Relevant bibliographies by topics / La Aurora

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'La Aurora'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "La Aurora"

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Titova, E. E., A. G. Yahnin, O. Santolík, D. A. Gurnett, F. Jirícek, J. L. Rauch, F. Lefeuvre, L. A. Frank, J. B. Sigwarth, and M. M. Mogilevsky. "The relationship between auroral hiss at high altitudes over the polar caps and the substorm dynamics of aurora." Annales Geophysicae 23, no. 6 (September 15, 2005): 2117–28. http://dx.doi.org/10.5194/angeo-23-2117-2005.

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Abstract. Strong variations of intensity and cutoff frequency of the auroral hiss were observed by INTERBALL-2 and POLAR satellites at high altitudes, poleward from the auroral oval. The hiss intensifications are correlated with the auroral activations during substorms and/or pseudo-breakups. The low cutoff frequency of auroral hiss increases with the distance between the aurora and the satellite footprint. Multicomponent wave measurements of the hiss emissions on board the POLAR spacecraft show that the horizontal component of the Poynting flux of auroral hiss changes its direction in good accordance with longitudinal displacements of the bright auroras. The vertical component of the Poynting flux is directed upward from the aurora region, indicating that hiss could be generated by upgoing electron beams. This relationship between hiss and the aurora dynamics means that the upgoing electron beams are closely related to downgoing electron beams which produce the aurora. During the auroral activations the upgoing and downgoing beams move and change their intensities simultaneously. Keywords. Magnetospheric physics (Auroral phenomena; Plasma waves and instabilities; Storms and substorms)
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Grono, Eric, and Eric Donovan. "Surveying pulsating auroras." Annales Geophysicae 38, no. 1 (January 2, 2020): 1–8. http://dx.doi.org/10.5194/angeo-38-1-2020.

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Abstract. The early-morning auroral oval is dominated by pulsating auroras. These auroras have often been discussed as if they are one phenomenon, but they are not. Pulsating auroras are separable based on the extent of their pulsation and structuring into at least three subcategories. This study surveyed 10 years of all-sky camera data to determine the occurrence probability for each type of pulsating aurora in magnetic local time and magnetic latitude. Amorphous pulsating aurora (APAs) are a pervasive, nearly daily feature in the early-morning auroral oval which have an 86 % chance of occurrence at their peak. Patchy pulsating auroras (PPAs) and patchy auroras (PAs) are less common, peaking at 21 % and 29 %, respectively. Before local midnight, pulsating auroras are almost exclusively APAs. Occurrence distributions of APAs, PPAs, and PAs are mapped into the equatorial plane to approximately locate their source regions. The PA and PPA distributions primarily map to locations approximately between 4 and 9 RE, while some APAs map to farther distances, suggesting that the mechanism which structures PPAs and PAs is constrained to the inner magnetosphere. This is in agreement with Grono and Donovan (2019), which located these auroras relative to the proton aurora.
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Miyashita, Yukinaga, and Akimasa Ieda. "Revisiting substorm events with preonset aurora." Annales Geophysicae 36, no. 5 (October 19, 2018): 1419–38. http://dx.doi.org/10.5194/angeo-36-1419-2018.

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Abstract. Nishimura et al. (2010) proposed a new plasma intrusion or preonset aurora scenario of substorm triggering. In this scenario, a substorm is triggered by a fast earthward flow generated at the distant neutral line which corresponds to a preonset auroral streamer or arc in the ionosphere propagating from the auroral poleward boundary to the initial auroral brightening site, i.e., “preonset aurora”. In the present paper, we revisited three substorm events reported as being triggered by such a mechanism related to preonset auroras, based on THEMIS ground-based all-sky imager data. Unlike previous studies, we examined the arrival timing of the preonset aurora relative to the three steps of auroral onset arc development (initial brightening, enhancement of the wave-like structure, and poleward expansion) to make the role of the preonset aurora in the auroral steps clearer. Our detailed timing analysis found that preonset auroral streamers reached the auroral onset arc but away from the initial brightening site after initial brightening for two events, while no preonset aurora reaching the initial brightening site could be identified for the other event. This result suggests that the processes associated with auroral streamers are unlikely to affect at least initial brightening, even if we consider not only the presence and arrival timing and location of the auroral streamers but also the scale of the corresponding flow and flow vortices. We list a series of open questions for testing the preonset aurora scenario further in future studies. Keywords. Magnetospheric physics (storms and substorms; auroral phenomena; magnetotail)
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He, Fei, Yong Wei, and Weixing Wan. "Equatorial aurora: the aurora-like airglow in the negative magnetic anomaly." National Science Review 7, no. 10 (April 24, 2020): 1606–15. http://dx.doi.org/10.1093/nsr/nwaa083.

