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Journal articles on the topic 'KTGS'

Author: Grafiati

Published: 29 April 2022

Last updated: 30 July 2025

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1

BAR-NATAN, DROR, and ZSUZSANNA DANCSO. "HOMOMORPHIC EXPANSIONS FOR KNOTTED TRIVALENT GRAPHS." Journal of Knot Theory and Its Ramifications 22, no. 01 (2013): 1250137. http://dx.doi.org/10.1142/s0218216512501374.

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It had been known since old times (works of Murakami–Ohtsuki, Cheptea–Le and the second author) that there exists a universal finite type invariant ("an expansion") Z old for knotted trivalent graphs (KTGs), and that it can be chosen to intertwine between some of the standard operations on KTGs and their chord-diagrammatic counterparts (so that relative to those operations, it is "homomorphic"). Yet perhaps the most important operation on KTGs is the "edge unzip" operation, and while the behavior of Z old under edge unzip is well understood, it is not plainly homomorphic as some "correction fa

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Santi, Nicolò, Alessandra Piccirilli, Federico Corsini та ін. "Discovery of Boronic Acids-Based β-Lactamase Inhibitors Through In Situ Click Chemistry". International Journal of Molecular Sciences 26, № 9 (2025): 4182. https://doi.org/10.3390/ijms26094182.

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In this study, we evaluated in situ click chemistry as a platform for discovering boronic acid-based β-lactamase inhibitors (BLIs). Unlike conventional drug discovery approaches requiring multi-step synthesis, protection strategies, and extensive screening, the in situ method can allow for the generation and identification of potent β-lactamase inhibitors in a rapid, economic, and efficient way. Using KPC-2 (class A carbapenemase) and AmpC (class C cephalosporinase) as templates, we demonstrated their ability to catalyse azide-alkyne cycloaddition, facilitating the formation of triazole-based

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Lee, Dan-Bi, Hye-Yeong Chun, Soo-Hyun Kim, Robert D. Sharman, and Jung-Hoon Kim. "Development and Evaluation of Global Korean Aviation Turbulence Forecast Systems Based on an Operational Numerical Weather Prediction Model and In Situ Flight Turbulence Observation Data." Weather and Forecasting 37, no. 3 (2022): 371–92. http://dx.doi.org/10.1175/waf-d-21-0095.1.

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Abstract A global Korean deterministic aviation turbulence guidance (G-KTG) system and a global Korean probabilistic turbulence forecast (G-KPT) system are developed using outputs from the operational Global Data Assimilation and Prediction System of the Korea Meteorological Administration, and the performance skill of the systems are evaluated against in situ flight eddy dissipation rates (EDRs) recorded for one year (September 2018–August 2019). G-KTG and G-KPT consider clear-air turbulence (CAT) and mountain wave turbulence diagnostics, while G-KTG additionally considers near-cloud turbulen

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Mensah, Afua Adjeiwaa, Christos M. Chatzigiannis, Dimitrios A. Diamantis, et al. "Abstract 3942: Novel BCL2 inhibitors with anti-lymphoma activity." Cancer Research 82, no. 12_Supplement (2022): 3942. http://dx.doi.org/10.1158/1538-7445.am2022-3942.

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Abstract Background: Diffuse large B cell lymphomas (DLBCLs) are aggressive tumors that account for almost half of all lymphoma incidences. In particular, double-hit and triple-hit DLBCLs, with translocations involving BCL2, MYC and/or BCL6, have a very poor prognosis and occur in up to 7% of cases. Double expressor DLBCLs, with overexpression of BCL2 and MYC in the absence of chromosomal translocations, also have a poor prognosis. BCL2 inhibitors (BCL2i) have shown preclinical and clinical efficacy in lymphomas. Here, we synthesized and tested seven novel BCL2i in DLBCL cells with deregulated

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Laneuville, Laurence, Fabian Ballesteros, Aliya Affdal, et al. "Perspectives of Kidney Transplant Recipients, Transplant Candidates, and Living Kidney Donors on the Role of Patients’ Self-Narratives and Experiences of Creative Writing Workshops: A Qualitative Study." Canadian Journal of Kidney Health and Disease 9 (January 2022): 205435812211327. http://dx.doi.org/10.1177/20543581221132742.

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Background: Kidney transplantation is the best treatment for kidney failure but is associated with medical, psychological, and existential challenges for patients. Patients’ experiential knowledge can help other patients facing these challenges. Patients’ self-narratives and creative writings are ways to operationalize this experiential knowledge. Creative writing has been described as a therapeutic tool for patients with chronic disease. Over the past year, we conducted creative writing workshops with kidney transplant recipients (KTRs), living kidney donors (LKDs), kidney transplant candidat

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Star, Ava, Christine E. Fuller, and Steve K. Landas. "Intracranial Aneurysms in Klippel-Trenaunay/Weber Syndromes." Neurosurgery 66, no. 5 (2010): E1027—E1028. http://dx.doi.org/10.1227/01.neu.0000368392.69904.be.

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Abstract OBJECTIVE We present a comprehensive review of intracranial aneurysms in Klippel-Trenaunay and Klippel-Trenaunay-Weber syndromes (KTS/KTWS), and examine factors influencing the risks of surgery vs conservative management. CLINICAL PRESENTATION A 58-year-old physician with KTS affecting the right extremities presented with left hemispheric cerebellar stroke and was discovered to harbor four intracranial aneurysms of the posterior circulation: fusiform mid and distal BA (2.6 × 2 × 2 cm), fusiform right proximal P1 (2 × 1.3 × 1.3 cm), fusiform right distal P1 (2.8 × 2.7 × 2 cm), and sacc

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Slabe, Damjan, Rok Fink, Eva Dolenc, and Andreja Kvas. "Knowledge of health principles among professionals in Slovenian kindergartens." Slovenian Journal of Public Health 55, no. 3 (2016): 185–94. http://dx.doi.org/10.1515/sjph-2016-0024.

