Academic literature on the topic 'Knoevenagel condensation reactions'

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Journal articles on the topic "Knoevenagel condensation reactions"

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Hu, Xiao Mei, Yang Zhao, Yun Fei Gao, Yi Bo Xiao, and Bi Xian Zhang. "Knoevenagel Reactions in Ionic Liquids." Advanced Materials Research 554-556 (July 2012): 557–61. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.557.

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Ionic liquids (ILs) as “green solvents” provided an effective and efficient procedure for Knoevenagel condensation reactions. It is applicable for a large range of aldehydes, ketones with active methylene compounds. ILs can significantly promote the reaction rates. High yields and selectivity of products have been observed. ILs can be recycled and reused. In this paper, the recent achievements of Knoevenagel condensation reactions promoted by ILs are reviewed.
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Badiger, Krishnappa B., and Kantharaju Kamanna. "Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst." Organic Communications 14, no. 1 (2021): 81–91. http://dx.doi.org/10.25135/acg.oc.99.21.01.1948.

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This paper present a novel Knoevenagel reaction protocol for the condensation of aromatic/heteroaromatic aldehydes with malononitrile to give α, β–unsaturated benzylidene derivatives. The main focus of this work is to reveal the usability of agro-waste extracts as a catalyst in the Knoevenagel condensation. The present protocol proceeds efficiently for various substituted aromatic and heterocyclic aldehydes in the Knoevenagel reactions. In addition, the present method describes direct isolation of the formed products without using organic solvent extraction gave good yields product.
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Jimenez, David Esteban Quintero, Lucas Lima Zanin, Luan Farinelli Diniz, Javier Ellena, and André Luiz Meleiro Porto. "Green Synthetic Methodology of (E)-2-cyano-3-aryl Selective Knoevenagel Adducts Under Microwave Irradiation." Current Microwave Chemistry 6, no. 1 (2019): 54–60. http://dx.doi.org/10.2174/2213335606666190906123431.

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Background: The Knoevenagel condensation is an important reaction in organic chemistry because of its capacity to form new C-C bonds and its products are mainly used in organic synthesis as intermediates, due to the large number of reactions they can undergo. Based on the importance of the Knoevenagel adducts, a sustainable synthetic methodology was developed employing microwave irradiation. Objective: Develop a synthetic methodology employing microwave irradiation and green solvents to obtain Knoevenagel adducts with high yields. Methods: Knoevenagel condensation reactions were evaluated with
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Fan, Xuesen, Xueyuan Hu, Xinying Zhang, and Jianji Wang. "Ionic Liquid Promoted Knoevenagel and Michael Reactions." Australian Journal of Chemistry 57, no. 11 (2004): 1067. http://dx.doi.org/10.1071/ch04060.

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The utilization of the ionic liquid [bmim][BF4] as both reaction medium and promoter for the Knoevenagel condensation and Michael addition reactions is described in this paper. Through these reactions, several useful electrophilic alkenes and chromene derivatives are obtained in high yields. The advantages of these two novel procedures include their environmentally benign nature, atom economy, simple operation process, and mild reaction conditions.
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Hayashi, Shun, Seiji Yamazoe, Kiichirou Koyasu, and Tatsuya Tsukuda. "Application of group V polyoxometalate as an efficient base catalyst: a case study of decaniobate clusters." RSC Advances 6, no. 20 (2016): 16239–42. http://dx.doi.org/10.1039/c6ra00338a.

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We demonstrated for the first time that [Nb<sub>10</sub>O<sub>28</sub>]<sup>6−</sup> exhibited base catalytic activity for aldol-type condensation reactions including Knoevenagel and Claisen–Schmidt condensation reactions.
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Gouda, Moustafa. "LiOH.H2O as a catalyst for Knoevenagel and Gewald reactions." Polish Journal of Chemical Technology 12, no. 4 (2010): 31–35. http://dx.doi.org/10.2478/v10026-010-0046-6.

