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Journal articles on the topic 'Kukoamine a'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Zheng, Xinchuan, Ning Wang, Yongjun Yang, Yingchun Chen, Xin Liu, and Jiang Zheng. "Insight into the inhibition mechanism of kukoamine B against CpG DNA via binding and molecular docking analysis." RSC Advances 6, no. 89 (2016): 85756–62. http://dx.doi.org/10.1039/c6ra11646a.

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2

Hadjipavlou-Litina, Dimitra, Thomas Garnelis, Constantinos M. Athanassopoulos, and Dionissios Papaioannou. "Kukoamine A analogs with lipoxygenase inhibitory activity." Journal of Enzyme Inhibition and Medicinal Chemistry 24, no. 5 (2009): 1188–93. http://dx.doi.org/10.1080/14756360902779193.

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3

Ponasik, J. A., C. Strickland, C. Faerman, S. Savvides, P. A. Karplus, and B. Ganem. "Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase." Biochemical Journal 311, no. 2 (1995): 371–75. http://dx.doi.org/10.1042/bj3110371.

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The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting parasitic trypanosomatids against oxidative stress and is a target for drug design. Here we show that a naturally occurring spermine derivative, the antihypertensive agent kukoamine A [N1N12-bis(dihydrocaffeoyl)-spermine] inhibits TR as a mixed inhibitor (Ki = 1.8 microM, Kii = 13 microM). Kukoamine shows no significant inhibition of human glutathione reductase (Ki > 10 mM) and thus provides a novel selective drug lead. The correspon

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4

Dong, Kai. "The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate." Synlett 29, no. 20 (2018): 2669–72. http://dx.doi.org/10.1055/s-0037-1610326.

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The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.

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5

Funayama, Shinji, Gui-Rong Zhang, and Shigeo Nozoe. "Kukoamine B, a spermine alkaloid from Lycium chinense." Phytochemistry 38, no. 6 (1995): 1529–31. http://dx.doi.org/10.1016/0031-9422(94)00826-f.

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6

Yang, Dong, Xinchuan Zheng, Ning Wang, et al. "Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes." Oncotarget 7, no. 36 (2016): 57498–513. http://dx.doi.org/10.18632/oncotarget.11292.

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7

Karigiannis, George, Petros Mamos, George Balayiannis, Ioannis Katsoulis, and Dionissios Papaioannou. "Simple fragment syntheses of all four isomers of the spermine alkaloid kukoamine." Tetrahedron Letters 39, no. 28 (1998): 5117–20. http://dx.doi.org/10.1016/s0040-4039(98)00940-x.

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8

Li, Guangyun, Fang Zhou, Ying Chen, Weiguo Zhang, and Ning Wang. "Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c." Biomedicine & Pharmacotherapy 89 (May 2017): 536–43. http://dx.doi.org/10.1016/j.biopha.2017.02.024.

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9

Wang, Lin, Peipei Wang, Dandan Wang, Mengqing Tao, Wenke Xu, and Opeyemi Joshua Olatunji. "Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller." Natural Product Communications 15, no. 3 (2020): 1934578X2091208. http://dx.doi.org/10.1177/1934578x20912088.

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Kukoamine A (Kuk A) is a naturally occurring bioactive spermine alkaloid found in the root bark of Lycium chinense, and it exerts various therapeutic effects including antioxidant, neuroprotective, anti-inflammatory, and antidiabetic effects. This study evaluated the anti-inflammatory properties of Kuk A against lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells and carrageenan-induced paw edema in rats. Pretreatment of cells with Kuk A significantly inhibited the production of reactive oxygen species, nitric oxide, prostaglandin E2, cyclooxygenase-2 activity, tumor ne

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10

Parr, Adrian J., Fred A. Mellon, Ian J. Colquhoun, and Howard V. Davies. "Dihydrocaffeoyl Polyamines (Kukoamine and Allies) in Potato (Solanum tuberosum) Tubers Detected during Metabolite Profiling." Journal of Agricultural and Food Chemistry 53, no. 13 (2005): 5461–66. http://dx.doi.org/10.1021/jf050298i.

