Relevant bibliographies by topics / Kukoamine a

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Academic literature on the topic 'Kukoamine a'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Kukoamine a"

1

Zheng, Xinchuan, Ning Wang, Yongjun Yang, Yingchun Chen, Xin Liu, and Jiang Zheng. "Insight into the inhibition mechanism of kukoamine B against CpG DNA via binding and molecular docking analysis." RSC Advances 6, no. 89 (2016): 85756–62. http://dx.doi.org/10.1039/c6ra11646a.

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2

Hadjipavlou-Litina, Dimitra, Thomas Garnelis, Constantinos M. Athanassopoulos, and Dionissios Papaioannou. "Kukoamine A analogs with lipoxygenase inhibitory activity." Journal of Enzyme Inhibition and Medicinal Chemistry 24, no. 5 (2009): 1188–93. http://dx.doi.org/10.1080/14756360902779193.

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3

Ponasik, J. A., C. Strickland, C. Faerman, S. Savvides, P. A. Karplus, and B. Ganem. "Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase." Biochemical Journal 311, no. 2 (1995): 371–75. http://dx.doi.org/10.1042/bj3110371.

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The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting parasitic trypanosomatids against oxidative stress and is a target for drug design. Here we show that a naturally occurring spermine derivative, the antihypertensive agent kukoamine A [N1N12-bis(dihydrocaffeoyl)-spermine] inhibits TR as a mixed inhibitor (Ki = 1.8 microM, Kii = 13 microM). Kukoamine shows no significant inhibition of human glutathione reductase (Ki > 10 mM) and thus provides a novel selective drug lead. The correspon
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4

Dong, Kai. "The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate." Synlett 29, no. 20 (2018): 2669–72. http://dx.doi.org/10.1055/s-0037-1610326.

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The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.
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5

Funayama, Shinji, Gui-Rong Zhang, and Shigeo Nozoe. "Kukoamine B, a spermine alkaloid from Lycium chinense." Phytochemistry 38, no. 6 (1995): 1529–31. http://dx.doi.org/10.1016/0031-9422(94)00826-f.

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6

Yang, Dong, Xinchuan Zheng, Ning Wang, et al. "Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes." Oncotarget 7, no. 36 (2016): 57498–513. http://dx.doi.org/10.18632/oncotarget.11292.

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7

Karigiannis, George, Petros Mamos, George Balayiannis, Ioannis Katsoulis, and Dionissios Papaioannou. "Simple fragment syntheses of all four isomers of the spermine alkaloid kukoamine." Tetrahedron Letters 39, no. 28 (1998): 5117–20. http://dx.doi.org/10.1016/s0040-4039(98)00940-x.

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8

Li, Guangyun, Fang Zhou, Ying Chen, Weiguo Zhang, and Ning Wang. "Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c." Biomedicine & Pharmacotherapy 89 (May 2017): 536–43. http://dx.doi.org/10.1016/j.biopha.2017.02.024.

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9

Wang, Lin, Peipei Wang, Dandan Wang, Mengqing Tao, Wenke Xu, and Opeyemi Joshua Olatunji. "Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller." Natural Product Communications 15, no. 3 (2020): 1934578X2091208. http://dx.doi.org/10.1177/1934578x20912088.

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Kukoamine A (Kuk A) is a naturally occurring bioactive spermine alkaloid found in the root bark of Lycium chinense, and it exerts various therapeutic effects including antioxidant, neuroprotective, anti-inflammatory, and antidiabetic effects. This study evaluated the anti-inflammatory properties of Kuk A against lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells and carrageenan-induced paw edema in rats. Pretreatment of cells with Kuk A significantly inhibited the production of reactive oxygen species, nitric oxide, prostaglandin E2, cyclooxygenase-2 activity, tumor ne
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10

Parr, Adrian J., Fred A. Mellon, Ian J. Colquhoun, and Howard V. Davies. "Dihydrocaffeoyl Polyamines (Kukoamine and Allies) in Potato (Solanum tuberosum) Tubers Detected during Metabolite Profiling." Journal of Agricultural and Food Chemistry 53, no. 13 (2005): 5461–66. http://dx.doi.org/10.1021/jf050298i.

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Dissertations / Theses on the topic "Kukoamine a"

1

Léon, Patrick. "Alkylation d'amines par les sels de sulfonium, reaction de type gabriel et synthese de polyamines." Paris 6, 1987. http://www.theses.fr/1987PA066488.

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