Academic literature on the topic 'Kral y Ma'

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Journal articles on the topic "Kral y Ma"

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Maroli, Sree Lakshmi Velandi, Roman E. Reggiardo, Reem Khojah, and Daniel H. Kim. "Abstract LB_B21: Extracellular RNA signatures of mutant KRAS-driven lung cancer." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): LB_B21. http://dx.doi.org/10.1158/1535-7163.targ-23-lb_b21.

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Abstract RAS genes are the most frequently mutated oncogenes in cancer, yet the effects of oncogenic RAS signaling on the noncoding transcriptome remain unclear. We analyzed the transcriptomes of human airway and bronchial epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulated noncoding RNAs. We find that oncogenic KRAS signaling upregulates noncoding transcripts throughout the genome, many of which arise from transposable elements (TEs). These TE RNAs exhibit differential expression and are regulated by KRAB zinc-finger (KZNF) genes, which are broadly downregu
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Ben-Ammar, Imen, Michel Ducreux, Valérie Boige, et al. "KRAS WT pancreatic adenocarcinomas: Another disease?" Journal of Clinical Oncology 41, no. 4_suppl (2023): 750. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.750.

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750 Background: KRAS mutation is the most common molecular alteration (MA) in pancreatic adenocarcinoma (PDAC), and only 8-10% of patients (pts) harbor KRAS wild-type tumors (WT). This study describes clinical and molecular features of KRAS WT PDAC and compares it to mutant KRAS (m KRAS) PDAC. Methods: A retrospective chart review of clinical/molecular data was performed on all pts with PDAC who had contributive molecular profile at Gustave Roussy. KRAS status was determined on tumor molecular profiling as part of routine care using an in-house panel or Foundation Medicine NGS either on tissue
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Al- Islamiyah, Suwaibah, and Diah Sudiarti. "Meningkatkan Hasil Belajar Siswa melalui Model Pembelajaran Inquiry dengan Menggunakan Metode Eksperimen pada Pokok Bahasan Pencemaran Lingkungan Kelas X (Putri) Tahun Pelajaran 2016/2017." JURNAL BIOSHELL 8, no. 2 (2021): 65–69. http://dx.doi.org/10.36835/bio.v8i2.919.

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Penelitian merupakan kegiatan utama dari proses pendidikan. Peneliti melakukan penelitian di kelas X (putri) MA Bustanul Ulum Krai-Yosowilangun-Lumajang dengan responden yang diteliti sebanyak 19 siswa Putri. Peneliti melakukan observasi di kelas X (putri) MA Bustanul Ulum Krai-Yosowilangun dan diperoleh data sekitar 75 % menunjukkan nilai siswa ≤70. Prosedur yang digunakan adalah model siklus berdasarkan hasil penelitian, persentase hasil belajar pada siklus I mencapai 38,131 dan siklus II mencapai hingga 44,605 sedangkan untuk melihat persentase hasil belajar siklus I mencapai 68,421% dan si
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Yang, Liu, Yue Cai, Jianwei Zhang, et al. "Colorectal cancer with mucinous component compared to clinicopathological and molecular features as mucinous adenocarcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15166-e15166. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15166.

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e15166 Background: CRC can be divided into 3 groups: regular adenocarcinoma (RA), mucinous adenocarcinoma (MA), and adenocarcinoma with mucinous component (MC, mucin formation <50 % ). MA is distinct from RA, however, little is known about MC. We aimed to compare the clinicopathological and genetic features of 3 groups. Methods: A retrospective chort of consecutive CRC patients with available gene status was enrolled. KRAS,NRAS,BRAF,PIK3CA gene, MSI(IHC method) status were analyzed. Results: A total of 1454 patients were enrolled, including 1179 RA, 106 MA and 169 MC. Similar to MA, MC pati
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Nurindah Lailatul Fitriana, Leni, and Muawanah. "IMPLEMENTASI KURIKULUM DARURAT COVID-19 DI MA HIDAYATUL HUSNA BUTUH KRAS KEDIRI." Al-Hasanah : Jurnal Pendidikan Agama Islam 7, no. 2 (2022): 222–44. http://dx.doi.org/10.51729/7274.

