Relevant bibliographies by topics / Lactose synthesis in pigs

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Lactose synthesis in pigs'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Lactose synthesis in pigs"

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Frank, Jason W., Jeffery Escobar, Agus Suryawan, et al. "Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs." American Journal of Physiology-Endocrinology and Metabolism 290, no. 2 (2006): E225—E233. http://dx.doi.org/10.1152/ajpendo.00351.2005.

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Protein synthesis and eukaryotic initiation factor (eIF) activation are increased in muscle and liver of pigs parenterally infused with amino acids and insulin. To examine the effects of enteral protein and carbohydrate on protein synthesis, pigs ( n = 42, 1.7 kg body wt) were fed isocaloric milk diets containing three levels of protein (5, 15, and 25 g·kg body wt−1·day−1) and two levels of lactose (low = 11 and high = 23 g·kg body wt−1·day−1) from 1 to 6 days of age. On day 7, pigs were gavage fed after 4-h food deprivation, and tissue protein synthesis rates and biomarkers of mRNA translatio
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Burrin, Douglas G., Timothy J. Wester, Teresa A. Davis, Marta L. Fiorotto, and Xiaoyan Chang. "Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs." American Journal of Physiology-Endocrinology and Metabolism 276, no. 2 (1999): E269—E277. http://dx.doi.org/10.1152/ajpendo.1999.276.2.e269.

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Our objective was to determine how dexamethasone (Dex) affects gastrointestinal protein metabolism and growth in neonatal pigs. Two-day-old pigs were given daily subcutaneous injections of either Dex (1 mg/kg body wt, n = 7) or saline (control, n = 6) for 7 days. In vivo protein synthesis was measured after 7 days with a bolus of [3H]phenylalanine. Tissue protein contents were measured in an initial control group of 2-day-old pigs and in control and Dex pigs after 7 days to estimate protein accretion and degradation. In control pigs, the protein accretion in the ileum was nearly sixfold greate
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Dudley, Mary A., Linda Wykes, Alden W. Dudley, et al. "Lactase Phlorizin Hydrolase Synthesis Is Decreased In Protein-Malnourished Pigs." Journal of Nutrition 127, no. 5 (1997): 687–93. http://dx.doi.org/10.1093/jn/127.5.687.

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Farmer, C., N. L. Trottier, and J. Y. Dourmad. "Review: Current knowledge on mammary blood flow, mammary uptake of energetic precursors and their effects on sow milk yield." Canadian Journal of Animal Science 88, no. 2 (2008): 195–204. http://dx.doi.org/10.4141/cjas07074.

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Dietary availability of nutrients to the mammary gland is a major limiting factor for sow milking potential. Nutrient availability to the udder is estimated by measuring mammary arteriovenous differences, which are affected by blood flow as well as circulating concentrations of nutrients. Mammary blood flow can be measured either directly or indirectly. Even though it is influenced by numerous factors, such as time since feeding, postural behavior, vasoactive substances, ambient temperature and litter size, authors report that the amount of plasma required to produce 1 kg of milk for a litter
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Dudley, M. A., F. Jahoor, D. G. Burrin, and P. J. Reeds. "Brush-border disaccharidase synthesis in infant pigs measured in vivo with [2H3]leucine." American Journal of Physiology-Gastrointestinal and Liver Physiology 267, no. 6 (1994): G1128—G1134. http://dx.doi.org/10.1152/ajpgi.1994.267.6.g1128.

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Conscious unrestrained piglets were fasted overnight and infused intravenously with [2H3]leucine for 6 h. Sucrase isomaltase and lactase phlorizin hydrolase were immunoprecipitated from jejunal mucosal membranes, and the immunoprecipitates were electrophoresed on polyacrylamide gels. Bands corresponding to the pro and mature isoforms of both enzymes were acid hydrolyzed. [2H3]leucine isotopic enrichment was measured by gas chromatography-mass spectrometry using negative chemical ionization. Plasma leucine reached isotopic steady state within 90 min. The isotopic enrichment of mucosal leucine w
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Dudley, Mary A., Patricia A. Schoknecht, Alden W. Dudley, et al. "Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient diet." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 4 (2001): G621—G628. http://dx.doi.org/10.1152/ajpgi.2001.280.4.g621.

