Relevant bibliographies by topics / Laboratory animals

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Laboratory animals'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Laboratory animals"

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Cox, F. E. G. "Parasites of laboratory animals: Laboratory animal handbooks no. 12." Parasitology Today 8, no. 12 (December 1992): 429–30. http://dx.doi.org/10.1016/0169-4758(92)90199-c.

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Clarke, Maxine. "Animal welfare: Protesters as laboratory animals." Nature 313, no. 6005 (February 1985): 725. http://dx.doi.org/10.1038/313725b0.

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VISVANATHAN, K. V. "Laboratory animals." Nature 313, no. 5999 (January 1985): 176. http://dx.doi.org/10.1038/313176a0.

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Van den Bogaard, A. E. J. M. "Laboratory animals." Veterinary Microbiology 17, no. 1 (May 1988): 95–96. http://dx.doi.org/10.1016/0378-1135(88)90086-7.

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Agrup, G., L. Belin, L. Sjostedt, and S. Skerfving. "Allergy to laboratory animals in laboratory technicians and animal keepers." Occupational and Environmental Medicine 43, no. 3 (March 1, 1986): 192–98. http://dx.doi.org/10.1136/oem.43.3.192.

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KOSTOMITSOPOULOS (Ν. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ), N. "Ethics and laboratory animals." Journal of the Hellenic Veterinary Medical Society 60, no. 1 (November 17, 2017): 75. http://dx.doi.org/10.12681/jhvms.14916.

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Despite all the benefits, the use of animals in biomedical research was, and still is, a subject of debate with respect to its true usefulness. The sensitivity of the community and the interest of scientists working in the field of laboratory animal science and welfare have clearly demonstrated that the use of animals in biomedical research must be conducted under specific scientific, legal and ethical rules. The ethical justification of a research project starts from the initial designing phase of the project until the completion of the study and the review of the obtained results. Main considerations of an ethical documentation are: the precise definition of the goals of the project and the existing probabilities for its success, the selection of the appropriate animal model, the implementation of the 3Rs' concept for replacement, reduction and refinement, a cost/benefit analysis on the expected benefits for science and society with direct consideration to the harm created to animals, a pilot study and a systematic review of previously published animal research on the topic, the availability of the appropriate facilities, equipment and expertise to guarantee high standards of animal accommodation, husbandry, care and use. The ethical documentation of a project by scientists themselvesinvolves team work and a sustainable rather than a one-off procedure. The ethical justification of the laboratory animal research protocols reflects the interest and the responsibility of scientists for reduction and refinement of animal experimentation. Thisprocess built a trust relationship between scientists and the society.
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Bryant, David H., Lynette M. Boscato, Paul N. Mboloi, and Margaret C. Stuart. "Allergy to laboratory animals among animal handlers." Medical Journal of Australia 163, no. 8 (October 1995): 415–18. http://dx.doi.org/10.5694/j.1326-5377.1995.tb124657.x.

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Shyan-Norwalt, Melissa R. "The human–animal bond with laboratory animals." Lab Animal 38, no. 4 (April 2009): 132–36. http://dx.doi.org/10.1038/laban0409-132.

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Swinbanks, David. "Laboratory animals unprotected." Nature 322, no. 6075 (July 1986): 103. http://dx.doi.org/10.1038/322103a0.

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McAllister Groves, Julian. "Are Smelly Animals Happy Animals? Competing Definitions of Laboratory Animal Cruelty and Public Policy." Society & Animals 2, no. 2 (1994): 125–44. http://dx.doi.org/10.1163/156853094x00144.

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AbstractRegulations surrounding laboratory animal care have tried to address aspects of an image of laboratory animal cruelty publicized by animal rights activists. This image of cruelty, however, is not consistent with the experiences of those charged with the day-to-day care of laboratory animals. This article examines the incongruities between the public image of cruelty to animals in laboratories as promoted by animal rights activists, and the experiences of laboratory animal care staff who apply and enforce laboratory animal care regulations. In doing so, the article illuminates why regulations surrounding laboratory animal care are difficult to comply with on the part of the policy enforcers, and are continuously contested by both animal rights activists and animal research personnel.
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Dissertations / Theses on the topic "Laboratory animals"

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Kirk, Robert George William. "Reliable animals, responsible scientists : constructing standard laboratory animals in Britain c.1919-1976." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445731/.

