Relevant bibliographies by topics / Laminin cellular adhesion

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Laminin cellular adhesion'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "Laminin cellular adhesion"

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Gu, Yu-Chen, Jarkko Kortesmaa, Karl Tryggvason, et al. "Laminin isoform–specific promotion of adhesion and migration of human bone marrow progenitor cells." Blood 101, no. 3 (2003): 877–85. http://dx.doi.org/10.1182/blood-2002-03-0796.

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Abstract Laminins are αβγ heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing α4 and α5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. We studied human bone marrow cell adhesion to laminin-10/11 (α5β1γ1/α5β2γ1), laminin-8 (α4β1γ1), laminin-1 (α1β1γ1), and fibronectin. About 35% to 40% of CD34+ and CD34+CD38− stem and progenitor cells adhered to laminin-10/11, and 45% to 50% adhered to fibronectin, whereas they adhered less to laminin-8 and laminin-1
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Klees, Robert F., Roman M. Salasznyk, Karl Kingsley, William A. Williams, Adele Boskey, and George E. Plopper. "Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-dependent Pathway." Molecular Biology of the Cell 16, no. 2 (2005): 881–90. http://dx.doi.org/10.1091/mbc.e04-08-0695.

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The laminin family of proteins is critical for managing a variety of cellular activities including migration, adhesion, and differentiation. In bone, the roles of laminins in controlling osteogenic differentiation of human mesenchymal stem cells (hMSC) are unknown. We report here that laminin-5 is found in bone and expressed by hMSC. hMSC isolated from bone synthesize laminin-5 and adhere to exogenous laminin-5 through α3β1 integrin. Adhesion to laminin-5 activates extracellular signal-related kinase (ERK) within 30 min and leads to phosphorylation of the osteogenic transcription factor Runx2/
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Desban, N., and J. L. Duband. "Avian neural crest cell migration on laminin: interaction of the alpha1beta1 integrin with distinct laminin-1 domains mediates different adhesive responses." Journal of Cell Science 110, no. 21 (1997): 2729–44. http://dx.doi.org/10.1242/jcs.110.21.2729.

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In the present study, to further elucidate the molecular events that control neural crest cell migration, we have analyzed in vitro the adhesive and locomotory response of avian trunk neural crest cells to laminin-1 and searched for the integrin receptors involved in this process. Adhesion of crest cells on laminin-1 was comparable to that found on fibronectin or vitronectin. By contrast, migration was significantly greater on laminin-1 than on the other substrate molecules. Interaction of crest cells with laminin-1 involved two major cell-binding domains situated in different portions of the
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Delwel, G. O., A. A. de Melker, F. Hogervorst, et al. "Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms." Molecular Biology of the Cell 5, no. 2 (1994): 203–15. http://dx.doi.org/10.1091/mbc.5.2.203.

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The ligand specificity of the alpha 3A beta 1 integrin was analyzed using K562 cells transfected with full-length alpha 3A cDNA and was compared with that of alpha 6A beta 1 in similarly transfected K562 cells. Clones were obtained that showed comparable surface expression of either alpha 3A beta 1 or alpha 6A beta 1 integrins. Those expressing alpha 3A beta 1 attached to and spread on immunopurified human kalinin and cellular matrices containing human kalinin, which is a particular isoform of laminin. In addition, alpha 3A transfectants adhered to bovine kidney laminins possessing a novel A c
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Hirosaki, Tomomi, Yoshiaki Tsubota, Yoshinobu Kariya, Kayano Moriyama, Hiroto Mizushima, and Kaoru Miyazaki. "Laminin-6 Is Activated by Proteolytic Processing and Regulates Cellular Adhesion and Migration Differently from Laminin-5." Journal of Biological Chemistry 277, no. 51 (2002): 49287–95. http://dx.doi.org/10.1074/jbc.m111096200.

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Laminin-6 (LN6) and laminin-5 (LN5), which share the common integrin-binding domain in the laminin α3 chain, are thought to cooperatively regulate cellular functions, but the former has poorly been characterized. Human fibrosarcoma HT1080 cells expressing an exogenous α3 chain were found to secrete LN6 with the full-length α3 chain and a smaller amount of its processed form lacking the carboxyl-terminal G4-5 domain, besides mature LN5 without G4-5 (mat-LN5). We prepared the unprocessed LN6 and mat-LN5, as well as LN6 mutants without G4-5 (LN6ΔG4-5) or G5 (LN6ΔG5). These laminins supported atta
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Lampe, Paul D., Beth P. Nguyen, Susana Gil та ін. "Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional Communication". Journal of Cell Biology 143, № 6 (1998): 1735–47. http://dx.doi.org/10.1083/jcb.143.6.1735.

