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Journal articles on the topic 'L-methionine and D-methionine'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

Nonato, M. Cristina, Joanne Widom, and Jon Clardy. "Human methionine aminopeptidase type 2 in complex with l- and d-methionine." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (2006): 2580–83. http://dx.doi.org/10.1016/j.bmcl.2006.02.047.

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2

Brachet, P., F. Alvarado, and A. Puigserver. "Kinetic evidence for separate systems in transport of D- and L-methionine by rat small intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 252, no. 3 (1987): G320—G324. http://dx.doi.org/10.1152/ajpgi.1987.252.3.g320.

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The kinetics of D- and L-methionine uptake by rings of everted intestine in vitro are consistent with a saturable Michaelis-Menten component (Km = 11.7 and 1.7 mM; Vmax = 0.53 and 0.74 mumol X g-1 X min-1 for D- and L-methionine, respectively) plus a linear, diffusional one. All the data could be fit with a diffusion constant (Kd = 3.2 microliters X g-1 X min-1), which was essentially the same, independent of whether it was estimated by iteration or by using the extracellular marker, inulin. Similar results were obtained from in vivo perfusion experiments, except that the diffusional term was

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3

Hasegawa, Nobuharu, Yohei Yamaji, Masashi Minoda, and Motoki Kubo. "Effects of d-Methionine or l-Methionine on root hair of Brassica rapa." Journal of Bioscience and Bioengineering 95, no. 4 (2003): 419–20. http://dx.doi.org/10.1016/s1389-1723(03)80080-4.

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4

Ward, Mary, Helene McNulty, Joseph McPartlin, J. J. Strain, Donald G. Weir, and John M. Scott. "Effect of Supplemental Methionine on Plasma Homocysteine Concentrations in Healthy Men: A Preliminary Study." International Journal for Vitamin and Nutrition Research 71, no. 1 (2001): 82–86. http://dx.doi.org/10.1024/0300-9831.71.1.82.

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Hyperhomocysteinaemia is an established risk factor for vascular disease. The only source of homocysteine in humans is the amino acid methionine found in dietary protein. In an 8-week study, fasting plasma homocysteine concentrations were examined in a group of healthy male subjects (n = 6) under usual dietary conditions (weeks 1–4) and in response to weekly graded (25, 50 and 75mg/kg/d) supplementary methionine (weeks 5, 6, 7). Nutrient intakes, including methionine, were calculated from 4¥3 day food records. Under usual dietary conditions (mean methionine intake; 0.95 ± 0.51 mg/d) weekly mea

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5

Pisulewski, P. M., and P. J. Buttery. "The effect of increasing methionine supply on the methionine conversion to cyst(e)ine in sheep." British Journal of Nutrition 54, no. 1 (1985): 121–29. http://dx.doi.org/10.1079/bjn19850098.

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1. The conversion of methionine to cyst(e)ine was determined in sheep infused with different amounts of methionine (0-5 g/d) into the duodenum by assaying the incorporation of 36S from intravenously-infused L-[35S]methionine into cyst(e)ine in wool, plasma albumin and the free plasma pool.2. The percentage of cystine-S in the plasma originating from methionine increased linearly from 4.5 to 18 with increasing supplemental methionine supply.3. The percentage of cysteine-S in albumin increased from 15 to 50; methionine supply increased to 3 g/d but then remained constant, indicating that the tra

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6

Reis, P. J., D. A. Tunks, and L. F. Sharry. "Incorporation of abomasal and intravenous doses of [35S]cystine and [35S]methionine into wool." Journal of Agricultural Science 112, no. 3 (1989): 313–19. http://dx.doi.org/10.1017/s0021859600085762.

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SummaryThe fate of abomasal and intravenous doses of [35S]cystine and [35S]methionine was investigated in sheep to determine their relative efficacy as supplements for wool growth.Administration of L-[35S]cystine and L-, DL- and D-[35S]methionine via the abomasum produced similar patterns of 35S labelling in blood plasma. Only 10–16% of the administered 35S was excreted in urine over 7 days and 22–32% of the dose was incorporated into wool over 21 days. All isomers were utilized by the sheep with similar efficiency and it was concluded that D- and L-methionine and L-cystine are equally effecti

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7

Saunderson, C. Linda. "Effect of fasting and of methionine deficiency on L-methionine, DL-methionine and DL-2-hydroxy-4-methylthiobutanoic acid metabolism in broiler chicks." British Journal of Nutrition 57, no. 3 (1987): 429–37. http://dx.doi.org/10.1079/bjn19870050.

