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Journal articles on the topic 'Lambaréné (Gabon)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 June 2024

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1

J. D., Maloba Makanga, and Mbadinga Igaly E. "Hydro-Climatic Variability of the Ogooue Watershed in Lambaréné." Modern Environmental Science and Engineering 8, no. 5 (May 22, 2022): 310–17. http://dx.doi.org/10.15341/mese(2333-2581)/05.08.2022/009.

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Located in the center-west of Gabon, the city of Lambaréné is frequently affected by floods which cause material, economic and health damage. This scientific contribution presents the preliminary results of a larger study on the risks of flooding in the Ogooué basin in Lambaréné. The analysis of the flows (1959-1989), water levels (2000-2010) and rainfall common to both time periods shows that the most favorable period for floods corresponds, among others, to the months of October and November that record abundant precipitation, at the origin of the main hydrological peaks of November-December. In general, there is an evolution in phase between the pluviometric positive anomalies, flows and water heights likely to cause overflows of the waters of the Ogooué. Key words: Gabon, rainfall, water level, variability

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Okuda, K. V., N. Toepfner, A. S. Alabi, B. Arnold, S. Bélard, U. Falke, L. Menschner, S. Monecke, A. Ruppelt-Lorz, and R. Berner. "Molecular epidemiology of Staphylococcus aureus from Lambaréné, Gabon." European Journal of Clinical Microbiology & Infectious Diseases 35, no. 12 (August 23, 2016): 1963–73. http://dx.doi.org/10.1007/s10096-016-2748-z.

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Adegnika, Ayôla A., Michael Ramharter, Selidji T. Agnandji, Ulysse Ateba Ngoa, Saadou Issifou, Maria Yazdanbahksh, and Peter G. Kremsner. "Epidemiology of parasitic co-infections during pregnancy in Lambaréné, Gabon." Tropical Medicine & International Health 15, no. 10 (July 15, 2010): 1204–9. http://dx.doi.org/10.1111/j.1365-3156.2010.02598.x.

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4

Flamen, A., S. Bélard, C. Kokou, S. Janssen, and M. P. Grobusch. "Childhood tuberculosis in Lambaréné, Gabon: tuberculosis control in its infancy?" Infection 42, no. 1 (September 14, 2013): 161–64. http://dx.doi.org/10.1007/s15010-013-0529-5.

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Medjo Mvé, Pither, and Mexcent Zuè Elibiyo. "enquête sociolinguistique sur la transmission intergénérationnelle des langues au Gabon." Travaux neuchâtelois de linguistique, no. 52 (January 1, 2010): 51–68. http://dx.doi.org/10.26034/tranel.2010.2833.

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In this contribution, we examine the question of the transmission of Bantu languages from the generation of the parents to the generation of children, into the specific context of Gabon. Our results are based upon a sociolinguistic survey (Zuè Elibiyo, 2008) made in two different cities of Gabon. One of these cities is located in the north-west (Libreville), and the other one in the center (Lambaréné). The data analysis shows that French language is clearly the language which the great majority of the parents transmit to their children. Nevertheless, at least two Bantu local languages, Fang (A75) and Gisir (B41) are, to a certain extent, also spoken by adults to the children within the family context. Finally, we show that not all local languages of Gabon are really endangered, even though their transmission is globally in decline.

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Lim, Jacqueline Kyungah, José Francisco Fernandes, In-Kyu Yoon, Jung-Seok Lee, Regis Obiang Mba, Kang Sung Lee, Suk Namkung, et al. "Epidemiology of dengue fever in Gabon: Results from a health facility-based fever surveillance in Lambaréné and its surroundings." PLOS Neglected Tropical Diseases 15, no. 2 (February 10, 2021): e0008861. http://dx.doi.org/10.1371/journal.pntd.0008861.

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Background In Africa, information on dengue is limited to outbreak reports and focused on some countries with continuing transmission in West and East Africa. To estimate the proportion of dengue-positive cases among febrile patients and identify clinical indicators of dengue cases, we conducted passive facility-based fever surveillance in a catchment area population of 70,000 residents of Lambaréné and its surroundings in Gabon. Methods Non-malarial febrile patients with current fever or history of fever (≤7 days) between 1 and 55 years of age, were enrolled at Albert Schweitzer Hospital (ASH). Acute (visit 1, day of enrollment) and convalescent blood samples were collected between 10 and 21 days after enrollment. Acute/convalescent samples were tested with IgM/IgG ELISA, and a selected subset of acute samples with RT-PCR. Results Among 682 non-malarial febrile patients enrolled, 119 (17.4%) were identified as dengue-positive (94 dengue-confirmed and 25 dengue-probable cases). Of these dengue-positive cases, 14 were confirmed with PCR, and based on serotyping, two infections were identified to be DENV-2 and two were DENV-3. The majority of our enrolled patients were <25 years of age and close to 80% of our dengue-positive cases were <15 years of age. In adjusted analyses, retro-orbital pain and abdominal pain were 2.7 and 1.6 times more frequently found among dengue-positive cases, compared to non-dengue cases. Conclusion Lambaréné is not considered dengue-endemic. However, one in six non-malarial febrile episodes was found to be dengue-positive in the study period. Dengue should be considered more frequently in clinicians’ diagnosis among non-malarial febrile patients in Lambaréné. Given the lack of data on dengue in Gabon, additional prospective and longitudinal studies would help to further define the burden and patterns of dengue for improved case detection.

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Dejon-Agobé, Jean Claude, Ayôla A. Adegnika, and Martin P. Grobusch. "Haematological changes in Schistosoma haematobium infections in school children in Gabon." Infection 49, no. 4 (January 24, 2021): 645–51. http://dx.doi.org/10.1007/s15010-020-01575-5.

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Abstract Background Schistosomiasis is a parasitic disease affecting the blood cell. As a chronic disease, schistosomiasis particularly impacts on the human host’s haematological profile. We assessed here the impact of urogenital schistosomiasis on the full blood counts (FBC) as proxy diagnostic tool for schistosomiasis. Methods A cross-sectional study was conducted among school children living in Lambaréné, Gabon. Schistosomiasis status was determined using urine filtration technique. EDTA blood samples were analysed using a Pentra ABX 60® analyzer. Results Compared to their infection-free counterparts, school children infected with Schistosoma haematobium displayed an altered FBC profile, with changes in all three blood cell lines. Adjusted for praziquantel intake, soil-transmitted helminthic infections and Plasmodium falciparum infection status, schistosomiasis was independently associated with a decreasing trend of mean haemoglobin (β = − 0.20 g/dL, p-value = 0.08) and hematocrit (β = − 0.61%, p-value = 0.06) levels, a lower mean MCV (β = − 1.50µm3, p-value = 0.02) and MCH (β = − 0.54 pg, p-value = 0.04), and higher platelet (β = 28.2 103/mm3, p-value = 0.002) and leukocyte (β = 1.13 103/mm3, p-value = 0.0003) counts, respectively. Conclusions Schistosomiasis is associated with a characteristic FBC profile of schoolchildren living in Lambaréné, indicating the necessity to consider schistosomiasis as a single cause of disease, or a co-morbidity, when interpreting FBC in endemic areas.

