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Kartika, Tia, Prima Adelin, and Rinita Amelia. "Hubungan Kadar Laktat Dehidrogenase dengan Derajat Preeklampsia-Eklampsia di RSUP Dr.M.Djamil Padang Tahun 2017." Health & Medical Journal 1, no. 1 (July 10, 2019): 1–6. http://dx.doi.org/10.33854/heme.v1i1.212.
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Preeclampsia is the cause of maternal deaths that high after bleeding. Lactate dehydrogenase (LDH) useful as biochemical markers to describe the severity of the preeclampsia-eclampsia. Aim of this study is to find out the relationship of lactate dehydrogenase levels with preeclampsia-eclampsia degrees in RSUP DR.M.Djamil Padang 2017. Methods od this research is observational analytic uses secondary data derived by medical record. The place of study was carried out at the medical record installation of central general hospital DR.M.Djamil Padang. The time of the study wasconducted in December 2018 - January 2019. The sample is preeklampsia-eklampsia patients these being treated in installation of inpatient and installation of outpatient in central general hospital DR.M.Djamil Padang 2017 which meets the criteria of inclusion and exclusion and drawn using simple random sampling techniques amounted to 32 people.Univariate analysis is presented in the form of tables and bivariate analysis was presented in the form af a table using the Spearman test. Results : Based on the research results obtained severe preeclampsia patients 21 persons (65,6%) have average levels of lactate dehydrogenase 979,05 u/l with range 313-1755 and eclampsia patients 11 persons (34,4%) have average levels of lactate dehydogenase 1838,64 u/l with range 420-5508. Spearman correlation tst obtained significant value of 0.001 and correlation 0,545. Conclusion : There is a relationship between the levels of lactate dehydrogenase with degree preeclampsia-eclampsia (p<0,05) with medium correlation (r=0,545)
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Knechtle, Beat, and Pantelis T. Nikolaidis. "Der Einfluss eines Ultramarathons auf den Bewegungsapparat." Praxis 107, no. 7 (March 2018): 387–91. http://dx.doi.org/10.1024/1661-8157/a002927.
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Zusammenfassung. In den vergangenen Jahrzehnten hat sich die Zahl der Ultraläufer vervielfacht, und viele Studien haben den Einfluss auf den Bewegungsapparat untersucht. Wir stellen die Erkenntnisse zu Schäden zusammen, die ein Ultramarathon an Gelenken und Muskeln verursachen kann. Die häufigsten Verletzungen bzw. Überlastungsschäden betreffen die untere Extremität, wobei Sprunggelenk und Knie am häufigsten betroffen sind. Bei sehr langen Läufen kommt es zu einer Anpassung mit Verdickung von Sehnen und Knorpel. Ein Ultramarathon kann zu einem ausgeprägten Muskelschaden führen, mit einem Anstieg von myozellulären Metaboliten wie Myoglobin, Laktat-Dehydrogenase und Creatinkinase.
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Muyassaroh, Siti, and Indah Rahmatiah Siti Salami. "UJI TOKSISITAS SODIUM SIANIDA (NaCN) PADA BEBERAPA SPESIES IKAN AIR TAWAR: REVIEW (The Toxicity Test of Sodium Cyanide (NaCN) to Some Species of Freshwater Fish: A Review)." Jurnal Manusia dan Lingkungan 25, no. 1 (September 11, 2020): 1. http://dx.doi.org/10.22146/jml.23117.
