Log in

Relevant bibliographies by topics / L1 trigger / Journal articles

To see the other types of publications on this topic, follow the link: L1 trigger.

Journal articles on the topic 'L1 trigger'

Author: Grafiati

Published: 13 April 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'L1 trigger.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Wightman, Andrew, Geoffrey Smith, Kelci Mohrman, and Charles Mueller. "Trigger Rate Monitoring Tools at CMS." EPJ Web of Conferences 214 (2019): 01047. http://dx.doi.org/10.1051/epjconf/201921401047.

Full text

Abstract:

One of the major challenges for the Compact Muon Solenoid (CMS)experiment, is the task of reducing event rate from roughly 40 MHz down to a more manageable 1 kHz while keeping as many interesting physics events as possible. This is accomplished through the use of a Level-1 (L1) hardware based trigger as well as a software based High-Level Trigger (HLT). Monitoring and understanding the output rates of the L1 and HLT triggers is of key importance for determining the overall performance of the trigger system and is intimately tied to what type of data is being recorded for physics analyses. We p

APA, Harvard, Vancouver, ISO, and other styles

2

Koulouris, A., Y. Afik, A. Armbruster, et al. "Commissioning of the new muon-to-central-trigger-processor interface at ATLAS." Journal of Instrumentation 18, no. 03 (2023): C03020. http://dx.doi.org/10.1088/1748-0221/18/03/c03020.

Full text

Abstract:

Abstract The ATLAS trigger system includes a Level-1 (L1) trigger based on custom electronics and firmware, and a high-level software trigger running on off-the-shelf hardware. The L1 trigger system uses information from the forward detectors, the calorimeters and the muon trigger detectors. Once information from all muon trigger sectors has been received, trigger candidate multiplicities are calculated by the Muon-to-Central-Trigger-Processor Interface (MUCTPI). Muon multiplicity information is sent to the Central-Trigger-Processor (CTP) and trigger objects are sent to the L1 Topological Trig

APA, Harvard, Vancouver, ISO, and other styles

3

Ghete, V. M., and Cms Collaboration. "The CMS L1 Trigger emulation software." Journal of Physics: Conference Series 219, no. 3 (2010): 032009. http://dx.doi.org/10.1088/1742-6596/219/3/032009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Dordevic, Milos. "The CMS Trigger System." Journal of Physics: Conference Series 2375, no. 1 (2022): 012003. http://dx.doi.org/10.1088/1742-6596/2375/1/012003.

Full text

Abstract:

Abstract The CMS experiment at CERN uses a two-stage triggering system composed of the Level-1 (L1), instrumented with custom-designed hardware boards with an output rate of 100 kHz, and the High Level Trigger (HLT), streamlined version of the offline software reconstruction that runs on the computing farm, allowing to store around 1.5 kHz of rate. New trigger algorithms and new features, as well as optimized trigger menus at both L1 and HLT are mandatory in order to be able to successfully record the events at higher data loads due to increasing luminosity and pileup at the LHC in Run 3. Many

APA, Harvard, Vancouver, ISO, and other styles

5

Donato, Silvio. "CMS trigger performance." EPJ Web of Conferences 182 (2018): 02037. http://dx.doi.org/10.1051/epjconf/201818202037.

Full text

Abstract:

During its second run of operation (Run 2), started in 2015, the LHC will deliver a peak instantaneous luminosity that may reach 2 · 1034 cm-2s-1 with an average pileup of about 55, far larger than the design value. Under these conditions, the online event selection is a very challenging task. In CMS, it is realized by a two-level trigger system: the Level-1 (L1) Trigger, implemented in custom-designed electronics, and the High Level Trigger (HLT), a streamlined version of the offine reconstruction software running on a computer farm. In order to face this challenge, the L1 trigger has been th

APA, Harvard, Vancouver, ISO, and other styles

6

Portalès, Louis. "L1 Triggering on High-Granularity Information at the HL-LHC." Instruments 6, no. 4 (2022): 71. http://dx.doi.org/10.3390/instruments6040071.

