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Journal articles on the topic 'Kpnb1'

Author: Grafiati

Published: 29 March 2025

Last updated: 31 July 2025

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1

Mihalas, Bettina P., Patrick S. Western, Kate L. Loveland, Eileen A. McLaughlin, and Janet E. Holt. "Changing expression and subcellular distribution of karyopherins during murine oogenesis." REPRODUCTION 150, no. 6 (2015): 485–96. http://dx.doi.org/10.1530/rep-14-0585.

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Mammalian oocyte growth and development is driven by a strict program of gene expression that relies on the timely presence of transcriptional regulators via nuclear pores. By targeting specific cargos for nucleo-cytoplasmic transport, karyopherin (KPN) proteins are key to the relocation of essential transcription factors and chromatin-remodelling factors into and out of the nucleus. Using multiple complementary techniques, here we establish that KPNA genes and proteins are dynamically expressed and relocalised throughout mouse oogenesis and folliculogenesis. Of the KPNAs examined (Kpna1, Kpna

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Sato, Kota, Hironori Yoshino, Yoshiaki Sato, Manabu Nakano та Eichi Tsuruga. "ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells". Current Issues in Molecular Biology 45, № 8 (2023): 6262–71. http://dx.doi.org/10.3390/cimb45080394.

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Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant cancer cells. Therefore, it is necessary to identify the underlying mechanisms of radioresistance in HNSCC. Previously, we showed that the inhibition of karyopherin-β1 (KPNB1), a factor in the nuclear transport system, enhances radiation-induced cytotoxicity, specifically in HNSCC cells, and decreases the localization of SCC-specific transcription factor ΔNp63. This suggests that ΔNp63 may be a KPNB1-carrying nucleoprotein that regulates

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3

Hazawa, Masaharu, Hironori Yoshino, Yuta Nakagawa та ін. "Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines". Cancers 12, № 4 (2020): 908. http://dx.doi.org/10.3390/cancers12040908.

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Nuclear transport receptors, such as karyopherin-β1 (KPNB1), play important roles in the nuclear-cytoplasmic transport of macromolecules. Recent evidence indicates the involvement of nuclear transport receptors in the progression of cancer, making these receptors promising targets for the treatment of cancer. Here, we investigated the anticancer effects of KPNB1 blockage or in combination with ionizing radiation on human head and neck squamous cell carcinoma (HNSCC). HNSCC cell line SAS and Ca9-22 cells were used in this study. Importazole, an inhibitor of KPNB1, or knockdown of KPNB1 by siRNA

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4

Kodama, Michiko, Takahiro Kodama, Justin Y. Newberg, et al. "In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer." Proceedings of the National Academy of Sciences 114, no. 35 (2017): E7301—E7310. http://dx.doi.org/10.1073/pnas.1705441114.

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Epithelial ovarian cancer (EOC) is a deadly cancer, and its prognosis has not been changed significantly during several decades. To seek new therapeutic targets for EOC, we performed an in vivo dropout screen in human tumor xenografts using a pooled shRNA library targeting thousands of druggable genes. Then, in follow-up studies, we performed a second screen using a genome-wide CRISPR/Cas9 library. These screens identified 10 high-confidence drug targets that included well-known oncogenes such as ERBB2 and RAF1, and novel oncogenes, notably KPNB1, which we investigated further. Genetic and pha

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Yoshino, Hironori, Yoshiaki Sato, and Manabu Nakano. "KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1." Current Issues in Molecular Biology 43, no. 1 (2021): 153–62. http://dx.doi.org/10.3390/cimb43010013.

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Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that negatively regulates anti-tumor immunity. Recent reports indicate that anti-cancer treatments, such as radiation therapy, increase PD-L1 expression on the surface of tumor cells. We previously reported that the nuclear transport receptor karyopherin-β1 (KPNB1) is involved in radiation-increased PD-L1 expression on head-and-neck squamous cell carcinoma cells. However, the mechanisms underlying KPNB1-mediated, radiation-increased PD-L1 expression remain unknown. Thus, the mechanisms of radiation-increased, KPNB1-mediated PD-

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Park, Chanhee, Jiwon Oh, Won Mo Lee та ін. "Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity". International Journal of Molecular Sciences 22, № 6 (2021): 2794. http://dx.doi.org/10.3390/ijms22062794.