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The in vivo effects of protein malnutrition and protein rehabilitation on lactase phlorizin hydrolase (LPH) synthesis were examined. Five-day-old pigs were fed isocaloric diets containing 10% (deficient, n = 12) or 24% (sufficient, n = 12) protein. After 4 wk, one-half of the animals in each dietary group were infused intravenously with [13C1]leucine for 6 h, and the jejunum was analyzed for enzyme activity, mRNA abundance, and LPH polypeptide isotopic enrichment. The remaining animals were fed the protein-sufficient diet for 1 wk, and the jejunum was analyzed. Jejunal mass and lactase enzyme
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DUDLEY, Mary A., Douglas G. BURRIN, Andrea QUARONI, et al. "Lactase phlorhizin hydrolase turnover in vivo in water-fed and colostrum-fed newborn pigs." Biochemical Journal 320, no. 3 (1996): 735–43. http://dx.doi.org/10.1042/bj3200735.

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We have estimated the synthesis rates in vivo of precursor and brush-border (BB) polypeptides of lactase phlorhizin hydrolase (LPH) in newborn pigs fed with water or colostrum for 24 h post partum. At the end of the feeding period, piglets were anaesthetized and infused intravenously for 3 h with l-[4-3H]-phenylalanine. Blood and jejunal samples were collected at timed intervals. The precursor and BB forms of LPH were isolated from jejunal mucosa by immunoprecipitation followed by SDS/PAGE, and their specific radioactivity in Phe determined. The kinetics of precursor and BB LPH labelling were
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Lepine, Allan J., Malcolm Watford, R. Dean BOYD, Deborah A. Ross, and Dana M. Whitehead. "Relationship between hepatic fatty acid oxidation and gluconeogenesis in the fasting neonatal pig." British Journal of Nutrition 70, no. 1 (1993): 81–91. http://dx.doi.org/10.1079/bjn19930106.

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Hepatocytes were isolated from sixteen fasting neonatal pigs and used in two experiments: (1) to determine the effect of various factors on the ability for hepatic oxidation of fatty acids and (2) to clarify the relationship between fatty acid oxidation and glucose synthesis. In Expt 1, newborn pigs were either fasted from birth for 24 h or allowed to suck ad lib. for 3 d followed by a 24 h fast. In the presence of pyruvate, oxidation of octanoate (2 mM) was about 30-fold greater than oleate (1 mM) regardless of age, but glucose synthesis was not enhanced beyond that observed for pyruvate alon
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SARKAR, N. K., J. K. G. KRAMER, J. I. ELLIOT, and M. S. WOLYNETZ. "INFLUENCE OF DIETARY FAT LEVEL ON GROWTH AND BODY COMPOSITION OF THE NEONATAL PIG." Canadian Journal of Animal Science 65, no. 1 (1985): 175–84. http://dx.doi.org/10.4141/cjas85-018.

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Four Yorkshire piglets, from each of 18 litters, were randomly allotted within litters, to four treatment groups 12 h after birth. Group 1 (Control) continued to be suckled by sows; the remaining piglets were reared artificially on a semi-synthetic liquid diet containing either 25% soybean oil (SBO) (group 2) or 3% SBO plus 22% lactose (groups 3 and 4). At 7, 14 and 21 days of age, 24 pigs from six litters were killed. Piglets on the 25% SBO diet grew faster (P < 0.05) than those on the 3% SBO diet while the growth rate of the suckled piglets tended to be between the growth rates of those o
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Dillon, E. Lichar, Darrell A. Knabe, and Guoyao Wu. "Lactate inhibits citrulline and arginine synthesis from proline in pig enterocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 5 (1999): G1079—G1086. http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1079.

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Hypocitrullinemia and hypoargininemia but hyperprolinemia are associated with elevated plasma concentration of lactate in infants. Because the small intestine may be a major organ for initiating proline catabolism via proline oxidase in the body and is the major source of circulating citrulline and arginine in neonates, we hypothesized that lactate is an inhibitor of intestinal synthesis of citrulline and arginine from proline. To test this hypothesis, jejunum was obtained from 14-day-old suckling pigs for preparation of enterocyte mitochondria and metabolic studies. Mitochondria were used for
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Dissertations / Theses on the topic "Lactose synthesis in pigs"

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Dodd, S. C. "The hormonal control of #alpha#-lactalbumin and #beta#-lactoglobulin in pig mammary gland." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234448.

