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Relevant bibliographies by topics / Lafutidine

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Academic literature on the topic 'Lafutidine'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Lafutidine"

1

Damodhar, Vijay Kumar. "Formulation and Evaluation of Floating in Situ Gel of Lafutidine." International Journal of Medical, Pharmacy and Drug Research 7, no. 5 (2023): 08–14. http://dx.doi.org/10.22161/ijmpd.7.5.2.

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Gastroesophageal reflux disease (GERD) and peptic ulcers are prevalent gastrointestinal disorders that significantly impact the quality of life of affected individuals. Lafutidine, a histamine H2-receptor antagonist, has demonstrated effectiveness in managing these conditions. However, its short gastric residence time limits its therapeutic efficacy. To address this limitation, we aimed to formulate and evaluate a floating in situ gel of Lafutidine for prolonged gastric retention and enhanced therapeutic outcomes. In vivo studies were conducted on albino Wistar rats to assess the pharmacokinet

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2

Kumar, Ritesh, Amrish Chandra, Swati Gupta, and Pawan Kumar Gautam. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF LAFUTIDINE IN BULK AND PHARMACEUTICAL DOSAGE FORM." International Journal of Applied Pharmaceutics 9, no. 6 (2017): 75. http://dx.doi.org/10.22159/ijap.2017v9i6.21943.

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Objective: The objectives of the present research was to develop a simple, precise, economical, accurate, reproducible and sensitive method for the quantitative estimation of lafutidine in bulk and its pharmaceutical dosage forms by Ultra Violet (UV) absorption spectrophotometry.Methods: The method uses 0.1 N HCl, pH 1.20 as a solvent of choice for the quantitative estimation of lafutidine in bulk and its tablets dosage form by UV absorption spectrophotometry at a wavelength of 290 nm. The method was validated for parameters like linearity, range, precision, Limit of Detection (LOD), Limit of

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3

Deshmukh, Mr Vikram Tanaji, and Dr Jagdish Chandra Pati. "Development and Evaluation of In-Situ Floating Gel In treatment of Gastroesophageal Reflux Disease (Gerd)." Journal of Drug Discovery and Therapeutics 11, no. 2 (2023): 70–92. http://dx.doi.org/10.32553/jddt.v11i2.466.

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Gastroretentive drug delivery systems can deliver narrow-window drugs to the upper stomach at a controlled rate. The raft forming process is better than floating structures, liquid dosing mediums, and in situ gelation for sustained drug release in the upper GI tract. According to statistics, lafutidine is exactly put in the parietal cells of the stomach mucosa, where the upper gastro-intestinal tract absorbs it. Lafutidine capsules had 65–70% bioavailability compared to intravenous infusion. Stability and absorption are acceptable between 1 and 4. The colon and lower gastrointestinal tract deg

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4

Dewan, Bhupesh, and Nisha Philipose. "Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial." Gastroenterology Research and Practice 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/640685.

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Background. Empirical therapy with antisecretory agents like PPIs and H2RAs has long been the traditional approach in the initial management of uninvestigated dyspepsia.Aim. The objective of the study was to examine relief of dyspepsia with lafutidine, a second-generationH2-RA, and rabeprazole and to compare their efficacy.Methods. This was a randomized, open, comparative trial in adult uninvestigated dyspeptic patients, who had at least moderate severity of symptoms, defined as a score of≥4 on a 7-point global overall symptom (GOS) scale, and were randomized to receive once daily either lafut

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Deshmukh, Mr Vikram Tanaji, and Dr Jagdish Chandra Pati. "Development and Validation of RP-HPLC Method of Lafutidine (API)." Journal of Drug Discovery and Therapeutics 11, no. 2 (2023): 93–104. http://dx.doi.org/10.32553/jddt.v11i2.467.

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The goal of this study is to develop and validate an RP HPLC technique for estimating Lafutidine in bulk form. A thorough review of the literature found that there are ways available, but none of them are as straightforward, specific, exact, or accurate as the established approach for estimating Lafutidine. The chromatographic method was found to be suitable for effective separation of Lafutidine with good resolution, peak shape. The mobile phase composed of 0.1M ammonium acetate buffer (pH 7.5): Methanol (80:20 v/v), at a flow rate of 1.4 ml/min was selected as it gave well resolved peaks of

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6

Rahul, Kumar Garg, and Singhvi Indrajeet. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF LAFUTIDINE FROM TABLET FORMULATION." Pharmaceutical and Chemical Journal 1, no. 2 (2014): 1–4. https://doi.org/10.5281/zenodo.13690955.

