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Relevant bibliographies by topics / Lactam Based Molecules

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Academic literature on the topic 'Lactam Based Molecules'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "Lactam Based Molecules"

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Bai, Yuchen, Leina Dou, Weilin Wu та ін. "Anti-Metatype Antibody Screening, Sandwich Immunoassay Development, and Structural Insights for β-Lactams Based on Penicillin Binding Protein". Molecules 26, № 18 (2021): 5569. http://dx.doi.org/10.3390/molecules26185569.

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Theoretically, sandwich immunoassay is more sensitive and has a wider working range than that of competitive format. However, it has been thought that small molecules cannot be detected by the sandwich format due to their limited size. In the present study, we proposed a novel strategy for achieving sandwich immunoassay of β-lactams with low molecular weights. Firstly, five β-lactam antibiotics were selected to bind with penicillin binding protein (PBP)2x* to form complexes. Then, monoclonal and polyclonal antibodies against PBP2x*-β-lactams complexes were produced by animal immunization. Subs

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Becker, D., M. Botoshansky, N. Gasper, F. H. Herbstein, and M. Karni. "2-Phenyl-4-hydroxyphthalazin-1-one: A Benzoannelated Derivative of Maleic Hydrazide." Acta Crystallographica Section B Structural Science 54, no. 5 (1998): 671–76. http://dx.doi.org/10.1107/s0108768197015760.

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The monoclinic crystals (space group P21/a, Z = 8) of 2-phenyl-4-hydroxyphthalazin-1-one, C14H10N2O2, have two independent molecules (A and B) in the asymmetric unit. Both occur as the lactim–lactam (hydroxy–one) structure, which is also found in the parent molecule maleic hydrazide (both triclinic and monoclinic polymorphs), dichloromaleic hydrazide and luminol (3-aminophthalhydrazide). The molecular arrangement is based on strings of alternating A and B molecules linked by hydroxyl...carbonyl hydrogen bonds, with only van der Waals interactions between adjacent strings. Comparison is made of

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Cox, Robin A. "Lactams in sulfuric acid. The mechanism of amide hydrolysis in weak to moderately strong aqueous mineral acid media." Canadian Journal of Chemistry 76, no. 6 (1998): 649–56. http://dx.doi.org/10.1139/v98-012.

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Reaction rate constants obtained in moderately concentrated sulfuric acid for the hydrolysis of simple lactams of ring sizes five, six, seven, and eight as a function of acidity and temperature have been analyzed using the excess acidity kinetic method. The basicity constants for these substrates have been recalculated; the 13C NMR spectra used to obtain these values are very sensitive to medium effects. It was found that the basicities of the lactams at 0.003-0.1 M lactam concentration were over half a pK unit more basic than they were at 0.5 M lactam, presumably because of the medium effect.

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Pestana-Nobles, Roberto, Yani Aranguren-Díaz, Elwi Machado-Sierra, et al. "Docking and Molecular Dynamic of Microalgae Compounds as Potential Inhibitors of Beta-Lactamase." International Journal of Molecular Sciences 23, no. 3 (2022): 1630. http://dx.doi.org/10.3390/ijms23031630.

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Bacterial resistance is responsible for a wide variety of health problems, both in children and adults. The persistence of symptoms and infections are mainly treated with β-lactam antibiotics. The increasing resistance to those antibiotics by bacterial pathogens generated the emergence of extended-spectrum β-lactamases (ESBLs), an actual public health problem. This is due to rapid mutations of bacteria when exposed to antibiotics. In this case, β-lactamases are enzymes used by bacteria to hydrolyze the beta-lactam rings present in the antibiotics. Therefore, it was necessary to explore novel m

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Molteni, Elena, Giovanni Onida, Matteo Ceccarelli, and Giancarlo Cappellini. "Ab Initio Spectroscopic Investigation of Pharmacologically Relevant Chiral Molecules: The Cases of Avibactam, Cephems, and Idelalisib as Benchmarks for Antibiotics and Anticancer Drugs." Symmetry 13, no. 4 (2021): 601. http://dx.doi.org/10.3390/sym13040601.

