stages 4 and 5 hemophilic arthropathy) who underwent total knee arthroplasty in single center. Two control groups including 21 asymptomatic patients (42 knees) and 21 primary knee osteoarthritis patients (42 knees) were formed to compare the measurements with hemophiliacs. Femoral mediolateral width, femoral anteroposterior width, femur and tibia diaphysis width, adductor tubercle-joint line distance, tibial plateau width, and medial and lateral tibia plateau width were measured separately. Results: Femoral mediolateral width was significantly narrow comparing with healthy individuals and primary knee osteoarthritis group. Tibial plateau was similar to asymptomatic group but significantly narrow compared with primary knee osteoarthritis group. With the correlation, the tibial plateau measurements and medial and lateral plateau were significantly narrow at hemophilic arthropathy group (P < 0.05). The slope was less in hemophilic patients as compared with asymptomatic individuals (P: 0.001). Hemophilic patients had larger femoral aspect ratios than asymptomatic group but there were no observable differences with the primary osteoarthritis group. For the tibial aspect ratios, hemophilic had a smaller ratio than the primary osteoarthritis group but there were no significant differences with the asymptomatic group. Conclusion: Hemophilic knee has a mismatch between femoral and tibial side while comparing with the other groups. Level of Evidence: Level IV, cross-sectional study.
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Singh, Poonam. "Integrated Management of Knee Osteoarthritis Associated Hypertension with Naturopathy and Yoga: A Case Report." International Research Journal of Ayurveda & Yoga 05, no. 10 (2022): 62–69. http://dx.doi.org/10.47223/irjay.2022.51009.
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Osteoarthritis of the Knees (OA Knees) also known as degenerative arthritis or degenerative joint disease is a group of mechanical abnormalities involving the degradation of joints, including articular cartilage and subchondral bone. Associated comorbid conditions such as hypertension increase the symptoms. Allopathic drugs taken to relieve the symptoms have their own side effects. The aim of treatment with naturopathy, yoga, and diet therapy is the reduction of symptoms and an increase in functional activities of patients with osteoarthritis of the knees. Naturopathy and therapeutic yogic exercises reduce pain, improve the strength of the joints, and support muscles and ligaments which provides good flexibility of the joints, and increases the range of motion. Diet plays a major role to prevent and control degeneration. A Vitamin D-rich diet helps to regenerate the joint wear and prevents worsening of the knee symptoms. Osteoarthritis may lead to early disability condition which needs to be managed as soon as possible. Osteoarthritic management requires a holistic approach.
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Dr., Mohammed Atif, Varun Maurya.R Dr., and S.Udhayaprakash Dr. "Retro-Prospective, Observational Study to Assess the Functional Ability in PatientsWho Underwent Total Knee Arthroplasty for Osteoarthritis." Retro-Prospective, Observational Study to Assess the Functional Ability in PatientsWho Underwent Total Knee Arthroplasty for Osteoarthritis 8, no. 12 (2023): 4. https://doi.org/10.5281/zenodo.10362387.
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Background Osteoarthritis is the most common joint disease in India, affecting 22% to 39% of the population. Compared to men, women are more prone to have OA, and as they age, this prevalence increases dramatically. In terms of nonfatal burden, OA was ranked as the tenth most common cause. Osteoarthritis is believed to be brought on by mechanical stress on the joint and low-grade inflammatory processes. Given the prevalence of knee arthritis, total knee arthroplasty (TKA) is one of the most common orthopaedic surgeries carried out globally. We evaluated the patients' functional recovery and result following total knee arthroplasty, taking into account their range of motion, independence in climbing stairs, and ability to kneel. Methods Evaluation of post-TKA patients' functional abilities using the Insall Knee Score, Oxford Knee Score, range of motion, and independent stair climbing ability in patients with osteoarthritis who had TKA. 46 patients, ages 45 to 80 years, of both sexes, were brought to the Annapoorana Medical College Hospital in Salem with advanced osteoarthritis in their knee joints; these individuals had total knee arthroplasty as treatment. This observational study is retro-prospective and was conducted from May 2021 to October 2023, with a follow-up period of two years. Results After a total knee replacement for osteoarthritis, the patient's functional status significantly improves, with the capacity to carry out everyday tasks being the ultimate objective. This dissertation validates it once more. We find that during the one-year post-operative follow-up period, there was a significant improvement in the functional outcome indicated by the Insall knee score, range of motion, and capacity to climb stairs independently. Nevertheless, the patient's ability to kneel was not observed to have improved. Despite their simplicity, knee movements are involved in a wide range of complex circumstances, each of which needs its own independent study. This could contribute to improved knee arthroplasty patient prognosis. Keywords:- Osteoarthritis, Total Knee Arthroplasty(TKA), Insall Knee Score, Kneeling.
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Dhanalakshmi.V., P. Padmavathi Dr., K. Chandramathi, Josphin S. Prema, and Revathi R. "A Study to Assess the Effectiveness of Clay Therapy on Physical Function among Patients with Knee Osteoarthritis in Selected Hospitals, Erode." International Journal of Innovative Science and Research Technology (IJISRT) 10, no. 1 (2025): 2421–27. https://doi.org/10.5281/zenodo.14874182.
