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Journal articles on the topic 'Laboratory animals'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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1

Cox, F. E. G. "Parasites of laboratory animals: Laboratory animal handbooks no. 12." Parasitology Today 8, no. 12 (December 1992): 429–30. http://dx.doi.org/10.1016/0169-4758(92)90199-c.

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2

Clarke, Maxine. "Animal welfare: Protesters as laboratory animals." Nature 313, no. 6005 (February 1985): 725. http://dx.doi.org/10.1038/313725b0.

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3

VISVANATHAN, K. V. "Laboratory animals." Nature 313, no. 5999 (January 1985): 176. http://dx.doi.org/10.1038/313176a0.

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4

Van den Bogaard, A. E. J. M. "Laboratory animals." Veterinary Microbiology 17, no. 1 (May 1988): 95–96. http://dx.doi.org/10.1016/0378-1135(88)90086-7.

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5

Agrup, G., L. Belin, L. Sjostedt, and S. Skerfving. "Allergy to laboratory animals in laboratory technicians and animal keepers." Occupational and Environmental Medicine 43, no. 3 (March 1, 1986): 192–98. http://dx.doi.org/10.1136/oem.43.3.192.

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6

KOSTOMITSOPOULOS (Ν. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ), N. "Ethics and laboratory animals." Journal of the Hellenic Veterinary Medical Society 60, no. 1 (November 17, 2017): 75. http://dx.doi.org/10.12681/jhvms.14916.

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Despite all the benefits, the use of animals in biomedical research was, and still is, a subject of debate with respect to its true usefulness. The sensitivity of the community and the interest of scientists working in the field of laboratory animal science and welfare have clearly demonstrated that the use of animals in biomedical research must be conducted under specific scientific, legal and ethical rules. The ethical justification of a research project starts from the initial designing phase of the project until the completion of the study and the review of the obtained results. Main considerations of an ethical documentation are: the precise definition of the goals of the project and the existing probabilities for its success, the selection of the appropriate animal model, the implementation of the 3Rs' concept for replacement, reduction and refinement, a cost/benefit analysis on the expected benefits for science and society with direct consideration to the harm created to animals, a pilot study and a systematic review of previously published animal research on the topic, the availability of the appropriate facilities, equipment and expertise to guarantee high standards of animal accommodation, husbandry, care and use. The ethical documentation of a project by scientists themselvesinvolves team work and a sustainable rather than a one-off procedure. The ethical justification of the laboratory animal research protocols reflects the interest and the responsibility of scientists for reduction and refinement of animal experimentation. Thisprocess built a trust relationship between scientists and the society.
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7

Bryant, David H., Lynette M. Boscato, Paul N. Mboloi, and Margaret C. Stuart. "Allergy to laboratory animals among animal handlers." Medical Journal of Australia 163, no. 8 (October 1995): 415–18. http://dx.doi.org/10.5694/j.1326-5377.1995.tb124657.x.

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8

Shyan-Norwalt, Melissa R. "The human–animal bond with laboratory animals." Lab Animal 38, no. 4 (April 2009): 132–36. http://dx.doi.org/10.1038/laban0409-132.

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9

Swinbanks, David. "Laboratory animals unprotected." Nature 322, no. 6075 (July 1986): 103. http://dx.doi.org/10.1038/322103a0.

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10

McAllister Groves, Julian. "Are Smelly Animals Happy Animals? Competing Definitions of Laboratory Animal Cruelty and Public Policy." Society & Animals 2, no. 2 (1994): 125–44. http://dx.doi.org/10.1163/156853094x00144.

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AbstractRegulations surrounding laboratory animal care have tried to address aspects of an image of laboratory animal cruelty publicized by animal rights activists. This image of cruelty, however, is not consistent with the experiences of those charged with the day-to-day care of laboratory animals. This article examines the incongruities between the public image of cruelty to animals in laboratories as promoted by animal rights activists, and the experiences of laboratory animal care staff who apply and enforce laboratory animal care regulations. In doing so, the article illuminates why regulations surrounding laboratory animal care are difficult to comply with on the part of the policy enforcers, and are continuously contested by both animal rights activists and animal research personnel.
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11

von der Beck, Birte, Andreas Wissmann, Rene H. Tolba, Philip Dammann, and Gero Hilken. "What Can Laboratory Animal Facility Managers Do to Improve the Welfare of Laboratory Animals and Laboratory Animal Facility Staff? A German Perspective." Animals 14, no. 7 (April 8, 2024): 1136. http://dx.doi.org/10.3390/ani14071136.