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AbstrakSianida telah digunakan sebagai senyawa toksik selama beberapa dekade untuk penangkapan ikan. Pengetahuan para nelayan yang rendah dapat menyebabkan kelebihan dosis penggunaan senyawa sianida. Hal ini dapat menyebabkan kematian ikan dan bahkan kerusakan terumbu karang. Sodium sianida tidak bersifat bioakumulasi dan biomagnifikasi berdasarkan nilai Kow-nya dan sebagian besar metabolit dikeluarkan melalui urin dalam bentuk thiosianat, SCN- (60-80%), 2-aminothiazoline-4-carboxylic acid (ATCA) atau 2-iminothiazolidine-4-carboxylic acid, ITCA (15%), serta gas HCN dan CO2. Biomarker organisme yang terpapar sianida yaitu kandungan CN-, SCN-,ATCA atau ITCA pada urin dan darah; perubahan histopatologis di limpa, hepato-renal dan ginjal; penurunan aktivitas enzim katalase pada jaringan hati, insang, otak, dan otot ikan; perubahan aktivitas laktat dehydrogenase (LDH) dan suksinat dehydrogenase (SDH), tingkah laku, laju respirasi, dan metabolit (asam piruvat dan asam laktat). Akan tetapi, aktivitas enzim dan struktur histopatologis kembali normal setelah pemulihan selama 14 hari di medium bebas NaCN. Paparan NaCN juga dapat menyebabkan perubahan kecepatan renang dan durasi surfacing behavior. Konsentrasi sianida di lingkungan tidak bisa diabaikan, sebab dimungkinkan adanya efek sinergis dan juga penghambatan sistem enzim katalase, yang pada akhirnya terjadi kerentanan organisme akuatik terhadap toksisitas sianida. Labeo rohita merupakan spesies ikan air tawar yang paling sensitif terhadap paparan NaCN, dengan nilai LC50 sebesar 0,32 mg/L (tanpa melihat jenis aliran yang digunakan).AbstractCyanide has been used as a toxic compound for decades for fishing. Lack of knowledge of fishermen can lead to overdosing use of a compound. This can lead to fish kills and even damage the coral reefs. Sodium cyanide is not bioaccumulative and biomagnificative based on the value of Kow and most metabolites are excreted in the urine in the form of SCN- (60-80%), 2-aminothiazoline-4-carboxylic acid, ATCA or 2-iminothiazolidine-4-carboxylic acid, ITCA (15%), as well as HCN gas and CO2. Biomarkers organisms are exposed cyanide content of CN-, SCN-, ATCA or ITCA on urine and blood; histopathological changes in spleen, hepato-renal and kidney; decreased activity of catalase enzyme in the liver, gills, brain, and muscles of fish; lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) activity changes, behavioral, respiratory rate, and metabolites (pyruvic acid and lactic acid). However, the enzyme activity and histopathological structure back to normal after recovery for 14 days at NaCN-free medium. NaCN exposure can also cause changes in swimming speed and duration of surfacing behavior. The concentration of cyanide in the environment can not be ignored, because it is possible the existence of a synergistic effect and also the inhibition of catalase enzyme system, which eventually happened vulnerability of aquatic organisms to cyanide toxicity. Labeo rohita is a freshwater fish species are most sensitive to exposure to NaCN, with LC50 values of 0.32 mg / L (regardless of the type of flow used).
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Kohnert, K., H. Lerch, M. Thelen, and O. Schober. "Verlaufskontrolle des Neuroblastoms Stadium IV: 123I-mIB G- Szintigraphie, Knochenszintigraphie und Katecholaminmetabolite." Nuklearmedizin 35, no. 06 (1996): 220–24. http://dx.doi.org/10.1055/s-0038-1629779.
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Zusammenfassung Ziel: Es soll die Wertigkeit von 123l-mlBG-Szintigraphie, Knochenszintigraphie und Katecholaminmetaboliten bei der Verlaufskontrolle untersucht werden. Methode: Es wurden 19 Kinder mit Neuroblastom im Stadium IV retrospektiv mit 123l-mlBG- und 99mTc-MDP-Szintigraphie untersucht und deren Ergebnisse mit der Bestimmung von Homovanillinsäure, Vanillinmandelsäure, neuronenspezifische Enolase, Laktat-dehydrogenase und Ferritin über einen Beobachtungszeitraum von 7-132 (Median: 36) Monaten verglichen. Ergebnisse und Schlußfolgerung: Die Ergebnisse zeigen, daß die Wertigkeit der einzelnen Verfahren vom Zeitpunkt des diagnostischen Einsatzes abhängig ist. Prinzipiell ist die mlBG-Szintigraphie das Verfahren mit der höchsten diagnostischen Aussagekraft. Zum prätherapeutischen Staging und zur Diagnostik des Rezidivs ist die Kombination aller drei Methoden sinnvoll. Bei der Verlaufskontrolle unter Chemotherapie spiegelt die mlBG-Szintigraphie die Heterogenität des Therapieeffektes am besten wider. Die Laborparameter eignen sich zum Therapiemonitoring wenig; der diagnostische Zugewinn durch die Skelettszintigraphie ist umstritten.