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Abstract The most fantastic optical phenomena in the Earth's upper atmosphere are the auroras. They are highly informative indicators of solar activity, geomagnetic activity, upper atmospheric structures and dynamics, and magnetospheric energetic particles. An area where the geomagnetic field differs significantly from the expected symmetric dipole, such as at the South Atlantic Anomaly, where the magnetic field intensity is low, gives rise to stronger precipitation of energetic particles into the upper atmosphere. Impact excitation and the subsequent airglow emissions exhibit aurora-like dynamic signatures. Nomenclatures of nonpolar aurora or equatorial auroras are similar to those used with the polar auroras owing to their similar excitation mechanisms. This paper provides an overview of the knowledge and the challenges concerning auroral activity at the South Atlantic Anomaly, or more generally, at the negative magnetic anomaly. We emphasize systematic investigation of the equatorial auroras to reveal the temporal and spatial evolution of the magnetic anomaly and the behaviour of energetic particles in near-Earth space.
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Sandholt, P. E., and C. J. Farrugia. "Monitoring magnetosheath-magnetosphere interconnection topology from the aurora." Annales Geophysicae 20, no. 5 (May 31, 2002): 629–37. http://dx.doi.org/10.5194/angeo-20-629-2002.

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Abstract. A strong southward rotation of the IMF (BZ from 5 to -6 nT in ~ 20 s) on 4 January 1995 caused an abrupt reconfiguration of midday aurorae and plasma convection consisting of the following: (1) the red-line aurora associated with magnetosheath plasma transfer at the low-latitude magnetopause appeared at the same time that (2) the green-line aurora from precipitating energetic plasma sheet particles equatorward of the cusp (near the open-closed field line boundary) weakened visibly and shifted equatorward, (3) the high-latitude aurora during the previous northward IMF, which is associated with lobe reconnection, persisted briefly (3 min) and brightened, before it disappeared from the field-of-view, (4) the activation of a strong convection bay (DPY current) at cusp and sub-cusp latitudes when the field turned strongly south, (5) a distinct wave motion of the plasma sheet outer boundary, as inferred from the aurora, which correlates closely with Pc 5 magnetic pulsations. Our interpretation of the dramatic reconfiguration is that reconnection poleward of the cusp coexisted briefly with reconnection at sub-cusp latitudes. The latter provided a magnetic field connection which enabled, on the one hand, magnetosheath particles to enter and cause the red-line cusp aurora, and on the other hand, allowed for magnetospheric energetic particles to escape and weaken the outer plasma sheet source of the green-line emission. The coexistence of the two cusp auroras reflects the time required for one field line topology to replace another, which, under the prevailing high speed wind ( ~ 650 km/s), lasts ~ 3–4 min. The motion of open flux tubes propagating from equator to pole during this transition is traced in the aurora by a poleward moving form. The waves on the outer boundary of the plasma sheet are most likely due to the Kelvin-Helmholtz instability. The study illustrates the ability of local auroral observations to monitor even a global change in magnetospheric magnetic topology.Key words. Magnetospheric Physics (auroral phenomena; magnetopause, cusp, and boundary layers; solar wind-magnethoshere interactions)
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Hayakawa, Hisashi, José M. Vaquero, and Yusuke Ebihara. "Sporadic auroras near the geomagnetic equator: in the Philippines, on 27 October 1856." Annales Geophysicae 36, no. 4 (August 29, 2018): 1153–60. http://dx.doi.org/10.5194/angeo-36-1153-2018.

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Abstract. While low-latitude auroral displays are normally considered to be a manifestation of magnetic storms of considerable size, Silverman (2003, JGR, 108, A4) reported numerous “sporadic auroras” which appear locally at relatively low magnetic latitude during times of just moderate magnetic activity. Here, a case study is presented of an aurora near the geomagnetic equator based on a report from the Philippine islands on 27 October 1856. An analysis of this report shows it to be consistent with the known cases of sporadic auroras, except for its appearance at considerably low magnetic latitude. The record also suggests that an extremely low-latitude aurora is not always accompanied by large magnetic storms. The description of its brief appearance leads to a possible physical explanation based on an ephemeral magnetospheric disturbance provoking this sporadic aurora.
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Kataoka, Ryuho, Shiori Uchino, Yasunori Fujiwara, Shigeru Fujita, and Kazuaki Yamamoto. "Fan-shaped aurora as seen from Japan during a great magnetic storm on February 11, 1958." Journal of Space Weather and Space Climate 9 (2019): A16. http://dx.doi.org/10.1051/swsc/2019013.