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Background: About 10% of adults over 60 suffer from knee osteoarthritis (OA), one of the most prevalent types of arthritis is Knee osteoarthritis, with a prevalence of 22% to 39% in India, osteoarthritis is the most prevalent joint disease and the most common rheumatological issue. An alternate method of treating rheumatic conditions is mud pack therapy. Its foundation is the application of heated mud packs to the body as a whole or to particular regions, like the joints. The current study's objective was to assess the effectiveness of treatment using on physical function among patients with knee osteoarthritis. Design: Quasi experimental-non-equivalent control group pre and post-test design was selected for the study. Purposive sampling technique was used in this study. Samples included in this study were both genders with Knee osteoarthritis,30 years and above, and Stage 2, 3 & 4 Knee Osteoarthritis Standardized tool(WOMAC Scale )was used to assess the level of physical function among patients with knee osteoarthritis. Results: The study's results indicate that, for the level of physical function assessment scale, the overall area-wise comparison between the experimental and control post-test mean percentage difference was 43%.The experimental group's pre and post test scores for patients with osteoarthritis in their knees showed highly significant variations.. Paired t test value (t=47.97, t=33.96) was higher than the table value (t=4.14) at the level of significant (P<0.0001). Conclusion: Mud therapy was effective in improving the physical function among knee osteoarthritis patients, as used by WOMAC score scale.
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Dragosloveanu, Serban, Bogdan-Sorin Capitanu, Radu Josanu, Diana Vulpe, Romica Cergan, and Cristian Scheau. "Radiological Assessment of Coronal Plane Alignment of the Knee Phenotypes in the Romanian Population." Journal of Clinical Medicine 13, no. 14 (2024): 4223. http://dx.doi.org/10.3390/jcm13144223.
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Background: The Coronal Plane Alignment of the Knee (CPAK) classification system has been developed as a comprehensive framework delineating nine coronal plane phenotypes, based on arithmetic hip–knee angle (aHKA) and joint line obliquity (JLO). Our study aimed to assess the prevalence of knee phenotypes in the Romanian population using the CPAK classification, encompassing both osteoarthritic and healthy cohorts. Methods: We conducted an observational cross-sectional study, analyzing data from 500 knees with osteoarthritis and 500 healthy knees that met the inclusion criteria. Demographic data were collected, and radiological parameters including lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), aHKA, and JLO were measured. Knee phenotypes were categorized using the CPAK classification. Results: In the osteoarthritic cohort, the most prevalent CPAK phenotype was type I (42.4%), characterized by varus alignment and an apex distal joint. Conversely, in the healthy population, CPAK type II, indicating neutral alignment and an apex distal joint, was the most prevalent phenotype (39.0%). CPAK types VII, VIII, and IX were rare. Conclusions: Our findings demonstrate similarities in knee phenotypes compared to other populations, with some minor differences and particularities. The CPAK classification proves to be a valuable tool in assessing knee tyalignment.
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Fawthrop, Fiona, Janet Cushnaghan, Lily Shue, and Paul Dieppe. "Varus and Valgus Deformities of the Knee Joint: Disease Specific or Biomechanical?" Engineering in Medicine 15, no. 2 (1986): 87–88. http://dx.doi.org/10.1243/emed_jour_1986_015_024_02.
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160 patients (231 knees) with an angulation deformity of the knee have been examined. Varus deformity was uncommon except in patients with osteoarthritis. Osteoarthritis subsets, such as pyrophosphate arthropathy tend to cause a valgus deformity, as does rheumatoid disease. An analysis of 50 consecutive patients presenting with idiopathic knee osteoarthritis supports the impression that focal disease of the medial (common) or lateral (uncommon) compartment can occur. Different disease processes, with different associations, may be responsible. The biomechanics of the knee joint in relation to the development of angulation deformities is discussed.
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Hunter, David J., Jingbo Niu, Yuqing Zhang, et al. "Knee height, knee pain, and knee osteoarthritis: The Beijing Osteoarthritis Study." Arthritis & Rheumatism 52, no. 5 (2005): 1418–23. http://dx.doi.org/10.1002/art.21017.
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Mersiha Cerkezovic, Denijal Tulumović, Selmira Brkić, and Elvedin Osmanovic. "The association of osteoarthritis with metabolic disorders." Magna Scientia Advanced Research and Reviews 12, no. 1 (2024): 110–21. http://dx.doi.org/10.30574/msarr.2024.12.1.0158.
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Osteoarthritis (OA) is the most common form of synovial joint arthritis that causes chronic pain and disability to a large number of people worldwide. Most often, osteoarthritis affects the joints of the knees, hips, spine and hands. The Global Burden of Disease (GBD, 2021) estimates that osteoarthritis will be the fourth leading cause of disability by 2030, with enormous healthcare costs for treatment, as well as significant indirect costs due to loss of productivity and premature retirement. The aim of our research is to determine in what way prevalent metabolic syndrome is among participants with osteoarthritis of one of the synovial joints (knees, hips, hands), and whether metabolic disorders are a risk factor for the development and worsening of osteoarthritis. A prospective clinical study was conducted at the Public Health Institution Health Center Živinice, from July 2022 to May 2024, on a random sample of 200 participants with a confirmed clinical diagnosis of osteoarthritis (OA), who were divided into a group with metabolic syndrome and a group without metabolic syndrome based on the NCEP ATP III panel criteria for metabolic syndrome. The prevalence of knee osteoarthritis is significantly higher compared to the prevalence of hip and hand osteoarthritis, and it is greater among participants with a higher BMI (in participants with the highest BMI, knee osteoarthritis occurs with a 100% probability) and with the presence of metabolic syndrome, especially in more severe forms, specifically radiologically confirmed osteoarthritis, regardless of age and gender. Unlike OA knees the prevalence of OA hips and hands shows no correlation with BMI and metabolic syndrome. Multiple comparative analysis of differences in the average severity of osteoarthritis of the knee of subjects with normal glycemia / prediabetes / diabetes type 2 it showed a statistically significant difference in the average severity of knee osteoarthritis in subjects with regular blood sugar compared to subjects with prediabetes/diabetes mellitus type 2 regardless of age and gender. This means that with an increase in blood sugar levels, the degree of severity of osteoarthritis of the knee increases, since each subsequent Group has a higher average value of this indicator (p<0.05; CI 95%).