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Abstract Objectives Preschool children have significant health issues. From the relevant legislation and regulations, it can be seen that kindergarten teachers (KTs) and kindergarten teacher assistants (KTAs) are expected to be familiarwith the basic hygienic measures and steps for preventing injuries and illnesses, to recognize infectious diseases, and to know how to give the first aid. To gain these skills, a continuous life-long learning is necessary, because the characteristics of diseases are changing. Study design: original research. Methods 45 kindergartens in Slovenia were randomly sel

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Bonvicini, Simona, Marco Buratti, Martino Garonzi, Gloria Rinaldi, and Tommaso Traetta. "The first families of highly symmetric Kirkman Triple Systems whose orders fill a congruence class." Designs, Codes and Cryptography 89, no. 12 (2021): 2725–57. http://dx.doi.org/10.1007/s10623-021-00952-x.

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AbstractKirkman triple systems (KTSs) are among the most popular combinatorial designs and their existence has been settled a long time ago. Yet, in comparison with Steiner triple systems, little is known about their automorphism groups. In particular, there is no known congruence class representing the orders of a KTS with a number of automorphisms at least close to the number of points. We partially fill this gap by proving that whenever $$v \equiv 39$$ v ≡ 39 (mod 72), or $$v \equiv 4^e48 + 3$$ v ≡ 4 e 48 + 3 (mod $$4^e96$$ 4 e 96 ) and $$e \ge 0$$ e ≥ 0 , there exists a KTS on v points hav

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Shu, Chin-Chung, Meng-Kun Tsai, Shu-Wen Lin, Jann-Yuan Wang, Chong-Jen Yu, and Chih-Yuan Lee. "Latent Tuberculosis Infection Increases in Kidney Transplantation Recipients Compared With Transplantation Candidates: A Neglected Perspective in Tuberculosis Control." Clinical Infectious Diseases 71, no. 4 (2020): 914–23. http://dx.doi.org/10.1093/cid/ciz851.

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Abstract Background The prevalence and incidence of latent tuberculosis infection (LTBI) in patients with kidney transplantation remain unclear. Methods In this prospective study, we enrolled kidney transplantation candidates (KTCs) and recipients (KTRs) from 2014 to 2018. We defined LTBI as a positive result of QuantiFERON-TB Gold In-tube (QFT). We analyzed the predictors for LTBI acquisition and followed up on QFT assay test for 2 years among those initially without LTBI. Results Of 425 patients enrolled, 305 (71.8%) patients belonged to the KTC group and 120 (28.2%) to the KTR group. The in

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Duân, Nguyễn Văn, Lê Văn Cường, Karen Wylie та Lindy McAllister. "Khảo sát việc tự khắc phục và tìm kiếm hỗ trợ của gia đình có trẻ mắc khuyết tật giao tiếp ở khu vực nông thôn tỉnh Quảng Nam". TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG, ĐẶC BIỆT (24 грудня 2022): 302–9. http://dx.doi.org/10.59294/hiujs.vol..2022.396.

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Mục tiêu: Tìm hiểu những trải nghiệm của phụ huynh có con mắc khuyết tật giao tiếp (KTGT) tại khu vực nông thôn tỉnh Quảng Nam. Phương pháp nghiên cứu: Mô tả định tính. Kết quả: Chúng tôi đã ghi nhận 12 dấu hiệu xuất hiện ở trẻ khiến phụ huynh lo lắng về tình trạng giao tiếp của con họ. Về các hành động tự khắc phục, các khách thể khảo sát (KTKS) đã ưu tiên chọn các chiến lược giao tiếp, phương pháp giảng dạy cụ thể. Bên cạnh đó họ cũng đã áp dụng các biện pháp như hạn chế sử dụng ti vi, điện thoại thông minh hay thay đổi môi trường để giúp con họ cải thiện các khó khăn về giao tiếp. Thứ tự ưu

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Kharchenko, Yu V., L. Ya Kharchenko, O. V. Antsyferova, and V. V. Pozdniakov. "Features of corn accessions from the collection of Ustymivka experimental station of plant production for antioxidant properties and valuable economic characteristics." Genetičnì resursi roslin (Plant Genetic Resources), no. 30 (2022): 88–97. http://dx.doi.org/10.36814/pgr.2022.30.08.

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Aim – to evaluate corn accessions for antioxidant activity using a test based on the stable DPPH radical and to identify sources of valuable economic characteristics and high antioxidant activity in kernels for heterosis breeding. Results and Discussion. The article covers the results of studying antioxidant activity (AOA) in 178 accessions belonging to seven corn subspecies in 2017-2019. The accessions come from 14 countries, including 120 from Ukraine, and have various pigmentation of kernels. It was found that the antioxidant activity of kernels varied within 22.6-82.7%; the chlorogenic aci

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von Gerhardt, Amber L., Ingrid Vriend, Evert Verhagen, Johannes L. Tol, Gino M. M. J. Kerkhoffs, and Guus Reurink. "Systematic development of an injury prevention programme for judo athletes: the IPPON intervention." BMJ Open Sport & Exercise Medicine 6, no. 1 (2020): e000791. http://dx.doi.org/10.1136/bmjsem-2020-000791.

