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Journal articles on the topic 'Lactose'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Xu, Yunli, Guowei Shu, Chunji Dai, et al. "Screening of lactases suitable for the preparation of low-lactose prebiotic liquid milk and optimisation of their combination." Acta Universitatis Cibiniensis. Series E: Food Technology 25, no. 2 (2021): 275–84. http://dx.doi.org/10.2478/aucft-2021-0025.

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Abstract Lactose intolerance is an important factor restricting the consumption of dairy products. Lactase is used to hydrolyze lactose in milk while generating galactooligosaccharides (GOS), thereby reducing the incidence of lactose intolerance. We used cow milk as raw materials, and selected enzyme preparations with high lactose hydrolysis rate and strong GOS generation ability from 14 commercially available lactase enzymes. The lactose hydrolysis rate is 5.85%-81.38%, and the GOS content is 0.03 g/L- 13.10 g/L. The mixing experiment design determined the two lactase enzymes (E10 and E11) ra

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Zhao, Di, Thao T. Le, Lotte Bach Larsen та ін. "Interplay between Residual Protease Activity in Commercial Lactases and the Subsequent Digestibility of β-Casein in a Model System". Molecules 24, № 16 (2019): 2876. http://dx.doi.org/10.3390/molecules24162876.

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One of the conventional ways to produce lactose-hydrolyzed (LH) milk is via the addition of commercial lactases into heat-treated milk in which lactose is hydrolyzed throughout storage. This post-hydrolysis method can induce proteolysis in milk proteins due to protease impurities remaining in commercial lactase preparations. In this work, the interplay between lactose hydrolysis, proteolysis, and glycation was studied in a model system of purified β-casein (β-CN), lactose, and lactases using peptidomic methods. With a lactase presence, the proteolysis of β-CN was found to be increased during s

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3

Szilagyi, Andrew. "Adult Lactose Digestion Status and Effects on Disease." Canadian Journal of Gastroenterology and Hepatology 29, no. 3 (2015): 149–56. http://dx.doi.org/10.1155/2015/904686.

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BACKGROUND: Adult assimilation of lactose divides humans into dominant lactase-persistent and recessive nonpersistent phenotypes.OBJECTIVES: To review three medical parameters of lactose digestion, namely: the changing concept of lactose intolerance; the possible impact on diseases of microbial adaptation in lactase-nonpersistent populations; and the possibility that the evolution of lactase has influenced some disease pattern distributions.METHODS: A PubMed, Google Scholar and manual review of articles were used to provide a narrative review of the topic.RESULTS: The concept of lactose intole

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Forsgård, Richard A. "Lactose digestion in humans: intestinal lactase appears to be constitutive whereas the colonic microbiome is adaptable." American Journal of Clinical Nutrition 110, no. 2 (2019): 273–79. http://dx.doi.org/10.1093/ajcn/nqz104.

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ABSTRACTGlobally, ∼70% of adults are deficient in intestinal lactase, the enzyme required for the digestion of lactose. In these individuals, the consumption of lactose-containing milk and dairy products can lead to the development of various gastrointestinal (GI) symptoms. The primary solution to lactose intolerance is withdrawing lactose from the diet either by eliminating dairy products altogether or substituting lactose-free alternatives. However, studies have shown that certain individuals erroneously attribute their GI symptoms to lactose and thus prefer to consume lactose-free products.

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Angima, Gloria, Yunyao Qu, Si Hong Park, and David C. Dallas. "Prebiotic Strategies to Manage Lactose Intolerance Symptoms." Nutrients 16, no. 7 (2024): 1002. http://dx.doi.org/10.3390/nu16071002.

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Lactose intolerance, which affects about 65–75% of the world’s population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. Symptoms of lactose intolerance include abdominal pain, bloating and diarrhea. Genetic variations, namely lactase persistence, allow some individuals to metabolize lactose effectively post-weaning, a trait thought to be an evolutionary adaptation to dairy consumption. Although lactase non-persistence cannot be altered by diet, prebiotic strategies, including the consumption of

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Montgomery, Robert K., Stephen D. Krasinski, Joel N. Hirschhorn, and Richard J. Grand. "Lactose and Lactase—Who Is Lactose Intolerant and Why?" Journal of Pediatric Gastroenterology and Nutrition 45, Suppl 2 (2007): S131—S137. http://dx.doi.org/10.1097/mpg.0b013e31812e68f6.

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Rachwał, Krystian, Karol Wielgus, Piotr Bator, et al. "Lactase Deficiency and Lactose Intolerance: Current Understanding and Future Directions." Journal of Education, Health and Sport 69 (May 17, 2024): 49393. http://dx.doi.org/10.12775/jehs.2024.69.49393.

