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Journal articles on the topic 'L-alanine Spacer'

Author: Grafiati

Published: 6 September 2023

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1

Nuno A.G. Graça, Bogac Ercig, Leydi Carolina Velásquez Pereira, et al. "Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura." Haematologica 105, no. 11 (2019): 2619–30. http://dx.doi.org/10.3324/haematol.2019.226068.

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Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura (iTTP) commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY). In this study we present a detailed contribution of each residue in this epitope for autoantibody binding. Different panels of mutations were introduced here to create a large collection of full-length ADAMTS13 variants comprising conservative (Y←→F), semi-conservative (Y/F→L), non-conservative (Y/F→N) or alanine (Y/F/R→A) substitutions. Previously reported Gain-of-Function (GoF, KYKFF) and truncated ‘MDTCS’ variants were also included.

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2

Nishiyama, Yasuhiro, Tetsuya Yoshida, Tomonori Mori, Shigeru Ishii, and Keisuke Kurita. "Asymmetric reduction with chitosan/dihydronicotinamide conjugates: influence of l-alanine spacer arms on reducing performance." Reactive and Functional Polymers 37, no. 1-3 (1998): 83–91. http://dx.doi.org/10.1016/s1381-5148(97)00142-9.

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3

Kurita, Keisuke, Seiji Iwawaki, Shigeru Ishii, and Shin-Ichiro Nishimura. "Introduction of poly(L-alanine) side chains into chitin as versatile spacer arms having a terminal free amino group and immobilization of nadh active sites." Journal of Polymer Science Part A: Polymer Chemistry 30, no. 4 (1992): 685–88. http://dx.doi.org/10.1002/pola.1992.080300421.

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4

Bao, Jialing, Khalil Bdeir, Don L. Siegel, Douglas B. Cines, and X. Long Zheng. "Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis." Blood 124, no. 21 (2014): 599. http://dx.doi.org/10.1182/blood.v124.21.599.599.

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Abstract Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal syndrome associated with severe deficiency of plasma ADAMTS13 activity resulting from either mutations or autoantibodies. However, patients with severe ADAMTS13 deficiency do not always develop TTP. Rather, a trigger, such as infection or inflammation, often precedes the onset of the TTP syndrome. We hypothesized that antimicrobial human neutrophil peptides 1-3 (HNPα1-3) or α-defensins, the most abundant proteins in the granules of neutrophils, which are released at site of inflammation, activate platelets, and inhibit f

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5

Pillai, Vikram G., Jialing Bao, Jenny McDaniel, et al. "Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease." Blood 126, no. 23 (2015): 105. http://dx.doi.org/10.1182/blood.v126.23.105.105.

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Abstract Human neutrophil peptides (HNPs) or alpha (α)-defensins are a family of small antimicrobial peptides which play important roles in innate immunity against invading bacteria, fungi, and viruses. HNPs contain 29-33 amino acid residues which share a distinct pattern of disulfide bonding. HNPs can be further subdivided into myeloid (HNPs 1-4) and enteric (HD5-6) forms. HNPs-1, -2, and -3 are structurally identical except for the first amino acid residue and are predominantly expressed in human neutrophils from which they are released at sites of infection or inflammation. Previous studies

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6

Ando, Tadashi, and Koji Tamura. "Mechanism of Chiral-Selective Aminoacylation of an RNA Minihelix Explored by QM/MM Free-Energy Simulations." Life 13, no. 3 (2023): 722. http://dx.doi.org/10.3390/life13030722.

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Aminoacylation of a primordial RNA minihelix composed of D-ribose shows L-amino acid preference over D-amino acid without any ribozymes or enzymes. This preference in the amino acylation reaction likely plays an important role in the establishment of homochirality in L-amino acid in modern proteins. However, molecular mechanisms of the chiral selective reaction remain unsolved mainly because of difficulty in direct observation of the reaction at the molecular scale by experiments. For seeking a possible mechanism of the chiral selectivity, quantum mechanics/molecular mechanics (QM/MM) umbrella

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7

Dorm, Bruna Carolina, Mônica Rosas Costa Iemma, Benedito Domingos Neto, et al. "Synthesis and Biological Properties of Alanine-Grafted Hydroxyapatite Nanoparticles." Life 13, no. 1 (2022): 116. http://dx.doi.org/10.3390/life13010116.

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Hydroxyapatite attracts great attention as hard tissues implant material for bones and teeth. Its application in reconstructive medicine depends on its biocompatibility, which is in a function of composition and surface properties. The insertion of a protein element in the composition of implants can improve the cell adhesion and the osseointegration. Having this in mind, the proposal of this work was to develop L-alanine-grafted hydroxyapatite nanoparticles and to study their biocompatibility. Two L-alanine sources and three grafting methods were used for hydroxyapatite surface functionalizat

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8

Goskulwad, Santosh P., Mohammad Al Kobaisi, Duong Duc La, et al. "Supramolecular Chiral Helical Ribbons of Tetraphenylethylene-Appended Naphthalenediimide Controlled by Solvent and Induced by l - and d -Alanine Spacers." Chemistry - An Asian Journal 13, no. 24 (2018): 3947–53. http://dx.doi.org/10.1002/asia.201801421.