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Kijima, Hiroaki, Shin Yamada, Koji Nozaka, Hidetomo Saito, and Yoichi Shimada. "Relationship between Pain and Medial Meniscal Extrusion in Knee Osteoarthritis." Advances in Orthopedics 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/210972.
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Purpose. In knee osteoarthritis, the degree of pain varies despite similar imaging findings. If there were quantitative findings related to the pain of knee osteoarthritis, it could be used for diagnosis or screening. The medial meniscal extrusion was investigated as a candidate quantitative finding related to the pain of knee osteoarthritis.Methods. Seventy-six knees of 38 patients (mean age, 73 years) who received intra-articular injections of hyaluronic acid into unilateral knees at the time of diagnosis of knee arthritis were investigated. Cartilage thickness of the femoral medial condyle and medial meniscal extrusion of bilateral knees were measured by ultrasonography. Thirty-eight knees that had hyaluronic acid injections were compared with 38 other side knees from the same patients as the control group.Results. The average cartilage thicknesses of the knees with pain that received intra-articular injections and the knees without pain that received no injections were 1.02 and 1.05 mm, respectively (P=0.6394). On the other hand, the average medial meniscal extrusions of the knees with and without pain were 7.58 and 5.88 mm, respectively (P=0.0005); pain was associated with greater medial meniscal extrusions.Conclusion. Medial meniscal extrusion is a quantitative finding related to the pain of knee osteoarthritis.
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Jos, Sujit, Rajeev Anand, Nawfal Nazar, and Renju Jose. "A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population." International Journal of Research in Medical Sciences 6, no. 9 (2018): 3076. http://dx.doi.org/10.18203/2320-6012.ijrms20183647.
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Background: Hyperuricemia and knee osteoarthritis are common problems that affect the aging population and they have an increasing prevalence with obesity and hypertension. Epidemiologic and immunological studies have shown a possible relation between the two conditions. Uric acid is a common factor found in association with the evaluation and treatment of osteoarthritis. There are serious therapeutic implications, particularly in using traditional gout medications, for use in osteoarthritis treatment is to be explored in detail. Our diet contains a good amount of purine containing food stuffs. The common items which increase our uric acid levels are red meat, all alcoholic beverages, seafood and shellfish. Previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on the evidence of association between serum uric acid and knee joint osteoarthritis. This study aims to know the association between serum uric acid levels and osteoarthritis of knee joint.Methods: This is a Cross-sectional analytical study including eight hundred and thirty patients (461 males, 369 females) in a population screening during a patient education program on joint pains. Their serum uric acid level, total count, differential count, erythrocyte sedimentation rate (ESR), height, weight, blood pressure, BMI and standing radiographs of affected knees were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Kellgren-Lawrence system. The patients were divided into cohorts with hyperuricemia and osteoarthritis and compared with the subjects without either of the problems.Results: Isolated knee joint osteoarthritis is present in 183 subjects (22%), hyperuricemia was present in 154 subjects (18.55%). There is a significant positive association present between isolated knee joint osteoarthritis and the highest level of serum uric acid (adjusted odd’s ratio-2.24, 95% confidence interval-1.57-2.94). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest level versus lowest level of serum uric acid odd’s ratio-1.38, 95% confidence interval-0.96-2.74).Conclusions: It is concluded that knee joint osteoarthritis and its progression are associated with hyperuricemia.
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Linda Pertiwi, Ni Made, and Ni Luh Jaya Kirana. "Conventional Radiography of Grade III Knee Osteoarthritis: A Case Report." International Journal of Research and Review 10, no. 10 (2023): 536–40. http://dx.doi.org/10.52403/ijrr.20231068.
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Introduction: Osteoarthritis (OA) is the most common form of inflammatory joint disease. It occurs most frequently in the knees, hips, the spine (vertebrae), and ankles. Radiological prevalence of knee OA in Indonesia reaches 15.5% in men and 12.7% in women aged between 40-60 years. X-ray imaging is routinely used in clinical practice to confirm knee OA diagnosis and in clinical research to monitor the progression of knee OA. Case report: A 62-year-old female patient presented with knee pain in both knees that had been ongoing for the past 6 months. The pain was described as throbbing and stabbing, the right knee worse affected than the left. Palpation elicited tenderness, crepitus in both joints and did not reveal any deformities. Radiological AP/Lateral X-ray of the right knee revealed evidence of osteophytes, sclerosis and narrowing joint space, leading to the impression of Grade III osteoarthritis in the right knee. Discussion: Joint pain is the chief complaint that leads patients with knee osteoarthritis to seek medical attention. Pain typically worsens with movement and decreases with rest. In diagnosing OA, an AP/Lateral radiographic examination of the right knee is conducted, revealing the presence of osteophytes, subchondral bone sclerosis and accompanied by slight joint narrowing. This impression aligns with the Grade III OA criteria according to the Kellgren-Lawrence grading system. Conclusion: Diagnosis of osteoarthritis involves a comprehensive approach combining medical history, physical examination, and diagnostic tests. Radiographic examinations including conventional radiography play a significant role in diagnosing OA. In the early stages of the disease, joint radiographs may still appear normal. The severity of knee OA can be evaluated using the Kellgren-Lawrence (KL) grading scheme which ranges from grade 0 to grade 4. Keywords: Knee Osteoarthritis, Conventional Radiography, The Kellgren-Lawrence Grading
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Kivitz, Alan, Louis Kwong, Tammi Shlotzhauer, Joelle Lufkin, Amy Cinar, and Scott Kelley. "A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis." Therapeutic Advances in Musculoskeletal Disease 11 (January 2019): 1759720X1988130. http://dx.doi.org/10.1177/1759720x19881309.
