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Journal articles on the topic 'LAD-III'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Etzioni, Amos, and Ronen Alon. "LAD III versus LAD I variant." Blood 110, no. 12 (2007): 4129. http://dx.doi.org/10.1182/blood-2007-05-089227.

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2

van de Vijver, Edith, Iris M. De Cuyper, Anja J. Gerrits та ін. "Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin β1 and β3 in platelet adhesion to collagen". Blood 119, № 2 (2012): 583–86. http://dx.doi.org/10.1182/blood-2011-02-337188.

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Abstract Patients with Glanzmann thrombasthenia or Leukocyte Adhesion Deficiency-III syndrome (LAD-III or LAD-1/variant) present with increased bleeding tendency because of the lack or dysfunction of the fibrinogen receptor GPIIb/IIIa (integrin αIIbβ3), respectively. Although the bleeding disorder is more severe in LAD-III patients, classic aggregometry or perfusion of Glanzmann or LAD-III platelets over collagen-coated slides under physiologic shear rate does not discriminate between these 2 conditions. However, in a novel flow cytometry-based aggregation assay, Glanzmann platelets were still

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3

Pasvolsky, Ronit, Sara W. Feigelson, Sara Sebnem Kilic, et al. "A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets." Journal of Experimental Medicine 204, no. 7 (2007): 1571–82. http://dx.doi.org/10.1084/jem.20070058.

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Leukocyte and platelet integrins rapidly alter their affinity and adhesiveness in response to various activation (inside-out) signals. A rare leukocyte adhesion deficiency (LAD), LAD-III, is associated with severe defects in leukocyte and platelet integrin activation. We report two new LAD cases in which lymphocytes, neutrophils, and platelets share severe defects in β1, β2, and β3 integrin activation. Patients were both homozygous for a splice junction mutation in their CalDAG-GEFI gene, which is a key Rap-1/2 guanine exchange factor (GEF). Both mRNA and protein levels of the GEF were diminis

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4

Sidhu, Navdeep Singh, and Gagandeep Singh Wander. "Prevalence and characteristics of dual left anterior descending artery in adult patients undergoing coronary angiography." Future Cardiology 15, no. 6 (2019): 425–35. http://dx.doi.org/10.2217/fca-2019-0052.

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Aim: To determine the prevalence and characteristics of dual left anterior descending artery (LAD) in adults undergoing catheter coronary angiography. Materials & methods: We identified cases with dual LAD by retrospectively analyzing 3233 angiograms done from January 2017 to June 2019. Results: Dual LAD was seen in 22 patients (0.68%). We identified type I dual LAD in 14 cases, type II in 7 cases and type III in 1 case. Significant stenosis was seen in proximal part of long LAD in 12 cases, in LAD proper in 7 cases and in proximal part of short LAD in 4 cases. Conclusion: Dual LAD is a ra

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5

Manevich-Mendelson, Eugenia, Sara W. Feigelson, Ronit Pasvolsky, et al. "Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions." Blood 114, no. 11 (2009): 2344–53. http://dx.doi.org/10.1182/blood-2009-04-218636.

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Abstract Leukocyte adhesion deficiency (LAD)–III is associated with homozygous stop codon mutations in Kindlin-3, the hematopoietic member of the Kindlin family of integrin coactivators. In addition, a subgroup of LAD-III patients has a homozygous splice junction mutation in and reduced expression of the Rap-1 guanine nucleotide exchange factor, CalDAG-GEFI (CDGI). In this study, we compared the adhesive properties of the leukocyte function-associated antigen-1 (LFA-1) and very late activation antigen-4 (VLA-4) integrins in both primary and activated leukocytes derived from these 2 LAD-III sub

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6

McDowall, Alison, Lena Svensson, Paula Stanley, et al. "Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro." Blood 115, no. 23 (2010): 4834–42. http://dx.doi.org/10.1182/blood-2009-08-238709.

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Abstract In the disorder leukocyte adhesion deficiency III (LAD-III), integrins on platelets and leukocytes are expressed but fail to function and this leads to severe bleeding and infections at an early age. Mutation in the KINDLIN3 (FERMT3) gene is the cause of LAD-III in patients from the Middle East, Malta, and Turkey. We describe 2 novel homozygous mutations in the KINDLIN3 gene of a new African-American patient that destabilize KINDLIN3 mRNA leading to loss of kindlin-3 protein. Transfection of wild-type (WT) KINDLIN3 cDNA restored integrin-related adhesion and migration in the LAD-III p

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7

Jurk, Kerstin, Ansgar Schulz, Beate Kehrel, et al. "Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3." Thrombosis and Haemostasis 103, no. 05 (2010): 1053–64. http://dx.doi.org/10.1160/th09-10-0689.