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9

Garcia, Adrien D., Cornelia Meinert, Friedrich Finger, Uwe J. Meierhenrich, and Ewald Hejl. "Racemate Resolution of Alanine and Leucine on Homochiral Quartz, and Its Alteration by Strong Radiation Damage." Life 11, no. 11 (2021): 1222. http://dx.doi.org/10.3390/life11111222.

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Homochiral proteins orchestrate biological functions throughout all domains of life, but the origin of the uniform l-stereochemistry of amino acids remains unknown. Here, we describe enantioselective adsorption experiments of racemic alanine and leucine onto homochiral d- and l-quartz as a possible mechanism for the abiotic emergence of biological homochirality. Substantial racemate resolution with enantiomeric excesses of up to 55% are demonstrated to potentially occur in interstitial pores, along grain boundaries or small fractures in local quartz-bearing environments. Our previous hypothesi

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10

Eder, Piotr, Agnieszka Permoda-Osip, Przemyslaw Majewski, Krzysztof Linke, and Janusz K. Rybakowski. "Agomelatine-induced liver injury in a patient with choledocholithiasis." Acta Neuropsychiatrica 27, no. 1 (2014): 56–59. http://dx.doi.org/10.1017/neu.2014.28.

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ObjectiveA case of agomelatine-induced hepatotoxicity is described in a 47-year female patient who has received the drug, 25 mg/day, for 4 months, for the treatment of depression.MethodsThe patient was admitted to the Department of Gastroenterology because of fatigue and nausea, with concomitant elevation of alanine aminotransferase (ALT), 550 U/L, and asparagine aminotransferase (AST), 300 U/L.ResultsLiver biopsy showed diffuse lymphocyte infiltration in the dilated portal spaces without lesion of hepatic lobules. Several weeks after stopping agomelatine, the liver enzymes returned to normal.

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11

Izumi, Yudai, and Kazumichi Nakagawa. "Quantum Yields of Decomposition and Homo-Dimerization of Solid L-Alanine Induced by 7.2 eV Vacuum Ultraviolet Light Irradiation: An Estimate of the Half-Life of L-Alanine on the Surface of Space Objects." Origins of Life and Evolution of Biospheres 41, no. 4 (2011): 385–95. http://dx.doi.org/10.1007/s11084-011-9237-2.

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12

Conte, E., G. Fanfani, M. Pieralice, R. Amerotti, and A. D'Addabbo. "Investigation on the asymmetrical induced yields in90Sr-90Y-beta-irradiated D- and L-alanines." Origins of Life and Evolution of the Biosphere 17, no. 1 (1986): 51–57. http://dx.doi.org/10.1007/bf01809812.

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13

Zhang, Qian, Fangying Ji, Lei Jiang, Qiushi Shen, Yuanxiang Mao, and Caocong Liu. "Glycine- and Alanine-Intercalated Layered Double Hydroxides as Highly Efficient Adsorbents for Phosphate with Kinetic Advantages." Nanomaterials 12, no. 4 (2022): 586. http://dx.doi.org/10.3390/nano12040586.

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Phosphate is the main cause of eutrophication. Layered double hydroxides (LDH) are considered to be promising phosphate adsorbents due to their high affinity and large capacity. In this study, we partially intercalated zwitterionic glycine and alanine into Cl-LDH (corresponding to MgAl-LDH with interlayer anion Cl−) and synthesized efficient inorganic–organic nanohybrids for phosphate removal with kinetic advantages. Gly-Cl-LDH, Ala-Cl-LDH and Cl-LDH were characterized, and their phosphate adsorption performances under the influence of environment factors (e.g., solution pH, coexisting anions,

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14

Fox, Allison C., Jason D. Boettger, Eve L. Berger, and Aaron S. Burton. "The Role of the CuCl Active Complex in the Stereoselectivity of the Salt-Induced Peptide Formation Reaction: Insights from Density Functional Theory Calculations." Life 13, no. 9 (2023): 1796. http://dx.doi.org/10.3390/life13091796.