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Masa pandemi yang terjadi pada tahun 2020 akibat merebaknya virus Covid-19 telah mengancam di berbagai dunia, terutama di wilayah Indonesia. Menyebabkan perubahan yang besar dalam tatanan kehidupan, kondisi sosial tidak terkecuali pada dunia pendidikan. Program-program yang telah dirancang oleh satuan pendidikan sebagai panduan dalam pelaksanaan kegiatan pembelajar, mau tidak mau harus berubah. Dengan kondisi pandemi covid-19, pemerintah juga mengeluarkan instrukti yaitu melarang masyarakat untuk melakukan aktivitas berkerumun dan kegiatan yang mendatangkan masa. Sehingga hal tersebut berdampa
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Rodriguez Freixinos, Victor, Fiorella Ruiz-Pace, Lorena Fariñas-Madrid, et al. "Impact of genomic heterogeneity on PI3K/AKT/mTOR inhibitors (PAMi) efficacy in gynecologic cancer (GYN) patients (pts)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5569. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5569.

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5569 Background: Aberrant PI3K/AKT/mTOR activation is common in GYN. Predictive biomarkers to PAMi in GYN have yet to be identified. Methods: Advanced GYN pts with available genomic data, treated with PAMi in phase I/II clinical trials were selected. Mutation (mut) allele fractions (MAFs) were corrected for tumor purity and defined as clonal (cl) (≥ 0.4) or subclonal (scl) ( < 0.4). PAMi efficacy: (i) time to progression (TTP); (ii) clinical benefit rate (CBR: complete/partial response or stable disease > 4 months [m]); and (iii) ratio TTP on PAMi/ TTP on non-standard chemotherapy pre- o
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Łonyszyn, Przemysław. "Kraj Basków – sytuacja gospodarcza i polityka rozwoju." Rozwój Regionalny i Polityka Regionalna, no. 20 (August 30, 2012): 21–36. https://doi.org/10.14746/rrpr.2012.20.04.

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Gdy w Polsce lansuje się obraz gospodarki Kraju Basków jako modelowej, okazuje się, że niewiele o niej wiadomo. Niniejszy artykuł ma na celu prezentację i analizę fenomenu baskijskiej ekonomii, która łącząc tradycję i nowoczesność, potrafiła poradzić sobie ze światowym kryzysem, stając się prawdziwą „zieloną wyspą” na terenie Królestwa Hiszpanii z bezrobociem najniższym w kraju. Przedstawiono podstawowe filary (spółdzielczość, parki technologiczne, klastry), na których Baskowie oparli swój rozwój gospodarczy, a także plany międzysektorowego rozwoju.
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Kouznetsova, Ekaterina, Lauren McCauley, Elaine Steinke-Neal, et al. "Abstract 2987: A versatile assay suite for the discovery of new KRAS pathway inhibitors." Cancer Research 82, no. 12_Supplement (2022): 2987. http://dx.doi.org/10.1158/1538-7445.am2022-2987.

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Abstract The small GTPase, KRAS, is a known oncogene and a desirable drug target due to prevalence of mutations with poor disease prognosis. The absence of good druggable binding pockets has made modulator compound discovery challenging and unsuccessful. Identification of new inhibitor target sites has led to the resurgence of interest in KRAS drug discovery. To facilitate drug discovery activities targeting KRAS/MAPK pathway, we have produced the full spectrum of pathway proteins including kinases, wild type and mutated KRAS, guanine nucleotide exchange factor and effectors. This poster will
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Smolenschi, Cristina, Marine Valery, Alice Boileve, et al. "Is liquid biopsy useful in patients with GI malignancies and exclusive peritoneal disease?" Journal of Clinical Oncology 41, no. 4_suppl (2023): 809. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.809.

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809 Background: Peritoneal carcinomatosis (PC) is a common manifestation in gastro-intestinal (GI) cancers.10-20 % of patients (pts) will present isolated, unresectable peritoneal disease with poor prognosis. In the past years, circulating tumor DNA (ctDNA) has emerged as a novel and less invasive biomarker for molecular diagnosis and disease monitoring. We aimed to evaluate the ability of PC to shed ctDNA into circulation in a cohort of pts with GI cancers and isolated PC treated in our institution. Methods: We reviewed retrospectively the results of liquid biopsies obtained at progression or
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Goldstein, Daniel A., Julia Andrea Elvin, Kai Wang, et al. "Comprehensive genomic profiling of cancer of the appendix to reveal new routes to targeted therapies." Journal of Clinical Oncology 33, no. 3_suppl (2015): 608. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.608.

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608 Background: Cancers of the appendix are rare forms of malignancy that include two major mucin producing tumors, mucinous adenocarcinoma (MA) and goblet cell carcinoid (GCC). There is no clear standard of care for management of these malignancies. We queried whether comprehensive genomic profiling (CGP) of MA and GCC would reveal differences in the pattern of genomic alterations (GA) of these two subtypes of appendiceal cancer and serve as a guide for targeted therapies for this disease. Methods: DNA was extracted from 40 microns of FFPE sections from 20 clinically advanced appendiceal carc
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Dissertations / Theses on the topic "Kral y Ma"

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Brandt, Lisa. "Utvärdering av effektkartläggning med MA/SIMM : Effektkartläggning som stöd vid val av teknik för att nå önskad effekt vid utveckling av ett mobilt intranät." Thesis, Högskolan Dalarna, Informatik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:du-22592.