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Epola Dibamba Ndanga, Micheska, Jabar Babatundé Pacome Achimi Agbo Abdul, Jean Ronald Edoa, Rhett Chester Mevyann, Bayodé Romeo Adegbite, Arnault Mfoumbi, Christopher Mebiame Biyogho, et al. "Non‐tuberculous mycobacteria isolation from presumptive tuberculosis patients in Lambaréné, Gabon." Tropical Medicine & International Health 27, no. 4 (February 27, 2022): 438–44. http://dx.doi.org/10.1111/tmi.13736.

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Agobé, Jean Claude Dejon, Frejus Jeannot Zinsou, J. Honkpehedji, Ulysse Ateba Ngoa, Peter Kremsner, and Ayola Adegnika. "EFFECT OF SCHISTOSOMA HAEMATOBIUM INFECTION ONPLASMODIUM FALCIPARUMMALARIA BURDEN IN LAMBARÉNÉ, GABON." BMJ Global Health 2, Suppl 2 (February 2017): A59.2—A59. http://dx.doi.org/10.1136/bmjgh-2016-000260.158.

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GRAY, CHRISTOPHER, and FRANÇOIS NGOLET. "LAMBARÉNÉ, OKOUMÉ AND THE TRANSFORMATION OF LABOR ALONG THE MIDDLE OGOOUÉ (GABON), 1870–1945." Journal of African History 40, no. 1 (March 1999): 87–107. http://dx.doi.org/10.1017/s0021853798007361.

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IN 1929, the French colonial administration's forced recruitment of labor for two road construction projects designed to create more effective transportation links between the town of Lambaréné on the Middle Ogooué and the colonial post at Mouila on the Upper Ngounié led to food shortages in several parts of southern Gabon. A disturbing pattern had developed over the previous 15 years where colonial demands for labor led to disruptions in the seasonal cycle of agricultural production. Able-bodied men forced to gather forest products or work as porters to pay the head tax, or required to participate in the construction of colonial infrastructure projects, or even willingly employed as laborers in the growing timber industry, could not meet their traditional obligations to clear fields for women farmers during the long dry season (generally June to September), thus leading to poor harvests and food shortages. French officials at the end of the 1920s were especially anxious as the Fang populations in the northern portion of the colony had experienced severe famine several years earlier, partly due to male workers being recruited into the timber industry. Memories of famine occurring between 1916 and 1918 were also quite vivid among the peoples living along the Ngounié. Labor recruitment for the timber industry and colonial infrastructure projects remained a precarious enterprise at the outset of the 1930s. Yet by the 1940s, the most difficult segment of the Lambaréné–Mouila road network – a 50 kilometer stretch through hilly, forested terrain south of Lambaréné – was completed without resorting to forced labor and without the threat of food shortages. The intervening decade had witnessed the final stage of the transformation of Gabonese labor wrought by the French colonial presence, a transformation that broke the pre-colonial system of labor exploitation controlled by clan leaders. At the outbreak of World War II, the process had advanced to the point that there now existed a ‘labor market’ in the French Equatorial Africa federation integrated into the capitalist wage-earning sector and capable of accomplishing infrastructure projects without disastrous consequences for the local population. We argue that the predominance of the timber industry in Gabon placed these developments on a strangely ambiguous path when compared to the growth of capitalist wage-labor in other parts of the continent.

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Honkpéhèdji, Yabo Josiane, Bayode Romeo Adegbite, Jeannot Fréjus Zinsou, Jean Claude Dejon‐Agobé, Jean‐Ronald Edoa, Rella Zoleko Manego, Matthew McCall, et al. "Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon." Tropical Medicine & International Health 26, no. 8 (May 4, 2021): 973–81. http://dx.doi.org/10.1111/tmi.13591.

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Bélard, Sabine, Stefan Niemann, Sanne Bootsma, Afsatou N. Traoré, Régis M. Obiang Mba, Kara K. Osbak, Martin P. Grobusch, et al. "Tuberculosis Treatment Outcome and Drug Resistance in Lambaréné, Gabon: A Prospective Cohort Study." American Journal of Tropical Medicine and Hygiene 95, no. 2 (August 3, 2016): 472–80. http://dx.doi.org/10.4269/ajtmh.15-0668.

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Visser, Benjamin J., Petra F. Mens, Rik B. J. Kraan, Sophia G. de Vries, Selidji T. Agnandji, Peter G. Kremsner, Rosanne W. Wieten, et al. "Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon." American Journal of Tropical Medicine and Hygiene 96, no. 5 (May 3, 2017): 1205–14. http://dx.doi.org/10.4269/ajtmh.16-0721.

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Adegbite, Bayode R., Jean Ronald Edoa, Jamie Rylance, Shevin T. Jacob, Paul Kawale, Ayola A. Adegnika, and Martin P. Grobusch. "Knowledge of health workers relating to sepsis awareness and management in Lambaréné, Gabon." Acta Tropica 219 (July 2021): 105914. http://dx.doi.org/10.1016/j.actatropica.2021.105914.

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Bache, Emmanuel, Marguerite M. Loembe, and Selidji T. Agnandji. "PO 8581 ZOONOTIC VIRAL ANTIGENS SURVEILLANCE IN HEALTHY POPULATIONS LIVING IN LAMBARÉNÉ, GABON." BMJ Global Health 4, Suppl 3 (April 2019): A58.2—A58. http://dx.doi.org/10.1136/bmjgh-2019-edc.153.