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Karpovskyi, V. І., and O. M. Bobritska. "The influence of electromagnetic radiation of “PARKES-L” device on metabolism in puppies." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 88 (October 21, 2018): 11–15. http://dx.doi.org/10.32718/nvlvet8802.
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Ten puppies of the German shepherd breed at the age of up to 60 days were divided into two groups – control and experimental. The influence of low-frequency electromagnetic radiation of “PARKES-L” device on the indexes of exchange of proteins, fats, carbohydrates and activity of key enzymes of carbohydrate and protein exchange: aspartat-aminotransferase, alanine-aminotransferase and laktat dehydrogenase were determined. The “PARKES-L” device which has the range of working frequencies from 0,1 hertz to 30 kHz, the action of device is based on the reflex mechanism of action of weak low-frequency electromagnetic impulses on the receptors of skin (biologically active areas) of animals. The effect of device is obtained due to radiation of electromagnetic impulses by infrared light-emitting diodes, which are at the back and front sides of the device. It was determined that under the influence of electromagnetic radiation the processes of intermediate exchange of organic compounds are not changed, but anabolic processes in tissues increase which are in the process of growth and development of puppies. Therefore, till the end of the experiment it was determined that living mass of puppies of experimental group exceeded control group by 580 grams. We also proved that under the influence of electromagnetic radiations the use of nitrogen contained metabolites increased, taking into account the increase of whole protein concentration and protein fractions. Energy exchange also gets better due to the increase of aerobic oxidation that is confirmed by the increase of oxidizing phosphorylating reaction and reliable increase of kreatinin concentration. The increase of lipid fractions (triglycerides and phosphatides) and concentration of lipid fractions also confirm the strengthening of anabolic processes in tissues. It was determined by the research the increase of free amino acid in blood of puppies of experimental group on the background of diminishing of nitrogen ammonia level that is related to the increase of biosynthesis of amino acid in tissues by the mechanism of amination of keto-acids due to better use of non-protein nitrogen. Under the influence of “PARKES-L” radiation the activity of aminotransferase (aspart-aminotransferase, alanine-aminotransferase and laktat-dehydrogenase) increased for certain (Р ˂ 0.001) that testifies the increase of exchange of proteins and carbohydrates level. It is determined in our research that the influence of low-frequency electromagnetic radiation stimulates the growth and development of puppies of the German shepherd breed. Functional activity of the systems of haemopoiesis, digestion and processes of biosynthesis of proteins, fats and carbohydrates and also activity of key enzymes of protein and carbohydrate exchanges increased under the influence of “PARKES-L” device.
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Rosef, Olav, Håvard L. Nystøyl, Tore Solenes, and Jon M. Arnemo. "Haematological and serum biochemical reference values in free-ranging red deer (Cervus elaphus atlanticus)." Rangifer 24, no. 2 (April 1, 2004): 79–85. http://dx.doi.org/10.7557/2.24.2.304.