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Background: Nuclear protein-1 (NUPR1, also known as p8/Com-1) is a transcription factor involved in the regulation of cellular stress responses, including serum starvation and drug stimulation. Methods: We investigated the mechanism of NUPR1 nuclear translocation involving karyopherin β1 (KPNB1), using a single-molecule binding assay and confocal microscopy. The cellular effects associated with NUPR1–KPNB1 inhibition were investigated by gene expression profiling and cell cycle analysis. Results: The single-molecule binding assay revealed that KPNB1 bound to NUPR1 with a binding affinity of 0.

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Zeng, Yan, Yuna Wang, Zhiqin Wu, et al. "miR-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B." American Journal of Physiology-Cell Physiology 308, no. 9 (2015): C720—C728. http://dx.doi.org/10.1152/ajpcell.00299.2014.

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The fast response to stimuli and subsequent activation of the nuclear factor of activated T cells (NFAT) signaling pathway play an essential role in human T cell functions. MicroRNAs (miRNAs) are increasingly implicated in regulation of numerous biological and pathological processes. In this study we demonstrate a novel function of miRNA-9 (miR-9) in regulation of the NFAT signaling pathway. Upon PMA-ionomycin stimulation, miR-9 was markedly increased, consistent with NFAT activation. Overexpression of miR-9 significantly enhanced NFAT activity and accelerated NFAT dephosphorylation and its nu

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8

Kim, Yong-Hak, Siyoung Ha, Jungwon Kim, and Seung Wook Ham. "Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity." ChemMedChem 11, no. 13 (2016): 1406–9. http://dx.doi.org/10.1002/cmdc.201600159.

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9

Zhu, Zhi-Chuan, Ji-Wei Liu, Kui Li, Jing Zheng, and Zhi-Qi Xiong. "KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells." Oncogene 37, no. 22 (2018): 2936–52. http://dx.doi.org/10.1038/s41388-018-0180-9.

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10

Zeng, Renya, and Jixin Dong. "Abstract 5491: Targeting importin-YAP axis in pancreatic ductal adenocarcinoma." Cancer Research 82, no. 12_Supplement (2022): 5491. http://dx.doi.org/10.1158/1538-7445.am2022-5491.

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Abstract Background: To date, pancreatic ductal adenocarcinoma (PDAC) remains to have a dismal prognosis, with a 5-year survival rate of only 10%, which brings out an imperative to develop new therapeutic strategies to improve patient outcome. Recently, aberrant nucleocytoplasmic transport machinery in cancer cells has emerged as a rational therapeutic target. We aim to validate the nuclear importin complex involved in the import of macromolecules across the nuclear membrane as a potential therapeutic target in PDAC. Methods: Tet-inducible shRNA and FDA-approved agent (Ivermectin) were used fo

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Sekimoto, Noboru, Yutaka Suzuki, and Sumio Sugano. "Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma." Journal of Cancer 8, no. 19 (2017): 4125–40. http://dx.doi.org/10.7150/jca.21802.

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12

Zhang, Pingyu, Jeannine Garnett, Chad J. Creighton, et al. "EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis." Journal of Pathology 232, no. 3 (2014): 308–18. http://dx.doi.org/10.1002/path.4294.

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13

Ha, Siyoung, Jiwon Oh, Ji Min Jang, Dae Kyong Kim, and Seung Wook Ham. "Synthesis and Biological Evaluation of 2-Aminothiazole Derivative Having Anticancer Activity as a KPNB1 Inhibitor." Bulletin of the Korean Chemical Society 37, no. 11 (2016): 1743–44. http://dx.doi.org/10.1002/bkcs.10968.

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14

Dai, Aihua, Xiaorong Liu, Yu Zhang, et al. "RETRACTED ARTICLE: Up-Regulation of KPNB1 Involves in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats." Neurochemical Research 40, no. 11 (2015): 2177–87. http://dx.doi.org/10.1007/s11064-015-1706-y.

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15

Liu, Jun‐Chao, Dong‐Fang Xue, Xiao‐Qian Wang, Deng‐Bin Ai та Pei‐Juan Qin. "MiR‐101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF‐κB signaling". Kaohsiung Journal of Medical Sciences 35, № 3 (2019): 139–45. http://dx.doi.org/10.1002/kjm2.12025.

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16

Wang, Teng, Zhenglan Huang, Ningshu Huang, et al. "Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1." OncoTargets and Therapy Volume 12 (December 2019): 10455–67. http://dx.doi.org/10.2147/ott.s210048.