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BackgroundWorldwide, viral zoonotic infections such as filoviruses, flaviviruses, nairoviruses and arenaviruses cause self-limiting to severe diseases. They are endemic in sub-Saharan Africa, causing sporadic outbreaks warranting the development of sustainable surveillance systems. In Gabon, Ebola outbreaks occurred from 1994 to 2002 causing 214 human cases and 150 deaths, while Dengue, Zika and Chikungunya virus outbreaks occurred between 2007 and 2010. Beyond these outbreaks, little is known about the epidemiology. Recently, in collaboration with the Japanese government, the Research and Health Ministries of Gabon supported the implementation of a biosecurity level-3 (BSL-3) laboratory at CERMEL in Lambaréné as a zoonotic disease surveillance unit. Start-off involved antigen detection and characterisation of circulating antibodies to targeted viral antigens in healthy populations. This study reports data from healthy participants (18–50 years) in a phase I rVSV-ZEBOV-GP Ebola vaccine trial.MethodsHundred-six (106) baseline samples were screened for Ebola, Dengue (serotypes) 1–4 and Chikungunya viral RNA by RT-PCR on serum. IgG ELISA on plasma was used to identify antibodies against: Zaire-Ebola-(EBOV-GP and EBOV-VP40), Marburg-(MARV-GP and MARV-VP40), Crimean Congo Haemorrhagic Fever-(CCHFV-GP), Lasa-(LASV-GPC and LASV-NP), Yellow Fever-(YFV-NS1), West-Nile-(WNV-NS1), Zika virus-(ZIKV-NS1), Chikungunya-(CHIKV-VLP) and Dengue-(DENV1-NS1,DENV2-NS1,DENV3-NS1,DENV4-NS1) virus antigens.ResultsNo viral RNA was isolated by RT-PCR in 106 samples. About 9% (10/106), 3% (3/106), 6% (6/106), 24% (25/106), 51% (54/106), 38% (40/106) and 36% (38/106) participants were seropositive for antibodies specific to EBOV-GP, MARV-GP, CCHFV-GP, YFV-NS1, WNV-NS1, ZIKV-NS1 and CHIKV-VLP, respectively. Twelve percent (12%; 13/106) of participants possessed antibodies specific to Zika, Chikungunya and Dengue 1–4 antigens. Six percent (6%; 6/106) of participants were seropositive for EBOV-GP and CCHFV-GP.ConclusionWe found antibodies to viral zoonotic infections among our healthy volunteers. Further assays, including neutralisation assays are being performed to ascertain the specificity of the antibodies. These findings, once confirmed, will provide insights into disease surveillance, vaccine trial designs, evaluation of post-vaccine immune responses, variability in adverse events and overall disease transmission patterns.

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Manouana, Gédéon P., Gedeon Bingoulou Matsougou, Natalie Byrne, Philipp Hofmann, mirabeau Mbong Ngwese, Pau A Nguema Moure, Jeannot Fréjus Zinsou, et al. "PO 8444 CHARACTERISATION OF PATHOGENS CAUSING DIARRHOEA IN CHILDREN UNDER FIVE IN LAMBARÉNÉ, GABON." BMJ Global Health 4, Suppl 3 (April 2019): A38.1—A38. http://dx.doi.org/10.1136/bmjgh-2019-edc.99.

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BackgroundDiarrhoeal disease remains the second leading cause of death in children under five years, being associated with about 525,000 deaths every year. The most common pathogens worldwide are Shigella spp/EIEC, rotavirus, adenovirus 40/41, ST-ETEC and Cryptosporidium spp. Public health interventions rely on estimates of pathogen-specific burden for prioritisation. Sadly, comprehensive data on the aetiology of diarrhoea in children is lacking for Gabon. This study aimed to identify the spectrum of pathogens found in Lambaréné, Gabon and provide baseline data on their prevalence, needed for implementation of effective control measures.MethodsA cross-sectional study was conducted at Albert Schweitzer and Georges Rawiri Regional hospitals in Lambaréné from February 2017 to February 2018. A consecutive sample of children under 5 year old with diarrhoea or a history of diarrhoea within the previous three days were prospectively studied. A single stool sample was collected from each study participant and processed using commercial rapid immunoassays to detect antigens of rotavirus, adenovirus, and Cryptosporidium spp. Multiplex PCR was used for Cryptosporidium spp., Giardia lamblia and Cyclospora cayetanensis detection, and characterisation of E. coli strains.ResultsOut of 188 participants who provided stool samples, one or more pathogens could be detected in 34.6% of the cases. The most prevalent parasites were Giardia lamblia (14.9%), Cryptosporidium spp. (11.7%), and Cyclospora cayetanensis (2.7%). Enteric viruses also were identified in these children: 10.6% and 1.6% of rotavirus and adenovirus, respectively. Multiple pathogens were detected in 5.3% of samples.ConclusionThis analysis of the causes of diarrhoea in children under 5 years of age in our setting showed three main pathogens: Giardia lamblia, Cryptosporidium spp. and rotavirus. Our study confirms major agents of acute diarrhoeal diseases in children, highlights research needs (Cryptosporidium) and supports the introduction of new tools such as the implementation of the rotavirus vaccine in the national immunisation programme.

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Manouana, Gédéon Prince, Natalie Byrne, Mirabeau Mbong Ngwese, Alvyn Nguema Moure, Philipp Hofmann, Gedeon Bingoulou Matsougou, Fabrice Lotola Mougeni, et al. "Prevalence of Pathogens in Young Children Presenting to Hospital with Diarrhea from Lambaréné, Gabon." American Journal of Tropical Medicine and Hygiene 105, no. 1 (July 7, 2021): 254–60. http://dx.doi.org/10.4269/ajtmh.20-1290.

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Abstract.Diarrheal disease is the second most frequent cause of mortality in children younger than 5 years worldwide, causing more than half a million deaths each year. Our knowledge of the epidemiology of potentially pathogenic agents found in children suffering from diarrhea in sub-Saharan African countries is still patchy, and thereby hinders implementation of effective preventative interventions. The lack of cheap, easy-to-use diagnostic tools leads to mostly symptomatic and empirical case management. An observational study with a total of 241 participants was conducted from February 2017 to August 2018 among children younger than 5 years with diarrhea in Lambaréné, Gabon. Clinical and demographic data were recorded, and a stool sample was collected. The samples were examined using a commercial rapid immunoassay to detect Rotavirus/adenovirus, conventional bacterial culture for Salmonella spp., and multiplex real-time PCR for Cryptosporidium spp., Giardia lamblia, Cyclospora cayetanensis, enterotoxigenic Escherichia coli (ETEC), and enteroinvasive Escherichia coli (EIEC)/Shigella. At least one infectious agent was present in 121 of 241 (50%) samples. The most frequently isolated pathogens were EIEC/Shigella and ETEC (54/179; 30.2% and 44/179; 24.6%, respectively), followed by G. lamblia (33/241; 13.7%), Cryptosporidium spp. (31/241; 12.9%), and Rotavirus (23/241; 9.5%). Coinfection with multiple pathogens was observed in 33% (40/121) of the positive cases with EIEC/Shigella, ETEC, and Cryptosporidium spp. most frequently identified. Our results provide new insight into the possible causes of diarrheal disease in the Moyen-Ogooué region of Gabon and motivate further research on possible modes of infection and targeted preventive measures.

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Kun, J. F., M. Alpers, D. Luckner, P. G. Kremsner, B. Lell, J. Klabunde, C. Meyer, and J. May. "Association of the ICAM-1Kilifi mutation with protection against severe malaria in Lambaréné, Gabon." American Journal of Tropical Medicine and Hygiene 61, no. 5 (November 1, 1999): 776–79. http://dx.doi.org/10.4269/ajtmh.1999.61.776.