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ObjectivesTo systematically develop an injury prevention programme in judo and test its feasibility: Injury Prevention and Performance Optimization Netherlands (IPPON) intervention.MethodsWe used the five-step Knowledge Transfer Scheme (KTS) guidelines. In the first two steps, we described the injury problem in judo and showed possibilities to reduce the injury rates. In the third step, the Knowledge Transfer Group (KTG) translated this information into actions in judo practice. Expert meetings and practical sessions were held. In the fourth step, we developed the injury prevention programme a

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Chung, Ho Sub, Yunhyung Choi, Ji Yeon Lim, et al. "Validation of the Korean Version of the Clinical Frailty Scale-Adjusted Korean Triage and Acuity Scale for Older Patients in the Emergency Department." Medicina 60, no. 6 (2024): 955. http://dx.doi.org/10.3390/medicina60060955.

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Background and Objectives: The Clinical Frailty Scale (CFS), used to screen for prehospital frailty in patients aged >65 years, is simple, time-efficient, and has been validated in emergency departments (EDs). In this study, we analyzed whether the Korean Triage and Acuity Scale (KTAS) classification by level in older patients determined to have frailty based on the Korean version of the CFS increases the triage performance of the current KTAS. Materials and Methods: The primary outcome was 30-day in-hospital mortality, and secondary outcomes were hospital and intensive care unit (ICU) admi

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Marbun, Maruhum Bonar H., Riahdo J. Saragih, and Tantika Andina. "Management of COVID-19 in Kidney Transplant Recipients: A Single-Center Case Series." International Journal of Nephrology 2022 (August 18, 2022): 1–7. http://dx.doi.org/10.1155/2022/9636624.

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Background. Kidney transplant recipients (KTRs) were reported to be at higher risk of developing severe coronavirus disease-2019 (COVID-19). Despite being one of the most impacted countries, little is known about KTRs with COVID-19 in Indonesia. This report aims to explore the management strategies and short-term clinical outcomes of KTRs with COVID-19 in an Indonesian transplant center. Methods. We observed KTRs who were admitted following COVID-19 diagnosis. Anamnesis, physical, laboratory, and radiologic examinations were performed. Demographic and transplant histories were recorded, along

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Muhammad Bin Zia and Qurba Kiran. "Rehabilitative Role of Kinesio Taping in Glenohumeral Ligament Injuries: A Narrative Review." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Rehab) (2025): 590–95. https://doi.org/10.71000/yxwqwd53.

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BackgroundGlenohumeral ligament injuries, commonly resulting from trauma or repetitive overhead activity, pose significant challenges in musculoskeletal rehabilitation. With rising interest in conservative, non-invasive management strategies, Kinesio Taping (KT) has gained attention for its proposed benefits in pain reduction, proprioceptive enhancement, and joint stabilization. Despite widespread clinical use, the evidence supporting KT’s efficacy in shoulder ligament rehabilitation remains inconclusive and warrants thorough examination. ObjectiveThis narrative review aims to synthesize curre

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Radić, Josipa, Sanja Lovrić Kojundžić, Andrea Gelemanović, et al. "Serum Adropin Levels and Body Mass Composition in Kidney Transplant Recipients—Are There Sex Differences?" Diagnostics 13, no. 17 (2023): 2768. http://dx.doi.org/10.3390/diagnostics13172768.

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Adropin is a secretory peptide that regulates glucose, lipid, and protein metabolism, which is closely related to obesity, insulin resistance, dyslipidemia, and atherogenesis. The serum adropin level is related to sex and depends upon nutritional preferences. This study aims to determine the association between serum adropin levels and body composition parameters in kidney transplant recipients (KTRs), especially emphasizing sex differences. Our case–control study involved 59 KTRs (28 postmenopausal women and 31 men) who were divided into two groups according to sex, and each group of those KT

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Brunialti, Milena Karina Coló, Giuseppe G. F. Leite, Gabriela Strafolino Eburneo, et al. "Patterns of Circulating Cytokines and Vascular Markers’ Response in the Presence of COVID-19 in Kidney Transplant Recipients Compared with Non-Transplanted Patients." Viruses 15, no. 11 (2023): 2166. http://dx.doi.org/10.3390/v15112166.

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COVID-19’s severity has been associated with a possible imbalance in the cross-regulation of cytokines and vascular mediators. Since the beginning of the pandemic, kidney transplant recipients (KTRs) have been identified as patients of high vulnerability to more severe diseases. Thus, aiming to describe the patterns of cytokines and vascular mediators and to trace patients’ differences according to their KTR status, this prospective study enrolled 67 COVID-19 patients (20 KTRs) and 29 non-COVID-19 controls before vaccination. A panel comprising 17 circulating cytokines and vascular mediators w

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Kim, M., and J. Park. "MP13: Accuracy of Korean triage and acuity scale when pain severity is used as a modifier." CJEM 20, S1 (2018): S44—S45. http://dx.doi.org/10.1017/cem.2018.167.

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Introduction: Accurate triage is important because under-triage may delay critical care for emergent patients and over-triage may inhibit efficient management of emergency department (ED) resources. In Korea, the Korean Triage and Acuity Scale (KTAS) was developed based on the CTAS in 2015. The purpose of this study was to evaluate the accuracy of KTAS in predicting patient’s severity when degree of pain was used as a modifier. Methods: This was a retrospective observational cohort study, conducted in an ED of urban tertiary university hospital with more than 90,000 visits per year. We studied

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Romero, Anais, Charlotte Laurent, Ludivine Lebourg, et al. "Anti SARS-CoV-2 Monoclonal Antibodies in Pre-Exposure or Post-Exposure in No- or Weak Responder to Vaccine Kidney Transplant Recipients: Is One Strategy Better than Another?" Viruses 16, no. 3 (2024): 381. http://dx.doi.org/10.3390/v16030381.