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Background: Intra-articular corticosteroids are commonly used for pain relief in patients with knee osteoarthritis. Simultaneous intra-articular corticosteroid (CS) knee injections may be beneficial for the ~80–90% of patients who present with, or develop, bilateral knee osteoarthritis, but concurrent injections may increase systemic CS exposure and data on safety/tolerability are lacking. Triamcinolone acetonide extended release (TA-ER) has shown decreased systemic triamcinolone acetonide exposure compared with traditional triamcinolone acetonide crystalline suspension (TAcs) after a single knee injection in patients with knee osteoarthritis. This phase IIa study was designed to assess the safety and systemic triamcinolone acetonide exposure following injections of TA-ER or TAcs into each knee of patients with bilateral knee osteoarthritis. Methods: Patients (⩾40 years) meeting American College of Rheumatology criteria for knee osteoarthritis in both knees received concurrent single intra-articular injections of TA-ER 32 mg or TAcs 40 mg into each knee (total: 64 mg and 80 mg, respectively) and were followed for 6 weeks. Safety was evaluated based on treatment-emergent adverse events (TEAEs). Blood samples for pharmacokinetic analysis were collected pre-injection, and at the following postinjection time points: 1, 2, 3, 4, 5, 6, 8, 10, 12, and 24 h, and days 8, 15, 29, and 43. Results: Baseline characteristics were balanced between patients randomly assigned to TA-ER ( n = 12) or TAcs ( n = 12). Both treatments were well tolerated with comparable TEAE profiles. Peak plasma triamcinolone acetonide concentrations (Cmax) were lower following bilateral TA-ER injections [geometric mean, 2277.7 pg/ml (95% CI, 1602.13–3238.04)] compared with bilateral TAcs injections [7394.7 pg/ml (2201.06–24,843.43)], with median times to Cmax (Tmax) of 4.5 and 6.5 h, respectively. Conclusions: In patients with bilateral knee osteoarthritis, intra-articular injection of TA-ER into both knees was well tolerated. Consistent with pharmacokinetic profiles observed after a single knee injection, plasma triamcinolone acetonide concentrations were lower after bilateral TA-ER injections compared with the higher and more variable concentrations observed after bilateral TAcs injections. ClinicalTrials.gov identifier: NCT03378076
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Dung, Tran Trung. "Arthroscopic treatment for Intraarticular knee infection in Hanoi Medical University Hospital." Global Journal of Infectious Diseases and Clinical Research 3, no. 1 (2017): 025–27. https://doi.org/10.17352/2455-5363.000015.
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<strong>Objectives: </strong>1) Describe the arthroscopic image of infected osteoarthritis of knee; 2) Evaluate the result of arthroscopic treatment for infected osteoarthritis of knee <strong>Patients and method: </strong>Retrospective study 33 patients underwent arthroscopic treatment for infected osteoarthritis of knee in Hanoi Medical University Hospital from 2009 to 2013
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Gosikonda, Venu, Vamshidhar Reddy, and Ramu Chokkarapu. "Role of viscosupplementation in the management of primary osteoarthritis knee." International Journal of Research in Orthopaedics 3, no. 4 (2017): 841. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20172884.
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<p class="abstract"><strong>Background: </strong>Viscosupplementation is frequently used as a therapeutic strategy to manage patients with early osteo-arthritis of knees. A case series was followed up for a period of one year to study the clinical efficacy of intra-articular hyaluronic acid injections in different Kellegren Lawrence grades of osteoarthritis knee.</p><p class="abstract"><strong>Methods:</strong> 76 patients with primary osteoarthritis of knee not responding to analgesics, Quadriceps strengthening exercises, superficial and deep heat modalities were recruited after meeting inclusion criteria. They were followed up till the end of one year at an interval of every four months. Seventy patients completed the study and were analyzed for pain, stiffness and physical function using WOMAC osteoarthritis index. WOMAC scores were documented at initial consultation and follow up visits at the end of fourth, eighth and twelfth month.<strong></strong></p><p class="abstract"><strong>Results:</strong> Patients with Grade 1 and 2 osteoarthritis knee showed improvement in pain, stiffness and physical function following viscosupplementation lasting for one year. Those with Grade 3 osteoarthritis knee initially revealed good pain relief, enhanced function clinically till the second follow up. After that majority of the patients with Grade 3 osteoarthritis demanded for another session of viscosupplementation and expressed worsening of their knee symptoms. In Grade 4 osteoarthritis knee viscosupplementation found to be clinically and statistically ineffective. Adverse reactions following intra-articular hyaluronic acid injections included pain in five patients, pain and swelling in three patients, and injection site erythema in one patient.</p><p class="abstract"><strong>Conclusions:</strong> Viscosupplementation is a good therapeutic strategy in management of Grade 1-2 osteoarthritis knee. Intra-articular hyaluronic acid injections in Grade 3 osteoarthritis knee helps in delaying surgical intervention. It is in effective in Grade 4 osteoarthritis knee.</p>
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Reichenbach, S., M. Yang, F. Eckstein, et al. "Does cartilage volume or thickness distinguish knees with and without mild radiographic osteoarthritis? The Framingham Study." Annals of the Rheumatic Diseases 69, no. 01 (2009): 143–49. http://dx.doi.org/10.1136/ard.2008.099200.
