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Relevant bibliographies by topics / L-alanine Spacer

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Journal articles

Academic literature on the topic 'L-alanine Spacer'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "L-alanine Spacer"

1

Nuno A.G. Graça, Bogac Ercig, Leydi Carolina Velásquez Pereira, et al. "Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura." Haematologica 105, no. 11 (2019): 2619–30. http://dx.doi.org/10.3324/haematol.2019.226068.

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Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura (iTTP) commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY). In this study we present a detailed contribution of each residue in this epitope for autoantibody binding. Different panels of mutations were introduced here to create a large collection of full-length ADAMTS13 variants comprising conservative (Y←→F), semi-conservative (Y/F→L), non-conservative (Y/F→N) or alanine (Y/F/R→A) substitutions. Previously reported Gain-of-Function (GoF, KYKFF) and truncated ‘MDTCS’ variants were also included.

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2

Nishiyama, Yasuhiro, Tetsuya Yoshida, Tomonori Mori, Shigeru Ishii, and Keisuke Kurita. "Asymmetric reduction with chitosan/dihydronicotinamide conjugates: influence of l-alanine spacer arms on reducing performance." Reactive and Functional Polymers 37, no. 1-3 (1998): 83–91. http://dx.doi.org/10.1016/s1381-5148(97)00142-9.

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3

Kurita, Keisuke, Seiji Iwawaki, Shigeru Ishii, and Shin-Ichiro Nishimura. "Introduction of poly(L-alanine) side chains into chitin as versatile spacer arms having a terminal free amino group and immobilization of nadh active sites." Journal of Polymer Science Part A: Polymer Chemistry 30, no. 4 (1992): 685–88. http://dx.doi.org/10.1002/pola.1992.080300421.

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4

Bao, Jialing, Khalil Bdeir, Don L. Siegel, Douglas B. Cines, and X. Long Zheng. "Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis." Blood 124, no. 21 (2014): 599. http://dx.doi.org/10.1182/blood.v124.21.599.599.

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Abstract Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal syndrome associated with severe deficiency of plasma ADAMTS13 activity resulting from either mutations or autoantibodies. However, patients with severe ADAMTS13 deficiency do not always develop TTP. Rather, a trigger, such as infection or inflammation, often precedes the onset of the TTP syndrome. We hypothesized that antimicrobial human neutrophil peptides 1-3 (HNPα1-3) or α-defensins, the most abundant proteins in the granules of neutrophils, which are released at site of inflammation, activate platelets, and inhibit f

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5

Pillai, Vikram G., Jialing Bao, Jenny McDaniel, et al. "Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease." Blood 126, no. 23 (2015): 105. http://dx.doi.org/10.1182/blood.v126.23.105.105.

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Abstract Human neutrophil peptides (HNPs) or alpha (α)-defensins are a family of small antimicrobial peptides which play important roles in innate immunity against invading bacteria, fungi, and viruses. HNPs contain 29-33 amino acid residues which share a distinct pattern of disulfide bonding. HNPs can be further subdivided into myeloid (HNPs 1-4) and enteric (HD5-6) forms. HNPs-1, -2, and -3 are structurally identical except for the first amino acid residue and are predominantly expressed in human neutrophils from which they are released at sites of infection or inflammation. Previous studies

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6

Ando, Tadashi, and Koji Tamura. "Mechanism of Chiral-Selective Aminoacylation of an RNA Minihelix Explored by QM/MM Free-Energy Simulations." Life 13, no. 3 (2023): 722. http://dx.doi.org/10.3390/life13030722.

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Aminoacylation of a primordial RNA minihelix composed of D-ribose shows L-amino acid preference over D-amino acid without any ribozymes or enzymes. This preference in the amino acylation reaction likely plays an important role in the establishment of homochirality in L-amino acid in modern proteins. However, molecular mechanisms of the chiral selective reaction remain unsolved mainly because of difficulty in direct observation of the reaction at the molecular scale by experiments. For seeking a possible mechanism of the chiral selectivity, quantum mechanics/molecular mechanics (QM/MM) umbrella

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7

Dorm, Bruna Carolina, Mônica Rosas Costa Iemma, Benedito Domingos Neto, et al. "Synthesis and Biological Properties of Alanine-Grafted Hydroxyapatite Nanoparticles." Life 13, no. 1 (2022): 116. http://dx.doi.org/10.3390/life13010116.

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Hydroxyapatite attracts great attention as hard tissues implant material for bones and teeth. Its application in reconstructive medicine depends on its biocompatibility, which is in a function of composition and surface properties. The insertion of a protein element in the composition of implants can improve the cell adhesion and the osseointegration. Having this in mind, the proposal of this work was to develop L-alanine-grafted hydroxyapatite nanoparticles and to study their biocompatibility. Two L-alanine sources and three grafting methods were used for hydroxyapatite surface functionalizat

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8

Goskulwad, Santosh P., Mohammad Al Kobaisi, Duong Duc La, et al. "Supramolecular Chiral Helical Ribbons of Tetraphenylethylene-Appended Naphthalenediimide Controlled by Solvent and Induced by l - and d -Alanine Spacers." Chemistry - An Asian Journal 13, no. 24 (2018): 3947–53. http://dx.doi.org/10.1002/asia.201801421.

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9

Garcia, Adrien D., Cornelia Meinert, Friedrich Finger, Uwe J. Meierhenrich, and Ewald Hejl. "Racemate Resolution of Alanine and Leucine on Homochiral Quartz, and Its Alteration by Strong Radiation Damage." Life 11, no. 11 (2021): 1222. http://dx.doi.org/10.3390/life11111222.

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Homochiral proteins orchestrate biological functions throughout all domains of life, but the origin of the uniform l-stereochemistry of amino acids remains unknown. Here, we describe enantioselective adsorption experiments of racemic alanine and leucine onto homochiral d- and l-quartz as a possible mechanism for the abiotic emergence of biological homochirality. Substantial racemate resolution with enantiomeric excesses of up to 55% are demonstrated to potentially occur in interstitial pores, along grain boundaries or small fractures in local quartz-bearing environments. Our previous hypothesi

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10

Eder, Piotr, Agnieszka Permoda-Osip, Przemyslaw Majewski, Krzysztof Linke, and Janusz K. Rybakowski. "Agomelatine-induced liver injury in a patient with choledocholithiasis." Acta Neuropsychiatrica 27, no. 1 (2014): 56–59. http://dx.doi.org/10.1017/neu.2014.28.

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ObjectiveA case of agomelatine-induced hepatotoxicity is described in a 47-year female patient who has received the drug, 25 mg/day, for 4 months, for the treatment of depression.MethodsThe patient was admitted to the Department of Gastroenterology because of fatigue and nausea, with concomitant elevation of alanine aminotransferase (ALT), 550 U/L, and asparagine aminotransferase (AST), 300 U/L.ResultsLiver biopsy showed diffuse lymphocyte infiltration in the dilated portal spaces without lesion of hepatic lobules. Several weeks after stopping agomelatine, the liver enzymes returned to normal.

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