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11

KARIGIANNIS, G., P. MAMOS, G. BALAYIANNIS, I. KATSOULIS, and D. PAPAIOANNOU. "ChemInform Abstract: Simple Fragment Syntheses of All Four Isomers of the Spermine Alkaloid Kukoamine." ChemInform 29, no. 40 (2010): no. http://dx.doi.org/10.1002/chin.199840252.

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12

Hu, Xiao-Long, Ling-Yue Gao, Yi-Xuan Niu, et al. "Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-d-aspartate receptors." Biochimica et Biophysica Acta (BBA) - General Subjects 1850, no. 2 (2015): 287–98. http://dx.doi.org/10.1016/j.bbagen.2014.11.006.

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13

Hu, Xiao-Long, Li-Ping Guo, Qi Song, et al. "Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro." Neurochemistry International 87 (August 2015): 66–76. http://dx.doi.org/10.1016/j.neuint.2015.06.001.

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14

Liu, Jia, Xiaowen Jiang, Qiao Zhang, et al. "Neuroprotective effects of Kukoamine A against cerebral ischemia via antioxidant and inactivation of apoptosis pathway." Neurochemistry International 107 (July 2017): 191–97. http://dx.doi.org/10.1016/j.neuint.2016.12.024.

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15

Vassis, Stratos, George Karigiannis, George Balayiannis, et al. "Simple syntheses of N-alkylated spermidine fragments and analogues of the spermine alkaloid kukoamine A." Tetrahedron Letters 42, no. 8 (2001): 1579–82. http://dx.doi.org/10.1016/s0040-4039(00)02308-x.

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16

Li, Yuan-Yuan, Rui Di, Wing-Leung Hsu, Ye-Qing Huang, Hongyan Sun, and Hon-Yeung Cheung. "Sensitivity improvement of kukoamine determination by complexation with dihydrogen phosphate anions in capillary zone electrophoresis." ELECTROPHORESIS 36, no. 15 (2015): 1801–7. http://dx.doi.org/10.1002/elps.201500030.

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17

Piletska, Elena V., Rosemary Burns, Leon A. Terry, and Sergey A. Piletsky. "Application of a Molecularly Imprinted Polymer for the Extraction of Kukoamine A from Potato Peels." Journal of Agricultural and Food Chemistry 60, no. 1 (2011): 95–99. http://dx.doi.org/10.1021/jf203669b.

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18

Hu, XiaoLong, Qi Song, Xin Li, et al. "Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement." Neuropharmacology 117 (May 2017): 352–63. http://dx.doi.org/10.1016/j.neuropharm.2017.02.022.

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19

Garnelis, Thomas, Constantinos M. Athanassopoulos, Dionissios Papaioannou, Ian M. Eggleston, and Alan H. Fairlamb. "Very Short and Efficient Syntheses of the Spermine Alkaloid Kukoamine A and Analogs Using Isolable Succinimidyl Cinnamates." Chemistry Letters 34, no. 2 (2005): 264–65. http://dx.doi.org/10.1246/cl.2005.264.

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20

Hu, Xiao-Long, Yi-Xuan Niu, Qiao Zhang, et al. "Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells." Environmental Toxicology and Pharmacology 40, no. 1 (2015): 230–40. http://dx.doi.org/10.1016/j.etap.2015.06.017.

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21

Park, Eunkuk, Jeonghyun Kim, Mun-Chang Kim, et al. "Anti-Osteoporotic Effects of Kukoamine B Isolated from Lycii Radicis Cortex Extract on Osteoblast and Osteoclast Cells and Ovariectomized Osteoporosis Model Mice." International Journal of Molecular Sciences 20, no. 11 (2019): 2784. http://dx.doi.org/10.3390/ijms20112784.

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Osteoporosis is an abnormal bone remodeling condition characterized by decreased bone density, which leads to high risks of fracture. Previous study has demonstrated that Lycii Radicis Cortex (LRC) extract inhibits bone loss in ovariectomized (OVX) mice by enhancing osteoblast differentiation. A bioactive compound, kukoamine B (KB), was identified from fractionation of an LRC extract as a candidate component responsible for an anti-osteoporotic effect. This study investigated the anti-osteoporotic effects of KB using in vitro and in vivo osteoporosis models. KB treatment significantly increase

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22

Moriwake, Toshio, Seiki Saito, Hideaki Tamai, Hitoshi Mitsuda, and Masami Inaba. "Total Synthesis of Kukoamine A Using 2-Methyl-5,6-dihydro-4H-1,3-oxazine as a Carboxamide Building Block." HETEROCYCLES 23, no. 2 (1985): 277. http://dx.doi.org/10.3987/r-1985-02-0277.