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17

Stelma, Tamara, and Virna D. Leaner. "KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells." Oncotarget 8, no. 20 (2017): 32833–47. http://dx.doi.org/10.18632/oncotarget.15834.

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18

Dai, Aihua, Xiaorong Liu, Yu Zhang, et al. "Retraction Note to: Up-Regulation of KPNB1 Involves in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats." Neurochemical Research 41, no. 6 (2016): 1505. http://dx.doi.org/10.1007/s11064-016-1860-x.

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19

Zhang, Pingyu, Xianbin Yang, Xiaoyan Ma, et al. "Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway." Molecular Cancer 14, no. 1 (2015): 55. http://dx.doi.org/10.1186/s12943-015-0325-1.

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20

García-Cárdenas, Jennyfer M., Isaac Armendáriz-Castillo, Andy Pérez-Villa, et al. "Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins." Biology 11, no. 4 (2022): 481. http://dx.doi.org/10.3390/biology11040481.

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More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions of the cell should be investigated, such as post-transcriptional regulation. RNA-binding proteins (RBPs) are emerging as critical post-transcriptional modulators of tumorigenesis, but only a few have clear roles in BC. To recognize new putative breast cancer RNA-binding proteins, we performed integrated in silico analyses of all human RBPs (n = 1392) in three major cancer databases an

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21

Dong, Qiang, Xiang Li, Cheng-Zhi Wang, et al. "Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing." Proceedings of the National Academy of Sciences 115, no. 17 (2018): E4013—E4022. http://dx.doi.org/10.1073/pnas.1800505115.

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Epigenetic silencing can be mediated by various mechanisms, and many regulators remain to be identified. Here, we report a genome-wide siRNA screening to identify regulators essential for maintaining gene repression of a CMV promoter silenced by DNA methylation. We identified CSE1L (chromosome segregation 1 like) as an essential factor for the silencing of the reporter gene and many endogenous methylated genes. CSE1L depletion did not cause DNA demethylation. On the other hand, the methylated genes derepressed by CSE1L depletion largely overlapped with methylated genes that were also reactivat

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Schertzer, Michael, Laurent Jullien, André L. Pinto, Rodrigo T. Calado, Patrick Revy та Arturo Londoño-Vallejo. "Human RTEL1 Interacts with KPNB1 (Importin β) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase". Cells 12, № 24 (2023): 2798. http://dx.doi.org/10.3390/cells12242798.

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Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs. Here we show that RTEL1 deficiency leads to a nuclear envelope destabilization exclusively in cells entering S-phase and in direct connection to origin firing. We discovered that inhibiting protein import also leads to similar, albeit non-cell cycle-related, nuclear envelope disruptions. Remarkably, overexpression of wild-type RTEL1, or of its C-terminal part lacking the hel

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23

Wang, Lixin, Bishal Paudel, Anthony McKnight, and Kevin Janes. "Abstract 2565: Divergentnucleocytoplasmic transport influences escape from HER2-activated DCIS-like state." Cancer Research 83, no. 7_Supplement (2023): 2565. http://dx.doi.org/10.1158/1538-7445.am2023-2565.

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Abstract HER2/ErbB2 and EGFR/ErbB1 activation incite a phenotype resembling premalignant escape from ductal carcinoma in situ (DCIS) in the 3D multicellular arrangement of breast-epithelial cells. This phenomenon tends to be infrequent, and the exact mechanism for its heterogeneous presentation has been elusive. We sought to investigate the process by which ErbB receptors facilitate a picture of incomplete penetrance in DCIS escape (DE). To identify the transcriptional signatures that prime cells towards DE, we randomly profiled 10-cell transcriptomes of single spheroids after 24 hours of ERBB

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Segatori, Valeria Inés, Juan Garona, Lorena Grisel Caligiuri, et al. "Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients." Viruses 13, no. 10 (2021): 2084. http://dx.doi.org/10.3390/v13102084.