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During a great magnetic storm on Feb 11, 1958, a fan-shaped aurora was photographed at Memambetsu, Hokkaido, Japan – the first and oldest photograph record of auroras observed in Japan, accompanied by many hand-made drawings, thus, portraying a rare opportunity of coexistence between photograph images and hand-made drawings. In fact, the same portrayal reminds us of the great red aurora with fan-shaped white pillars observed during the 1872 and 1770 great magnetic storms. The hand-made sketches, photographs, and the spectral data revealed that the white pillars and red glow of the fan-shaped aurora were dominated by auroral green and red lines, respectively. From the analysis of newly digitized microfilm data and hand-made drawings, we found that the fan-shaped aurora appeared during the peak activity of magnetic storm and moved westward at 0.4 km/s at 400-km altitude at 38°–40° magnetic latitudes, which is consistent with the enhanced convection pattern in the middle latitude at storm time. Such a fan-shaped aurora can fundamentally characterize the middle-latitude evening-to-midnight auroras during great magnetic storms, which show the most destabilized transient appearance of the inner magnetosphere.
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Blomberg, L. G., J. A. Cumnock, I. I. Alexeev, E. S. Belenkaya, S. Yu Bobrovnikov, and V. V. Kalegaev. "Transpolar aurora: time evolution, associated convection patterns, and a possible cause." Annales Geophysicae 23, no. 5 (July 28, 2005): 1917–30. http://dx.doi.org/10.5194/angeo-23-1917-2005.

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Abstract. We present two event studies illustrating the detailed relationships between plasma convection, field-aligned currents, and polar auroral emissions, as well as illustrating the influence of the Interplanetary Magnetic Field's y-component on theta aurora development. The transpolar arc of the theta aurorae moves across the entire polar region and becomes part of the opposite side of the auroral oval. Electric and magnetic field and precipitating particle data are provided by DMSP, while the POLAR UVI instrument provides measurements of auroral emissions. Ionospheric electrostatic potential patterns are calculated at different times during the evolution of the theta aurora using the KTH model. These model patterns are compared to the convection predicted by mapping the magnetopause electric field to the ionosphere using the Paraboloid Model of the magnetosphere. The model predicts that parallel electric fields are set up along the magnetic field lines projecting to the transpolar aurora. Their possible role in the acceleration of the auroral electrons is discussed. Keywords. Ionosphere (Plasma convection; Polar ionosphere) – Magnetospheric physics (Magnetosphereionosphere interactions)
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Maden, Nafiz. "Historical aurora borealis catalog for Anatolia and Constantinople (hABcAC) during the Eastern Roman Empire period: implications for past solar activity." Annales Geophysicae 38, no. 4 (July 28, 2020): 889–99. http://dx.doi.org/10.5194/angeo-38-889-2020.

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Abstract. Herein, Anatolian aurorae are reviewed based on the existing catalogs to establish a relationship between the aurora observations and past solar activity during the Medieval period. For this purpose, historical aurora catalogs for Constantinople and Anatolia are compiled based on the existing catalogs and compared with those in the Middle East region. The available catalogs in the literature are mostly related to the records observed in Europe, Japan, China, Russia, and the Middle East. There is no study dealing only with the historical aurora observations recorded in Anatolia and Constantinople. The data of the catalog show that there is a considerable relationship between the aurora activity and past strong solar activity. High auroral activity around the extreme solar particle storm in 774/775 and the Medieval grand maximum in the 1100s in Anatolia and the Middle East is quite consistent with the past solar variability reported in other scientific literature.
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Blixt, E. M., M. J. Kosch, and J. Semeter. "Relative drift between black aurora and the ionospheric plasma." Annales Geophysicae 23, no. 5 (July 27, 2005): 1611–21. http://dx.doi.org/10.5194/angeo-23-1611-2005.

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Abstract. Black auroras are recognized as spatially well-defined regions within uniform diffuse aurora where the optical emission is significantly reduced. Although a well studied phenomenon, there is no generally accepted theory for black auroras. One theory suggests that black regions are formed when energetic magnetospheric electrons no longer have access to the loss cone. If this blocking mechanism drifts with the source electron population in the magnetosphere, black auroras in the ionosphere should drift eastward with a velocity that increases with the energy of the precipitating electrons in the surrounding aurora, since the gradient-B curvature drift is energy dependent. It is the purpose of this paper to test this hypothesis. To do so we have used simultaneous measurements by the European Incoherent Scatter (EISCAT) radar and an auroral TV camera at Tromsø, Norway. We have analyzed 8 periods in which a black aurora occurred frequently to determine their relative drift with respect to the ionospheric plasma. The black aurora was found to drift eastward with a velocity of 1.5–4km/s, which is in accordance with earlier observations. However, one case was found where a black patch was moving westward, this being the first report of such behaviour in the literature. In general, the drift was parallel to the ionospheric flow but at a much higher velocity. This suggests that the generating mechanism is not of ionospheric origin. The characteristic energy of the precipitating electron population was estimated through inversion of E-region plasma density profiles. We show that the drift speed of the black patches increased with the energy of the precipitating electrons in a way consistent with the gradient-B curvature drift, suggesting a magnetospheric mechanism for the black aurora. As expected, a comparison of the drift speeds with a rudimentary dipole field model of the gradient-B curvature drift speed only yields order-of-magnitude agreement, which most likely is due to the nightside disturbed magnetosphere being significantly stretched. Keywords. Auroral ionosphere; MI interaction; Energetic particles, precipitating
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Dissertations / Theses on the topic "La Aurora"

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Höök, Josef. "Multispectral auroral imager and optical flow in aurora." Thesis, KTH, Rymd- och plasmafysik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-91893.