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Laboratory animal facility managers must ensure that animal experiments can be carried out under optimal scientific conditions, that all legal requirements are met, and that animal welfare is maximized. Animal experimentation is stressful not only for the animals involved but also for the people who maintain these animals or carry out the experiments. Many of those involved find themselves in a constant conflict between scientific necessity, care, and harm. Under the term Culture of Care, procedures have been developed to reduce the burden of animal experimentation on the animals and the staff involved. The focus here is on what laboratory animal facility managers can do to improve the welfare of laboratory animals and the people working with them. Exemplary measures are the improvement of the housing conditions of laboratory animals, the introduction of uniform handling measures, clear and transparent structures via a quality management system, implementation of a no-blame culture of error (e.g., via Critical Incident Reporting System in Laboratory Animal Science [CIRS-LAS]), and open and respectful communication with all parties involved in animal experimentation, including the public and representatives of the authorities (public webpage, open house policy). The 6 Rs must be considered at all times: replacement, reduction, refinement, respect, responsibility, and reproducibility. We are writing this article from the perspective of laboratory animal facility managers in Germany.
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12

Held, Joe R. "Allergy to Animals: A Laboratory Animal Science Perspective." Allergy and Asthma Proceedings 8, no. 3 (May 1, 1987): 179–80. http://dx.doi.org/10.2500/108854187778984663.

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13

Semenov, D. A. "MODELS OF EXPERIMENTAL PLEURITE APPLICABLE ON LABORATORY ANIMALS." Amur Medical Journal, no. 3 (2017): 60–61. http://dx.doi.org/10.22448/amj.2017.3.60-61.

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14

Fox, Michael W. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409.c.

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15

Rosen, Deborah A. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409.d.

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16

Hubel, David H. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409.b.

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17

HUBEL, D. H. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409-a.

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18

Fox, M. W. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409-b.

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19

ROSEN, D. A. "Animals in the Laboratory." Science 244, no. 4903 (April 28, 1989): 409. http://dx.doi.org/10.1126/science.244.4903.409-c.

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20

Slovak, A. J., and A. J. Newman Taylor. "Allergy to laboratory animals." Occupational and Environmental Medicine 42, no. 3 (March 1, 1985): 213–14. http://dx.doi.org/10.1136/oem.42.3.213.

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21

Cooper, J. "Ethics and laboratory animals." Veterinary Record 116, no. 22 (June 1, 1985): 594–95. http://dx.doi.org/10.1136/vr.116.22.594.

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22

SHARPE, ROBERT. "Pain and laboratory animals." Nature 316, no. 6026 (July 1985): 290. http://dx.doi.org/10.1038/316290a0.

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23

MORTON, D. B. "Pain and laboratory animals." Nature 317, no. 6033 (September 1985): 106. http://dx.doi.org/10.1038/317106a0.

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24

Ishida, Y. "Laboratory animals and recognition." BMJ 305, no. 6853 (September 5, 1992): 589. http://dx.doi.org/10.1136/bmj.305.6853.589.

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25

Lebish, Irwin J., Arthur Hurvitz, Robert M. Lewis, Donald V. Cramer, and Steven Krakowka. "Immunopathology of Laboratory Animals." Toxicologic Pathology 14, no. 1 (January 1986): 129–34. http://dx.doi.org/10.1177/019262338601400116.

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26

Hauswald, Mark. "Use of laboratory animals." Lancet 353, no. 9168 (June 1999): 1977. http://dx.doi.org/10.1016/s0140-6736(05)77196-8.

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27

Morowitz, Harold J. "Laboratory Animals and Congress." Hospital Practice 27, no. 8 (August 15, 1992): 23–27. http://dx.doi.org/10.1080/21548331.1992.11705464.

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28

Kandpal, Diksha, Neha, and R. S. Chauhan. "Tumours in laboratory animals." Journal of Immunology and Immunopathology 20, si (2018): 87. http://dx.doi.org/10.5958/0973-9149.2018.00016.3.

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29

DeNardo, D. "Amphibians as Laboratory Animals." ILAR Journal 37, no. 4 (January 1, 1995): 173–81. http://dx.doi.org/10.1093/ilar.37.4.173.

