Academic literature on the topic 'L-Met'

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Journal articles on the topic "L-Met"

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Bobrowski, K., and J. Holcman. "Intramolecular three-electron bonds formation in methionyl homopeptides (di-L-Met), (tri-L-Met)." International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 28, no. 5-6 (January 1986): 555. http://dx.doi.org/10.1016/1359-0197(86)90189-x.

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Attia, Youssef A., Fulvia Bovera, Jinquan Wang, Mohammed A. Al-Harthi, and Woo Kyun Kim. "Multiple Amino Acid Supplementations to Low-Protein Diets: Effect on Performance, Carcass Yield, Meat Quality and Nitrogen Excretion of Finishing Broilers under Hot Climate Conditions." Animals 10, no. 6 (June 3, 2020): 973. http://dx.doi.org/10.3390/ani10060973.

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The objective of this study was to evaluate the effect of low-protein diets with amino acid supplementation on growth performance, carcass yield, meat quality and nitrogen excretion of broilers raised under hot climate conditions during the finisher period. In trial 1, broilers from 28 to 49 days of age were fed 18% crude protein (CP) as a positive control or 15% CP supplemented with (1) DL-methionine (Met) + L-lysine (Lys), (2) Met + Lys + L-Arginine (Arg), or (3) Met + Lys + L-Valine (Val). In trial 2, broilers from 30 to 45 days of age, were fed an 18% CP diet as a positive control or 15% CP supplemented with Met, Lys, Arg, Val, L-Isoleucine (Ile) or combination with glycine (Gly) and/or urea as nitrogen sources: (1) Met + Lys, (2) Met + Lys + Arg, (3) Met + Lys + Val, (4) Met + Lys + Ile, (5) Met + Lys + Arg +Val + Ile + Gly, and (6) Met+ Lys + Arg + Val + Ile + Gly + urea. Protein use was improved by feeding low-protein amino acid-supplemented diets as compared to the high-protein diet. Feeding 15% crude protein diet supplemented with only methionine and lysine had no negative effects on carcass yield, CP, total lipids and moisture% of breast meat while decreasing nitrogen excretion by 21%.
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Romanet, Stella, Jörg R. Aschenbach, Robert Pieper, Jürgen Zentek, John K. Htoo, Rose A. Whelan, and Lucia Mastrototaro. "Dietary Supplementation of dl-Methionine Potently Induces Sodium-Dependent l-Methionine Absorption in Porcine Jejunum Ex Vivo." Journal of Nutrition 150, no. 7 (May 2, 2020): 1782–89. http://dx.doi.org/10.1093/jn/nxaa115.

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ABSTRACT Background Methionine is an essential amino acid (AA) with many fundamental roles. Humans often supplement l-Met, whereas dl-Met and dl-2-hydroxy-4-(methylthio)butanoic acid (dl-HMTBA) are more frequently used to supplement livestock. Objectives The study aimed to investigate whether dietary Met source alters the absorptive capacity for Met isomers in the small intestine of piglets. Methods A total of 27 male 10-wk-old piglets in 3 feeding groups received a diet supplemented with 0.21% dl-Met, 0.21% l-Met, or 0.31% dl-HMTBA to meet the Met + cystine requirement. After ≥10 d, absorptive fluxes of d-Met or l-Met were measured at a physiological concentration of 50 μM and a high concentration of 5 mM in duodenum, middle jejunum, and ileum ex vivo. Data were compared by 2-factor ANOVA. Results Across diets, fluxes of both Met isomers at both tested concentrations increased from duodenum to ileum by a factor of ∼2–5.5 (P < 0.05). Pigs supplemented with dl-Met had greater (P < 0.085) absorptive fluxes at 50 μM l-Met (0.50, 2.07, and 3.86 nmol · cm−2 · h−1) and d-Met (0.62, 1.41, and 1.19 nmol · cm−2 · h−1) than did pigs supplemented with dl-HMTBA (l-Met: 0.28, 0.76, and 1.08 nmol · cm−2 · h−1; d-Met: 0.34, 0.58, and 0.64 nmol · cm−2 · h−1) in duodenum, jejunum, and ileum, respectively. Only in jejunum of dl-Met-fed pigs, fluxes at 50 μM l-Met were reduced by the omission of luminal Na+ (from 3.27 to 0.86 nmol · cm−2 · h−1; P < 0.05) and by a cocktail of 22 luminal AAs (to 1.05 nmol · cm−2 · h−1; P < 0.05). Conclusions Dietary supplementation of dl-Met increases the efficiency of l-Met and d-Met absorption at physiologically relevant luminal Met concentrations along the small intestine of pigs, including a very prominent induction of an Na+-dependent transport system with preference for l-Met in the mid-jejunum. Dietary supplementation with dl-Met could be a promising tool to improve the absorption of Met and other AAs.
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Tung, Robert C., and Stephen L. Thornton. "Characteristics of Laboratory Confirmed Ethylene Glycol and Methanol Exposures Reported to a Regional Poison Control Center." Kansas Journal of Medicine 11, no. 3 (January 15, 2019): 67–69. http://dx.doi.org/10.17161/kjm.v11i3.8693.

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Introduction. Ethylene glycol (EG) and methanol (MET) exposuresare rare but can cause significant morbidity and mortality.Though frequently treated similarly, EG and MET exposures havecharacteristics that are not well differentiated in the literature. Wesought to describe the clinical characteristics of EG and MET exposures,confirmed with quantitative serum levels. Methods. An IRB-approved retrospective review of the Universityof Kansas Health System Poison Control Center database from July2005 to July 2015 identified all EG/MET exposures evaluated ata health care facility. Initial measurements were EG/MET levels,serum pH, serum creatinine, anion gap, serum ethanol level, maxanion gap, max osmolar gap, therapy performed (hemodialysis,fomepizole, ethanol) and death. Results. The search identified 75 cases, with 59 cases having onlydetectable EG levels and 15 cases having only detectable MET levels.The average EG level was 126 mg/dL (range 5 - 834). The averagedetectable methanol level was 78 mg/dL (range 5 - 396). The averagemaximum anion gap of the EG positive group was 20 mEq/L (range8 - 35). The average maximum anion gap of the MET positive groupwas 14 mEq/L (range 6 - 34). One death was reported in the EG positivegroup, with an initial level of 266 mg/dL. Conclusions. In this study of EG/MET exposures, EG exposureswere more common than MET exposures, but they had similardemographics, laboratory findings, and interventions. Continuedstudies are warranted to characterize these uncommon exposuresfurther. Kans J Med 2018;11(3):67-69.
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Hlaváček, Jan, Jana Pírková, Miroslava Žertová, Jan Pospíšek, Lenka Maletínská, and Jiřina Slaninová. "Cholecystokinin Heptapeptide Analogues with Multiple Modification in Peptide Chain." Collection of Czechoslovak Chemical Communications 58, no. 11 (1993): 2761–65. http://dx.doi.org/10.1135/cccc19932761.

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Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr(SO3-Na+)-Met-Gly-Trp-Met-Asp-Phe-NH2) Ia and its seven analogues Ib - Ih. In the analogues Ib and Ic the Met residue in the carboxyterminal part of the molecule was substituted for L- or D-Phe Me3. In the analogues Id and Ie with Phe residue substituted by L- or D-Phe Me3 the Neo was inserted in the place of this Met residue and in the analogues If and Ig, an addition to PheMe3 substitution in the carboxyterminus, both Met residues were replaced for Neo. This dual substitution for Met residues was also applied in the analogue Ih with coded Phe residue in the C-terminus.
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Rasch, Ilka, Solvig Görs, Armin Tuchscherer, John K. Htoo, Björn Kuhla, and Cornelia C. Metges. "Substitution of Dietary Sulfur Amino Acids by DL-2-hydroxy-4-Methylthiobutyric Acid Increases Remethylation and Decreases Transsulfuration in Weaned Piglets." Journal of Nutrition 149, no. 3 (February 15, 2019): 432–40. http://dx.doi.org/10.1093/jn/nxy296.