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Background: Kidney transplant recipients (KTRs) are likely to develop severe COVID-19 and are less well-protected by vaccines than immunocompetent subjects. Thus, the use of neutralizing anti–SARS-CoV-2 monoclonal antibodies (mAbs) to confer a passive immunity appears attractive in KTRs. Methods: This retrospective monocentric cohort study was conducted between 1 January 2022 and 30 September 2022. All KTRs with a weak antibody response one month after three doses of mRNA vaccine (anti spike IgG < 264 (BAU/mL)) have received tixagevimab-cilgavimab in pre-exposure (group 1), post-exposure (g

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Schmidt, Bey-Marrie, Sara Cooper, Taryn Young, and Nasreen S. Jessani. "Characteristics of knowledge translation platforms and methods for evaluating them: a scoping review protocol." BMJ Open 12, no. 6 (2022): e061185. http://dx.doi.org/10.1136/bmjopen-2022-061185.

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IntroductionKnowledge translation platforms (KTPs) are intermediary organisations, initiatives or networks whose intent is to bridge the evidence into action divide. Strategies and tools include collaborative knowledge production, capacity building, information exchange and dialogue to facilitate relevant and timely engagement between researchers and decision-makers and other relevant stakeholders. With the wide range of definitions and descriptions of KTPs, there is a need to (1) provide a nuanced understanding of characteristics of KTPs and (2) assess and consolidate research methods used in

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Veronese-Araújo, Alexandre, Débora D. de Lucena, Isabella Aguiar-Brito, et al. "Sex Differences among Overweight/Obese Kidney Transplant Recipients Requiring Oxygen Support Amid the COVID-19 Pandemic." Medicina 59, no. 9 (2023): 1555. http://dx.doi.org/10.3390/medicina59091555.

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Background and Objectives: Overweight/obesity puts individuals at greater risk for COVID-19 progression and mortality. We aimed to evaluate the impact of overweight/obesity on oxygen (O2) requirement outcomes of male and female kidney transplant recipients (KTRs) during the COVID-19 pandemic. Materials and Methods: We conducted a retrospective analysis of a cohort of KTRs diagnosed with COVID-19. Participants were stratified based on BMI categories, and data on the need for O2 therapy outcome were collected and analyzed separately for male and female KTRs. Results: In total, 284 KTRs (97 males

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Bertrand, Dominique, Mouad Hamzaoui, Veronique Lemée, et al. "Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients." Journal of the American Society of Nephrology 32, no. 9 (2021): 2147–52. http://dx.doi.org/10.1681/asn.2021040480.

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BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients with ESKD, and vaccination is hoped to prevent infection.MethodsBetween January 18 and February 24, 2021, 225 kidney transplant recipients (KTRs) and 45 patients on hemodialysis (HDPs) received two injections of mRNA BNT162b2 vaccine. The postvaccinal humoral and cellular response was explored in the first 45 KTRs and ten HDPs.ResultsAfter the second dose, eight HDPs (88.9%) and eight KTRs (17.8%) developed antispike SARS-CoV-2 antibodies (P<0.001). Median titers of

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Halabi, Wissam J., Mehraneh D. Jafari, Vinh Q. Nguyen, et al. "Colorectal Surgery in Kidney Transplant Recipients: A Decade of Trends and Outcomes in the United States." American Surgeon 79, no. 10 (2013): 1026–33. http://dx.doi.org/10.1177/000313481307901015.

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There is paucity of data evaluating the trends and outcomes of colorectal surgery (CRS) in kidney transplant recipients (KTRs). Using the Nationwide Inpatient Sample 2001 to 2010, a retrospective review of CRS performed in KTRs was performed. Trends, demographics, indications, and outcomes were examined for elective and emergent cases and compared with the general population (GP) on multivariate logistic regression. A total of 2616 KTRs underwent CRS, 50 per cent of which were done emergently. KTRs developed colon and rectal cancer at a younger age and had significantly higher incidence of com

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Trivyza, Maria Stella, Charikleia Stergiopoulou, Sotiris Tsakas, et al. "Circulating Immune Complexes and Complement Activation in Sensitized Kidney Transplant Recipients." International Journal of Molecular Sciences 25, no. 20 (2024): 10904. http://dx.doi.org/10.3390/ijms252010904.

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Chronic antibody-mediated rejection in kidney transplantation is a common cause of graft loss in the late post-transplant period. In this process, the role of the classical complement activation pathway is crucial due to the formation of immune complexes between donor-specific antibodies (DSAs) and donor antigens and the attachment of the C1q complement fragment. This study aimed to determine the levels of circulating C1q immunocomplexes (CIC-C1q) and complement activation (CH50), in sensitized kidney transplant recipients (KTRs). In this cross-sectional study we used serum samples from KTRs w

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Kaminski, Hannah, Marta Jarque, Mathieu Halfon, et al. "Different impact of rATG induction on CMV infection risk in D+R– and R+ KTRs." Journal of Infectious Diseases 220, no. 5 (2019): 761–71. http://dx.doi.org/10.1093/infdis/jiz194.

