Relevant bibliographies by topics / Korsmeyer-Peppas model

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  2. Dissertations / Theses
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Academic literature on the topic 'Korsmeyer-Peppas model'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 June 2025

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Journal articles on the topic "Korsmeyer-Peppas model"

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Lisik, Anna, and Witold Musiał. "Conductomeric Evaluation of the Release Kinetics of Active Substances from Pharmaceutical Preparations Containing Iron Ions." Materials 12, no. 5 (2019): 730. http://dx.doi.org/10.3390/ma12050730.

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The aim of this study was to verify the effect of the formulation on the release kinetics of active substances from preparations containing iron ions using in-line conductivity measurements. A simple, fast method was developed and may be applied for detailed evaluation of some kinetics factors obtained from the release data. Four different equations were used: zero-order equation, first-order equation, models: Korsmeyer–Peppas and Hixson–Crowell. Values of the determined half-time release for zero and first-order kinetic models ranged from 11.56 to 89.97 min. In the case of analysis according
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Craciun, Anda Mihaela, Georgiana Serban, Iulia Crumpei, Maricel Agop, and Gabriela Cioca. "Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels." Materiale Plastice 55, no. 4 (2018): 590–94. http://dx.doi.org/10.37358/mp.18.4.5080.

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We build a theoretical model based on a generalization of harmonic applications of Misner-type. It results a sine-Gordon type fractal differential equation whose elliptical solutions can describe, through a convenient choice of fractal dynamic constants, various modes of drug release. Thus, the entire class of empirical models (Higuchi, Korsmeyer-Peppas, Peppas-Sahlin) describing the drug release processes can be dispensed with.
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Danarto, YC, Anggita Nugrahey, and Sela Murni Noviani. "Kinetika Slow Release Pupuk Urea Berlapis Chitosan Termodifikasi." Equilibrium Journal of Chemical Engineering 1, no. 2 (2017): 45. http://dx.doi.org/10.20961/equilibrium.v1i2.40422.

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<p>During this time, the use of urea is not efficient, because about 40-70% of nitrogen in the fertilizer is not absorbed by plants. In order to increase the effectivity of nitrogen release in urea fertilizer, it needs to be coated with modified chitosan as slow releasing agent to form a hydrogel material by forming a cross linking with glutaraldehyde cross-linker.The aims of this research is to study the mechanism and the appropriate kinetic model of nitrogen release in slow releasing fertilizer of modified chitosan. This research was conducted by analyzing the ability of bio-hydrogel b
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Hernawan, Hernawan, Septi Nurhayati, Khoirun Nisa, A. W. Indrianingsih, Cici Darsih, and Muhammad Kismurtono. "FORMULATION AND IN VITRO STUDY OF PROPRANOLOL HYDROCHLORIDE CONTROLLED RELEASE FROM CARBOXYMETHYL CHITOSAN-BASED MATRIX TABLETS." Indonesian Journal of Chemistry 13, no. 3 (2013): 242–47. http://dx.doi.org/10.22146/ijc.21283.

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Formulation and in vitro study of propranolol hydrochloride controlled release from carboxymethyl chitosan-based matrix tablets have been conducted. Formulations with various concentrations of carboxymethyl chitosan 2% (F1), 4% (F2), 6% (F3) were done by wet granulation method. Compatibility test was conducted by XRD and FTIR spectroscopy to determine interaction between propranolol hydrochloride and polymer excipients. Dissolution profiles was obtained through in vitro tests release using simulated gastric fluid (without enzymes, pH 1.2) for the first 2 h and followed by simulated intestinal
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Widyastuti, Lina, and Akhmad Kharis Nugroho. "Profil Pelepasan Andrografolid Granul Kombinasi Ekstrak Terpurifikasi Herba Pegagan (Centeella Asiatica) Dan Sambiloto (Andrographis Paniculata)." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 3, no. 2 (2018): 58. http://dx.doi.org/10.20473/jfiki.v3i22016.58-61.

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Pendahuluan: Andrografolid merupakan senyawa yang sukar larut dalam air, penentuan jumlah dan profil pelepasan andrografolid dari bentuk sediaan perlu dilakukan. Tujuan: Penelitian ini dilakukan untuk menentukan jumlah dan profil andrografolid yang dilepaskan dari formula granul kombinasi ekstrak terpurifikasi herba pegagan dan herba sambiloto. Hal tersebut untuk memastikan eksipien tidak mengikat zat aktif. Metode: Uji pelepasan dilakukan dengan melakukan uji disolusi menggunakan media dapar asetat pH 4,5. Hasil disolusi granul kombinasi ekstrak terpurifikasi herba pegagan dan herba sambiloto
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Setyawan, Eka Indra, Abdul Rohman, Erna Prawita Setyowati, and Akhmad Kharis Nugroho. "The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch." Pharmacia 68, no. 1 (2021): 275–82. http://dx.doi.org/10.3897/pharmacia.68.e61734.