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The ability to accurately measure or predict several physicochemical properties of molecules which play a role as active substances in drugs can be of strategic importance for pharmacological applications, in addition to its possible interest in fundamental research. Chirality is a relevant feature in the characterization of drug molecules: enantiomers can show different pharmacological activity and adverse effects. The ability to separate stereoisomers and to assign their absolute configuration can thus be crucial. Circular dichroism (CD) spectra are a useful tool to distinguish between enant

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Twamley, Brendan, Niamh M. O'Boyle, and Mary J. Meegan. "Azetidin-2-ones: structures of antimitotic compounds based on the 1-(3,4,5-trimethoxyphenyl)azetidin-2-one core." Acta Crystallographica Section E Crystallographic Communications 76, no. 8 (2020): 1187–94. http://dx.doi.org/10.1107/s2056989020008555.

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A series of related substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones have been characterized: 3-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C25H24FNO5 (1), 3-(furan-2-yl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C23H23NO6 (2), 4-(4-methoxyphenyl)-3-(naphthalen-1-yl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C29H27NO5 (3), 3-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C27H29NO7 (4) and 4,4-bis(4-methoxyphenyl)-3-phenyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C32H31NO6 (5). All of the compounds

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Shiri, Pezhman. "Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents". Mini-Reviews in Medicinal Chemistry 21, № 5 (2021): 536–53. http://dx.doi.org/10.2174/18755607mtewaotyn5.

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Kurmaz, Svetlana V., Natalia V. Fadeeva, Vladislav M. Ignat’ev, Vladimir A. Kurmaz, Sergei A. Kurochkin, and Nina S. Emel’yanova. "Structure and State of Water in Branched N-Vinylpyrrolidone Copolymers as Carriers of a Hydrophilic Biologically Active Compound." Molecules 25, no. 24 (2020): 6015. http://dx.doi.org/10.3390/molecules25246015.

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Hydrated copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate as a promising platform for biologically active compounds (BAC) were investigated by different physical chemical methods (dynamic light scattering, infrared spectroscopy, thermal gravimetric analysis, and differential scanning calorimetry) and the quantum chemical modeling of water coordination by the copolymers in a solution. According to the quantum chemical simulation, one to two water molecules can coordinate on one O-atom of the lactam ring of VP units in the copolymer. Besides the usual terminal coordin

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Shlaes, D. M., та C. Currie-McCumber. "Mutations altering substrate specificity in OHIO-1, and SHV-1 family β-lactamase". Biochemical Journal 284, № 2 (1992): 411–15. http://dx.doi.org/10.1042/bj2840411.

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The OHIO-1 beta-lactamase does not normally hydrolyse oxyimino-beta-lactam substrates like cefotaxime, ceftriaxone, ceftazidime or aztreonam. We were able to select spontaneous mutants of an OHIO-1-bearing strain of Escherichia coli using the antibiotic substrates listed above by enrichment methods of frequencies of 10(-8)-10(-10) for all antibiotics except ceftazidime (frequency less than 10(-10)). Most mutants with increased resistance to the other beta-lactams were also more resistant to ceftazidime. Mutations identified by DNA sequencing included a Gly238----Ser238 substitution identical w

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Maity, Arindam, Sarmi Sardar, Shilpa Chatterjee, Nripendra Nath Bala, Sudhan Debnath та Debanjan Sen. "De-Novo Design of Hits Against New Delhi Metallo-β-Lactamase Enzyme". International Journal of Quantitative Structure-Property Relationships 7, № 2 (2022): 1–13. http://dx.doi.org/10.4018/ijqspr.290010.