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Huang, Yongshun. "Synthesis of Anticoagulant Glycopolymers and Lactose-Containing Hydrogels." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468337467.

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Gong, Ruoying. "Synthesis towards O-linked AFGP analogues with lactose as its carbohydrate component." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28309.

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Antifreeze glycoproteins (AFGPs) are biological antifreezes which are found in the blood serum of arctic fish to help them living in the subzero temperature environments. AFGPs have a common structure composed with a carbohydrate and a peptide moiety by alpha O-linkage and can inhibit ice recrystallization which is useful in medical and commercial applications. The alpha O-linkage is very sensitive to acidic, basic and enzymatic conditions, therefore design and synthesizing AFGP analogues are more attractive. Thermal hysteresis (TH) and IRI activities of AFGPs have no relationship with one ano
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Fyrner, Timmy, Thomas Ederth, Daniel Aili, Bo Liedberg, and Peter Konradsson. "Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces." Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92697.

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The ability to produce monomolecular coatings with well-defined structural and functional properties is of key importance in biosensing, drug delivery, and many recently developed applications of nanotechnology. Organic chemistry has proven to be a powerful tool to achieve this in many research areas. Herein, we present the synthesis of three oligo(lactosides) glycosylated in a (1 → 3) manner, and which are further functionalized with amide-linked short alkanethiol spacers. The oligosaccharides (di-, tetra-, and hexasaccharide) originate from the inexpensive and readily available lactose disac
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Garg, Nidhi. "Synthesis and Characterization of Lactose-Amines with Respect to Oil-in-Water Emulsion Stability." DigitalCommons@USU, 2008. https://digitalcommons.usu.edu/etd/225.

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Fatty amines (hexadecyl-amine) can be esterified to lactose via Schiff-base formation at temperatures of 60° C. Extending the time of the reaction results in a darker colored product due to the Maillard reaction. Due to the amphiphilic properties of the lactose-amines, the emulsion stabilization characteristics were investigated. In this study, synthesis of lactose-amines was done at four different heating and cooling cycles from 4 to 24 hours. Lactose-amines processed for 24 hours and 12 hours of constant heating and cooling cycles are named as 24H and 12H, respectively. Lactose-amines 4H
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Zhu, Haibo. "Muscle Growth and Development in Intrauterine Growth Restricted Pigs." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/72883.

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Intrauterine growth restriction causes impaired growth and development of mammalian fetus, and leads to long-term negative effect on postnatal growth. Among domestic animals, pigs exhibit the most severe naturally occurring IUGR and reduced postnatal muscle growth. The objectives of this research project were to: 1) determine muscle stem cell characteristics in IUGR pigs; 2) determine how intrauterine growth restriction alters protein deposition in skeletal muscle; 3) investigate whether branched-chain amino acids (BCAA) are able to enhance protein synthesis in intrauterine growth restricted
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Adams, Vanessa Lynn. "Adipogenesis in post-weanling pigs fed conjugated linoleic acid." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/1091.

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The effects of conjugated linoleic acid (CLA) on lipogenesis and preadipocyte proliferation in young pigs were evaluated in two separate experiments. The first compared dietary effects of linoleic acid, beef tallow, and CLA on composition, lipogenesis, and DNA synthesis. Eighteen pigs weaned at 17 d of age were allotted randomly to corn-based diets supplemented with 1.5% corn oil, 1.5% tallow, or 1.5% CLA. The second experiment evaluated the effects of CLA included with diets high in polyunsaturated fat or beef tallow. Twenty-four pigs weaned at 17 d of age were allotted randomly to one of
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Lisboa, Cristiane Reinaldo. "Síntese enzimática de galactooligossacarídeos a partir de lactose e soro de leite." reponame:Repositório Institucional da FURG, 2008. http://repositorio.furg.br/handle/1/2917.