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Objectives:To examine whether the quantity of cartilage or semiquantitative scores actually differ in knees with mild radiographic osteoarthritis compared with knees without osteoarthritis.Methods:Framingham Osteoarthritis Study participants had knee tibiofemoral magnetic resonance imaging-based measurements of cartilage. Using three-dimensional FLASH-water excitation sequences, cartilage volume, thickness and subregional cartilage thickness were measured and cartilage scored semiquantitatively (using the whole-organ magnetic resonance imaging score; WORMS). Using weight-bearing radiographs, mild osteoarthritis was defined as Kellgren/Lawrence (K/L) grade 2 and non-osteoarthritis as K/L grade 0. Differences between osteoarthritis and non-osteoarthritis knees in median cartilage measurements were tested using the Wilcoxon rank sum test.Results:Among 948 participants (one knee each), neither cartilage volume nor regional thickness were different in mild versus non-osteoarthritis knees. In mild osteoarthritis, cartilage erosions in focal areas were missed when cartilage was quantified over large regions such as the medial tibia. For some but not all subregions of cartilage, especially among men, cartilage thickness was lower (p<0.05) in mild osteoarthritis than non-osteoarthritis knees. Because semiquantitative scores captured focal erosions, median WORMS scores were higher in mild osteoarthritis than non-osteoarthritis (all p<0.05). In moderate/severe osteoarthritis (K/L grades 3 or 4), osteoarthritis knees had much lower cartilage thickness and higher WORMS scores than knees without osteoarthritis.Conclusions:In mild osteoarthritis, the focal loss of cartilage is missed by quantitative measures of cartilage volume or thickness over broad areas. Regional cartilage volume and thickness (eg, medial tibia) are not different in mild osteoarthritis versus non-osteoarthritis. Subregional thickness may be decreased in mild osteoarthritis. Semiquantitative scoring that assesses focal cartilage damage differentiates mild osteoarthritis from non-osteoarthritis.
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Omori, Go. "Abnormal Kinematics in Medial Knee Osteoarthritis." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015.27 (2015): 1. http://dx.doi.org/10.1299/jsmebio.2015.27.1_1.
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WISE, BARTON L., DAVID T. FELSON, MARGARET CLANCY, et al. "Consistency of Knee Pain and Risk of Knee Replacement: The Multicenter Osteoarthritis Study." Journal of Rheumatology 38, no. 7 (2011): 1390–95. http://dx.doi.org/10.3899/jrheum.100743.
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Objective.To examine whether the consistency or persistence of knee pain, in addition to its severity, predicts incident total knee replacement (TKR).Methods.The Multicenter Osteoarthritis Study (MOST) is a longitudinal study of persons aged 50 to 79 years with symptomatic knee osteoarthritis or at high risk of disease. Subjects were queried about the presence of knee pain on most days of the previous 30 days (i.e., frequent knee pain; FKP) at 2 timepoints: a telephone screen followed by a clinic visit (median separation 4 weeks). We defined a knee as having “consistent pain” if the subject answered positively to the FKP question at both timepoints, “inconsistent pain” if FKP was positive at only one timepoint, or as “no FKP” if negative at both. We examined the association between consistent FKP and risk of TKR using multiple binomial regression with generalized estimating equations.Results.In 3026 persons (mean age 63 yrs, mean body mass index 30.4), 2979 knees (50%) had no FKP at baseline, 1279 knees (21.5%) had inconsistent FKP, and 1696 knees (28.5%) had consistent FKP. Risk of TKR over 30 months was 0.8%, 2.6%, and 8.8% for knees with no, inconsistent, and consistent FKP, respectively. Relative risks of TKR over 30 months were 1.2 (95% CI 0.6–2.3) and 2.3 (95% CI 1.2–4.4) for knees with inconsistent and consistent FKP, compared with those without FKP. This association was consistent across each level of pain severity on the Western Ontario and McMaster Universities Osteoarthritis Index.Conclusion.Consistency of frequent knee pain is associated with an increased risk of TKR independently of knee pain severity.
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Olmos Calvo, Isabel, Eszter Fodor, Dorottya Kardos, et al. "A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects." Current Issues in Molecular Biology 43, no. 2 (2021): 637–49. http://dx.doi.org/10.3390/cimb43020046.