Full text

Abstract:

The CMS collaboration is building a high-granularity calorimeter (HGCAL) for the endcap regions as part of its planned upgrade for the High-Luminosity LHC. The calorimetric data will form part of the Level-1 trigger (hardware) of the CMS experiment, reducing the event rate from the nominal 40 MHz to 750 kHz with a decision time (latency) of 12.5 microseconds. In addition to basic tracking information, which will also be available in the Level-1 trigger system, the use of particle-flow techniques will be facilitated as part of the trigger system. Around 1-million “trigger channels” are read at

APA, Harvard, Vancouver, ISO, and other styles

7

Hoff, J., M. Johnson, R. Lipton, et al. "Design for a L1 tracking trigger for CMS." Journal of Instrumentation 8, no. 02 (2013): C02004. http://dx.doi.org/10.1088/1748-0221/8/02/c02004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Cieri, D., J. Brooke, M. Grimes, et al. "L1 track finding for a time multiplexed trigger." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 824 (July 2016): 268–69. http://dx.doi.org/10.1016/j.nima.2015.09.117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kumar, Piyush, and Bhawna Gomber. "The CMS Level-1 Calorimeter Trigger for the HL-LHC." Instruments 6, no. 4 (2022): 64. http://dx.doi.org/10.3390/instruments6040064.

Full text

Abstract:

The High-Luminosity LHC (HL-LHC) provides an opportunity for a pioneering physics program to harness an integrated luminosity of 4000 fb−1 of ten years of operations. This large volume of collision data will help in high precision measurements of the Standard Model (SM) and the search for new and rare physics phenomena. The harsh environment of 200 proton–proton interactions poses a substantial challenge in the collection of these large datasets. The HL-LHC CMS Level-1 (L1) trigger, including the calorimeter trigger, will receive a massive upgrade to tackle the challenge of a high-bandwidth an

APA, Harvard, Vancouver, ISO, and other styles

10

Hoff, J., M. Johnson, R. Lipton, and G. Magazzu. "Readout chip for an L1 tracking trigger using asynchronous logic." Journal of Instrumentation 7, no. 08 (2012): C08004. http://dx.doi.org/10.1088/1748-0221/7/08/c08004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Bourrion, O., N. Arbor, G. Conesa-Balbastre, C. Furget, R. Guernane, and G. Marcotte. "The ALICE EMCal L1 trigger first year of operation experience." Journal of Instrumentation 8, no. 01 (2013): C01013. http://dx.doi.org/10.1088/1748-0221/8/01/c01013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Dong, Ling, Suzhen Chen, and Melitta Schachner. "Single chain Fv antibodies against neural cell adhesion molecule L1 trigger L1 functions in cultured neurons." Molecular and Cellular Neuroscience 22, no. 2 (2003): 234–47. http://dx.doi.org/10.1016/s1044-7431(02)00033-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Ammendola, R., D. Battista, G. Paoluzzi, et al. "The NA62 level 0 calorimetric trigger fast readout implementation, commissioning and data taking performances." Journal of Instrumentation 18, no. 02 (2023): C02049. http://dx.doi.org/10.1088/1748-0221/18/02/c02049.

Full text

Abstract:

Abstract The NA62 experiment at the CERN SPS aims to measure the branching ratio of the very rare kaon decay K + → π + ν ν ¯ . The Calorimetric Level 0 Trigger identifies clusters in the electromagnetic and hadronic calorimeters. Along with the trigger data sent to the L0 Trigger Processor, readout data is collected to be sent to the L1 software trigger. In this work we present the novel implementation of the readout data collection and forwarding system in the multiple layers of the calorimetric trigger structure. We will also present the commissioning of the system and the performance evalua

APA, Harvard, Vancouver, ISO, and other styles

14

Perrella, S., Y. Afik, A. Armbruster, et al. "Integration and commissioning of the ATLAS Muon-to-Central-Trigger-Processor Interface for Run-3." Journal of Instrumentation 17, no. 04 (2022): C04006. http://dx.doi.org/10.1088/1748-0221/17/04/c04006.

Full text

Abstract:

Abstract The Muon-to-Central Trigger Processor Interface was completely redesigned as part of the ATLAS Level-1 trigger upgrade for Run 3 of the Large Hadron Collider. The new system is implemented as a single AdvancedTCA module, using three large state-of-the-art FPGAs and high-density fiber-optic modules. Trigger information from the muon trigger detectors are received through 208 high speed links, while 60 links are used to send processed trigger information to the L1 Topological Trigger Processor and the Central Trigger Processor. Extensive integration tests with all input and output syste