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Dejon-Agobé, Jean Claude, Yabo Josiane Honkpehedji, Jeannot Fréjus Zinsou, Jean Ronald Edoa, Bayodé Roméo Adégbitè, Ance Mangaboula, Selidji Todagbe Agnandji, et al. "Epidemiology of Schistosomiasis and Soil-Transmitted Helminth Coinfections among Schoolchildren Living in Lambaréné, Gabon." American Journal of Tropical Medicine and Hygiene 103, no. 1 (July 8, 2020): 325–33. http://dx.doi.org/10.4269/ajtmh.19-0835.

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Stolp, S. M., M. A. M. Huson, S. Janssen, J. O. Beyeme, and M. P. Grobusch. "Tuberculosis patients hospitalized in the Albert Schweitzer Hospital, Lambaréné, Gabon—a retrospective observational study." Clinical Microbiology and Infection 19, no. 11 (November 2013): E499—E501. http://dx.doi.org/10.1111/1469-0691.12278.

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Ramharter, Michael, Ayola A. Adegnika, Selidji T. Agnandji, Pierre Blaise Matsiegui, Martin P. Grobusch, Stefan Winkler, Wolfgang Graninger, et al. "History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon." Wiener klinische Wochenschrift 119, S3 (November 2007): 8–12. http://dx.doi.org/10.1007/s00508-007-0857-5.

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Minto'o, Steeve, Fifi Claire Loembe, Midili Thècle Larissa, Mireille Mensan Pemba, Koumba Maniaga Raïssa, Mylène Mimbila-Mayi, Yolande Nzame, et al. "Duration and Sociodemographic Factors Associated with Exclusive Breastfeeding Among Mothers in Urban and Semi-Rural Areas of Libreville and Lambaréné in Gabon." Archives of Pediatric Gastroenterology, Hepatology, and Nutrition 3, no. 1 (February 29, 2024): 1–11. http://dx.doi.org/10.58427/apghn.3.1.2024.1-11.

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Background: Exclusive breastfeeding from birth to six months of age has an unparalleled benefit on a child's growth and development. This survey aimed to assess the practice of exclusive breastfeeding (EBF) in Libreville and Lambaréné. Method: This is a prospective study, including mother-child pairs of infants taken to vaccination centers in Libreville (urban area) and Lambaréné (semi-rural area). The data collected included sociodemographic aspects of families, the children's characteristics, and the duration of EBF in months. Result: We included 552 mother-child pairs, 58% of whom were recruited (n = 320) in Libreville. The average age of mothers was 26.5 ± 6.4 years, while fathers were 33.3 ± 7.8 years. The mean age of children was 4.2 ± 3.1 months. Male participants were accounted for 52.2% (n = 288), while females 47.8% (n = 264). The mean duration of exclusive breastfeeding in the whole was 0.9 months. Six-month EBF was generally performed at 9.2% (n = 51, 95% CI = 7.1%-11.9%). The factors influencing the EBF were father’s level of education (all classes combined) (p = 0.025), marital status (p = 0.011), and residential area (OR = 3.40, p <0.001) Conclusion: The duration of exclusive breastfeeding in the two studied is lower than the WHO recommendations. The associated factors found are areas of work to be explored to encourage this important practice for our infants.

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V Ndong Mbouna, Armel, and Selidji T Agnandji. "PO 8559 ASSESSMENT OF THE EFFECT OF RVSV REPLICATION ON NON-EBOLA CIRCULATING ANTIBODIES IN RVSV-ZEBOV-GP-VACCINATED INDIVIDUALS IN LAMBARÉNÉ, GABON." BMJ Global Health 4, Suppl 3 (April 2019): A53.1—A53. http://dx.doi.org/10.1136/bmjgh-2019-edc.138.

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BackgroundThe West Africa Ebola virus disease (EVD) outbreak between 2015 and 2016 accelerated the need for safe and effective vaccines. Among candidate vaccines in clinical development, the recombinant Vesicular stomatitis virus (VSV) vectored with the Ebola virus (EBOV) glycoprotein (rVSV-ZEBOV-GP) vaccine showed acceptable safety and promising immunogenicity results across diverse settings.Baseline screening data from the phase I trial of this vaccine in Lambaréné, Gabon, established that prior to vaccination about 21% (33/155) and 8% (12/155) of adults had naturally acquired antibodies to infectious ZEBOV particle and ZEBOV-GP, respectively. In participants with prior ZEBOV(-GP) antibodies, post-vaccination antibodies titres were significantly higher 56 days following vaccination with doses of 3×103, 3×104, and 3×106 PFU compared to those without.Our study seeks to investigate rVSV vector non-specific boosting of naturally acquired antibodies to other viral infections (dengue virus 1–4, and yellow fever virus).MethodsWe measured antibodies titres to Dengue (serotypes 1–4) and yellow fever infection at baseline, 28 and 56 days after injection in a total of 155 serum samples from vaccinees receiving various doses of rVSV-ZEBOV-GP using ELISA technique.ResultsPreliminary results were presented at the meeting.ConclusionOur results confirm rVSV vector non-specific replication on non ZEBOV-GP circulating antibodies in Lambaréné vaccinees and potential boosting action on naturally acquired dengue virus (serotypes 1–4) and yellow fever virus antibodies.

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Claude Dejon Agobe, Jean, Yabo J Honkpehedji, Jeannot Fréjus Zinsou, Jean-Ronald Edoa, Bayodé R Adegbite, Mohamed Duali, Fabrice L Mougeni, et al. "PO 8503 EPIDEMIOLOGY, CO-INFECTIONS AND HAEMATOLOGICAL FEATURES OF SCHISTOSOMIASIS IN SCHOOL-AGED CHILDREN LIVING IN LAMBARÉNÉ, GABON." BMJ Global Health 4, Suppl 3 (April 2019): A47.1—A47. http://dx.doi.org/10.1136/bmjgh-2019-edc.123.