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1. Metabolism of L-[1-14C]methionine, DL-[l-14C]methionine and DL-[ 1-14C]2-hydroxy-4-methylthiobutanoic acid (DL-HMB) by broiler chicks which had been fasted overnight or given a methionine-deficient diet was compared with fed (control) birds.2. The excretion of 14C-labelled material, total 14CO2 exhaled, 14C incorporation into tissue proteins and the 14C-labelled material in perchloric-acid-soluble tissue fractions were measured 6 h after injection of the 14C-labelled materials.3. The incorporation of 14C into tissue proteins and the relative rates of conversion of D-methionine and DL-HMB to

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8

Vargas-Castro, Karen C., Ana M. Puebla Pérez, Irma I. Rangel-Salas, et al. "Antitumor Effect of Zwitterions of Imidazolium Derived from L-methionine in BALB/c Mice with Lymphoma L5178Y." Medicinal Chemistry 17, no. 1 (2020): 33–39. http://dx.doi.org/10.2174/1573406415666191206093754.

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Background: In the therapy of cancer, several treatments have been designed using nanomaterials, among which gold nanoparticles (AuNPs) have been featured as a promising antitumoral agent. Our research group has developed the synthesis of gold nanoparticles L-AuNPs and D-AuNPs stabilized with zwitterions of imidazolium (L-1 and D-1) derived from L-methionine and D-methionine. Because the stabilizer agent is chiral, we observed through circular dichroism that AuNPs also present chirality; such chirality as well as the fact that the stabilizing agent contains fragments of methionine and imidazol

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9

Bergström, M., H. Lundqvist, K. Ericson, et al. "Comparison of the Accumulation Kinetics of L-(Methyl-11C)-Methionine and D-(Methyl-11C)-Methionine in Brain Tumors Studied with Positron Emission Tomography." Acta Radiologica 28, no. 3 (1987): 225–29. http://dx.doi.org/10.1177/028418518702800301.

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Five patients with glioma were examined with positron emission tomography after the administration of 11C-L-methionine and at a following day with 11C-D-methionine. The rates of accumulation of the tracers were determined in the tumor and in the normal brain tissue according to a graphical technique of Patlak et coll. (24). The accumulation rates for L-methionine were on the average 2.4 times higher than those of D-methionine in the tumors. The corresponding ratio for normal brain tissue was 2.3. It is concluded that in this group of tumors without obvious blood-tumor-barrier breakdown, a ster

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10

Campbell, C. G., G. St. Jean, and Evan C. Titgemeyer. "D- VS L-methionine utilization by growing steers." Kansas Agricultural Experiment Station Research Reports, no. 1 (January 1, 1994): 12–13. http://dx.doi.org/10.4148/2378-5977.2005.

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11

Suga, Shunichi, Masahiro Suzuki, and Kenji Hanabusa. "Development of New D,L-Methionine-based Gelators." Journal of Oleo Science 67, no. 5 (2018): 539–49. http://dx.doi.org/10.5650/jos.ess17248.

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12

Saunderson, C. Linda. "Comparative metabolism of L-methionine, DL-methionine and DL-2-hydroxy 4-methylthiobutanoic acid by broiler chicks." British Journal of Nutrition 54, no. 3 (1985): 621–33. http://dx.doi.org/10.1079/bjn19850149.

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1. Metabolism, in broiler chicks, of DL-2-hydroxy 4-methylthiobutanoic acid (DL-HMB), DL-methionine and L-methionine was compared in vivo using 14C-labelled tracers.2. The distribution of L-[1-14C]methionine and DL-[1-14C]HMB in the major body tissues was examined for a period of 120 min after administration.3. The relative oxidation (14CO2, exhaled), excretion and incorporation into tissue protein of L-[l-14C]methionine, DL-[l-14C]methionine and DL-[1-14C]HMB were measured in fed birds.4. Tissue distribution of L-[1-14C]methionine and DL-[1-14C]HMB differed during 60–90 min following administ

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13

Aggrey, S. E., F. González-Cerón, R. Rekaya, and Y. Mercier. "Gene expression differences in the methionine remethylation and transsulphuration pathways under methionine restriction and recovery with D,L-methionine or D,L-HMTBA in meat-type chickens." Journal of Animal Physiology and Animal Nutrition 102, no. 1 (2017): e468-e475. http://dx.doi.org/10.1111/jpn.12779.

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14

Holland, Herbert L., Frances M. Brown, Damian Lozada, Benjamin Mayne, W. Rick Szerminski, and Aaron J. van Vliet. "Chloroperoxidase-catalyzed oxidation of methionine derivatives." Canadian Journal of Chemistry 80, no. 6 (2002): 633–39. http://dx.doi.org/10.1139/v02-025.