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Analyses of haematological and biochemical constituents were carried out on the Norwegian subspecies of free-ranging red deer (Cervus elaphus atlanticus). All animals were captured from January to March by using a mixture of xylazine and tiletamin-zolazepam. Immobilisation was performed with plastic projectile syringes fired from a dart gun. Fourteen haematological parameters were analysed. There were no differences in the values between hinds and stags and between adults and calves (P > 0.01). Of the 22 biochemical compounds investigated there was a significant difference (P < 0.01) between calves and adults for lactate dehydrogenase (LD), globulin, beta globulin, gamma globulin, and the minerals Na, K, Mg, Zn, Ca, and P. Differences (P < 0.01) between hinds and stags were found in cholesterol, gamma glutamyl transferase (GGT), alpha-1 globulin, alpha-2 globulin and Cu. The blood values determined in this study can be used as reference values for this red deer subspecies immobilised with a mixture of xylazine-tiletamin-zolazepam for health control and diagnosis of diseases.Abstract in Norwegian /Sammendrag:Hematologiske og biokjemiske parametere er analysert på norsk frittlevende hjort (Cervus elaphus atlanticus). Hjorten ble immobilisert i tidsrommet januar til mars ved hjelp av et spesialgevær ladet med plast kanyler som inneholdt en blanding av xylazin og tiletamin-zolazepam. Det var ingen forskjeller i de14 undersøkte hematologiske verdiene mellom hinder, kalver og bukker (P>0,01). Av de 22 biokjemiske parametrene som ble undersøkt var det en signifikant forskjell mellom kalver og voksne (P<0,01) når det gjelder laktat dehydrogenase, globulin, beta globulin, gamma globulin og mineralene Na, K, Mg, Zn, Ca og P. Det var en signifikant forskjell mellom hinder og bukker (P<0.01) på parametrene kolesterol, gamma glutamyl transferase, alfa-1 globulin, alfa-2 globulin og Cu. Blodverdiene som ble målt i dette studiet kan bli brukt som referanseverdier for norsk hjort som er immobilisert med blandingen xylazin-tiletamin-zolazepam for helsekontroll og for diagnostisering av sykdommer.
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Sari, Ayu Nirmala, Januardi Januardi, and Diky Setya Diningrat. "Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent." Elkawnie 6, no. 1 (June 30, 2020): 37. http://dx.doi.org/10.22373/ekw.v6i1.5496.
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Abstract : This study was designed to evaluate the anti-diabetic activity of the ethanol extract of Syzygium cumini leaves in alloxan-induced diabetes mice. The anti-diabetic activity of EDS was investigated in mice (Mus musculus SW.) Alloxan-induced diabetes. The effect of ethanol extract of Syzygium cumini leaves on normal blood glucose levels and oral glucose tolerance tests were studied in normoglycemic mice while the anti-diabetic effect was evaluated in alloxan-induced hyperglycemic mice. Ethanol extract of Syzygium cumini leaves (200 and 400 mg/kg) is given orally for 21 days. Glibenclamide (5 mg/kg, oral for 21 days) is used as a reference standard. Giving ethanol extract of Syzygium leaves causes a significant decrease in blood glucose levels in normoglycemic and hyperglycemic mice and also increases glucose tolerance test. Ethanol extract of Syzygium leaves reduces glycosylated hemoglobin levels, lactate dehydrogenase, and creatinine kinase in alloxan-treated mice. Ethanol extract of Syzygium leaves also improves TBARS oxidative stress parameters, catalase and superoxide dismutase activity and glutathione levels. The ethanol extract of Syzygium cumini leaves shows anti-diabetic activity through increased insulin secretion and this effect can be attributed to the content of flavonoids and phenolic compounds present in the ethanol extract of Syzygium cumini leaves.Abstrak : Penelitian ini dirancang untuk mengevaluasi aktivitas anti-diabetes dari ekstrak etanol daun Syzygium cumini (L) Skeels (EDS) pada mencit diabetes yang diinduksi aloksan. Aktivitas anti-diabetes EDS diselidiki pada mencit (Mus musculus SW.) diabetes yang diinduksi aloksan. Pengaruh ekstrak etanol daun Syzygium cumini (EDS) pada kadar glukosa darah normal dan uji toleransi glukosa oral dipelajari pada mencit normoglikemik sedangkan efek antidiabetik dievaluasi pada mencit hiperglikemik yang diinduksi aloksan. EDS (200 dan 400 mg/kg) diberikan secara oral selama 21 hari. Glibenclamide (5mg/kg, oral selama 21 hari) digunakan sebagai standar referensi. Pemberian EDS menyebabkan penurunan signifikan dalam kadar glukosa darah pada mencit normoglikemik dan hiperglikemik dan juga meningkatkan uji toleransi glukosa. EDS mengurangi kadar hemoglobin glikosilasi, laktat dehidrogenase, dan kreatinin kinase pada mencit yang diberi aloksan. EDS juga memperbaiki parameter stres oksidatif TBARS, aktivitas katalase dan superoksida dismutase dan kadar glutathione. Ekstrak etanol daun Syzygium cumini (EDS) menunjukkan aktivitas antidiabetik melalui peningkatan sekresi insulin dan efek ini dapat dikaitkan dengan kandungan flavonoid dan senyawa fenolik yang ada dalam ekstrak daun.