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This thesis explores the attempt to construct a national supply of standard laboratory- animals in Britain between 1919 and 1976. The demand for a national supply of standard laboratory-animals is located in the formation during the interwar period of the discipline of biological standardization. In contrast to other disciplines within the sciences biological standardization placed great emphasis upon the routine replication of experimental results. In consequence the field of biological standardization problematized the laboratory-animal and sought its standardization in order to construct it as a reliable diagnostic tool. In 1947 the Medical Research Council responded to pressure from an unprecedented coalition of scientific societies and established the Laboratory Animals Bureau tasked with regulating the British laboratory-animal production toward producing standard laboratory-animals. The work of the Laboratory Animal Bureau is analysed but the main focus of the thesis is upon the relationship between the practices of standardization and the promotion of the welfare of laboratory-animals. Particularly after the close of the Second World War the project to standardize laboratory-animals became increasingly associated with the promotion of their welfare. The relationship between the two was made explicit through the work of the Universities Federation for Animal Welfare in collaboration with the Laboratory Animals Bureau. In order to understand the relationship between standardization and welfare Michel Foucault's concept of biopower is employed. It is subsequently argued that the analytics of biopower need not be restricted to human life but equally encompasses non-human life. Through the Foucaultian perspective of biopower it is argued that standardization and welfare are two poles of the same biopolitical process.
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Lainetti, Elizabeth Brigagão de Faria. "Proposta conceitual de uma instalação para manuseio de mini porcos (minipigs) utilizados em pesquisas científicas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-22022019-143417/.

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Para a realização de pesquisas científicas biológicas universais e reprodutivas, é fundamental a produção e o fornecimento de animais de laboratório de alta qualidade. Contudo, a qualidade e a saúde desses animais dependem, em grande parte, das instalações disponíveis para a sua produção e alojamento, de forma a garantir a qualidade sanitária e o seu bem-estar, respeitando os princípios éticos que regem a atividade. Nas instalações destinadas a criação, manutenção e experimentação com animais de laboratório são adotadas diretrizes, tanto nacionais como internacionais, para garantir a biossegurança e o bem-estar animal. Além disso, as instalações devem preencher outros requisitos, tais como: a funcionalidade dos ambientes, que devem possibilitar o manejo adequado e eficiente dos animais, facilitando a execução das atividades rotineiras; a climatização ambiental; a instalação de barreiras sanitárias para limitar e impedir o acesso de agentes indesejáveis; o respeito a princípios ergonômicos, para proporcionar um ambiente seguro e o bem-estar dos operadores; a biossegurança, para prevenir, minimizar ou eliminar riscos à saúde do homem e dos animais, a preservação do meio ambiente e a qualidade dos resultados. Dessa forma, o projeto das instalações é de importância vital para que os requisitos mencionados sejam atingidos, com a obtenção de animais sadios, com o mínimo de estresse, proporcionando o bem-estar e reduzindo variações que podem afetar os resultados de pesquisa. Neste documento, é apresentada uma introdução com a importância do suíno na medicina e na experimentação animal, além de alguns parâmetros importantes adotados na construção de instalações destinadas à criação e alojamento desta espécie. Finalmente, é apresentado um projeto conceitual de uma instalação, que reunirá características que representem o estado-da-arte sobre o assunto, para que o espaço destinado ao alojamento dos animais atenda, da melhor maneira, as recomendações sobre aspectos inerentes dos animais de laboratório, com relação à saúde, à alimentação, controle da transmissão de doenças, á adequação das instalações às exigências e às normas internacionais que visam o bem-estar animal. O projeto da instalação reunirá características únicas e inéditas, para que seja possível realizar pesquisas científicas avançadas, contribuindo para o crescimento da ciência nacional, bem como para o desenvolvimento inovador no âmbito da CNEN.
In order to carry out outstanding universal and reproductive biological scientific research, the production and supply of high quality laboratory animals are of fundamental importance. However, the quality and health of these animals depends on a large extent on the facilities available for their production and housing in order to ensure the sanitary quality and their well-being, respecting the ethical principles governing the activity. National and international guidelines for facilities for breeding, maintenance and testing of laboratory animals are aimed, among other things, biosafety and animal welfare. In addition, facilities must meet other requirements, such as: the functionality of the environments, which should allow the proper and efficient management of the animals, facilitating the execution of routine activities; environmental air conditioning; the installation of sanitary barriers to limit and prevent access of undesirable agents; respect for ergonomic principles, to provide a safe environment and the well-being of operators; biosafety, to prevent, minimize or eliminate risks to the health of man and animals, the preservation of the environment and the quality of results. In this way, the design of the facilities is of vital importance in order to achieve the mentioned requirements, obtaining healthy animals with minimum stress, providing well-being and reducing variations that can affect the results of research. This paper presents an introduction to the importance of pig in medicine and animal experimentation, as well as some important parameters adopted in the construction of facilities for breeding and housing of this specie. Finally, a conceptual design of an installation is presented, which will bring up characteristics that represent the state of the art on the subject, so that the space destined to the housing of the animals meets, in the best way, the recommendations on inherent aspects of laboratory animals, with regard to health, food, control transmission of diseases, adaptation of facilities to international requirements and standards for animal welfare. The facilities project will bring also unique and unprecedented features, so that it is possible to carry out scientific cutting-edge research, contributing to the further development of national science, as well as innovative research within CNEN.
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Moreira, Virgínia Barreto [UNESP]. "Eficiência reprodutiva e comportamento parental de camundongos isogênicos e heterogênicos produzidos em ambiente modificado." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/126631.