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Treatment of N-methoxycarbonyl C-carboxylate ester derivatives of L- and D-methionine and L-ethionine by chloroperoxidasehydrogen peroxide resulted in oxidation at sulfur to produce the (RS) sulfoxide in moderate to high diastereomeric excess. The (RS) sulfoxide of methionine was also obtained in moderate to high diastereomeric excess from (±)SO-N-methoxycarbonyl-L-methionine methyl ester sulfoxide by ester hydrolysis using α-chymotrypsin, Aspergillus sp. protease or subtilisin Carlsberg. Key words: amino acid oxidation, biocatalysis, biotransformation, chloroperoxidase, enzyme catalysis, lip

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15

Hirche, F., A. Schröder, B. Knoth, G. I. Stangl, and K. Eder. "Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism." British Journal of Nutrition 95, no. 5 (2006): 879–88. http://dx.doi.org/10.1079/bjn20061729.

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Methionine has been shown to increase plasma cholesterol in animals. In the present study, mechanisms were investigated by which methionine could alter cholesterol metabolism. In the first experiment, forty growing rats were fed four casein-based diets differing in methionine content (2·6, 3·5, 4·5 or 6·0 g/kg) for 14 d. In the second experiment, isolated rat hepatocytes were incubated in media supplemented with 50, 100 or 200 μmol/l methionine. Dietary methionine tended to increase plasma homocysteine concentrations in the rats (P=0·058). A weak positive correlation between circulating homocy

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16

Bouyssou, T., M. Pairet, M. Candau, and Y. Ruckebusch. "Effects of intraluminal nutrients on intestinal myoelectric activity in rabbits." American Journal of Physiology-Gastrointestinal and Liver Physiology 255, no. 1 (1988): G12—G17. http://dx.doi.org/10.1152/ajpgi.1988.255.1.g12.

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In the unanesthetized rabbit, intraluminal infusions of D- and L-methionine, L-tryptophan, D-glucose, D-xylose, and lactulose had a biphasic effect on small intestinal myoelectric activity. A phase of enhanced activity was followed by a phase of inhibition. The excitatory phase was mimicked by saline solutions equiosmolar to the test solutions. The subsequent inhibition was does dependent and significantly (P less than 0.01) longer for the passively absorbed D-methionine than for the L-stereoisomer. The inhibitory action of 10 mM D-glucose, 10 mM L-methionine, and 5 mM L-tryptophan was blocked

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17

Chung, T. K., and D. H. Baker. "Utilization of methionine isomers and analogs by the pig." Canadian Journal of Animal Science 72, no. 1 (1992): 185–88. http://dx.doi.org/10.4141/cjas92-024.

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A total of 72 pigs averaging 9.6 ± 1.4 kg were used to evaluate the efficacy of supplemental L-methionine (Met), D-Met, DL-Met and DL-methionine hydroxy analog free acid (DL-HMB) when added to a Met-deficient feather meal-corn-soybean meal-dried whey diet. Growth performance was similar for all diets containing isomolar levels of Met isomers and analogs, and the pigs utilized L-Met, D-Met, DL-Met and DL-HMB with the same molar efficiency. Key words: Pigs, methionine isomers and analogs, growth performance

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18

Berking, Stefan, Uwe Hoffmann, Mathias Schäfer, and Klaus Herrmann. "Methionine in pattern control of Hydra." Open Life Sciences 4, no. 4 (2009): 549–57. http://dx.doi.org/10.2478/s11535-009-0038-9.

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AbstractThe fresh water polyp Hydra is noted for its ability to regenerate missing body parts. Transplantation experiments indicate that the control of regeneration includes signalling over long distances. These signals appear to include diffusible morphogens, activators and inhibitors. In order to elucidate the nature of such signals, tissue of polyps was homogenized and fractionated. The fractions were tested for their ability to hinder head regeneration. The active factor within these fractions was determined to be methionine. Both the active fractions and L-methionine were found to antagon

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19

Stegink, Lewis D., Edward F. Bell, L. J. Filer, E. E. Ziegler, Dean W. Andersen, and Frances H. Seligson. "Effects of Equimolar Doses of L-Methionine, D-Methionine and L-Methionine-dl-Sulfoxide on Plasma and Urinary Amino Acid Levels in Normal Adult Humans." Journal of Nutrition 116, no. 7 (1986): 1185–92. http://dx.doi.org/10.1093/jn/116.7.1185.

