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Journal articles on the topic 'Kun T'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Pan, Xiangwen, Xia Li, Shuang Xi, Weiming Gong, and Mingxing Zhu. "A New Method for Predicting Pile Accumulated Deformation and Stiffness of Evolution Under Long-Term Inclined Cyclic Loading." Buildings 15, no. 4 (2025): 591. https://doi.org/10.3390/buildings15040591.

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Piles in marine environments are subjected to various loads of differing magnitudes and directions, and their long-term stability has attracted much attention. Most research focuses on lateral cyclic loading; there are few full-scale tests that consider the effects of cyclic loading at different inclined angles. A long-term inclined cyclic loading strategy was used to carry out laboratory tests to study different inclined angles on the pile. The results show that a smaller inclined angle (θL) or a larger pile–soil relative stiffness (T/L) results in wider and deeper sediment subsidence after 1

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Anraku, Itaru, Tracey J. Harvey, Richard Linedale, et al. "Kunjin Virus Replicon Vaccine Vectors Induce Protective CD8+ T-Cell Immunity." Journal of Virology 76, no. 8 (2002): 3791–99. http://dx.doi.org/10.1128/jvi.76.8.3791-3799.2002.

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ABSTRACT The ability of self-replicating RNA (replicon) vaccine vectors derived from the Australian flavivirus Kunjin (KUN) to induce protective αβ CD8+ T-cell responses was examined. KUN replicons encoding a model immunogen were delivered by three different vaccine modalities: (i) as naked RNA transcribed in vitro, (ii) as plasmid DNA constructed to allow in vivo transcription of replicon RNA by cellular RNA polymerase II (DNA based), and (iii) as replicon RNA encapsidated into virus-like particles. A single immunization with any of these KUN replicon vaccines induced CD8+ T-cell responses at

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Harvey, Tracey J., Itaru Anraku, Richard Linedale, et al. "Kunjin Virus Replicon Vectors for Human Immunodeficiency Virus Vaccine Development." Journal of Virology 77, no. 14 (2003): 7796–803. http://dx.doi.org/10.1128/jvi.77.14.7796-7803.2003.

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ABSTRACT We have previously demonstrated the ability of the vaccine vectors based on replicon RNA of the Australian flavivirus Kunjin (KUN) to induce protective antiviral and anticancer CD8+ T-cell responses using murine polyepitope as a model immunogen (I. Anraku, T. J. Harvey, R. Linedale, J. Gardner, D. Harrich, A. Suhrbier, and A. A. Khromykh, J. Virol. 76:3791-3799, 2002). Here we showed that immunization of BALB/c mice with KUN replicons encoding HIV-1 Gag antigen resulted in induction of both Gag-specific antibody and protective Gag-specific CD8+ T-cell responses. Two immunizations with

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Amrizal, Amrizal, and Siska Siska. "PENGARUH LATIHAN PLYOMETRIK MELOMPATI KUN DENGAN DUA KAKI KE SAMPING, SECARA ZIG-ZAG PADA SISWA PUTRA KELAS VIII A." Jurnal Ilmu Keolahragaan Undiksha 8, no. 2 (2020): 58. http://dx.doi.org/10.23887/jiku.v8i2.29551.

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This study aims to determine whether there is 1) The effect of plyometric training jumping over a kun with two legs to the side, 2) The effect of the plyometric training jumping over a kun with two legs in a zig-zag manner, 3) Comparison of the plyometric exercise jumping over a kun with two legs sideways and in a zig-zag manner on leg muscle power for male students of class VIII A SMP Negeri 1 Rambah, Rokan Hulu Regency. This type of research is a quasi experiment. The population was all male students of class VIII A SMP Negeri 1 Rambah, Rokan Hulu Regency, totaling 12 people. The sampling te

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Csáki-Bertók, Sára. "Minden Alapja (kun gzhi) a rDzogs pa chen po zhang zhung snyan rgyud bka’ rgyud skor bzhi alapján." Keréknyomok, no. 12 (2018): 5–55. http://dx.doi.org/10.56213/kerekny.12.2018.01.

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A rDzogs pa chen po zhang zhung snyan rgyud bka’ rgyud skor bzhi a tibeti jungdrung bőn hagyomány egyik legfontosabb dzogcsen szövegciklusa. Ez a tanítás megszakítatlan vonalon a dharmakayátó\ adódott tovább egészen napjainking. A dolgozat célja ezen értékes szövegen keresztül bemutatni a bőn dzogcsen filozófiának egy alapvető fontosságú pontját a kun gzhi-t, Minden Alapját. A kun gzhi (sz. a la ya) fogalmának tisztázása azért is fontos, mert más filozófiai rendszerekben is használják ugyanezt a fogalmat, de jelentésük eltérő, így számos félreértésre ad okot és a különféle tibeti filozófiai is

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6

Grønnum, Nina. "Danske lukkelyde: Perception, stemthed, fortis-lenis og lydskrift." NyS, Nydanske Sprogstudier, no. 67 (June 25, 2025): 63–92. https://doi.org/10.7146/nys.v1i67.153315.

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Det centrale tema i den debat om lydskriften af dansk der nyligt har fundet vej til Nydanske Sprogstudier og Danske Studier, kan indkredses til et spørgsmål om hvorvidt og i hvilket omfang valget af lydskriftsymboler kan og skal overholde principperne i The Handbook of the International Phonetic Association. Debatten suppleres her med en nærmere omtale af tre væsentlige forhold. (i) Dansk (b d ɡ) er inhærent ustemte, men lyder ikke som (p t k) i andre sprog. (ii) Den fraværende stemthed kan tydeliggøres med et diakritisk tegn, [◌̥ ] eller [◌̊ ], altså [b̥ d̥ ɡ̊ ], eftersom tegnet ikke kun brug

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7

Khromykh, Alexander A., Petra L. Sedlak, Kimberley J. Guyatt, Roy A. Hall, and Edwin G. Westaway. "Efficient trans-Complementation of the Flavivirus Kunjin NS5 Protein but Not of the NS1 Protein Requires Its Coexpression with Other Components of the Viral Replicase." Journal of Virology 73, no. 12 (1999): 10272–80. http://dx.doi.org/10.1128/jvi.73.12.10272-10280.1999.