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ABSTRACT Background DL-2-hydroxy-4-methylthiobutyric acid (DL-HMTBA), an L-methionine (L-Met) hydroxyl analogue, has been suggested to be a dietary L-Met source. How dietary DL-HMTBA compared with L-Met affects whole-body L-Met kinetics in growing individuals is unknown. Objectives We determined to what extent DL-HMTBA supplementation of an L-Met–deficient diet affects whole-body L-Met and L-cysteine (L-Cys) kinetics, protein synthesis (PS), and the L-Met incorporation rate in liver protein (L-MetInc) compared with L-Met and DL-Met supplementation in a piglet model. Methods Forty-five, 28-d-old weaned piglets (male, German Landrace) were allocated to 4 dietary groups: L-Met-deficient diet [Control: 69% of recommended L-Met plus L-Cys supply; 0.22% standardized ileal digestible (SID) L-Met; 0.27% SID L-Cys; n = 12] and Control diet supplemented equimolarly to 100% of recommended intake with either L-Met (n = 12; LMET), DL-Met (n = 11; DLMET), or DL-HMTBA (n = 10; DLHMTBA). At 47 d of age, the piglets were infused with L-[1-13C; methyl-2H3]-Met and [3,3-2H2]-Cys to determine the kinetics and PS rates. Plasma amino acid (AA) concentrations, hepatic mRNA abundances of L-Met cycle and transsulfuration (TS) enzymes, and L-MetInc were measured. Results During feed deprivation, L-Met kinetics did not differ between groups, and were ≤3 times higher in the fed state (P < 0.01). Remethylation (RM) was 31% and 45% higher in DLHMTBA than in DLMET and Control pigs, respectively, and the RM:transmethylation (TM) ratio was 50% higher in DLHMTBA than in LMET (P < 0.05). Furthermore, TS and the TS:TM ratio were 32% lower in DLHMTBA than in LMET (P < 0.05). L-MetInc was 42% lower in DLMET and DLHMTBA than in L-Met-deficient Control pigs, whereas plasma AA and hepatic mRNA abundances were similar among DL-HMTBA–, L-Met–, and DL-Met–supplemented pigs. Conclusions In piglets, DL-HMTBA compared with L-Met and DL-Met supplementation increases RM and reduces the TS rate to conserve L-Met, but all 3 Met isomers support growth at a comparable rate.
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Ullrich, Cristina, Marion Langeheine, Ralph Brehm, Venja Taube, Mercedes Rosillo Galera, Karl Rohn, Johanna Popp, and Christian Visscher. "Influence of Different Methionine Sources on Performance and Slaughter Characteristics of Broilers." Animals 9, no. 11 (November 19, 2019): 984. http://dx.doi.org/10.3390/ani9110984.

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Sustainably produced poultry meat with consideration of animal health poses a challenge for broiler production. Low protein diets with high amounts of synthetic amino acids (AAs) like methionine (Met) are the consequence. In a five-week feeding trial, 360 broilers (Ross 308) assigned to four feeding groups were offered protein-reduced complete diets (starter: 20% crude protein (CP); grower: 18.5% CP; finisher: 17.5% CP), supplemented with essential AAs. The “MHA” group received DL-2-hydroxy-4-(methylthio) butanoic acid (DL-HMTBA; trade name: MHA®), groups “L” and “DL” the respective Met source in equivalent concentrations each exceeding the nutritional recommendations. “R-MHA” (“R” for “reduced”) received the minimum required level (using MHA as Met source). Performance exceeded performance goals without differences between the groups. The average feed conversion ratio (FCR) amounted to 1.35. The carcass/body weight ratio of R-MHA was significantly lower (0.782) compared to DL (0.808) and L (0.809). Breast meat of R-MHA contained significantly more fat (144 g/kg dry matter (DM)) compared to L (104 g/kg DM) and significantly lower CP content (R-MHA: 838 g/kg DM; L: 875 g/kg DM). The results indicated possible improvement in slaughter yield by protein-reduced diets supplemented with L-Met, thus recommending further research focusing on the Met influence.
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Dupuis, Liliane, C. Linda Saunderson, Antoine Puigserver, and Patrick Brachet. "Oxidation of methionine and 2-hydroxy 4-methylthiobutanoic acid stereoisomers in chicken tissues." British Journal of Nutrition 62, no. 1 (July 1989): 63–75. http://dx.doi.org/10.1079/bjn19890008.

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Oxidation of dl-2-hydroxy 4-methylthiobutanoic acid (dl-HMB), dl-methionine (dl-MET) and l-methionine (l-MET) in chicken tissue homogenates was compared using 1-14C-labelled tracers. The pattern of oxidation of the substrates was similar at both low (0.7 mm) and high (20 mm) concentrations. The rate of conversion to 2-keto 4-methylthiobutanoic acid (KMB) was highest for dl-MET and lowest for l-MET in kidney, liver and intestinal mucosa. In breast muscle, rates for dl-MET and l-MET were similar at 0.7 mm, but dl-HMB showed the highest rate at 20 mm. Kidney contained the highest specific activity for oxidation of all three substrates. Raising the pH of liver and kidney homogenates from 7.5 to 8.6 increased the oxidation of dl-MET, exclusively. Experiments with inhibitors of D-2-hydroxy acid dehydrogenase (EC 1.1.99.6) and L-2-hydroxy acid oxidase (EC 1.1.3.15) suggested that d- and l-HMB were stereospecifically oxidized by the enzymes. KMB stimulated l-MET oxidation in kidney yet inhibited l-MET oxidation in liver homogenates. The effect of KMB on dl-MET and dl-HMB oxidation also varied between tissues. Amino-oxyacetate inhibited l-MET oxidation completely and dl-MET and dl-HMB oxidation almost completely in both kidney and liver. L-Cycloserine was less potent than amino-oxyacetate and decreased l-MET oxidation more in kidney than in liver. It can be calculated from the results that, at low substrate concentrations, the liver contributes principally to the whole body oxidation of both dl-HMB and dl-MET. At high (greater than physiological) concentrations, dl-HMB would be oxidized principally in skeletal muscle. At all concentrations, l-MET would be converted to KMB mainly in the muscle.
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Selimović, Enisa, Biljana Petrović, Dragan Čcanović, Živadin D. Bugarčić, and Jovana Bogojeski. "Kinetic Studies on the Reactions of [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+ Complexes with Some Thiols and Thioethers." Australian Journal of Chemistry 66, no. 5 (2013): 534. http://dx.doi.org/10.1071/ch12218.

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Substitution reactions of the complexes [(TLtBu)PtCl]+ and [Pt(tpdm)Cl]+, where TLtBu = 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and tpdm = terpyridinedimethane, with nucleophiles: S-methyl-L-cysteine (S-Met-L-Cys), L-cysteine (L-Cys), glutathione (GSH) and L-methionine (L-Met) were studied in aqueous 0.1 M NaClO4 solution in the presence of 10 mM NaCl using variable-temperature UV-vis spectrophotometry. The higher reactivity of the complex with the tpdm ligand could be attributed to the influence of the bulkiness of the tert-butyl-groups from the [(TLtBu)PtCl]+ complex. The order of reactivity of the studied ligands is: S-Met-L-Cys > L-Met > GSH > L-Cys. The thioethers (S-Met-L-Cys and L-Met) are more reactive than the thiols (GSH and L-Cys). This order of reactivity is in relation with their electron properties and structures. The negative values reported for the entropy of activation confirmed the associative mode.
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Storch, K. J., D. A. Wagner, J. F. Burke, and V. R. Young. "[1-13C; methyl-2H3]methionine kinetics in humans: methionine conservation and cystine sparing." American Journal of Physiology-Endocrinology and Metabolism 258, no. 5 (May 1, 1990): E790—E798. http://dx.doi.org/10.1152/ajpendo.1990.258.5.e790.

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Methionine (Met) conservation in healthy young adult men (4/diet group) was explored by supplying one of the following three L-amino acid based diets: 1) adequate Met but no cystine; 2) neither Met nor cystine; or 3) no Met but cystine supplementation. After 5 days, subjects received a continuous intravenous infusion of L-[1-13C; methyl-2H3]Met for 5 h while the diet was given as small isocaloric isonitrogenous meals. Estimates were made of rates of Met incorporation into protein synthesis (S) and release from body proteins (B), transmethylation (TM), remethylation of homocysteine (RM), and transsulfuration (TS). For the adequate Met diet, the rates were S = 24 +/- 2, B = 18 +/- 1, TM = 12.4 +/- 1.7, RM = 4.7 +/- 1.1, and TS = 7.6 +/- 0.6 (SE) mumol.kg-1.h-1. The sulfur amino acid-devoid diet significantly (P less than 0.05) reduced S, TM, RM, and TS. Supplementation of this diet with cystine reduced Met oxidation (P = 0.05). Therefore, two loci are quantitatively important regulatory points in Met conservation in vivo: 1) the distribution of Met between the pathways of protein anabolism and TM (Met locus) and 2) the distribution of homocysteine between RM and TS (homocysteine locus).
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Dissertations / Theses on the topic "L-Met"

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Zhang, Shuai. "Physiological and Biochemical Aspects of Methionine Isomers and Precursors in Broilers." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71816.