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LiOH.H2O as a catalyst for Knoevenagel and Gewald reactions Commercial available lithium hydroxide monohydrate LiOH.H2O was found to be a novel ‘dual activation’ catalyst for tandem cross Knoevenagel condensation between malononitrile or ethylcyanoacetate and aromatic aldehydes leading to an efficient and easy synthesis of the corresponding arylidenes at room temperature in a short reaction time. In the case of salicyaldehyde the reaction lead to the formation of 3-substituted coumarins. The high efficacy, cheapness and easy availability of LiOH.H2O prompted us to investigate its validity as a
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Lv, Hongxiao, Liming Fan, Hongtai Chen, Xiutang Zhang, and Yanpeng Gao. "Nanochannel-based {BaZn}–organic framework for catalytic activity on the cycloaddition reaction of epoxides with CO2 and deacetalization-Knoevenagel condensation." Dalton Transactions 51, no. 9 (2022): 3546–56. http://dx.doi.org/10.1039/d1dt04231a.

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Nanochannel-based {[(CH3)2NH2]2[BaZn(TDP)(H2O)]×DMF×5H2O}n (NUC-51) is synthesized and displays a high catalytic activity on the cycloaddition reactions of epoxides with CO2 and the deacetalization-Knoevenagel condensation reaction.
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Nagaraju, Sakkani, Neeli Satyanarayana, Banoth Paplal, et al. "One-pot synthesis of functionalized isoxazole–thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions." RSC Advances 5, no. 114 (2015): 94474–78. http://dx.doi.org/10.1039/c5ra16721c.

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One-pot synthesis of isoxazole–thiolane hybrids are reported via the Knoevenagel condensation, domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions using piperidine (30 mol%) with &gt;95% yields in 2–2.5 h overall reaction time.
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Hinde, Christopher S., William R. Webb, Benny K. J. Chew, et al. "Utilisation of gold nanoparticles on amine-functionalised UiO-66 (NH2-UiO-66) nanocrystals for selective tandem catalytic reactions." Chemical Communications 52, no. 39 (2016): 6557–60. http://dx.doi.org/10.1039/c6cc02169g.

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Bahammou, Imane, Ayoub Esaady, Said Boukhris, et al. "Direct use of mineral fertilizers MAP, DAP, and TSP as heterogeneous catalysts in organic reactions." Mediterranean Journal of Chemistry 5, no. 6 (2016): 615–23. http://dx.doi.org/10.13171/mjc56/01607062219-souizi.

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In this paper, we reported the first use of phosphate fertilizers (MAP, DAP, and TSP) as heterogeneous catalysts for organic reactions. Their catalytic activities were investigated in the first time in Knoevenagel condensation of various aromatic aldehydes with malononitrile at room temperature. These minerals phosphate showed high catalytic activities and ability to be recovering and reusing without a significant loss in their catalytic activities. In order to reach the optimal reaction conditions for Knoevenagel condensation, we carried out a kinetic study of the effect of reaction time,
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Dissertations / Theses on the topic "Knoevenagel condensation reactions"

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MARTIN, BENOIT. "Reactions de condensation sans solvant sous irradiation micro-ondes : synthese de produits de knoevenagel et d'heterocycles azotes." Caen, 1996. http://www.theses.fr/1996CAEN2009.

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Une etude de la reaction de knoevenagel en milieu heterogene sans solvant et sous irradiation micro-ondes est presentee. Des composes d'interet synthetique et biologique potentiel sont syntheties grace au couplage de l'activation micro-ondes avec la catalyse supportee ou avec la catalyse par transfert de phase sans solvant: synthese de 5-nitrofurfurylidenes et de ferrocenylenones. Une methode generale de preparation des produits de knoevenagel a partir de composes heterocycliques a methylene acide a ete mise au point. Cette methode, utilisant le fluorure de potassium depose sur alumine comme b
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Vieira, Thiago Antonio. "Síntese de C-glicosídeos e derivados a partir de fontes renováveis." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/97/97136/tde-03122018-170834/.