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Dissertação(mestrado) - Universidade Federal do Rio Grande, Programa de Pós-Graduação em Engenharia e Ciência de Alimentos, Escola de Química e Alimentos, 2008.<br>Submitted by Caroline Silva (krol_bilhar@hotmail.com) on 2012-09-24T17:54:51Z No. of bitstreams: 1 dissertao de mestrado cristiane.pdf: 830083 bytes, checksum: 8a0fe102af2eaf27474ab995424a5309 (MD5)<br>Approved for entry into archive by Bruna Vieira(bruninha_vieira@ibest.com.br) on 2012-12-01T16:25:51Z (GMT) No. of bitstreams: 1 dissertao de mestrado cristiane.pdf: 830083 bytes, checksum: 8a0fe102af2eaf27474ab995424a5309 (MD5)<br>Ma
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Leite, Silvana Cavalcante Bastos. "Research on weaned pig diets based on sorghum-soybean meal, with isolated casein + lactose." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6044.

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FundaÃÃo de Amparo à Pesquisa do Estado do CearÃ<br>O ensaio foi realizado no Setor de Suinocultura do Centro de CiÃncias AgrÃrias do Departamento de Zootecnia da Universidade Federal do CearÃ, com o objetivo de avaliar o desempenho zootÃcnico, os indicadores do metabolismo do nitrogÃnio, o bem-estar animal e o custo de produÃÃo de leitÃes no prÃodo de creche, submetidos a dietas à base de sorgo-soja enriquecidas com caseÃna + lactose isoladas. O experimento teve a duraÃÃo de 42 dias, sendo dividido em duas fases experimentais, a saber: fase 1(21-42 dias) e fase 2 (42 a 63 dias). Foram utiliza
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Coussons, Peter John. "An investigation of the specificity of guinea pig liver transglutaminase towards protein substrates." Thesis, University of Stirling, 1991. http://hdl.handle.net/1893/21845.

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The specificity of guinea pig liver transglutamlnase was Investigated by the determination of modification sites within polypeptides and proteins of known sequence and (In some cases) folded structure. It was shown that some globular proteins have substrate properties for transglutamlnase In conformations which resemble their native states. Novel substrate sites for transglutamlnase were determined within the following proteins: 1) bovine B-Iactoglobulln. 2) the Hls3~ Gln388 mutant form of yeast phosphoglycerate kinase. 3) bovine B-caseln. 4) porcine pepsin. Despite the high exposure of many g
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Books on the topic "Lactose synthesis in pigs"

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Skiba, Grzegorz. Fizjologiczne, żywieniowe i genetyczne uwarunkowania właściwości kości rosnących świń. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_gs_2020.

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Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones a
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Guideline for Preventive Chemotherapy for the Control of Taenia solium Taeniasis. Pan American Health Organization, 2021. http://dx.doi.org/10.37774/9789275123720.

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The larval stage of the parasite Taenia solium can encyst in the central nervous system causing neurocysticercosis, which is the main cause of acquired epilepsy in the countries in which the parasite is endemic. Endemic areas are those with the presence (or likely presence) of the full life cycle of Taenia solium. The parasite is most prevalent in poor and vulnerable communities in which pigs roam free, open defecation is practiced, basic sanitation is deficient, and health education is absent or limited. Several tools are available for the control of Taenia solium. Preventive chemotherapy for
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Book chapters on the topic "Lactose synthesis in pigs"

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Plou, Francisco J., Julio Polaina, Julia Sanz-Aparicio, and María Fernández-Lobato. "β-Galactosidases for Lactose Hydrolysis and Galactooligosaccharide Synthesis." In Microbial Enzyme Technology in Food Applications. CRC Press, 2017. http://dx.doi.org/10.1201/9781315368405-9.

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Yin, Fugui, Yulong Yin, and Yongqing Hou. "Synthesis and Degradation of Proteins in Pigs." In Nutritional and Physiological Functions of Amino Acids in Pigs. Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1328-8_8.

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Xiao, Dingfu, Fugui Yin, Yulong Yin, et al. "Measurement of Synthesis and Degradation of Proteins." In Nutritional and Physiological Functions of Amino Acids in Pigs. Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1328-8_18.

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Suyama, Kyozo, and Susumu Adachi. "Enzymatic synthesis of new trisaccharide, isoraffinose, from a mixture of lactose and sucrose." In MILK the vital force. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-3733-8_182.

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Maxin, G., D. R. Ouellet, and H. Lapierre. "Contribution of amino acids to glucose and lactose synthesis in lactating dairy cows." In Energy and protein metabolism and nutrition in sustainable animal production. Wageningen Academic Publishers, 2013. http://dx.doi.org/10.3920/978-90-8686-781-3_165.