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Introduction and purpose: Lactose, the primary carbohydrate in milk, requires the enzyme lactase for digestion. Deficiency in lactase activity leads to lactose intolerance, causing gastrointestinal symptoms. Understanding the genetic and environmental factors influencing lactase expression and activity is crucial. Moreover, accurate diagnostic methods and effective treatments are needed to manage lactose intolerance. This review aims to explore the current knowledge on lactase deficiency, lactose intolerance, diagnostic methods, and treatment options. State of knowledge: Lactase deficiency enc

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8

Shao, Xiyue. "Brief classification and latest therapy for lactose intolerance." Theoretical and Natural Science 6, no. 1 (2023): 299–305. http://dx.doi.org/10.54254/2753-8818/6/20230257.

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Lactose intolerance is a digestive problem with a high incidence worldwide. The disease occurs mainly due to a lack or deficiency of lactase in the body, which prevents effective digestion of lactose. Congenital lactose intolerance is caused by a genetic defect that prevents the body from producing enough lactase, and its incidence is relatively low. Secondary lactose intolerance is caused by other gastrointestinal disorders, such as celiac disease, and is relatively common. Functional lactose intolerance is the most common form of lactose intolerance, in which lactase activity is reduced or l

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Szilagyi, Andrew, Albert Cohen, Christina Vinokuroff, Darakhshan Ahman, Usha Nathwani, and Samara Yesovitch. "Deadaption and Readaptation with Lactose, But No Cross-Adaptation to Lactulose: A Case of Occult Colonic Bacterial Adaptation." Canadian Journal of Gastroenterology 18, no. 11 (2004): 677–80. http://dx.doi.org/10.1155/2004/763529.

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The standard 3 h breath hydrogen (3hBH2) test distinguishes lactose maldigesters from lactose digesters. However, multiple factors impact on BH2and care is needed to exclude a priori variables. When these factors are controlled, a negative BH2test implies lactase persistent status or lactase nonpersistent status with colonic adaptation. A case of a Sicilian man who tested negative (lactase persistent status confirmed) on an initial 50 g lactose challenge is described. It was observed that he consumed 28.1 g lactose/day before testing. He subsequently underwent five additional challenge tests i

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10

Marushko, Yurii, and Svitlana Yesypova. "The Problem of Lactase Deficiency: Diagnosis and Treatment Approaches in Children." Family medicine. European practices, no. 3 (September 29, 2023): 29–34. http://dx.doi.org/10.30841/2786-720x.3.2023.289337.

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The article is devoted to one of the most urgent problems of pediatrics – the malabsorption syndrome caused by lactose intolerance in children of different age periods. Lactose intolerance refers to the inability of the intestinal enzyme systems to break down lactose, which manifests itself clinically. In fact, lactose intolerance is a clinical manifestation of lactase deficiency (LD), that is, a decrease in the activity of lactase in the intestine, which can be congenital or acquired. The purpose of the study is to analyze literature data on the factors of occurrence and clinical manifestatio

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Marushko, Yurii, and Svitlana Yesypova. "The Problem of Lactase Deficiency: Diagnosis and Treatment Approaches in Children." Family Medicine. European Practices, no. 3 (September 29, 2023): 29–34. https://doi.org/10.30841/2786-720X.3.2023.289337.

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The article is devoted to one of the most urgent problems of pediatrics – the malabsorption syndrome caused by lactose intolerance in children of different age periods. Lactose intolerance refers to the inability of the intestinal enzyme systems to break down lactose, which manifests itself clinically. In fact, lactose intolerance is a clinical manifestation of lactase deficiency (LD), that is, a decrease in the activity of lactase in the intestine, which can be congenital or acquired.The purpose of the study is to analyze literature data on the factors of occurrence and clinical manifestation

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12

Fassio, Filippo, Maria Facioni, and Fabio Guagnini. "Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives." Nutrients 10, no. 11 (2018): 1599. http://dx.doi.org/10.3390/nu10111599.

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Milk is a fundamental component of the diet of every mammal; nevertheless, not every individual can tolerate this kind of food, especially in adulthood. However, lactose intolerance has only been recognized in the last 50 years, and currently, lactose intolerance is defined as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhoea that occur after lactose consumption. Lactose is currently a common disaccharide in human nutrition, both in breastfed infants and in adults, but its digestion requires a specialized enzyme called lactase. The genetically programme

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13

Renner, E. "Dietary approaches to alleviation of lactose maldigestion / Efectos de la dieta sobre la digestión de la lactosa." Food Science and Technology International 3, no. 2 (1997): 71–79. http://dx.doi.org/10.1177/108201329700300201.