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20

Kong, C., J. Y. Ahn, and B. G. Kim. "0958 Bioavailability of D-methionine relative to L-methionine for nursery pigs using slope-ratio assay." Journal of Animal Science 94, suppl_5 (2016): 461. http://dx.doi.org/10.2527/jam2016-0958.

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21

Rafii, Mahroukh, Paul B. Pencharz, Ronald O. Ball, Christopher Tomlinson, Rajavel Elango, and Glenda Courtney-Martin. "Bioavailable Methionine Assessed Using the Indicator Amino Acid Oxidation Method Is Greater When Cooked Chickpeas and Steamed Rice Are Combined in Healthy Young Men." Journal of Nutrition 150, no. 7 (2020): 1834–44. http://dx.doi.org/10.1093/jn/nxaa086.

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ABSTRACT Background In general, pulse protein is limiting in the indispensable amino acid methionine, and antinutritional factors in pulses can affect methionine bioavailability. Complementation with grains such as rice can improve pulse protein quality, but knowledge of methionine bioavailability in pulses and grains is necessary to correct for available methionine when planning and assessing dietary protein intake. Objectives The study objectives were to determine the bioavailability of methionine in rice and chickpeas separately and to assess the effect of complementation of chickpeas and r

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22

Tanaka, Mikiei, Yasuo Mukohata, and Seiji Yuasa. "Utilization of D-amino acids by Halobacterium halobium R1mR." Canadian Journal of Microbiology 35, no. 4 (1989): 508–11. http://dx.doi.org/10.1139/m89-078.

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Halobacterium halobium R1mR required L-amino acids such as methionine, leucine, valine, isoleucine, arginine, and lysine for growth. They also grew, with a lag phase of 15 to 20 days, when phenylalanine or tyrosine was omitted from the medium. This represents the first evidence that halophilic bacteria can grow on either D-methionine, D-phenylalanine, D-tyrosine, or D-leucine, each of which was substituted for the opposite enantiomer in the medium.Key words: halobacteria, D-amino acid.

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23

Hullo, Marie-Françoise, Sandrine Auger, Elie Dassa, Antoine Danchin, and Isabelle Martin-Verstraete. "The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, d- and l-methionine." Research in Microbiology 155, no. 2 (2004): 80–86. http://dx.doi.org/10.1016/j.resmic.2003.11.008.

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24

Viña, José, Angel Gimenez, Inmaculada R. Puertes, Esperanza Gasco, and Juan R. Viña. "Impairment of cysteine synthesis from methionine in rats exposed to surgical stress." British Journal of Nutrition 68, no. 2 (1992): 421–29. http://dx.doi.org/10.1079/bjn19920099.

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The activity of liver cystathionase (EC 4.4.1.1) was decreased after 3 d of stress induced by surgery. The rate of l-cysteine synthesis from l-methionine was significantly higher in isolated hepatocytes from controls than in hepatocytes from rats suffering from surgical stress. The half-life of l-[2(n)-3H]methionine was significantly higher in rats submitted to surgical stress than in controls. Plasma l-methionine: l-cystine ratio was higher in stressed rats than in controls. l-cystine uptake was significantly increased in the surgically-stressed rats when compared with the controls. All these

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25

Micovic, Zarko, Aleksandra Stamenkovic, Tamara Nikolic, et al. "The Effects of Subchronic Methionine Overload Administered Alone or Simultaneously with L-cysteine or N-acetyl-L-cysteine on Body Weight, Homocysteine Levels and Biochemical Parameters in the Blood of Male Wistar Rats." Serbian Journal of Experimental and Clinical Research 17, no. 3 (2016): 215–24. http://dx.doi.org/10.1515/sjecr-2016-0017.

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AbstractHyperhomocysteinemia (HHC), both basal and after methionine load, may occur due to genetic disorders or deficiencies of nutrients that affect the remethylation or trans-sulphuration pathways during methionine metabolism. HHC is involved in the pathogenesis of many illnesses as a result of its prooxidative effect and its impairment of antioxidative protection. The aim was to examine the effects of subchronic methionine overload on the body weight and standard biochemical parameters in rat serum and to examine whether simultaneous subchronic intraperotoneal administration of methionine a

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26

Rodríguez-Aparicio, L. B., A. Reglero, and J. M. Luengo. "Uptake of N-acetylneuraminic acid by Escherichia coli K-235. Biochemical characterization of the transport system." Biochemical Journal 246, no. 2 (1987): 287–94. http://dx.doi.org/10.1042/bj2460287.