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Boutry, C., S. W. El-Kadi, A. Suryawan, et al. "Supplementation with a leucine pulse during continuous feeding stimulates protein synthesis and suppresses protein degradation pathways in skeletal muscle of neonatal pigs." In Energy and protein metabolism and nutrition in sustainable animal production. Wageningen Academic Publishers, 2013. http://dx.doi.org/10.3920/978-90-8686-781-3_151.

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Mardones, Lorena, and Marcelo Villagrán. "Lactose Synthesis." In Lactose and Lactose Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.91399.

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This chapter is related to lactose synthesis, its chemistry, regulation, and differences between species, especially in cattle. Lactose synthesis takes place in the Golgi apparatus of mammary epithelial cells (MEC) by the lactose synthase (LS) enzyme complex from two precursors, glucose and UDP-galactose. The enzyme complex is formed by galactosyltransferase, and it is associated with α-lactalbumin. Importantly, the lactose secreted determines the volume of milk produced, due to its osmotic properties. Milk contains 5% lactose and 80% water, percentages that remain constant during lactation in the different mammalian species. The low variation in milk lactose content indicates that lactose synthesis remains constant throughout the period of lactation and that is highly conserved in all mammals. Lactose synthesis is initiated during the first third of the pregnancy, increasing after birth and placenta removal. Different glucose transporters have been involved in mammary glucose uptake, mainly facilitative glucose transporters GLUT1, GLUT8, and GLUT12 and sodium-glucose transporter SGLT1, with more or less participation depending on mammal species.
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I. Martinez-Monteagudo, Sergio, Kaavya Rathnakumar, Maryam Enteshari, Collette Nyuydze, Juan C. Osorio-Arias, and Hiran Ranaweera. "Hundred Years of Lactitol: From Hydrogenation to Food Ingredient." In Lactose and Lactose Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93365.

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The first report on the synthesis of lactitol dates back to the early 1920s. Nearly 100 years have passed since then, and the applications of lactitol have exceeded its original purpose. Currently, lactitol is used in bakery, confectionery, chocolate, desserts, chewing gum, cryoprotectant, delivery agent, and stabilizer in biosensors. Lactitol is the main reaction product derived from the hydrogenation of lactose. This chapter is aimed at providing a succinct overview of the historical development of lactitol, a summary of its synthesis, and an overview of its properties and applications.
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Manuel Pais-Chanfrau, José, Jimmy Núñez-Pérez, Rosario del Carmen Espin-Valladares, Marcos Vinicio Lara-Fiallos, and Luis Enrique Trujillo-Toledo. "Bioconversion of Lactose from Cheese Whey to Organic Acids." In Lactose and Lactose Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92766.

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Organic acids constitute a group of organic compounds that find multiple applications in the food, cosmetic, pharmaceutical, and chemical industries. For this reason, the market for these products is continuously growing. Traditionally, most organic acids have been produced by chemical synthesis from oil derivatives. However, the irreversible depletion of oil has led us to pay attention to other primary sources as possible raw materials to produce organic acids. The microbial production of organic acids from lactose could be a valid, economical, and sustainable alternative to guarantee the sustained demand for organic acids. Considering that lactose is a by-product of the dairy industry, this review describes different procedures to obtain organic acids from lactose by using microbial bioprocesses.
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María Guevara-Alvarado, Hada, Néstor Gutiérrez-Méndez, Esther Carrillo-Pérez, Einar Vargas-Bello-Pérez, and José Carlos Rodríguez-Figueroa. "Value-Added Compounds with Health Benefits Produced from Cheese Whey Lactose." In Lactose and Lactose Derivatives. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94197.

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Cheese whey (CW) is the yellow-green liquid main by-product from cheese manufacturing. Historically, it has been recognized as a major environmental pollutant. Nowadays, it represents a source of high-quality nutrients, such as lactose. Enzymatic bioprocesses, chemical synthetic reactions and microbial bioprocesses use lactose as substrate to obtain relevant derivatives such as lactitol, lactulose, lactosucrose, sialyllactose, kefiran and galacto-oligosaccharides. These lactose derivatives stimulate the growth of indigenous bifidobacteria and lactobacilli improving the intestinal motility, enhancing immunity and promoting the synthesis of vitamins. Also, they have versatile applications in pharmaceutical, biotechnological and food industries. Therefore, this book chapter shows the state of the art focusing on recent uses of CW lactose to produce value-added functional compounds and discusses new insights associated with their human health-promoting effects and well-being.
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Conference papers on the topic "Lactose synthesis in pigs"

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Lucarini, Simone. "Lactose-based Fatty Acid Monoesters: Synthesis, antimicrobial activity and permeability enhancement studies." In 5th International Electronic Conference on Medicinal Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06340.