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ABSTRACT Successful trans-complementation of the defective Kunjin virus (KUN) RNA FLdGDD with a deletion of the RNA polymerase motif GDD in the NS5 gene by using a BHK cell line, repBHK, that continuously produced a functionally active KUN replication complex (RC) from replicon RNA was recently reported (A. A. Khromykh, M. T. Kenney, and E. G. Westaway, J. Virol. 72:7270–7279, 1998). In order to identify whether this complementation of FLdGDD RNA was provided by the wild-type NS5 protein alone or with the help of other nonstructural (NS) proteins also expressed in repBHK cells, we generated BH

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8

Zhao, Yulin. "Positive Solutions for (k,n−k) Conjugate Multipoint Boundary Value Problems in Banach Spaces." International Journal of Mathematics and Mathematical Sciences 2012 (2012): 1–18. http://dx.doi.org/10.1155/2012/727468.

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By means of the fixed point index theory of strict-set contraction operator, we study the existence of positive solutions for the multipoint singular boundary value problem(-1)n-kun(t)=f(t,ut),0<t<1,n≥2,1≤k≤n-1,u(0)=∑i=1m-2‍aiu(ξi),u(i)(0)=u(j)(1)=θ,1≤i≤k−1,0≤j≤n−k−1in a real Banach spaceE, whereθis the zero element ofE,0<ξ1<ξ2<⋯<ξm-2<1,ai∈[0,+∞),i=1,2,…,m-2.As an application, we give two examples to demonstrate our results.

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Karkkola, Petri, and Matti Kuittinen. "Kipupystyvyyskyselyn ominaisuudet tuki- ja liikuntaelinkuntoutujilla." Psykologia 52, no. 4 (2025): 276–92. https://doi.org/10.62443/psykologia.v52i4.144814.

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Tutkimuksessa tarkasteltiin Pain Self-Efficacy Questionnaire -kyselyn (PSEQ) psykometrisiä ominaisuuksia sekä sen yhteyksiä mielialaoireiluun ja terveyteen liittyvään elämänlaatuun. Tutkittavana oli myös sen kyky selittää mielialaoireita ja terveyteen liittyvää elämänlaatua neuroottisuudesta riippumatta. Osallistujina oli 74 kuntoutujaa tuki- ja liikuntaelinkuntoutuskurssinsa ensimmäisellä jaksolla. PSEQ:n psykometristä rakennetta tarkasteltiin pääkomponenttianalyysin ja Cronbachin alfa-kertoimen avulla, sen toistomittausreliabiliteettia sisäkorrelaatiokertoimella ja jakson aikaista muutosta t

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Knox, Kennady, Devon Jeltema, Nicole Dobbs, et al. "Abstract LB209: Dynamic STING repression orchestrates immune cell functionality across development and maturation." Cancer Research 85, no. 8_Supplement_2 (2025): LB209. https://doi.org/10.1158/1538-7445.am2025-lb209.

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Abstract Stimulator of Interferon Genes (STING) is a critical component of the innate immune system. Mechanisms of STING-mediated type I interferon (IFN-I) signaling during infection are well studied in myeloid cells. However, homeostatic STING expression patterns and their regulation, particularly in lymphoid cells, are unknown. We established a Sting1IRES-EGFP reporter mouse to systematically characterize STING expression spatially in tissues and temporally along development of immune cells. Using this reporter and conditional Sting1 transgenic mouse models, we show that STING expression is

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Harvey, Tracey J., Wen Jun Liu, Xiang Ju Wang, et al. "Tetracycline-Inducible Packaging Cell Line for Production of Flavivirus Replicon Particles." Journal of Virology 78, no. 1 (2004): 531–38. http://dx.doi.org/10.1128/jvi.78.1.531-538.2004.

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ABSTRACT We have previously developed replicon vectors derived from the Australian flavivirus Kunjin that have a unique noncytopathic nature and have been shown to direct prolonged high-level expression of encoded heterologous genes in vitro and in vivo and to induce strong and long-lasting immune responses to encoded immunogens in mice. To facilitate further applications of these vectors in the form of virus-like particles (VLPs), we have now generated a stable BHK packaging cell line, tetKUNCprME, carrying a Kunjin structural gene cassette under the control of a tetracycline-inducible promot

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12

Bu, Ida Marie, and Guro Fagerbakke. "SAF-T innføres fra 1.1.2020 – er du klar?" Magma 23, no. 1 (2020): 34–37. http://dx.doi.org/10.23865/magma.v23.1221.

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Fra og med 1. januar 2020 må alle bokføringspliktige rapportere regnskapsdata til Skatteetaten i SAF-T. SAF-T er et standardformat som angir hvilke regnskapsdata som skal utveksles, og strukturen på de regnskapsdata som skal utveksles. Dette innebærer blant annet at bokføringspliktige må rapportere med samme kontoplan og de samme mva-kodene. Dersom virksomheten bruker andre kontonummer og mva-koder lokalt, må kontoplanen og mva-kodene mappes om til SAF-T-kontoplan og SAF-T-mva-koder og eksporteres til SAF-T-format. I første omgang gjelder plikten til å sende inn filer i SAF-T-format kun i for

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13

Chen, Rudong, and Zhichuan Zhu. "Strong convergence of approximation fixed points for nonexpansive nonself-mapping." International Journal of Mathematics and Mathematical Sciences 2006 (2006): 1–12. http://dx.doi.org/10.1155/ijmms/2006/16470.