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30

Jirkof, Paulin, Juliane Rudeck, and Lars Lewejohann. "Assessing Affective State in Laboratory Rodents to Promote Animal Welfare—What Is the Progress in Applied Refinement Research?" Animals 9, no. 12 (November 25, 2019): 1026. http://dx.doi.org/10.3390/ani9121026.

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An animal’s capacity to suffer is a prerequisite for any animal welfare concern, and the minimization of suffering is a key aim of refinement research. In contrast to the traditional focus on avoiding or reducing negative welfare states, modern animal welfare concepts highlight the importance of promoting positive welfare states in laboratory animals. Reliable assessments of affective states, as well as the knowledge of how to elicit positive affective states, are central to this concept. Important achievements have been made to assess pain and other negative affective states in animals in the last decades, but it is only recently that the neurobiology of positive emotions in humans and animals has been gaining more interest. Thereby, the need for promotion of positive affective states for laboratory animals is gaining more acceptance, and methods allowing the assessment of affective states in animals have been increasingly introduced. In this overview article, we present common and emerging methods to assess affective states in laboratory rodents. We focus on the implementation of these methods into applied refinement research to identify achieved progress as well as the future potential of these tools to improve animal welfare in animal-based research.
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31

Cassidy, Lauren, Stefan Treue, Alexander Gail, and Dana Pfefferle. "Choice-based severity scale (CSS): assessing the relative severity of procedures from a laboratory animal’s perspective." PeerJ 12 (June 17, 2024): e17300. http://dx.doi.org/10.7717/peerj.17300.

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One primary goal of laboratory animal welfare science is to provide a comprehensive severity assessment of the experimental and husbandry procedures or conditions these animals experience. The severity, or degree of suffering, of these conditions experienced by animals are typically scored based on anthropocentric assumptions. We propose to (a) assess an animal’s subjective experience of condition severity, and (b) not only rank but scale different conditions in relation to one another using choice-based preference testing. The Choice-based Severity Scale (CSS) utilizes animals’ relative preferences for different conditions, which are compared by how much reward is needed to outweigh the perceived severity of a given condition. Thus, this animal-centric approach provides a common scale for condition severity based on the animal’s perspective. To assess and test the CSS concept, we offered three opportunistically selected male rhesus macaques (Macaca mulatta) choices between two conditions: performing a cognitive task in a typical neuroscience laboratory setup (laboratory condition) versus the monkey’s home environment (cage condition). Our data show a shift in one individual’s preference for the cage condition to the laboratory condition when we changed the type of reward provided in the task. Two additional monkeys strongly preferred the cage condition over the laboratory condition, irrespective of reward amount and type. We tested the CSS concept further by showing that monkeys’ choices between tasks varying in trial duration can be influenced by the amount of reward provided. Altogether, the CSS concept is built upon laboratory animals’ subjective experiences and has the potential to de-anthropomorphize severity assessments, refine experimental protocols, and provide a common framework to assess animal welfare across different domains.
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32

Quimby, Fred W. "Twenty-five years of progress in laboratory animal science." Laboratory Animals 28, no. 2 (April 1, 1994): 158–71. http://dx.doi.org/10.1258/002367794780745335.

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During the past 25 years tremendous improvements have been made in the field of laboratory animal science. Refinements in genetic and microbial quality assurance and animal housing coupled with the development of professional expertise has contributed to enhanced animal well-being and a reduction in the variability of data collected from research animals. These advances occurred concomitant with an increased public awareness of research animal use. In 1967 Laboratory Animals Ltd. published the first issue of Laboratory Animals. In celebration of its Silver Jubilee, I will briefly highlight some of the changes which occurred in the field of laboratory animal science since 1967 and some of the medical advances which depended on animal-based research.
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33

Walvoort, H. C. "Contribution of pathology to laboratory animal welfare." Laboratory Animals 20, no. 4 (October 1, 1986): 291–92. http://dx.doi.org/10.1258/002367786780808839.

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To promote experimental animal welfare, several countries are engaged in establishing local animal research review committees and appointing supervising veterinarians or other experts. However, a number of adverse conditions leading to intercurrent illness or death remains unnoticed or unidentified. Pathological investigation of unexpectedly ill or dead animals proved to be very useful in indicating conditions compromising animal welfare. In addition, such post-mortem findings may be instructive, with respect to welfare, for those involved in experiments with animals.
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34

Manivannan, Rekha, Tamilselvan Chidambaram, Ramani Gopal, and King Solomon Ebenezer. "Microbial Diseases of Laboratory Animals and its monitoring Tools." Journal of Advances in Microbiology 24, no. 2 (February 21, 2024): 31–46. http://dx.doi.org/10.9734/jamb/2024/v24i2794.