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BackgroundSchistosomiasis is a highly prevalent parasitic infection in Central Africa, where co-endemicity with other parasitic infections is common, and schistosomiasis outcomes can be affected by those other infections. Therefore, proper schistosomiasis control needs epidemiological data accounting for co-infections, too. In this present study, our objective was to determine the epidemiological situation around schistosomiasis in Lambaréné.MethodsA cross-sectional study was conducted among school-aged children living in Lambaréné. Urine filtration exam was performed for the detection of Schistosoma eggs. Kato-Katz and stool culture (Coproculture and Harada-Mori) techniques were used for the detection of soil-transmitted helminths. Detection of Plasmodium spp. and blood microfilariae was performed applying light microscopy. Risk factors for schistosomiasis and factors associated with schistosomiasis were investigated; haematology parameters evaluated.ResultsA total of 614 school children with available schistosomiasis status were included in the analysis. Mean age was 10.9 (SD=2.7) years, with a 0.95 boy-to-girl sex ratio. The prevalence of schistosomiasis was 26%. No risk factors except human-water contact were associated with schistosomiasis. Only Trichuris trichiura co-infection was associated with an increased odd (aOR=2.3, p-value=0.048) to be infected with schistosomiasis. Full blood counts showed a decrease of haemoglobin level and increase of WBC and platelet levels among the schistosoma-infected children. Haematuria was found associated with schistosomiasis (aOR=14.5, p-value<0.001) and was suitable to predict the disease.ConclusionThe prevalence of schistosomiasis is moderate in Lambaréné where human-water contact remains the main risk factor and praziquantel is available for treatment. Trichuriasis is associated with increased risk to be infected. Children with schistosomiasis exhibit a distinct full blood count profile and haematuria is found to be more suitable to predict infection. However, it is desirable to implement comprehensive approaches beyond chemotherapy for schistosomiasis control in this area as recommended by WHO.

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Goldwyn, Robert M., and Mark B. Constantian. "The Goldwyn Diary of November and December 1960, at the Albert Schweitzer Hospital, Lambaréné, Gabon." Plastic and Reconstructive Surgery 129, no. 1 (January 2012): 281–83. http://dx.doi.org/10.1097/prs.0b013e3182362c9a.

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Wurmser, C., A. Roos, C. Kokou, C. Metz-Favre, and G. Pauli. "Étude de l’asthme de l’enfant en milieu semi-rural au Gabon (Hôpital Albert Schweitzer, Lambaréné)." Revue Française d'Allergologie 55, no. 3 (April 2015): 257. http://dx.doi.org/10.1016/j.reval.2015.02.140.

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Wurmser, C., A. Roos, C. Kokou, C. Metz-Favre, C. Lupinek, F. De Blay, and G. Pauli. "Étude de l’asthme de l’enfant en milieu semi-rural au Gabon (hôpital Albert-Schweitzer, Lambaréné)." Revue Française d'Allergologie 57, no. 1 (February 2017): 2–7. http://dx.doi.org/10.1016/j.reval.2016.09.005.

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Cremers, A. L., S. Janssen, M. A. M. Huson, G. Bikene, S. Bélard, R. P. M. Gerrets, and M. P. Grobusch. "Perceptions, health care seeking behaviour and implementation of a tuberculosis control programme in Lambaréné, Gabon." Public Health Action 3, no. 4 (December 21, 2013): 328–32. http://dx.doi.org/10.5588/pha.13.0038.

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Mimbila, M. M., R. S. Minto’o, M. N. E. Mintsa, K. E. Kuissi, U. Bisvigou, J. Koko, and S. Ategbo. "Indication and Outcomes of Paediatric Blood Transfusion at Three Hospitals in Gabon, Africa." Africa Sanguine 22, no. 1 (May 25, 2020): 10–13. http://dx.doi.org/10.4314/asan.v22i1.2.

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Introduction: Blood transfusion is a life-saving treatment for severely anaemic children both in developed and developing countries. In this study we describe transfusions in paediatric settings of Gabon, Africa including clinical indications and subsequent outcomes.Methods: This prospective descriptive study was conducted in the cities of Libreville and Lambaréné from 1 January to 30 September 2016.Children between the ages of 1 month and 15 years, who were hospitalised and transfused were included in the study.Results: We included 287 children who represented 17.1% of all hospitalised children. The male:female ratio was 0.95 and the average age was 3.7 years. Packed red blood cells (PRBC) were administered to 99.3% of anaemic patients. World Health Organization (WHO) defined severe anaemia (haemoglobin (Haemoglobin) <7 g/dL) was the main indication (95.1%) with the mean haemoglobin (Hb) level pretransfusion being 5.1 g/dL ± 2.7 g/dL, and post-transfusion haemoglobin gain being 2.9 g/dL ± 1.2 g/dL. Malaria was present in 79% of transfused patients and 46.9% of children screened were homozygous for sickle cell disease. No post-transfusion incident was reported although reporting may have been incomplete.Conclusion: Blood transfusion is frequent in our context; the clinical outcome is mostly favourable. French Title: Indication et Résultats de la Transfusion Sanguine Pédiatrique Dans Trois Hôpitaux au Gabon, en Afrique Introduction: La transfusion sanguine est un traitement salvateur pour les enfants gravement anémiés dans les pays développés ou endéveloppement. Dans cette étude, nous décrivons les transfusions en milieu pédiatrique du Gabon, en Afrique, y compris les indicationscliniques et les résultats.Méthodes: Cette étude descriptive prospective a été réalisée dans les villes de Libreville et Lambaréné du 1er janvier au 30 septembre 2016.Les enfants âgés de 1 mois à 15 ans, hospitalisés et transfusés ont été inclus dans l'étude.Résultats: Nous avons inclus 287 enfants qui représentaient 17.1% de tous les enfants hospitalisés. Le rapport garçons/filles était de 0.95 etl'âge moyen était de 3.7 ans. Des concentrés de globules rouges (CGR) ont été administrés à 99.3% des patients anémiques. L’anémie définiepar l’Organisation Mondiale de la Santé (OMS) (hémoglobine <7 g/dL) était la principale indication (95.1%), le taux moyen d'hémoglobine(Hb) avant transfusion étant de 5.1 g/dL ± 2.7 g/dL, et le gain d'hémoglobine après transfusion était de 2.9 g/dL ± 1.2 g/dL. Le paludisme étaitprésent chez 79% des patients transfusés et 46.9% des enfants dépistés étaient homozygotes pour la drépanocytose. Aucun incident post transfusionnel n'a été signalé, bien que le signalement ait pu être incomplet.Conclusion: La transfusion sanguine est fréquente dans notre contexte; l'issue clinique est généralement favorable.

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Zoleko-Manego, Rella, Johannes Mischlinger, Jean Claude Dejon-Agobé, Arti Basra, J. Rodolphe Mackanga, Daisy Akerey Diop, Ayola Akim Adegnika, et al. "Birth weight, growth, nutritional status and mortality of infants from Lambaréné and Fougamou in Gabon in their first year of life." PLOS ONE 16, no. 2 (February 9, 2021): e0246694. http://dx.doi.org/10.1371/journal.pone.0246694.