APA, Harvard, Vancouver, ISO, and other styles

15

Skambraks, Sebastian, Steffen Bähr, Jürgen Becker, et al. "A 3D track finder for the Belle II CDC L1 trigger." Journal of Physics: Conference Series 1525 (April 2020): 012102. http://dx.doi.org/10.1088/1742-6596/1525/1/012102.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Barrio, J. A., O. Blanch, J. Boix, et al. "Analogue sum ASIC for L1 trigger decision in Cherenkov Telescope cameras." Journal of Instrumentation 10, no. 02 (2015): C02016. http://dx.doi.org/10.1088/1748-0221/10/02/c02016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

PAVLENKO, ANETA, SCOTT JARVIS, SVITLANA MELNYK, and ANASTASIA SOROKINA. "Communicative relevance: Color references in bilingual and trilingual speakers." Bilingualism: Language and Cognition 20, no. 4 (2016): 853–66. http://dx.doi.org/10.1017/s1366728916000535.

Full text

Abstract:

The study examined granularity of lexical partitioning of the blue area in speakers of English, which encodes the termblue; Russian, which encodes two terms, sinij[dark/navy blue] andgoluboj[light/sky blue]; and Ukrainian, which encodes the termssynij[dark/navy blue] andblakytnyjandgolubyj[light/sky blue]. Five groups of participants took part in the study: (1) 30 L1 speakers of English, (2) 30 L1 speakers of Russian, (3) 30 Russian–English bilinguals, (4) 30 English–Russian bilinguals, and (5) 25 Ukrainian–Russian–English trilinguals. Quantitative and qualitative analyses revealed that L1 Rus

APA, Harvard, Vancouver, ISO, and other styles

18

Öhlschläger, Peter, Wolfram Osen, Kerstin Dell, et al. "Human Papillomavirus Type 16 L1 Capsomeres Induce L1-Specific Cytotoxic T Lymphocytes and Tumor Regression in C57BL/6 Mice." Journal of Virology 77, no. 8 (2003): 4635–45. http://dx.doi.org/10.1128/jvi.77.8.4635-4645.2003.

Full text

Abstract:

ABSTRACT We analyzed capsomeres of human papillomavirus type 16 (HPV16) consisting of the L1 major structural protein for their ability to trigger a cytotoxic T-cell (CTL) response. To this end, we immunized C57BL/6 mice and used the L1165-173 peptide for ex vivo restimulation of splenocytes prior to analysis (51Cr release assay and enzyme-linked immunospot assay [ELISPOT]). This peptide was identified in this study as a Db-restricted naturally processed CTL epitope by HPV16 L1 sequence analysis, major histocompatibility complex class I binding, and 51Cr release assays following immunization o

APA, Harvard, Vancouver, ISO, and other styles

19

Gonçalves, Perpétua. "The role of ambiguity in second language change: the case of Mozambican African Portuguese." Second Language Research 18, no. 4 (2002): 325–47. http://dx.doi.org/10.1191/0267658302sr209oa.

Full text

Abstract:

In this article, my point of departure is that language change is driven by acquisition, and I argue that the triggers for establishing the properties of language-specific grammars differ according to whether first language (L1) or second language (L2) acquisition is involved. The reason for this is that in L2 acquisition evidence about the target grammar may be ambiguous in ways which do not occur in L1 acquisition. To illustrate the argument, I present two case studies of Mozambican African Portuguese, a nonnative variety of Portuguese acquired during childhood by L1 speakers of Bantu langua

APA, Harvard, Vancouver, ISO, and other styles

20

Chapellier, Marion, Evelina Martinenaite, Preeyam Patel, et al. "Abstract 4094: Immune modulatory cancer vaccines against IDO1 and PD-L1 trigger distinct pathways and cooperatively reduce tumor growth in preclinical models." Cancer Research 84, no. 6_Supplement (2024): 4094. http://dx.doi.org/10.1158/1538-7445.am2024-4094.

Full text

Abstract:

Abstract While immune checkpoint inhibitors have shown clinical efficacy in many cancers, drug and immune resistance remain challenging. Indoleamine 2,3-dehydrogenase (IDO1) and Programmed Death Ligand 1 (PD-L1) both contribute to immunosuppression, leading to immune escape and cancer progression. In this context, vaccination to promote T-cell immunity against IDO1+ and PD-L1+ cells is an attractive strategy that demonstrated encouraging clinical results in melanoma (Kjeldsen et al. Nat Med 2021). Our study aims to further evaluate the efficacy and mode of action of combined IDO1 and PD-L1 pep

APA, Harvard, Vancouver, ISO, and other styles

21

Kelsey, Maxfield M. G. "Reconsidering LINE-1’s role in cancer: does LINE-1 function as a reporter detecting early cancer-associated epigenetic signatures?" Evolution, Medicine, and Public Health 9, no. 1 (2021): 78–82. http://dx.doi.org/10.1093/emph/eoab004.