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Kinetic measurement of the uptake of N-acetyl[4,5,6,7,8,9-14C]neuraminic acid by Escherichia coli K-235 was carried out in vivo at 37 degrees C in 0.1 M-Tris/maleate buffer, pH 7.0. Under these conditions uptake was linear for at least 30 min and the Km calculated for sialic acid was 30 microM. The transport system was osmotic-shock-sensitive and was strongly inhibited by uncouplers of oxidative phosphorylation [2,4-dinitrophenol (100%); NaN3 (66%]) and by the metabolic inhibitors KCN (84%) and sodium arsenate (76%). The thiol-containing compounds mercaptoethanol, glutathione, cysteine, dithio

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27

Vicens, Margarita, Amparo Caubet, and Virtudes Moreno. "Interaction of Pd(II) and Pt(II) Amino Acid Complexes With Dinucleotides." Metal-Based Drugs 4, no. 1 (1997): 43–50. http://dx.doi.org/10.1155/mbd.1997.43.

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The interaction of the dinucleotides d(ApG) and d(ApA) with [Pd(aa)Cl2], where aa = L- or D-histidine or the methyl ester of L-histidine, and with [Pt(Met)Cl2], where Met = L-methionine was studied by H1 and C13 NMR and CD measurements. In the case of the L-histidine and L-histidineOMe, the reaction with d(ApG) appeared to give the bifunctional adducts Pd(L-Histidine)N1(1)N7(2) and Pd(L-HisOMe)N1(1)N7(2), but the behavior with D-histidine suggested the formation of the monofunctional adduct Pd(D-His)N7(2). The reaction of L-histidine with d(ApA) seemed to form the bimetallic adduct (L-His)PdN7

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28

Campbell, C. G., E. C. Titgemeyer, and G. St-Jean. "Efficiency of D- vs L-methionine utilization by growing steers." Journal of Animal Science 74, no. 10 (1996): 2482. http://dx.doi.org/10.2527/1996.74102482x.

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29

Natelson, Samuel, and Ethan A. Natelson. "Preparation of d-, dl-, and l-homoserine lactone from methionine." Microchemical Journal 40, no. 2 (1989): 226–32. http://dx.doi.org/10.1016/0026-265x(89)90074-x.

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30

Kerper, L. E., N. Ballatori, and T. W. Clarkson. "Methylmercury transport across the blood-brain barrier by an amino acid carrier." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 262, no. 5 (1992): R761—R765. http://dx.doi.org/10.1152/ajpregu.1992.262.5.r761.

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The mechanism by which methylmercury (MeHg) crosses the blood-brain barrier was examined in the rat. Previous studies demonstrated that intravenous injection of L-cysteine with MeHg accelerates MeHg uptake into brain. Since the complex of MeHg with L-cysteine is structurally similar to L-methionine, a substrate for the L (leucine-preferring) amino acid transport system, this carrier may be involved in MeHg uptake. To examine this hypothesis, the rapid carotid infusion technique was used in the anesthetized rat. The concentration dependence of 203Hg uptake into brain after injection of Me203Hg-

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31

Chin, Keigi, Sakino Toue, Yasuko Kawamata, et al. "A 4-Week Toxicity Study of Methionine in Male Rats." International Journal of Toxicology 34, no. 3 (2015): 233–41. http://dx.doi.org/10.1177/1091581815583678.

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To examine 4-week toxicity of l-methionine (methionine), 5-week-old Fisher strain male rats were fed on diets containing 0, 0.1, 0.3, 0.9, 2.7 (w/w) of added methionine. Although no deaths were recorded, the highest dose of methionine (2.7% [w/w] of diet) reduced food intake and significantly suppressed growth rate. Growth suppression was characterized by an increase in hemolysis, splenic, and hepatic accumulation of hemosiderin, hemolytic anemia, and promotion of hematopoiesis. Other changes observed in the highest methionine intake group were a decrease in white blood cell count, thymus atro

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32

Hasegawa, Hiroshi, Yoshihiko Shinohara, Kenji Akahane, and Takao Hashimoto. "Direct Detection and Evaluation of Conversion of D-Methionine into L-Methionine in Rats by Stable Isotope Methodology." Journal of Nutrition 135, no. 8 (2005): 2001–5. http://dx.doi.org/10.1093/jn/135.8.2001.

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Hasegawa, Hiroshi, Yoshihiko Shinohara, Kenji Akahane, and Takao Hashimoto. "Determination of d- and l-enantiomers of methionine and [2H3]methionine in plasma by gas chromatography–mass spectrometry." Journal of Chromatography B 823, no. 2 (2005): 203–8. http://dx.doi.org/10.1016/j.jchromb.2005.06.010.