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The New Delhi Metallo-β-lactamase 1 (NDM-1) is a class of Metallo-β lactamase enzyme. It is responsible for hydrolyzing almost all β-lactam antibiotics, leading to multi-drug resistance in bacteria. The lack of specific therapeutic options against this target creates an emerging need to develop new molecules against it. The multistep fragment- and knowledge-based de-novo design methods were considered for this study to design small molecules. The designed molecules were evaluated by molecular docking and dynamics simulation, followed by drug-likeness prediction. This study reports that a new d

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Dissertations / Theses on the topic "Lactam Based Molecules"

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Divse, J. M. "Design and synthesis of novel bioactive steroids and beta - lactam based molecules by click chemistry and application of steroidal organocatalyst for aldol reaction." Thesis(Ph.D.), CSIR- National Chemical Laboratory, Pune, 2017. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4345.

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Nichols, Derek Allen. "Structure-Based Design of Novel Inhibitors and Ultra High Resolution Analysis of CTX-M Beta-Lactamase." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5284.

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The emergence of CTX-M class-A extended-spectrum β-lactamases, which confer resistance to second and third-generation cephalosporins, poses a serious health threat to the public. CTX-M β-lactamases use a catalytic serine to hydrolyze the β-lactam ring. Specifically, the hydrolysis reaction catalyzed by CTX-M β-lactamase proceeds through a pre-covalent complex, a high-energy tetrahedral acylation intermediate, a low-energy acyl-enzyme complex, a high-energy tetrahedral deacylation intermediate after attack via a catalytic water, and lastly, the hydrolyzed β-lactam ring product which is released

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Chien-Hsien, Kuo. "Molecular phylogeny and evolution of hagfish based on mtDNA and lactate dehydrogenase genes." 2000. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0021-2603200719104655.

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Kuo, Chien-Hsien, and 郭建賢. "Molecular phylogeny and evolution of hagfish based on mtDNA and lactate dehydrogenase genes." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/03269412909281228290.

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博士<br>國立臺灣師範大學<br>生物研究所<br>89<br>Abstracts The study included molecular phylogeny of hagfish and evolution of lactate dehydrogenase. The mitochondrial DNA sequences from the large ribosomal RNA gene may be of great value for systematic and phylogenetic studies within families. Partial sequences of the 16S rRNA gene were obtained for comparisons among the following hagfish species, Paramyxine nelsoni, P. sheni, P. taiwanae, P. yangi, P. cheni, Eptatretus burgeri, E. stouii, E. cirrhatus, Myxine glutinosa, M. formosana, M. circifrons, M. sp1 and M. sp2. The boundary of first four Para

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Barbosa, João Alberto Cunha. "Development of a poly(L-Lactic acid) based drug release system." Master's thesis, 2015. http://hdl.handle.net/1822/41125.

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Dissertação de mestrado em Biofísica e Bionanossistemas<br>Nanomedicine and controllable drug delivery systems have recently initiated their way into therapeutics. Faulty and, many times, ineffective approaches that conventional medicine uses need to be replaced by novel and smart materials that assure that a drug is delivered in the right place, at the right time. Polymeric materials are now widely used to produce drug delivery vehicles with tunable characteristics and, if needed, triggered releases. Although several polymeric materials are already being used to produce drug delivery sys

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Book chapters on the topic "Lactam Based Molecules"

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Delpiccolo, Carina M. L., Maitena Martinez-Amezaga, and Ernesto G. Mata. "Recent Approaches Toward the Generation of Molecular Diversity Based on β-Lactam Structures." In Beta-Lactams. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55621-5_5.

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Barber, Michael S., Ulrich Giesecke, Arno Reichert, and Wolfgang Minas. "Industrial Enzymatic Production of Cephalosporin-Based β-Lactams." In Molecular Biotechnolgy of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b99261.

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Coelho-Rocha, Nina D., Fernanda A. L. Barroso, Laísa M. Tavares, et al. "Main Features of DNA-Based Vectors for Use in Lactic Acid and Update Protocols." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0872-2_16.

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Tuzar, Zdeněk. "Molecular Characterization." In Lactam-Based Polyamides. CRC Press, 2019. http://dx.doi.org/10.1201/9780367813062-4.