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”Auroral Structure and Kinetics” (ASK) is a multispectral auroral imager,developed and built by University of Southampton, UK, and Royal Institute ofTechnology, Sweden. The scientific objective of the instrument include characterisationof both high and low energy electron precipitation in aurora with highspatial and temporal resolution, and direct observation of plasma drifts in theionosphere. ASK consists of three cameras taking images in different spectrallines. One part of this thesis deals with the development of the data acquisitionsystem for the instrument. This included the hardware part (computers controllingthe cameras)and the software for operation of ASK. ASK was installedon Svalbard in November 2005, and examples of first data are presented. Thesecond part of the thesis treats the problem of estimation of motions from theauroral sequences. Robust optical flow estimation algorithm has been applied toauroral sequences, and new formulations specific to the imaging of metastableions (carried out by ASK) are suggested.
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Álvarez, García Daniel, Salazar Enrique Alberto Cebreros, Ludeña Yenifer Carolina Herrera, Vásquez María Angélica Herrera, and Monrroy Mariafe Jazmín Sayas. "Proyecto Aurora." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/655422.

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En el presente trabajo de investigación se analizan todos los aspectos necesarios para iniciar un proyecto de negocio basado en la elaboración y comercialización de productos de cuidado personal hechos a base de algas pardas, mayormente conocido como sargazo. Este insumo brinda colágeno, hidrata y contiene vitaminas beneficiosas para la piel, por lo que es adecuado recibir sus nutrientes a través de productos de uso rutinario. Actualmente, el mercado de productos de higiene y cuidado personal se encuentra en crecimiento por la situación actual de la pandemia del COVID-19, por lo que la población ha priorizado el consumo de productos que le aseguren limpieza y cuidado. Adicionalmente, ya existía una tendencia a utilizar productos que contengan insumos naturales para el cuidado de la piel, por lo que un negocio con estas características tiene valor agregado frente a las otras empresas del mercado actual en Perú. A partir de las situaciones planteadas nace Aurora, negocio de productos de cuidado personal hechos a base de algas pardas en presentación de jabón y crema hidratante. Aurora cubre las necesidades de este tipo de productos de los usuarios de nivel socioeconómico A/B y C de las zonas 6 y 7 de Lima Metropolitana. Se estima que su tamaño de mercado inicialmente es de 432 649 personas, con un crecimiento anual del 6%. Para el inicio de sus operaciones se necesita una inversión inicial de S/ 14 869,26, la cual le permitirá adquirir los recursos necesarios para la producción y comercialización del producto.
This research work analyzes all the necessary aspects to start a business project based on the development and commercialization of personal care products made from brown algae, mostly known as sargassum. This input provides collagen, hydrates and contains beneficial vitamins for the skin, so it is appropriate to receive its nutrients through products for routine use. Currently, the market for hygiene and personal care products is growing due to the current situation of the COVID-19 pandemic, so the population has prioritized the consumption of products that ensure cleanliness and care. Additionally, there was already a tendency to use products that contain natural ingredients for skin care, so a business with these characteristics has added value compared to other companies in the current market in Peru. From the situations raised, Aurora was born, a business of personal care products made from brown algae in a presentation of soap and moisturizer. Aurora covers the needs of this type of product for users of socioeconomic levels A / B and C in zones 6 and 7 of Metropolitan Lima. It is estimated that its market size initially is 432 649 people, with an annual growth of 6%. An initial investment of S / 14,869.26 is required to start its operations, which will allow it to acquire the necessary resources for the production and commercialization of the product.
Trabajo de investigación
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Ireland, Ryan Patrick. "Beyond Aurora." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1308585211.

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Mu, Jun. "VHF radar aurora, statistics, fading and correlation with optical aurora." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24039.pdf.

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Poynton, Michelle Bella D. "The Aurora project." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4724.

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Gil, Sánchez Jorge Luis, and Cavero Iván Artemio Janqui. "Proyecto Multifamiliar Aurora." Master's thesis, Pontificia Universidad Católica del Perú, 2018. http://hdl.handle.net/20.500.12404/14372.