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Because dairy products are a significant source of essential nutrients, elimination of all dairy foods in the diet would be nutritionally unwise and is usually not necessary in the case of lactose maldigestion. About 250 ml milk/d can generally be taken without adverse effects. If milk is taken in combination with solid foods, lactose malabsorption may be reduced by about 50%, probably due to a slower rate of colonic fermentation which may lower gastrointestinal symptoms in lactose malabsorbers. It is well established that, in lactase-deficient subjects, yoghurt is better tolerated than milk.

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14

Saliha Khalid, Yumna Amjad, Laraib Zafar, et al. "Systematic review: Diagnosis, treatment and management strategies of lactose intolerance." Open Access Research Journal of Biology and Pharmacy 12, no. 1 (2024): 001–13. http://dx.doi.org/10.53022/oarjbp.2024.12.1.0032.

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Lactose, a disaccharide composed of glucose and galactose, plays a pivotal role in the nutritional physiology of mammals, particularly during infancy. This thesis explores the comprehensive biochemical pathways involved in lactose metabolism and synthesis, highlighting its significance in both health and disease. The study begins by examining lactose synthesis within the mammary glands, where lactose synthase catalyzes the formation of lactose from glucose and UDP-galactose during lactation. The metabolic breakdown of lactose in the small intestine, facilitated by the enzyme lactase, is essent

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15

Cooper, B. T. "Lactase Deficiency and Lactose Malabsorption." Digestive Diseases 4, no. 2 (1986): 72–82. http://dx.doi.org/10.1159/000171139.

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16

Romero-Velarde, Enrique, Dagoberto Delgado-Franco, Mariana García-Gutiérrez, et al. "The Importance of Lactose in the Human Diet: Outcomes of a Mexican Consensus Meeting." Nutrients 11, no. 11 (2019): 2737. http://dx.doi.org/10.3390/nu11112737.

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Lactose is a unique component of breast milk, many infant formulas and dairy products, and is widely used in pharmaceutical products. In spite of that, its role in human nutrition or lactose intolerance is generally not well-understood. For that reason, a 2-day-long lactose consensus meeting with health care professionals was organized in Mexico to come to a set of statements for which consensus could be gathered. Topics ranging from lactase expression to potential health benefits of lactose were introduced by experts, and that was followed by a discussion on concept statements. Interestingly,

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17

Lee, Ja Hyun, Hah Young Yoo, Da Un Jung, et al. "Research Trend of Lactulose Production from Lactose." Korean Chemical Engineering Research 52, no. 4 (2014): 407–12. http://dx.doi.org/10.9713/kcer.2014.52.4.407.

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18

Seoane, Rafael G., Verónica Garcia-Recio, Manuel Garrosa, et al. "Human Health Effects of Lactose Consumption as a Food and Drug Ingredient." Current Pharmaceutical Design 26, no. 16 (2020): 1778–89. http://dx.doi.org/10.2174/1381612826666200212114843.

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: Lactose is a reducing sugar consisting of galactose and glucose, linked by a β (1→4) glycosidic bond, considered as an antioxidant due to its α-hydroxycarbonyl group. Lactose is widely ingested through the milk and other unfermented dairy products and is considered to be one of the primary foods. On the other hand, lactose is also considered as one of the most widely used excipients for the development of pharmaceutical formulations. In this sense, lactose has been related to numerous drug-excipient or drug-food pharmacokinetic interactions. : Intolerance, maldigestion and malabsorption of c

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Vionnet, Nathalie, Linda H. Münger, Carola Freiburghaus, et al. "Assessment of lactase activity in humans by measurement of galactitol and galactonate in serum and urine after milk intake." American Journal of Clinical Nutrition 109, no. 2 (2019): 470–77. http://dx.doi.org/10.1093/ajcn/nqy296.

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ABSTRACT Background Lactase is an enzyme that hydrolyzes lactose into glucose and galactose in the small intestine, where they are absorbed. Hypolactasia is a common condition, primarily caused by genetic programming, that leads to lactose maldigestion and, in certain cases, lactose intolerance. Galactitol and galactonate are 2 products of hepatic galactose metabolism that are candidate markers for the intake of lactose-containing foods. Objectives The primary objective of the study was to explore the changes in serum and urine metabolomes during postprandial dairy product tests through the as

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Castellano, Beatriz França, Carolina Maria Aumann Sardá, Fernanda Prehs Izar, et al. "Intolerância à lactose: diagnóstico clínico laboratorial e genético." BioSCIENCE 80, no. 2 (2022): 12. http://dx.doi.org/10.55684/80.2.12.