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Nuclear transport and vesicle trafficking are key cellular functions involved in the pathogenesis of RNA viruses. Among other pleiotropic effects on virus-infected host cells, ivermectin (IVM) inhibits nuclear transport mechanisms mediated by importins and atorvastatin (ATV) affects actin cytoskeleton-dependent trafficking controlled by Rho GTPases signaling. In this work, we first analyzed the response to infection in nasopharyngeal swabs from SARS-CoV-2-positive and -negative patients by assessing the gene expression of the respective host cell drug targets importins and Rho GTPases. COVID-1

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Wang, Jinglei, Hanying Chen, Yongsheng Zhang, Song Jiang, Xiancun Zeng, and Hong Shen. "Comprehensive Analysis of Differentially Expressed CircRNAs in the Ovaries of Low- and High-Fertility Sheep." Animals 13, no. 2 (2023): 236. http://dx.doi.org/10.3390/ani13020236.

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CircRNAs are essential in regulating follicle growth and development and the female reproductive system at multiple levels. However, the molecular mechanism by which circRNAs regulate reproduction in sheep is unclear and requires further exploration. In this study, RNA sequencing was performed to reveal the circRNA expression profiles in the ovaries of Cele black sheep and Hetian sheep during estrus. Analysis of the number of circRNAs in their host genes revealed that 5031 genes could produce 20,835 circRNAs. Among the differentially expressed circRNAs (DEcircRNA), 75 were upregulated, and 105

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Ye, Qing, and Nancy Lan Guo. "Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks." Biomolecules 12, no. 12 (2022): 1782. http://dx.doi.org/10.3390/biom12121782.

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There are currently no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). Novel therapeutic targets are needed to improve NSCLC survival outcomes. This study systematically evaluated the association between genome-scale regulatory network centralities and NSCLC tumorigenesis, proliferation, and survival in early-stage NSCLC patients. Boolean implication networks were used to construct multimodal networks using patient DNA copy number variation, mRNA, and protein expression profiles. T statistics of differential gene/protein expression in tumo

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Wang, Nianwu, Wei Wang, Wenli Mao, et al. "RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma." BioMed Research International 2021 (January 9, 2021): 1–21. http://dx.doi.org/10.1155/2021/6905985.

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Background. The majority of lung cancers are adenocarcinomas, with the proportion being 40%. The patients are mostly diagnosed in the middle and late stages with metastasis and easy recurrence, which poses great challenge to the treatment and prognosis. Platinum-based chemotherapy is a primary treatment for adenocarcinoma, which frequently causes drug resistance. As a result, it is important to uncover the mechanisms of the chemoresponse of adenocarcinoma to platinum-based chemotherapy. Methods. The genes from the dataset GSE7880 were gathered into gene modules with the assistance of weighted

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28

Zhen, Yan, Vigdis Sørensen, Camilla S. Skjerpen та ін. "Nuclear Import of Exogenous FGF1 Requires the ER-Protein LRRC59 and the Importins Kpnα1 and Kpnβ1". Traffic 13, № 5 (2012): 650–64. http://dx.doi.org/10.1111/j.1600-0854.2012.01341.x.

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Thiel, Cora Sandra, Swantje Christoffel, Svantje Tauber, et al. "Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation." International Journal of Molecular Sciences 21, no. 2 (2020): 514. http://dx.doi.org/10.3390/ijms21020514.

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Cellular processes are influenced in many ways by changes in gravitational force. In previous studies, we were able to demonstrate, in various cellular systems and research platforms that reactions and adaptation processes occur very rapidly after the onset of altered gravity. In this study we systematically compared differentially expressed gene transcript clusters (TCs) in human Jurkat T cells in microgravity provided by a suborbital ballistic rocket with vector-averaged gravity (vag) provided by a 2D clinostat. Additionally, we included 9× g centrifuge experiments and rigorous controls for

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30

Ayala-Madrigal, M. L., S. Doerr, M. L. Ramírez-Dueñas, and I. Hansmann. "Assignment¹ of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, by in situ hybridization." Cytogenetic and Genome Research 89, no. 3-4 (2000): 258–59. http://dx.doi.org/10.1159/000015627.

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31

Sakurai, Koki, Taichi Itou, Makiko Morita та ін. "Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice". PLOS ONE 16, № 11 (2021): e0258364. http://dx.doi.org/10.1371/journal.pone.0258364.