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LetCbe a closed convex subset of a uniformly smooth Banach spaceE, andT:C→Ea nonexpansive nonself-mapping satisfying the weakly inwardness condition such thatF(T)≠∅, andf:C→Ca fixed contractive mapping. Fort∈(0,1), the implicit iterative sequence{xt}is defined byxt=P(tf(xt)+(1−t)Txt), the explicit iterative sequence{xn}is given byxn+1=P(αnf(xn)+(1−αn)Txn), whereαn∈(0,1)andPis a sunny nonexpansive retraction ofEontoC. We prove that{xt}strongly converges to a fixed point ofTast→0, and{xn}strongly converges to a fixed point ofTasαnsatisfying appropriate conditions. The results presented extend an

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14

Zhou, Minglang. "The Official National Language and Language Attitudes of Three Ethnic Minority Groups in China." Language Problems and Language Planning 23, no. 2 (1999): 157–74. http://dx.doi.org/10.1075/lplp.23.2.03zho.

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La oficiala lingvo kaj lingvaj sintenoj ĉe tri minoritataj grupoj en Cinio Rezulte de lingvoplanado, duono de la cent milionoj da etnominoritatanoj (EMN) en Ĉinio parolas iun version de Putonghua (PTH) kiel sian unuan aŭ duan lingvon. La nuna studo, utiligante sintenan/motivan enketaron kaj "pare maskitan" procedon, ekzamenis la taskojn fare de anoj de kazaka, ujgura kaj jia minoritatoj pri PTH kaj EMN-aj lingvoj, kaj dekdu varieblojn pri lernado kaj uzado de PTH. Analizoj de la rezultoj pere de unudirekta "ANOVA" kaj parspecimena testo t montras, ke a) integra orientigo kaj impreso de pekina-

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15

Kekkonen, Piia, Maarit Hyrkäs, Perttu Virkajärvi, et al. "Biokaasulaitoksen käsittelyjäännöksen, lannoituksen ja puna-apilapitoisuuden vaikutus nurmen satoon ja metaanintuottopotentiaaliin." Suomen Maataloustieteellisen Seuran Tiedote, no. 33 (January 31, 2016): 1–7. http://dx.doi.org/10.33354/smst.75169.

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Ravinteiden hyötykäyttö on yksi taloudellisen ja ympäristöystävällisen maatalouden lähtökohtia. Tämän tutkimuksen tarkoituksena oli selvittää, kuinka tehokkaasti ravinteita voidaan kierrättää, kun nurmea tuotetaan biokaasun raaka-aineeksi mahdollisimman pienillä ostopanoksilla. Kokeessa ravinnelähteinä käytettiin biokaasureaktorin käsittelyjäännöstä, väkilannoitteita ja biologista typensidontaa. Tarkastelussa ovat vuodet 2013 - 2015 ja koe toteutettiin Luonnonvarakeskus Maaningan toimipisteessä. Koe toteutettiin osaruutukokeena neljänä kerranteena. Pääruutuna olivat timotei-nurminataseos sekä

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Shodiyeva, Dildora. "INDOLIL SIRKA KISLOTA MIQDORINI ANIQLASH." GOLDEN BRAIN 1, no. 2 (2023): 321–24. https://doi.org/10.5281/zenodo.7556271.

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<em>Bakteriyalarning inkubatsiyasi ikkinchi kunidan boshlab 6 kun davomida ICK miqdori aniqlandi. Tadqiqotda Gordon va Weber usulidan foydalanildi. 15-20 ml hajmli probirkalarga filtrlangan 1,0 ml dan kultural suyuqlik olinib, unga 8,0 mln Salkovskiy reagent ( 50 ml 35 % li H2SO4 va 1 ml FeCl3 ning 0,5 Mli eritmalari aralashmasi) solindi, s</em><em>o‘</em><em>ngra aralashtirildi. Reaksion aralashma 30 minut davomida qoldirildi. Namunalar qizil-pushti rangga kirdi va tarkibidagi ICK miqdori SPEKOL 1300 markali SF ( spektrofotmetr) da, 450 nM t</em><em>o‘</em><em>lqin uzunligida yash

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Laurila, Jussi, and Risto Lauhanen. "Ruokohelven briketöinti." Suomen Maataloustieteellisen Seuran Tiedote, no. 23 (January 31, 2008): 1–7. http://dx.doi.org/10.33354/smst.75871.

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Tutkimuksen tavoitteena oli selvittää ruokohelven (Phalaris arundinacea) korjuun, murskauksen ja briketöinnin työvaiheita sekä kustannuksia. Lisäksi tarkasteltiin ruokohelpibrikettien ominaisuuksia ja soveltuvuutta lämmöntuotantoon. Ruokohelven logistisia virtoja viljelyksiltä loppukäyttöön selvitettiin Etelä-Pohjanmaan tavoite 2 –alueella yhteistyössä Kuortaneen energiaosuuskunnan kanssa. Projektin rahoittivat EU/EAKR, Etelä-Pohjanmaan TE-keskus, Seinäjoen ammattikorkeakoulu sekä mukana olleet käytännön tahot. Tuhannen kilogramman ruokohelpierän murskaamiseen kului aikaa 3 h 18 min. Murskan k

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Anhar, Anhar. "Pengaruh Latihan Zig-Zag Run Terhadap Kelincahan Menggiring Bola pada Atlet Tim Sepakbola." JURNAL PENDIDIKAN OLAHRAGA 13, no. 2 (2023): 21–26. http://dx.doi.org/10.37630/jpo.v13i2.1358.