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Background Malnutrition and low birth weight (LBW) are two common causes of morbidity and mortality among children in sub-Saharan Africa. Both malnutrition and LBW affect early childhood development with long term consequences that may vary in their degree depending on the geographical setting. This study evaluates growth, nutritional status and mortality of infants from Lambaréné and Fougamou in Gabon from a birth cohort of a malaria in pregnancy clinical trial (NCT00811421). Method A prospective longitudinal birth cohort conducted between 2009 and 2012, included infants that were followed up from birth until their first-year anniversary. The exposure of interest was low birth weight and the outcomes explored were growth represented by weight gain, the nutritional status including stunting, wasting and underweight, and the mortality. Scheduled follow-up visits were at one, nine and 12 months of age. Logistic regression was used to assess the association between low birth weight and growth and nutritional outcomes, and cox regression was used for mortality. Result A total of 907 live-born infants were included in the analysis. The prevalence of LBW was 13% (115). At one month of life, out of 743 infants 10% and 4% presented with stunting and underweight, respectively, while these proportions increased at 12 months of life to 17% and 21%, respectively, out of 530 infants. The proportion of infants with wasting remained constant at 7% throughout the follow-up period. Stunting and underweight were associated with LBW, adjusted odds ratio (aOR): 2.6, 95% confidence interval (95%CI): 1.4–4.9 and aOR: 4.5, 95%CI: 2.5–8.1, respectively. Preterm birth was associated with stunting, aOR: 2.7, 95%CI: 1.2–6.3 and underweight, aOR: 5.4, 95%CI: 1.7–16.1 at one month of life. Infants with LBW were at higher hazard of death during the first year of life, adjusted hazard ratio 4.6, 95%CI: 1.2–17.0. Conclusion Low birthweight infants in Gabon are at higher risks of growth and nutritional deficits and mortality during the first year of life. Tailored interventions aiming at preventing adverse pregnancy outcomes including LBW, early detection and appropriate management of growth, and nutritional deficits in infants are necessary in Gabon.

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Schwarz, Norbert G., Marjolein Gysels, Christopher Pell, Julian Gabor, Meike Schlie, Saadou Issifou, Bertrand Lell, Peter G. Kremsner, Martin P. Grobusch, and Robert Pool. "Reasons for non-adherence to vaccination at mother and child care clinics (MCCs) in Lambaréné, Gabon." Vaccine 27, no. 39 (August 2009): 5371–75. http://dx.doi.org/10.1016/j.vaccine.2009.06.100.

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Cremers, A. L., S. Janssen, M. A. M. Huson, G. Bikene, S. Bélard, R. P. M. Gerrets, and M. P. Grobusch. "Perceptions, health care seeking behaviour and the implementation of a tuberculosis control program in Lambaréné, Gabon." International Journal of Infectious Diseases 21 (April 2014): 227. http://dx.doi.org/10.1016/j.ijid.2014.03.893.

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Dibacka, Paterne Lessihuin, Yann Bounda, Davy Ondo Nguema, and Bertrand Lell. "Developing Information Technology at the Medical Research Unit of the Albert Schweitzer Hospital in Lambaréné, Gabon." Wiener klinische Wochenschrift 122, S1 (March 2010): 16–18. http://dx.doi.org/10.1007/s00508-010-1329-x.

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Manego, Rella Zoleko, Eric Koehne, and Ghyslain Mombo-Ngoma. "PO 8563 UNCOMMONLY HIGH AND SYMPTOMATIC PLASMODIUM FALCIPARUM INFECTIONS IN GABONESE ADULTS." BMJ Global Health 4, Suppl 3 (April 2019): A53.3—A53. http://dx.doi.org/10.1136/bmjgh-2019-edc.140.

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BackgroundMalaria remains a public health issue particularly in sub-Saharan Africa with special features of seriousness in young children and pregnant women. Older children and adults reported to have acquired a semi-immune status and therefore show low parasitaemia and less pronounced symptoms if any. We aim to explore parasitaemia and symptoms in adolescents and adults with malaria compared to younger children in the Lambaréné area.MethodsWe conducted a cross-sectional study in CERMEL for a month in 2018. Adults and children were screened for malaria at health facilities in Lambaréné and Fougamou and their respective surrounding villages in the central region of Gabon. Malaria infection was determined either by rapid diagnostic test (RDT) or by thick blood smear (TBS). Body temperature, history of fever, age, sex, haemoglobin level, and location were collected.ResultsFrom 09 January to 09 February 2018, a total of 596 patients were screened and 280 (47%) belonged to the adult population. Plasmodium falciparum infection in adults was diagnosed based on the detection of P. falciparum in thick blood films. Prevalence among the adults was 56% (n=141); 34% of adult patients had a parasite count between 1015–116,079 pf/µl. Fever was found in 31% of adults and several symptoms were reported by the same patient. Vomiting, loss of appetite, and fatigue were significantly more present in the adult population than in children.ConclusionThis study shows a high rate of Plasmodium falciparum infection in adults associated to clinical symptoms and high level of parasitaemia. Adults seem to become an at-risk population, suggesting that malaria programmes should consider including adults in the implementation of a malaria prevention programme.

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Schwarz, Norbert G., Martin P. Grobusch, Marie-Luise Decker, Julia Goesch, Marc Poetschke, Sunny Oyakhirome, Davy Kombila, et al. "WHO 2006 child growth standards: implications for the prevalence of stunting and underweight-for-age in a birth cohort of Gabonese children in comparison to the Centers for Disease Control and Prevention 2000 growth charts and the National Center for Health Statistics 1978 growth references." Public Health Nutrition 11, no. 7 (July 2008): 714–19. http://dx.doi.org/10.1017/s1368980007001449.

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AbstractObjectivesTo assess the proportion of children being stunted and underweight-for-age at 3, 9 and 15 months in Lambaréné, Gabon, using the WHO child growth standards released in 2006 as compared with the Centers for Disease Control and Prevention (CDC) 2000 and the National Center for Health Statistics (NCHS) 1978 child growth charts/references.Design and settingProspective birth cohort in Lambaréné, Gabon.SubjectsTwo hundred and eighty-nine children from birth to 15 months of age.MethodsWeight and length were recorded at 3, 9 and 15 months. CorrespondingZscores for stunting and underweight-for-age were calculated for the three different standards/references. Children with a height-for-age or weight-for-age below –2sdof the corresponding reference median (Zscore ≤−2) were classified as stunted or underweight-for-age, respectively.ResultsWith the new WHO 2006 standards a higher proportion (4·0 %) of 3-month-old infants were underweight compared with the CDC (1·0 %) or the NCHS (0·7 %) child growth charts/references. In contrast to the NCHS references or the CDC charts, this proportion did not increase from 3 to 9 months or from 9 to 15 months. The proportion of children being stunted was highest (above 20 %) with the WHO 2006 standards at all three ages. Again, in contrast to the old standards, this proportion did not increase from 3 to 9 months or from 9 to 15 months.ConclusionsThe present results show considerably different growth faltering patterns for Gabonese children depending on the growth charts used to assess the prevalence of stunting and underweight. Shifting to the new WHO child growth standards may have important implications for child health programmes.

