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Relevant bibliographies by topics / Knock-out CB1R-/- mouse

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Journal articles

Academic literature on the topic 'Knock-out CB1R-/- mouse'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Knock-out CB1R-/- mouse"

1

Morozov, Yury M., Ken Mackie, and Pasko Rakic. "Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration." International Journal of Molecular Sciences 21, no. 22 (2020): 8657. http://dx.doi.org/10.3390/ijms21228657.

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Cannabinoid type 1 receptor (CB1R) is expressed and participates in several aspects of cerebral cortex embryonic development as demonstrated with whole-transcriptome mRNA sequencing and other contemporary methods. However, the cellular location of CB1R, which helps to specify molecular mechanisms, remains to be documented. Using three-dimensional (3D) electron microscopic reconstruction, we examined CB1R immunolabeling in proliferating neural stem cells (NSCs) and migrating neurons in the embryonic mouse (Mus musculus) and rhesus macaque (Macaca mulatta) cerebral cortex. We found that the mito

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2

Máthé, Domokos, Ildikó Horváth, Krisztián Szigeti, et al. "In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB(1) receptor antagonist radioligand [(125)I]SD7015 in CB(1) knock-out and wildtype mouse." Brain Res Bull. 91C (January 11, 2013): 46–51. https://doi.org/10.1016/j.brainresbull.2013.01.001.

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We aimed to evaluate the novel high-affinity and relatively lipophilic CB(1) receptor (CB(1)R) antagonist radioligand [(125)I]SD7015 for SPECT imaging of CB(1)Rs in vivo using the multiplexed multipinhole dedicated small animal SPECT/CT system, NanoSPECT/CT(PLUS) (Mediso, Budapest, Hungary), in knock-out CB(1) receptor knock-out (CB(1)R-/-) and wildtype mice. In order to exclude possible differences in cerebral blood flow between the two types of animals, HMPAO SPECT scans were performed, whereas in order to confirm the brain uptake differences of the radioligand between knock-out mice and wil

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3

Chioccarelli, Teresa, Francesco Manfrevola, Veronica Porreca, et al. "The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation." International Journal of Molecular Sciences 21, no. 9 (2020): 3117. http://dx.doi.org/10.3390/ijms21093117.

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The cannabinoid receptor CB1 regulates differentiation of spermatids. We recently characterized spermatozoa from caput epididymis of CB1-knock-out mice and identified a considerable number of sperm cells with chromatin abnormality such as elevated histone content and poorly condensed chromatin. In this paper, we extended our findings and studied the role of CB1 in the epididymal phase of chromatin condensation of spermatozoa by analysis of spermatozoa from caput and cauda epididymis of wild-type and CB1-knock-out mouse in both a homozygous or heterozygous condition. Furthermore, we studied the

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4

Máthé, Domokos, Ildikó Horváth, Krisztián Szigeti, et al. "In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse." Brain Research Bulletin 91 (February 2013): 46–51. http://dx.doi.org/10.1016/j.brainresbull.2013.01.001.

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5

Zaryouh, Hannah, Ines De Pauw, Hasan Baysal, et al. "Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity." Cancer Drug Resistance 6, no. 4 (2023): 709–28. http://dx.doi.org/10.20517/cdr.2023.62.

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Aim: Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma (HNSCC). To accurately study novel combination treatments, suitable preclinical mouse models for cetuximab resistance are key yet currently limited. This study aimed to optimize an acquired cetuximab-resistant mouse model, with preservation of the innate immunity, ensuring intact antibody-dependent cellular cytotoxicity (ADCC) functionality. Methods: Cetuximab-sensitive and acquired-resistant HNSCC cell lines, generated in

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6

Zawatsky, Charles N., Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, and Resat Cinar. "Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis." Frontiers in Endocrinology 12 (September 28, 2021). http://dx.doi.org/10.3389/fendo.2021.744857.

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Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible NO synthase (iNOS) promote tissue fibrosis including skin fibrosis, and joint targeting of these pathways may improve therapeutic efficacy. Recently, we showed that in mouse models of liver, lung and kidney fibrosis, treatment with a peripherally restricted hybrid CB1R/iNOS inhibitor (MRI-1867) yields greater anti-fibrotic efficacy than inhibi

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7

Chioccarelli, Teresa, Geppino Falco, Donato Cappetta, et al. "FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development." Cellular and Molecular Life Sciences 79, no. 1 (2021). http://dx.doi.org/10.1007/s00018-021-04054-8.

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AbstractCircular RNA (circRNA) biogenesis requires a backsplicing reaction, promoted by inverted repeats in cis-flanking sequences and trans factors, such as RNA-binding proteins (RBPs). Among these, FUS plays a key role. During spermatogenesis and sperm maturation along the epididymis such a molecular mechanism has been poorly explored. With this in mind, we chose circCNOT6L as a study case and wild-type (WT) as well as cannabinoid receptor type-1 knock-out (Cb1−/−) male mice as animal models to analyze backsplicing mechanisms. Our results suggest that spermatozoa (SPZ) have an endogenous ski

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8

Nagre, Nagaraja, Gregory Nicholson, Xiaofei Cong, et al. "Activation of cannabinoid-2 receptor protects against Pseudomonas aeruginosa induced acute lung injury and inflammation." Respiratory Research 23, no. 1 (2022). http://dx.doi.org/10.1186/s12931-022-02253-w.

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Abstract Background Bacterial pneumonia is a major risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Pseudomonas aeruginosa (PA), an opportunistic pathogen with an increasing resistance acquired against multiple drugs, is one of the main causative agents of ALI and ARDS in diverse clinical settings. Given the anti-inflammatory role of the cannabinoid-2 receptor (CB2R), the effect of CB2R activation in the regulation of PA-induced ALI and inflammation was tested in a mouse model as an alternative to conventional antibiotic therapy. Methods In order to activ

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