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Sesuai hasil temuan dilapangan pada saat proses latihan berlangsung masih banyak ditemui atlet yang kurang dalam hal mempraktekan teknik-teknik dasar sepakbola, khususnya pada saat menggiring bola. Hal ini dapat dilihat pada saat atlet melakukan praktek dilapangan, atlet hanya memiliki kemampuan menggiring bola lari lurus ke depan dan waktu menggiring bola secara zig-zag membutuhkan waktu yang lama dan penyesuaian gerakan menggiring bola untuk melewati kun relatif kesulitan. Tujuan yang dicapai dalam penelitian ini adalah mengetahui pengaruh latihan zig-zag run terhadap kelincahan menggiring b

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Putu Istri Aryasuari, I. Gusti Ayu, I. Ketut Darma Laksana, and Ni Luh Nyoman Seri Malini. "JENIS-JENIS DAN BENTUK T-V YOBIKAKE OLEH REMAJA JEPANG." Linguistika: Buletin Ilmiah Program Magister Linguistik Universitas Udayana 25, no. 2 (2019): 112. http://dx.doi.org/10.24843/ling.2018.v25.i02.p03.

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This study aims to determine the types of greetings and forms of T-V greetings used by Japanese teenagers. Sources of data used are data in the form of questionnaires, list of questions, and supported by data sourced from Japanese movies and Japanese cartoons (anime). The theory used is the theory of types of yobikake according Hiromi and Theory T-V Brown-Gillman (1960). Methods and techniques of data provision are made with questionnaires and interview methods to Japanese adolescents. Methods and techniques of data analysis are performed by referential reference method. Methods and tech

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Dada, Hannah, Kun Do, Alexander Cartagena-Rivera, and Grégoire Altan-Bonnet. "Abstract 4132: Effect of mechanical cues on T cell killing of cancer cells." Cancer Research 83, no. 7_Supplement (2023): 4132. http://dx.doi.org/10.1158/1538-7445.am2023-4132.

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Abstract Cancer immunotherapies have focused on strategies to strengthen immune cell activation and effector function. These treatment strategies enhance the effector function of immune cells, particularly cytotoxic T cells (CTL), driving tumor eradication. Methods to improve the killing mechanisms of CTLs are not well studied and largely focused on assessing/strengthening the antigenic responses of T cells. We hypothesize that the mechanical landscape of CTL-tumor interactions can also drastically impact CTL cytotoxicity. By altering the physical context for T cell recognition of tumors, we m

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Backer-Grøndahl, Agathe, and Monica Martinussen. "Måleegenskaper ved den norske versjonen av Brief Problem Monitor (BPM)." PsykTestBarn 8, no. 1 (2018): 1–18. http://dx.doi.org/10.21337/0057.

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Beskrivelse: Brief Problem Monitor (BPM) er en kortversjon av kartleggingssystemet Achenbach System of Empirical Based Assessment (ASEBA). Instrumentet er utviklet for at man enkelt skal kunne følge med på barnets/ungdommens utvikling på eksternaliserende problemer, internaliserende problemer og oppmerksomhetsproblemer, inkludert eventuell endring etter en intervensjon. Det finnes tre versjoner; én for foreldre (BPM-P), én for lærere (BPM-T), og én for ungdom (BPM-Y). Det er 19 spørreskjemaledd (18 i BPM-T), og disse er hentet fra de tilsvarende lengre ASEBA-skjemaene (CBCL, TRF og YSR). BPM b

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Yu, Wen-Bin. "Valid publication of Turpinia pomifera var. minor (Staphyleaceae)." Phytotaxa 119, no. 1 (2013): 55. http://dx.doi.org/10.11646/phytotaxa.119.1.6.

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Turpinia Ventenat (1807: 3, non. cons.) is the largest genus of Staphyleaceae (Li et al. 2008). About 13 species are recorded from China, five of which are endemic. Turpinia pomifera var. minor C.C.Huang ex Hsu (1979: 358; see comments in Bartholomew & Zhou 2007) was firstly described in Flora Yunnanica. However, it was not validly published, because no specimen was listed in the protologue, which is contrary to Article 40.1 & 40.2 (McNeill et al. 2012). After consulting the herbarium of Kunming Institute of Botany (KUN), Chinese Academy of Sciences, we found that three gatherings (K.M

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Miftachul Amri, Muhammad, and Wisma Kurniawati. "PENGGUNAAN KARTU FLASHCARD PADA PEMBELAJARAN MEMBACA DAN MENULIS KANJI DI LPK." Jurnal Pendidikan Bahasa Jepang Undiksha 9, no. 2 (2023): 133–40. https://doi.org/10.23887/jpbj.v9i2.56662.

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Penelitian tentang keefektifan media pembelajaran (Kartu Kanji dan Kartu Flash) dalam membaca kanji pada siswa LPK tahun pelajaran 2017/2018. Tulisan Jepang menggunakan katakana, hiragana, dan kanji. Kanji sulit dikuasai oleh pembelajar bahasa Jepang. Oleh karena itu, pembelajar membutuhkan materi pembelajaran kanji. Kartu kanji & kartu flash adalah bahan pembelajaran. Karena kedua media pembelajaran tersebut mudah digunakan, dapat digunakan di semua jenjang pendidikan, menghemat waktu dan biaya, serta melibatkan peserta didik. Metode penelitian adalah pretest-posttest control group design

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Eerola, Tuomas, Topi Jäärvinen, Jukka Louhivuori, and Petri Toiviainen. "Statistical Features and Perceived Similarity of Folk Melodies." Music Perception 18, no. 3 (2001): 275–96. http://dx.doi.org/10.1525/mp.2001.18.3.275.