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Abstract Background Rabbit antithymocyte globulin (rATG) induction is associated with profound immunosuppression, leading to a higher risk of cytomegalovirus (CMV) infection compared with anti–interleukin 2 receptor antibody (anti–IL-2RA). However, this risk, depending on the baseline CMV serological recipient/donor status, is still controversial. Methods The CMV DNAemia-free survival between rATG- and anti–IL-2RA–treated patients was analyzed in donor-positive/recipient-negative (D+R−) and recipient-positive (R+) patients in 1 discovery cohort of 559 kidney transplant recipients (KTRs) and 2

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Raval, Amit D., Michael Ganz, Priya Saravanan, Yuexin Tang, and Carlos Santos. "1378. Impact of Cytomegalovirus Prophylaxis on Clinical Outcomes in Kidney Transplantation: A United States Renal Data System-Medicare Linked Database Study." Open Forum Infectious Diseases 8, Supplement_1 (2021): S775. http://dx.doi.org/10.1093/ofid/ofab466.1570.

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Abstract Background Guidelines recommends cytomegalovirus (CMV) prophylaxis by CMV serostatus/risk status, as the currently available antiviral agents may lead to myelosuppressive events in kidney transplant recipients (KTRs). Limited data exist for the United States (US) on the such clinical outcomes with CMV prophylaxis KTRs especially stratified by CMV risk strata. We examined the associations between clinical outcomes and CMV prophylaxis among adult KTRs stratified by CMV risk strata. Methods We employed a retrospective cohort design using the US Renal Data System registry-linked Medicare

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Sato, Tetsuhiko, Emi Ohara, Chikafumi Ozone, et al. "A Possible Advantage of Glucagon-Like Peptide 1 Receptor Agonist in Kidney Transplant Recipients With Type 2 Diabetes." Journal of the Endocrine Society 5, Supplement_1 (2021): A405—A406. http://dx.doi.org/10.1210/jendso/bvab048.826.

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Abstract Diabetic kidney disease (DKD), a devastating complication of diabetes, is one of the leading causes of end stage kidney disease (ESKD). Kidney transplantation provides superior outcomes for ESKD patients with type 2 diabetes, giving opportunities to be free from dialysis, but needs lifetime immunosuppressive medications to avoid graft kidney rejection. Post-transplant hyperglycemia, however, remains to be unsolved, because immunosuppressive agents, including glucocorticoids and calcineurin inhibitors, may result in impaired insulin secretion and sensitivity. Safe and promising anti-di

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Qiu, Shawn, Roham Hadidchi, Aditi Vichare, et al. "SARS-CoV-2 Infection Is Associated with an Accelerated eGFR Decline in Kidney Transplant Recipients up to Four Years Post Infection." Diagnostics 15, no. 9 (2025): 1091. https://doi.org/10.3390/diagnostics15091091.

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Background/Objectives: Although kidney transplant recipients (KTRs) who are immune-compromised have been shown to be at high risk of adverse acute COVID-19 outcomes (i.e., mortality and critical illness), the long-term outcomes of KTRs with a history of SARS-CoV-2 infection are unknown. We aimed to compare long-term outcomes of KTRs with and without exposure to SARS-CoV-2. Methods: This study retrospectively evaluated 1815 KTRs in the Montefiore Health System from 4 January 2001 to 31 January 2024. The final cohorts consisted of KTRs who survived COVID-19 (n = 510) and matched KTRs without COV

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Mucha, Krzysztof, Rafał Staros, Bartosz Foroncewicz, et al. "Comparison of Post-Transplantation Lymphoproliferative Disorder Risk and Prognostic Factors between Kidney and Liver Transplant Recipients." Cancers 14, no. 8 (2022): 1953. http://dx.doi.org/10.3390/cancers14081953.

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Post-transplantation lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation (SOT). Its development risk varies among organ graft recipients. In this study, retrospective data were analyzed to compare PTLD’s risk and prognostic factors between adult kidney and liver transplant recipients (KTRs and LTRs, respectively). Over 15 years, 2598 KTRs and 1378 LTRs were under observation at our center. Sixteen KTRs (0.62%) and twenty-three LTRs (1.67%) were diagnosed with PTLD. PTLD developed earlier in LTRs (p < 0.001), SOT patients > 45 years old (p

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Kwon, Hyuksool, Yu Jin Kim, You Hwan Jo, et al. "The Korean Triage and Acuity Scale: associations with admission, disposition, mortality and length of stay in the emergency department." International Journal for Quality in Health Care 31, no. 6 (2018): 449–55. http://dx.doi.org/10.1093/intqhc/mzy184.

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Abstract Objective The Korean Triage and Acuity Scale (KTAS) was implemented in our emergency department (ED) in May 2016 and is fully integrated into the electronic medical record (EMR) system. Our objective was to determine whether the KTAS is associated with changes in admissions to the hospital, admission disposition, inpatient mortality and length of stay (LOS). Design Quasi-experimental, uncontrolled before-and-after study. Setting The urban tertiary teaching hospital with 1100 beds and receives approximately annual 90 000 ED visits. Participants 122 370 patients who visited the ED durin

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Battaglia, Yuri, Antonio Bellasi, Pasquale Esposito, et al. "The Impact of Cholecaciferol Supplementation on Bone Mineral Density in Long-Term Kidney Transplant Recipients." Biomolecules 13, no. 4 (2023): 629. http://dx.doi.org/10.3390/biom13040629.

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Although reduced bone mineral density (BMD) is associated with a higher risk of fractures, morbidity, and mortality in kidney transplant patients (KTRs), there is no consensus on optimal treatment for the alterations of BMD in this population. This study aims at assessing the effect of cholecalciferol supplementation on BMD over a follow-up period of 2 years in a cohort of long-term KTRs. Patients with age ≥ 18 years were included and divided into two subgroups based on treatment with bisphosphonate and/or calcimimetics and/or active vitamin D sterols (KTRs-treated) or never treated with the a

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Patti, Alessandro, Daniel Neunhaeuserer, Sara Ortolan, et al. "A clinical evaluation of VO2 kinetics in kidney transplant recipients." European Journal of Applied Physiology 121, no. 7 (2021): 2005–13. http://dx.doi.org/10.1007/s00421-021-04672-x.