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Methionine (Met) is an essential amino acid for animals and also the first limiting amino acid in a broiler diet. The dietary supplemental Met sources include the natural isoform L-methionine (L-Met), the synthetic form DL-methionine (DL-Met) and the synthetic Met precursor DL-2-hydroxy-4 (methylthio)-butanoic acid (DL-HMTBA). The objective of this dissertation was to determine the effect of different dietary Met source supplementation and Met deficiency on a series of physiological and biochemical aspects, including growth performance, global DNA methylation and methyltransferase activity, blood antioxidant profile (e.g., acute phase protein, leukocyte count), intestinal nutrient transporter gene expression, Met converting enzyme gene expression and activity, oxidative stress markers, and a potential pathway related to amino acid signaling. To achieve this goal, male Cobb-500 broilers were raised from day of hatch (d0) to d35 post-hatch and fed a diet deficient in methionine and cysteine (Met + Cys) (control) or the same diet supplemented with 0.22% DL-Met, 0.22% L-Met or 0.31% DL-HMTBA (to provide 0.22% DL-Met equivalent) to meet Met + Cys requirements. Tissues (liver, breast muscle, duodenum, jejunum and ileum) and blood samples were collected at various ages from d0 to d35 for analysis. Met supplementation significantly improved body weight gain and feed efficiency compared to the Met deficient group, but no differences were observed among DL-Met, L-Met and DL-HMTBA for growth performance parameters (P > 0.05). Met supplementation had no effect on red blood cell packed cell volume, white blood cell differential count, hepatic total DNA methylation, DNA methyltransferase and Met oxidase activity, and had limited effects on activation of p70S6K, a key amino acid signaling protein (P > 0.05). Although dietary Met sources did not change oxidative status of the treated chickens, both L-Met and DL-Met but not DL-HMTBA supplementation decreased the level of acute phase protein serum amyloid A compared to the control group (P > 0.05). The effect of Met supplementation on gene expression of nutrient transporters and Met converting enzymes were complex and dynamic. Most of the target genes demonstrated tissue- and development-dependent expression patterns, with few significant treatment effects observed. L-Met and DL-Met but not DL-HMTBA supplementation enhanced the neutral amino acid transporters ATB0,+ and B0AT gene expression in various small intestinal segments. All three Met sources increased monocarboxylic acid transporter (MCT1) gene expression in the jejunum. DL-HMTBA and L-Met fed chickens showed greater hepatic L-HMTBA oxidase (HAO1) gene expression. DL-Met increased glutamic-oxaloacetic transaminase 2 (GOT2) gene expression in the duodenum. An in vitro study with tissue explants, however, did not demonstrate a similar gene expression pattern as that in the in vivo study. Lastly, RNA sequencing results illustrated that Met deficiency could lead to many differentially expressed genes but different supplemental Met sources had no influence on hepatic gene expression profiles. In conclusion, as common dietary supplemental Met sources, L-Met, DL-Met and DL-HMTBA exhibited similarity in impacting intestinal amino acid/peptide/monocarboxylic acid transporter gene expression and Met converting enzyme activity. The regulatory roles of Met as an antioxidant and nutrient signaling in cell metabolism were not affected by different dietary supplemental Met sources.
Ph. D.
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Lima, Analwik Tatielle Pereira de. "Alimento como met?fora, met?fora como alimento : a arte de nutrir uma educa??o complexa." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/14301.

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Cette narrative fait le parcours d une recherche et de ses reflexions ici annonc? comme une odiss?e gastronomique et une g?ografie gourmante , dont les elements interpretatifs rendent possible concevoir qu une lecture de la m?taphore et de la st?thique alimentaire puissent contribuer pour penser une ?ducation sensible, complexe, une education guid?e par une experimentation esth?tique de la condition humaine, qui provoque les sens, qui permettent ?voquer et r?cuperer les connaissances et les savoirs pertinents, et qui confirme l indissociabilit? du sujet dans ses plusieurs poles : nature et culture, ?motion et raison. Comme contribution epist?mologique, la dissertation, cherche ?tendre la compr?hension d ?tudes qui abordent le Corp, l Aliment, la M?taphore, l Esth?tique et l ?ducation, en d?clanchant des relations entre les espaces acad?micien et cotidien, en exp?rimentant d autres formes de sentir, penser et d ?tre dans le monde. Pouss?e par une raison gourmande, et comme dans un rituel de pr?paration d aliment, j opte par les r?lations transversales des savoirs ; je construis un dialogue entre les auteurs de domaine de connaissances multiples, comme la Filosophie, l Antropologie, l ?tologie et l ?ducation, en travaillant une reconstruction de concepts. Pour la t?che de cette odiss?e gastronomique, je d?couvre l approche entre un programme, comme m?thode, et un livre de recettes culinaires herm?tiques. J ai choisi de construir des estrat?gies m?todologiques qui indiquent les chemins sur les quelles l imagination, la cr?ativit? et la r?invention, non seulement puissent mais doivent servir comme des ?piceries qui empr?gne d odeurs, de saveurs et de couleurs la connaissance, sans laisser de c?t? la rigueur, principe in?gociable dans une science ouverte. J ai choisi, pour m accompagner dans cet ?tude, des sages, des scientistes et des po?tes, entre eux je fais remarquer Michel Onfray, Boris Cyrulnik, Merleau-Ponty, Edgar Morin e Concei??o Almeida. Avec eux, j ai d?ssin? des cartes, go?t? des g?ographies, des terres, des ciels. J ai fr?quenter des histoires et des personnages concrets et imaginaires; j ai convoqu? des souvenirs acumul?s pendant l enfance, avec ses trames, ses textures, ses saveurs, ses parfuns, ses couleurs, ses images, ses gestes, ses mots et ses silences, o? le corp devient un m?diateur d acc?s ? la connaissance. Comme artifice compl?mentaire pour suivre la route, je parie sur le rapport fondamental entre le corp, l aliment, la m?taphore, l esth?tique et l ?ducation, je m utilise du Cin?ma, en cherchant d apprendre dans cet art, une ?xistentialit? humaine par le rapport entre la vie, l aliment et les personnages. Finalement, je reaffirme l importance de nourir des affections par une formation et une mani?re de penser capables de conect? des connaissances d univers dinstingu?s, et qui contribuent pour une conscience de la condition humaine et l apprentissage d une ?ducation de la vie et pour la vie
Esta narrativa descreve o percurso de uma pesquisa e as reflex?es dela decorrentes aqui anunciadas como uma odiss?ia gastron?mica e uma geografia gulosa , cujos elementos interpretativos tornem poss?vel conceber que uma leitura da met?fora e da est?tica alimentar possam contribuir para se pensar uma educa??o sens?vel, complexa, uma educa??o guiada por uma experimenta??o est?tica da condi??o humana, que aciona os sentidos, permitindo evocar e rememorar conhecimentos e saberes pertinentes, e que reitera a indissociabilidade do sujeito em seus v?rios p?los constituintes: natureza e cultura, emo??o e raz?o. Como contribui??o epistemol?gica, a disserta??o, busca ampliar a compreens?o de estudos que abordam o Corpo, o Alimento, a Met?fora, a Est?tica e a Educa??o, acionando inter-rela??es, entre os espa?os acad?mico e cotidiano, experimentando outras formas de sentir, pensar e estar no mundo. Impulsionada por uma raz?o gulosa, e como num ritual de prepara??o do alimento, escolho transversalizar saberes; construo um di?logo entre autores de ?reas de conhecimentos m?ltiplos, como a Filosofia, a Antropologia, a Etologia e a Educa??o, operando uma ressignifica??o de conceitos. Para a empreitada dessa odiss?ia gastron?mica, descubro a aproxima??o entre um programa enquanto m?todo e um livro de receitas culin?rias herm?ticas. Optei por construir estrat?gias metodol?gicas que indicassem caminhos nos quais a imagina??o, a criatividade e a reinven??o possam e devam servir como especiarias, impregnando de odores, sabores e cores o conhecimento, sem abrir m?o do rigor, princ?pio inegoci?vel a uma ci?ncia aberta. Escolhi para me acompanhar s?bios, cientistas e poetas, entre os quais destaco Michel Onfray, Boris Cyrulnik, Merleau-Ponty, Edgar Morin e Concei??o Almeida. Com eles, desenhei mapas, provei geografias, terras, c?us. Convivi com hist?rias e personagens concretos e imagin?rios; convoquei lembran?as acumuladas na inf?ncia, com suas tramas, texturas, sabores, aromas, cores, imagens, gestos, palavras e sil?ncios, em que o corpo torna-se um mediador de acesso ao conhecimento. Como artif?cio complementar para prosseguir viagem, apostando na rela??o fundamental entre corpo, alimento, met?fora, est?tica e educa??o, recorro ao cinema, buscando apreender nessa arte uma existencialidade humana por meio da rela??o entre vida, alimento e personagens. Por fim, reafirmo a import?ncia de nutrir afetos atrav?s de uma forma??o e de um modo de pensar capazes de solidarizar conhecimentos separados, e que contribuam para uma consci?ncia da condi??o humana e para o aprendizado de uma educa??o da vida e para a vida
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Schenker, Teresa [Verfasser], Konrad L. [Akademischer Betreuer] Streetz, and Christoph [Akademischer Betreuer] Wruck. "Die Expression von MET im Rahmen chronischer Lebererkrankungen / Teresa Schenker ; Konrad L. Streetz, Christoph Wruck." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/117181853X/34.

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Stöber, Barbara. "Charakterisierung des Transportes der Aminosäuren L-[Methyl-3H]-Methionin (Met) und O-(2-[18F]fluorethyl)-L-Tyrosin (FET) in humane Lymphozyten, Makrophagen und Kolonkarzinomzellen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973390352.

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Backes, Karin Lilian Hagemann. "Mar de poeta : a met?fora do oceano nas l?ricas de Cec?lia Meireles e Sophia Andresen." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2009. http://tede2.pucrs.br/tede2/handle/tede/1914.