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The salt-induced peptide formation (SIPF) reaction is a prebiotically plausible mechanism for the spontaneous polymerization of amino acids into peptides on early Earth. Experimental investigations of the SIPF reaction have found that in certain conditions, the l enantiomer is more reactive than the d enantiomer, indicating its potential role in the rise of biohomochirality. Previous work hypothesized that the distortion of the CuCl active complex toward a tetrahedral-like structure increases the central chirality on the Cu ion, which amplifies the inherent parity-violating energy differences

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15

Kanu, Kingsley Chukwuemeka, Solomon Nnah Ijioma, and Anthony Chukwubueze Okoboshi. "Biochemical and Histopathological Effects of Acute Exposure to Vinyl Acetate Monomer Vapour in Wistar Rats." Iranian Journal of Toxicology 12, no. 6 (2018): 19–26. http://dx.doi.org/10.32598/ijt.12.6.559.1.

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Background: Vinyl acetate monomer is a commodity chemical widely used in the manufacturing of various products. The chemical is hazardous and exposure to it may occur in both occupational and non-occupational settings. The aim of this study was to characterize the effects of short-term exposure to Vinyl Acetate Monomer (VAM) vapour on the liver and lungs of Wistar rats. Methods: Mice weighing 25-30g were used to determine the acute lethal dose, while Wistar rats weighing 120-140g were randomly assigned to a control group and two experimental groups, which were exposed daily to VAM vapour for 2

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16

Vysotskii, A. L., D. L. Vysotskii, T. A. Gudasheva, R. U. Ostrovskaya, and K. V. Anokhin. "Modulation of long-term memory by delayed administration of the amide of L-pyroglutamyl-D-alanine, a nootropic agent, in spaced and massed training in rats." Neuroscience and Behavioral Physiology 29, no. 2 (1999): 137–42. http://dx.doi.org/10.1007/bf02465317.

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17

Adamski, Michal, та Ariel Kaminski. "Effect of Microcystin-LR, Nodularin, Anatoxin-a, β-N-Methylamino-L-Alanine and Domoic Acid on Antioxidant Properties of Glutathione". Life 12, № 2 (2022): 227. http://dx.doi.org/10.3390/life12020227.

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Cyanobacteria produce a range of toxic secondary metabolites that affect many processes in human, animal and also plant cells. In recent years, some efforts have concentrated on deepening the understanding of their effect on living cells in the context of the disruption of antioxidant systems. Many results suggest that cyanotoxins interfere with glutathione (GSH) metabolism, which often leads to oxidative stress and, in many cases, cell death. Knowledge about the influence of cyanotoxins on enzymes involved in GSH synthesis or during its antioxidant action is relatively broad. However, to date

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18

Akaboshi, Mitsuhiko, Kenichi Kawai та Hirotoshi Maki. "Selective decomposition of either enantiomer of asparatic acid irradiated by60Co-γ-rays in the mixed aqueous solution with D- or L-alanine". Origins of Life and Evolution of the Biosphere 19, № 3-5 (1989): 275–77. http://dx.doi.org/10.1007/bf02388846.

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19

Akaboshi, Mitsuhiko, Kenichi Kawai, Hirotoshi Maki, Wilhelm Ehrlich та Yasuhiro Honda. "Selective decomposition of either enantiomer or aspartic acid irradiated with60Co-γ-rays in the mixed aqueous solution with D- or L-alanine". Origins of Life and Evolution of the Biosphere 20, № 2 (1990): 111–19. http://dx.doi.org/10.1007/bf01808271.

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20

Fox, Stefan, Annika Gspandl, and Franziska M. Wenng. "Acceleration of amino acid racemization by isovaline: possible implications for homochirality and biosignature search." International Journal of Astrobiology 19, no. 3 (2020): 276–82. http://dx.doi.org/10.1017/s1473550420000014.

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AbstractIn nature, abiotically formed amino acids are usually racemic. However, this is not true for the α,α-dialkyl amino acid isovaline (Iva), which has an L-enantiomeric excess in some specimens of carbonaceous meteorites. On the early Earth and Mars, such meteorites were sources of amino acids, including Iva. Therefore, a connection may exist between the possible chiral influence of non-racemic Iva and the origin of biological homochirality. On the surface of a young terrestrial planet, amino acids can be chemically altered in many ways. For example, high temperatures from geothermal heati

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21

Temdie, Romeo Joel Guemmogne, Marc Germain Kuum Minoue, Arnaud Doumogne Djasrane, et al. "Influence of aqueous leafy stem extract of Cochlospermum tinctorium A. Rich. (Cochlospermaceae) on liver injury induced by subacute exposure of rats to carbon tetrachloride." American Journal of Biopharmacy and Pharmaceutical Sciences 2 (August 17, 2022): 7. http://dx.doi.org/10.25259/ajbps_8_2022.