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Listeners are sensitive to pitch distributional information in music (N. Oram & L. L. Cuddy, 1995; C. L. Krumhansl, J. Louhivuori, P.Toiviainen, T. Jäärvinen, & T. Eerola, 1999). However, it is uncertain whether frequency-based musical features are sufficient to explain the similarity judgments that underlie listeners' classification processes. A similarity rating experiment was designed to determine the effectiveness of these features in predicting listeners' similarity ratings. The material consisted of 15 melodies representing five folk music styles. A multiple regression analysis s

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Wilson, Paula, Eliisa Ketola, Paavo Ahvenniemi, Mari J. Lehtonen, and Jari Valkonen. "Patovyöhyke perunaseitin (Rhizoctonia solani) biologisen torjunnan tutkimuksessa." Suomen Maataloustieteellisen Seuran Tiedote, no. 21 (January 31, 2006): 1–6. http://dx.doi.org/10.33354/smst.76135.

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Perunaseittiä aiheuttava maalevintäinen Rhizoctonia solani Kühn –sieni on moni-isäntäinen kasvipatogeeni, joka infektoi perunaa (Solanum tuberosum L.) joko siemenperunasta (seittirupi) tai maasta tulleen tartukkeen kautta. Perunaseitti heikentää satoa ja sen laatua, laskee tärkkelyspitoisuutta ja muuttaa mukulasadon kokojakaumaa. Epämuotoisten, halkeilleiden ja vihertyneiden mukuloiden osuus kasvaa. Tauti on levinnyt laajalle koko perunanviljelyalueella. Peittaus kemiallisilla torjunta-aineilla hoitaa siemenperunasta lähtöisin olevan seittitartunnan (seittirupi), mutta maalevintäiseen tartukke

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Gurevich-Schmidt, Yael, Kun Wang, Di Wu, et al. "Abstract 1411: Cell-type-specific transcriptomic immune aging clocks reveal clinically relevant associations with chronic illnesses including cancer." Cancer Research 84, no. 6_Supplement (2024): 1411. http://dx.doi.org/10.1158/1538-7445.am2024-1411.

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Abstract The aging of the immune system has profound implications for individual immune responses, yet precise quantification of immune age remains a challenge. Analyzing single-cell peripheral blood mononuclear cells (PBMC) transcriptomics data from 981 healthy individuals, we developed IMMClock (IMMune Clock), a human immune age clock derived from single cell transcriptomics. IMMClock is the first to accurately assess the age of three major immune cell types, CD8+ T cells, CD4+ T cells and NK cells, at the individual level. Testing the ability of these clocks to capture the dynamic aging pro

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Ma, Rulan, Dangcheng Xue, Yong Zhang та ін. "Abstract 2207: The prognostic role of γδ T cells in colorectal cancer and the establishment of related nomogram for predicting overall survival of the patients". Cancer Research 83, № 7_Supplement (2023): 2207. http://dx.doi.org/10.1158/1538-7445.am2023-2207.

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Abstract Objective: The aim of the present study was to explore the prognostic role of γδ T cells in colorectal cancer, and establish a nomogram for predicting the overall survival of the patients. Methods: Immunohistochemistry was performed to analyze the infiltration degree of γδ T cells in tumor and normal tissues of colorectal cancer. The relationship between γδ T cells infiltration in tumor tissues and the prognosis of patients with colorectal cancer were determined by survival analysis. Cox regression analysis was performed to detect the factors related to the prognosis of patients with

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Wang, Binbin, Kun Wang, Peng Jiang, and Eytan Ruppin. "Abstract 3169: Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures in melanoma enhances immunotherapy response prediction." Cancer Research 83, no. 7_Supplement (2023): 3169. http://dx.doi.org/10.1158/1538-7445.am2023-3169.

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Abstract Background: Cytotoxic T lymphocytes (CTL) play a crucial role in anti-cancer immunity. Progression of CTL to exhausted T lymphocytes (ETL) that overexpress inhibitory receptors can substantially decrease effector cytokines production and diminish cytolytic activity in tumor microenvironment (TME). However, while the activity levels of CTL and ETL are considered important determinants of immune checkpoint inhibitors (ICIs) response, it has been repeatedly observed that their predictive power is quite limited. Studying this conundrum on a large scale across the TCGA cohort, we find that

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Mele, Deanna A., Neil Grimster, Gayathri Bommakanti, et al. "Abstract 3453: First disclosure of a highly potent and selective HPK1 inhibitor that rescues T cell exhaustion." Cancer Research 83, no. 7_Supplement (2023): 3453. http://dx.doi.org/10.1158/1538-7445.am2023-3453.

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Abstract Immune checkpoint blockade (ICB) has revolutionized cancer therapy demonstrating durable responses in multiple tumor types, however only a subset of patients respond, in part due to mechanisms that drive T cell dysfunction. HPK1 is a key inhibitory signaling node associated with T cell exhaustion that is activated in response to T cell receptor engagement (signal 1). HPK1 is thus distinct from inhibitory checkpoint receptors which require surface receptor expression, antigen recognition (signal 1) and costimulatory engagement (signal 2) for activity. HPK1 therefore has potential for b

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Liu, Yanli, Hao Liu, and Kun Cheng. "Abstract 600: Discovery of a single-domain antibody fragment targeting PD-L1 for cancer immunotherapy." Cancer Research 82, no. 12_Supplement (2022): 600. http://dx.doi.org/10.1158/1538-7445.am2022-600.

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Abstract Immunotherapy has shown enormous promise for cancer treatment. The use of Antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in cancer immunotherapy. Single-domain antibody fragment (sdAb) is an antibody fragment composed of a single variable domain of the heavy chain. sdAb is the smallest antibody fragment (15 kDa) that maintains the similar antigen-binding affinity. sdAbs show many advantages over monoclonal antibodies such as small size, low immunogenicity, ease of production, and ease of modification, making sdAbs promising candidates for

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Alakukku, Laura, Antti Ristolainen, and Tapio Salo. "Typen ja fosforin peltotase savimaan muokkauksen keventyessä." Suomen Maataloustieteellisen Seuran Tiedote, no. 26 (January 31, 2010): 1–6. http://dx.doi.org/10.33354/smst.75818.