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SummaryLeukocyte adhesion deficiency-III (LAD-III) also called leukocyte adhesion deficiency-1/variant (LAD1v) is a rare congenital disease caused by defective integrin activation of leukocytes and platelets. Patients with LAD-III present with non-purulent infections and increased bleeding symptoms. We report on a novel integrin-dependent platelet dys-function in two brothers with LAD-III syndrome caused by a homozygous mutation 1717C>T in the FERMT3 gene leading to a premature stop codon R573X in the focal adhesion protein kindlin-3. Stimulation of patients´ platelets with all used agonist

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8

Kinashi, Tatsuo, Memet Aker, Maya Sokolovsky-Eisenberg, et al. "LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds." Blood 103, no. 3 (2004): 1033–36. http://dx.doi.org/10.1182/blood-2003-07-2499.

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AbstractRecently, we reported a rare leukocyte adhesion deficiency (LAD) associated with severe defects in integrin activation by chemokine signals, despite normal ligand binding of leukocyte integrins.1 We now report that the small GTPase, Rap1, a key regulator of inside-out integrin activation is abnormally regulated in LAD Epstein-Barr virus (EBV) lymphocyte cells. Both constitutive and chemokine-triggered activation of Rap1 were abolished in LAD lymphocytes despite normal chemokine signaling. Nevertheless, Rap1 expression and activation by phorbol esters were intact, ruling out an LAD defe

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9

Alon, Ronen, and Amos Etzioni. "LAD-III, a novel group of leukocyte integrin activation deficiencies." Trends in Immunology 24, no. 10 (2003): 561–66. http://dx.doi.org/10.1016/j.it.2003.08.001.

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10

Brandt, Simon D., Pierce V. Kavanagh, Folker Westphal, et al. "Return of the lysergamides. Part III: Analytical characterization of N 6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD)." Drug Testing and Analysis 9, no. 10 (2017): 1641–49. http://dx.doi.org/10.1002/dta.2196.

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11

Harris, Estelle S., Tammy L. Smith, Gregory M. Springett, Andrew S. Weyrich, and Guy A. Zimmerman. "Leukocyte adhesion deficiency-I variant syndrome (LAD-Iv, LAD-III): Molecular characterization of the defect in an index family." American Journal of Hematology 87, no. 3 (2011): 311–13. http://dx.doi.org/10.1002/ajh.22253.

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12

Zhu, Pengxiong, Xiaofeng Ye, Anqing Chen, et al. "Does the site of coronary endarterectomy have an impact on the clinical outcomes and graft patency?" Interactive CardioVascular and Thoracic Surgery 29, no. 3 (2019): 402–8. http://dx.doi.org/10.1093/icvts/ivz099.

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AbstractOBJECTIVESTo explore whether coronary endarterectomy (CE) sites have obvious impacts on the clinical outcomes and graft patency in off-pump coronary artery bypass (OPCAB).METHODSThe patients who underwent OPCAB with CE in our unit between January 2009 and December 2016 were included. The patients and the grafts were grouped according to the CE sites. The primary end points were mid-term main adverse cardiovascular and cerebrovascular events.RESULTSIn total, 290 patients who underwent OPCAB with CE were included. CE of the left anterior descending artery (LAD), left circumflex artery an

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13

Mori, A. "Kindlin 3 - A new gene involved in the pathogenesis of LAD III." La Revue de Médecine Interne 30 (February 2009): 11–12. http://dx.doi.org/10.1016/s0248-8663(09)72100-9.

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14

MOERK, E. "The LAD was a lady and the tasks were III-defined*1." Developmental Review 9, no. 1 (1989): 21–57. http://dx.doi.org/10.1016/0273-2297(89)90022-1.

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15

Mory, Adi, Sara W. Feigelson, Nese Yarali, et al. "Kindlin-3: a new gene involved in the pathogenesis of LAD-III." Blood 112, no. 6 (2008): 2591. http://dx.doi.org/10.1182/blood-2008-06-163162.

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16

Pimont, François, Maxime Soma, and Jean-Luc Dupuy. "Accounting for Wood, Foliage Properties, and Laser Effective Footprint in Estimations of Leaf Area Density from Multiview-LiDAR Data." Remote Sensing 11, no. 13 (2019): 1580. http://dx.doi.org/10.3390/rs11131580.

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The spatial distribution of Leaf Area Density (LAD) in a tree canopy has fundamental functions in ecosystems. It can be measured through a variety of methods, including voxel-based methods applied to LiDAR point clouds. A theoretical study recently compared the numerical errors of these methods and showed that the bias-corrected Maximum Likelihood Estimator was the most efficient. However, it ignored (i) wood volumes, (ii) vegetation sub-grid clumping, (iii) the instrument effective footprint, and (iv) was limited to a single viewpoint. In practice, retrieving LAD is not straightforward, becau

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17

Kahraman, Serkan, Hakan Ucar, Sinem Ozyılmaz, Samir Allahverdiyev, and Emrah Ermis. "Triple Coronary Artery Thrombosis Presenting as Acute Anterior ST-Segment Elevation Myocardial Infarction." International Journal of Angiology 27, no. 04 (2017): 223–26. http://dx.doi.org/10.1055/s-0037-1608959.