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O objetivo deste estudo foi avaliar a preferência e efeito do fornecimento de materiais de nidificação sobre o desempenho reprodutivo de camundongos isogênicos da linhagem BALB/c e da linhagem heterogênica Swiss em sistema de acasalamento intensivo monogâmico. Primeiro foi realizado um estudo para avaliar a preferência dos camundongos pelo material oferecido para nidificação. Utilizou-se um sistema composto de quatro gaiolas, com livre acesso a água e ração, interligados por tubos de PVC que permitiam que os animais se locomovessem entre todas as gaiolas. Quatro tipos de materiais foram oferecidos para a construção do ninho: algodão, gaze, rolinho de papelão, e touca de polipropileno descartável. Cada um dos quatro materiais foi oferecido simultaneamente em uma das quatro gaiolas que compunham o sistema. Foram usados 10 sistemas iguais e cada um abrigou um casal da linhagem BALB/c, desde os 28 dias de idade até o terceiro ciclo reprodutivo. Os mais encontrados na confecção do ninho, em ordem decrescente, foram a touca, rolinho, algodão e gaze (P< 0,0083). Com base nestes resultados foram selecionados dois tipos de materiais para fornecimento aos animais no experimento 2. Embora o rolinho tenha sido o segundo material mais utilizado optou-se pelo algodão devido a inviabilidade de fornecimento do item durante todo o período de duração do experimento 2. O segundo experimento avaliou a eficiência reprodutiva em cinco ciclos reprodutivos do nascimento até o desmame. Usou-se 60 casais de irmãos completos da linhagem BALB/c (isogênica) e 60 casais formados por acasalamentos aleatórios da linhagem Swiss (heterogênica) de padrão sanitário controlado, criados e mantidos em ambiente padronizado. Eles foram distribuídos, num delineamento inteiramente casualizado, em arranjo fatorial 2x2 (duas linhagens em alojamento com ou sem material para nidificação). Como forma de ...
The objective of this study was to evaluate the preference and effect of nesting materials provision on performance of inbred mice of the BALB/c strain and of heterogenic Swiss in intensive monogamous mating system. Firstly, a study was conducted to evaluate the preference of mice for the material offered for nesting. A system composed of four cages was used, with free access to water and food, connected by PVC tubing, which allowed animal displacement among all cages. Four types of materials were available for construction of the nest: cotton, gauze, cardboard rolls, and disposable polypropylene cap. Each of the four materials was offered simultaneously in one of four cages that formed the system. Ten identical system were used and each one housed a BALB/c couple, from 28 days of age up to the third reproductive cycle. The most commonly found materials in nest making were cap, roll, cotton and gauze (P <0.0083). Based on these results, two types of materials were selected to be offered to the animals in experiment 2. Although the roll was the second most used material, we chose cotton due to unfeasibility supplying of the item throughout the duration of the second experiment. The second experiment evaluated the reproductive efficiency in five reproductive cycles from birth to weaning. Sixty BALB / c full siblings pairs (inbred) and 60 pairs formed by random mating of Swiss strain (outbred), bred and maintained in a standardized environment were used. They were distributed in a completely randomized design in a 2x2 factorial arrangement (two strains in housing with or without nesting material). As a way of cage enrichment, polypropylene disposable cap cut into 8 pieces of approximately 1 cm each and one piece of cotton about 3 g were used after being previously packaged and autoclaved . The following characteristics were evaluated: age at first parturition, litter intervals, pre-weaning mortality and ...
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Draper, Adrian. "Gene & environmental interactions in sensitization to laboratory animals and other epidemiological aspects of laboratory animal allergy in the United Kingdom." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519616.