Full text

Abstract:

Abstract Long interspersed nuclear element-1 (LINE-1 or L1) is the only autonomously active retrotransposon in humans. While L1 has been implicated in several pathologies and the aging process, I present a model which challenges an understanding of L1 as predominantly antagonistic to human health. I hypothesize that L1 serves as a reporter in an early cancer alert system: a tripwire strung throughout the genome poised to trigger p53 and a type I interferon (IFN-1) response when the epigenetic landscape portends cancer. Cell proliferation and a shift to aerobic glycolysis cause dramatic changes

APA, Harvard, Vancouver, ISO, and other styles

22

Brooke, Jim, Karol Bunkowski, Ivan Cali, Carlos Ghabrous Larrea, Christos Lazaridis, and Alessandro Thea. "SWATCH: common control SW for the uTCA-based upgraded CMS L1 Trigger." Journal of Physics: Conference Series 664, no. 8 (2015): 082012. http://dx.doi.org/10.1088/1742-6596/664/8/082012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bortignon, P. "Design and performance of the upgrade of the CMS L1 muon trigger." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 824 (July 2016): 256–57. http://dx.doi.org/10.1016/j.nima.2015.11.065.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Bystricky, J., D. Calvet, P. Le Du, et al. "Algorithms and architecture for the L1 calorimeter trigger at D0 run IIb." IEEE Transactions on Nuclear Science 51, no. 3 (2004): 351–55. http://dx.doi.org/10.1109/tns.2004.828513.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Boss, Alan P., and Sandra A. Keiser. "WHO PULLED THE TRIGGER: A SUPERNOVA OR AN ASYMPTOTIC GIANT BRANCH STAR?" Astrophysical Journal 717, no. 1 (2010): L1—L5. http://dx.doi.org/10.1088/2041-8205/717/1/l1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Kuang, Dong-Ming, Qiyi Zhao, Chen Peng, et al. "Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1." Journal of Experimental Medicine 206, no. 6 (2009): 1327–37. http://dx.doi.org/10.1084/jem.20082173.

Full text

Abstract:

Macrophages (Mϕ) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironments. We have recently found that tumors can alter the normal developmental process of Mϕ to trigger transient activation of monocytes in peritumoral stroma. We showed that a fraction of monocytes/Mϕ in peritumoral stroma, but not in cancer nests, expresses surface PD-L1 (also termed B7-H1) molecules in tumors from patients with hepatocellular carcinoma (HCC). Monocytes activated by tumors strongly express PD-L1 proteins with kinetics similar to their activation status, and signi

APA, Harvard, Vancouver, ISO, and other styles

27

Yan, Lingyan, Yanan Sun, Jihua Guo, and Rong Jia. "PD-L1 Exon 3 Is a Hidden Switch of Its Expression and Function in Oral Cancer Cells." International Journal of Molecular Sciences 24, no. 9 (2023): 8193. http://dx.doi.org/10.3390/ijms24098193.

Full text

Abstract:

The interaction between programmed cell death 1 ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) protects tumor cells from immune surveillance. PD-L1 exon 3 is a potential alternative exon and encodes an Ig variable (IgV) domain. Here, we found that a lack of exon 3 leads to the significant loss of cellular membrane locations and the dramatically reduced protein expression of PD-L1, indicating that PD-L1 exon 3 is essential for its protein expression and translocation to the cell membrane. Notably, oral cancer cells show almost no exon 3 skipping to ensure the expression of the full

APA, Harvard, Vancouver, ISO, and other styles

28

Huang, Kevin Chih-Yang, Shu-Fen Chiang, William Tzu-Liang Chen, et al. "Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer." Cancers 12, no. 2 (2020): 462. http://dx.doi.org/10.3390/cancers12020462.