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Introdução: A intolerância à lactose é síndrome decorrente da má digestão do dissacarídeo lactose por deficiência da enzima lactase, gerando sintomas principalmente gastrintestinais. Ela envolve 4 causas principais: deficiência congênita de lactase; deficiência de lactase de desenvolvimento; intolerância primária à lactose; e deficiência secundária à lactase.  Objetivo: Revisão da apresentação clínica da intolerância à lactose e os principais métodos disponíveis para seu diagnóstico clínico.  Método: Revisão narrativa da base de dados PubMed, por meio das palavras-chave “lactose in

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de Carvalho Barone, Ana Clara, María Da Conceição Soares da Silva, Isabella Pereira Pimenta Oliveira, and Filipe Pereira de Araújo. "Intolerância à lactose e má absorção: manifestações clínicas, diagnóstico e tratamento." Brazilian Journal of Implantology and Health Sciences 6, no. 10 (2024): 707–20. http://dx.doi.org/10.36557/2674-8169.2024v6n10p707-720.

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Introdução: A intolerância a alimentos que contêm lactose é comum. Os sintomas de intolerância à lactose são dor abdominal, flatulência, náusea, inchaço e diarreia após a ingestão de leite ou produtos que contêm leite. Esses sintomas podem estar associados à má absorção de lactose, que resulta de baixos níveis de lactase do intestino delgado. Objetivos: discutir a intolerância à lactose e má absorção e suas manifestações clínicas, diagnóstico e tratamento. Metodologia: Revisão de literatura integrativa a partir de bases científicas de dados da Scielo, da PubMed e da BVS, no período de janeiro

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Chin, Elizabeth, Liping Huang, Yasmine Bouzid, Joanne Arsenault, Charles Stephensen, and Danielle Lemay. "Estimated Daily Lactose Consumption in Healthy U.S. Adults in Relation to Lactase Persistence Genotype (rs4988235)." Current Developments in Nutrition 4, Supplement_2 (2020): 1250. http://dx.doi.org/10.1093/cdn/nzaa058_008.

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Abstract Objectives Lactase persistence (LP), a heritable trait in which lactose can be digested throughout adulthood, is often used to predict dairy intake. However, it is currently unknown how LP relates to daily lactose consumption in healthy US adults. The objective of the study was to estimate lactose from foods reported in the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) and to compare lactose and total dairy consumption in relation to LP genotypes. Methods ASA24 dietary data were collected from healthy Caucasians and Hispanics (n = 215) genotyped for the lactase p

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Campbell, Anthony K., Jonathan P. Waud, and Stephanie B. Matthews. "The Molecular basis of Lactose Intolerance." Science Progress 88, no. 3 (2005): 157–202. http://dx.doi.org/10.3184/003685005783238408.

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A staggering 4000 million people cannot digest lactose, the sugar in milk, properly. All mammals, apart from white Northern Europeans and few tribes in Africa and Asia, lose most of their lactase, the enzyme that cleaves lactose into galactose and glucose, after weaning. Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ethnic groups and individuals within a group. The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene

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Arifin, M., Ikhwanudin, Z. K. Barokah та ін. "Utilization of β-Galactosidase to Produce Lactose-Free Cow’s Milk And Its Derivative Product". IOP Conference Series: Earth and Environmental Science 1484, № 1 (2025): 012027. https://doi.org/10.1088/1755-1315/1484/1/012027.

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Abstract Lactose-intolerant individuals often avoid milk and dairy products due to an inability to digest lactose effectively. Lactose can be enzymatically broken down into galactose and glucose by β-galactosidase (lactase), producing lactose-free milk. As a derivative, lactose-free yogurt offers a safer alternative for lactose-intolerant individuals. This study aims to evaluate the physical, chemical, microbiological, and sensory properties of lactose-free milk and its derivative product, yogurt. Milk quality data were analyzed using a completely randomized design (CRD) with three replication

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Misselwitz, Benjamin, Matthias Butter, Kristin Verbeke, and Mark R. Fox. "Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management." Gut 68, no. 11 (2019): 2080–91. http://dx.doi.org/10.1136/gutjnl-2019-318404.

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Lactose is the main source of calories in milk, an essential nutriedigestion, patients with visceral hypersensitivity nt in infancy and a key part of the diet in populations that maintain the ability to digest this disaccharide in adulthood. Lactase deficiency (LD) is the failure to express the enzyme that hydrolyses lactose into galactose and glucose in the small intestine. The genetic mechanism of lactase persistence in adult Caucasians is mediated by a single C→T nucleotide polymorphism at the LCTbo −13’910 locus on chromosome-2. Lactose malabsorption (LM) refers to any cause of failure to

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Costa, Simone Leal da, Natália Porfírio Rossi, and Rafael Resende Maldonado. "Evaluation of Lactose in Milk and Dairy Products." International Journal for Innovation Education and Research 1, no. 3 (2013): 56–59. http://dx.doi.org/10.31686/ijier.vol1.iss3.115.