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AbstractSimultaneous multivessel epicardial coronary artery thrombosis is an uncommon finding in acute ST-segment elevation myocardial infarction (STEMI). It generally leads to cardiogenic shock and sudden cardiac death in the hospital. We report a 42-year-old male patient presenting with acute anterior STEMI with triple coronary artery thrombosis. An emergency coronary angiogram showed total occlusion of the left anterior descending artery (LAD) with thrombus formation. At the same time, thrombus formations were also seen in the circumflex artery (CXA), the second obtuse marginal (OM2) branch

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18

Ali, Nasir, Faiq Ahmed Khan, Asif Mahmood Janjua, Ala Eldin, Muhammad Ashfaq, and Kifayatullah . "LONGEST LAD ENDARTRECTOMY RECORDED AND DOCUMENTED TILL DATE IN AFIC/NIHD." Pakistan Armed Forces Medical Journal 70, Suppl-4 (2021): S904–06. http://dx.doi.org/10.51253/pafmj.v70isuppl-4.6008.

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As the world advances, living standards are getting changed with inclination more toward sedentary life style and junk food, we are seeing a worldwide increased incidence of coronary artery disease. A 73 year of age gentleman with progressive shortness of breath NYHA-II/III since last 6 months and epigastric discomfort with effort angina CCS-III. Was having no other co-morbidities, except of 35 pack years of smoking. On evaluation his Coro-angiogram revealed Diffuses TVCAD with Lad diffusely diseased throughout its middle course >90%, LCX 80%, RCA mid-Course critical discrete lesion of 90%.

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19

Elveos, Marlene Mauseth, Jon Olav Drogset, Lars Engebretsen, Raymond Brønn, Trond Olav Lundemo, and Tone Gifstad. "Anterior Cruciate Ligament Reconstruction Using a Bone–Patellar Tendon–Bone Graft With and Without a Ligament Augmentation Device: A 25-Year Follow-up of a Prospective Randomized Controlled Trial." Orthopaedic Journal of Sports Medicine 6, no. 11 (2018): 232596711880877. http://dx.doi.org/10.1177/2325967118808778.

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Background: Various grafts and ligament augmentation devices (LADs) have been used in the search for optimal reconstruction of the anterior cruciate ligament (ACL). Purpose: To compare 25-year follow-up results after ACL reconstruction using a bone–patellar tendon–bone (BPTB) graft with or without the Kennedy LAD. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: One hundred patients undergoing ACL reconstruction between 1991 and 1993 were randomized into 2 groups: reconstruction using a BPTB graft alone (BPTB group, 51 patients) or a BPTB graft with the Kennedy LAD (LA

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20

Patyna, Michael, Vicky Ehlers, Benjamin Bahlmann, and Adrian Kasaj. "Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study." Clinical Oral Investigations 25, no. 6 (2021): 3967–75. http://dx.doi.org/10.1007/s00784-020-03727-1.

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Abstract Objectives The aim of this pilot study was to evaluate the clinical and microbiological outcomes of light-activated disinfection (LAD) alone or combined with probiotics as an adjunct to non-surgical periodontal treatment. Materials and methods In this single-blinded, randomized, controlled clinical pilot study, 48 patients (28 females and 20 males) with untreated periodontitis (stages II and III, grade B) were included. Using a parallel-group design, patients were randomly assigned into 3 groups to receive subgingival debridement (SD) alone (group 1, n = 16), SD with LAD (group 2, n =

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21

Schmid, Peter, Michael Untch, Valentin Kossé, et al. "Leuprorelin Acetate Every-3-Months Depot Versus Cyclophosphamide, Methotrexate, and Fluorouracil As Adjuvant Treatment in Premenopausal Patients With Node-Positive Breast Cancer: The TABLE Study." Journal of Clinical Oncology 25, no. 18 (2007): 2509–15. http://dx.doi.org/10.1200/jco.2006.08.8534.

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Purpose Ovarian suppression with luteinizing hormone–releasing hormone (LHRH) agonists is an effective adjuvant treatment for premenopausal women with estrogen receptor (ER) –positive breast cancer. Whereas monthly LHRH agonist therapy has been well established, the value of every-3-months (3-monthly) formulations is unclear. Patients and Methods This randomized phase III trial was performed to compare the 3-monthly depot LHRH agonist leuprorelin acetate (LAD-3M; n = 299) and chemotherapy with cyclophosphamide, methotrexate, and fluorouracil (CMF; n = 300) in pre- or perimenopausal patients wi

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22

Kilic, Sara S., and Amos Etzioni. "The Clinical Spectrum of Leukocyte Adhesion Deficiency (LAD) III due to Defective CalDAG-GEF1." Journal of Clinical Immunology 29, no. 1 (2008): 117–22. http://dx.doi.org/10.1007/s10875-008-9226-z.