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Moreira, Virgínia Barreto 1974. "Eficiência reprodutiva e comportamento parental de camundongos isogênicos e heterogênicos produzidos em ambiente modificado /." Botucatu, 2015. http://hdl.handle.net/11449/126631.

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Orientador: Ana Silvia Alves Meira Tavares Moura
Banca: Simone Fernandes
Banca: Valderez Bastos Valero-Lapckick
Banca: Denose Rangel da Silva Sartori
Banca: Luiz Edivaldo Pezzato
Resumo: O objetivo deste estudo foi avaliar a preferência e efeito do fornecimento de materiais de nidificação sobre o desempenho reprodutivo de camundongos isogênicos da linhagem BALB/c e da linhagem heterogênica Swiss em sistema de acasalamento intensivo monogâmico. Primeiro foi realizado um estudo para avaliar a preferência dos camundongos pelo material oferecido para nidificação. Utilizou-se um sistema composto de quatro gaiolas, com livre acesso a água e ração, interligados por tubos de PVC que permitiam que os animais se locomovessem entre todas as gaiolas. Quatro tipos de materiais foram oferecidos para a construção do ninho: algodão, gaze, rolinho de papelão, e touca de polipropileno descartável. Cada um dos quatro materiais foi oferecido simultaneamente em uma das quatro gaiolas que compunham o sistema. Foram usados 10 sistemas iguais e cada um abrigou um casal da linhagem BALB/c, desde os 28 dias de idade até o terceiro ciclo reprodutivo. Os mais encontrados na confecção do ninho, em ordem decrescente, foram a touca, rolinho, algodão e gaze (P< 0,0083). Com base nestes resultados foram selecionados dois tipos de materiais para fornecimento aos animais no experimento 2. Embora o rolinho tenha sido o segundo material mais utilizado optou-se pelo algodão devido a inviabilidade de fornecimento do item durante todo o período de duração do experimento 2. O segundo experimento avaliou a eficiência reprodutiva em cinco ciclos reprodutivos do nascimento até o desmame. Usou-se 60 casais de irmãos completos da linhagem BALB/c (isogênica) e 60 casais formados por acasalamentos aleatórios da linhagem Swiss (heterogênica) de padrão sanitário controlado, criados e mantidos em ambiente padronizado. Eles foram distribuídos, num delineamento inteiramente casualizado, em arranjo fatorial 2x2 (duas linhagens em alojamento com ou sem material para nidificação). Como forma de ...
Abstract: The objective of this study was to evaluate the preference and effect of nesting materials provision on performance of inbred mice of the BALB/c strain and of heterogenic Swiss in intensive monogamous mating system. Firstly, a study was conducted to evaluate the preference of mice for the material offered for nesting. A system composed of four cages was used, with free access to water and food, connected by PVC tubing, which allowed animal displacement among all cages. Four types of materials were available for construction of the nest: cotton, gauze, cardboard rolls, and disposable polypropylene cap. Each of the four materials was offered simultaneously in one of four cages that formed the system. Ten identical system were used and each one housed a BALB/c couple, from 28 days of age up to the third reproductive cycle. The most commonly found materials in nest making were cap, roll, cotton and gauze (P <0.0083). Based on these results, two types of materials were selected to be offered to the animals in experiment 2. Although the roll was the second most used material, we chose cotton due to unfeasibility supplying of the item throughout the duration of the second experiment. The second experiment evaluated the reproductive efficiency in five reproductive cycles from birth to weaning. Sixty BALB / c full siblings pairs (inbred) and 60 pairs formed by random mating of Swiss strain (outbred), bred and maintained in a standardized environment were used. They were distributed in a completely randomized design in a 2x2 factorial arrangement (two strains in housing with or without nesting material). As a way of cage enrichment, polypropylene disposable cap cut into 8 pieces of approximately 1 cm each and one piece of cotton about 3 g were used after being previously packaged and autoclaved . The following characteristics were evaluated: age at first parturition, litter intervals, pre-weaning mortality and ...
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Delpire, Veronique Charline. "Ethical schemes for the use of transgenic laboratory animals." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324118.

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Burt, John Michael. "Birdsong communication and perception : field and laboratory studies /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9129.

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Agarwal, Rajat. "A model for minimizing cost for housing laboratory mice." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001241.

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Carrillo, Martha. "Studies on protective immunity to toxocara canis in laboratory animals /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487671108307319.

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Ali, Cairo F. "Animal rights and animal research." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1371556393.