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Milk is an emulsion containing fat, protein, carbohydrate, vitamins, minerals and water. Lactose is the main carbohydrate presented in milk and dairy products. This sugar is composed by one unit of glucose and one of galactose. Metabolism of lactose depends on enzyme lactase which hydrolyzes this sugar. In some cases, lactase may be absent or an insufficient quantity in human body. Deficiency in lactase production causes numerous symptoms such as diarrhea; abdominal pain and bloating that characterize lactose intolerance. The aim of this work was to evaluate concentration of lactose in milk an

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Arifin, Muhamad. "Physical, Chemical and Organoleptic Characteristics of Lactose-Free Milk-Based Ice Cream." Jurnal Teknologi Hasil Peternakan 6, no. 1 (2025): 105–15. https://doi.org/10.24198/jthp.v6i1.61822.

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Lactose-intolerant individuals avoid consuming milk and dairy products, which may lead to deficiencies in essential nutrients naturally present in milk. Lactose-free milk, characterized by its higher sweetness compared to full-cream milk, serves as an ideal base for ice cream—a widely consumed product valued for its sweetness and unique texture. This study aims to analyze the physical, chemical and organoleptic characteristics of lactose-free ice cream. Lactose-free milk was produced using 0.2% lactase enzyme. The evaluated parameters included viscosity, overrun, melting time, pH, sweetness le

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Abaturov, Alexandr Ye, Yuri M. Stepanov, and Anna A. Nikulina. "TREATMENT OF LACTASE DEFICIENCY IN CHILDREN’S OBESITY WITH GENOTYPE C/C 13910 OF LACTASE GENE." Wiadomości Lekarskie 72, no. 1 (2019): 17–21. http://dx.doi.org/10.36740/wlek201901103.

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Introduction: Excess lactose in the diet of modern man causes the development of not only lactase deficiency, but it can be a factor that contributes to obesity. The aim: To study associations between obesity and genotype C/C 13910 of lactase gene (LCT) in children, to investigate the effectiveness of treatment using drug exogenous lactase and a low-lactose diet. Materials and methods: genotyping of lactase gene by real-time polymerase chain reaction, determining the level of lactose maldigestion by hydrogen breath test (HBT), estimating the insulin resistance with the HOMA-IR index in 70 obes

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Domżał-Magrowska, Danuta, Marek K. Kowalski, and Ewa Małecka-Wojciesko. "Subjective, but not documented, lactose intolerance accompanies irritable bowel syndrome." Postępy Higieny i Medycyny Doświadczalnej 76, no. 1 (2022): 444–49. http://dx.doi.org/10.2478/ahem-2022-0027.

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Abstract Introduction Lactose intolerance, due to lactase deficiency, may overlap with the symptoms of irritable bowel syndrome (IBS) or lead to an incorrect diagnosis of IBS. Identification of lactose intolerance and lactase deficiency enables targeted treatment to be implemented. The aim of the study was to search for a frequency of a lactose intolerance symptoms in patients with IBS, depending on the results of hydrogen breath test (HBT). Materials and Methods The study involved 56 patients with IBS and 23 healthy people. Both, IBS patients and healthy controls, were asked to complete a sur

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Shubham, Shubham Arjun Lonkar, Anju Boora Khatkar, Narender Kumar Chandla, et al. "Lactose Intolerance: A Review for facts and fictions." Environment Conservation Journal 23, no. 3 (2022): 479–85. http://dx.doi.org/10.36953/ecj.7382076.

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Milk is assumed to be a complete food, due to its high nutritional status. Regular consumption of milk reduces the problems of nutrition deficiency. Milk contains sugar, mainly lactose in higher amount and lactose, with other ingredients of milk, also contributes to maintain the energy level of body. But, in some cases a problem arises due to the intake of lactose mainly owing to the deficiency of ?-galactosidase (Lactase) enzyme. Deficiency of lactase enzyme in human body, results in inefficiency of body for degrading the lactose into its smaller constituents. Un-degraded/ undigested lactose

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Gorlova, A. I., and A. M. Ilyina. "The physiological role of lactose in native and hydrolyzed milk: a review." Proceedings of the Voronezh State University of Engineering Technologies 84, no. 2 (2022): 57–61. http://dx.doi.org/10.20914/2310-1202-2022-2-57-61.

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Lactose is a disaccharide composed of glucose and galactose fragments. It is the most predominant carbohydrate found in milk. The physiological significance of lactose is primarily determined by its energetic properties. Consuming lactose helps maintain the balance of the gut microflora. In addition, lactose stimulates the absorption of calcium in children and helps to increase bone strength. However, not all people absorb lactose equally. In the body, lactose is hydrolyzed by the enzyme β-galactosidase (lactase). Lactase deficiency in the gastrointestinal tract causes lactose intolerance and

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Mukhanbetzhanov, N. A., Zh Ye Mukhanbetzhanova, S. S. Kozhakhmetov, and A. R. Kushugulova. "The role of probiotics in the modulation of intestinal microbiota in lactose intolerance." BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series 145, no. 4 (2023): 86–96. http://dx.doi.org/10.32523/2616-7034-2023-145-4-86-96.