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23

Feigelson, Sara W., Valentin Grabovsky, Eugenia Manevich-Mendelson, et al. "Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells." Blood 117, no. 26 (2011): 7042–52. http://dx.doi.org/10.1182/blood-2010-12-322859.

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Kindlin-3 is a key lymphocyte function–associated antigen-1 (LFA-1) coactivator deleted in leukocyte adhesion deficiency-III (LAD-III). In the present study, we investigated the involvement of this adaptor in lymphocyte motility and TCR-triggered arrest on ICAM-1 or on dendritic cells (DCs). Kindlin-3–null primary T cells from a LAD-III patient migrated normally on the major lymph node chemokine CCL21 and engaged in normal TCR signaling. However, TCR activation of Kindlin-3–null T lymphocytes failed to trigger the robust LFA-1–mediated T-cell spreading on ICAM-1 and ICAM-1–expressing DCs that

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Goldstein, D., N. Spry, G. Van Hazel, et al. "Combined modality therapy for pancreatic carcinoma: An Australian Pancreatic Cancer Group study of the addition of gemcitabine (G) to concurrent infusional 5-fluorouracil (CI 5FU) and 3D conformal radiotherapy (RT)—Final outcomes." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4104. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4104.

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4104 Background: This open-label Phase II study (B9E-AY-S168) examined whether CI 5FU plus 3D conformal planning RT is well tolerated and may be combined with G pre and post chemoradiotherapy in patients (pts) with pancreatic cancer (PC). Methods: Eligible pts were enrolled in two strata: (1) inoperable PC in head or body without metastases (LAD) or (2) resected PC at high risk of relapse (Surg). G was given at 1000 mg/m2 weekly for 3 wks followed by 1 wk rest and a 5–6 wk period of RT and concurrent CI 5FU (200 mg/m2/day). The defined target volume was treated to 54Gy in 30# of 1.8Gy (LAD) or

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Singh, Abhishek, Sudhanshu Dwivedi, Akshyaya Pradhan, et al. "Isolated ST-Elevation Myocardial Infarction Involving Leads I and aVL: Angiographic and Electrocardiographic Correlations from a Tertiary Care Center." Cardiology Research and Practice 2021 (June 21, 2021): 1–7. http://dx.doi.org/10.1155/2021/7638020.

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Background. Determining the infarct-related artery in STEMI during a coronary angiogram can be challenging due to the affliction of multiple vessels. Isolated STEMI involving only EKG leads I and aVL is infrequent. Localization of infarct-related artery based on EKG findings has not been previously done in this subset. Methods. All consecutive de novo acute coronary syndrome (ACS) patients admitted to coronary care unit with ST elevations involving only leads I and aVL were screened for enrollment. Patients with ST elevation in any additional lead and those who refused a coronary angiogram wer

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Chou, Szu-Hsien, Kuan-Yu Lin, Zhen-Ye Chen, Chun-Jung Juan, Chien-Yi Ho, and Tzu-Ching Shih. "Integrating Patient-Specific Electrocardiogram Signals and Image-Based Computational Fluid Dynamics Method to Analyze Coronary Blood Flow in Patients during Cardiac Arrhythmias." Journal of Medical and Biological Engineering 40, no. 2 (2019): 264–72. http://dx.doi.org/10.1007/s40846-019-00504-8.

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Abstract Purpose The aim of this study was to use the computational fluid dynamics (CFD) method, patient-specific electrocardiogram (ECG) signals, and computed tomography three-dimensional image reconstruction technique to investigate the blood flow in coronary arteries during cardiac arrhythmia. Methods Two patients with premature ventricular contraction-type cardiac arrhythmia and one with atrial fibrillation-type cardiac arrhythmia were investigated. The inlet velocity of the coronary artery in simulation was applied with the measured velocity profile of the left ventricular outflow tract (

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27

Bergmeier, Wolfgang, Tobias Goerge, Hong-Wei Wang, et al. "Mice Lacking the Signaling Molecule, CalDAG-GEFI, Represent a Mouse Model for Leukocyte Adhesion Deficiency Type III." Blood 108, no. 11 (2006): 674. http://dx.doi.org/10.1182/blood.v108.11.674.674.

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Abstract Defective inside-out activation of β 1, β 2, and β 3 integrins in platelets and leukocytes is a main characteristic of patients with leukocyte adhesion deficiency (LAD)-III syndrome. We have recently shown that CalDAG-GEFI, a member of the CalDAG-GEF/RasGRP family of intracellular signaling molecules that catalyzes the exchange of GTP for GDP bound to Rap1, plays a key role for the activation of α IIbβ 3 in murine platelets. Here we studied the role of CalDAG-GEFI for neutrophil function as well as the activation of β 1 integrins in platelets. Neutrophils from CalDAG-GEFI−/ − mice sho

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28

Tramboo, Nisar Ahmad, Khurshid Iqbal, Suresh Koul, et al. "An Unprotected Distal Left Main Disease Treated with Stenting- A Maiden Experience at a Tertiary Care Center." JMS SKIMS 13, no. 1 (2010): 25–27. http://dx.doi.org/10.33883/jms.v13i1.41.