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The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Patients with knee osteoarthritis received three injections of autologous hyperacute serum; synovial fluid was harvested before each injection and clinical monitoring was followed-up for 6 months. Forty osteoarthritic-related cytokines, growth factors and structural proteins from synovial fluid were quantified and analysed by Multivariate Factor Analysis. Hyperacute serum provided symptomatic relief regarding pain and joint stability for OA patients. Both patients “with” and “without effusion knees” had improved VAS, KOOS and Lysholm-Tegner scores 6 months after of hyperacute serum treatment. Synovial fluid analysis revealed two main clusters of proteins reacting together as a group, showing strong and significant correlations with their fluctuation patterns after hyperacute serum treatment. In conclusion, hyperacute serum has a positive effect in alleviating symptoms of osteoarthritic knees. Moreover, identified protein clusters may allow the prediction of protein expression, reducing the number of investigated proteins in future studies.
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Knezevic, Aleksandar, Larisa Vojnovic, Dunja Popovic, Tijana Spasojevic, and Enis Garipi. "Knee osteoarthritis treatment." Medical review 75, Suppl. 2 (2022): 57–61. http://dx.doi.org/10.2298/mpns22s2057k.
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Introduction. Osteoarthritis is the most common form of arthritis which affects millions of people worldwide and represents the leading cause of disability among the elderly. There is a substantial number of guidelines available for the treatment of knee osteoarthritis. The primary aim of this paper is to explore the distinctions and similarities between knee osteoarthritis treatment guidelines. The treatment is divided into core treatment and additional steps. Core treatment of knee osteoarthritis involves education of the patient, weight loss in the case of overweight patients and establishing an exercise program. First step of additional treatment of knee osteoarthritis consists of non-pharmacological (application of orthoses, lateral wedge insoles, assistive walking devices, therapeutic modalities, manual therapy, aquatic exercise, Tai chi) and pharmacological therapy (topical nonsteroidal anti-inflammatory drugs, topical capsaicin, paracetamol). Second step of additional treatment of knee osteoarthritis - pharmacological therapy should be considered if the first step didn?t show any significant results. It involves the use of oral nonsteroidal antiinflammatory drugs, intra-articular corticosteroid injections and viscosupplementation. Third step of additional treatment of knee osteoarthritis - last resort pharmacological therapy Pain occurring in knee osteoarthritis. can be partially caused by central sensitization. Because of that, use of duloxetine and tramadol may be considered. Fourth step of additional treatment of knee osteoarthritis-end stage treatment of knee osteoarthritis is reserved for the most severe patients. It includes total knee replacement surgery, and if it is not possible, treatment with strong opioids could be considered. Conclusion There are many possibilities in treatment of knee osteoarthritis. Unfortunately, there is often a lack of concordance between different guidelines. In these circumstances, treatment plans should be personalized, while comprehending potential risks and benefits.
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Barrios, Joaquin A., and Danielle E. Strotman. "A Sex Comparison of Ambulatory Mechanics Relevant to Osteoarthritis in Individuals With and Without Asymptomatic Varus Knee Alignment." Journal of Applied Biomechanics 30, no. 5 (2014): 632–36. http://dx.doi.org/10.1123/jab.2014-0039.
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The prevalence of medial knee osteoarthritis is greater in females and is associated with varus knee alignment. During gait, medial knee osteoarthritis has been linked to numerous alterations. Interestingly, there has been no research exploring sex differences during walking in healthy individuals with and without varus alignment. Therefore, the gait mechanics of 30 asymptomatic individuals with varus knees (15 females) and 30 normally-aligned controls (15 females) were recorded. Gait parameters associated with medial knee osteoarthritis were analyzed with two-factor analyses of variance. In result, varus males exhibited the greatest peak knee adduction moments, while normal females showed the greatest peak hip adduction angles and pelvic drop excursions. By sex, females exhibited greater peak hip adduction angles and moments and greater pelvic drop excursion, but lesser peak knee adduction angles. By alignment type, varus subjects exhibited greater peak knee adduction angles and moments, midstance knee flexion angles and excursion, and eversion angles and lateral ground reaction forces, but lesser peak hip adduction angles. In conclusion, females generally presented with proximal mechanics related to greater hip adduction, whereas males presented with more knee adduction. Varus subjects demonstrated a number of alterations associated with medial knee osteoarthritis. The differential sex effects were far less conclusive.
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Hartana, Pande Made Yosira, Ni Luh Putu Gita Karunia Saraswati, Anak Agung Gede Eka Septian Utama, and I. Dewa Gede Alit Kamayoga. "Validation of the Indonesian version of Western Ontario and McMaster Universities osteoarthritis index in pre-elderly and elderly with osteoarthritis." Physical Therapy Journal of Indonesia 5, no. 2 (2024): 164–70. http://dx.doi.org/10.51559/ptji.v5i2.215.
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Background: This study aimed to examine the psychometric performance of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) version Indonesia used in pre-elderly and older adults in Indonesia with knee osteoarthritis and hip osteoarthritis. Methods: This study obtained samples from 124 pre-elderly and elderly individuals affected by knee and hip osteoarthritis in the Denpasar, Badung, and Gianyar areas to check the reliability and validity of the Indonesia WOMAC from Karsten et al. (2019). Knee and hip osteoarthritis were examined using the American College of Rheumatology (ACR) clinical criteria. Results: The Indonesian WOMAC was valid with a score of (0.809-0.964) for knee osteoarthritis, (0.870-0.982) for hip osteoarthritis, and (0.744-0.944) for knee osteoarthritis and hip osteoarthritis. It is reliable with Cronbach’s alpha score of (α = 0.992) for knee osteoarthritis, (α = 0.996) for hip osteoarthritis, and (α = 0.980) for knee osteoarthritis and hip osteoarthritis in pre-elderly and elderly patients. Conclusion: Based on the research results, the Indonesian WOMAC was valid and reliable for knee and hip osteoarthritis and is used in pre-elderly and elderly patients.