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Kahdessa pitkäaikaisessa savimaan kenttäkokeessa tutkittiin ohran typpi ja fosforitasetta muokkausintensiteetin vähetessä kynnöstä suorakylvöön. Kentät perustettiin Jokioisiin aito ja hiuesavimalle vuosina 2000 ja 2001. Verratut muokkausmenetelmät olivat käytännön viljelyssä yleisimpiä. Syysmuokkauskäsittelyt olivat: kyntö (20–25 cm syvyyteen, P), sänkimuokkaus (10–15 cm, S) ja pellon jättäminen sängelle (keväällä suorakylvö, N). Keväällä aitosavimaan kokeessa kasvusto perustettiin kolmella tavalla: (A) jyrsinkylvö (yhden ajokerran menetelmä, tavallinen kylvölannoitin, (B), kylvö kevennettyy

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Chen, Yiyun, Moksha H. Desai, Zachary J. Ehlinger, et al. "Abstract 7123: Unravelling temporal dynamics of GD2-CAR T cell therapy in H3K27M-mutant diffuse midline glioma through comprehensive single-cell and multi-omic profiling." Cancer Research 85, no. 8_Supplement_1 (2025): 7123. https://doi.org/10.1158/1538-7445.am2025-7123.

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Abstract H3K27M-mutant diffuse midline gliomas (DMG) are aggressive pediatric brain tumors with dismal prognoses and no effective treatments. GD2, a disialoganglioside overexpressed on DMG cells, is a promising target for chimeric antigen receptor (CAR) T cell therapy. In Arm A of the Phase I clinical trial (NCT04196413), 12 patients (11 on study) received GD2-CAR T cells through an initial intravenous (IV) infusion, and if patients had clinical or radiographic improvement, they subsequently received intracerebroventricular (ICV) administrations. This regimen achieved clinical benefit in ten p

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Maharaj, Kamira, Melanie Mediavilla-Varela, John J. Powers, et al. "Abstract 5496: Efficacy and immune profiling of PI3K delta inhibitor zandelisib (ME-401) in a preclinical chronic lymphocytic leukemia (CLL) model." Cancer Research 82, no. 12_Supplement (2022): 5496. http://dx.doi.org/10.1158/1538-7445.am2022-5496.

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Abstract Phosphatidylinositol-3 kinase (PI3K) delta signaling is essential for CLL B cell survival and proliferation. Several PI3K inhibitors are approved for treatment of CLL, but PI3K inhibitor-induced alterations in T cell function have been correlated with immune-related adverse events (irAEs). Zandelisib is a novel selective PI3Kδ inhibitor in clinical development with an intermittent dosing schedule for treatment of B cell malignancies. Here, we investigated the dynamic immunomodulatory properties of zandelisib alone or in combination with BTK inhibitor ibrutinib in normal human T cells,

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Yun, Kun, R. Leo Sakemura, Ismail Can, et al. "Abstract 6103: BCMA CAR engineering arms T cells with superior functions post ex vivo stimulation by MUC1 peptide-loaded autologous PBMCs." Cancer Research 85, no. 8_Supplement_1 (2025): 6103. https://doi.org/10.1158/1538-7445.am2025-6103.

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Abstract Chimeric antigen receptor T (CART) cell therapy has shown clinical successes in B cell hematological malignancies. Two B cell maturation antigen (BCMA)-directed CART cell therapies treating multiple myeloma (MM) were approved by FDA but most patients relapse within 1-2 years. Ex vivo-expanded antigen specific T cells as cancer treatment rely on TCR-mediated killing of tumors. We hypothesized that arming ex vivo enriched tumor-specific T cells with CARs targeting a different antigen improves T cell functions. First, we expanded mucin 1 (MUC1)-activated T cells from patients with MM thr

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Redaktionen. "At arbejde i det offentlige — velfærdsstat og velfærdsarbejde under forandring." Tidsskrift for Arbejdsliv 14, no. 4 (2012): 5–9. http://dx.doi.org/10.7146/tfa.v14i4.108921.

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At arbejde i det offentlige — velfærdsstat og velfærdsarbejde under forandring A t arbejde i det offentlige var for årtier siden forbundet med høj status; offentligt ansatte var betroede medarbejdere, de havde via deres virke et væsentligt ansvar for velfærdsstaten og dens borgere. At give tryghed i ansættelsen-blandt andet via tjenestemandsansættelse af dele af de offentligt ansatte-var et led i at sikre stabilitet i staten (kerstrøm 2001). Og vi så sammen med fremvæksten af nye velfærdsprofessioner og-fag etableringen af det, man kan kalde et offentligt etos, altså en særlig moral, der er re

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Sipilä, Timo P., Kim Yrjälä, Laura Alakukku, and Ansa Palojärvi. "Muokkausmenetelmien vaikutus maaperän mikrobistoon ja niiden tarjoamiin ekosysteemipalveluihin." Suomen Maataloustieteellisen Seuran Tiedote, no. 28 (January 31, 2012): 1–5. http://dx.doi.org/10.33354/smst.75636.

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Maatalous kohtaa ilmastonmuutoksen myötä entistä suurempia ympäristöhaasteita. Eroosio- ja ravinnekuorma vesistöihin kasvaa, mikäli talvet muuttuvat ennustetulla tavalla lauhemmiksi ja sateisemmiksi. Kasvipeitteisyys suojaa maan pintaa vähentäen eroosio- ja ravinnehuuhtoumariskiä, mutta kasvinjäte voi vaikeuttaa viljelyä ja luoda suotuisat olosuhteet maa- ja kasvinjätelevinteisille kasvitaudeille. SUCCESS-projekti toteutettiin osana MTT:n Muuttuva ilmasto ja maatalous tutkimusohjelmaa (2009–2012) ja Helsingin yliopiston Globaalin ympäristömuutoksen tutkimusohjelmaa (2008–2011). Tutkimuksen tav

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Stoliarova, Olga E. "Cognitive Humility and Scientific Progress." Voprosy Filosofii, no. 12 (2020): 139–42. http://dx.doi.org/10.21146/0042-8744-2020-12-139-142.