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N. Akila, Dr. "FERMENTATION TECHNOLOGY." In Futuristic Trends in Biotechnology Volume 3 Book 2. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bgbt2p1ch7.

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Fermentation is a complex process that involves molecular oxidation or reduction mechanisms driven by selective microorganisms under anaerobic conditions. This transformative process results in the production of various bioactive molecules, which offer significant health benefits. The fundamental principle of fermentation technology entails cultivating organisms under ideal conditions, providing them with essential raw materials like carbon, nitrogen, salts, trace elements, and vitamins. The primary function of fermentation lies in the conversion of NADH back into the coenzyme NAD+, allowing i

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Le Rouzic, Morgan, Pauline Bruniaux, Cyril Raveschot, et al. "Lactobacillus Use for Plant Fermentation: New Ways for Plant-Based Product Valorization." In Lactobacillus - A Multifunctional Genus [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104958.

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Today, plant production is increasing, but most industrial processes generate a lot of waste and by-products for which, in the current context, it is a priority to recycle or valorize them. One of the cheapest valorization routes is fermentation, in particular lactic fermentation by Lactobacillus species, which produces lactic acid and other molecules of industrial interest such as bioactive compounds such as anthocyanin, organic acid, peptides, or phenol, which are widely found in the plant matrix, mainly in cereals, grass, fruits, and vegetables. Bioactive compounds may exert beneficial heal

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Beneke Ralph. "Ventilatory Thresholds, Lactic Thresholds and Maximal Lactate Steady State Concept." In Biomedical and Health Research. IOS Press, 2010. https://doi.org/10.3233/978-1-60750-497-9-299.

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More than 200 years ago lactate and oxygen had been identified as important chemical components and shortly later they were linked with metabolism and physical activity. Compared to these roots, threshold concepts as measures of aerobic fitness are relative recent developments invented during the second half of the last century. All thresholds are based on specific patterns of individual or combined increases in measures such as lactate, oxygen uptake, carbon dioxide production and ventilation during exercise tests with an increasing workload. Thresholds are supposed to identify objectively th

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Zong, Liang, Jingning Zhang, Dan Li, et al. "A Rhodamine-Based Probe for Detection of Nerve Agents Simulants." In Advances in Transdisciplinary Engineering. IOS Press, 2021. http://dx.doi.org/10.3233/atde210333.

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In this paper, a rhodamine-based fluorescent and chromogenic probe, N-(Rhodamine B)-lactam-2-aminobenzyl alcohol (RB-AB), was designed to detect nerve agent simulants. We firstly synthesized RB-AB probe by using rhodamine B and 2-aminobenzyl alcohol as main materials. Secondly, the RB-AB probe was applied to evaluate its ability to detect two nerve agent simulants, diethyl chloride phosphate (DCP) and methyl ethyl chloride phosphate (MECP). It was assumed that RB-AB could react with the nerve agent simulants through the benzyl alcohol group and then undergoes structural changes. As a result, t

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Dinodia, Monica. "Greener Approach towards the Synthesis of Nitrogen Based Heterocycles." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108489.

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The preferable application of green chemistry in research is to utilize environment benign, mild, non toxic, reproducible catalyst and efficient solvents in synthesis of molecules. Use of green chemistry techniques had enabled in dramatically reducing chemical waste and reaction times as has recently been reported in several organic syntheses reactions. Greener routes are required in the synthesis of N-heterocycles, due to the remarkable importance of these compounds in medicinal chemistry. This chapter is dedicated to the synthesis of N containing heterocyclic compounds using eco-friendly sol

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Bhukya, Bhima, Chandrasekhar Banoth, Praveen K. Keshav, MD Saddam Hussain, and Shanthipriya Ajmera. "Biotechnological Production of Various Fungal Metabolites and their Applications in White Biotechnology." In Mycology: Current and Future Developments. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040340122040019.