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Books on the topic "Laboratory animals"

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Joost, Ruitenberg E., and Peters P. W. J, eds. Laboratory animals: Laboratory animal models for domestic animal production. Amsterdam: Elsevier Science Publishers, 1986.

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A, Suckow Mark, Weisbroth Steven H, and Franklin Craig L, eds. The laboratory rat. Amsterdam: Elsevier Academic Press, 2005.

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Gluckstein, Fritz P. Laboratory animal welfare. Bethesda, Md: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Public Service Division, 1988.

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Gluckstein, Fritz P. Laboratory animal welfare. Bethesda, Md: Reference Services Division, National Library of Medicine, U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1985.

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Gluckstein, Fritz P. Laboratory animal welfare. Bethesda, Md: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Public Service Division, 1988.

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Sonia, Wolfe-Coote, ed. The laboratory primate. Amsterdam: Elsevier Academic Press, 2005.

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Gluckstein, Fritz P. Laboratory animal welfare. Bethesda, Md: Reference Services Division, National Library of Medicine, U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1985.

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J, Hedrich Hans, and Bullock Gillian R, eds. The laboratory mouse. Amsterdam: Elsevier Academic Press, 2004.

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1923-, Flynn Robert J., Baker David G. 1956-, Flynn Robert J. 1923-, and American College of Laboratory Animal Medicine., eds. Flynn's parasites of laboratory animals. 2nd ed. Ames, Iowa: Blackwell Pub., 2007.

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Hitzelberg, R. Laboratory manual for basic biomethodology of laboratory animals. Silver Spring, Md: MTM Associates, 1985.

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Book chapters on the topic "Laboratory animals"

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Lakshmanan, Mageshwaran. "Laboratory Animals." In Introduction to Basics of Pharmacology and Toxicology, 13–36. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5343-9_2.

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Hendriksen, Coenraad F. M. "Experimental Animals and Animal Experiments." In Laboratory Animals in Vaccine Production and Control, 37–49. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-1321-9_5.

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Remie, René. "Anaesthesia in Laboratory Animals." In Rodent Model as Tools in Ethical Biomedical Research, 113–27. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-11578-8_9.

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Knight, Andrew. "Impacts on Laboratory Animals." In The Costs and Benefits of Animal Experiments, 29–36. London: Palgrave Macmillan UK, 2011. http://dx.doi.org/10.1057/9780230306417_4.

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Liu, Enqi, and Jianglin Fan. "Welfare of Laboratory Animals." In Fundamentals of Laboratory Animal Science, 25–62. Boca Raton : CRC Press, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315368993-2.

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Utne-Palm, Anne Christine, and Adrian Smith. "Fish as Laboratory Animals." In Animal Welfare, 375–400. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41675-1_16.

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Ware, Wendy A., John D. Bonagura, and Brian A. Scansen. "Clinical Laboratory Abnormalities." In Cardiovascular Disease in Companion Animals, 287–96. 2nd ed. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780429186639-21.

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Wordsworth, Anne M. "The Laboratory Mouse." In Law, Animals and Toxicity Testing, 53–66. London: Routledge, 2024. http://dx.doi.org/10.4324/9781032646350-4.

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Ebert, Karl M. "Prospective Developments in Laboratory Animals." In Animal Patents, 61–69. London: Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10769-8_8.

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Andersen, Monica Levy, Vânia D’Almeida, Gui Mi Ko, Paulo José Forcina Martins, and Sergio Tufik. "The Health of Laboratory Animals." In Rodent Model as Tools in Ethical Biomedical Research, 53–60. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-11578-8_6.

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Conference papers on the topic "Laboratory animals"

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Koniar, Dusan, Libor Hargas, Zuzana Loncova, Frantisek Duchon, and Peter Beno. "Laboratory animals tracking in videosequences." In 2016 ELEKTRO. IEEE, 2016. http://dx.doi.org/10.1109/elektro.2016.7512134.

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Naida, Christopher G. "Construction Vibration Mitigation for Laboratory Animals." In Geotechnical Earthquake Engineering and Soil Dynamics V. Reston, VA: American Society of Civil Engineers, 2018. http://dx.doi.org/10.1061/9780784481462.030.

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Stadnik, A., O. Streltsova, D. Podgayny, Yu Butenko, K. Golikova, Yu Severiukhin, D. Utina, and A. Nartikov. "ALGORITHMS FOR BEHAVIORAL ANALYSIS OF LABORATORY ANIMALS IN RADIOBIOLOGICAL RESEARCH." In 9th International Conference "Distributed Computing and Grid Technologies in Science and Education". Crossref, 2021. http://dx.doi.org/10.54546/mlit.2021.65.91.001.