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What is cognitive (scientific) humility? Is it a virtue or vice? We consider the manifestations of cognitive humility highlighted by I.T. Kasavin, placing them in two contexts – normal science and revolutionary science. Such cognitive virtues as the search for justification, knowledge as confidence (knowledge through testimony), recognition of the limitations of knowledge, and selflessness can work to the benefit of both normal and revolutionary science. The victorious scientific paradigm retroactively justifies its creators, turning them into knights without fear and reproach. Accordingly, th

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Lee, Kiri, and Young-mee Yu Cho. "Beyond ‘power and solidarity’." Korean Linguistics 15, no. 1 (2013): 73–100. http://dx.doi.org/10.1075/kl.15.1.04lee.

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This study examines the nominal address terms in Korean and Japanese and argues that the notion of ‘Intimacy’ plays a crucial role in choosing an appropriate nominal address term in both languages. In the past several decades, a long list of researchers working in diverse languages have evaluated the validity of the Power and Solidarity semantics proposed by Brown and Gilman (1960), which provided a ground-breaking framework to account for the selection of pronominal address terms in the T-V languages. Building on the Power and Solidarity semantics, we propose to fine-tune it by adding Intimac

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Wang, Yufei, Alicia Buck, Gabriella Kastrunes, et al. "Abstract 886: Fine-tuned CAIX targeted CAR-T cells exhibit superior efficacy and mitigate on-target off-tumor side effects." Cancer Research 83, no. 7_Supplement (2023): 886. http://dx.doi.org/10.1158/1538-7445.am2023-886.

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Abstract Chimeric Antigen Receptor (CAR) T cell therapy is a new type of “living drug” that has proven to be a powerful immunotherapy for hematologic malignancies. To date, there are six CAR-T products approved by the FDA for hematologic malignancies, four targeting CD19, and two targeting B-cell maturation antigen (BCMA). However, this success has not yet been transferred to solid tumors. A major hurdle is the on-target off-tumor toxicities due to the shared expression of target antigen on normal tissues. Carbonic anhydrase IX (CAIX) is highly expressed in clear cell renal cell carcinoma (ccR

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Huynh, Truc Ngoc, Victoria Wang, Tait Shanafelt, et al. "Abstract 3849: Frontline ibrutinib-based therapy enhances CART cell functions in patients with CLL: Analysis of the phase 3 randomized clinical trial ECOG-ACRIN E1912." Cancer Research 84, no. 6_Supplement (2024): 3849. http://dx.doi.org/10.1158/1538-7445.am2024-3849.

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Abstract Introduction: Despite the remarkable activity of CD19-directed chimeric antigen receptor T cell therapy (CART19), durable remissions remain low, especially in chronic lymphocytic leukemia (CLL). Ibrutinib is an oral irreversible inhibitor of Bruton’s tyrosine kinase and is a first line therapy for CLL. Preclinical and early clinical data indicate that ibrutinib plus CART19 may be synergistic through inhibition of IL2-inducible T cell kinase. To systematically study the effects of prior ibrutinib treatment on subsequent CART functions, we utilized blood samples from the pivotal clinica

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Zarkesh Esfahani, Sayyed Hamid, Kun Luo, Michael Wagner, et al. "Abstract 3184: Development of novel anti-mesothelin CAR-T cells for the treatment of solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 3184. https://doi.org/10.1158/1538-7445.am2025-3184.

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Abstract Introduction: Mesothelin (MSLN) is overexpressed in many human solid tumors and absent from most healthy tissues. Despite multiple clinical trials, little success has been achieved by MSLN CARs. Shed MSLN accumulates in patient sera and tumor draining fluids, potentially blocking MSLN CAR function (1, 2). Alpaca-derived VHHs are an attractive option for CAR design that offer exquisite epitope targeting and the potential to circumvent the challenges of cleaved and shed MSLN. Methods: Eight alpaca-derived VHHs targeting the MSLN membrane-proximal region were incorporated into a second-g

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Zhu, Xizhou, Alfredo Perales-Puchalt, Krzysztof Wojtak, et al. "Abstract 3573: DNA immunotherapy targeting BARF1 demonstrates therapeutic impact in novel murine carcinoma models expressing EBV latent antigens." Cancer Research 82, no. 12_Supplement (2022): 3573. http://dx.doi.org/10.1158/1538-7445.am2022-3573.

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Abstract Epstein Barr Virus (EBV) latent infection is associated with multiple types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV+ malignancies, suggesting additional targets might be important. BamHI-A rightward frame 1 (BARF1) is an EBV antigen that is highly expressed in EBV-associated gastric carcinoma (EBVaGC) and EBV+ nasopharyngeal carcinoma (NPC) and has not been evaluated as an antigen in the context of therapeutic immunization. Here, we developed a synthetic DNA-based expression cassette as immunotherapy tar

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Aizemaiti, Rusidanmu, Huifang Zhang, Changbin Zhu, et al. "Abstract 625: Remodeling of the tumor microenvironment in esophageal squamous cell carcinoma by neoadjuvant immunochemotherapy and its impact on therapeutic efficacy." Cancer Research 84, no. 6_Supplement (2024): 625. http://dx.doi.org/10.1158/1538-7445.am2024-625.