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Unprotected left main disease which till recently was considered a class III indication for PCI has been accepted as a IIb indication in the last updated AHA/ACC guidelines. Now world over , UPLM stenting is being increasingly taken up , especially after the entry of drug eluting stents in the coronary interventional arena. The distal left main disease is considered the technically most challenging. We present here a case of distal left main disease with critical ostial LAD and LCX disease, successfully managed with stenting via the double barrel technique. J Med Sci 2010;13(1):25-27

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da Costa, Alexandre Andre Balieiro Anastacio, Adriana Regina G. Ribeiro, Andrea Paiva Guimaraes, Ludmilla Thome Chinen, Clovis Pinto, and Vladmir C. Lima. "EGFRv3 and PTEN as prognostic markers in head and neck squamous cell carcinoma patients treated with cetuximab." Journal of Clinical Oncology 31, no. 15_suppl (2013): e17032-e17032. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e17032.

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e17032 Background: Cetuximab (CTx) is used in treatment of locally advanced (LAD) head and neck squamous cell carcinoma (HNSCC) in combination with radiotherapy (RT) or in metastatic disease (MD). There is no comparison between CTx plus RT and cisplatin plus RT. Patients treated with CTx in daily clinical practice are frequently different from the selected population treated in clinical trials. There are no biomarkers for efficacy of CTx in HNSCC. EGFR variant 3 mutation (EGFRv3), an extracellular domain mutation of EGFR, has been reported in different frequencies in HNSCC in the last years an

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Goerge, T., W. Bergmeier, H. Wang, et al. "CALDAG-GEFI-DEFICIENCY CAUSES IMPAIRED BETA1, BETA2, AND BETA3 INTEGRIN ACTIVATION IN NEUTROPHILS AND PLATELETS: A MODEL FOR LEUKOCYTE ADHESION DEFICIENCY-III (LAD-III)." Journal of Thrombosis and Haemostasis 5 (July 2007): P—T—278—P—T—278. http://dx.doi.org/10.1111/j.1538-7836.2007.tb02036.x.

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Chan, Tabitha Y., Poh Wee Tan, Chek Wee Tan, and Johann I. Tang. "Dosimetric evaluation of organs at risk to toxicities between multicatheter accelerated partial-breast irradiation and whole-breast external beam radiotherapy." Journal of Clinical Oncology 32, no. 26_suppl (2014): 94. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.94.

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94 Background: This study aims to quantify the dosimetric reduction to the heart and lung when comparing Whole Breast External Beam Radiotherapy(WBEBRT) with Multicatheter Accelerated Partial Breast Irradiation(MCAPBI) for early stage left sided breast cancer. Methods: Planning CT data sets of 13 patients with left breast cancer receiving multicatheter brachytherapy post breast conserving surgery were used to create two independent treatment plans – WBEBRT prescribed to 50Gy/25fractions and MCAPBI prescribed to 34Gy/10fractions. Dose parameters for (i) heart, (ii) left anterior descending(LAD)

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Zaman, SM Mustafa, Masud Sinha, Prodip Kumar Karmakar, Sufia Rahman, Md Harisul Hoque, and Ariful Islam Joarder. "Left main coronary angioplasty A case report." University Heart Journal 5, no. 1 (2009): 40–41. http://dx.doi.org/10.3329/uhj.v5i1.3441.

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A 52 years lady presented with chest pain and shortness of breath. Chest pain was initially CCS class II and gradually CCS class III. Coronary angiogram reveals triple vessel disease for which she underwent CABG (RSVG to LAD) in December 1999. On January 2003 PTCA with stent (sirolimus - 3 x 15m m) to LCX was done. She again complaints of chest pain after a short symptom less period. Recent coronary angiogram revealed TVD with left main involvement. In this article we will describe a rare case of successful stenting in left main disease. doi: 10.3329/uhj.v5i1.3441 University Heart Journal Vol.

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Vrachnis, Nikolaos, Dimitrios Zygouris, Dionysios Vrachnis, et al. "Perinatal Inflammation: Could Partial Blocking of Cell Adhesion Molecule Function Be a Solution?" Children 8, no. 5 (2021): 380. http://dx.doi.org/10.3390/children8050380.