Full text

Abstract:

Programmed cell death-1 (PD-1) has demonstrated impressive clinical outcomes in several malignancies, but its therapeutic efficacy in the majority of colorectal cancers is still low. Therefore, methods to improve its therapeutic efficacy in colorectal cancer (CRC) patients need further investigation. Here, we demonstrate that immunogenic chemotherapeutic agents trigger the induction of tumor PD-L1 expression in vitro and in vivo, a fact which was validated in metastatic CRC patients who received preoperatively neoadjuvant chemotherapy (neoCT) treatment, suggesting that tumor PD-L1 upregulation

APA, Harvard, Vancouver, ISO, and other styles

29

Hou, Hanxi, Cheuk Wun Li, Yaron Tomer, Zhengzi Yi, Weijia Zhang, and Mihaela Stefan Lifshitz. "OR19-5 Dissecting Thyroidal Pathways Activated by PD-L1 Blockade Identifies New Mechanisms for Thyroiditis Triggered by Immune Checkpoint Inhibitors." Journal of the Endocrine Society 6, Supplement_1 (2022): A802. http://dx.doi.org/10.1210/jendso/bvac150.1660.

Full text

Abstract:

Abstract Programmed death-ligand 1 (PD-L1) is a strong immunosuppressor that inhibits T-cell activation by binding to its receptor (PD-1) on T-cells. Blocking the PD-L1/PD-1 interaction by monoclonal antibodies (mAbs) is an effective therapy for several cancers via activation of T-cells. Destructive thyroiditis and hypothyroidism often develop during anti-PD-L1 (αPD-L1) therapy but the pathogenic mechanisms are not known. We evaluated in vivo, the role of PD-L1 and its interactions with inflammatory triggers in the development of autoimmune thyroiditis (AIT). NOD.H-2h4 mice were treated with e

APA, Harvard, Vancouver, ISO, and other styles

30

Migliorini, M., J. Pazzini, A. Triossi, and M. Zanetti. "40 MHz triggerless readout of the CMS Drift Tube muon detector." Journal of Instrumentation 19, no. 02 (2024): C02050. http://dx.doi.org/10.1088/1748-0221/19/02/c02050.

Full text

Abstract:

Abstract The Level-1 trigger scouting system of the CMS experiment aims at intercepting the intermediate data produced by the L1 trigger processors before the final trigger decision. This system can be complemented by adding the raw stream of data collected from the detector front-end, whenever the throughput is manageable. In this work, the triggerless readout of the CMS Drift Tubes (DT) detector is presented. This is realized by reading a sector of the DT which has been equipped with the preproduction of Phase-2 upgrade front-end boards. A Xilinx VCU118 acts as a concentrator of the Phase-2

APA, Harvard, Vancouver, ISO, and other styles

31

Baur, Rebecca, Franziska Karl, Romy Böttcher-Loschinski, et al. "Accumulation of T-cell-suppressive PD-L1^highextracellular vesicles is associated with GvHD and might impact GvL efficacy." Journal for ImmunoTherapy of Cancer 11, no. 3 (2023): e006362. http://dx.doi.org/10.1136/jitc-2022-006362.

Full text

Abstract:

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for a number of hemato-oncological disorders. In fact, allo-HSCT is considered as one of the most successful immunotherapies as its clinical efficacy is based on the donor T-cells’ capacity to control residual disease. This process is known as the graft-versus-leukemia (GvL) reaction. However, alloreactive T-cells can also recognize the host as foreign and trigger a systemic potentially life-threatening inflammatory disorder termed graft-versus-host disease (GvHD). A better understandin

APA, Harvard, Vancouver, ISO, and other styles

32

Venturin, Beatrice. "“I Don’t Fit in Here and I Don’t Fit in There:” Understanding the Connections between L1 Attrition and Feelings of Identity in 1.5 Generation Russian Australians." Heritage Language Journal 16, no. 2 (2019): 238–68. http://dx.doi.org/10.46538/hlj.16.2.6.

Full text

Abstract:

The present study analyzes four adult Russian-Australian 1.5ers, heritage bilinguals whose first language is Russian, and who immigrated to Australia or New Zealand during their primary school years. Semi-structured interviews conducted with the case-study participants examined their attitudes toward their Russian, their L1, and English, their L2. The interviews explored the participants’ schooling history, language use, perceived language proficiency, dominance and use, perceived L1 attrition, and feelings about their identity. The aim of the study was to understand the connections between la

APA, Harvard, Vancouver, ISO, and other styles

33

Kciuk, Mateusz, Damian Kołat, Żaneta Kałuzińska-Kołat, et al. "PD-1/PD-L1 and DNA Damage Response in Cancer." Cells 12, no. 4 (2023): 530. http://dx.doi.org/10.3390/cells12040530.

