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1

Briggs, Gerald G. Drugs in lactation. 2nd ed. Baltimore: Williams & Wilkins, 1997.

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2

1935-, Freeman Roger K., and Yaffe Sumner J. 1923-, eds. Drugs in Pregnancy and Lactation. 7th ed. Baltimore: Lippincott Williams & Wilkins, 2005.

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3

Program, Motherisk, ed. Cancer in pregnancy and lactation: The Motherisk guide. Cambridge, UK: Cambridge University Press, 2011.

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4

Briggs, Gerald G. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 3rd ed. Baltimore: Williams & Wilkins, 1990.

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5

1935-, Freeman Roger K., and Yaffe Sumner J. 1923-, eds. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 6th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2002.

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6

G, Briggs Gerald, Nageotte Michael P, and American Society of Health-System Pharmacists., eds. Diseases, complications, and drug therapy in obstetrics: A guide for clinicians. Bethesda, Md: American Society of Health-System Pharmacists, 2009.

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7

Briggs, Gerald G. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk on CD-ROM. [Philadelphia, Pa.]: Lippincott, Williams & Wilkins, 1999.

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8

Hale, Thomas Wright. Medications and mothers' milk. Amarillo, TX: Pharmasoft Medical Pub., 2004.

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9

Hale, Thomas Wright. Medications and mothers' milk. Amarillo, TX: Pharmasoft Medical Publishing, 2002.

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10

Medications and mothers' milk. 4th ed. Amarillo, Tex: Pharmasoft Medical Publishing, 1995.

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11

C, Petersen Robert, Moore Dorothy Tuell, Haase Tineke Boddé, and United States. Alcohol, Drug Abuse, and Mental Health Administration. Office for Substance Abuse Prevention., eds. Alcohol, tobacco, and other drugs may harm the unborn. Rockville, MD: U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Office for Substance Abuse Prevention, 1990.

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12

Cook, Paddy Shannon. Alcohol, tobacco, and other drugs may harm the unborn. Rockville, MD (Rockwall II, 5600 Fishers Lane, Rockville 20857): U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Office for Substance Abuse Prevention, 1990.

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13

Cook, Paddy Shannon. Alcohol, tobacco, and other drugs may harm the unborn. Rockville, MD: U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Office for Substance Abuse Prevention, 1990.

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14

Cook, Paddy Shannon. Alcohol, tobacco, and other drugs may harm the unborn. Rockville, MD: U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, Office for Substance Abuse Prevention, 1990.

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15

Weiner, Carl P. Drugs for pregnant and lactating women. New York: Churchill Livingstone, 2004.

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16

Catalin, Buhimschi, ed. Drugs for pregnant and lactating women. 2nd ed. Philadelphia: Saunders/Elsevier, 2010.

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17

Drugs in Pregnancy and Lactation. Lippincott Williams & Wilkins, 2011.

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18

1963-, Lee Anne, Inch Sally 1951-, and Finnigan David, eds. Therapeutics in pregnancy and lactation. Abingdon, Oxon: Radcliffe Medical Press, 2000.

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19

Lee, Anne. Therapeutics in Pregnancy And Lactation. Radcliffe Medical Press, 2006.

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20

Kraemer, Oliver, and Timothée Fraisse. Drugs in pregnancy and lactation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0011.

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Medical or surgical interventions, requiring anaesthesia and/or analgesia, are frequent during various stages of pregnancy and lactation when the mother, the embryo/fetus, and the breastfeeding infant are vulnerable. Many physiological alterations occur during pregnancy, which might result in modified pharmacokinetic/pharmacodynamic drug profiles. These are often challenging situations for the treating physician who has to rely on scarce clinical or epidemiological data to support their prescriptions. This chapter reviews the underlying principles of pharmacology and related toxicity during pregnancy and lactation. It outlines current recommendations for most commonly used drugs in anaesthesia (i.e. local anaesthetics, hypnotics, opioids, and muscle relaxants) and pain relief (i.e. analgesics and anti-inflammatory drugs). It should not be considered as an exhaustive description of the potential side effects nor should it be used as a prescription guide for specific clinical situations. When administering drugs to pregnant or lactating women, one should always refer to up-to-date best standard of care and review references, which should be clearly documented in the patient’s medical record, especially with respect to newly marketed compounds.
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21

A, Berrebi, ed. Guide des médicaments anti-infectieux lors de la grossesse et de l'allaitement. Rueil-Malmaison: Doin, 2003.