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Huttner, Angela, Christophe Combescure, Stéphane Grillet, Mariëlle C. Haks, Edwin Quinten, Christine Modoux, Selidji Todagbe Agnandji, et al. "A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa." Science Translational Medicine 9, no. 385 (April 12, 2017): eaaj1701. http://dx.doi.org/10.1126/scitranslmed.aaj1701.

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The 2014–2015 Ebola epidemic affected several African countries, claiming more than 11,000 lives and leaving thousands with ongoing sequelae. Safe and effective vaccines could prevent or limit future outbreaks. The recombinant vesicular stomatitis virus–vectored Zaire Ebola (rVSV-ZEBOV) vaccine has shown marked immunogenicity and efficacy in humans but is reactogenic at higher doses. To understand its effects, we examined plasma samples from 115 healthy volunteers from Geneva who received low-dose (LD) or high-dose (HD) vaccine or placebo. Fifteen plasma chemokines/cytokines were assessed at baseline and on days 1, 2 to 3, and 7 after injection. Significant increases in monocyte-mediated MCP-1/CCL2, MIP-1β/CCL4, IL-6, TNF-α, IL-1Ra, and IL-10 occurred on day 1. A signature explaining 68% of cytokine/chemokine vaccine-response variability was identified. Its score was higher in HD versus LD vaccinees and was associated positively with vaccine viremia and negatively with cytopenia. It was higher in vaccinees with injection-site pain, fever, myalgia, chills, and headache; higher scores reflected increasing severity. In contrast, HD vaccinees who subsequently developed arthritis had lower day 1 scores than other HD vaccinees. Vaccine dose did not influence the signature despite its influence on specific outcomes. The Geneva-derived signature associated strongly (ρ = 0.97) with that of a cohort of 75 vaccinees from a parallel trial in Lambaréné, Gabon. Its score in Geneva HD vaccinees with subsequent arthritis was significantly lower than that in Lambaréné HD vaccinees, none of whom experienced arthritis. This signature, which reveals monocytes’ critical role in rVSV-ZEBOV immunogenicity and safety across doses and continents, should prove useful in assessments of other vaccines.

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Adegbite, Bayode Romeo, Jean Ronald Edoa, Pacome Achimi Agbo, Jean Claude Dejon-Agobé, Paulin N Essone, Fabrice Lotola-Mougeni, Mirabeau Mbong Ngwese, et al. "Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon: A Cross-Sectional Study." American Journal of Tropical Medicine and Hygiene 103, no. 6 (December 2, 2020): 2501–5. http://dx.doi.org/10.4269/ajtmh.20-0424.

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ADEGNIKA, AYÔLA A., SELIDJI T. AGNANDJI, SAADOU ISSIFOU, DANIELA SCHÜTTE, NORBERT G. SCHWARZ, LUTZ PH BREITLING, MICHEL A. MISSINOU, et al. "EFFECTIVENESS OF QUININE MONOTHERAPY FOR THE TREATMENT OF PLASMODIUM FALCIPARUM INFECTION IN PREGNANT WOMEN IN LAMBARÉNÉ, GABON." American Journal of Tropical Medicine and Hygiene 73, no. 2 (August 1, 2005): 263–66. http://dx.doi.org/10.4269/ajtmh.2005.73.263.

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Matthewman, Julian, Rella Zoleko Manego, Lia Betty Dimessa Mbadinga, Hana Šinkovec, Katrin Völker, Malik Akinosho, Christian Haedrich, et al. "A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon." PLOS Neglected Tropical Diseases 14, no. 6 (June 26, 2020): e0008423. http://dx.doi.org/10.1371/journal.pntd.0008423.

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Mordmüller, Benjamin, Katja Szywon, Benedikt Greutelaers, Meral Esen, Ludovic Mewono, Carolin Treut, Raymund E. Mürbeth, et al. "Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon." Vaccine 28, no. 41 (September 2010): 6698–703. http://dx.doi.org/10.1016/j.vaccine.2010.07.085.

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Flügge, Judith, Ayôla Akim Adegnika, Yabo Josiane Honkpehedji, Thaisa L. Sandri, Esther Askani, Gédéon Prince Manouana, Marguerite Massinga Loembe, et al. "Impact of Helminth Infections during Pregnancy on Vaccine Immunogenicity in Gabonese Infants." Vaccines 8, no. 3 (July 11, 2020): 381. http://dx.doi.org/10.3390/vaccines8030381.

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Helminth infections are common in sub-Saharan Africa. Besides direct clinical effects, a bias towards a T helper type 2 (Th2) cell immune response is observed. The consequences of parasite infection during pregnancy for the mother and particularly for the fetus and the newborn can be severe and may include impaired immune response during acute infection and vaccination. Here, we present data of immune responses to vaccines given within the expanded program on immunization (EPI) of infants born to helminth infected or non-infected mothers. The study was conducted in Lambaréné and surroundings, Gabon. Maternal helminth infection was diagnosed microscopically using the Kato-Katz method for soil-transmitted helminths (STH), urine filtration for Schistosoma haematobium infections and the saponin-based method for filarial infections. Plasma antibody levels to different vaccine antigens were measured in mothers and their offspring by enzyme-linked immunosorbent assay (ELISA) at different timepoints. We found 42.3% of the mothers to be infected with at least one helminth species. Significantly lower anti-tetanus toxoid immunoglobulin (Ig) G was detected in the cord blood of infants born to helminth infected mothers. Following vaccination, immune responses of the infants to EPI vaccines were similar between the two groups at nine and 12 months. Even though infection with helminths is still common in pregnant women in Gabon, in our setting, there was no evidence seen for a substantial effect on infants’ immune responses to vaccines given as part of the EPI.

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Janssen, Saskia, Sabine Hermans, Martijn Knap, Alma Moekotte, Elie G. Rossatanga, Akim A. Adegnika, Sabine Bélard, Thomas Hänscheid, and Martin P. Grobusch. "Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon." PLOS Neglected Tropical Diseases 9, no. 5 (May 20, 2015): e0003769. http://dx.doi.org/10.1371/journal.pntd.0003769.

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Fernandes, José, Emmanuel B. Bache, Régis M. Obiang Mba, Anita L. Kabwende, Benjamin Mordmüller, Sanjeev Krishna, Peter G. Kremsner, Martin P. Grobusch, and Agnandji Selidji Todagbe. "SAFETY OF RVSV EBOLA VACCINE, AFTER 6 MONTHS FOLLOW-UP, IN ADULTS: A PHASE 1 TRIAL CONDUCTED IN LAMBARÉNÉ, GABON." BMJ Global Health 2, Suppl 2 (February 2017): A67.1—A67. http://dx.doi.org/10.1136/bmjgh-2016-000260.179.