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Objectives: Liver disease is a serious public health problem. There are many causes of liver disease and the liver is a vital organ in the body, so when it is damaged, its function can be affected. Cochlospermum tinctorium is a plant commonly used by Central African populations to relieve liver-related ailments such as jaundice and hepatitis. This study aimed to assess the hepatoprotective activity of aqueous leafy stem extract of C. tinctorium against liver injury induced by subacute exposure of rats to carbon tetrachloride (CCl4). Material and Methods: Thirty rats were distributed into six g

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22

Lee, Eun Jeoung, Yun Kim, Ji Eun Kim, Eileen Laurel Yoon, Sung Ryol Lee, and Dae Won Jun. "ALS-L1023 from Melissa officinalis Alleviates Liver Fibrosis in a Non-Alcoholic Fatty Liver Disease Model." Life 13, no. 1 (2022): 100. http://dx.doi.org/10.3390/life13010100.

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ALS-L1023 is an ingredient extracted from Melissa officinalis L. (Labiatae; lemon balm), which is known as a natural medicine that suppresses angiogenesis. Herein, we aimed to determine whether ALS-L1023 could alleviate liver fibrosis in the non-alcoholic fatty liver disease (NAFLD) model. C57BL/6 wild-type male mice (age, 6 weeks old) were fed a choline-deficient high-fat diet (CDHFD) for 10 weeks to induce NAFLD. For the next 10 weeks, two groups of mice received the test drug along with CDHFD. Two doses (a low dose, 800 mg/kg/day; and a high dose, 1200 mg/kg/day) of ALS-L1023 were selected

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23

Jahangir, Sidrah, Peter John, Attya Bhatti, et al. "LC-MS/MS-Based Serum Protein Profiling for Identification of Candidate Biomarkers in Pakistani Rheumatoid Arthritis Patients." Life 12, no. 3 (2022): 464. http://dx.doi.org/10.3390/life12030464.

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Rheumatoid arthritis is an autoimmune disorder of complex disease etiology. Currently available serological diagnostic markers lack in terms of sensitivity and specificity and thus additional biomarkers are warranted for early disease diagnosis and management. We aimed to screen and compare serum proteome profiles of rheumatoid arthritis serotypes with healthy controls in the Pakistani population for identification of potential disease biomarkers. Serum samples from rheumatoid arthritis patients and healthy controls were enriched for low abundance proteins using ProteoMinerTM columns. Rheumato

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24

Shami, Ashwag, Nada K. Alharbi, Fatimah A. Al-Saeed, et al. "In Silico Subtractive Proteomics and Molecular Docking Approaches for the Identification of Novel Inhibitors against Streptococcus pneumoniae Strain D39." Life 13, no. 5 (2023): 1128. http://dx.doi.org/10.3390/life13051128.

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Streptococcus pneumoniae is a notorious Gram-positive pathogen present asymptomatically in the nasophayrnx of humans. According to the World Health Organization (W.H.O), pneumococcus causes approximately one million deaths yearly. Antibiotic resistance in S. pneumoniae is raising considerable concern around the world. There is an immediate need to address the major issues that have arisen as a result of persistent infections caused by S. pneumoniae. In the present study, subtractive proteomics was used in which the entire proteome of the pathogen consisting of 1947 proteins is effectively decr

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25

Zamora Ramos, C., P. Turiel, N. Garvin Grande, M. Beladiez Giner, M. Alcalde Villar, and A. C. Valenciano. "AB0453 ARE WE DOING A CORRECT METHOTREXATE MONITORING?" Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1416. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2099.

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BackgroundMethotrexate (MTX) is an antimetabolite of folic acid commonly used for the treatment of Rheumatoid Arthritis (RA). Despite its recognized benefit in controlling the activity of the disease, it can cause side effects, such as hepatic and hematologic toxicity. This makes necessary to carry out periodic analytical controls.According to the recommendations of ACR1and EULAR2on the monitoring of MTX toxicity, the most appropriate frequency for analytical controls in patients starting treatment with MTX would be 4-6 weeks, and it could be spaced up to every 3 months when reaching a stable

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26

Edwards, Christopher S., Philip R. Christensen, Greg L. Mehall, et al. "The Emirates Mars Mission (EMM) Emirates Mars InfraRed Spectrometer (EMIRS) Instrument." Space Science Reviews 217, no. 7 (2021). http://dx.doi.org/10.1007/s11214-021-00848-1.

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AbstractThe Emirates Mars Mission Emirates Mars Infrared Spectrometer (EMIRS) will provide remote measurements of the martian surface and lower atmosphere in order to better characterize the geographic and diurnal variability of key constituents (water ice, water vapor, and dust) along with temperature profiles on sub-seasonal timescales. EMIRS is a FTIR spectrometer covering the range from 6.0-100+ μm (1666-100 cm−1) with a spectral sampling as high as 5 cm−1 and a 5.4-mrad IFOV and a 32.5×32.5 mrad FOV. The EMIRS optical path includes a flat 45° pointing mirror to enable one degree of freedo

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