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Abstract Purpose Aerobic exercise capacity is reduced in patients with chronic kidney disease, partly due to alterations at the muscular and microvascular level. This study evaluated oxygen uptake (VO2) kinetics as indicator of muscular oxidative metabolism in a population of Kidney Transplant Recipients (KTRs). Methods Two groups of KTRs enrolled 3 (n = 21) and 12 months (n = 14) after transplantation and a control group of healthy young adults (n = 16) underwent cardiopulmonary exercise testing on cycle-ergometer. The protocol consisted in two subsequent constant, moderate-load exercise phas

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Juarez, Ignacio, Isabel Pérez-Flores, Arianne S. Aiffil Meneses, et al. "Immunosuppressive Therapy Modifies Anti-Spike IgG Subclasses Distribution After Four Doses of mRNA Vaccination in a Cohort of Kidney Transplant Recipients." Vaccines 13, no. 2 (2025): 123. https://doi.org/10.3390/vaccines13020123.

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Background: IgG4 is the least immunogenic subclass of IgG. Immunization with mRNA vaccines against SARS-CoV-2, unlike other vaccines, induces an increase in IgG4 against the spike protein in healthy populations. This study investigated whether immunosuppressive therapy affects the immune response, focusing on IgG subclass changes, to four doses of mRNA vaccine in kidney transplant recipients (KTRs). Methods: This study includes 146 KTRs and 23 dialysis patients (DPs) who received three mRNA-1273 vaccine doses and a BNT162b2 booster. We evaluated anti-spike IgG titers and subclasses, T-CD4+ and

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N. Rahmatunisa, L. Cyrilla, and I. Komala. "Fresh Milk Supply Chain Analysis in Kelompok Ternak Mandiri Sejahtera using Food Supply Chain Network Approach." Jurnal Ilmu Produksi dan Teknologi Hasil Peternakan 12, no. 3 (2024): 151–57. http://dx.doi.org/10.29244/jipthp.12.3.151-157.

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Supply chain management plays a role in ensuring the availability of raw materials from suppliers to the final product reaching consumers. Kelompok Ternak Mandiri Sejahtera (KTMS) is a cooperative that acts as a link between farmers and dairy processing consumers. However, research on theapplication of the supply chain concept at KTMS has not yet been explored. One commonly used approach to analyze supply chain conditions is the Food Supply Chain Network (FSCN). Therefore, the aim of this study is to analyze the fresh milk supply chain conditions at KTMS using the FSCNapproach to comprehensive

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Wynn, Martin, and Peter Jones. "Knowledge Transfer Partnerships and the entrepreneurial university." Industry and Higher Education 31, no. 4 (2017): 267–78. http://dx.doi.org/10.1177/0950422217705442.

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This article outlines one way in which less research-intensive universities can contribute to entrepreneurship by examining the achievements of several Knowledge Transfer Partnerships (KTPs) in the University of Gloucestershire. The article adopts a qualitative case study approach: four case studies of KTPs at, respectively, Beacons Business Interiors, Dowty Propellers, Energist UK and Muddy Boots Software (all of which have operating bases within 40 miles of the University) are researched and analysed. The findings reveal that these four KTPs delivered various benefits for the companies, the

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Coleman, D. L., T. S. Kupper, P. M. Flood, C. C. Fultz, and M. C. Horowitz. "Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1." Journal of Immunology 138, no. 10 (1987): 3314–18. http://dx.doi.org/10.4049/jimmunol.138.10.3314.

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Abstract Epidermal epithelial cells (keratinocytes) produce and secrete a variety of immunologically active cytokines. We have previously reported that both transformed (PAM 212) and normal murine keratinocytes produce a soluble factor which induces proliferation of the T cell line, HT-2. In the present study we sought to compare keratinocyte-derived T cell growth factor (KTGF) with other T cell growth factors, characterize its physicochemical properties, and substantially purify KTGF from PAM 212 conditioned medium. KTGF from PAM 212 conditioned medium was not inhibited by antibodies which bl

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Costa Silva, Alberto, Teresa Pina-Vaz, Afonso Morgado, Carlos Martins-Silva, Tiago Antunes-Lopes, and João Alturas Silva. "The Role of the Urobiome in Kidney Transplantation: A Systematic Review." Transplantation Direct 10, no. 6 (2024): e1643. http://dx.doi.org/10.1097/txd.0000000000001643.

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Background. The urinary microbiome, also known as the urobiome, was traditionally considered sterile. However, emerging evidence suggests its presence in the urinary tract. Urobiome dysbiosis has been associated with various urologic conditions, making it a topic of interest also in kidney transplantation. This systematic review examines the evidence of urobiome changes in kidney transplant recipients (KTRs). Methods. Systematic literature searches in the PubMed and SCOPUS databases. Results. Of the 770 articles identified, 8 met the inclusion criteria. The urobiome showed reduced diversity in

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Li, Yangling, Ying Su, Yongjuan Liang, et al. "Quality Evaluation of Kidney Tea Granules From Different Origins Based on TLC, HPLC Fingerprinting, and Quantitative Analysis Combined With Chemical Pattern Recognition." Phytochemical Analysis, October 23, 2024. http://dx.doi.org/10.1002/pca.3458.