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La presente tesis desarrolla el estudio de mercado y la propuesta de producto para un edificio multifamiliar ubicado en el Distrito de Miraflores, en una de las zonas mejor valoradas de Lima para uso residencial. Durante el periodo 2017-2018 se ha producido una reactivación del mercado inmobiliario frente al cual nuestro proyecto se busca posicionar como una opción de calidad y al mismo tiempo de una baja relación costo-beneficio en relación a los productos de la competencia dentro de este sector denominado Lima Top. Este sector siempre presenta una demanda estable, que durante el último periodo se ha incrementado en un 25% y además ha madurado en cuanto a su elección en la compra de inmuebles. Entre los atributos de nuestros productos, entregamos al cliente una alta calidad en el diseño acorde a las exigencias de este sector y dentro de la propuesta de diseño, la flexibilidad de la distribución la cual permite obtener productos con menores precios, igual equipamiento y mismo número de ambientes. Con estas características y considerando los precios de venta, costo de construcción y velocidad de ventas estimadas en la zona, consideramos nuestro proyecto como una oportunidad de negocio rentable y de mejora al urbanismo de la zona. Para lograr este propósito, se hace un estudio situacional a nivel económico social del país y la región, para identificar amenazas y oportunidades en el macroentorno. Luego en el estudio de mercado se muestran las características de la competencia en cuanto al detalle de sus diseños, sus precios y sus velocidades de venta, a fin de conocer que es lo que más valora la demanda de este sector. Luego de conocer estas preferencias, se realiza el diseño y cabida preliminar del producto, basado en las restricciones urbanísticas y de mercado de la zona. En esta etapa se encuentra un factor de costo de terreno vs venta adecuada. En ese sentido el producto resultante consiste en un proyecto de 10 departamentos: 8 flats del primer al cuarto nivel; y 2 dúplex ubicados en el quinto nivel y azotea. Se cuenta con 10 depósitos y 33 estacionamientos ubicados en el semisótano, sótano 1 y sótano 2. En los flats del primer piso, se ha generado una sala de reunión ubicada en el semisótano y en los pisos ubicados entre el primer, segundo, tercero y cuarto nivel, se ha propuesto la posibilidad de convertir el walking closet del dormitorio principal en un tercer dormitorio para la vivienda. Basado en la valoración de nuestra competencia encontramos una oportunidad de ingresar a través del posicionamiento de un producto con una baja relación costo-beneficio, lo cual es y transmitido al cliente mediante nuestro marketing mix como el hecho que nuestros precios de venta totales son menores en un 30% en un departamento con igual equipamiento en menor área construida y mejor distribución. Una vez definido el producto y la forma de ingresarlo al mercado, procedemos a realizar el análisis económico y financiero en la cual el escenario base, considera una velocidad de venta promedio estimada de una (1) unidad por mes. Sometido a distintas condiciones mediante el análisis de sensibilidad, el proyecto resulta con un VAN positivo hasta una variación de velocidad de venta hasta 0.4 unidades por mes y el costo de construcción puede subir hasta un máximo de 32.16% para resultar con un VAN positivo. Y respecto al flujo financiero del proyecto, resulta un VAN financiero mayor al VAN del flujo de caja operativo, lo que demuestra que la gestión financiera está agregando valor al proyecto. Bajo la gestión del proyecto y los cambios en las variables más incidentes en el escenario más pesimista, el proyecto nos resulta con un VAN positivo, lo que demuestra que el proyecto agregará valor al inversionista de manera segura.
Tesis
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Alcócer, Gamarra Alex, Ostolaza Sandra Ascenzo, Ingunza Rodolfo Mendoza, Mendoza Carola Pacheco, and Guerra Marietta Ramírez. "Edificio Multifamiliar: Aurora I." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273964.

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El presente estudio tiene la finalidad de determinar la rentabilidad de nuestro tercer proyecto inmobiliario, el Multifamiliar Aurora I, ubicado en el distrito de Miraflores, en la esquina de la calle García Gastañeta y la Avenida Villarán La primera parte del estudio permite determinar el Estado de Pérdidas y Ganancias estimado del proyecto inmobiliario; para la elaboración de este reporte se ha realizado un estudio técnico del costo de inversión en todas sus etapas, así como un estudio de la oferta existente en la zona La segunda parte del estudio consistirá en elaborar el Análisis Financiero, determinando la viabilidad y rentabilidad del proyecto y las alternativas de financiamiento Así mismo, se elaborará un Plan de Marketing basado en el estudio de mercado y el análisis del sector, para asegurar de esta manera la venta de los departamentos en los plazos requeridos
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Santos, Edmilson Ozorio dos. "Investigação das quinases Aurora A e Aurora B na tumorigenicidade mediada pelo oncogene KRAS." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-21062017-103949/.