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23

Liu, Xin, Xinchuan Zheng, Ning Wang, et al. "Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment." British Journal of Pharmacology 162, no. 6 (2011): 1274–90. http://dx.doi.org/10.1111/j.1476-5381.2010.01114.x.

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24

Zhao, Qian, Lili Li, Zhenlei Wang, et al. "Ultra performance liquid chromatography tandem mass spectrometry assay for determination of kukoamine B in human blood and urine." Journal of Chromatography B 1031 (September 2016): 8–14. http://dx.doi.org/10.1016/j.jchromb.2016.07.025.

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25

Zhao, Quan, Linhai Li, Yu Zhu, et al. "Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats." Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Volume 13 (May 2020): 1843–53. http://dx.doi.org/10.2147/dmso.s247844.

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26

Zhang, Yaqiong, Zhihua Cheng, Changli Wang, Hongda Ma, Weihong Meng, and Qingchun Zhao. "Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis." Neurochemical Research 41, no. 10 (2016): 2549–58. http://dx.doi.org/10.1007/s11064-016-1967-0.

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27

Li, Yuping, Shaohua Zeng, Feng Li, et al. "Variation of Kukoamine A (KuA) and B (KuB) contents and related meteorological factors for Cortex Lycii radicis of different areas." Biochemical Systematics and Ecology 88 (February 2020): 103985. http://dx.doi.org/10.1016/j.bse.2019.103985.

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28

Zhang, Yaqiong, Lingyue Gao, Zhihua Cheng та ін. "Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1". Neurotoxicity Research 31, № 2 (2016): 259–68. http://dx.doi.org/10.1007/s12640-016-9679-4.

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29

Li, Yuan-Yuan, Shengquan Hu, Ye-Qing Huang, Yifan Han та Hon-Yeung Cheung. "Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex". Journal of Functional Foods 17 (серпень 2015): 709–21. http://dx.doi.org/10.1016/j.jff.2015.06.029.

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30

Liu, Xin, Xinchuan Zheng, Yupeng Long, et al. "Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii." International Immunopharmacology 11, no. 1 (2011): 110–20. http://dx.doi.org/10.1016/j.intimp.2010.10.015.

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31

Xiao, Xiao, Wei Ren, Nan Zhang, et al. "Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum." Molecules 24, no. 8 (2019): 1585. http://dx.doi.org/10.3390/molecules24081585.

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The fruits, leaves and root barks of L. barbarum plant are widely used as functional foods and as ingredients in traditional Chinese prescriptions and patent medicines. They are considered to have different pharmacological activities and health benefits because of their diverse constituents. Here, the chemical constituents of the extracts from fruits, leaves and root barks of L. barbarum were compared by ultra-high performance liquid chromatography coupled with high resolution mass spectrometry (UPLC-HR-MS). A total of 131 compounds were identified and seven of them were quantified. Among them

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32

Li, Yuan-Yuan, Haixing Wang, Chunyan Zhao, Ye-Qing Huang, Xiaowei Tang, and Hon-Yeung Cheung. "Identification and Characterization of Kukoamine Metabolites by Multiple Ion Monitoring Triggered Enhanced Product Ion Scan Method with a Triple-Quadruple Linear Ion Trap Mass Spectrometer." Journal of Agricultural and Food Chemistry 63, no. 50 (2015): 10785–90. http://dx.doi.org/10.1021/acs.jafc.5b04321.

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33

Wang, Zhenlei, Qian Zhao, Lili Li, et al. "Development and validation of a rapid and sensitive UPLC–MS/MS method for quantification of kukoamine B in human plasma: Application to a clinical pharmacokinetic study." Journal of Pharmaceutical and Biomedical Analysis 132 (January 2017): 1–6. http://dx.doi.org/10.1016/j.jpba.2016.09.032.