Full text

Abstract:

The application of immunotherapy for cancer treatment is rapidly becoming more widespread. Immunotherapeutic agents are frequently combined with various types of treatments to obtain a more durable antitumor clinical response in patients who have developed resistance to monotherapy. Chemotherapeutic drugs that induce DNA damage and trigger DNA damage response (DDR) frequently induce an increase in the expression of the programmed death ligand-1 (PD-L1) that can be employed by cancer cells to avoid immune surveillance. PD-L1 exposed on cancer cells can in turn be targeted to re-establish the im

APA, Harvard, Vancouver, ISO, and other styles

34

Sahler, J. M., C. R. Eade, C. Altier, and J. C. March. "Salmonella entericaSerovar Typhimurium Increases Functional PD-L1 Synergistically with Gamma Interferon in Intestinal Epithelial Cells viaSalmonellaPathogenicity Island 2." Infection and Immunity 86, no. 5 (2018): e00674-17. http://dx.doi.org/10.1128/iai.00674-17.

Full text

Abstract:

ABSTRACTNontyphoidal serovars ofSalmonella entericaare pathogenic bacteria that are common causes of food poisoning. WhereasSalmonellamechanisms of host cell invasion, inflammation, and pathogenesis are mostly well established, a new possible mechanism of immune evasion is being uncovered. Programmed death ligand 1 (PD-L1) is an immunosuppressive membrane protein that binds to activated T cells via their PD-1 receptor and thereby halts their activation. PD-L1 expression plays an essential role in the immunological tolerance of self-antigens but is also exploited for immune evasion by pathogen-

APA, Harvard, Vancouver, ISO, and other styles

35

Bachtis, M., D. Campos, J. Jones, and M. Tepper. "The Octopus processor for the CMS L1 muon trigger for High Luminosity LHC." Journal of Instrumentation 17, no. 03 (2022): C03025. http://dx.doi.org/10.1088/1748-0221/17/03/c03025.

Full text

Abstract:

Abstract The upgraded L1 muon trigger system of the CMS experiment in the High Luminosity Large Hadron Collider is based on custom processors featuring large Field Programmable Gate Arrays (FPGAs) connected by large numbers of optical links. These provide the I/O bandwidth and power necessary to process the complex algorithms used during the collection of physics data. The design and performance requirements of these processors creates significant challenges in signal integrity, power delivery, and thermal management. In this paper we describe the Octopus processor, featuring a large Xilinx Vi

APA, Harvard, Vancouver, ISO, and other styles

36

Lanzolla, Giulia, Alberto Coppelli, Mirco Cosottini, Stefano Del Prato, Claudio Marcocci, and Isabella Lupi. "Immune Checkpoint Blockade Anti–PD-L1 as a Trigger for Autoimmune Polyendocrine Syndrome." Journal of the Endocrine Society 3, no. 2 (2019): 496–503. http://dx.doi.org/10.1210/js.2018-00366.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Schwegler, P., O. Kortner, H. Kroha, and R. Richter. "Improvement of the L1 trigger for the ATLAS muon spectrometer at high luminosity." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 718 (August 2013): 245–47. http://dx.doi.org/10.1016/j.nima.2013.01.023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Moreau, F. "The low noise L1 trigger of the H1 lead/scintillating-fibre electromagnetic calorimeter." Nuclear Physics B - Proceedings Supplements 61, no. 3 (1998): 132–36. http://dx.doi.org/10.1016/s0920-5632(97)00551-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Avgustinovich, Alexandra V., Olga V. Bakina, Sergey G. Afanas’ev, Liudmila V. Spirina, and Alexander M. Volkov. "Safety and Efficacy of Neoadjuvant Chemoimmunotherapy in Gastric Cancer Patients with a PD-L1 Positive Status: A Case Report." Current Issues in Molecular Biology 45, no. 9 (2023): 7642–49. http://dx.doi.org/10.3390/cimb45090481.

Full text

Abstract:

Introduction: The landscape of gastric cancer treatment has changed owing to the widespread use of immune checkpoint inhibitors. Autophagy, involved in regulating the immune system, is a potential trigger of immunity in tumors. This study aims to find molecular-based evidence for the effectiveness of FLOT chemotherapy with immune checkpoint inhibitors in gastric cancer patients. Materials and Methods: Three patients with advanced gastric cancer received FLOT neoadjuvant chemotherapy with immunotherapy and surgery. IHC was used to determine the PD-L1 status. Real-time PCR was used to analyze ex

APA, Harvard, Vancouver, ISO, and other styles

40

Hu, Lujun, Wenjie Chen, Shurong Zhou, and Guizhi Zhu. "ExoHCR: a sensitive assay to profile PD-L1 level on tumor exosomes for immunotherapeutic prognosis." Biophysics Reports 6, no. 6 (2020): 290–98. http://dx.doi.org/10.1007/s41048-020-00122-x.