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As part of the development of an information system for radiobiological research, an algorithmic unitfor analyzing video recordings of the behavior of laboratory animals to study the dependence onpathomorphological changes in the central nervous system after exposure to ionizing radiation andother factors. The analysis of data characterizing the behavioral responses of a laboratory animal basedon machine and deep learning algorithms and computer vision methods. To achieve the goal of fullyautomating the processing of data from behavioral experiments, it is necessary to develop severalgroups of algorithms: algorithms for automated marking of the field of an experimental setup,algorithms for tracking the position of a mouse in an experimental setup of various types, andalgorithms for assessing the characteristic behavioral patterns of an animal characterizing its emotionalstate. The paper proposes approaches and specific algorithms developed for use within the informationsystem for processing data from radiobiological research.
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Mikheeva, N. A., E. P. Drozhdina, and N. A. Kurnosova. "Morphofunctional features of proliferating cells exposed to PSMA peptide." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-142-144.

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The effect of the synthetic PSMA peptide on dividing cells of laboratory animals was studied. The experiment was carried out on male white laboratory mice of the BALB/c-line. The toxic effect of PSMA peptidi was evaluated at therapeutic (1.4 μg / kg of animal weight or 0.04 μg / animal) and subtoxic (140 μg / kg of animal weight or 4.0 μg / animal) doses. The cytotoxic effect of PSMA peptide on red bone marrow cells and cambial intestinal cells of the of laboratory mice was determined. A decrease in the proliferative activity of the colon crypt cells was revealed upon administration of a subtoxic dose of the PSMA peptide and there were no signs of toxic damage to the red bone marrow cells of animals. Key words: toxicity, proliferation, synthetic peptides, mitotic index, micronucleus test.
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Caraba, Marioara Nicoleta, Ion Valeriu Caraba, Adrian Sinitean, Gabi Dumitrescu, and Roxana Popescu. "ADMINISTRATION OF OCHRATOXIN A TO LABORATORY ANIMALS AND ITS EFFECTS ON BLOOD PARAMETERS." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023/6.1/s25.12.

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Mycotoxins are agents with different and complex chemical structures, with toxic effects for humans and animals. They can be present in feed and food, although in very small quantities, mycotoxins have a negative effect on the health of animals and people. Ochratoxins are mycotoxins intensively studied in recent years due to their toxicity on the animal and human body; these toxins show nephrotoxic, immunotoxic and myelotoxic, neurotoxic and carcinogenic effects. Thirty male rats of the Sprague- Dawley breed were divided into 3 groups who received through feed doses of of ochratoxin A (OTA): 0.5 mg OTA/kg BW, 1 mg OTA/kg BW and non OTA (control group). The blood samples collected on the anticoagulant were subjected to the analysis of the main components: hemoleucogram and biochemical parameters. The variations of the determined biochemical parameters (alanine aminotransferase, aspartat aminotransferase, serum creatinin, serum urea and blood urea nitrogen) indicate changes in the kidney and liver function in the animals from the experimental groups compared to the control group. The parameters of the hemoleucogram count also register variations depending on the administered dose of OTA.
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Polukhina, D. N., O. A. Panova, and O. P. Kurnosova. "PARASITE FAUNA OF LABORATORY MICE." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.376-380.

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Mice are widely used as laboratory animals. Diagnosis of endoparasites is a necessary condition: this is a culling indicator of animals for SPF (specific pathogen free) vivariums, and for conventional vivariums, it is the necessary information for planning and the possibility of using these animals in various tests. This article describes live-time diagnostics of endoparasites in laboratory mice in SPF vivariums and in open-type vivariums. For the study, individual samples of faeces and bedding were taken from laboratory mice. Direct fecal smears were examined and the flotation method was used. The work was carried out in 2021–2022 in the Laboratory of Biology and Biological Basis of Preventive Measures of the VNIIP – FSC VIEV. During this study, the following 180 samples were taken: 138 individual faecal samples, 34 samples combined with the bedding, and 18 bedding samples. The studied samples were found to contain Giardia muris and Tritrichomonas sp., nematodes Aspiculuris tetraptera and Syphacia obvelata, and cestode Rodentolepis nana. Mixed invasions were also recorded. The results showed the need for planning work with laboratory mice in vivariums.
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Maxwell, Paul, Howard Jay Siegel, and Jerry Potter. "The ISTeC People-Animals-Robots laboratory: Robust resource allocation." In Rescue Robotics (SSRR). IEEE, 2009. http://dx.doi.org/10.1109/ssrr.2009.5424142.