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Hamidah, Hamidah, Muh Darwin Prenggono, and Farida Heriyani. "Perbedaan Kadar LDH Serum Total Sebelum dan Sesudah Kemoterapi pada Berbagai Kelompok Stadium Kanker LNH." Berkala Kedokteran 12, no. 1 (May 2, 2016): 49. http://dx.doi.org/10.20527/jbk.v12i1.356.
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Abstract: Lactate dehydrogenase (LDH) is tumor prognostic for Non Hodgkin Lymphoma (NHL) and it levels would be elevated. The several papers has reported there are an association of total serum LDH levels and staging group of NHL. The study aimed to determine the differences of total serum LDH levels before and after the combination chemotherapy CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) for NHL’s patients at RSUD Ulin Banjarmasin during 3 years. It was an observational analyticstudy design and cross-sectional approach, data collected with design method of totally sampling. Of the 51 patient medical records who included, 54,9% were staging group I-II and 45,1% were staging group III-IV. The first statistic analytic used dependent T test with p=0,303 (p>0,05)showed no differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging group I-II. The second statistic analytic used alternative wilcoxon test with p=0,013 (p<0,05) showed differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging groupIII-IV. The third statistic analytic used alternative mann whitney test with p=0,161 (p>0,05) showed no differencesof total serum LDH levels after the combination chemotherapy CHOP in NHL’s patients between staging group I-II and III-IV.Keywords: total serum LDH levels, NHL, combination chemotherapy CHOP Abstrak: Laktat dehidrogenase (LDH) adalah tumor prognostic pada kanker Limfoma Non Hodgkin (LNH) dan kadarnya selalu menunjukan peningkatan. Penelitian sebelumnya melaporkan bahwa terdapat hubungan antara kadar LDH serum total dengan kelompok stadium kanker LNH. Penelitian ini bertujuan untuk mengetahui perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP (Siklofosfamid, Doksorubisin, Vinkristin, dan Prednison) pada penderita kanker LNH di RSUD Ulin Banjarmasin selama 3 tahun.Penelitian ini menggunakan rancangan studi observasional analitik dan metode pendekatan cross sectional, pengambilan sampel dengan teknik rancangan totally sampling. Dari 51 data rekam medik yang termasuk kriteria inklusi, 54,9% kelompok stadium I-II dan 45,1% kelompok stadium III-IV. Analisis statistik pertama menggunakan uji T berpasangandengan p=0,303 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium I-II. Analisis statistik kedua menggunakan uji alternatif yaitu uji wilcoxondengan p=0,013 (p<0,05) sehingga terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium III-IV. Analisis statistik ketiga menggunakan uji alternatif yaitu uji mann whitney dengan p=0,161 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH antara kelompok stadium I-II dan III-IV. Kata-kata kunci: kadar LDH serum total, LNH, kemoterapi kombinasi CHOP
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Md. Illias, Rosli, Graeme A. Reid, and Nadzarah A. Wahab. "Comparison of the Amino Acid Sequence of L–Mandelate Dehydrogenase From Rhodotorula Graminis With Other L–2–Hydroxyacid Dehydrogenase Enzyme and its Primary Structure Prediction." Jurnal Teknologi, January 20, 2012. http://dx.doi.org/10.11113/jt.v34.638.