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Abstract Background: Patients with local advanced esophageal squamous cell carcinoma (ESCC) benefited from neoadjuvant immunochemotherapy (NAI) with 22%-55% of complete pathological responses (pCR). While unpredicted therapeutic resistance hampered prognosis of these patients. Thus, this study aimed to investigate tumor microenvironment (TME) remodeling pre- and post-NAI identifying predictive biomarkers and potential targets for patients with resistance to NAI. Methods: 65 patients with locally advanced ESCC, who were treated with neoadjuvant anti-PD-1 antibody and platinum-based chemotherapy

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Aberin, Marvin A., Yu-Ling (Pony) Lee, Xin-Guo Hsu, et al. "Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression." Cancer Research 83, no. 7_Supplement (2023): 3646. http://dx.doi.org/10.1158/1538-7445.am2023-3646.

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Abstract Despite advancements of immunotherapy against various cancers, breast cancer still retains poor response to immune checkpoint blockade (ICB) therapy. Therefore, the identification of promising target or new strategy to enhance ICB therapy in breast cancer is crucial. Here, we uncover that the DNA-damaging potential of tamoxifen (TAM) can shape the unfavorable but ready-to-fire tumor immune microenvironment in breast cancer. We discover that a long-term TAM administration unexpectedly induces JAK/STAT signaling and Type I interferon (IFN)-stimulated gene expression to promote T-cell in

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Lee, Pony Yu-Ling, Marvin A. Aberin, Chien-Chang Shen, et al. "Abstract 5953: Reshaping the tumor microenvironment: new application of tamoxifen in triple negative breast cancer immunomodulation." Cancer Research 83, no. 7_Supplement (2023): 5953. http://dx.doi.org/10.1158/1538-7445.am2023-5953.

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Abstract Tamoxifen is a widely known estrogen receptor (ER) modulator which has been employed in adjuvant treatment of ER+ breast cancer for over 30 years. Interestingly, clinical observations reveal that tamoxifen is capable of inducing regression of some tumors lacking ER expression whereas tamoxifen is also capable of increasing host resistance against cancer in an ER-independent mechanism. These findings suggest the immunomodulatory effects of tamoxifen may be ER-independent, but little is known about the underlying mechanism and the potential clinical implication. Recently, we identified

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Steimle, Brittany L., Peirong Hu, Ngoc Tran, et al. "Abstract 2913: Co-expression of extracellular matrix enzymes heparanase or PH-20 augments the anti-tumor efficacy of folate receptor 1-targeting CAR T cells in an ovarian cancer model." Cancer Research 84, no. 6_Supplement (2024): 2913. http://dx.doi.org/10.1158/1538-7445.am2024-2913.

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Abstract Introduction: The tumor extracellular matrix (ECM) is a physical barrier which obstructs trafficking of CAR T cells to tumors. We hypothesize that co-expressing ECM remodeling/degrading enzymes heparanase (HPSE) or PH-20 with a CAR directed against folate receptor 1 (FolR1) will overcome the physical tumor microenvironment barrier and improve anti-tumor efficacy of anti-FolR1 CAR in a human ovarian cancer model. Methods: ECM CARs were constructed by combining anti-FolR1 ScFv with a CD8 hinge and transmembrane domain, 4-1BB, and CD3ζ endodomains, followed by a P2A element and full-leng

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Wang, Youping, Wenjing Yang, Wanwan Chen, et al. "Abstract 3420: Coordinated stimulation of APC and T cell functions by first-in-class, tri-specific AN8025 for next-generation cancer immunotherapy." Cancer Research 85, no. 8_Supplement_1 (2025): 3420. https://doi.org/10.1158/1538-7445.am2025-3420.

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Abstract Background: Immune checkpoint inhibitors (ICI), the cornerstone of current immunotherapies, primarily target T cells to reinvigorate the immune system against tumors. Recently, combinatory approaches, particularly in the form of bi-specific molecules such as Akeso’s PD-1/VEGF and Innovent’s PD-1/IL2, have garnered significant interest for their potential to deliver superior clinical efficacy beyond the ICI era. Building on this paradigm, AN8025 emerges as a tri-specific antibody fusion protein derived from a clinically validated and approved anti-PD-L1 antibody, fused with functionall

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Alahmari, Mohammed, Umar-Farouk Mamani, Yuhan Guo, et al. "Abstract LB194: A small molecular-weight anti-lag-3 peptide inhibits colon tumor growth." Cancer Research 83, no. 8_Supplement (2023): LB194. http://dx.doi.org/10.1158/1538-7445.am2023-lb194.

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Abstract Lymphocyte activation gene-3 (LAG-3) has emerged as a promising target for cancer immunotherapy. It is expressed on activated CD4+ and CD8+ T cells, and on the surface of B cells, natural killer cells, and dendritic cells (DC). It has also been found to be highly expressed on activated T cells upon treatment with monoclonal antibodies targeting the PD-1/PD-L1 pathway, which may explain the resistance mechanism of monotherapy. Several anti-LAG-3 antibodies are being examined in clinical trials to treat different types of cancers. Despite their specificity and affinity, antibody-based c

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Wang, Binbin, Robert Saddawi-konefka, Lauren M. Clubb, et al. "Abstract 6277: A time-series mouse model identifies an early post-treatment effective liquid biomarker of ICB response in human head and neck cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6277. https://doi.org/10.1158/1538-7445.am2025-6277.

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Abstract Background & Approach: Immune checkpoint blockade (ICB) therapy has shown promise for head and neck squamous cell carcinoma (HNSCC); however, response rates remain limited, with only a subset of patients exhibiting significant clinical benefits. Identifying non-invasive liquid biomarkers to predict ICB response is crucial for optimizing patient selection and treatment strategies. In this study, we generate and analyze time-series RNA and T-cell receptor (TCR) sequencing data from blood in a murine HNSCC model treated with anti-PD-1 therapy to identify potential liquid biomarkers p

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HHKG, Redactie. "'T kan verkeren." Ghendtsche Tydinghen 46, no. 2 (2017): 159–60. http://dx.doi.org/10.21825/gt.v46i2.16932.

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