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22

Christof, Schaefer, Peters P. W. J, and Miller Richard K. 1946-, eds. Drugs during pregnancy and lactation: Treatment options and risk assessment. 2nd ed. Amsterdam: Elsevier Academic Press, 2007.

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23

Miller, Richard K., Christof Schaefer, and Paul W. J. Peters. Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. Elsevier Science & Technology Books, 2014.

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24

Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 7th ed. Lippincott Williams & Wilkins, 2005.

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25

N, Bennett P., and World Health Organization. Regional Office for Europe., eds. Drugs and human lactation: A guide to the content and consequences of drugs, micronutrients, radiopharmaceuticals, and environmental and occupational chemicals in human milk. Amsterdam: Elsevier, 1988.

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26

Hale, Thomas Wright. Medications and mothers' milk. 2012.

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27

N, Bennett P., and Jensen Allan A, eds. Drugs and human lactation: A comprehensive guide to the content and consequences of drugs, micronutrients, radiopharmaceuticals, and environmental and occupational chemicals in human milk. 2nd ed. Amsterdam: Elsevier, 1996.

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28

Medications & Mothers' Milk: 2019. Springer Publishing Company, Incorporated, 2017.

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29

Ainsworth, Sean. Neonatal Formulary. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198840787.001.0001.

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Neonatal Formulary bridges a gap between a standard formulary (stating doses, indications, etc.) and a standard neonatal textbook by expanding information about the conditions for which each drug is used. Much of drug use during pregnancy, lactation, and in neonates and young infants is ‘off license’ (i.e. using licensed drugs but for an indication that is outside the licensed use—in many cases simply because the studies and the licensing application did not include data about neonatal use). The book offers information to allow practitioners to make informed choices whether to use such a drug or not by presenting data from published studies to support such a use. Part 1 concentrates on drug prescribing and drug administration, presenting general information on drug storage, drug licensing, and drug prescribing. It also explains to the reader why the metabolism of drugs differs in premature and sick infants and why the practice of extrapolating doses from adult studies is wrong. Patient safety, excipients, and therapies that affect drug metabolism (such as therapeutic hypothermia) are also covered. Part 2 consists of drug monographs for over 250 drugs that may find use in the neonatal population but which nonetheless may also find use outside the neonatal unit. Each monograph is divided into sections covering use, pharmacology, treatment, drug interactions, or other administration information, supply, and administration, and references. The monographs also contain links to Cochrane Database of Systematic Reviews and national guidelines supported by bodies such as the National Institute for Health and Care Excellence or the Royal Colleges. Part 3 contains brief notes on a range of additional drugs and groups of drugs that are often taken by mothers during pregnancy, labour, or during breast feeding where effects on either the fetus or infant can be seen. This information will help to provide safe and effective prescribing of drugs to all mothers and their babies.
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30

Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk (Drugs in Pregnancy and Lactation). 8th ed. Lippincott Williams & Wilkins, 2008.

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31

Weiner, Carl, and Catalin Buhimschi. Drugs for Pregnant and Lactating Women. Churchill Livingstone, 2003.

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32

Marshall, Tarnya, Rita Abdulkader, and Poonam Sharma. Antirheumatic drugs in pregnancy and lactation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0097_update_003.

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Antirheumatic drugs in pregnancy and lactation are increasingly a common clinical dilemma. With the shift towards early, aggressive control of autoimmune diseases and with the advent of newer therapeutic agents, there is a need to understand the effects of these medicines in pregnancy and lactation, on fertility in both men and women, and on the process of spermatogenesis, in order to understand the risk of teratogenesis. Although there are some limited data available for the use of antirheumatic drugs in pregnancy and lactation, much of our knowledge is derived from animal models and from limited clinical experience in human pregnancy. The balance of therapeutic benefits and risks of harm to mother and fetus should always be carefully considered: it may vary between individuals and should be assessed on a case by case basis. Because of these issues, pregnancy should always be discussed and planned in advance, in part to reduce disease activity prior to conception but also to minimize risk to the fetus. In this chapter we use the available evidence to discuss medicines which are commonly used in the treatment of rheumatological autoimmune diseases, and cover disease-modifying antirheumatic drugs (DMARDS) and biological agents.
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33

Drugs for Pregnant and Lactating Women. Elsevier - Health Sciences Division, 2018.