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34

QIN, WEI-TING, XU WANG, WEI-CHANG SHEN, and BING-WEI SUN. "A novel role of kukoamine B: Inhibition of the inflammatory response in the livers of lipopolysaccharide-induced septic mice via its unique property of combining with lipopolysaccharide." Experimental and Therapeutic Medicine 9, no. 3 (2015): 725–32. http://dx.doi.org/10.3892/etm.2015.2188.

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35

Yang, Yue, Lingyue Gao, Yixuan Niu та ін. "Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons". Neurochemical Research 45, № 11 (2020): 2703–11. http://dx.doi.org/10.1007/s11064-020-03114-y.

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36

Li, Yuan-Yuan, Rui Di, Joewel T. Baibado, et al. "Identification of kukoamines as the novel markers for quality assessment of Lycii Cortex." Food Research International 55 (January 2014): 373–80. http://dx.doi.org/10.1016/j.foodres.2013.11.008.

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37

Li, Xican, Jian Lin, Ban Chen, Hong Xie, and Dongfeng Chen. "Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect." Molecules 23, no. 4 (2018): 973. http://dx.doi.org/10.3390/molecules23040973.

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38

Jiang, Gandan, Mio Takase, Yukine Aihara, and Hideyuki Shigemori. "Inhibitory activities of kukoamines A and B from Lycii Cortex on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes." Journal of Natural Medicines 74, no. 1 (2019): 247–51. http://dx.doi.org/10.1007/s11418-019-01337-0.

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39

Wang, Huanhuan, Xiaoyun Hu, Teng Wang, et al. "Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients." Frontiers in Pharmacology 12 (April 19, 2021). http://dx.doi.org/10.3389/fphar.2021.645130.

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Aim: Kukoamine B, a small molecule compound, is being developed for the treatment of sepsis in a Phase II clinical trial. The objective of this study was to optimize dosing selection for a Phase IIb clinical trial using an exposure-response model.Methods: Data of 34 sepsis patients from a Phase IIa clinical trial were used in the model: 10 sepsis patients from the placebo group and a total of 24 sepsis patients from the 0.06 mg/kg, 0.12 mg/kg, and 0.24 mg/kg drug groups. Exposure-response relationship was constructed to model the impact of the standard care therapy and area under curve (AUC) o

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40

Li, Yuan-Yuan, Delisha A. Stewart, Xiao-Min Ye, et al. "A Metabolomics Approach to Investigate Kukoamine B—A Potent Natural Product With Anti-diabetic Properties." Frontiers in Pharmacology 9 (January 22, 2019). http://dx.doi.org/10.3389/fphar.2018.01575.

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41

Wang, Qiaoping, Haiyan Li, Zhen Sun, et al. "Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation." Scientific Reports 6, no. 1 (2016). http://dx.doi.org/10.1038/srep36543.

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42

Li, Xin, Xiao-wen Jiang, Hai-xiao Chu, Qing-chun Zhao, Huai-wei Ding, and Chao-hong Cai. "Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition." Chinese Herbal Medicines, December 2020. http://dx.doi.org/10.1016/j.chmed.2020.12.004.

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43

MORIWAKE, T., S. SAITO, H. TAMAI, H. MITSUDA, and M. INABA. "ChemInform Abstract: TOTAL SYNTHESIS OF KUKOAMINE A USING 2-METHYL-5,6-DIHYDRO-4H-1,3-OXAZINE AS A CARBOXAMIDE BUILDING BLOCK." Chemischer Informationsdienst 16, no. 27 (1985). http://dx.doi.org/10.1002/chin.198527160.

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44

Saller, J., C. List, H. Hübner, P. Gmeiner, T. Clark та M. Pischetsrieder. "Identifizierung von Kukoamin A und Kukoamin B als neuartige μ‐Opioidrezeptor‐Agonisten in Nachtschattengewächsen mittels virtuellem Screening". Lebensmittelchemie 75, S2 (2021). http://dx.doi.org/10.1002/lemi.202158021.

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45

Li, Yuan-Yuan, Rui Di, Wing-Leung Hsu, Ye-Qing Huang, and Hon-Yeung Cheung. "Quality control of Lycium chinense and Lycium barbarum cortex (Digupi) by HPLC using kukoamines as markers." Chinese Medicine 12, no. 1 (2017). http://dx.doi.org/10.1186/s13020-016-0121-x.

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