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Nosso objetivo ? analisar o oceano como met?fora nas l?ricas de Cec?lia Meireles (1901-1964) e Sophia Breyner Andresen (1919-2004), a partir do texto do fil?sofo Paul Ricoeur, A met?fora viva. A proposta de Ricoeur ? demonstrar que a compet?ncia metaf?rica est? incompleta sem o apoio psicol?gico da imagina??o e do sentimento, em que a imagem ? tomada como o ?ltimo momento de uma teoria sem?ntica. Sua teoria da compet?ncia metaf?rica ser? utilizada para comprovar como cada poeta emprega essa figura de linguagem para atingir determinados prop?sitos em suas l?ricas, com base em influ?ncias comuns. Cec?lia est? orientada na dire??o do m?stico e busca a transcend?ncia, enquanto Sophia, por conta da cultura grega de raiz cl?ssica, ? m?tica e imanente. As met?foras do mar, nas duas obras, se prestam como um meio po?tico privilegiado desses posicionamentos.
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Bicicgo, Cleber. "Ler o pol?tico no modo como se l? as met?foras de leitura no discurso da cr?tica liter?ria." Universidade Federal da Fronteira Sul, 2014. https://localhost:443/handle/prefix/90.

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A partir do conceito de met?fora e da no??o de efeito metaf?rico fundamentados no trabalho do franc?s Michel P?cheux, esta disserta??o prop?e analisar as met?foras de leitura no discurso da Cr?tica Liter?ria, para compreender o funcionamento do pol?tico-ideol?gico no discurso metaf?rico. A disputa ideol?gica na produ??o do conhecimento, segundo P?cheux, est? na materialidade das met?foras que uma ci?ncia usa para ?compreender e se fazer compreender?. Questionando, ent?o, as met?foras de leitura, como est?o formuladas no discurso da Cr?tica Liter?ria, o presente estudo leva a considerar que a constitui??o hist?rico-discursiva das met?foras n?o possui uma origem, e sim diferentes formas de funcionamento, conjunturalmente tomadas pela disputa entre diferentes concep??es de leitura. A partir desse entendimento, surgem duas considera??es: a primeira ? que n?o existe uma mem?ria homog?nea que estaria na ?origem? da met?fora; a segunda ? que a met?fora ? produzida conforme o contexto de produ??o, podendo se deslocar para dentro de diferentes forma??es discursivas. O funcionamento do discurso metaf?rico marca um posicionamento pol?tico-ideol?gico, cujo resultado aponta para a rela??o entre uma pr?tica cient?fica e uma pr?tica pol?tica, materializadas nas met?foras de leitura. Trata-se, dessa maneira, de um estudo que problematiza o discurso metaf?rico a partir do posicionamento pol?tico-ideol?gico que o sujeito cr?tico liter?rio assume ao interpretar. Esta pesquisa traz uma contribui??o importante para os estudos sobre a met?fora, na perspectiva da An?lise de Discurso, al?m de subsidiar a pr?pria Cr?tica Liter?ria, na compreens?o do processo hist?rico que marca as met?foras que ela usa para compreender o funcionamento dos sentidos numa obra liter?ria.
From the concept of metaphor and metaphorical effect?snotion based on Michel P?cheux?swork, this dissertation proposes to examine the metaphors of reading on the discourse of literary criticism to understand the functioning of the political-ideological discourse in metaphorical discourse. The ideological struggle in the production of knowledge, according to P?cheux, is the materiality of metaphor that a science uses ?to understand and be understood?.So, questioning the metaphors of reading, as they are formulated in the discourse of literary criticism, this study leads to the conclusion that historical and discursive constitution of metaphors does not have a source, but different ways of working, conjuncturally taken by the dispute between different conceptions of reading. Based on this understanding, two considerations arise: the first is that there is no homogeneous memory that would be the ?origin? of metaphor; the second is that the metaphor is produced according to the context of production and can move within different discursive formations. The functioning of metaphoric discourse marks a political-ideological stance which the results points to the relationship between scientific practice and political practice, embodied in the metaphors of reading. It is, thus, a study that discusses the metaphoric discourse from the political-ideological stance that the literary critic subject assumes when he interprets. This research makes an important contribution to studies on metaphor, from the perspective of discourse analysis, in addition to supporting the literary criticism itself on understanding the historical process that marks the metaphors it uses to understand the functioning of the senses in a literary work.
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Zimmer, Stephan. "Charged Higgs Boson Studies in the Channel pp→a1h±→4b+l+MET in the Next-to MSSM (NMSSM) with the ATLAS Experiment." Thesis, Uppsala universitet, Högenergifysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119324.

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Next-to-minimal super-symmetric extensions of the Standard Model (SM) predict the existence of several non-SM like Higgs bosons. The process pp→a1h±→4b+W involves the production and the decay of a spin-0 charged Higgs boson and a CP-odd Higgs boson a1 which can have a sizable cross section in the NMSSM. The invariant masses of these intermediate bosons can be reconstructed from the four momenta of the final state particles using mass minimization algorithms. This thesis presents a cut-based analysis of two mass scenarios and specialized algorithms that are capable of recovering the signal in a large background arising from Standard Model processes such as ttbar. The analysis is tested with a realistic ATLAS detector simulation investigating trigger efficiencies and probing several jet reconstruction algorithms.
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Berger, Evelin [Verfasser], and Lothar [Akademischer Betreuer] Jänsch. "Time-resolved characterization of the HGF/Met response and the influence of L. monocytogenes InlB on the physiological phosphoproteome / Evelin Berger ; Betreuer: Lothar Jänsch." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175822671/34.

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Truter, Leani. "Obesiteit se verband met motoriese en fisieke ontwikkeling en die effek van 'n multidissiplinêre fisieke aktiwiteitsintervensie daarop by 10– tot 12–jarige kinders / Truter L." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7300.

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The increasing prevalence of childhood obesity worldwide is viewed as a global epidemic (World Health Organization, 2010). It is associated with a variety of health problems as well as physical– (cardio–respiratory endurance, flexibility, muscular strength, muscular endurance, and body composition), and motor proficiency (fine manual control, manual coordination, body coordination, and strength–and–agility) (Asayama et al., 2003:644; Okely et al., 2004:242; Tokmakidis et al., 2006:870). As far as the South African context is concerned, there is little research examining these relationships and the effect of physical intervention there upon, in nine– to 12–year old children. The first and second objectives of this study were to determine whether obesity would influence the physical– and/or the motor proficiency of nine– to 12–year–old South African children. The third and fourth objectives of this study were to determine the effect of a multidisciplinary intervention on the physical– and the motor proficiency of nine– to 12–year–old obese children. For objectives one and two, a cross–sectional study was performed on 280 children (128 boys and 152 girls), with an average age of 10.6 years (±1.05). Anthropometric–, physical– and motor measurements were obtained by the 'Fitnessgram' (Meredith & Welk, 1999) and the 'Bruininks–Oseretsky Test of Motor Proficiency–II' (Bruininks & Bruininks, 2005). Body mass index (BMI) cut–off points were used to classify the children as normal, overweight, or obese (Cole et al., 2000). The data was analysed with regard to the above–mentioned objectives with the Statistica computer program, by means of descriptive statistics, Spearman rank correlations, and variance analyses. The results show that the physical fitness variables, cardio–respiratory endurance and muscular strength, particularly leg muscular strength, showed significant decreases with an increase in BMI. A progressive, but insignificant, decrease was found in muscular endurance with an increase in BMI, while flexibility showed the weakest relationship to BMI. The motor variables strength–and–agility weakened significantly with an increase in BMI, while fine manual control, manual coordination, and body coordination showed the weakest relationships to BMI. Variance analysis showed further significant relationships among BMI, cardio–respiratory endurance, muscular strength, and running speed–and–agility (p<0.05). It can be concluded that health–promoting physical fitness and the motor proficiency of young South African children are negatively influenced by obesity and intervention strategies are recommended to promote the quality of life of such children. For objectives three and four, an availability random sample of 37 experimental subjects, with an average age of 11 years (±0.99) was taken, where 20 subjects (seven boys and 13 girls) took part in a multidisciplinary intervention programme, and 17 subjects (six boys and 11 girls) formed part of a control group. Body composition, physical–, and motor proficiency were analysed by the 'Fitnessgram' (Meredith & Welk, 1999) and the 'Bruininks–Oseretsky Test of Motor Proficiency–II' (Bruininks & Bruininks, 2005) during baseline measurements, on completion of the intervention programme, and after a follow–up period of three months. The results, which were analysed with a repeated–measures analysis, Bonferroni–post–hoc analysis, and dependent and independent t–tests, show that the intervention programme brought about a significant change in all the body composition variables, excluding body height. Flexibility, muscular strength, and abdominal muscular endurance, as well as one of the four fine manual control test items (folding paper), two of the 12 body coordination test items (tapping feet and fingers - opposite sides synchronised, and standing on one leg on a line - eyes closed), and six of the seven strength and agility test items (shuttle run, stepping sideways over a balance beam, one–legged stationary hops, one–legged side hops, two–legged side hops, and sit–ups), showed significant differences from the control group on completion of the intervention programme. The results indicate that the intervention brought about differences in body composition and physical– and motor proficiency and also showed a sustainable effect over a period of three months on body fat percentage, subscapular skinfold and leg muscular strength. From this, it can be deduced that young obese children need sustained guidance to be able to maintain the lifestyle adaptations that are required by obesity interventions. It can be concluded that the physical– and motor proficiency of children is negatively influenced by obesity, that a multidisciplinary intervention programme improves the body composition profile of obese children and has a positive effect on the physical– and the motor proficiency of obese nine– to 12–year old South African children, although the effect is not sustainable without ongoing, controlled intervention.
Thesis (Ph.D. (Kinderkinetics))--North-West University, Potchefstroom Campus, 2012.
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Oliveira, Alzir. "O latim, uma l?ngua morta?: uma met?fora em an?lise: o olhar da ling??stica aplicada e suas implica??es para o ensino." Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16286.