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Lactose intolerance is one of the most common eating disorders. People affected by this disorder cannot digest large amounts of lactose due to the genetically low expression of the lactase enzyme. The human gut microbiota consists of the majority of diverse microbial communities that affect intestinal health, immunological balance and also metabolize lactose. One of the methods to combat this disorder is the use of probiotics. Probiotic microorganisms are contained in large quantities in live fermented milk products, which are used as functional food products all over the world because of thei

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Szilagyi, Andrew, and Norma Ishayek. "Lactose Intolerance, Dairy Avoidance, and Treatment Options." Nutrients 10, no. 12 (2018): 1994. http://dx.doi.org/10.3390/nu10121994.

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Lactose intolerance refers to symptoms related to the consumption of lactose-containing dairy foods, which are the most common source for this disaccharide. While four causes are described, the most common is the genetically-determined adult onset lactose maldigestion due to loss of intestinal lactase governed by control of the gene by a 14,000 kb promoter region on chromosome 2. Gastrointestinal symptoms from lactose have expanded to include systemic effects and have also been confounded by other food intolerances or functional gastrointestinal disorders. Partly because lactose maldigestion i

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Usai-Satta, Paolo, and Mariantonia Lai. "New Perspectives on Lactose Malabsorption, Celiac Disease and Related Disorders." Nutrients 15, no. 11 (2023): 2512. http://dx.doi.org/10.3390/nu15112512.

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Szilagyi, Andrew. "Redefining Lactose as a Conditional Prebiotic." Canadian Journal of Gastroenterology 18, no. 3 (2004): 163–67. http://dx.doi.org/10.1155/2004/350732.

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Lactose in dairy products is maldigested by up to 70% to 75% of the world's population and many people may therefore suffer symptoms reminiscent of irritable bowel syndrome. As a result, most research to date has concentrated on ways of improving lactose tolerance to enhance dairy as a source of nutrition. However, research on other possible benefits of lactose and its maldigestion has lagged. In view of an exponential growth in the understanding of intestinal microfloral host interactions and the expanding therapeutical potential of probiotics, a reassessment of the role of lactose as a poten

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Roslavtseva, Elena A., Ina Sokolov, Olga I. Simonova, et al. "Diagnostic possibilities of lactase deficiency in children with cystic fibrosis." Russian Pediatric Journal 24, no. 3 (2021): 157–62. http://dx.doi.org/10.46563/1560-9561-2021-24-3-157-162.

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Introduction. Children with cystic fibrosis often have gastrointestinal symptoms despite properly selected primary therapy and pancreatic substitution therapy. A possible reason is lactase deficiency. Aim is to determine the frequency of lactase deficiency in children with cystic fibrosis and the need for appropriate dietary correction of their diets. Materials and methods. In 213 children with cystic fibrosis, during esophagogastroduodenoscopy in biopsies of the small intestinal mucosa 359 rapid tests, «Lactose intolerance quick test” were performed. According to the results of an express tes

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Liburdi, Katia, and Marco Esti. "Galacto-Oligosaccharide (GOS) Synthesis during Enzymatic Lactose-Free Milk Production: State of the Art and Emerging Opportunities." Beverages 8, no. 2 (2022): 21. http://dx.doi.org/10.3390/beverages8020021.

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Much attention has recently been paid to β-Galactosidases (β-D-galactoside galactohidrolase; EC 3.2.1.23), commonly known as lactases, due to the lactose intolerance of the human population and the importance of dairy products in the human diet. This enzyme, produced by microorganisms, is being used in the dairy industry for hydrolyzing the lactose found in milk to produce lactose-free milk (LFM). Conventionally, β-galactosidases catalyze the hydrolysis of lactose to produce glucose and galactose in LFM; however, they can also catalyze transgalactosylation reactions that produce a wide range o

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scheindlin, benjamin. "Lactose Intolerance and Evolution: No Use Crying Over Undigested Milk." Gastronomica 7, no. 2 (2007): 59–63. http://dx.doi.org/10.1525/gfc.2007.7.2.59.

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Lactose intolerance is an inability to digest milk sugar, characterized by abdominal cramps, nausea, and diarrhea after ingesting milk products. It develops in adolescence or adulthood among those whose bodies naturally stop producing the lactose-digesting enzyme lactase after childhood. Although uncommon in the United States, lactose intolerance actually occurs in the majority of people around the world. The ability to continue producing lactase, and thus to digest milk products, is a relatively recent evolutionary development. After presentation of an illustrative clinical example, the biolo

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Hegar, Badriul, and Hans A. Buller. "Breath Hydrogen Test in Lactose Malabsorption." Paediatrica Indonesiana 35, no. 7-8 (2018): 161–71. http://dx.doi.org/10.14238/pi35.7-8.1995.161-71.