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Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The correlation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higu
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7

Jayanudin, Jayanudin, R. Rochmadi, Meri Yulvianti, Ahmad Imanudin, and Tri Rina Sari. "Kinetika Release Mikrokapsul Oleoresin Jahe Merah." REAKTOR 16, no. 3 (2017): 128. http://dx.doi.org/10.14710/reaktor.16.3.128--140.

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Abstract RELEASE KINETICS OF RED GINGER OLEORESIN MICROCAPSULES. Red ginger oleoresin microcapsule is used to protect the active component of medicine against the negative effect of the environment, thus the microcapsule can be applied in the pharmaceutical industries. Kinetic release is used to determine the rate of red ginger oleoresin microcapsule release in human body system. The models used for this purpose are zero order, first order, Higuchi, and Korsmeyer-Peppas. These models were completed by using graphical method to get the determination coefficient (R2). The aims of this research a
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8

Ruan, Xiangchun, Xiuge Gao, Ying Gao, et al. "Preparation and in vitro release kinetics of ivermectin sustained-release bolus optimized by response surface methodology." PeerJ 6 (July 31, 2018): e5418. http://dx.doi.org/10.7717/peerj.5418.

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Sustained-release formulations of ivermectin (IVM) are useful for controlling parasitic diseases in animals. In this work, an IVM bolus made from microcrystalline cellulose (MCC), starch and low-substituted hydroxypropyl cellulose (LS-HPC) was optimized by response surface methodology. The bolus was dissolved in a cup containing 900 mL of dissolution medium at 39.5 °C, under with stirring at 100 rpm. A quadratic model was formulated using analysis of variance according to the dissolution time. The optimized formulation of the bolus contained 8% MCC, 0.5% starch, and 0.25% LS-HPC. The length, w
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Baihaqi, Ahmad Ichsan, Dyah Utami Cahyaning Rahayu, and E. Budianto. "Effect of Drug Loading Method on Drug Dissolution Mechanism of Amoxicillin Trihydrate Encapsulated in Chitosan-Poly(N-Vinylpyrrolidone) Full-IPN Hydrogel as a Floating Drug Delivery System Matrix." Materials Science Forum 964 (July 2019): 251–56. http://dx.doi.org/10.4028/www.scientific.net/msf.964.251.

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Amoxicillin trihydrate suits to be encapsulated into a modified matrix to increase its bioavailability. In this study, the effect of drug loading methods on drug dissolution mechanism from chitosan-poly(N-vinylpyrrolidone) hydrogel with CaCO3 as the effervescent agent has been studied. It was found that the encapsulation efficiency of in situ and post loading methods were 93% and 75%, respectively. The dissolution values were 94% and 98%, respectively for in situ and post loading. The dissolution test data was incorporated into zero-order, first-order, Higuchi and Korsmeyer-Peppas models to ev
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10

Patel, S. S., M. R. Patel, and M. J. Patel. "Formulation and Evaluation of Microsponge Based Nicorandil Sustained Released Tablet." Journal of Scientific Research 9, no. 3 (2017): 285–96. http://dx.doi.org/10.3329/jsr.v9i3.31193.

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The aim of the present work was to develop once-daily sustained release microsponges formulations of Nicorandil, a potent potassium channel opener used in cardiovascular diseases and it has low oral bioavailability (70%) and half-life 1 h. So, it is good candidate for sustained release formulations based on microsponge technology. The microsponges were prepared by using quasi-emulsion solvent diffusion method. Scanning Electron Microscopy (SEM) revealed that the microsponges of nicorandil with Eudragit - RSPO and HPMC K100M were smooth, porous, glossy and discrete spherical. The actual drug co
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Dissertations / Theses on the topic "Korsmeyer-Peppas model"

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Oborná, Jana. "Řízené uvolňování léčiv z biodegradabilních hydrogelů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-385283.

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This dissertation is focused on the controlled release of drugs from a biodegradable amphiphilic hydrogel based on hydrophobic poly(lactic acid), poly(glycolic acid) and hydrophilic poly(ethylene glycol) (PLGA-PEG-PLGA, ABA) and its modification with itaconic anhydride (ITA). The resulting ,-itaconyl(PLGA-PEG-PLGA) copolymer is referred to as ITA/PLGA-PEG-PLGA/ITA or ITA/ABA/ITA. Itaconic acid provides reactive double bonds and a functional carboxyl group at the ends of the PLGA-PEG-PLGA copolymer chain, thereby rendering the modified ITA/ABA/ITA copolymer less hydrophobic and offering the pos
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Book chapters on the topic "Korsmeyer-Peppas model"

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Talevi, Alan, and María E. Ruiz. "Korsmeyer-Peppas, Peppas-Sahlin, and Brazel-Peppas: Models of Drug Release." In The ADME Encyclopedia. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51519-5_35-1.

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2

Bin Zafar Auniq, Reedwan, Namon Hirun, and Upsorn Boonyang. "Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release." In Ceramic Materials [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95290.

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Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.
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