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The rapid growth of science and technology resulted in an increase in the production and utilization of chemical-based value-added compounds. Due to the involvement of greenhouse gases and global warming, there is a shift towards alternative strategies to replace chemical-based value-added products. Primary and secondary metabolites produced by various microorganisms could be an effective and environmentally friendly alternative to chemically manufactured value-added products. Metabolites produced from various fungal strains (filamentous fungi and yeast) are of high importance for their widesp

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Conference papers on the topic "Lactam Based Molecules"

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Rob, Mohammad A., and Frank C. Franceschetti. "Atmospheric Multi-Component Pollution Analysis Using CO2 Laser." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1992. http://dx.doi.org/10.1364/laca.1992.wc7.

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The laser spectroscopic techniques for detecting minor gaseous pollutants of the atmosphere have made rapid advances in the last few years. The most important optical process for detection of air pollutants is based on the extinction of radiation by molecular absorption. Each molecule absorbs light at a particular wavelength or a range of wavelengths, a characteristic of the molecule. Thus a measurement of absorption of light at the molecule's characteristic wavelength produces a mean of determining a particular molecule at the presence of other molecules. Problems can, and often arise from ov

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Hill, S. C., M. D. Barnes, W. B. Whitten, and J. M. Ramsey. "Modeling Fluorescence Collection from Single Molecules in Liquid Microspheres." In Laser Applications to Chemical and Environmental Analysis. Optica Publishing Group, 1996. http://dx.doi.org/10.1364/lacea.1996.lwd.7.

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Optimization of molecular detection efficiencies is of central importance in analytical applications involving single molecule detection.1 In addition to limitations imposed on the fraction of molecules which can be detected by the average signal-to-noise ratio, experimental factors such as excitation inhomogeneity and molecular diffusion conspire to further limit "molecular detectability." Recent single molecule detection experiments in microdroplets suggest that such experimental limitations can be significantly reduced primarily because the molecule cannot diffuse away from the excitation v

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Lermer, N., M. D. Barnes, C.-Y. Kung, W. B. Whitten, and J. M. Ramsey. "High-Speed Single Molecule Detection in Microdroplet Streams." In Laser Applications to Chemical and Environmental Analysis. Optica Publishing Group, 1996. http://dx.doi.org/10.1364/lacea.1996.lwb.7.

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The detection of individual fluorescent molecules in liquids has been of great interest in recent years. Various fluorescence-based techniques shown to provide single molecule sensitivities include confocal microscopy [1], flow cell techniques [2], and levitated microdroplets [3]. The application of the microdroplet technique to single molecule detection offers many advantages. First, fluoresence decay rates and total fluoresence yield have been shown to be enhanced in glycerol microdroplets [4]. Additionally, the droplet confines the single fluorophore to a small volume thereby removing diffi

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Willey, K. F., V. Vorsa, and N. Winograd. "Molecular Photoionization and Chemical Imaging." In Laser Applications to Chemical and Environmental Analysis. Optica Publishing Group, 1998. http://dx.doi.org/10.1364/lacea.1998.ltub.4.

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It is now possible to desorb a variety of organic molecules from surfaces using a tightly focused energetic ion beam. The molecules are detected as secondary ions using time-of-flight mass spectrometry, and may be spatially resolved by rastoring the ion beam over a larger area. A chemically resolved image is then acquired by examining the intensity of a particular mass as a function of x,y position. Presently, liquid metal ion sources using 25 KeV Ga+ ion projectiles can be focused to a spot of less than 20 nm in diameter. The limiting factor for molecule-specific imaging is sensitivity. The i

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Terekhova, M. I., E. V. Rogacheva, I. A. Derevyanchenko, and L. A. Kraeva. "WHOLE-GENOME SEQUENCING-BASED ANTIBIOTIC RESISTANCE PROFILE OF LISTERIA MONOCYTOGENES STRAINS FROM SAINT-PETERSBURG AND THE VOLOGDA REGION." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-109.