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Conrad, David, John Emond, and Louis Stodieck. "Automation for improved physiological research in microgravity using laboratory animals." In Space Programs and Technologies Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1996. http://dx.doi.org/10.2514/6.1996-4326.

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Krotova, Maria G. "Evaluation of the quality of antler hydrolysate on laboratory animals." In Агропромышленный комплекс: проблемы и перспективы развития. Благовещенск: Дальневосточный государственный аграрный университет, 2022. http://dx.doi.org/10.22450/9785964205517_4_18.

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Jasim, Fatimah, and Fatima Abass. "Bienertia Sinuspersici Leaves Extracts Accelerated Wound Healing in laboratory animals." In Proceedings of the 1st International Multi-Disciplinary Conference Theme: Sustainable Development and Smart Planning, IMDC-SDSP 2020, Cyperspace, 28-30 June 2020. EAI, 2020. http://dx.doi.org/10.4108/eai.28-6-2020.2297924.

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Reports on the topic "Laboratory animals"

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Zurlo, Joanne. Institute of Laboratory Animals Research (ILAR). Fort Belvoir, VA: Defense Technical Information Center, March 2003. http://dx.doi.org/10.21236/ada416653.

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Corscadden, Louise, and Arpaporn Sutipatanasomboon. Rodent Tagging And Identification. ConductScience, January 2023. http://dx.doi.org/10.55157/cs20230109.

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Animal tagging is a means to identify and distinguish all the individual animals of interest, which applies to wildlife, farm, or laboratory animals. It involves attaching a tag to a specific animal part that contains a unique identifier for each animal. The identifier can be numbers, alphabets, or a combination of both that distinguish and track the animals throughout their lifespans. In rodents, tagging is the most popular identification approach. Typically, tags are made from metals and attached to the outer part of rodent ears, or the ear pinna. In rare circumstances, metal tags can also be attached to the rodent’s leg or tail.
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Shantyz, A. K., P. V. Miroshnichenko, E. S. Sadikova, and V. V. Menshenin. Changes in hematological and biochemical blood parameters in laboratory animals with experimental escherichiosis. Краснодарский научный центр по зоотехнии и ветеринарии, 2018. http://dx.doi.org/10.18411/88sh-e5337.

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Corscadden, Louise, and Arpaporn Sutipatanasomboon. What Is Operant Behavior And How To Study It. Maze Engineers, December 2022. http://dx.doi.org/10.55157/me2022127.

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Operant behavior describes a type of voluntary goal-directed actions in animals based on the repercussions of previous occurrences. It develops when animals learn to specifically respond to recurring situations based on the outcome of their past experience. American psychologist B.F. Skinner was the first to use operant to describe the behaviors he observed in his landmark experiments in laboratory animals. Operant behavior and conditioning refine the nuance between conscious and unconscious behavioral responses, which influence psychology, and applied behavior analysis, and improve our understanding of addiction, substance dependence, child development, and decision-making.
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Jung, Carina, Matthew Carr, Denise Lindsay, Eric Fleischman, and Chandler Roesch. Microbiome perturbations during domestication of the green June beetle (Cotinis nitida). Engineer Research and Development Center (U.S.), February 2022. http://dx.doi.org/10.21079/11681/43342.

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Animal-associated microbiomes are critical to the well-being and proper functioning of the animal host, but only limited studies have examined in-sect microbiomes across different developmental stages. These studies revealed large shifts in microbiome communities, often because of significant shifts in diet during insects’ life cycle. Establishing insect colonies as model laboratory organisms and understanding how to properly feed and care for animals with complex and dynamic life cycles requires improved data. This study examined laboratory raised green June beetles (Cotinis nitida) captured from the field upon emergence from pupae. Starting with wild-caught adults, two generations of beetles were reared in the laboratory, ending with an entirely laboratory raised generation of larvae. The study compared the microbiomes of each generation and the microbiomes of larvae to adults. This study suggests that a diet of commercial, washed fruit for adults and commercial, packaged, organic alfalfa meal for larvae resulted in depauperate gut microbiome communities. Fermentative yeasts were completely absent in the laboratory-raised adults, and major bacterial population shifts occurred from one generation to the next, coupled with high morbidity and mortality in the laboratory-raised generation. Providing laboratory-raised beetles fresh-collected fruit and the larvae field-harvested detritus may therefore vastly improve their health and survival.
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Matthew, Gray. Data from "Winter is Coming – Temperature Affects Immune Defenses and Susceptibility to Batrachochytrium salamandrivorans". University of Tennessee, Knoxville Libraries, January 2021. http://dx.doi.org/10.7290/t7sallfxxe.