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ABSTRACTIntroductionKidney tea is an essential herbal medicine. It is widely used to treat conditions such as urinary stones, gallstones, and rheumatoid arthritis. There is currently no standardized or widely accepted research strategy for evaluating the quality of kidney tea granules (KTGs) after granulation.ObjectivesIn this study, we aim to establish a comprehensive strategy for evaluating the quality of KTGs produced from different sources of kidney tea.MethodsA TLC combined with HPLC method was established to identify the chemical components in KTGs, and HPLC method was used to determine

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Puteaux, Chloe, Isabelle Toubia, Lina Truong, et al. "Light‐Induced Unlocking Reactivity of Fragments for Fast Target‐Guided Synthesis of Carbonic Anhydrase Inhibitors." Angewandte Chemie International Edition, July 14, 2024. http://dx.doi.org/10.1002/anie.202407888.

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We showcase the successful combination of photochemistry and kinetic target‐guided synthesis (KTGS) for rapidly pinpointing enzyme inhibitors. KTGS is a fragment‐based drug discovery (FBDD) methodology in which the biological target (BT) orchestrates the construction of its own ligand from fragments featuring complementary reactive functionalities. Notably, fragments interacting with the protein binding sites leverage their spatial proximity, facilitating a preferential reaction. Consequently, the resulting bivalent ligand exhibits heightened affinity. Within the realm of KTGS strategies, in s

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Puteaux, Chloe, Isabelle Toubia, Lina Truong, et al. "Light‐Induced Unlocking Reactivity of Fragments for Fast Target‐Guided Synthesis of Carbonic Anhydrase Inhibitors." Angewandte Chemie, July 14, 2024. http://dx.doi.org/10.1002/ange.202407888.

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We showcase the successful combination of photochemistry and kinetic target‐guided synthesis (KTGS) for rapidly pinpointing enzyme inhibitors. KTGS is a fragment‐based drug discovery (FBDD) methodology in which the biological target (BT) orchestrates the construction of its own ligand from fragments featuring complementary reactive functionalities. Notably, fragments interacting with the protein binding sites leverage their spatial proximity, facilitating a preferential reaction. Consequently, the resulting bivalent ligand exhibits heightened affinity. Within the realm of KTGS strategies, in s

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Parvatkar, Prakash T., and Roman Manetsch. "The emergence of sulfo-click amidation in kinetic target-guided synthesis." Medicinal Chemistry Research, May 18, 2024. http://dx.doi.org/10.1007/s00044-024-03236-w.

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AbstractSulfo-click is a chemoselective and biocompatible reaction between thioacids and sulfonyl azides that forms highly versatile N-acylsulfonamides, interesting bioisosteres of carboxylic acids. This reaction is useful for chemists and biologists and has many applications in medicinal chemistry, drug discovery, bioconjugation chemistry, and chemical biology. Sulfo-click amidations have been extensively used in kinetic target-guided synthesis (KTGS) to identify modulators of protein-protein interactions (PPIs). Different variants of KTGS screening, such as binary and multi-fragments, as wel

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Huang, Lili, Prakash Parvatkar, Alicia Wagner, Sameer Kulkarni, and Roman Manetsch. "Chemoselective seleno-click amidation in kinetic target-guided synthesis." Chemical Communications, 2024. http://dx.doi.org/10.1039/d4cc04491f.

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Capitalizing on our previous kinetic target-guided synthesis (KTGS) involving the sulfo-click reaction to form N-acylsulfonamide-linked inhibitors in the presence of the protein-protein interaction target Mcl-1, we herein report a seleno-click...

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Buxeda, Anna, Gonzalo Velis, Carlos Arias-Cabrales, et al. "Kidney transplantation outcomes from elderly donors after circulatory death: a comparison with elderly brain-dead donors." Clinical Kidney Journal, September 10, 2020. http://dx.doi.org/10.1093/ckj/sfaa114.

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Abstract Background The use of kidneys from elderly controlled donation after circulatory death (cDCD) donors has increased significantly in recent years. Concerns about outcomes achieved with these elderly cDCD kidneys have arisen. We aimed to compare outcomes from elderly cDCD kidney transplant recipients (KTrs) and elderly donation after brain death donors (DBDs) in KTrs. Methods We conducted a single-centre retrospective study including 87 cDCD-KTrs (46 from donors ≥65 years of age and 41 from &lt;65 years) and 126 DBD-KTrs from donors ≥65 years of age from 2013 through 2017). Young cD

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Choudhary, Devprakash, Rajesh Vijayvergiya, Kamal Kishore, et al. "Vascular Reconstruction of Multiple Renal Arteries—A Risk Factor for Transplant Renal Artery Stenosis: Insight From a Matched Case-Control Study." Transplant International 37 (November 7, 2024). http://dx.doi.org/10.3389/ti.2024.13298.

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Transplant Renal Artery Stenosis (TRAS) is the leading vascular complication following kidney transplantation (KT), causing premature allograft loss and increased post-KT mortality. While risk factors for TRAS, such as prolonged cold ischemia time and delayed graft function, are well-documented in deceased donor-KT, the risk factors remain less clearly defined in living donor-KT. This matched case-control study, conducted at a leading national transplant center predominantly performing living donor-KT, evaluated risk factors and long-term outcomes of clinical TRAS (cTRAS). cTRAS cases diagnose

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Weidmann, Lukas, Nicolas Schmid, Kai Castrezana Lopez, Thomas Mueller, and Thomas Schachtner. "#3148 PROTEINURIA AND TYPE OF KIDNEY ALLOGRAFT INJURY IDENTIFY KIDNEY TRANSPLANT RECIPIENTS BENEFITING MOST FROM BELATACEPT CONVERSION." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_3148.