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The focus of this research is the teaching of the Latin language. Due to the fact that its teaching has been facing a growing crisis in the last four decades, which currently persists, we ponder about external and internal causes of its decline, aiming at pointing out an alternative that enable us to find a way out of this situation. So, our research questions mainly concern how the teaching of Latin is viewed amongst the academic society, also investigating if it has kept up with the development of the scientific reflection about human language and the new approaches on language teaching. Furthermore, we analyse the contribution that the study of Latin can provide to the academic formation of language teachers and try to identify the areas of knowledge that can contribute to a reshaping of its teaching. Based on these guidelines, we have established as the goals of this research: 1) to reflect about the current situation of the teaching of Latin and the causes of its decline; 2) to determine its social representation among teachers and students of the Language Courses, as a way of defining the role it fulfills in the academic formation of teachers; 3) to accomplish an exploratory study of some handbooks that show alternative proposals on how to teach Latin, in order to detect their adequacy to current times and to the goals of the academic study of languages; 4) to offer an alternative proposal on how to teach Latin that takes into account the principles of Applied Linguistics, considering the socio-historical and cultural aspects of the language, enabling it to meet the requirements set by modern times. This research is divided into two parts. The first part presents the theoretical framework. We map the studies about Latin teaching inside and outside Brazil and argue against the concept of Latin being a dead language, presenting arguments set on changing this view. Then we describe and comment the notions of literacy, genre and culture, which helped us understand the reasons for the decline of the teaching of Latin and to point out suitable ways to overcome the crisis. The second part is dedicated to reflecting on the literacy practices in Latin teaching. We began by examining the answers to the questionnaires given to students and teachers about the view of Latin in the Language Courses; then we reflect on the teaching-learning of Latin as an academic literacy practice followed by an analysis of the didactic material used in teaching Latin. Finally, we suggest an approach of the familiar letter genre in ancient Rome as a means of teaching Latin in a contextualized way
O foco deste trabalho ? o ensino da l?ngua latina. Partindo da constata??o de que esse ensino vem enfrentando, desde as ?ltimas quatro d?cadas, uma situa??o crescente de crise, que perdura nos dias atuais, refletimos sobre as causas externas e internas do seu decl?nio, com o objetivo de apontar alguma alternativa para a sa?da da crise em que se encontra. Assim, nossas quest?es de pesquisa se preocupam, antes de mais nada, em verificar como o ensino do latim ? visto no meio acad?mico, investigando ainda se este ensino tem acompanhado os progressos da reflex?o cient?fica sobre o fen?meno da linguagem humana e sobre as novas abordagens do ensino de l?nguas. Al?m disso, discutimos acerca da contribui??o que o estudo do latim pode oferecer para a forma??o acad?mica em Letras e procuramos identificar os campos do saber que podem contribuir para um redimensionamento do seu ensino. Em raz?o dessas quest?es, estabelecemos como objetivos do trabalho 1) Refletir sobre a situa??o atual do ensino do latim e sobre as causas do seu decl?nio; 2) Identificar sua representa??o social no meio acad?mico discente e docente do Curso de Letras, como forma de contribuir para a defini??o do papel que lhe cabe na forma??o docente; 3) Fazer um estudo explorat?rio de alguns comp?ndios que apresentam propostas alternativas de didatiza??o do latim, com o intento de verificar sua adequa??o ? nossa realidade e aos objetivos da forma??o em Letras; 4) Apresentar uma proposta alternativa de ensino do latim que leve em conta as contribui??es da Ling??stica Aplicada e que, contemplando os aspectos s?cio-hist?ricos e culturais da l?ngua, seja capaz de atender as exig?ncias da modernidade e da sua inser??o no curr?culo de Letras. O trabalho est? dividido em duas partes. A primeira constitui o quadro te?rico. Nela procedemos a um mapeamento introdut?rio dos estudos sobre o ensino do latim no Brasil, com uma breve incurs?o no panorama europeu e norte americano. Em seguida, tecemos considera??es sobre a concep??o do latim como l?ngua morta, apresentando argumentos para uma revis?o desta met?fora. Finalizamos com a apresenta??o dos conceitos de letramento, g?nero e cultura, que fundamentam teoricamente a nossa proposta de abordagem do ensino do latim. A segunda parte ? destinada ? reflex?o sobre as pr?ticas de letramento no ensino do latim. Come?amos examinando as respostas aos question?rios aplicados a alunos e professores, com o intuito de detectar as representa??es acerca do latim no meio acad?mico de Letras, refletimos sobre o ensino-aprendizagem do latim como uma pr?tica de letramento acad?mico, detendo-nos a seguir na an?lise de materiais utilizados para a didatiza??o do latim. Por fim, sugerimos uma abordagem do g?nero carta familiar em Roma como instrumento de ensino do latim de uma forma contextualizada
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Books on the topic "L-Met"

1

Met groter L: Van Couperus tot Claus. Leuven: Davidsfonds/Clauwaert, 1994.

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Hirt, Manfred A. Construction me tallique: Notions fondamentales et me thodes de dimensionnement. Lausanne: Presses Polytechniques et Universitaires Romandes, 2006.

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Attention deficit hyperactivity disorder in adulthood: A practitioner's handbook. Philadelphia, PA: Brunner/Mazel, 1999.

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Zammit, Raymond G. Meta jibki l-korp. Malta: Zammit, 2004.

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L' étoile de mer. Monaco: Editions du Rocher, 1986.

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Mathieu, Jean Luc. L' Outre-Mer français. Paris: Presses universitaires de France, 1994.

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Fieschi, Jacques. L' homme à la mer. Paris: J.C. Lattès, 1990.

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Mollat, Michel. L' Europe et la mer. Paris: Seuil, 1993.

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Krist. L' arbre de mes fruits. [Québec]: Editions Marie-Lune, 1995.

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Leconte, Marianne. L' araignée de mer: Roman. Paris: Denoël, 1993.

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Book chapters on the topic "L-Met"

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Hoffman, Robert M. "l-[Methyl-11C] Methionine-Positron-Emission Tomography (MET-PET)." In Methods in Molecular Biology, 267–71. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8796-2_20.

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van Gameren, Sandra. "Interview Loes L." In Leven met een psychisch zieke ouder, 71–76. Houten: Bohn Stafleu van Loghum, 2005. http://dx.doi.org/10.1007/978-90-313-6545-6_8.

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Braidotti, Rosi. "Meta(l)flesh." In The Future of Flesh, 241–61. New York: Palgrave Macmillan US, 2009. http://dx.doi.org/10.1057/9780230620858_13.

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Tait, A. Martin, Daryle H. Busch, and N. F. Curtis. "5,5,7,12,12,14-Hexamethyl-1,4,8,11-Tetraazacyclo-Tetradecane-2, ll-Diene (5,7,7,12,14,14-Me6 [141 -4,ll-Diene-l,4,8,1 l-N4 ) Complexes." In Inorganic Syntheses, 1–9. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132494.ch1.

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Fritz, Clemens. "The written wor(l)ds of men and women in early white Australia." In Studies in Language Variation, 245–67. Amsterdam: John Benjamins Publishing Company, 2008. http://dx.doi.org/10.1075/silv.2.20fri.

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Shipper, Frank, Charles C. Manz, and Greg L. Stewart. "W. L. Gore & Associates: Developing Global Teams to Meet Twenty-First-Century Challenges." In Shared Entrepreneurship, 267–84. New York: Palgrave Macmillan US, 2014. http://dx.doi.org/10.1057/9781137405807_15.

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Seaber, Luke. "If Men Do These Kind of Journalistic Feats…: Elizabeth L. Banks and Woman’s Work." In Incognito Social Investigation in British Literature, 169–88. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-50962-4_6.

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Ruoff, Cynthia. "Images of Water and the Sea in Tristan L’ Hermite’s “La Mer” and in Painting." In The Orchestration of the Arts — A Creative Symbiosis of Existential Powers, 241–54. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-017-3411-0_16.

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Iakovidis, Akis, and Nick Hadjiliadis. "IR-Raman and 1H NMR Spectra of Some Amino Acid Chelates of the Type cis-[(NH3)2Pt(amac)](NO3), Where amac is the Anions of Glycine, L-Alanine. L-Aminobutyric Acid, L-Valine And L- Norvaline and of Ternary Complexes of the Type cis- [(NH3)2Pt(nucl)(amac)](NO3), Where nucl-9-Methylguanine (9- MeG), 1-Methylcytosine (1-MeC)." In Fifth International Conference on the Spectroscopy of Biological Molecules, 181–82. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1934-4_67.

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Lipeck, U. W. "Comments on “A meta model transformation approach towards harmonisation in information system modelling” by J. L. H. Oei." In IFIP Advances in Information and Communication Technology, 128–29. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-0-387-34870-4_13.

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Conference papers on the topic "L-Met"

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Jiménez Caballero, Inmaculada. "Charles-Edouard Jeanneret miembro de l´OEUVRE." In LC2015 - Le Corbusier, 50 years later. Valencia: Universitat Politècnica València, 2015. http://dx.doi.org/10.4995/lc2015.2015.634.