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Backliwal, G., S. Kumar, and J. Gomes. "Comparison of lovastatin synthesis using glucose and lactose by metabolic flux analysis." In MICROBES IN APPLIED RESEARCH - Current Advances and Challenges. WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814405041_0077.

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Cavalcante Fai Buarque de Gusmão, Ana Elizabeth, Haroldo Yukio Kawaguti, Isabela Thomazelli, and Glaucia Maria Pastore. "Comparison of galactooligosaccharides synthesis during lactose hydrolysis by immobilized Aspergillus oryzae beta-galactosidase systems." In Simpósio Nacional de Bioprocessos e Simpósio de Hidrólise Enzimática de Biomassa. Galoá, 2015. http://dx.doi.org/10.17648/sinaferm-2015-33686.

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Lloyd, J. V., S. E. Rodgers, D. M. Siebert, F. Bochner, G. H. McIntosh, and M. James. "PRESYSTEMIC DEACETYLATION OF LOW DOSES OF ENTERIC COATED ASPIRIN IN A PIG MODEL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643856.

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The antithrombotic effect of aspirin might be enhanced if platelet cyclooxygenase could be inhibited in the portal ciculation while sparing cyclooxygenase in the systemic vascular endothelium. This might be achieved by modifying the dose and formulation to maximise presystemic aspirin clearance by the liver. To test this hypothesis low dose enteric coated aspirin (Astrix, 50mg single dose, lOOmg single dose and lOOmg daily for 1 week) was orally administered to pigs with permanent indwelling arterial and portal vein catheters. Plasma aspirin concentrations were measured by high performance liq
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Schick, B. P., C. J. Walsh, and T. Jenkins-West. "CHANGES IN PROTEOGLYCAN AND SULFATED PROTEIN SYNTHESIS DURING MEGAKARYOCYTE MATURATION IN VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644620.

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We investigated changes in sulfated proteoglycan (PG) and sulfated protein synthesis during megakaryocyte (MK) maturation in vivo by characterizing the (35S)-labeled molecules in MKs and platelets (PLTs) obtained daily from 3 hr to 5 days after injection of guinea pigs with (35S)sulfate. Radioactivity in macromolecules was maximal in MKs 3 hr and in PLTs 3 days after the injection. The cells were solubilized in 8M urea/50mM Tris/0.2% Triton X-100/0.1M NaCl, and PGs and sulfoproteins were separated by DEAE-Sephacel chromatography. PGs (65% of cell 35s) were eluted as two fractions, one (PG-1, 8
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Hart, James D., Nasir Zulfiqar, David H. Moore, and Greg R. Swank. "“Digital Pigging” as a Basis for Improved Pipeline Structural Integrity Evaluations." In 2006 International Pipeline Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/ipc2006-10349.

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This paper describes the application of “digital pigging” procedures for converting field measurements of pipeline geometry (e.g., top of pipe survey profiles), results from geometry pig surveys, or analytically generated pipeline centerline profiles into corresponding profiles of pipeline curvature and bending strain. Application of digital pigging procedures to pipeline elevation and/or inclination profiles developed from accelerometer based geometry pigs provides a basis for performing the additional calculations required to develop bending strain profiles which may not be a part of the geo
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Lewis, R. M., P. B. Jahrling, B. P. Griffin, and T. M. Cosgriff. "THE EFFECTS OF HEMORRHAGIC FEVER VIRUS INFECTION OF ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643352.

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Pichindé viral infection of strain 13 guinea pigs is a model for Lassa fever virus in humans. Infected animals show impaired platelet function and altered coagulation parameters. Human endothelial cells and the human endothe1ia1-1 ike cell line, EA926, were infected with Pichinde virus. Following infection, cultures were monitored by phase contract microscopy for cytopathic effect (CPE). Assays of supernatant were used to document viral growth and to measure those endothelial-produced components that might affect hemostasis. In addition, the cells were stimulated with phorbol ester (PMA), whic
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