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Importin α1/KPNA1 is a member of the Importin α family widely present in the mammalian brain and has been characterized as a regulator of neuronal differentiation, synaptic functionality, and anxiety-like behavior. In humans, a de novo mutation of the KPNA1 (human Importin α5) gene has been linked with schizophrenia; however, the precise roles of KPNA1 in disorder-related behaviors are still unknown. Moreover, as recent studies have highlighted the importance of gene-environment interactions in the development of psychiatric disorders, we investigated the effects of Kpna1 deletion and social i

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32

Balcão, Victor M., Fernanda C. Moreli, Erica C. Silva, et al. "Isolation and Molecular Characterization of a Novel Lytic Bacteriophage That Inactivates MDR Klebsiella pneumoniae Strains." Pharmaceutics 14, no. 7 (2022): 1421. http://dx.doi.org/10.3390/pharmaceutics14071421.

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The worldwide increase in serious infections caused by multidrug-resistant (MDR) K. pneumoniae emphasizes the urgent need of new therapeutic strategies for the control of this pathogen. There is growing interest in the use of bacteriophages (or phages) to treat K. pneumoniae infections, and newly isolated phages are needed. Here, we report the isolation and physical/biological/molecular characterization of a novel lytic phage and its efficacy in the control of MDR K. pneumoniae. The phage vB_KpnS_Uniso31, referred to hereafter as phage Kpn31, was isolated from hospital wastewater using K. pneu

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Jones, Jessica M., Carrie Simkus, and Anamika Bhattacharyya. "KPNA1 is a putative substrate of the RAG1 ubiquitin ligase (138.11)." Journal of Immunology 182, no. 1_Supplement (2009): 138.11. http://dx.doi.org/10.4049/jimmunol.182.supp.138.11.

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Abstract The RAG1 V(D)J recombinase encompasses DNA binding/cleavage and ubiquitin ligase activities. The nuclear transport protein karyopherin alpha 1 (KPNA1) binds to RAG1 upstream of its ubiquitin ligase domain, but this interaction is not required for nuclear localization of RAG1. We found that the isolated ubiquitin ligase domain of RAG1 (amino acids 218-389) promoted ubiquitylation of purified KPNA1 in a reaction supported by the ubiquitin conjugating (E2) enzyme UbcH2/Rad6 or UbcH5a. KPNA1 is the first putative substrate identified for the RAG1 ubiquitin ligase. Ubiquitylation of KPNA1

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Spruit, Cindy M., Anu Wicklund, Xing Wan, Mikael Skurnik, and Maria I. Pajunen. "Discovery of Three Toxic Proteins of Klebsiella Phage fHe-Kpn01." Viruses 12, no. 5 (2020): 544. http://dx.doi.org/10.3390/v12050544.

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The lytic phage, fHe-Kpn01 was isolated from sewage water using an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae as a host. The genome is 43,329 bp in size and contains direct terminal repeats of 222 bp. The genome contains 56 predicted genes, of which proteomics analysis detected 29 different proteins in purified phage particles. Comparison of fHe-Kpn01 to other phages, both morphologically and genetically, indicated that the phage belongs to the family Podoviridae and genus Drulisvirus. Because fHe-Kpn01 is strictly lytic and does not carry any known resistance o

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Nomiya, Hirotaka, and Masami Yamada. "Interactions between genetic and environmental factors and schizophrenia: Insights from KPNA1-deficient mice." Journal of Neurology & Neuromedicine 8, no. 2 (2024): 1–2. http://dx.doi.org/10.29245/2572.942x/2024/2.1299.

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The interactions between genetic and environmental factors (G x E interactions) play a crucial role in the pathogenesis of schizophrenia. The administration of phencyclidine, a psychotropic drug, to Kpna1-deficient mice induces behavioral abnormalities resembling schizophrenia. In the nucleus accumbens of these mice, the expressions of dopamine receptors, an RNA editing enzyme, and cytoplasmic dynein demonstrate gene-environment interaction-dependent alterations. Kpna1-deficient mice may be useful as a gene-environment interaction model for schizophrenia and provide insights into its pathogene

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Wang, X., L. Magnani, and R. Cabot. "198 KARYOPHERIN ALPHA EXPRESSION IN PORCINE OOCYTES AND EMBRYOS PRODUCED BY IN VITRO FERTILIZATION." Reproduction, Fertility and Development 21, no. 1 (2009): 197. http://dx.doi.org/10.1071/rdv21n1ab198.