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Perbandingan struktur primer L(+)–mendalate dehydrogenase (L–MDH) daripada yis Rhodotorula graminis dengan protein lain di dalam bank data protein menunjukkan persamaan di antara protein ini dengan kumpulan enzim L–2–hidroksiasid dehidrogenase. LMDH daripada R. graminis mempamerkan kesamaan antara 26–42% kepada L–lactate dehidrogenase daripada Sacchomoryces cerevisiae, L–lactate dehidrogenase daripada Hansenula anomala, glikolat oksida daripada bayam, L–laktat dehidrogenase daripada Escherichia coli, LMDH daripada Psedomonas putida dan laktat–2 monooksigenase daripada Mycobakterium smegmatis. Asid amino yang penting secara strukturnya bagi LMDH diramalkan secara perbandingan dengan bahagian penting domain sitokram dan domain perlekatan FMN yang diperoleh daripada struktur tiga dimensi L–laktat dehidrogenase daripada Sacchoromyces cerevisiae. Kata kunci: L-MDH; Rhodotorula gramisis; L(+)-mandalate dehydrogenase; asid amino,flavocytochrome b2 A comparison of the primary structure or L–mandelate dehydrogenase (L–MDH) from Rhodotorula graminis with other proteins from the protein databank suggests that there is similarity between this protein and L–2–hydroxyacid dehydrogenase enzymes. R graminis LMDH exhibits 26–42% identity to L–lactate dehydrogenase from Saccharomyces cerevisiae, L–lactate dehydrogenase from Hansenula anomala, glycolate oxidase from spinach, L–lactate dehydrogenase from Escherichia coli, L–mandelate dehydrogenase from Pseudomonas putida and lactate–2–monooxygenase from Mycobacterium smegmatis. Structurally conserved amino acids are predicted from LMDH sequences corresponding to important regions of the cytochrome and FMN–binding domain defined from the known three–dimensional structure of the L–lactate dehyrogenase from Sacchoromyces cerevisiae. Key words: L-MDH; Rhodotorula graminis; L-mandelate dehydrogenase; amino acid;flavocytochrome b2
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Kasir, Dian Rahma, Irza Wahid, and Hafni Bachtiar. "Hubungan Kadar Laktat Dehidrogenase dengan Stadium Limfoma Maligna Non Hodgkin di Rumah Sakit Dr. M. Djamil Padang periode Desember 2009 sampai Maret 2013." Jurnal Kesehatan Andalas 3, no. 2 (May 1, 2014). http://dx.doi.org/10.25077/jka.v3i2.46.
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AbstrakAwal abad ke-2l masyarakat Indonesia mengalami transisi epidemiologi penyakit. Perubahan pola penyakit ini dapat dilihat dari peningkatan insiden penyakit kanker sebagai penyebab kematian di Indonesia dalam 10 tahun terakhir, yaitu dari urutan ke-12 menjadi urutan ke-6. Di Indonesia, limfoma non Hodgkin (LNH) menduduki urutan keenam keganansan yang sering terjadi. Berdasarkan penelitian yang dilakukan oleh Olivia Putri Perdana di bagian patologi anatomi Fakultas Kedokteran Universitas Andalas didapatkan data bahwa pada januari 1997-desember 2001 terdapat 70 (81,39%) penderita limfoma maligna non Hodgkin dari keseluruhan penderita limfoma maligna. Penelitian ini bertujuan untuk mengetahui hubungan kadar laktat dehidrogenase (LDH) dengan stadium pada penderita limfoma maligna non Hodgkin. Penelitian ini adalah penelitian analitik dengan pendekatan cross sectional dengan menggunakan data yang bersumber dari rekam medik pasien. Populasi dari penelitian ini adalah data rekam medik seluruh penderita limfoma maligna non hodgkin yang berobat ke RSUP Dr. M. Djamil Padang yaitu 317 data rekam medik, tetapi yang memenuhi syarat untuk menjadi sampel hanya 40 data. Analisis statistik yang digunakan adalah uji T. Hasil uji statistik menunjukkan adanya hubungan kadar laktat dehidrogenase dengan stadium pada penderita limfoma non Hodgkin (P = 0,001). Diketahui nilai laktat dehidrogenase pada stadium III-IV lebih tinggi daripada nilai laktat