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In spite of the great advances made in recent years in prenatal and perinatal medicine, inflammation can still frequently result in injury to vital organs and often constitutes a major cause of morbidity. It is today well established that in neonates—though vulnerability to infection among neonates is triggered by functional impairments in leukocyte adhesion—the decreased expression of cell adhesion molecules also decreases the inflammatory response. It is also clear that the cell adhesion molecules, namely, the integrins, selectins, and the immunoglobulin (Ig) gene super family, all play a cr

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Pasvolsky, Ronit, Sara W. Feigelson, Sara Sebnem Kilic, et al. "A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets." Journal of Cell Biology 178, no. 1 (2007): i2. http://dx.doi.org/10.1083/jcb1781oia2.

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35

Alders, David J. C., A. B. Johan Groeneveld, Thomas W. Binsl, and Johannes H. G. M. van Beek. "Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 10 (2015): H1708—H1719. http://dx.doi.org/10.1152/ajpheart.00657.2014.

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In normal hearts, myocardial perfusion is fairly well matched to regional metabolic demand, although both are distributed heterogeneously. Nonuniform regional metabolic vulnerability during coronary stenosis would help to explain nonuniform necrosis during myocardial infarction. In the present study, we investigated whether metabolism-perfusion correlation diminishes during coronary stenosis, indicating increasing mismatch of regional oxygen supply to demand. Thirty anesthetized male pigs were studied: controls without coronary stenosis ( n = 11); group I, left anterior descending (LAD) corona

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Suryono, Suryono, Naesilla Naesilla, Ika Aulia Kurniasari, et al. "Percutaneous Coronary Intervention in Post-Infarction Ventricular Septal Rupture." Health Notions 5, no. 4 (2021): 146–50. http://dx.doi.org/10.33846/hn50407.

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Background: Ventricular septal rupture (VSR) is a fatal mechanical complication following acute myocardial infarction (AMI). The definitive treatment remains surgical repair, however several aspects are still debatable, including the timing of surgery. Patient’s refusal of treatment and lack of medical facilities put other challenges in management of VSR. Case presentation: A-48-year-old male with a history of diabetes mellitus and hypertension came with a late-presentation anterior AMI, and refused the reperfusion therapy. By the third day, he developed VSR and cardiogenic shock. The patient

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Islam, AHMW, S. Munwar, S. Talukder, AQM Reza, T. Ahmed, and AH Bhuiyan. "Slender Percutaneous Coronary Intervention (Slender PCI) via Transradial approach by using 5Fr Guide Catheter- An Updated Single Center Experiences." Cardiovascular Journal 5, no. 2 (2013): 160–64. http://dx.doi.org/10.3329/cardio.v5i2.14320.

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Background: Aim of the study was to evaluate the primary procedural success of slender PCI via transradial approach using either Bare-metal stents (BMS) or Drug Eluting Stent (DES). Methods: Total 10 patients were enrolled in this very preliminary study. Among them, Male: 8 and Female: 2. Clinical presentation were Ant MI: 4 (40%), Inf. MI: 2 (20%), Angina II-III: 3 (30%), and NSTEMI: 1 (10%). Total 10 stents were deployed. Mean age were for Male: 44yrs, for Female: 55yrs . Associated CAD risk factors were Dyslipidemia, High Blood pressure, Diabetes Mellitus, Positive FH for CAD and Smoking (a

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Alghamri, Mahmoud S., Mariana Morris, J. Gary Meszaros, Khalid M. Elased, and Nadja Grobe. "Novel role of aminopeptidase-A in angiotensin-(1–7) metabolism post myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 7 (2014): H1032—H1040. http://dx.doi.org/10.1152/ajpheart.00911.2013.

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Aminopeptidase-A (APA) is a less well-studied enzyme of the renin-angiotensin system. We propose that it is involved in cardiac angiotensin (ANG) metabolism and its pathologies. ANG-(1–7) can ameliorate remodeling after myocardial injury. The aims of this study are to 1) develop mass spectrometric (MS) approaches for the assessment of ANG processing by APA within the myocardium; and 2) investigate the role of APA in cardiac ANG-(1–7) metabolism after myocardial infarction (MI) using sensitive MS techniques. MI was induced in C57Bl/6 male mice by ligating the left anterior descending (LAD) arte

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Puetz, John, and Mary Boudreaux. "Evaluation of the Gene Encoding Calcium Diacylglycerol Guanine Nucleotide Exchange Factor I (CalDAG-GEFI) in Human Patients with Congenital Qualitative Platelet Disorders." Blood 114, no. 22 (2009): 5078. http://dx.doi.org/10.1182/blood.v114.22.5078.5078.

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Abstract Abstract 5078 Normal platelet function is dependent on an orchestrated series of interactions resulting in primary hemostasis. Dysfunction in any step of platelet activation and aggregation results in abnormal platelet function and abnormal mucocutaneous bleeding. Defects in agonist/receptor interactions, membrane phospholipid and cytoskeleton structure, signal transduction, storage pool content and release have all been described. While some congenital qualitative platelet function disorders such as Bernard-Soulier syndrome or Glanzmann thrombasthenia are well characterized at the mo

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Chen, Alvin S., Rachel E. Bent, Matthew Wheeler, et al. "Large Q and S waves in lead III on the electrocardiogram distinguish patients with hypertrophic cardiomyopathy from athletes." Heart 104, no. 22 (2018): 1871–77. http://dx.doi.org/10.1136/heartjnl-2017-312647.