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Resumen: Esta investigacióvn presenta la influencia en Charles-Edouard Jeanneret de su maestro Charles L´Eplattenier a través de dos instituciones: l´École d´Art de La Chaux-de-Fonds donde ambas figuras se encontraron y la asociación de la Suiza francófona l´OEUVRE, en la que los dos coincidieron también un breve espacio de tiempo en la misma época. La actividad en ambas instituciones representa la doble vertiente de un único proyecto para reformar los procesos artísticos ligados a los oficios artesanales; el propósito era incorporar al producto industrial producido en serie el valor añadido de su calidad artística, siguiendo el ejemplo de la Werkbund alemana. Para tal fin era necesario llevar a cabo una profunda reforma en el programa de enseñanza de dibujo en l´École d´Art, y desarrollar a la vez, una serie de acciones que permitieran visualizar los logros alcanzados. Su estrategia estaba apoyada en dos pilares: formación y propaganda. La presente investigación detalla de que manera Jeanneret participó en este proyecto a través de su intervención tanto en l´École d´Art y las nuevas estructuras para renovar la enseñanza del dibujo, como en la asociación l¨OEUVRE y sus distintos proyectos, A través de estas iniciativas encontramos el origen de algunos temas a los que Le Corbusier dedicará su atención; identificamos personajes que jugarán un papel importante en distintos momentos de su vida o proyectos y artículos que anunciarán propuestas teóricas y prácticas de sus trabajos posteriores. Abstract: This research presents the influence in Charles-Edouard Jeanneret of his master Charles L'Eplattenier in the context of two institutions. On one hand ´École d´Art de La Chaux-de-Fonds, where both figures met and where they established a first line of common work; and on the other hand, the association from the french-speaking Switzerland called l'Oeuvre, in which both briefly met. The activity in both institutions had the same goal and was in reality a single project: the reform of artistic processes bounded to the craft trades to provide the mass-produced industrial goods with the added value of artistic quality, following the example of the Deutscher Werkbund. In order to do this, it was necessary to carry out a profound reform of the drawing education program of l´Ecole d´Art and develop a series of propaganda actions allowing to visualize its achievements. Thus, the strategy was based on two pillars: education and propaganda. This research details how Jeanneret contributed to this project through his involvement in both, l´École d´Art’s renovation of drawing education and the Association l'Oeuvre’s various projects. Through them we discover the origin of some of the subjects that Le Corbusier will devote its attention to, characters that will play an important role in different moments of his life, or projects and articles that announce theoretical proposals or practices of his subsequent work. Palabras clave: Cours Supérieur; Nouvelle Section; Ateliers d´Art Réunis; L´OEUVRE. Keywords: Cours Supérieur; Nouvelle Section; Ateliers d´Art Réunis; L´OEUVRE. DOI: http://dx.doi.org/10.4995/LC2015.2015.634
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Sykes, David M., Andrew L. Carpenter, Jerald G. Wagner, John M. Gattoni, Kyle I. Merical, and Paul E. Yelvington. "1.25 L Turbocharged Diesel for Demanding Non-Road Applications." In ASME 2017 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icef2017-3536.

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A design process was defined and implemented for the rapid development of purpose-built, heavy-fueled engines using modern CAE tools. The first exercise of the process was the clean sheet design of the 1.25 L, three-cylinder, turbocharged AMD45 diesel engine. The goal of the AMD45 development program was to create an engine with the power density of an automotive engine and the durability of an industrial/military diesel engine. The AMD45 engine was designed to withstand 8000 hours of operation at 4500 RPM and 45 kW output, while weighing less than 100 kg. Using a small design team, the total development time to a working prototype was less than 15 months. Following the design phase, the AMD45 was fabricated and assembled for first prototype testing. The minimum-material-added design approach resulted in a lightweight engine with a dry weight 89 kg for the basic engine with fuel system. At 4500 RPM and an intake manifold pressure of 2.2 bar abs., the AMD45 produced 62 kW with a peak brake fuel-conversion efficiency greater than 34%. Predictions of brake power and efficiency from the design phase matched to within 5% of experimental values. When the engine is detuned to 56 kW maximum power, the use of multi-pulse injection and boost pressure control allowed the AMD45 to achieve steady state emissions (as measured over the ISO 8178 C1 test cycle) of CO and NOx+NMHC that met the EPA Tier 4 Non-road standard without exhaust after-treatment, with the exception of idle testing. PM emissions were also measured, and a sulfur-tolerant diesel particulate filter has been designed for PM after-treatment.
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Eiselt, Charles C., David T. Hoelzer, Yann de Carlan, Hieronymus Hein, Marta Serrano, Pascal Diano, Herbert Schendzielorz, and Andreas Seubert. "Comparison of Fracture Toughness Properties of Advanced Ferritic ODS-Alloys Based on 0.2T C(T) Specimen Tests." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63455.

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Based on the good experiences gained by using small specimens made of ferritic RPV materials, the Master Curve fracture toughness approach was applied to determine the fracture mechanical properties of oxide dispersion strengthened (ODS-) materials. A ferritic ODS-alloy (Fe-14Cr-1W-Ti-Y2O3) has been produced through the powder metallurgical production path via hot extrusion and hot isostatic pressing (HIP). Optimized oxide dispersion strengthened (ODS)-alloys have a promising potential to meet the foreseen requirements of components in future Gen IV power plants due to their high creep strength and swelling resistance under irradiation at elevated operational temperatures. The fracture toughness was characterized with mini 0.2T C(T) specimens in different material orientations (R-L / L-R) in the ductile-brittle and upper shelf region in the un-irradiated state, accounting especially for the ODS-material’s anisotropy as one key effect of manufacturing. Despite all tests were performed in orientation required by ASTM standards E 1921 and E 1820 not all validity criteria (e.g. height of yield strength, evenness of the crack, admissible K during testing or admissible stable crack growth) were met by the ODS-material: consequently, a valid T0 value and a standard-compliant Master Curve could not be determined for the ODS-material in the transition region especially in the respective R-L orientation, also due to a comparably low fracture toughness over the whole evaluated temperature range. Promising fracture toughness properties were obtained in the crack growth direction perpendicular to the prior main deformation (extrusion) direction, where a KJQ value of 196 MPa√m at T = 22°C was measured. Within the ductile regime, only a JQ = J0.2BL technical initiation toughness value could be calculated and at T = 22°C, a comparably large JQ of 137kJ/m2 is obtained for specimens with crack growth direction perpendicular to the extrusion direction, while in extrusion direction the toughness is again low. In addition two further ODS-materials (14YWT and PM2000) were tested and compared to the alloys above. Non-conformances of ODS relating to the material requirements in ASTM standards E1921 and E1820 were finally detected and explained.
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4

Liu, Hua-zhen, Wei Chen, Qi-ying Liu, Xia Zhang, Li-xiu Wang, and Cheng-wu Chi. "A NEW PEPTIDE THROMBIN INHIBITOR FROM STREPTOMYCES GRISEUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644330.

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A new peptide thrombin inhibitor was found in the Streptomyces griseus strain 254 isolated from a soil sample from Tongan, Fujian province, China, the inhibitor being a secondary metabolic product. The production of the inhibitor reached a maximum after 3 days culture of bacteria at 28°C in a rotary shaker. The inhibitor excreted in the culture filtrate was purified by absorption on macroporous resin, followed by ion exchange chromatography on DEAE-52, CM-32 cellulose, affinity chromatography on the immobilized thrombin and high performance liquid chromatography. The amino acid composition of the inhibitor was determined to be Val(2), Met(l), Ile(l), Leu(2) and Arg (1), similar to that of the amino acid residues around the reactive site of human antithrombin III, the critical plasma inhibitor of thrombin. The NH2-terminal residue of the inhibitor seems to be blocked by the alkyl group due to the negative reaction to ninhydrin, whereas the COO-terminal residue is most likely to be arginal because of that Arg was not found in the amino acid analysis, unless the peptide was oxidized by performic acid before acid hydrolysis. The chromogen substrates Bz-Phe-Val-Arg-PNA and Bz-Gly-Pro-Lys-PNA were used to determine the thrombin and plasmin activities, respectively. Besides thrombin, the purified inhibitor also exhibits a weak inhibitory activities on trypsin and much weak on plasmin, but not on chymotrypsin and other protein-ases.
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5

Qidwai, M. A. Siddiq, William R. Pogue, James P. Thomas, and Aashish Rohatgi. "Design and Fabrication of Multifunctional Structure-Power Composites for Marine Applications." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67697.