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Ghaznavi, Samina, Aneela Altaf Kidwai, Farhat Bashir, and Mahfooz Alam. "OSTEOARTHRITIS;." Professional Medical Journal 24, no. 10 (2017): 1579–83. http://dx.doi.org/10.29309/tpmj/2017.24.10.713.
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Objectives: To determine the pattern of symptomatic and radiographicosteoarthritis in the urban population of Karachi. Data Source: Outpatient clinics. Design ofStudy: Cross sectional observational. Setting: Liaquat National Hospital, Karachi. Period:August 2015 till July 2016. Materials and Methods: Symptomatic patients belonging to bothgenders, aged ≥ 30 years, having clinical and radiographic osteoarthritis involving knee, hip,spine, hand, foot and shoulder were included. Diagnosis of knee osteoarthritis was based onAmerican College of Rheumatology criteria, whereas the diagnosis of other joint areas wasbased on clinical and radiographic features. Patients were categorized as having monofocal ormultifocal osteoarthritis. The results were interpreted as frequencies and percentages. Results:Of the total 215 patients, 137 (63.7%) were females and 78 (36.27%) were males with meanage of 52.2 ± 9.3 years. Monofocal and multifocal osteoarthritis was found in 151 (70.23%) and64 (31.2%) patients respectively. Knee osteoarthritis (92.7%) was the most frequent monofocalpresentation. Of 64 patients with multifocal osteoarthritis, knee and hip joint were involved in28 (43.75%) and knee and hand osteoarthritis was found in 13 (20.3%) patients. Seven patients(10.9%) had osteoarthritis of three or more joints. Overall bilateral knee osteoarthritis wasfound in 158 (77.45%) patients. Conclusion: Bilateral symptomatic and radiographic kneeosteoarthritis was the most common presentation. Comparatively less proportion of patientshad osteoarthritis of three or more joints.
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Pelletier, Jean-Pierre, Patrice Paiement, Marc Dorais, Jean-Pierre Raynauld, and Johanne Martel-Pelletier. "Risk factors for the long-term incidence and progression of knee osteoarthritis in older adults: role of nonsurgical injury." Therapeutic Advances in Chronic Disease 14 (January 2023): 204062232311697. http://dx.doi.org/10.1177/20406223231169715.
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Background: For one of the most chronic medical conditions, osteoarthritis, uncertainties remain on the impact of injury chronology, the role of repeat injury on the incidence/progression of this disease and the need for knee arthroplasty. Objectives: To explore, in an older adult population, how nonsurgical knee injuries relate to osteoarthritis incidence/progression and the weight of independent risk factors for arthroplasty. Design: A cohort study design evaluates the long-term impact of injuries on knee osteoarthritis outcomes. Methods: Knees with no prior injury ( n = 6358) and with at least one injury ( n = 819) ⩽20 years before study inclusion were from the Osteoarthritis Initiative cohort. Sociodemographic, clinical and structural [X-ray, magnetic resonance imaging (MRI)] data at study inclusion and changes within 96 months were analysed. Statistics included a mixed model for repeated measurements, generalized estimating equations and multivariable Cox regression with covariates. Results: At inclusion, knees with prior injury demonstrated greater incidence and severity of osteoarthritis ( p ⩽ 0.001). At 96 months, there was a greater increase in symptoms [Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, p = 0.002], joint space width (JSW, p = 0.039) loss, medial cartilage volume loss (CVL, p ⩽ 0.001) and bone marrow lesion size (BML, p ⩽ 0.049). Knees with/without injury at inclusion but with new ones over time had a pronounced increase in symptoms (all WOMAC scores, p ⩽ 0.001), JSW loss, lateral (without) and medial CVL, lateral (without) and medial meniscal extrusion and medial BML (without; all p ⩽ 0.030). Levels of lateral and medial meniscal extrusion (without) and symptoms (with/without; all WOMAC scores, p ⩽ 0.001) were all accentuated with a repeated new injury. Risk factors associated with the highest knee arthroplasty occurrence are new meniscal extrusion and new injury ( p ⩽ 0.001). Conclusion: This study highlights the importance of nonsurgical knee injury in older adults as an independent risk factor for knee osteoarthritis and arthroplasty. These data will be beneficial in clinical practice as they will help identify individuals at greater risk of significant disease progression and worst disease outcomes for a customized therapeutic approach.
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Wu, Yahong, Cindy G. Boer, Amy Hofman, et al. "Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis." JAMA Network Open 7, no. 4 (2024): e248968. http://dx.doi.org/10.1001/jamanetworkopen.2024.8968.