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O câncer de pulmão é a principal causa de morte relacionada ao câncer no mundo. Mutações em KRAS são altamente prevalentes no câncer e têm sido diretamente associadas ao processo tumorigênico. Apesar disso, até hoje todas as terapias visando inibir KRAS diretamente falharam e a caracterização de alvos indiretos, importantes para a oncogênese mediada por KRAS, é fundamental para o desenvolvimento de novas terapias contra o câncer de pulmão. Nós mostramos previamente que as quinases Aurora A (AURKA) e B (AURKB) são alvos a jusante de KRAS, importantes para o crescimento, viabilidade e oncogenicidade de linhagens celulares derivadas de tumores pulmonares mediados por KRAS. Aqui, nós aprofundamos os nossos estudos para melhor caracterizar AURKA e AURKB como potenciais alvos terapêuticos no câncer de pulmão. Os objetivos deste trabalho foram (1) investigar o mecanismo de perda de viabilidade induzido pela inibição de AURKA e/ou AURKB; (2) avaliar como a inibição de AURKA e/ou AURKB afeta propriedades oncogênicas relacionadas à agressividade tumoral; e (3) como a inibição destas quinases afeta o crescimento tumoral in vivo. Para tanto, nós utilizamos dois modelos celulares: (1) células A549 e H358, que apresentam mutações em KRAS, geneticamente modificadas para a expressão estável e induzível de shRNAs contra AURKA ou AURKB, e (2) células tumorais H1703, que não apresentam mutações em KRAS, geneticamente modificadas para a expressão induzível de KRASG12V, tratadas ou não com inibidores farmacológicos das quinases Aurora. A inibição farmacológica ou por interferência de RNA de AURKA e/ou AURKB em células H358 e A549 reduziu a proliferação celular, sendo esta inibição acompanhada de anomalias mitóticas, além de aneuploidia e poliploidia. A inibição destas quinases também induziu morte celular in vitro, tanto em mitose, quanto em interfase. Mais interessantemente, a inibição farmacológica dual de AURKA e AURKB induziu morte celular in vitro em células H1703, somente na presença de KRASG12V, indicando que a inibição das quinases Aurora afeta preferencialmente células portadoras de mutações em KRAS. Além disso, a inibição de AURKA e/ou AURKB reduziu propriedades malignas celulares relacionadas à agressividade tumoral, como migração, invasão e adesão. Finalmente, a inibição de AURKA por RNA de interferência em células A549 também reduziu a formação de tumores in vivo. Entretanto, como a inibição destas quinases levou a anomalias mitóticas e à instabilidade genética, nós resolvemos investigar se a inibição de TPX2, um substrato e ativador de AURKA, poderia ser uma abordagem alternativa para inibir esta via em câncer de pulmão induzido por KRAS. Primeiramente, nós observamos nos nossos modelos celulares que KRAS regula positivamente a expressão de TPX2. Além disso, a inibição de TPX2 em células pulmonares portadoras de KRAS oncogênica reduziu a viabilidade e proliferação celulares e induziu morte celular. Mais interessantemente, esses efeitos ocorreram preferencialmente em células que expressam KRAS oncogênica. Em conclusão, nossos resultados apoiam a hipótese de que a ativação de AURKA/TPX2 e AURKB por KRAS são eventos importantes no câncer de pulmão e sugerem a inibição destas vias, possivelmente em combinação com outras terapias citotóxicas, como uma nova abordagem terapêutica para o câncer de pulmão induzido por KRAS.
Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS mutations are widespread in lung cancer and have been causally linked to tumorigenesis. Nonetheless, therapies targeting KRAS directly have so far failed and characterization of indirect KRAS targets, which play important roles in KRAS-mediated oncogenesis, is crucial for the development of new therapies for lung cancer. We have previously shown that mitotic kinases Aurora A (AURKA) and B (AURKB) are downstream targets of oncogenic KRAS, important for the growth, viability, and oncogenicity of KRAS-transformed lung cancer cell lines. Here, we studied these kinases more in depth in order to better characterize them as potential therapeutical targets for KRAS-induced lung cancer. The aims of this study were (1) to investigate the mechanism leading to loss of viability upon AURKA and/or AURKB targeting; (2) to evaluate how AURKA and/or AURKB inhibition affects malignant properties associated with tumor aggressiveness; and (3) to determine whether AURKA and/or AURKB inhibition reduces KRAS-induced tumor growth in vivo. For that purpose, we used two cell-based models: (1) KRAS mutant A549 and H358 cells with stable and inducible shRNA-mediated knockdown of AURKA or AURKB, and (2) KRAS wildtype H1703 tumor cell lines, genetically engineered to inducibly express oncogenic KRASG12V treated or not with Aurora kinase pharmacological inhibitors. Targeting AURKA and/or AURKB pharmacologically or by RNA interference in H358 and A549 cells led to decreased cell proliferation, which was accompanied by mitotic abnormalities, leading to aneuploidy and hyperploidy. Aurora kinase targeting also induced cell death in vitro, both during mitosis and interphase. More importantly, AURKA and AURKB inhibition with a dual pharmacological inhibitor in H1703 cells induced cell death in vitro, but only in the presence of KRASG12V, indicating that Aurora kinase targeting affects preferentially lung cells harboring oncogenic KRAS. Furthermore, AURKA and/or AURKB targeting reduced malignant properties associated with tumor aggressiveness, such as cell migration, invasion and adhesion. Finally, AURKA targeting by RNA interference in A549 cells also reduced growth of xenograft tumors in vivo. Nonetheless, since Aurora targeting was associated with mitotic abnormalities and genetic instability, we decided to investigate if targeting TPX2, a substrate and an activator of AURKA, could constitute an alternative approach to targeting this pathway in KRAS-induced lung cancer. First, using our cell-based models, we determined that KRAS positively regulates TPX2 expression. In addition, TPX2 inhibition by RNA interference in KRAS-positive lung cells reduced cell viability and proliferation and induced cell death. Finally, these effects occurred preferentially in cells harboring oncogenic KRAS. In conclusion, our results support the hypothesis that activation of AURKA/TPX2 and AURKB by KRAS are important events in lung cancer and suggest inhibition of these pathways, possibly in combination with other cytotoxic therapies, as a new approach for KRAS-induced lung cancer therapy.
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9

Coe, Godfrey. "Radar studies of the aurora." Thesis, University of Leicester, 1985. http://hdl.handle.net/2381/35859.