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Various subsystems in marine applications, especially unmanned underwater vehicles, compete for space. Multifunctional structure-battery (SB) composites combine structure and power functions through the use of high-performance fiber reinforced polymer layers and lithium ion cell batteries, to create volumetric opportunities for increase in overall power generation capacity and/or payload. This paper focuses on the design and fabrication aspects of the SB composites. The design objectives are to achieve or exceed structural performance of traditional marine composites while attaining a volumetric energy density of 50 Wh/L with similar buoyancy levels and dimensional sizes. The design process reveals that all four objectives can be achieved only if the components related to energy storage have the same mechanical and physical properties as the material being replaced. With commercially available batteries, at least three out of four objectives are met for the proposed SB designs. Selection of materials and fabrication methods are heavily influenced by the temperature limit of the battery cells, cell surface preparation for adhesion and load transfer, and power bussing layout. A companion paper addresses multifunctional performance characterization of these composites.
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6

Lv, Jinxu, Ning Lv, Huiping Guo, Zeting Hu, Geng Song, Yinying Cai, Heling Zhang, and Daji Li. "Uranium Radioactivity Measurement for Low-Level Wastewater Based on Ultra-Low Level Liquid Scintillation Analyzer." In 2020 International Conference on Nuclear Engineering collocated with the ASME 2020 Power Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icone2020-16143.

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Abstract In this paper, a method based on ultra-low level liquid scintillation analyzer for measuring uranium radioactivity in low-level radioactive wastewater is proposed. It can easily and quickly measure the radioactivity level of uranium in samples, and even distinguish the main isotopes of uranium. In low-level wastewater samples, if the uranium isotope has the same or similar composition and ratio to the natural uranium isotope, Comparing to the results in units of mass concentration given by laser-fluoremetry method, the liquid scintillation method can give the results in units of activity concentration, and these two results with different units can interconvert to each other. However, interconversion of results on above two measurement methods cannot be applied in low-level wastewater after uranium enrichment, because the proportion of isotopes with high specific activity in above wastewater, such as 234U and 235U, is significantly higher than that without enrichment. The measurement results in units of mass concentration will underestimate the uranium radioactivity level of the sample. The liquid scintillation method directly gives the results in units of radioactivity activity concentration, and it is more convenient to compare with relevant national standards to determine whether the emission standards are met. The lowest limit of detection of this method is 0.014 Bq L−1 within 600 min.
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7

Niyogi, Kalyan K., Stefan Anton, and Debabrata Mitra-Majumdar. "Prediction of Performance of Multi-Stage Orifice Assembly Using CFD Code." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81186.

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A multistage orifice assembly is often used in fluid systems in nuclear plants in order to achieve a specific flow rate for a large pressure drop. Such an assembly is usually designed with a number of orifices installed in series. Apart from the performance parameters, an important design consideration is to guarantee absence of potential for cavitation inside the assembly. An improperly designed multistage orifice assembly may create cavitation at the outlet of some stages of the assembly when the pressure at the vena contracta reaches a pressure close to the vapor pressure of the fluid at the operating temperature. The cavitation condition makes not only the operation noisy but also results in a significant reduction of equipment life. It is a challenge to the designer to select a set of orifices so that the cavitation condition is simultaneously met at all stages of the assembly. On the other hand, it is also a challenge to design each individual orifice in the assembly so that its influence to the next orifice is minimal. These challenges have been met in design of a replacement multistage orifice design for the centrifugal charging pump mini-flow line of a nuclear plant for a pressure drop of 2,595 psi (17.89 MPa) at 60 gpm (227 l/min) flow-rate. The orifice assembly has eleven stages accommodated within a pipe of 24 inches (600 mm) length, and each stage consists of a 3-dimensional compound orifice. The fluid analysis is performed using the CFD code FLUENT/UNS. The code numerically solves the Navier-Stokes equations of fluid motion to obtain the velocity field and pressure distribution within a modeled 2- and 3-dimensional geometry. Turbulence effects are modeled by relating time-varying Reynolds stresses to the mean bulk flow quantities using the standard k-epsilon model. The design was optimized by fine tuning the geometric parameters of the orifice units to minimize the potential for cavitation and at the same time maintaining a high accuracy in the flow-rate. The full-scale prototype was successfully tested to confirm the performance. Actual flows in the prototype tests were observed to be within a fraction of a gpm of the design flow-rate and pressure drop. After orifice assembly was installed in the plant system, there was absolutely no operating noise, as opposed to the original unit that was extremely noisy. A number of other multistage orifice assemblies have subsequently been designed for different power plants using similar computational technique with great success.
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8

Beceiro, Alvaro R., Elena Vico, and Emilio G. Neri. "The Radioactive Waste Management Programme in Spain." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4898.

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The paper will start with an overview of the organisational and financing framework established in Spain for the safe and efficient management of radioactive waste and decommissioning of nuclear installations. Since its creation by Royal Decree in 1984, ENRESA, the Spanish Radioactive Waste Management Agency, is in charge of both activities. ENRESA is a state owned company whose shareholders are CIEMAT (Centro de Investigaciones Energe´ticas, Medioambientales y Tecnolo´gicas) and the State Industrial Holding (SEPI), both governmental institutions. In Spain the Directorate General for Energy Policy and Mines of the Ministry of Economy (MINECO) plays the leading role in controlling nuclear activities, since it is the body responsible for awarding licenses and permits for installations and activities within the framework of the existing nuclear legislation. The Nuclear Safety Council (CSN) was set up in 1980 as the only competent body in matters of nuclear safety and radiological protection, and is generally responsible for the regulation and supervision of nuclear installations. Any license granted by MINECO is subjected to the mandatory and binding report of the CSN. The paper will review the steps undertaken for solving the national problems associated with the management of radioactive waste and decommissioning of nuclear installations, including uranium mining and milling facilities, and will address the lessons learnt from the activities developed by ENRESA and the future goals to be met. Regarding the L/ILW (Low and Intermediate Level Radioactive Waste) programme, the main milestones of El Cabril L/ILW disposal facility will be described highlighting the most relevant events as well as the foreseen activities, most of them focus on optimizing the capacity of the already operating installation. The elaboration and signature of a Protocol, at the end of 1999, for collaboration on the radiological Surveillance of Metallic Materials in order to detect the possible presence of radioactive materials is worth to be mentioned because of the involvement and agreement of several public and private organisations as well as the administration. Concerning the SF and HLW (Spent Nuclear Fuel and High Level radioactive Waste) programme, the solutions adopted in order to solve the insufficient capacity of the storage pools at NPPs will be described as well as the evolution of the final disposal programme since its beginning and the foreseen goals to be achieved before the year 2010. The last activities will deal with the experience gained during the decommissioning of Vandello´s I NPP and the future decommissioning projects. The decision taken in 2002 by the Spanish authorities to close down Jose´ Cabrera NPP in April 2006, before its 40 years lifetime, has had an impact on ENRESA’s activities.
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9

Wha Lin, Shu, J. Ware, H. Roberts, N. McGraw, W. McAllister, and D. Stafford. "EXPRESSION OF HUMAN FACTOR IX IN MAMMALIAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643567.

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Human factor IX has been expressed in mammalian cells. A cloned factor IX cDNA missing the first 15 nucleotides of the 5’ end was modified by in vitro mutagenesis to restore the missing codons and add the translation consensus sequence, CCACC, proposed by Kozak to be optimal for translational initiation. Additionally, Bgl II and BamHI sites were added immediately upstream of the CCACC sequence for ease of portability of the fragment. This modified cDNA was inserted into a bovine papillomavirus (BPV) vector under the control of a mouse met alio thionein promoter. The constructed plasmid pBPV-IX was used to transfect a mouse fibroblast cell line C127. After 3 weeks, the transformed foci were isolated and the established cell lines were grown in the presence or absence of vitamin K. Media was collected at 3 day intervals and assayed for factor IX activity in a one stage clotting assay. A standard curve was constructed using purified human factor IX. Cells grown in the presence of vitamin K (3 mg/L) exhibited an activity equivalent to 350 ng/ml of factor IX in the cell media; no (less than 3 ng/ml) activity was detectable in the absence of vitamin K. A monoclonal antibody column specific for the Ca++ dependent form of human factor IX allowed the isolation of approximately 7 ug of purified factor IX from approximately 100 ml of culture medium. Western blot analysis of the purified factor IX revealed 2 protein bands which reacted with a goat anti-human factor IX antibody as well as a human specific monoclonal antibody. One of the immunoreactive bands migrates with authentic human factor IX and the other migrates slower. This expression system provides a convenient way to produce suitable amounts of factor IX and mutated factor IX protein for functional analyses.
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10

Roan, Esra, Alex Bada, and Randy Buddington. "Mechanical Characterization of Preterm Neonate Pig Liver as a Function of High-Density Lipoprotein (HDL)." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39363.