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Kravinsamling görs inför ett systemutvecklingsprojekt för att identifiera användarnas behov och önskade effekter med systemet. Ett problem för många system är att valet av teknik påverkas allt för mycket av vilka tekniker som finns i företaget och är i många fall förutbestämt, istället för att baseras på behov och krav som ställs på systemet. Effektkartläggning är en metod som kan användas för kravinsamling, men metoden har inte fokus på tekniska funktioner. Eftersom tekniken ofta är förutbestämd måste den beaktas redan under kravinsamlingen. Frågan är därför hur man kan använda effektkartlägg
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Books on the topic "Kral y Ma"

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ʼAcbarrahim, Muhammad. Chuʺ kraʺ mha pvanʻʹ so nhanʻʹ chi panʻʺ myaʺ: Kanʻʹ bha lu mruiʹ Mran ma ʼArabi sippam kyonʻʺ to kriʺ e* panna reʺ mrac phyaʺ kham la pum sa muinʻʺ nhanʹ tuiʺ vheʹ r* van la so nok chak tvai sa muinʻʺ. Mran ma ʼArabi Sippam kyonʻʺ, 2005.

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Book chapters on the topic "Kral y Ma"

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Marx, Agnieszka. "Krall, Hanna: Tam już nie ma żadnej rzeki." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_749-1.

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Wierzejski, Eryk. "Rosnąca obecność Chińskiej Republiki Ludowej na Bliskim Wschodzie w XXI wieku." In Vade Nobiscum, tom XXIV/2024. Wydawnictwo Uniwersytetu Łódzkiego, 2024. https://doi.org/10.18778/8331-610-9.07.

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Chińska Republika Ludowa jako kraj aspirujący do roli wiodącego supermocarstwa w multilateralnym świecie intensyfikuje swoją obecność międzynarodową w każdym regionie świata. Dojście do władzy Xi Jinpinga kończy erę doktryny 28 znaków Denga Xiaopinga polegającej na „ukrywaniu własnych możliwości”. Zmiana władzy rozpoczyna erę chińskiego marzenia, które do 2049 r. ma zaowocować wielkim chińskim renesansem. Odrodzone mają być państwem determinującym politykę międzynarodową. Region Bliskiego Wschodu w ciągu ostatnich dekad stał się kluczowym obszarem w polityce ChRL. Region ma znaczenie dla Pekin
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Conference papers on the topic "Kral y Ma"

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Kirkpatrick, D. Lynn, Roisin Delaney, Geoff Grandjean, et al. "Abstract C131: ‘KRAS addiction’ an artifact of 2D culture? Inhibitors of the mut-KRAS NSCLC 3D growth." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c131.

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Chattopadhyay, Nibedita, Allison Berger, James Garnsey, et al. "Abstract B156: Regulation of tumor metabolism by the investigational proteasome inhibitor ixazomib in KRAS wild-type and KRAS mutant xenograft tumors." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-b156.

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Hofmann, Marco H., Michael Gmachl, Jürgen Ramharter, et al. "Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-c133.

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Jänne, Pasi A. "Abstract PL04-02: Targeting MEK in KRAS mutant lung cancer." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-pl04-02.

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Dunn, Emily F., Mari Iida, Eric Armstrong, and Deric L. Wheeler. "Abstract C43: Dasatinib resensitizes Kras mutant colorectal tumors to cetuximab." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c43.

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Hofmann, Marco H., Michael Gmachl, Jürgen Ramharter, et al. "Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-pl06-01.

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Lloyd, George Kenneth, Lihua Du, Gloria Lee, et al. "Abstract A184: Activity of plinabulin in tumor models with Kras mutations." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-a184.

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Wang, I.-Ching, Hsin Chih Chien, Sheng-Yang Chao, and Chien-Cheng Li. "Abstract A44: Inhibition of Foxm1 transcription factor diminished Kras-mutated tumor development." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-a44.

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Velez-Delgado, Ashley, Valerie Irizarry-Negron, Rosa Menjivar, et al. "Abstract A54: Oncogenic Kras modulates pancreas plasticity and the tumor microenvironment." In Abstracts: AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; September 6-9, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.panca19-a54.

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Yao, Wantong, Haoqiang Ying, and Giulio Draetta. "Abstract C157: Syndecan1 is required for oncogenic Kras-driven PDAC tumorigenesis and maintenance." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c157.

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