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One simple and sensitive spectrophotometric method has been developed for the quantitative estimation of Lafutidine from tablet. The method was developed and based on the solubility of Lafutidine in 0.1 N HCl (pH 1.2). The drug showed maximum absorbance at 286 nm and linearity (Lambert Beer’s Range) was found in concentration range of 10-60 μg/ml and the standard curve equation was found to be  y = 0.015x - 0.015 and R<sup>2</sup> value 0.997. The results of analysis were validated statistically and by recovery studies. The result of analysis was validated as per ICH guidelines a

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7

Jadhav, Kiran, D. L. Dhamecha, S. V. Ghadlinge, G. P. Asnani, and M. B. Patil. "Simultaneous Estimation of Lafutidine and Domperidone by Ultraviolet Spectroscopy." ISRN Analytical Chemistry 2012 (June 21, 2012): 1–4. http://dx.doi.org/10.5402/2012/401702.

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A simple, accurate, and precise method for simultaneous estimation of Lafutidine and Domperidone in combined-dosage form have been described. The method employs formation and solving of simultaneous equations using 279 and 284 nm as two analytical wavelengths. This method allows the simultaneous determination of Lafutidine and Domperidone in concentration ranges employed for this purpose with the standard deviation of <1.0% in the assay of tablet.

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8

Sanjivani Gorakhnath Borkar, Lahu Hingane, Parvati. D. Shere, and Vilas Ingole. "Development and validation of RP-HPLC method for the simultaneous estimation of rabeprazole sodium and lafutidine in combined dosage form." World Journal of Biology Pharmacy and Health Sciences 14, no. 2 (2023): 240–50. http://dx.doi.org/10.30574/wjbphs.2023.14.2.0200.

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A simple, rapid, specific, accurate and precise RP-HPLC method was developed for the simultaneous estimation of Lafutidine and Rabeprazole Sodium in combined dosage form. A Hi Q sil C-8 Column (250 mm × 4.6 mm, 5 μm) in Isocratic mode with mobile phase containing Acetonitrile : Phosphate Buffer (70:30 v/v) pH 7.3 was used. The flow rate was 1.0ml/min and effluents were monitored at 230 nm. The retention time of Rabeprazole Sodium and Lafutidine was found to be 3.658 min and 5.408 min respectively. Validation parameters such as linearity, precision, accuracy, limit of detection(LOD), limit of q

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9

Sanjivani, Gorakhnath Borkar, Hingane Lahu, D. Shere Parvati., and Ingole Vilas. "Development and validation of RP-HPLC method for the simultaneous estimation of rabeprazole sodium and lafutidine in combined dosage form." World Journal of Biology Pharmacy and Health Sciences 14, no. 2 (2023): 240–50. https://doi.org/10.5281/zenodo.8039203.

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A simple, rapid, specific, accurate and precise RP-HPLC method was developed for the simultaneous estimation of Lafutidine and Rabeprazole Sodium in combined dosage form. A Hi Q sil C-8 Column (250 mm × 4.6 mm, 5 μm) in Isocratic mode with mobile phase containing Acetonitrile : Phosphate Buffer (70:30 v/v) pH 7.3 was used. The flow rate was 1.0ml/min and effluents were monitored at 230 nm. The retention time of Rabeprazole Sodium and Lafutidine was found to be 3.658 min and 5.408 min respectively. Validation parameters such as linearity, precision, accuracy, limit of detection(LOD), l

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10

Machida, Nozomu, Masanori Terashima, Keisei Taku, et al. "A prospective multicenter trial of S-1 with lafutidine vs S-1 as adjuvant chemotherapy for gastric cancer in Japan: AEOLUS." Journal of Clinical Oncology 36, no. 4_suppl (2018): 91. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.91.

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91 Background: From the result of ACTS-GC study, adjuvant chemotherapy with S-1 for one year is standard therapy of gastric cancer in Japan. In this study, completion rate of pre-planned S-1 treatment was 65.8% and there is still room for improvement on this rate. Lafutidine is a H2 blocker and enhances submucosal blood flow via capsaicin-sensitive afferent neurons. Alleviating effect of lafutidine on toxicity of 5FU leading to discontinuation of adjuvant treatment could be expected. Methods: Patients with histologically confirmed stage II (excluding T1 cases), IIIA, or IIIB (Japanese Classifi

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Book chapters on the topic "Lafutidine"

1

Amagase, Kikuko, and Koji Takeuchi. "Lafutidine Protects the NSAID-Induced Small Intestinal Lesions Mediated by Capsaicin-Sensitive Afferent Neurons." In Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside. InTech, 2014. http://dx.doi.org/10.5772/58604.

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