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Elastography, a non-invasive imaging modality, utilizes mechanical properties of tissue as markers for disease diagnosis or staging. In the case of liver, there have been a number of studies focusing on the relationship between elastic mechanical properties and underlying disease, i.e. fibrosis and cirrhosis. In summary, these studies indicate the feasibility of elastographic tools in detecting liver diseases such as fibrosis and steatosis. There have not been any studies looking at the mechanical properties of the preterm neonate liver to date, which is important, because preterm neonates are at a greater risk for developing liver complications due to their aggressive dietary needs that are met with total parenteral nutrition (TPN). They use of elastography may be less from the use of elastographic tools since the concerns over noise levels in measurements resulting from abdominal wall thickness may be less influential. Therefore, it is necessary to establish basic preterm neonate liver mechanical properties. In this study, we measured the nonlinear (hyperelastic) mechanical properties of livers from preterm pigs that were fed common neaonatal diets, i.e. colostrum, total parenteral nutrition (TPN). 16 neonate pigs survived the feeding regime. Mechanical evaluation of 15 of these neonatal pigs was achieved with the use of uniaxial compression experiments at 0.01 s−1 strain rate. The livers averaging a weight of 34.7±7.0 (SD), were stored in phosphate buffered saline solution at 4°C until experimentation, which occurred within 30 minutes of the animal sacrifice. A minimum of three specimens from each liver was required for the computation of averaged mechanical properties. In addition to mechanical testing samples, blood serum was also obtained from these animals and common chemical parameters for liver health were measured (bilirubin, ALT, AST, HDL, LDL, etc.) Exponential form of the hyperelastic strain energy function, W = b1exp[b2(L2 + 2/L-3)], where bi are the material parameters and L is the stretch ratio, was utilized to describe the hyperelastic mechanical behavior of the preterm neonate pig livers. With the use of E = 6b1b2, a small-strain regime estimate of the elastic modulus of the neonate liver tissue was also computed. The mean b1 and b2 parameters are determined to be 97.00±44.15(SD) Pa and 1.90±0.28(SD) (n = 71). The mean elastic modulus exhibited an linear dependence on the HDL values obtained from chemical analysis of the blood serum. Moreover, although relatively weak, the ratio of the HDL over LDL also correlated with the elastic modulus. To our knowledge, this is the only study to date that has focused on the mechanical properties of preterm neonatal pigs and its correlation with liver lipid profile in neonates. Future work will focus on correlating this information with histology and then devising multi-scale material characterization approaches that link underlying neonatal liver structure to its overall mechanical properties.
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Reports on the topic "L-Met"

1

Schepker, Kristy. Complex Thermal Histories of L Melt Breccias NWA 5964 and NWA 6580. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1834.

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2

Xie, Xiao, Zhihao Zhang, Xue Wei, and Ming Yang. Efficacy and Safety of PD-(L)1 inhibitors plus Chemotherapy versus Chemotherapy in Treatment for Triple Negative Breast Cancer:A meta-Analysis of Randomized Control Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2020. http://dx.doi.org/10.37766/inplasy2020.12.0070.

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3

Adams, D. L. Analyzing powers and proton spin transfer coefficients in the elastic scattering of 800 MeV polarized protons from an L-type polarized deuteron target at small momentum transfers. Office of Scientific and Technical Information (OSTI), October 1986. http://dx.doi.org/10.2172/7010030.

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4

Kozhakhiyeva, Madina, Stefan Dragoev, Yasin Uzakov, and Almagul Nurgazezova. Improving of the Oxidative Stability and Quality of New Functional Horse Meat Delicacy Enriched with Sea Buckthorn (Hippophae rhamnoides) Fruit Powder Extracts or Seed Kernel Pumpkin (Cucurbita pero L.) Flour. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, January 2018. http://dx.doi.org/10.7546/crabs.2018.01.18.

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5

Kozhakhiyeva, Madina, Stefan Dragoev, Yasin Uzakov, and Almagul Nurgazezova. Improving of the Oxidative Stability and Quality of New Functional Horse Meat Delicacy Enriched with Sea Buckthorn (Hippophae rhamnoides) Fruit Powder Extracts or Seed Kernel Pumpkin (Cucurbita pero L.) Flour. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, January 2018. http://dx.doi.org/10.7546/grabs2018.1.18.

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6

Hutchinson, M. L., J. E. L. Corry, and R. H. Madden. A review of the impact of food processing on antimicrobial-resistant bacteria in secondary processed meats and meat products. Food Standards Agency, October 2020. http://dx.doi.org/10.46756/sci.fsa.bxn990.

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For meat and meat products, secondary processes are those that relate to the downstream of the primary chilling of carcasses. Secondary processes include maturation chilling, deboning, portioning, mincing and other operations such as thermal processing (cooking) that create fresh meat, meat preparations and ready-to-eat meat products. This review systematically identified and summarised information relating to antimicrobial resistance (AMR) during the manufacture of secondary processed meatand meat products (SPMMP). Systematic searching of eight literature databases was undertaken and the resultantpapers were appraised for relevance to AMR and SPMMP. Consideration was made that the appraisal scores, undertaken by different reviewers, were consistent. Appraisal reduced the 11,000 initially identified documents to 74, which indicated that literature relating to AMR and SPMMP was not plentiful. A wide range of laboratory methods and breakpoint values (i.e. the concentration of antimicrobial used to assess sensitivity, tolerance or resistance) were used for the isolation of AMR bacteria.The identified papers provided evidence that AMR bacteria could be routinely isolated from SPMMP. There was no evidence that either confirmed or refuted that genetic materials capable of increasing AMR in non-AMR bacteria were present unprotected (i.e. outside of a cell or a capsid) in SPMMP. Statistical analyses were not straightforward because different authors used different laboratory methodologies.However, analyses using antibiotic organised into broadly-related groups indicated that Enterobacteriaceaeresistant to third generation cephalosporins might be an area of upcoming concern in SPMMP. The effective treatment of patients infected with Enterobacteriaceaeresistant to cephalosporins are a known clinical issue. No AMR associations with geography were observed and most of the publications identified tended to be from Europe and the far east.AMR Listeria monocytogenes and lactic acid bacteria could be tolerant to cleaning and disinfection in secondary processing environments. The basis of the tolerance could be genetic (e.g. efflux pumps) or environmental (e.g. biofilm growth). Persistent, plant resident, AMR L. monocytogenes were shown by one study to be the source of final product contamination. 4 AMR genes can be present in bacterial cultures used for the manufacture of fermented SPMMP. Furthermore, there was broad evidence that AMR loci could be transferred during meat fermentation, with refrigeration temperatures curtailing transfer rates. Given the potential for AMR transfer, it may be prudent to advise food business operators (FBOs) to use fermentation starter cultures that are AMR-free or not contained within easily mobilisable genetic elements. Thermal processing was seen to be the only secondary processing stage that served as a critical control point for numbers of AMR bacteria. There were significant linkages between some AMR genes in Salmonella. Quaternary ammonium compound (QAC) resistance genes were associated with copper, tetracycline and sulphonamide resistance by virtue of co-location on the same plasmid. No evidence was found that either supported or refuted that there was any association between AMR genes and genes that encoded an altered stress response or enhanced the survival of AMR bacteria exposed to harmful environmental conditions.
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Cairo, Jessica, Iulia Gherman, and Paul Cook. The effects of consumer freezing of food on its use-by date. Food Standards Agency, July 2021. http://dx.doi.org/10.46756/sci.fsa.ret874.

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The current Food Standards Agency consumer guidance states that consumers can freeze pre-packed food right up to the “use-by” date and, once food has been defrosted, it should be consumed within 24 hours. This strategic review has collated relevant data to determine whether there is an increased risk in relation to freezing ready-to-eat and non-ready-to-eat foods on the use-by date compared to the day before the use-by date. The review has focused on how the shelf-life of a food is determined and the effects of freezing, thawing and refrigeration on foodborne pathogens, including Bacillus spp., Campylobacter spp., Clostridium botulinum, Clostridium perfringens, Listeria monocytogenes, Salmonella, pathogenic Escherichia coli and Shigella spp. In the UK, food business operators are responsible for setting the safe shelf-life of a food which, in practice, should take into consideration the consumer habits, as well as the factors affecting shelf-life, such as food product characteristics, food processing techniques, transport, retail and domestic food storage temperatures, and type of packaging. Some countries, such as Ireland, New Zealand and Canada specifically recommend including safety margins within shelf lives. This is used to maintain brand integrity because it ensures that the food is consumed in its optimum condition. The FSA has collaborated with other organisations in the production of several guidance documents; however, there is no explicit requirement for the consideration of a margin of safety when setting shelf-life. There is also no legal requirement in the UK to consider a safety margin when setting shelf-life. According to regulations, pathogens should not be present in sufficient levels to cause foodborne illness on the use-by date, as food should still be safe to eat on that day. Given that these requirements are met, the risk assessed in this report arises from the processes of freezing, thawing and subsequent refrigerated storage for a further 24 hours, and the potential for these to increase pathogen levels. In this review, it was found that there is a risk of additional growth of certain pathogens during the refrigerated storage period although the impact of freezing and thawing on the extent of this growth was not readily evident. This risk would relate specifically to ready-to-eat foods as cooking of non-ready-to-eat foods after defrosting would eliminate pathogens. This report explores the potential issues related to consumer freezing on the use-by date and identifies additional information or research required to understand the risks involved. Overall, there is little evidence to suggest a significant change in risk between consumers freezing ready-to-eat food on the use-by date compared to freezing the food on the day before the use-by date. Specific areas that merit further research include the risks due to low temperature survival and growth of L. monocytogenes. There is also a lack of research on the effects of freezing, defrosting and refrigeration on the growth and toxin production of non-proteolytic C. botulinum, and the growth of Salmonella during domestic freezing and thawing. Finally, more information on how food business operators set shelf-life would enable a better understanding of the process and the extent of the safety margin when determining shelf-life of ready-to-eat and non-ready-to-eat foods.
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8

[Model catalyst studies of active sites and meta L support interactions on vanadia and vanadia-supported catalysts]. Office of Scientific and Technical Information (OSTI), December 1991. http://dx.doi.org/10.2172/10191945.

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