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Os carboidratos são componentes essenciais de muitos produtos naturais de grande importância medicinal. As porções carboidrato podem aumentar a solubilidade em água de drogas, diminuir a toxicidade e/ou contribuir para a bioatividade dos produtos naturais. A síntese de C-glicosídeos, a partir de D-glicose, é de grande interesse porque estes são úteis como blocos de construção para a síntese de vários tipos de moléculas com grande potencial de utilização em princípios ativos para tratamento de câncer, diabetes, HIV, como antivirais, entre outros. Os C-glicosídeos são essencialmente inertes à de
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Ambeu, N'ta Christelle. "Synthèse d'analogues de la pentamidine porteurs de plateformes hétérocycliques (rhodanine, benzimidazole, pyrazole et imidazole) et leurs évaluations biologiques." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S137/document.

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Ce manuscrit de thèse concerne le développement d'une stratégie de synthèse multi-étapes de nouveaux composés comportant plusieurs plateformes hétérocycliques (rhodanine, benzimidazole, pyrazole et imidazole) à visée thérapeutique multiple contre la malaria, la leishmaniose, le cancer et les maladies neurodégénératives. Les pharmacomodulations de ces composés ont été élaborées sur la base du modèle de la pentamidine 35 comportant 2 motifs benzamidines (parties « Ouest » et « Est »). En effet, la substitution de sa partie « Ouest » par une plateforme rhodanine ou benzimidazole et de sa partie «
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Nguyen, Thi Thao. "Synthèse et étude de dérivés porteurs du motif 1,3-dithiole-2-ylidene actifs en optique non linéaire de deuxième et troisième ordre." Angers, 1996. http://www.theses.fr/1996ANGE0003.

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Ce travail porte sur la synthèse et l'étude de molécules potentiellement actives en optique non linéaire (ONL). Les chromophores pour l'ONL de 2ème ordre possèdent un groupement donneur d et un groupement accepteur a séparés par un espaceur conjugué e (d-e-a), d étant ici un groupement 1,3-dithiole-2-ylidene diversement substitué en position 4,5. Dans le but d'améliorer les performances non linéaires de ces molécules, on fait varier: i) le nombre de doubles liaisons conjuguées de l'espaceur e, ii) la nature de l'accepteur a (groupes carbonyle, carboxyalkyle, gem dicyano, p-nitrophenyle, 5-nitr
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Burgoyne, Andrew R. "Knoevenagel and Heck catalytic studies with Metal Organic Frameworks (MOFs)." Thesis, 2013. http://hdl.handle.net/10210/8545.

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Subudhi, Prabhat Kumar. "Synthesis, characterization and catalytic applications Of CeO2- MgO nanocomposite oxide for Knoevenagel Condensation reaction." Thesis, 2011. http://ethesis.nitrkl.ac.in/2119/1/Prabhat_M.Sc_thesis.pdf.

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A series of CeO2-MgO nanocomposite oxides were prepared by gel combustion method. The nanocomposite oxides were characterized by XRD, UV and SEM techniques. The presence of well dispersed ceria nanoparticles in MgO matrix was ascertained from the XRD and UV study. SEM study indicated the material to be porous and low density in nature. The CeO2-MgO composite oxide was used as an efficient heterogeneous catalyst for the Knoevenagel condensation of aromatic aldehydes and malononitrile.
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Book chapters on the topic "Knoevenagel condensation reactions"

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Li, Jie Jack. "Knoevenagel condensation." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_147.

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Li, Jie Jack. "Knoevenagel condensation." In Name Reactions. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_152.

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Li, Jie Jack. "Knoevenagel condensation." In Name Reactions. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_138.

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Li, Jie Jack. "Knoevenagel Condensation." In Name Reactions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50865-4_77.

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Ghosh, Mithun Kumar, and Tanmay Kumar Ghorai. "Advantages of Nanocatalysts on Knoevenagel Condensation." In Diverse Strategies for Catalytic Reactions. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815079036123020007.