dehidrogenase pada stadium I-II.Kata kunci: Laktat dehidrogenase, Limfoma maligna non Hodgkin, Stadium AbstractEarly 21th century, Indonesian society in transition epidemiology of the disease. Changing patterns of disease can be seen from the increased incidence of cancer as a cause of death in Indonesia in the last 10 years, ie from 12th to 6th order. In Indonesia, non-Hodgkin's lymphoma (NHL) ranks sixt frequent in all of cancer. Based on research conducted by Olivia Putri Perdana in anatomic pathology at the Faculty of Medicine, University of Andalas that the data obtained during the January 1997 - December 2001 there were 70 (81.39%) patients with non -Hodgkin's malignant lymphoma of the overall malignant lymphoma patients.This study aims to determine the relationship of levels of lactate dehydrogenase (LDH) with stage of non -Hodgkin's malignant lymphoma patients.This research is a cross sectional analytic approach using data derived from patient medical records. The population is the entire medical record malignant non Hodgkin lymphoma patients who went to DR. M. Djamil Padang hospital, they are 317 medical records, but are eligible to be sampled only 40 data. Statistical analysis used is the T test.Statistical test results show that there is relationship between lactate dehydrogenase levels with stage in non -Hodgkin's lymphoma patients (P = 0.001). Known value of lactate dehydrogenase in stage III - IV is higher than the value of lactate dehidrodenase in stage I - II.Keywords: Lactate dehydrogenase, malignant non-Hodgkin's lymphoma, Stage
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Alanlı, Recep, Murat Bülent Küçükay, and Kadir Serkan Yalçın. "Effectiveness of lactate dehydrogenase to albumin ratio in diagnosis of pulmonary thromboembolism." Medical Journal of Bakırkoy, 2021. http://dx.doi.org/10.5222/bmj.2021.81905.
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Background: The aim of the study is to inspect effectiveness of lactate dehydrogenase (LDH) to albumin ratio (LAR) in patients with pulmonary thromboembolism (PTE). Methods: In this single center and retrospective study, 307 patients who admitted to emergency unit, between January 2017 and March 2020, with chest pain and sudden developing dyspnea were enrolled. Computed tomography pulmonary angiogram (CTPA) were performed to confirm pulmonary embolism. Results: LAR, neutrophil, monocyte, d-dimer, LDH values were significantly higher and albumin values were significantly lower in patients with pulmonary embolism compared to patients without pulmonary embolism. Average age of 307 participants were 68.93; 140 patients were confirmed for PTE and 167 were normal. Linear regression analysis for LAR in diagnosis of PTE, revealed a correlation coefficient as r=0.320 (p<0.001). Positive and negative predictive values for LAR in diagnosisi of PTE were, 63.3% and 75.2%, respectively. In ROC analysis relation of LAR to PTE was found to be stronger than LDH and albumin tests alone. Conclusion: LAR, which is a very simple and available test, may be used as a novel parameter in diagnosis of PTE.
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Weiß, T., J. Kollmeier, T. Blum, C. Boch, C. Crolow, D. Misch, S. Thiel, H. Rüssmann, and TT Bauer. "Laktat-Dehydrogenase, C-reaktives Protein und Leukozytenzahl sind prognostische Parameter bei Patienten mit Kleinzelligem Lungenkarzinom (SCLC) im Stadium IIIa-IV." Pneumologie 68, S 01 (February 24, 2014). http://dx.doi.org/10.1055/s-0034-1367983.
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Fazal, Rimsha Saleem, Swetha Chandru, and Monalisa Biswas. "Evaluation of total LDH and its isoenzymes as markers in preeclampsia." Journal of Medical Biochemistry, November 21, 2019. http://dx.doi.org/10.2478/jomb-2019-0045.