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ObjectiveTo identify electrocardiographic findings, especially deep Q and S waves in lead III, that differentiate athletes from patients with hypertrophic cardiomyopathy (HCM).MethodsDigital ECGs of athletes and patients with HCM followed at the Stanford Center for Inherited Cardiovascular Disease were studied retrospectively. All patients with HCM had an echocardiogram performed. A multivariable logistic regression model was used to calculate ORs for various demographic and ECG characteristics. Linear regression was used to correlate ECG characteristics with echocardiogram findings.ResultsWe

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Abouliatim, Issam, Majid Harmouche, Agnès Drochon, Mahmoud Maasrani, Hervé Corbineau, and Jean-Philippe Verhoye. "Coronary Flow in Patients with Three-Vessel Disease: Simulated Hemodynamic Variables in relation to Angiographically Assessed Collaterality and History of Myocardial Infarction." ISRN Vascular Medicine 2011 (January 5, 2011): 1–10. http://dx.doi.org/10.5402/2011/470313.

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We study patients with stenoses of the left main coronary artery (LMCA), left anterior descending artery (LAD), and left circumflex branch (LCx) and with chronic occlusion of the right coronary artery (RCA), undergoing off-pump coronary surgery. An analog electrical model is used to provide quantitative estimations of the distribution of flows and pressures across the coronary network (in the stenosed native arteries, the collateral branches, the capillary areas, and so forth). The present paper demonstrates that the clinical information collected for the 10 patients included in the study (Ren

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Schloemer, Nathan J., Alex M. Abel, Monica S. Thakar, Yan-Qing Ma, and Subramaniam Malarkannan. "Impact of Kindlin-3 in NK Cell-Mediated Anti-Tumor Cytotoxicity and Inflammatory Cytokine Production." Blood 126, no. 23 (2015): 208. http://dx.doi.org/10.1182/blood.v126.23.208.208.

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Abstract Natural Killer (NK) cells are innate lymphocytes that play a central role in anti-viral and anti-tumor responses through direct cytotoxicity and production of inflammatory cytokines. Tumors can evade T-cell mediated immune-surveillance by down-regulation of the Class I Major Histocompatibility Complex (MHC-I) (Haworth et al, Ped Blood and Cancer, 2015). However, this lack of 'self' MHC-I serves as an activation stimulus for NK cells to recognize tumor cells. The molecular mechanism for 'self' recognition and destruction of 'missing self' are poorly understood. Integrins facilitate cel

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Surdacki, Michał A., Marcin Major, Michał Chyrchel, et al. "Urgent Pericardiocentesis Is More Frequently Needed After Left Circumflex Coronary Artery Perforation." Journal of Clinical Medicine 9, no. 9 (2020): 3043. http://dx.doi.org/10.3390/jcm9093043.

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Background: Coronary artery perforation (CAP) is a rare but potentially life-threatening complication of percutaneous coronary interventions (PCIs) due to the risk of cardiac tamponade. Strikingly, in contrast to numerous analyses of CAP predictors, only few studies were focused on the predictors of tamponade after PCI, once iatrogenic CAP has occurred. Our aim was to search for clinical and periprocedural characteristics, including the coronary artery involved, associated with the development of acute cardiac tamponade among patients experiencing CAP. Methods: From the medical records of nine

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Shenouda, Rafik, Ibadete Bytyçi, Mohamed Sobhy, and Michael Y. Henein. "Early Recovery of Left Ventricular Function After Revascularization in Acute Coronary Syndrome." Journal of Clinical Medicine 9, no. 1 (2019): 24. http://dx.doi.org/10.3390/jcm9010024.

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The aim of this study was to assess the accuracy of echocardiographic techniques in detecting the early recovery of left ventricular (LV) function after revascularization in acute coronary syndrome (ACS). In 80 consecutive patients with ACS (age 55.7 ± 9.4 years, 77% male, 15% with CCS Angina III), an echocardiographic examination of left ventricle regional wall motion abnormalities (LV RWMA), peak systolic strain rate (PSSR), peak systolic strain (PSS) and end systolic strain (ESS) was performed before and after percutaneous intervention (PCI). Of the 80 patients, one vessel stenosis (>70%

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Razzaque, M., JL Philip, X. Xu, M. Han, J. Li, and SA Akhter. "ID: 137: GRK2 INHIBITION REDUCES POST-MYOCARDIAL INFARCTION CARDIAC FIBROBLAST MEDIATED ADVERSE REMODELING." Journal of Investigative Medicine 64, no. 4 (2016): 912.1–912. http://dx.doi.org/10.1136/jim-2016-000120.3.