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Nanocatalysts revolutionize organic chemistry for the conversion of various organic reactions to obtain a high yield, low hazard and stability. It plays an important role in the transformation of organic reactions due to its high surface area, small size, and low reaction time. Therefore, green methodology, both in the synthesis of nanocatalysts and organic transformation reactions, is an advanced technology, and findings promise results. Many scientists all over the world synthesised nanoparticles and used them as catalysts in Knoevenagel condensation. In this book chapter, we documented the
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Ebitani, K. "2.14 Other Condensation Reactions (Knoevenagel, Perkin, Darzens)." In Comprehensive Organic Synthesis II. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-08-097742-3.00215-9.

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"α-Substitution Reactions in Carboxylic Acids and Derivatives." In The Chemistry of Carbonyl Compounds and Derivatives. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781837670888-00381.

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The chemistry of carboxylic acid derivatives containing at least one hydrogen α to the carbonyl group is the focus of this chapter. The synthesis of β-ketoesters by the Claisen condensation illustrates the enolization and condensation processes guided by the pKa difference between the nucleophile and the product. The importance of malonic and acetoacetic esters for the preparation of carboxylic acids and derivatives (malonic ester synthesis) and ketones (acetoacetic ester synthesis) is presented. The biosynthetic relevance of the Claisen and Dieckmann condensations in the metabolism and the sy
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Khaligh, Nader G., Salam J. J. Titinchi, and Hanna S. Abbo. "Metal-free Knoevenagel Condensation and Other Condensation Reactions (Perkin, Darzens)." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-323-96025-0.00075-2.

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Das, Samarpita, Pulkit Asati, Harish K. Indurthi, Ashutosh Kumar Dash, and Deepak K. Sharma. "Recent Trends of Chromene Syntheses." In The Role of Chromenes in Drug Discovery and Development. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124330123010004.

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2H/4H-chromenes (2H/4H-Ch) structural scaffolds have been widely employed in the synthesis of many natural products and medicinal agents. 2H/4H-Ch have attracted considerable attention due to their various pharmacological activities, such as anticonvulsant, anticholinesterase, anticancer, anti-tuberculosis, antimicrobial, and inhibitory activity against monoamine oxidase (MAO), and anti-diabetic activities. In literature, the synthesis of 4H-chromenes was performed by one-pot Knoevenagel condensation of resorcinol, aryl aldehydes, and malononitrile in the presence of basic catalysts. Also, 2H-
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"Knoevenagel Condensation Reaction." In Laboratory Experiments Using Microwave Heating. CRC Press, 2013. http://dx.doi.org/10.1201/b14645-7.

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Conference papers on the topic "Knoevenagel condensation reactions"

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Wu, Yiting, Weitong Xiao, Jingyang Chen, and Weiling Luan. "BODIPY as a Photosensitizer for Photodynamic Therapy: Mechanisms, Functionalization, and Future Prospects." In 6th International Conference on Structural Health Monitoring and Integrity Management, 8 - 10 November 2024, Zhengzhou. NDT.net, 2025. https://doi.org/10.58286/30976.

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Photodynamic therapy (PDT) has the advantages of strong targeting, few side effects, and little damage to normal tissues, which is considered as a high-quality new non-invasive treatment for cancer treatment. Photosensitizer (PSs), molecular oxygen and light are the three main components of PDT. Boron-dipyrromethene (BODIPY) is a widely used organic fluorescent dye, and its core structure is composed of a central boron atom (B) and two pyrrole rings connected by a methylene bridge. The eight active sites on the parent nucleus allow for a variety of functionalization modifications: positions 2,
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Cai, X. W., X. Zhang, H. H. Yan, and Y. Y. Zhao. "The progress of the functionalized ionic liquids in the application of Knoevenagel condensation reaction." In The 2015 International Conference on Sustainable Development (ICSD2015). WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814749916_0118.

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