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Lactose is the most important source in mammalian milk. In normal children, Lactose is hydrolyzed by lactase, and directly absorbed into bloodstream by an active transport mechanism. The term of lactose malabsorption is reserved to patients in whom impaired intestinal lactose hydrolysis and uptake has been proven by an appropriate test. The severity of lactose malabsorption and the extent of symptoms vary widely and are the results of several factors such as the amount of ingested lactose, gastric emptying time, intestinal transit time, and colonic flora. The diagnosis of lactose malabsorption

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Szilagyi, Andrew, Ian Shrier, Debra Heilpern, et al. "Differential Impact of Lactose/Lactase Phenotype on Colonic Microflora." Canadian Journal of Gastroenterology 24, no. 6 (2010): 373–79. http://dx.doi.org/10.1155/2010/649312.

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BACKGROUND: The ability to digest lactose divides the world’s population into two phenotypes that may be risk variability markers for several diseases. Prebiotic effects likely favour lactose maldigesters who experience lactose spilling into their colon.OBJECTIVE: To evaluate the effects of fixed-dose lactose solutions on fecal bifidobacteria and lactobacilli in digesters and maldigesters, and to determine whether the concept of a difference in ability to digest lactose is supported.METHODS: A four-week study was performed in 23 lactose mal-digesters and 18 digesters. Following two weeks of da

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Mendoza Torres, Evelyn, Lourdes Luz Varela Prieto, José Luis Villarreal Camacho, and Daniel Antonio Villanueva Torregroza. "Diagnosis of adult-type hypolactasia/lactase persistence: genotyping of single nucleotide polymorphism (SNP C/T-13910) is not consistent with breath test in Colombian Caribbean population." Arquivos de Gastroenterologia 49, no. 1 (2012): 5–8. http://dx.doi.org/10.1590/s0004-28032012000100002.

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CONTEXT: Genotyping of single nucleotide polymorphism (SNP C/T-13910) located upstream of the lactase gene is used to determine adult-type hypolactasia/lactase persistence in North-European Caucasian subjects. The applicability of this polymorphism has been studied by comparing it with the standard diagnostic methods in different populations. OBJECTIVE: To compare the lactose hydrogen breath test with the genetic test in a sample of the Colombian Caribbean population. METHODS: Lactose hydrogen breath test and genotyping of SNP C/T-13910 were applied to 128 healthy individuals (mean age 35 ± 1)

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Buzás, György Miklós. "A laktózintoleranciáról: Múlt és jelen – I. rész." Orvosi Hetilap 156, no. 38 (2015): 1532–39. http://dx.doi.org/10.1556/650.2015.30261.

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Lactose intolerance is the most prevalent intestinal malabsorption disorder. After presentation of its history, the author describes the emergence of lactose intolerance during the evolution of species, and the biochemistry of lactose as well as features of human and bacterial lactase enzymes are then described. The unequal distribution of lactose intolerance in different continents and population is discussed, followed by presentation of past and present prevalence data in Hungary. Adult-type hypolactasia is caused by a polymorphism of the MCM6 gene located upstream from the lactase gene on t

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Coluccia, Enza, Patrizia Iardino, Diego Pappalardo, et al. "Congruency of Genetic Predisposition to Lactase Persistence and Lactose Breath Test." Nutrients 11, no. 6 (2019): 1383. http://dx.doi.org/10.3390/nu11061383.

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The physiological decline of lactase production in adulthood, in some individuals, is responsible for the so-called “Lactose Intolerance.” This clinical syndrome presents with gastrointestinal and non-gastrointestinal symptoms following the consumption of dairy containing food. Lactose intolerance can be evaluated by means of the Lactose Breath Test (phenotype) and/or genetic evaluation of lactase-gene polymorphism (genotype). A comparison of the two tests was carried out in a large number of symptomatic adult subjects, which are selected and not representative of the general population. Congr

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Zhang, Ying, Mingjian Huang, Jianfeng Chen, Shuyuan Wang, and Jian Xu. "Relationship between Lactase Activity and Intestinal Flora Structure." Tobacco Regulatory Science 7, no. 5 (2021): 3104–9. http://dx.doi.org/10.18001/trs.7.5.1.81.