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Environmental temperature is a key factor driving various biological processes, including immune defenses and host-pathogen interactions. Here, we evaluated the effects of environmental temperature on the pathogenicity of the emerging fungus, Batrachochytrium salamandrivorans (Bsal), using controlled laboratory experiments, and measured components of host immune defense to identify regulating mechanisms. We found that adult and juvenile Notophthalmus viridescens died faster due to Bsal chytridiomycosis at 14 ºC than at 6 and 22 ºC. Pathogen replication rates, total available proteins on the skin, and microbiome composition likely drove these relationships. Temperature-dependent skin microbiome composition in our laboratory experiments matched seasonal trends in wild N. viridescens, adding validity to these results. We also found that hydrophobic peptide production after two months post-exposure to Bsal was reduced in infected animals compared to controls, perhaps due to peptide release earlier in infection or impaired granular gland function in diseased animals. Using our temperature-dependent infection results, we performed a geographic analysis that suggested that N. viridescens populations in the northeastern United States and southeastern Canada are at greatest risk for Bsal invasion. Our results indicate that environmental temperature will play a key role in the epidemiology of Bsal and provide evidence that temperature manipulations may be a viable Bsal management strategy.
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Dechow, Chad Daniel, M. Cohen-Zinder, Morris Soller, Y. Tzfati, A. Shabtay, E. Lipkin, T. Ott, and W. Liu. Genotypes and phenotypes of telomere length in Holstein cattle, actors or reporters. Israel: United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134156.bard.

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Selection programs aiming at improving health and survival in cattle are complicated by low heritability estimates, the fact that true herd life and carcass quality is not known until the end of an animal's life, and that many health conditions manifest late in life. Young animals are now heavily favored in breeding programs because low generation intervals accelerate the rate of genetic progress, which means selection decisions must be made before phenotypic observation of health and survival is feasible. Moreover, profitability is compromised when livestock producers raise animals that fail to produce due to health failure or that do not meet quality standards. Telomere length (TL) was hypothesized as a biomarker that could be recorded early in life, be associated with health and survival, and have higher heritability than other measures of health. Thus, our research aims were to: 1, determine associations of TL with health, wellbeing and production in Holsteins raised for dairy or beef purposes; 2, determine TL heritability, genetic variance, and genetic correlations with cow health and performance; and 3, map quantitative trait loci affecting TL and provide TL genomic predictions to industry partners and breeders. There were not significant changes made to the research plan during the project, but the timeline of the project was not met. Laboratory processing of samples was significantly delayed due to Covid along with some sample collection. TL measurements from >1100 animals across the US and Israel are available to date. TL declines modestly with age, in agreement with observations from other species. A genomic analysis was conducted using a single-step approach and TL had a moderate heritability estimate of 20% across age groups. The initial genome-wide association-analysis indicated that TL is a quantitative trait whose expression is influenced by effects across the genome. Moreover, there is a strong association of calf and dam TL at birth. Genetic relationships with health and survival were ascertained through correlations of genomic estimated breeding values (gEBV) for TL with gEBV for other traits routinely recording in national genetic evaluations. Higher TL is genetically associated with longer herd-life, a greater likelihood that cows will avoid premature on-farm death, and reduced disease incidence. The relationship appeared to be strongest when TL was measured during the first two years of life. Based on genotyping different cell types, there was evidence that maternal and colostral derived cells are present in newborns, which could bias TL measurements during the first weeks of life to a small degree. The implications of this research are that TL is a promising trait to include in multiple trait selection programs because it is heritable, available early in life, and correlated with longevity and health. Our TL reference population is currently being expanded, and genomic estimated breeding values will be disseminated to industry partners upon completion of the reference population so that they can evaluate the utility of incorporating TL into their breeding programs.
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Zurlo, Joanne. Institute for Laboratory Animal Research. Fort Belvoir, VA: Defense Technical Information Center, April 2002. http://dx.doi.org/10.21236/ada400956.

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Greenhouse, Dorothy D. Institute of Laboratory Animal Resources. Fort Belvoir, VA: Defense Technical Information Center, June 1992. http://dx.doi.org/10.21236/ada261922.

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Dell, Ralph. Institute of Laboratory Animal Research. Fort Belvoir, VA: Defense Technical Information Center, April 2000. http://dx.doi.org/10.21236/ada377379.

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