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34

Bergstr�m, M., C. Muhr, K. Ericson, et al. "The normal pituitary examined with positron emission tomography and (methyl-11C)-L-methionine and (methyl-11C)-D-methionine." Neuroradiology 29, no. 3 (1987): 221–25. http://dx.doi.org/10.1007/bf00451757.

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35

Gonzalez-Esquerra, R., and S. Leeson. "Effect of arginine:lysine and methionine source on amino acid digestibility and response to dietary electrolytes in chronically or acutely heat-stressed broilers." Canadian Journal of Animal Science 86, no. 2 (2006): 263–71. http://dx.doi.org/10.4141/a05-048.

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In two experiments, the effects of arginine:lysine, NaHCO3 and methionine source on performance and amino acid digestion of heat-stressed broilers were studied. In exp. 1, corn/soy diets with argine:lysine (Arg:Lys) of 1.10, 1.25 and 1.40 were fed from 21 to 42 d. Diets were supplemented with 2-hydroxy-4-(methylthio)-butanoic acid (HMB) or DL-Methionine (DLM) with NaHCO3 at 0 or 1.04%. Ten replicates per treatment of four birds per cage were maintained at 31.7 ± 0.9°C. From 21 to 28 d weight gain (BWG), feed consumption and feed-to-gain (FCR) were unaffected by diet treatment. Methionine sourc

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36

Htoo, John K., John Mathai, Laia Blavi, Yanhong Liu, Caroline González-Vega, and Hans H. Stein. "210 Effects of D-methionine compared with L-methionine on N retention, gut morphology and antioxidant status of weaned pigs." Journal of Animal Science 98, Supplement_3 (2020): 73. http://dx.doi.org/10.1093/jas/skaa054.130.

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Abstract A N-balance study was conducted to compare the effect of D-methionine (D-Met) or L-methionine (L-Met) supplementation on N balance, gut morphology and antioxidant status of weaned pigs. Fifty-six weaned barrows (10.5 ± 1.2 kg initial BW) were allotted to 7 diets in 2 blocks. A Met-deficient basal diet (BD; 0.24% standardized ileal digestible (SID) Met) but adequate in other AA, was supplemented with 3 graded levels (0.036, 0.072, and 0.108%) of D-Met or L-Met. After a 7-d adaptation, feces and urine were collected quantitatively for 5 d to determine N balance. At the completion of the

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37

Ahlström, H., P. U. Malmström, H. Letocha, J. Andersson, B. Långström, and S. Nilsson. "Positron Emission Tomography in the Diagnosis and Staging of Urinary Bladder Cancer." Acta Radiologica 37, no. 1P1 (1996): 180–85. http://dx.doi.org/10.1177/02841851960371p137.

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Purpose: Evaluation of positron emission tomography (PET) using 18F-2-fluoro-2-deoxy-d-glucose (18FDG) and l-methyl-11C-methionine in the diagnosis and staging of urinary bladder carcinoma. Material and Methods: Twenty-three patients with biopsy-proven urinary bladder carcinoma were examined with PET after intravenous injection of 11C-methionine; 2 were also examined with 18FDG. The results from the PET investigations were compared with CT or MR findings and TNM classification before and after treatment. Results: The urinary excretion of 18FDG prevented distinction of the primary tumour from t

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38

Katz, Edward, and Aline Betancourt. "Induction of tyrosinase by L-methionine in Streptomyces antibioticus." Canadian Journal of Microbiology 34, no. 12 (1988): 1297–303. http://dx.doi.org/10.1139/m88-227.

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Investigations were carried out to establish conditions favorable for the formation of tyrosinase, an inducible metalloenzyme synthesized by Streptomyces antibioticus. It was determined that the size of the inoculum and age of the culture as well as the temperature of incubation were important factors for enzyme synthesis. Induction of tyrosinase by S. antibioticus appears to be specific for L-methionine with maximal enzyme synthesis observed at 0.1 mM. Addition of CuSO4 and D-glucose at the time of induction also are important for increased enzyme activity. Inhibition of tyrosinase synthesis

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Bhatia, Surabhi, Bianca Knoch, Jenny Wong, et al. "Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease." Biochemical Journal 442, no. 3 (2012): 713–21. http://dx.doi.org/10.1042/bj20111166.