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Microbial diseases pose significant challenges in experimental research, impacting both animal welfare and research outcomes. The review covers a wide range of microbial pathogens, including bacteria, viruses, fungi, and parasites, that commonly affect laboratory animals. It explores the etiology, pathogenesis, and clinical manifestations associated with these pathogens, highlighting their influence on experimental results. Extensively discussed about the monitoring assays employed for microbial disease detection in experimental animals. Traditional and modern techniques are considered, including microbiological culturing, serological assays, molecular diagnostics, histopathology, and advanced imaging methods. Regular health monitoring programs for laboratory animals, emphasizing the significance of early detection and intervention to prevent disease outbreaks and maintain animal welfare. Emerging trends and technologies in microbial disease monitoring, such as next-generation sequencing, metagenomics, and high-throughput screening, are also explored. This review aims to provide researchers, laboratory animal professionals, and regulatory authorities with a comprehensive resource for understanding microbial diseases in experimental animals and selecting appropriate monitoring assay. For the Scientists and Veterinarians this overall review gives a glimpse for implementing effective monitoring strategies, identifying and managing microbial diseases, ensuring the well-being of laboratory animals. The synthesis of current knowledge and best practices will enhance the scientific rigor and reproducibility of experimental studies involving animals. In conclusion, this review emphasizes the critical importance of microbial disease monitoring in experimental animals. Robust and accurate monitoring assays enable researchers to effectively detect and manage microbial diseases, safeguarding animal health and ensuring reliable research outcomes.
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35

Dovnar, R. I. "MODELING OF SKIN WOUNDS IN LABORATORY ANIMALS." Novosti Khirurgii 29, no. 4 (August 26, 2021): 480–89. http://dx.doi.org/10.18484/2305-0047.2021.4.480.

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The creation and implementation of new methods of study and local wound care occur in stages: in vitro, in vivo and clinical trials. The fundamental point of this process is to study the effect of the proposed agent on the experimental wound healing models of laboratory animals taking into consideration the common healing phases of course and similarity of animal wound healing with human one. At the initial stage the main problems faced by the researcher include the selection of the optimal experimental animal, while animal models are suitable for many skindisorders. The lack of strong evidence and relevant guidelines regarding the most appropriate form of local-wound care in literature and the fragmentation of the available information lead to the fact that during the development of the experiment, the scientists spend time, resources and operate on an additional number of animals. This article summarizes the literature data on the applied modeling methods as for the most common and rare types of skin wounds including burns and trophic ulcers in various laboratory animals. Those who prepared the experiment shouldhavepaidcloserattentionto thefeatures of creating such wounds and nuances so as the proven techniques of their creation in various species are shown. Variants of the course and prospects for the development of this area of surgery are presented.
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36

Wolfe, Mitchell, Neal D. Barnard, and Suzanne M. McCaffrey. "Animal Laboratory Exercises in Medical School Curricula." Alternatives to Laboratory Animals 24, no. 6 (December 1996): 953–56. http://dx.doi.org/10.1177/026119299602400610.

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The use of laboratory exercises involving animals in medical education is a subject of ongoing interest. Updated information is not often available, however, on the prevalence of such exercises or of alternatives to their use. In May 1994, a questionnaire on the use of animal laboratory exercises and suitable alternatives was sent to the chairpersons of the physiology, pharmacology and surgery departments of each of the 126 US medical schools. In comparison with earlier surveys, the information returned showed that the number of medical schools reporting the use of laboratory animals in physiology appears to have declined from over 50% to 41%, the number of schools reporting the use of laboratory animals in pharmacology courses appears to have declined from 25% to 16%, and the number of schools that reported the use of laboratory animals in surgery courses increased from around 20% to 30%. For the 53 schools that returned information from all three disciplines, 49% reported having no laboratory exercises involving animals in any of these disciplines. Computer programs and films were the most commonly used non-animal alternatives offered in physiology and pharmacology, while operating room experience was the most common alternative offered in surgery courses.
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37

Kim, KilSoo, Woori Jo, and Gwang-Hoon Lee. "Why do we always care about the welfare of laboratory animals?" Open Access Government 39, no. 1 (July 7, 2023): 518–19. http://dx.doi.org/10.56367/oag-36-10808.