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34

Lynch, Tara A., and J. Christopher Glantz. Seizure Medications Effects on Fetus, Neonate, and Lactation. Edited by Emma Ciafaloni, Cheryl Bushnell, and Loralei L. Thornburg. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0021.

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Medication use in pregnancy requires a careful balance between the risks of fetal teratogenicity and the maternal benefits of disease treatment. For women with epilepsy, there are many antiepileptic medications available for use in pregnancy. Each varies in their safety profile, risk for fetal anomalies, and effectiveness of seizure control. In most scenarios, the benefits of maternal treatment outweigh the risk of fetal effects, especially in cases of refractory epilepsy or severe disease. Many of the newer anti-epileptic drugs appear to have less teratogenic risk than the older medications. The ideal AED is one that is effective from the woman, is least teratogenic, and used at the lowest possible dose. Overall, a detailed understanding of antiepileptic efficacy, the pharmacologic differences in pregnancy, and the potential adverse fetal effects are required for optimal treatment of pregnant patients with epilepsy.
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35

Marshall, Tarnya, and Rita Abdulkader. Anti-rheumatic drugs in pregnancy and lactation. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0097.

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Anti-rheumatic drugs in pregnancy and lactation are increasingly a common clinical dilemma. With the shift towards early, aggressive control of autoimmune diseases and with the advent of newer therapeutic agents, there is a need to understand the effects of these medicines in pregnancy and lactation, on fertility in both men and women, and on the process of spermatogenesis, in order to understand the risk of teratogenesis. Although there are some limited data available for the use of anti-rheumatic drugs in pregnancy and lactation, much of our knowledge is derived from animal models and from limited clinical experience in human pregnancy. The balance of therapeutic benefits and risks of harm to mother and fetus should always be carefully considered: it may vary between individuals and should be assessed on a case by case basis. Because of these issues, pregnancy should always be discussed and planned in advance, in part to reduce disease activity prior to conception but also to minimize risk to the fetus. In this chapter we use the available evidence to discuss medicines which are commonly used in the treatment of rheumatological autoimmune diseases, and cover disease-modifying anti-rheumatic drugs (DMARDS) and biological agents.
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36

E, Rowe Hilary, ed. Medications & mothers' milk 2017: A manual of lactational pharmacology. Springer Publishing Company, 2017.

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37

Buhimschi, Catalin, and Carl P. Weiner. Drugs for Pregnant and Lactating Women - CD-ROM PDA Software. Churchill Livingstone, 2003.

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38

Briggs, Gerald G., R. K. Freeman, and S. J. Yaffe. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins,US, 1999.

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39

Christof, Schaefer, ed. Drugs during pregnancy and lactation: Handbook of prescription drugs and comparative risk assessment : with updated information on recreational drugs ... Amsterdam: Elsevier, 2001.

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40

Ng, Bernardo, and Mauricio Tohen. Evidence-based treatment of mania. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0004.

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Bipolar mania can be one of the most challenging psychiatric illnesses to treat, as it requires the clinician to make rapid and accurate decisions; have a reliable way of evaluating progress and treatment response; and possess keen psychotherapeutic skills. Therefore, the importance of staying updated on the clinical evidence of the various treatment options, which serves as the basis to individualize treatment on the day-to-day progress or deterioration of the manic patient. This chapter presents a review available on the evidence of different psychopharmacological agents including typical antipsychotics, lithium, antiepileptic drugs and atypical antipsychotics, and FDA-approved dosages. This review also includes these agents’ effects on fertility and recommendations about their use during pregnancy and lactation. Bipolar disorder continues to be a complex psychiatric condition, yet the progress in treatment options for the manic phase has evolved such that we have more options than ever before.
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