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Wounding of skin activates epidermal cell migration over exposed dermal collagen and fibronectin and over laminin 5 secreted into the provisional basement membrane. Gap junctional intercellular communication (GJIC) has been proposed to integrate the individual motile cells into a synchronized colony. We found that outgrowths of human keratinocytes in wounds or epibole cultures display parallel changes in the expression of laminin 5, integrin α3β1, E-cadherin, and the gap junctional protein connexin 43. Adhesion of keratinocytes on laminin 5, collagen, and fibronectin was found to differentiall
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Ogawa, Takashi, Yoshiaki Tsubota, Junko Hashimoto, Yoshinobu Kariya та Kaoru Miyazaki. "The Short Arm of Laminin γ2 Chain of Laminin-5 (Laminin-332) Binds Syndecan-1 and Regulates Cellular Adhesion and Migration by Suppressing Phosphorylation of Integrin β4 Chain". Molecular Biology of the Cell 18, № 5 (2007): 1621–33. http://dx.doi.org/10.1091/mbc.e06-09-0806.

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The proteolytic processing of laminin-5 at the short arm of the γ2 chain (γ2sa) is known to convert this laminin from a cell adhesion type to a motility type. Here, we studied this mechanism by analyzing the functions of γ2sa. In some immortalized or tumorigenic human cell lines, a recombinant γ2sa, in either soluble or insoluble (coated) form, promoted the adhesion of these cells to the processed laminin-5 (Pr-LN5), and it suppressed their migration stimulated by serum or epidermal growth factor (EGF). γ2sa also suppressed EGF-induced tyrosine phosphorylation of integrin β4 and resultant disr
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Kiyozumi, Daiji, Yukimasa Taniguchi, Itsuko Nakano та ін. "Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality". Life Science Alliance 1, № 5 (2018): e201800064. http://dx.doi.org/10.26508/lsa.201800064.

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Laminin–integrin interactions regulate various adhesion-dependent cellular processes. γ1C-Glu, the Glu residue in the laminin γ1 chain C-terminal tail, is crucial for the binding of γ1-laminins to several integrin isoforms. Here, we investigated the impact of γ1C Glu to Gln mutation on γ1-laminin binding to all possible integrin partners in vitro, and found that the mutation specifically ablated binding to α3, α6, and α7 integrins. To examine the physiological significance of γ1C-Glu, we generated a knock-in allele, Lamc1EQ, in which the γ1C Glu to Gln mutation was introduced. Although Lamc1EQ
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Bartolucci, Pablo, Vicky Chaar, Julien Picot, et al. "Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation." Blood 116, no. 12 (2010): 2152–59. http://dx.doi.org/10.1182/blood-2009-12-257444.

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Abstract Sickle cell disease is characterized by painful vaso-occlusive crises during which abnormal interactions between erythroid adhesion molecules and vessel-wall proteins are thought to play a critical role. Hydroxyurea, the only drug with proven benefit in sickle cell disease, diminishes these interactions, but its mechanism of action is not fully understood. We report that, under hydroxyurea, expression of the unique erythroid laminin receptor Lu/BCAM was increased, but red blood cell adhesion to laminin decreased. Because Lu/BCAM phosphorylation is known to activate cell adhesion to la
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Ryan, Maureen C., Keesook Lee, Yuko Miyashita, and William G. Carter. "Targeted Disruption of the LAMA3 Gene in Mice Reveals Abnormalities in Survival and Late Stage Differentiation of Epithelial Cells." Journal of Cell Biology 145, no. 6 (1999): 1309–24. http://dx.doi.org/10.1083/jcb.145.6.1309.

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Laminin 5 regulates anchorage and motility of epithelial cells through integrins α6β4 and α3β1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the α3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all α3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhe
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Dissertations / Theses on the topic "Laminin cellular adhesion"

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Newsome, Laura Jean. "Global Gene Expression Profiles and Proteomic Assessments in Adult Females with Obstructive Sleep Apnea Syndrome." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77306.