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Why do we always care about the welfare of laboratory animals? Seasoned experts from the Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI hub) in South Korea share their research perspectives on the welfare of laboratory animals, including the issue of veterinary care. Awareness of animal ethics is changing and rising worldwide, and the concept of animal welfare importance is spreading rapidly. Generally, animal welfare involves not hurting, harassing or recklessly killing animals. In addition, animal welfare involves inducing positive changes in humans and animals, both physically and emotionally. Based on the research and discussion of Ruth Harrison’s claim in 1965, Britain began establishing various animal welfare measures. Subsequently, public opinion on animal welfare has spread widely across Europe.
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38

Druglitrø, Tone. "Writing Radical Laboratory Animal Histories." Nordic Journal of Science and Technology Studies 2, no. 1 (December 1, 2016): 36. http://dx.doi.org/10.5324/njsts.v2i1.2135.

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<div>In recent years historians have called for a radical historicizing to broaden the perspectives, stories and actors that are usually made subjects of historical investigations. The appeals have mainly come from scholars that have been concerned with historicizing nature and human-nature relations. But what does radical historicizing entail and why do we need it? The article presents a reflexive review of current methods and perspectives in the social sciences and humanities that have affected my own engagement with the history of laboratory animals in Norway. It presents an argument for doing historiography that reflects contemporary scholarly concerns on representation. Rather than seeking to “give animals histories of their own” I propose that radical historicizing should include writing histories of the entanglement and disentanglement of humans and other things and beings. This does not then involve a shift to writing animal stories for the sake of animals, but to write stories where humans and animals are considered mutually shaped and affected by each other, and how these interactions have world-transforming effects.</div>
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39

Moriwaki, Kazuo. "Laboratory Animals in Genome Age." TRENDS IN THE SCIENCES 7, no. 9 (2002): 39–41. http://dx.doi.org/10.5363/tits.7.9_39.

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40

Niemi, Steven M. "Laboratory animals as veterinary patients." Journal of the American Veterinary Medical Association 242, no. 8 (April 15, 2013): 1063–65. http://dx.doi.org/10.2460/javma.242.8.1063.

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41

Gordon, Susan. "Occupational sensitization to laboratory animals." Clinical & Experimental Allergy 27, no. 6 (June 1997): 603–5. http://dx.doi.org/10.1111/j.1365-2222.1997.tb01186.x.

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42

GORDON, SUSAN. "Occupational sensitization to laboratory animals." Clinical Experimental Allergy 27, no. 6 (June 1997): 603–5. http://dx.doi.org/10.1046/j.1365-2222.1997.d01-547.x.

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43

Bomzon, Arieh. "Case Reports for Laboratory Animals." Laboratory Animals 50, no. 5 (September 26, 2016): 404. http://dx.doi.org/10.1177/0023677216669094.

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44

Hansen, Axel Kornerup, and Craig Franklin. "Microbiota, laboratory animals, and research." Laboratory Animals 53, no. 3 (May 17, 2019): 229–31. http://dx.doi.org/10.1177/0023677219844538.

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45

Rice, Andrew-Sven. "Modeling Pain in Laboratory Animals." Clinical Journal of Pain 28, no. 1 (January 2012): 92. http://dx.doi.org/10.1097/ajp.0b013e3182201a34.

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46

ISA, Tadashi, Itaru YAMANE, Miya HAMAI, and Haruhisa INAGAKI. "Japanese Macaques as Laboratory Animals." Experimental Animals 58, no. 5 (2009): 451–57. http://dx.doi.org/10.1538/expanim.58.451.

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47

Wenz, Charles. "An ombudsman for laboratory animals?" Nature 320, no. 6062 (April 1986): 475. http://dx.doi.org/10.1038/320475b0.

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48

Clarke, Maxine. "UK laboratory animals: Experimentation reduced." Nature 316, no. 6026 (July 1985): 286. http://dx.doi.org/10.1038/316286a0.

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49

Clarke, Maxine. "UK laboratory animals: Experimentation reduced." Nature 316, no. 6026 (July 1985): 286. http://dx.doi.org/10.1038/316286c0.

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50

Carbone, Larry, Luce Guanzini, and Cary McDonald. "Adoption Options for Laboratory Animals." Lab Animal 32, no. 9 (October 2003): 37–41. http://dx.doi.org/10.1038/laban1003-37.

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