Full text

Abstract:

AbstractCancer immunotherapy has made recent breakthrough, including immune checkpoint blockade (ICB) that inhibits immunosuppressive checkpoints such as programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1). However, most cancer patients do not durably respond to ICB. To predict ICB responses for patient stratification, conventional immunostaining has been used to analyze the PD-L1 expression level on biopsied tumor tissues but has limitations of invasiveness and tumor heterogeneity. Recently, PD-L1 levels on tumor cell exosomes showed the potential to predict ICB respo

APA, Harvard, Vancouver, ISO, and other styles

41

Adam, W., T. Bergauer, K. Damanakis, et al. "Beam test performance of a prototype module with Short Strip ASICs for the CMS HL-LHC tracker upgrade." Journal of Instrumentation 17, no. 06 (2022): P06039. http://dx.doi.org/10.1088/1748-0221/17/06/p06039.

Full text

Abstract:

Abstract The Short Strip ASIC (SSA) is one of the four front-end chips designed for the upgrade of the CMS Outer Tracker for the High Luminosity LHC. Together with the Macro-Pixel ASIC (MPA) it will instrument modules containing a strip and a macro-pixel sensor stacked on top of each other. The SSA provides both full readout of the strip hit information when triggered, and, together with the MPA, correlated clusters called stubs from the two sensors for use by the CMS Level-1 (L1) trigger system. Results from the first prototype module consisting of a sensor and two SSA chips are presented. Th

APA, Harvard, Vancouver, ISO, and other styles

42

Fedi, Giacomo. "L1 track trigger for the CMS HL-LHC upgrade using AM chips and FPGAs." EPJ Web of Conferences 150 (2017): 00004. http://dx.doi.org/10.1051/epjconf/201715000004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Klinz, Stephan G., Melitta Schachner, and Patricia F. Maness. "L1 and N-CAM Antibodies Trigger Protein Phosphatase Activity in Growth Cone-Enriched Membranes." Journal of Neurochemistry 65, no. 1 (2002): 84–95. http://dx.doi.org/10.1046/j.1471-4159.1995.65010084.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Tang, Tianyu, Xing Huang, Gang Zhang, et al. "Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis." Journal for ImmunoTherapy of Cancer 10, no. 3 (2022): e004129. http://dx.doi.org/10.1136/jitc-2021-004129.

Full text

Abstract:

BackgroundLTX-315 is an oncolytic peptide deriving from bovine lactoferrin, with the ability to induce cancer immunogenic cell death. However, the mechanism used by LTX-315 to trigger the antitumor immune response is still poorly understood. The expression of programmed cell death ligand 1 (PD-L1) largely determines the efficacy and effectiveness of cancer immunotherapies targeting this specific immune checkpoint. This study aimed to demonstrate the potential effect and mechanism of LTX-315 in PD-L1 inhibition-induced anti-pancreatic cancer immunity.MethodsBoth immunodeficient and immunocompet

APA, Harvard, Vancouver, ISO, and other styles

45

Tanaka, Ryota, Yuki Ichimura, Manabu Fujimoto, and Naoko Okiyama. "Distinct roles of programmed cell death ligands 1 and 2, based on the type of immunity." Journal of Immunology 204, no. 1_Supplement (2020): 229.7. http://dx.doi.org/10.4049/jimmunol.204.supp.229.7.

Full text

Abstract:

Abstract Programmed cell death-1 (PD-1) is an immuno-regulatory receptor binding to two ligands, PD-L1 and PD-L2, which are expressed on stimulated antigen presenting cells (APCs). Isolated APCs such as macrophages (Mϕ), dendritic cells (DC), and B cells were cultured with interferon (IFN)-γ, interleukin (IL)-4, and IL-17A, respectively, followed by PD-L1/L2 expression analysis using flow cytometry. Upon stimulation by IFN-γ on all APCs and IL-17A on Mϕ and B cells, respectively, strong and moderate upregulation of PD-L1 expression was observed over unstimulated controls. Only stimulation by I

APA, Harvard, Vancouver, ISO, and other styles

46

Musial, Shawn C., Tyler G. Searles, Sierra A. Kleist, et al. "Brain resident memory CD8+ T cells trigger CNS immune activation and infiltration." Journal of Immunology 208, no. 1_Supplement (2022): 165.18. http://dx.doi.org/10.4049/jimmunol.208.supp.165.18.