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Abstract Background and Aims Belatacept conversion is associated with an improvement in kidney allograft function. Yet, not all kidney transplant recipients (KTRs) seem to benefit equally from this alteration of maintenance immunosuppression. Both type (alloimmune vs. non-alloimmune) and severity (assessed by proteinuria) of kidney allograft injury may impact the functional response to a belatacept conversion. Method We studied 37 KTRs from belatacept conversion to 1-year post-conversion. KTRs were categorized concerning pre-conversion proteinuria: 21 KTRs with low proteinuria (&lt;500 mg/

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Näf, Bettina, Thomas Müller, Rudolf Peter Wuthrich, and Thomas Schachtner. "P1639DEVELOPMENT OF SELF-LIMITED LOW-LEVEL BK VIREMIA/VIRURIA SUGGESTS IDEAL IMMUNOSUPPRESSION TO SUPPRESS T-CELL AND ANTIBODY-MEDIATED REJECTION AND PRESERVE KIDNEY ALLOGRAFT FUNCTION." Nephrology Dialysis Transplantation 35, Supplement_3 (2020). http://dx.doi.org/10.1093/ndt/gfaa142.p1639.

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Abstract Background and Aims Polyomavirus BK (BKV) viremia has been suggested as a surrogate marker of overimmunosuppression. Due to recent advances in monitoring strategies and pre-emptive therapy, progression to BKV-associated nephropathy (BKVN) has been reduced. Reduction of maintenance immunosuppression during BKVN, however, has been associated with both T-cell mediated rejection (TCMR), antibody-mediated rejection (ABMR), and inferior kidney allograft outcomes. Although the administration of intravenous immunoglobulins (IVIG) failed to treat BKVN, IVIG may have properties to reduce allose

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Noshadi, Nasrin, Ramin Yaghobi, Afsoon Afshari, Mohsen Forouzanfar, and Saeede Soleimanian. "Polyomavirus BK-Specific CD4+ T Cells Response to VP1 Stimulation in Kidney Transplant Recipients." Iranian Journal of Allergy, Asthma and Immunology, June 5, 2024. http://dx.doi.org/10.18502/ijaai.v23i3.15637.

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Reactivation of Polyomavirus BK (BKPyV) is related to reduction of T cells response in kidney transplant recipients (KTRs). Here, we examined the differentiation of CD4+ T cells subsets in response to BKPyV KTRs, using the BKPyV VP1 (viral capsid protein 1) as a stimulator. We categorized our samples into three distinct groups: 1. Reactive BKPyV (BKPyV+), 2. non-reactive (BKPyV-) KTRs and 3. Healthy controls. BKPyV- KTRs and healthy controls stimulated with VP1 and BKPyV+ unstimulated with VP1. The human CD4+ T cells was stimulation with VP1-Ag. The proportion of CD4+ T lymphocytes and their v

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Halaji, Mehrdad, Shahrzad Shahidi, Behrooz Ataei, Abdolamir Atapour, Awat Feizi, and Seyed Asghar Havaei. "Molecular epidemiology of blaCTX-M gene-producing uropathogenic Escherichia coli among Iranian kidney transplant patients: clonal dissemination of CC131 and CC10." Annals of Clinical Microbiology and Antimicrobials 20, no. 1 (2021). http://dx.doi.org/10.1186/s12941-021-00470-7.

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Abstract Background This study aimed to investigate the phylogenetic characterization and virulence traits of uropathogenic Escherichia coli (UPEC) isolated from kidney transplant patients (KTPs) as well as non-KTPs and analyze the clonal distribution of Extended spectrum β-lactamases (ESBLs)-producing UPEC containing blaCTX-M gene. Methods To this end, we determined virulence marker and the phylogenetic characterization of UPEC in non-KTPs (n = 65) and KTPs (n = 46). The non-KTPs were considered the control group of the study. Also, according to the Achtman scheme, we performed multilocus seq

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Larsen, Helle Kiellberg, Susanne K. Kjaer, Merete Haedersdal, et al. "Anal human papillomavirus infection in kidney transplant recipients compared with immunocompetent controls." Clinical Infectious Diseases, April 19, 2022. http://dx.doi.org/10.1093/cid/ciac285.

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Abstract Background Kidney transplant recipients (KTRs) have increased risk of human papillomavirus (HPV)-related anogenital (pre-)cancers, including anal high-grade intraepithelial lesions (HSIL) and cancer. Previous studies on anal high-risk HPV among KTRs are sparse. Methods In a cross-sectional study, we included 247 KTRs and 248 controls from a dermatology department and five nephrology departments in Denmark during 2016–2017. All participants underwent an anal cytobrush sample which was tested for HPV-DNA. Participants completed a questionnaire on lifestyle and sexual habits. We used log

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Karaba, Andrew H., William R. Morgenlander, Trevor S. Johnston, et al. "Epitope Mapping of SARS-CoV-2 Spike Antibodies in Vaccinated Kidney Transplant Recipients Reveals Poor Spike Coverage Compared to Healthy Controls." Journal of Infectious Diseases, November 29, 2023. http://dx.doi.org/10.1093/infdis/jiad534.

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Abstract Kidney transplant recipients (KTRs) develop decreased antibody titers to SARS-CoV-2 vaccination compared to healthy controls (HCs), but whether KTRs generate antibodies against key epitopes associated with neutralization is unknown. Plasma from 78 KTRs from a clinical trial of third doses of SARS-CoV-2 vaccines and 12 HCs underwent phage display immunoprecipitation and sequencing (PhIP-Seq) to map antibody responses against SARS-CoV-2. KTRs had lower antibody reactivity to SARS-CoV-2 than HCs, but KTRs and HCs recognized similar epitopes associated with neutralization. Thus, epitope g

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