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ImportanceIt has been demonstrated that total physical activity is not associated with risk of osteoarthritis. However, the association of different types of physical activity with incident knee osteoarthritis remains unclear.ObjectiveTo determine whether weight-bearing recreational physical activities are associated with increased risk of incident knee osteoarthritis.Design, Setting, and ParticipantsThis prospective cohort study used data from the Rotterdam Study (1996 to 2009), including participants with knee x-ray measurements at baseline and follow-up examinations. Participants with knee osteoarthritis at baseline were excluded. Residents aged 45 years and older of the Ommoord district in the city of Rotterdam in The Netherlands were invited to join the Rotterdam Study (78% response rate). Analysis was conducted in June 2023.ExposureTotal, weight-bearing, and non–weight-bearing recreational physical activities collected by questionnaires at baseline.Main Outcomes and MeasuresIncident radiographic knee osteoarthritis measured by knee x-ray was the primary outcome, and incident symptomatic knee osteoarthritis defined by x-ray and knee pain questionnaire was the secondary outcome. The association of different types of recreational physical activity with radiographic knee osteoarthritis was examined using logistic regression within generalized estimating equation framework after adjusting for potential confounders. A prespecified stratification analysis was planned on the basis of lower-limb muscle mass index (LMI) tertiles, measured by dual-energy x-ray absorptiometry.ResultsA total of 5003 individuals (2804 women [56.0%]; mean [SD] age, 64.5 [7.9] years) were included. The knee osteoarthritis incident rate was 8.4% (793 of 9483 knees) for a mean (SD) follow-up time of 6.33 (2.46) years. Higher weight-bearing activity was associated with increased odds of incident knee osteoarthritis (odds ratio [OR], 1.22; 95% CI, 1.10-1.35; P &amp;lt; .001), but non–weight-bearing activity was not (OR, 1.04; 95% CI, 0.95-1.15; P = .37). In the analysis stratified by LMI tertiles, the association of weight-bearing activity with incident osteoarthritis was found only among 431 patients in the lowest LMI tertile (OR, 1.53; 95% CI, 1.15-2.04; P = .003), but not among patients in the middle or high LMI tertile.Conclusions and RelevanceThe findings of this study suggest that weight-bearing activity is associated with incident knee osteoarthritis in people with low levels of lower-limb muscle mass, which might be a promising avenue for tailored advice for physical activity.
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Myszka, Anna, Janusz Piontek, Jacek Tomczyk, and Marta Zalewska. "Osteoarthritis – a problematic skeletal trait in past human populations. Osteoarthritic changes vs. entheseal changes in the late medieval and early modern population form Łekno." Anthropological Review 83, no. 2 (2020): 143–61. http://dx.doi.org/10.2478/anre-2020-0011.
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AbstractAccording to medical knowledge, physical activity plays a role in osteoarthritic changes formation. The impact of occupation on osteoarthritic changes development in past human populations is not clear enough, causing problems with interpretation. The aim of the current study is to examine the relationship between osteoarthritis and entheseal changes. Skeletal material comes from the late medieval, early modern population from Łekno (Poland). The sample consists of 110 males and 56 females (adults only). Osteophytes, porosity and eburnation were analyzed in the shoulder, elbow, wrist, hip, knee, and ankle. Entheses on the humerus, radius, femur, and tibia were examined. Standard ranked categorical scoring systems were used for the osteoarthritic and entheseal changes examination.Males with more developed osteophytes in the shoulder have more “muscular” upper limbs (higher values of muscle markers). Males with more developed osteophytes in the hip and knee are predicted to have more “muscular” lower limbs. Males with more developed osteoarthritis in the shoulder, wrist, hip, and knee exhibit more developed entheseal changes. Males with more developed entheses tend to yield more developed osteophytes (all joints taken together) and general osteoarthritis (all changes and all joints taken together). Females with more developed entheses have more developed osteoarthritis in the elbow, wrist, and hip. Individuals with more developed entheses have much more developed osteophytes. When all the three types of changes are taken together, more “muscular” females exhibit more developed osteoarthritis. The lack of uniformity of the results, wild discussions on the usage of entheses in activity patterns reconstruction and other limitations do not allow to draw unambiguous conclusions about the impact of physical activity on the osteoarthritis in past populations and further studies are needed.
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Ahsaniyah, Andi Besse, Nahdiah Purnamasari, Nurhikmawaty Hasbiah, and Nur Anugrawati Irwan. "Efektivitas Stability Ball Exercise Dalam Menurunkan Intensitas Nyeri Pinggang Selama Kehamilan." Jurnal Fisioterapi dan Rehabilitasi 6, no. 2 (2022): 67–73. http://dx.doi.org/10.33660/jfrwhs.v6i2.160.
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Latar Belakang : Osteoarthritis (OA ) adalah salah satu penyakit degenerative yang ditandai dengan hilangnya tulang rawan articular dan terjadi peradangan sinovial sehingga menyebabkan kekakuan sendi, nyeri dan hilangnya mobilitas. Tujuan : Untuk mengetahui efektifitas terapi dengan modalitas TENS dan latihan isometrik pada pasien knee osteoarthritsi. Hasil : Setelah dilakukan terapi sebanyak 5 kali didapatkan hasil pengurangan nyeri diam dari T0 -T5 : 0, nyeri tekan T0-T5 : 1, nyeri gerak T0-T5 : 5, MMT T0-T5 : 5, nilai LGS knee dextra aktif T0-T5 : S = 00 – 0 - 1250, knee dextra pasif T0-T5 S = 00 – 0 - 1300, knee sinistra aktif T0-T5 S = 00 – 0 - 1300, knee sinistra pasif T0-T5: S = 00 – 0 - 1300. Simpulan : Rehabilitasi dan latihan yang diberikan pada pasien knee osteoarthritis menggunakan modalitas TENS dan latihan isometric mendukung optimalisasi terkait kondisi fisik, pengurangan nyeri, peningkatan kekuatan otot dan aktifitas fungsional pasien.