Full text

Abstract:

Abstract The shifting paradigm regarding immune surveillance of the central nervous system (CNS) has shed light on immune cell networks thought to be absent from healthy brain tissue. Resident memory T cells (TRM) are a unique subset of memory T cells that persist within non-lymphoid tissues to provide rapid onset protection against reinfection. Recently, brain TRM (bTRM) have been identified in humans, with CNS or peripheral infection, or vaccination leading to bTRM establishment in mice. While bTRM are important for protection of the CNS against reinfection, their regulation and involvement

APA, Harvard, Vancouver, ISO, and other styles

47

Ban, Masao, Konosuke Kawashima, Kae Tsunematsu, Takumi Imura, Kyoko S. Kataoka, and Tohru Yamanoi. "Geologic and Petrologic Characteristics of the Lahar Deposits at the Western Foot of Zao Volcano." Journal of Disaster Research 17, no. 5 (2022): 736–44. http://dx.doi.org/10.20965/jdr.2022.p0736.

Full text

Abstract:

The lahars are one of the most hazardous volcanic phenomena causing the third greatest causalities among the volcanic hazards since the 16th century worldwide. Lahars can flow down a long distance and cause tremendous disaster at the foot of volcanoes often beyond the areas of primary volcanic impacts of pyroclastic fall and pyroclastic density currents. Therefore, the research on lahar history of active volcanoes approaching from an analysis of a geological record in distal volcanic regions is significant for lahar hazard risk evaluation. Zao volcano has high risks of future eruptions, becaus

APA, Harvard, Vancouver, ISO, and other styles

48

Bajor, Malgorzata, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, et al. "PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells." Journal for ImmunoTherapy of Cancer 10, no. 1 (2022): e002500. http://dx.doi.org/10.1136/jitc-2021-002500.

Full text

Abstract:

BackgroundImmune checkpoint inhibitors and chimeric antigen receptor (CAR)-based therapies have transformed cancer treatment. Recently, combining these approaches into a strategy of PD-L1-targeted CAR has been proposed to target PD-L1high tumors. Our study provides new information on the efficacy of such an approach against PD-L1low targets.MethodsNew atezolizumab-based PD-L1-targeted CAR was generated and introduced into T, NK, or NK-92 cells. Breast cancer MDA-MB-231 and MCF-7 cell lines or non-malignant cells (HEK293T, HMEC, MCF-10A, or BM-MSC) were used as targets to assess the reactivity

APA, Harvard, Vancouver, ISO, and other styles

49

Mu, Wei, Lei Jiang, Yu Shi, et al. "Non-invasive measurement of PD-L1 status and prediction of immunotherapy response using deep learning of PET/CT images." Journal for ImmunoTherapy of Cancer 9, no. 6 (2021): e002118. http://dx.doi.org/10.1136/jitc-2020-002118.

Full text

Abstract:

BackgroundCurrently, only a fraction of patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) experience a durable clinical benefit (DCB). According to NCCN guidelines, Programmed death-ligand 1 (PD-L1) expression status determined by immunohistochemistry (IHC) of biopsies is the only clinically approved companion biomarker to trigger the use of ICI therapy. Based on prior work showing a relationship between quantitative imaging and gene expression, we hypothesize that quantitative imaging (radiomics) can provide an alternative surrogate for PD-L1 ex

APA, Harvard, Vancouver, ISO, and other styles

50

Brandel, Noa. "The positive effect of explicit positive evidence." Instructed Second Language Acquisition 2, no. 2 (2018): 215–41. http://dx.doi.org/10.1558/isla.35105.

Full text

Abstract:

The study investigates questions central to the field of second language (L2) acquisition and instruction: Does the first language (L1) influence the L2 grammar? Can wrong patterns be restructured? Is Universal Grammar accessible during L2 acquisition? And can L2 acquisition, rather than learning (in Krashen’s sense), be triggered by explicit positive evidence (EPE), combining input flood with explicit emphasis upon target forms? Three properties associated with the Null Subject Parameter were inspected in two sixth-grade groups (L1-Hebrew, L2-English): thematic subject omission, expletive sub

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!