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The increasing number of antibiotic-resistant isolates of L. monocytogenes is required to establish a genotypic resistance profile to ensure appropriate antibiotic therapy of listeriosis. In this study, whole-genome sequencing and de novo assembly was performed on L. monocytogenes strains from St. Petersburg and the Vologda region. We obtained the MLST ST, phylogenetic lineage and PCR-serogroups in silico for isolates under the study, revealed genes and mutations associated with antibiotic resistance. In general, the genetic composition was similar between the strains from different regions an

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Dovichi, Norman J., Shade Wu, and Da Yung Chen. "High Sensitivity Fluorescence Detection of Biological Molecules." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/laca.1990.tha1.

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Fluorescein is a good fluorescent label for high sensitivity analysis. The molecule has high molar absorptivity, 5 × 104 L mol-1 cm-1 at 488 nm and near unit fluorescence quantum yield in the pH range of 8 to 10. Unfortunately, the molecule is not photostable undergoing irreversible photobleaching after absorbance of about 8,000 photons. Fluorescein may be used to label amino groups in amino acids, peptides, and proteins through the isothiocyanate derivative. Under basic conditions, the thiocarbamoyl derivative is formed, with relatively good stability. The reaction between amino acids and flu

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Yeung, Edward S. "Laser Based Analytical Measurements In Liquids." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.ma4.

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The use of lasers for detection in liquid chromatography (LC) has been gaining in popularity. The reason is that unique properties of the laser beam fit well with many of the requirements in LC. Fluorescence is one of the widely used laser-based techniques. However, one is often limited by the availability of a fluorophore, the availability of the appropriate laser wavelength, and the poor intensity stability of lasers. A possible solution is to use indirect fluorometry. Because there is always a solvent present in LC, one can include a fluorescent probe in the solvent. There is then a large b

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Jett, James H., Lloyd C. Davis, Jong Hoon Hahn, et al. "Single Molecule Detection in Flowing Sample Streams As An Approach to DNA Sequencing." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/laca.1990.tha3.

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We are exploring a technique which has the potential to sequence large fragments of DNA at a rate of hundreds of bases per second. Our technique is based upon a projected ability to detect single chromophores by laser-induced fluorescence in flowing sample streams.1 The technique involves: (1) labeling the nucleotides with base specific tags suitable for fluorescence detection, (2) selecting a desired fragment of DNA, (3) suspending the single DNA fragment in a flowing sample stream, (4) sequentially cleaving labeled bases from the free end of the DNA fragment using an exonuclease, and (5) det

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Kudo, Hiroyuki, Yusuke Suzuki, Yoshiki Tojo, Haruna Saito, and Keigo Enomoto. "Sweat Lactic Acid Monitoring System using Adhesive Plaster-based Sweat Sampling Device." In 2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2019. http://dx.doi.org/10.1109/nems.2019.8915655.

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Hieftje, Gary M. "New Laser-Based Measurements in Analytical Spectrometry: From Remote Testing to Thomson Scattering." In Laser Applications to Chemical Analysis. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/laca.1987.ma5.

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In this presentation, several laser-based procedures and techniques for measuring chemical substances and for characterizing chemical instrumentation will be described. However, greatest emphasis will be placed on describing some new methods for determining the time-dependent characterics of molecules in condensed phase.

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Reports on the topic "Lactam Based Molecules"

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Velghe, Ineke, Bart Buffel, Veerle Vandeginste, Wim Thielemans, and Frederik Desplentere. Modelling hydrolytic, thermal, and mechanical degradation of PLA during single-screw extrusion. Universidad de los Andes, 2024. https://doi.org/10.51573/andes.pps39.ss.dbc.1.

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Since melt processing causes degradation of poly(lactic acid) or PLA, it is crucial to understand the effect of extrusion conditions on the molecular weight reduction. Kinetic models found in literature are promising tools to describe hydrolytic, thermal, and mechanical degradation during extrusion. In order to use these models, extrusion parameters (that are equipment dependent) should be translated into the four fundamental parameters that determine degradation: moisture content in PLA, residence time, shear stress history and temperature history. This work presents a methodology to use nume

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