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ObjectivesRemote (non-infarct) territory fibrosis is a significant cause of post-infarction heart failure (HF). We have previously shown that increased G protein-coupled receptor kinase-2 (GRK2) activity in adult human cardiac fibroblasts (CF) isolated from failing hearts is an important mechanism of cardiac fibrosis through uncoupling β-adrenergic receptor (β-AR) signaling. This study investigates the potential therapeutic role of GRK2 inhibition on CF biology in vivo.MethodsAdult male rats underwent LAD ligation to induce post-MI HF. Left ventricular (LV) function was assessed by echocardiog

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Singh, Manoj Kumar, and Ashish K. Dash. "Local Area Development through Hydropower Project: A Case Study of Parbati Hydro-electric Project Stage-III (520MW) in Kullu District of Himachal Pradesh India." International Journal of Community Development 5, no. 1 (2017): 1. http://dx.doi.org/10.11634/233028791503892.

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Hydropower is considered as renewable, cheap and pollution free source of energy in comparison to conventional source of energy. The major river system and topographical variation in Indian Himalayan Region(IHR) offer huge hydroelectric potential because of available net head and water discharge. Efforts are being made for sustainable harnessing of hydroelectric potential of IHR to meet the gap between demand and supply of electricity. Most of these hydropower sites are located in remote hilly terrain of IHR with limited infrastructure like access road, market, hospital etc. For timely executi

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Roth, Benjamin D., Adam A. Goodenough, Scott D. Brown, Jan A. van Aardt, M. Grady Saunders, and Keith Krause. "Simulations of Leaf BSDF Effects on Lidar Waveforms." Remote Sensing 12, no. 18 (2020): 2909. http://dx.doi.org/10.3390/rs12182909.

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Establishing linkages between light detection and ranging (lidar) data, produced from interrogating forest canopies, to the highly complex forest structures, composition, and traits that such forests contain, remains an extremely difficult problem. Radiative transfer models have been developed to help solve this problem and test new sensor platforms in a virtual environment. Many forest canopy studies include the major assumption of isotropic (Lambertian) reflecting and transmitting leaves or non-transmitting leaves. Here, we study when these assumptions may be valid and evaluate their associa

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Islam, Shitil Ibna, Md Nurul Amin, Sahela Nasrin, and F. Aaysha Cader. "Variation in Coronary Artery Disease Pattern and Risk Factors among Female Patients of Dierent Age Groups in Bangladesh." Ibrahim Cardiac Medical Journal 9, no. 1-2 (2020): 60–66. http://dx.doi.org/10.3329/icmj.v9i1-2.53992.

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Background & objective: Coronary Artery Disease (CAD) is a devastating life-threatening condition which varies with respect to age and sex. In Bangladesh a large number of patients currently undergoes coronary angiography for a variety of indications. Due to physiological changes after menopause, the females are more prone to develop CAD. So, the risk factors and pattern of CAD in female are subject change with changing ages. The objective of this study was to compare the risk factors and pattern of CAD in female patients of different age groups. Methods: This cross-sectional analyti

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Islam, AHM Waliul, Shams Munwar, AQM Reza, et al. "Percutaneous Coronary Intervention of Saphenous Vein Graft in Post-CABG Patients- Experience at a Tertiary Cardiac Centre." Bangladesh Heart Journal 35, no. 1 (2020): 6–13. http://dx.doi.org/10.3329/bhj.v35i1.49137.

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Background: Percutaneous Coronary Intervention (PCI) of obstructed & atheromatous venous graft is a real challenge for interventionist to deal with as SVG PCI patients are usually older with significant coronary & non coronary comorbidities. SVG usually presents a degenerated pattern of atherosclerosis with complex friable thrombosis prone lesions, higher risk of distal embolization, poorer long-term outcome with higher ISR rate Objectives: In the current era, with the advent and availability of different Drug Eluting Stents, PCI of SVG vessel is an alternative to re-do surgery f

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Liu, Xiaoxiao, Yifeng Xu, Yunfei Deng, and Hongli Li. "MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1." Cellular Physiology and Biochemistry 46, no. 4 (2018): 1439–54. http://dx.doi.org/10.1159/000489185.

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Background/Aims: Percutaneous coronary intervention reduces acute myocardial infarction (MI)-induced mortality to a great extent, but effective treatments for MI-induced cardiac fibrosis and heart failure are still lacking. MicroRNAs (miRNAs) play a variety of roles in cells and have thus been investigated extensively. MicroRNA-223 (miR-223) expression has been reported to be altered in post-MI heart failure in humans; however, the roles of miR-223 in MI remain unknown. Our study aimed to elucidate the roles of miR-223 in cardiac fibrosis. Methods: Cultured cardiac fibroblasts (CFs) were activ

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