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Partitioning intracellular proteins between nuclear and cytoplasmic compartments is critically important for coordinating major cellular events involved in transcription and differentiation. Import of cytoplasmic proteins bearing classical nuclear localization signals (NLSs) into the nucleus is mediated by the importin α/β heterodimer. Importin α, also called karyopherin α (KPNA), serves to recognize the NLS-bearing cytoplasmic cargo. Six KPNA molecules have been characterized in human (KPNA1-6). Select KPNA molecules are known to be differently expressed in specific tissues; individual KPNA m

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Wei, Jun, and Gwynneth P. Hemmings. "The KPNB3 locus is associated with schizophrenia." Neuroscience Letters 368, no. 3 (2004): 323–26. http://dx.doi.org/10.1016/j.neulet.2004.07.049.

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Wang, Huanru, Meng Yuan, Shuaibo Wang, et al. "STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1." International Journal of Molecular Sciences 20, no. 19 (2019): 4870. http://dx.doi.org/10.3390/ijms20194870.

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Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates inflammation and immunity. Knowledge of its regulatory mechanisms is very limited. Here, we showed that enterovirus 71 (EV71) infection induced the phosphorylation of STAT3 and the expression of its downstream inflammatory regulators. Knockdown of STAT3 with siRNAs significantly restricted viral RNA and protein levels, and also reduced viral titers. With further investigation, we found that importin α family member Karyopherin-α1 (KPNA1) was employed by both STAT1 and STAT3 for their nuclear i

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39

Holubec, Johannes. "Neue Dimension für die Online-Prozesskontrolle." Wochenblatt für Papierfabrikation 152, no. 6-7 (2024): 29–33. http://dx.doi.org/10.51202/0043-7131-2024-6-7-029.

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Die Firma Pixact wurde im Jahr 2006 aus universitärem Umfeld in Tampere gegründet und hat sich mittlerweile zu einem weltweit agierenden Unternehmen, mit über 200 installierten Systemen plus 200 Messkampanien, etabliert. Autor: Johannes Holubec, KPNB

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Holubec, Johannes. "Neue Dimension für die Online-Prozesskontrolle." Wochenblatt für Papierfabrikation 152, no. 6 (2024): 29–33. http://dx.doi.org/10.51202/0043-7131-2024-6-029.

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Die Firma Pixact wurde im Jahr 2006 aus universitärem Umfeld in Tampere gegründet und hat sich mittlerweile zu einem weltweit agierenden Unternehmen, mit über 200 installierten Systemen plus 200 Messkampanien, etabliert. Autor: Johannes Holubec, KPNB

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Buschmeier, Nicole, and Donato Cristaldi. "Rückgewinnung von Energie und Wasser." Wochenblatt für Papierfabrikation 152, no. 6-7 (2024): 38–39. http://dx.doi.org/10.51202/0043-7131-2024-6-7-038.

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Die Anaergia Technologies ist Tochter der Anaergia Gruppe mit Sitz in Kanada, einem der Weltmarktführer in der Rückgewinnung von Organik zur Erzeugung von Energie, Wasser und Düngemittel aus nahezu jedem Abfallstrom. Autoren: Nicole Buschmeier, KPNB; Donato Cristaldi, Geschäftsführer Anaergia Technologies GmbH

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Buschmeier, Nicole, and Donato Cristaldi. "Rückgewinnung von Energie und Wasser." Wochenblatt für Papierfabrikation 152, no. 6 (2024): 38–39. http://dx.doi.org/10.51202/0043-7131-2024-6-038.

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Die Anaergia Technologies ist Tochter der Anaergia Gruppe mit Sitz in Kanada, einem der Weltmarktführer in der Rückgewinnung von Organik zur Erzeugung von Energie, Wasser und Düngemittel aus nahezu jedem Abfallstrom. Autoren: Nicole Buschmeier, KPNB; Donato Cristaldi, Geschäftsführer Anaergia Technologies GmbH

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Buschmeier, Nicole. "Qualitätsseile seit 1949." Wochenblatt für Papierfabrikation 152, no. 6-7 (2024): 40–42. http://dx.doi.org/10.51202/0043-7131-2024-6-7-040.

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Lanex a.s. ist tschechischer Hersteller von Qualitätsseilen und ein zuverlässiger Geschäftspartner mit langer Tradition – die ersten Seile wurden in Bolatice bereits im Jahre 1949 hergestellt. Heute stellt Lanex nicht nur Seile und Fasern her, sondern entwickeln sie auch selbst. Autorin: Nicole Buschmeier, KPNB

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44

Buschmeier, Nicole. "Qualitätsseile seit 1949." Wochenblatt für Papierfabrikation 152, no. 6 (2024): 40–42. http://dx.doi.org/10.51202/0043-7131-2024-6-040.