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ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown. Specific methionine residues may inhibit lipid peroxidation by reducing radical-propagating L-OOHs (lipid hydroperoxides) to non-reactive hydroxides via a reaction that generates MetSO (methionine sulfoxide). Since apoD has three conserved methionine residues (Met49, Met93 and Met157), we generated recombinant proteins with either one or all methionine residues replaced by alanine and assessed their capacity to reduce HpETE

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Mustofin Akhyar, Boedi S. Rahardja, Rahayu Kusdarwati,. "Pengaruh Penambahan Vitamin B pada Media Blotong 12 Kering terhadap Pertumbuhan Populasi Dunaliella salina [Effect of Adding Vitamin B on Blotong Dry Media 12 Againts Population Growth Dunaliella salina]." Jurnal Ilmiah Perikanan dan Kelautan 3, no. 1 (2019): 73. http://dx.doi.org/10.20473/jipk.v3i1.11628.

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Abstract Dunaliella salina is one natural food that is good enough for the larvae of sea urchins and also can be used as food Brachionus plicatilis and Artemia in aquaculture feed Artemia. Blotong is precipitated in the process of purification juice before cooking and crystallized into sugar. Purification is a process to separate the juice from dirt or fibers. Sugarcane is used as fertilizer by using oven dried first. Vitamin B is needed some algae to build 12 proteins and essential as a coenzyme necessary for DNA synthesis in the formation of new cells. Vitamin B is a 12 coenzyme B -dependent

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Isab, Anvarhusein A., and Mohamed I. M. Wazeer. "A13C NMR study of the interactions of Ag13CN and Ag(CN)2–with thiomalic acid, L-methionine and DL-selenomethionine." Spectroscopy 19, no. 5,6 (2005): 275–81. http://dx.doi.org/10.1155/2005/850959.

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Complexation of Ag+as AgNO3, solid AgCN and Ag(CN)2–by labeled and unlabeled L-methionine, DL-selenomethionine and d,l-thiomalate were studied by nuclear magnetic resonance methods. The13C NMR indicates that only Ag+react with the both L-methionine, DL-selenomethionine at neutral and higher pH via CO2–and S or Se atom forming a chelate. The Ag(CN)2–and AgCN do not bind to either of these two ligands at any pH. The Ag13CN, which is an insoluble polymer, can react with thiomalate to form chelate complexes at neutral pH. Various structures for the chelate formations are proposed.

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Dalhus, Bjørn, and Carl Henrik Görbitz. "Molecular aggregation in crystalline 1:1 complexes of hydrophobic D- and L-amino acids. I. The L-isoleucine series." Acta Crystallographica Section B Structural Science 55, no. 3 (1999): 424–31. http://dx.doi.org/10.1107/s0108768198013494.

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The amino acid L-isoleucine has been cocrystallized with seven selected D-amino acids including D-methionine [L-isoleucine–D-methionine (1/1), C6H13NO2.C5H11NO2S, amino-acid side chain R = —CH2—CH2—S—CH3] and a homologous series from D-alanine [L-isoleucine–D-alanine (1/1), C6H13NO2.C3H7NO2, R = —CH3] through D-α-aminobutyric acid [L-isoleucine–D-α-aminobutyric acid (1/1), C6H13NO2.C4H9NO2, R = —CH2—CH3] and D-norvaline [L-isoleucine–D-norvaline (1/1), C6H13NO2.C5H11NO2, R = —CH2—CH2—CH3] to D-norleucine [L-isoleucine–D-norleucine (1/1), C6H13NO2.C6H13NO2, R = —CH2—CH2—CH2—CH3] with linear sid

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Lee, Mingyung, Hyesun Park, Jung Min Heo, Ho Jun Choi, and Seongwon Seo. "Multi-tissue transcriptomic analysis reveals that L-methionine supplementation maintains the physiological homeostasis of broiler chickens than D-methionine under acute heat stress." PLOS ONE 16, no. 1 (2021): e0246063. http://dx.doi.org/10.1371/journal.pone.0246063.

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The objective of this study was to compare the effects of supplementation with two methionine isoforms, L-methionine (L-Met) or D-methionine (D-Met), on transcriptome expression in broiler chickens under acute heat stress. A total of 240 one-day-old chicks were randomly assigned to one of four treatments in a 2 × 2 factorial arrangement: thermo-neutral vs. acute heat-stress and L-Met vs. D-Met supplementation. On day 14, the heat-stressed group was exposed to 32°C for 5 h, while the others remained at 25°C. Six chicks were randomly selected per treatment and total RNA was isolated from whole b

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Nielsen, Henrik K., D. De Weck, P. A. Finot, R. Liardon, and R. F. Hurrell. "Stability of tryptophan during food processing and storage." British Journal of Nutrition 53, no. 2 (1985): 281–92. http://dx.doi.org/10.1079/bjn19850035.