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The investigation of the high-latitude aurora by means of the V.H.F. auroral radar SABRE, (Swedish And British auroral Radar Experiment), developed by the Leicester University Ionospheric Physics group, is described. The first two chapters review previous studies of the atmosphere by radar techniques and includes a description of the SABRE radar. The basic radar equation and velocity relationships are derived and the various loss factors examined. From analysis of the echo signal data for the diffuse aurora, and examination of signal data from a radio star, the SABRE radar parameters are established. An investigation is then undertaken of the variation of the electrojet parameters, (derived from application of the radar equation to the SABRE data), with height, electric field strength and geomagnetic conditions. Evidence is found of backscattering from irregularities generated by both two-stream and gradient drift processes. An examination is also made of the echo signals detected at relatively short ranges, of below 370 km, and several causal mechanisms are investigated including scattering processes in the neutral atmosphere. It is evident that aircraft are predominantly the cause of these short-range echoes. This investigation also reveals a number of software and hardware faults in the initial radar configuration. This Thesis is concluded with suggestions for future development of the radar system, which include the implementation of a height-finding facility and improved spectral resolution.
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Soto, Gallupe Jhonny. "Proyecto inmobiliario edificio Parque Aurora." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2010. http://hdl.handle.net/10757/274026.

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El proyecto inmobiliario al que se refiere el presente documento, nace en un entorno bastante favorable, quedando supeditado sus resultados únicamente al desempeño de la organización que la llevará adelante, lo que en buena medida importa la optimización de las decisiones de los cuadros directivos e igualmente el cabal desempeño de los miembros de la organización a todos sus niveles Esto último en buena cuenta garantizará en gran medida el éxito del proyecto
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Books on the topic "La Aurora"

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Torosian, Michael. Aurora. [New York]: Marcuse Pfeifer Gallery, 1987.

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Lowe, Steve. Aurora. New York: Dodd, Mead, 1985.

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Colomé, Pura López. Aurora. México: Ediciones del Equilibrista, 1994.

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Aurora. Charleston, SC: Arcadia Pub., 2006.

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Thesen, Sharon. Aurora. Toronto, Ontario, Canada: Coach House Press, 1995.

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Aurora. London: Atlas Press, 1990.

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Aurora. London: Macmillan Children's, 2011.

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Minion, Robin. Aurora. Edmonton, Alta: Boreal Institute for Northern Studies, 1985.

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Barreto, Bertha Herrera. Aurora. Barranquilla, Colombia: Editorial Antillas, 1999.

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Thesen, Sharon. Aurora. Toronto: Coach House Press, 1995.

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Book chapters on the topic "La Aurora"

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Akasofu, Syun-Ichi. "Aurora." In From the Sun: Auroras, Magnetic Storms, Solar Flares, Cosmic Rays, 1–11. Washington, D. C.: American Geophysical Union, 1998. http://dx.doi.org/10.1029/sp050p0001.

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Burgess, Colin. "A replacement astronaut." In Aurora 7, 1–27. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_1.

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Burgess, Colin. "From Colorado to the Cape." In Aurora 7, 28–54. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_2.

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Burgess, Colin. "Mission planning for MA-7." In Aurora 7, 55–78. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_3.

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Burgess, Colin. "Aurora 7 in orbit." In Aurora 7, 79–106. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_4.

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Burgess, Colin. "A highly troubled mission." In Aurora 7, 107–24. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_5.

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Burgess, Colin. "Walter Cronkite: “We may have lost an astronaut”." In Aurora 7, 125–64. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_6.

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Burgess, Colin. "From astronaut to aquanaut." In Aurora 7, 165–94. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_7.

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Burgess, Colin. "Epilogue: The man and his spacecraft." In Aurora 7, 195–208. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20439-0_8.

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Biswas-Fiss, Esther E., Stephanie Affet, Malissa Ha, Takaya Satoh, Joe B. Blumer, Stephen M. Lanier, Ana Kasirer-Friede, et al. "Aurora Kinases." In Encyclopedia of Signaling Molecules, 177–83. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_81.

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Conference papers on the topic "La Aurora"

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Abadi, D., A. Rasin, A. Singer, M. Stonebraker, N. Tatbul, Y. Xing, R. Yan, et al. "Aurora." In the 2003 ACM SIGMOD international conference on. New York, New York, USA: ACM Press, 2003. http://dx.doi.org/10.1145/872757.872855.