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Abstract:

Lanex a.s. ist tschechischer Hersteller von Qualitätsseilen und ein zuverlässiger Geschäftspartner mit langer Tradition – die ersten Seile wurden in Bolatice bereits im Jahre 1949 hergestellt. Heute stellt Lanex nicht nur Seile und Fasern her, sondern entwickeln sie auch selbst. Autorin: Nicole Buschmeier, KPNB

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45

Kallioranta, Annely, and Nicole Buschmeier. "Qualitätsleitsysteme für die Papierindustrie." Wochenblatt für Papierfabrikation 152, no. 6-7 (2024): 26–28. http://dx.doi.org/10.51202/0043-7131-2024-6-7-026.

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Tasowheel ist ein finnisches Familienunternehmen, das 1979 gegründet wurde und sich auf schlüsselfertige QLS-Projekte für Papierherstelleung und Papierverarbeitung spezialisiert hat. Das Unternehmen ist ein unabhängiger Originalhersteller mit agilen und flexiblen Abläufen, der wettbewerbsfähige Produkte anbietet. Autoren: Annely Kallioranta,Tasowheel Oy; Nicole Buschmeier, KPNB

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46

Kallioranta, Annely, and Nicole Buschmeier. "Qualitätsleitsysteme für die Papierindustrie." Wochenblatt für Papierfabrikation 152, no. 6 (2024): 26–28. http://dx.doi.org/10.51202/0043-7131-2024-6-026.

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Abstract:

Tasowheel ist ein finnisches Familienunternehmen, das 1979 gegründet wurde und sich auf schlüsselfertige QLS-Projekte für Papierherstelleung und Papierverarbeitung spezialisiert hat. Das Unternehmen ist ein unabhängiger Originalhersteller mit agilen und flexiblen Abläufen, der wettbewerbsfähige Produkte anbietet. Autoren: Annely Kallioranta,Tasowheel Oy; Nicole Buschmeier, KPNB

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47

Valinluck, Boontar, Nan Sook Lee, and Junichi Ryu. "A new restriction-modification system, KpnBI, recognized in Klebsiella pneumoniae." Gene 167, no. 1-2 (1995): 59–62. http://dx.doi.org/10.1016/0378-1119(95)00660-5.

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van der Watt, Pauline J., Alicia Chi, Tamara Stelma та ін. "Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic". Molecular Cancer Therapeutics 15, № 4 (2016): 560–73. http://dx.doi.org/10.1158/1535-7163.mct-15-0052.

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Nakanishi, Anna, Hiroki Okumura, Tadahiro Hashita, et al. "Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2." Viruses 14, no. 11 (2022): 2468. http://dx.doi.org/10.3390/v14112468.

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Hepatitis B virus (HBV) specifically infects human hepatocytes and increases the risks of cirrhosis and liver cancer. Currently, nucleic acid analogs are the main therapeutics for chronic hepatitis caused by HBV infection. Although nucleic acid analogs can eliminate HBV DNA by inhibiting HBV reverse transcriptase, they cannot lead to negative conversion of covalently closed circular DNA (cccDNA) and hepatitis B surface antigen (HBsAg). In this study, we revealed that the antifilarial drug ivermectin suppresses HBV production by a different mechanism from the nucleic acid analog entecavir or Na

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Cohen, Yael C., Mor Zada, Shuang-Yin Wang, et al. "Single Cell RNA Sequencing in Patients Enrolled in a Selinexor Clinical Trial Reveals Overexpression of Alternative Nuclear Export Pathways Associated with Resistance to Selinexor in Refractory Multiple Myeloma." Blood 138, Supplement 1 (2021): 2725. http://dx.doi.org/10.1182/blood-2021-149701.

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Abstract Selinexor is a novel, first-in-class oral selective inhibitor of nuclear export which blocks Exportin 1 (XPO1), forcing the nuclear retention and activation of tumor suppressor proteins, ultimately causing apoptosis in cancer cells. Selinexor has been approved for the treatment of patients with penta-refractory multiple myeloma (MM) who have received at least 4 prior therapies. We previously reported the discovery of a novel transcriptional signature and therapeutic targets for therapy resistant MM by comprehensive single cell RNA-seq analysis (scRNA-seq) of plasma cells (PCs) in pati

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