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To analyze and explore the relationship between lactase activity and the structure of intestinal flora in infants under 1 year old. Method: Our hospital selected 60 infants and young children in the Haizhu Maternity and Child Health Hospital from August 2019 to September 2020 as the research objects. The infants in the experimental group were diagnosed as lactose intolerant infants, the control group were normal infants, and the experimental group and control group had 30 cases each. The relationship between lactase activity and intestinal flora structure. Result: The experimental group had fe

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Alves, Sabrina Moreira dos Santos, Rafaela Machado Marques, Denise Gonçalves Costa Oliveira, and Tulio Cesar de Lima Lins. "Redução dos teores de lactose em leites com diferentes concentrações de gordura, fermentados por grãos de Kefir." Brazilian Journal of Food Research 11, no. 2 (2020): 1. http://dx.doi.org/10.3895/rebrapa.v11n2.11042.

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O Kefir é uma bebida fermentada de leite reconhecida como um alimento probiótico funcional e popularmente conhecida como de baixo teor de lactose. Objetivou-se analisar o teor de lactose em amostras de leite com diferentes concentrações de gordura, fermentadas por grãos de Kefir. O estudo experimental utilizou amostras de leites do tipo: Integral pasteurizado tipo C, integral tipo UHT, semidesnatado UHT e desnatado UHT, e seus respectivos Kefir fermentados por 24 horas. Para determinação de açúcares redutores em lactose foi utilizada titulometria pelo método Lane-Eynon e espectrofotometria enz

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Russette, Helen K., and Taeho Oh. "In Search of Lactose." Journal of Pharmacy Technology 12, no. 1 (1996): 16–20. http://dx.doi.org/10.1177/875512259601200106.

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Objective: To describe lactose in medications, answer commonly asked questions about lactose intolerance, and to provide useful information to pharmacists on how to identify lactose content in medications. Design: Descriptive. Summary: Within the population of lactose-intolerant individuals, a wide variation exists concerning the degree to which the lactase enzyme is deficient. When asked whether lactose-intolerant individuals can take their lactose-containing product without complications, the surveyed drug manufacturers offered a number of suggestions, including the following: avoid the prod

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Catanzaro, Roberto, Morena Sciuto, and Francesco Marotta. "Lactose Intolerance—Old and New Knowledge on Pathophysiological Mechanisms, Diagnosis, and Treatment." SN Comprehensive Clinical Medicine 3, no. 2 (2021): 499–509. http://dx.doi.org/10.1007/s42399-021-00792-9.

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AbstractLactose intolerance is a pathology frequently encountered today. It occurs when the activity of lactase in the intestine is reduced or absent, with consequent failure to digest lactose. The global prevalence of this clinical condition is estimated of about 57% with instrumental methods, while the real prevalence exceeds 65%. The absence of lactase determines both the excessive osmotic load in the small intestine and the fermentation of lactose by the bacterial flora with consequent production of short-chain fatty acids and gas. This latter process is responsible for the onset of sympto

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Pimentel, Grégory, Kathryn J. Burton, Marta Rosikiewicz, et al. "Blood lactose after dairy product intake in healthy men." British Journal of Nutrition 118, no. 12 (2017): 1070–77. http://dx.doi.org/10.1017/s0007114517003245.

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AbstractThe absence of a dedicated transport for disaccharides in the intestine implicates that the metabolic use of dietary lactose relies on its prior hydrolysis at the intestinal brush border. Consequently, lactose in blood or urine has mostly been associated with specific cases in which the gastrointestinal barrier is damaged. On the other hand, lactose appears in the blood of lactating women and has been detected in the blood and urine of healthy men, indicating that the presence of lactose in the circulation of healthy subjects is not incompatible with normal physiology. In this cross-ov

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Albuquerque, Alessandra Cristina Moraes, Michelline Lins Silvério, Vilma Sobral Bezerra, and Juliana Mendes Correia. "Produção e caracterização de queijo tipo ricota tratado com lactase." Research, Society and Development 11, no. 8 (2022): e50511830300. http://dx.doi.org/10.33448/rsd-v11i8.30300.

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O consumo excessivo de leite de origem animal pode levar ao surgimento da intolerância à lactose, decorrente da redução ou interrupção na produção da enzima lactase. Para atender a esse grupo de consumidores, a indústria alimentícia tem comercializado alguns laticínios sem lactose, entretanto além de serem insuficientes, possuem sabores pouco atrativos. Desta forma, o presente estudo se propôs a elaborar um laticínio sem lactose, mantendo os aspectos nutricionais, organolépticos, físico-químicos e microbiológicos atraentes ao consumidor portador de intolerância à lactose. Para realização do es

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Forget, P., J. Lombet, C. Grandfils, G. Dandrifosse, and F. Geubelle. "Lactase Insufficiency Revisited." Journal of Pediatric Gastroenterology and Nutrition 4, no. 6 (1985): 868–72. http://dx.doi.org/10.1002/j.1536-4801.1985.tb08979.x.

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The definition of “insufficient” small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test. Primary “insufficient” lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test. The lactase activity of 22 “normal” children ranged from 0.77 to 4.57 U/g wet weight, while five children showed primary lactase insufficiency as defined above

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