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Huang, Anita W., and Neel Sundaresan. "Aurora." In Proceedings on the 2000 conference. New York, New York, USA: ACM Press, 2000. http://dx.doi.org/10.1145/355460.355546.

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Nguyen, Minh-Tien, Dung Tien Le, Le Thai Linh, Nguyen Hong Son, Do Hoang Thai Duong, Bui Cong Minh, Nguyen Hai Phong, and Nguyen Huu Hiep. "AURORA." In CIKM '20: The 29th ACM International Conference on Information and Knowledge Management. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3340531.3417434.

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Verbitski, Alexandre, Anurag Gupta, Debanjan Saha, James Corey, Kamal Gupta, Murali Brahmadesam, Raman Mittal, et al. "Amazon Aurora." In SIGMOD/PODS '18: International Conference on Management of Data. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3183713.3196937.

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Verbitski, Alexandre, Anurag Gupta, Debanjan Saha, Murali Brahmadesam, Kamal Gupta, Raman Mittal, Sailesh Krishnamurthy, Sandor Maurice, Tengiz Kharatishvili, and Xiaofeng Bao. "Amazon Aurora." In SIGMOD/PODS'17: International Conference on Management of Data. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3035918.3056101.

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Wang, Yuhang, Hui Zhao, Xian Zhang, and Jimin Liang. "A Big Aurora Data Management Framework Toward Aurora Classification." In 2017 IEEE 15th Intl Conf on Dependable, Autonomic and Secure Computing, 15th Intl Conf on Pervasive Intelligence and Computing, 3rd Intl Conf on Big Data Intelligence and Computing and Cyber Science and Technology Congress(DASC/PiCom/DataCom/CyberSciTech). IEEE, 2017. http://dx.doi.org/10.1109/dasc-picom-datacom-cyberscitec.2017.206.

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Lay, Sebastian, Jo Vermeulen, Charles Perin, Eric Donovan, Raimund Dachselt, and Sheelagh Carpendale. "Slicing the Aurora." In ISS '16: 2016 ACM International Conference on Interactive Surfaces and Spaces. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/3009939.3009954.

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Alex, Kurzhanskiy,. "Aurora Road Network Modeler." In Control in Transportation Systems, edited by Chassiakos, Anastasios, chair De Schutter, and Ioannou, Petros. Elsevier, 2009. http://dx.doi.org/10.3182/20090902-3-us-2007.00032.

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Ajay Chandna. "The Aurora RAM Compiler." In 32nd Design Automation Conference. ACM, 1995. http://dx.doi.org/10.1109/dac.1995.250101.

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Chandna, Ajay, C. David Kibler, Richard B. Brown, Mark Roberts, and Karem A. Sakallah. "The Aurora RAM compiler." In the 32nd ACM/IEEE conference. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/217474.217539.

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Reports on the topic "La Aurora"

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Cheng, Jin Q., and Santo V. Nicosia. Aurora-A Oncogene in Human Ovarian Cancer. Fort Belvoir, VA: Defense Technical Information Center, November 2005. http://dx.doi.org/10.21236/ada446899.

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Cheng, Jin Q. Aurora-A Oncogene in Human Ovarian Cancer. Fort Belvoir, VA: Defense Technical Information Center, November 2006. http://dx.doi.org/10.21236/ada462676.

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Buvelot, Stephanie, and Sue Biggins. Regulation and Functions of the Ipll/Aurora Kinase. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada416064.

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Kotwaliwale, Chitra, and Sue Biggins. Regulation and Function of the Ipl1/Aurora Kinase. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada432454.

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Nelson, Matthew, and Christine N. Jensen. "Aurora", Zero Pressure Balloon Project at Iowa State University. Ames (Iowa): Iowa State University. Library. Digital Press, January 2012. http://dx.doi.org/10.31274/ahac.8336.

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Schlyer, David, and Michael Furey. Development of PET Imaging Insert for Aurora Breast MRI System. Office of Scientific and Technical Information (OSTI), October 2013. http://dx.doi.org/10.2172/1095918.

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Bailey, V. L. Aurora Upgrade: Volume 3. Gradient B Drift Transport Risetime Sharpening. Fort Belvoir, VA: Defense Technical Information Center, April 1988. http://dx.doi.org/10.21236/ada213029.

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PARSONS ENGINEERING SCIENCE INC DENVER CO. Environmental Baseline Survey, Fitzsimmons Army Medical Center, Aurora, Colorado. Volume I. Fort Belvoir, VA: Defense Technical Information Center, May 1996. http://dx.doi.org/10.21236/ada323540.

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Miller, Naomi J. GATEWAY Demonstrations: OLED Lighting in the Offices of Aurora Lighting Design, Inc. Office of Scientific and Technical Information (OSTI), March 2016. http://dx.doi.org/10.2172/1377011.

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Jay R. Johnson and Hideo Okuda. Cross-Field Current Instabilities in Thin Ionization Layers and the Enhanced Aurora. Office of Scientific and Technical Information (OSTI), May 2008. http://dx.doi.org/10.2172/959386.

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