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Dejon Agobé, Jean Claude, Jean R Edoa, Yabo J Honkpehedji, Jeannot Fréjus Zinsou, Bayodé R Adegbité, Bertrand Lell, Martin P Grobusch, Benjamin Mordmüller, and Ayola Akim Adegnika. "PO 8449 SCHISTOSOMA HAEMATOBIUM INFECTION INCREASES THE NUMBER OF MALARIA EPISODES IN CHILDREN LIVING IN RURAL AREAS AROUND LAMBARéNé, GABON." BMJ Global Health 4, Suppl 3 (April 2019): A39.3—A40. http://dx.doi.org/10.1136/bmjgh-2019-edc.103.

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BackgroundIn sub-Saharan Africa, Plasmodium spp. infection prevalence very often overlaps with helminth infections, particularly with schistosomiasis which is reported to be the second parasitic infection after malaria in terms of prevalence. Interaction between both infections has been reported earlier. Schistosomiasis is typically a chronic disease, whereas malaria occurs in episodes, particularly in children. In this study, we assessed the effect of Schistosoma haematobium infection on clinical malaria among children.MethodsA longitudinal study was conducted from June 2016 to February 2018. Volunteers without any known chronic condition were included. Thick blood smear (TBS) was performed monthly at participants’ homes. For any medical concern including malaria-like symptoms and visible haematuria, participants were invited to come to CERMEL for diagnosis and treatment. Light microscopy was performed to detect malaria parasites and Schistosoma eggs, using TBS and urine filtration technique, respectively. Over the study course, participants found to be infected were treated accordingly. Schistosomiasis status was determined at the end of the follow-up.ResultsAmong the 351 volunteers included in the study, schistosomiasis status was available for 260. Mean age was 12.3 year (SD 4.6) with a 0.96 women-to-men sex ratio. Of those, 112/260 (43.1%) [37.0%–49.3%] participants were positive for S. haematobium, and a total of 132 (51%) children developed 230 malaria attacks. Those with schistosomiasis had a 1.5:1 [1.1–2.0] risk to develop malaria compared to their uninfected counterparts. The mean number of malaria episodes per child over the study course was higher among children with schistosomiasis compared to those without (2.03 vs 1.57, p-value=0.015).ConclusionS. haematobium infection was associated with increased susceptibility to develop malaria (by increasing the risk to develop a malaria episode) and, consequently, a higher malaria incidence.

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Kun, Jürgen F. T., Ruprecht J. Schmidt-Ott, Leopold G. Lehman, Bertrand Lell, Doris Luckner, Bernhard Greve, Peter Matousek, and Peter G. Kremsner. "Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambaréné, Gabon." Transactions of the Royal Society of Tropical Medicine and Hygiene 92, no. 1 (January 1998): 110–14. http://dx.doi.org/10.1016/s0035-9203(98)90979-8.

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Agnandji, Selidji T., José F. Fernandes, Emmanuel B. Bache, Régis M. Obiang Mba, Jessica S. Brosnahan, Lumeka Kabwende, Paul Pitzinger, et al. "Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial." PLOS Medicine 14, no. 10 (October 6, 2017): e1002402. http://dx.doi.org/10.1371/journal.pmed.1002402.

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Kombila, U. D., J. Iba Ba, G. Tsoumbou-Bakana, and J. B. Moussavou Kombila. "Non-adherence to antiretroviral therapy in patients infected with HIV and cryptococcal meningitis: two cases at the Lambaréné Hospital Center in Gabon." Médecine et Santé Tropicales 26, no. 4 (October 2016): 446–48. http://dx.doi.org/10.1684/mst.2016.0603.

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Lumeka, Kabwende, and Agnandji Todagbe. "INVOLVEMENT OF STAKEHOLDERS IN THE REPORTING PROCESS OF SERIOUS ADVERSE EVENTS DURING CLINICAL TRIALS IN A SUB-SAHARAN RESEARCH CENTER, LAMBARÉNÉ, GABON." BMJ Global Health 2, Suppl 2 (February 2017): A63.2—A63. http://dx.doi.org/10.1136/bmjgh-2016-000260.169.

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Zoleko-Manego, Rella, Dearie G. Okwu, Christian Handrich, Lia B. Dimessa-Mbadinga, Malick A. Akinosho, Wilfrid F. Ndzebe-Ndoumba, Saskia D. Davi, et al. "Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study." PLOS Neglected Tropical Diseases 16, no. 10 (October 31, 2022): e0010899. http://dx.doi.org/10.1371/journal.pntd.0010899.

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Background Urogenital schistosomiasis is prevalent in many malaria endemic regions of sub-Saharan Africa and can lead to long-term health consequences if untreated. Antimalarial drugs used to treat uncomplicated malaria have shown to exert some activity against Schistosoma haematobium. Here, we explore the efficacy on concomitant urogenital schistosomiasis of first-line recommended artemisinin-based combination therapies (ACTs) and investigational second-generation ACTs when administered for the treatment of uncomplicated malaria in Gabon. Methods Microscopic determination of urogenital schistosomiasis was performed from urine samples collected from patients with confirmed uncomplicated malaria. Egg excretion reduction rate and cure rate were determined at 4-weeks and 6-weeks post-treatment with either artesunate-pyronaridine, artemether-lumefantrine, artesunate-amodiaquine or artefenomel-ferroquine. Results Fifty-two (16%) out of 322 malaria patients were co-infected with urogenital schistosomiasis and were treated with antimalarial drug combinations. Schistosoma haematobium egg excretion rates showed a median reduction of 100% (interquartile range (IQR), 17% to 100%) and 65% (IQR, -133% to 100%) at 4-weeks and 6-weeks post-treatment, respectively, in the artesunate-pyronaridine group (n = 20) compared to 35% (IQR, −250% to 70%) and 65% (IQR, -65% to 79%) in the artemether-lumefantrine group (n = 18). Artesunate-amodiaquine (n = 2) and artefenomel-ferroquine combination (n = 3) were not able to reduce the rate of eggs excreted in this limited number of patients. In addition, cure rates were 56% and 37% at 4- and 6-weeks post-treatment, respectively, with artesunate-pyronaridine and no cases of cure were observed for the other antimalarial combinations. Conclusions Antimalarial treatments with artesunate-pyronaridine and artemether-lumefantrine reduced the excretion of S. haematobium eggs, comforting the hypothesis that antimalarial drugs could play a role in the control of schistosomiasis. Trial Registration This trial is registered with clinicaltrials.gov, under the Identifier NCT04264130.

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R., Binder, Borrmann S., Adegnika A., Missinou M., Kremsner P., and Kun J. "Polymorphisms in the parasite genes for pfcrt and pfmdr-1 as molecular markers for chloroquine resistance in Plasmodium falciparum in Lambaréné, Gabon." Parasitology Research 88, no. 5 (May 1, 2002): 475–76. http://dx.doi.org/10.1007/s00436-001-0546-7.

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