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1. The stability of tryptophan was evaluated in several different food model systems using a chemical method (high pressure liquid chromatography after alkaline-hydrolysis) and rat assays. Losses of tryptophan were compared with the losses of lysine and methionine.2. Whey proteins stored in the presence of oxidizing lipids showed large losses of lysine and extensive methionine oxidation but only minor losses of tryptophan as measured chemically. The observed decrease in bioavailable tryptophan was explained by a lower protein digestibility.3. Casein treated with hydrogen peroxide to oxidize al

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SIMMONS-WILLIS, Tracey A., Albert S. KOH, Thomas W. CLARKSON, and Nazzareno BALLATORI. "Transport of a neurotoxicant by molecular mimicry: the methylmercury–l-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2." Biochemical Journal 367, no. 1 (2002): 239–46. http://dx.doi.org/10.1042/bj20020841.

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Methylmercury (MeHg) readily crosses cell membrane barriers to reach its target tissue, the brain. Although it is generally assumed that this rapid transport is due to simple diffusion, recent studies have demonstrated that MeHg is transported as a hydrophilic complex, and possibly as an l-cysteine complex on the ubiquitous L-type large neutral amino acid transporters (LATs). To test this hypothesis, studies were carried out in Xenopus laevis oocytes expressing two of the major L-type carriers in humans, LAT1—4F2 heavy chain (4F2hc) and LAT2—4F2hc. Oocytes expressing LAT1—4F2hc or LAT2—4F2hc d

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Mederos, A., E. Medina, J. J. Alvarez Colomer, and F. Brito. "Equilibria in aqueous solution between beryllium(II) and d,l-aspartic acid and d,l-methionine." Polyhedron 8, no. 16 (1989): 2017–22. http://dx.doi.org/10.1016/s0277-5387(00)80497-0.

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Wang, Shiow Y., and Dean Der-Syh Tzeng. "Methionine-Riboflavin Mixtures with Surfactants and Metal Ions Reduce Powdery Mildew Infection in Strawberry Plants." Journal of the American Society for Horticultural Science 123, no. 6 (1998): 987–91. http://dx.doi.org/10.21273/jashs.123.6.987.

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Foliar application of a mixture of methionine (1 mm) and riboflavin (26.6 μm) reduced the severity of powdery mildew [Sphaerotheca macularia (Wallr. ex Fr.) Jacz. f. sp. fragariae] infection in `Earliglow' strawberry (Fragaria × ananassa Duch.) plants. Efficacy of this mixture on controlling powdery mildew infection was enhanced by supplements of copper, iron, and surfactants [sodium dodecyl sulfate (SDS), Triton X-100, Tween-20, or oxyalkylenemethylsiloxane (Silwet L-77)]. Free-radical scavengers (n-propyl gallate, thiourea) and antioxidants (α-tocopherol, β-carotene) reduced the efficacy of

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Bergström, Mats, Carin Muhr, Per Olov Lundberg, et al. "Amino Acid Distribution and Metabolism in Pituitary Adenomas Using Positron Emission Tomography with D-[11C]Methionine and L-[11C]Methionine." Journal of Computer Assisted Tomography 11, no. 3 (1987): 384–89. http://dx.doi.org/10.1097/00004728-198705000-00003.

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Romanet, Stella, Jörg R. Aschenbach, Robert Pieper, et al. "Dietary Supplementation of dl-Methionine Potently Induces Sodium-Dependent l-Methionine Absorption in Porcine Jejunum Ex Vivo." Journal of Nutrition 150, no. 7 (2020): 1782–89. http://dx.doi.org/10.1093/jn/nxaa115.

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ABSTRACT Background Methionine is an essential amino acid (AA) with many fundamental roles. Humans often supplement l-Met, whereas dl-Met and dl-2-hydroxy-4-(methylthio)butanoic acid (dl-HMTBA) are more frequently used to supplement livestock. Objectives The study aimed to investigate whether dietary Met source alters the absorptive capacity for Met isomers in the small intestine of piglets. Methods A total of 27 male 10-wk-old piglets in 3 feeding groups received a diet supplemented with 0.21% dl-Met, 0.21% l-Met, or 0.31% dl-HMTBA to meet the Met + cystine requirement. After ≥10 d, absorptiv

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Wu, Calvin, Kamakshi V. Gopal, Ernest J. Moore, and Guenter W. Gross. "Antioxidants l-carnitine and d-methionine modulate neuronal activity through GABAergic inhibition." Journal of Neural Transmission 121, no. 7 (2014): 683–93. http://dx.doi.org/10.1007/s00702-014-1170-x.

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