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Summary Background Preeclampsia, a rapidly progressing pregnancy-specific multi-systemic syndrome is globally the leading cause of maternal and neonatal morbidity and mortality. This study aims to evaluate the serum total Lactate dehydrogenase levels in women with preeclampsia when compared to normotensive pregnant women and assess the electrophoretic pattern of the LDH isoenzymes in normal pregnancy, preeclampsia and eclampsia. Methods The study, carried out in the Department of Biochemistry of MVJ Medical College, included 30 patients of preeclampsia and 30 normotensive gestational age-matched pregnant women admitted to the Department of OBG. Serum total LDH was analysed by DGKC method. Serum and cord blood samples for isoenzyme distribution analysis were collected from a normal pregnant woman undergoing delivery, a woman with mild eclampsia, two women with eclampsia, and analysed by slab gel electrophoresis followed by activity staining. Results LDH was significantly elevated in cases as well as between the case (mild and severe) groups, showed a moderate positive statistically significant correlation with systolic, diastolic blood pressure and a sensitivity of 50% and a specificity of 80%. Further, the isoenzyme pattern showed a decreasing distribution of aerobic forms of LDH in preeclampsia-eclampsia. Conclusions Preeklampsija, multisistemski sindrom koji brzo napreduje zbog trudnoće, vodeći je uzrok morbiditeta i mortaliteta majki i novoro|enčadi. Ova studija ima za cilj da proceni nivo ukupne laktat dehidrogenaze u serumu kod žena sa preeklampsijom u poređenju sa normotenzivnim trudnicama i proceni elektroforetski obrazac LDH izoenzima u normalnoj trudnoći, preeklampsiji i eklampsiji.
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Wang, Danchen, Chaochao Ma, Yutong Zou, Songlin Yu, Honglei Li, Xinqi Cheng, Ling Qiu, and Tengda Xu. "Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data." Journal of Medical Biochemistry, November 21, 2019. http://dx.doi.org/10.2478/jomb-2019-0046.
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Summary Background Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish age- and gender-specific RIs for common biochemical analytes by laboratory data mining. Methods In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Common biochemical analytes [total protein, albumin, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), potassium, sodium, chlorine, calcium, urea, glucose, uric acid (UA), inorganic phosphorus, creatinine (Cr), total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol] were measured using an automatic analyzer. Sources of variation were identified by multiple regression analysis. The 2.5th and 97.5th percentiles were calculated as the lower and upper limits of the RIs, respectively. Results Metode indirektnog uzorkovanja nisu samo jeftine, već su i efikasne za uspostavljanje referentnih intervala (RI) korišćenjem velike količine kliničkih podataka. Ova studija je sprovedena sa ciljem da se odaberu potpuno normalni pojedinačni zapisi da bi se utvrdio RI za starost i pol za zajedničke biohemijske analite pomoću laboratorijski dobijenih podataka. Conclusions Ukupno je uzeto 280.206 pojedinačnih rezultata u periodu od 2014. do 2018. godine iz bolnice Peking Union Medical College-a. Uobičajeni biohemijski analiti [ukupni protein, albumin, ukupni bilirubin (TBil), direktni bilirubin (DBil), alanin aminotransferaza (ALT), glutamiltranspeptidaza (GGT), alkalna fosfataza (ALP), aspartat aminotransferaza (AST), laktat dehidrogenaza (LAT) kalijum, natrijum, hlor, kalcijum, ureja, glukoza, mokraćna kiselina (UA), neorganski fosfor, kreatinin (Cr), ukupni hole sterol, trigliceridi, lipoprotein holesterola visoke gustine i lipoprotein holesterola niske gustine] mereni su korišćenjem automatskog analizatora. Izvori varijacije identifikovani su višestrukom regresionom analizom. Postoci (2,5 i 97,5) su izračunati kao donja i gornja granica RI, svaki ponaosob.
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BELGE KURUTAŞ, Ergül, and Sermin GÜL. "Farelerde Oksidatif Stres Biyobelirteçlerinin ve Laktik Dehidrogenazin Biyolojik Varyasyonu." Kafkas Universitesi Veteriner Fakultesi Dergisi, 2015. http://dx.doi.org/10.9775/kvfd.2014.11891.
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