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Obstructive sleep apnea syndrome (OSAS) is a complex disorder characterized by repetitive bouts of upper airway collapse during sleep, causing subsequent intermittent hypoxia, hypercapnia, and fragmented sleep and is also associated with significant morbidity including daytime sleepiness, hypertension, and elevated cardiovascular risk. OSAS affects at least 4% of men and 2% of women; unfortunately, it is estimated that 80% to 90% of adults with OSAS remain undiagnosed. Both clinical characteristics and complex genetic and environmental interactions have made it difficult to understand OSAS dis
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Carulli, Sonia. "Molecular basis of syndecan-1 mediated cell adhesion to laminin 332." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10134.

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L’interaction du récepteur syndecan-1 de la famille des héparanes sulfates protéoglycanes avec le fragment carboxy-terminal alpha3LG4/5 de la protéine d’adhérence matricielle, la laminine 332, induit une réorganisation du cytosquelette de la cellule conduisant à la formation de filopodes et de microspicules, caractéristiques de la migration cellulaire. Notre laboratoire a mis en évidence que l’adhésion cellulaire syndecan-1 dépendante implique les chaînes d’héparanes sulfates et chondroïtine sulfate. Afin d’identifier le (les) zone(s) impliquée(s) dans l’interaction domaine LG4/5-syndécan-1, u
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Roche, Patricia. "Interactions des ostéoprogéniteurs avec les matrices extracellulaires : rôle des laminines." Lyon 1, 1998. http://www.theses.fr/1998LYO1T188.

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Decline-Grazian, Françoise. "Effet du TGF-β1 sur les interactions entre les kératinocytes et la laminine 5 : implication potentielle au cours de la cicatrisation cutanée". Lyon 1, 2000. http://www.theses.fr/2000LYO1T164.

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Lefrançois, Louise. "Etude des adhésines HBHA et LBP impliquées dans l'interaction de Mycobacterium avium ssp. paratuberculosis avec les cellules épithéliales intestinales, cibles privilégiées de la bactérie in vivo." Thesis, Tours, 2012. http://www.theses.fr/2012TOUR4020/document.

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Mycobacterium avium ssp. paratuberculosis (Map), agent étiologique de la paratuberculose, a évolué en deuxtypes dénommés, S pour« Sheep » et C pour « Cattle ». L’intestin grêle est le site primaire de l’infection à Map mais les mécanismes moléculaires impliqués dans l’implantation du bacille restent largement méconnus. L’objectif de mon projet de thèse visait à identifier et caractériser les adhésines exprimées par Map par des approches génétiques et biochimiques. J’ai ainsi purifié la HBHA et la LBP par chromatographie d’affinité puis les ai identifiés en spectrométrie de masse. L’originalité
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Onochie, Obianamma. "Alterations in basal lamina stiffness and focal adhesion turnover affect epithelial dynamics during corneal wound healing." Thesis, 2018. https://hdl.handle.net/2144/29992.

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Epithelial wound healing is essential for maintaining the function and clarity of the cornea. Successful repair after injury involves the coordinated movements of cell sheets over the wounded region. While collective migration has been the focus of many studies, the effects that environmental changes have on this form of movement are poorly understood. In certain pathologies where the cornea exists in a chronic hypoxic state, wound healing is delayed. The goal of this work is to examine the changes in corneal structure in hypoxic corneas that may affect migration and to determine the effects t
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Conference papers on the topic "Laminin cellular adhesion"

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Sundararaghavan, Harini G., Gary A. Monteiro, and David I. Shreiber. "Guided Axon Growth by Gradients of Adhesion in Collagen Gels." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-69124.

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During development, neurites are directed by gradients of attractive and repulsive soluble (chemotactic) cues and substrate-bound adhesive (haptotactic) cues. Many of these cues have been extensively researched in vitro, and incorporated into strategies for nerve and spinal cord regeneration, primarily to improve the regenerative environment. To enhance and direct growth, we have developed a system to create 1D gradients of adhesion through a 3D collagen gel using microfluidics. We test our system using collagen grafted with bioactive peptide sequences, IKVAV and YIGSR, from laminin — an extra
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Sundararaghavan, Harini G., Gary A. Monteiro, and David I. Shreiber. "Microfluidic Generation of Adhesion Gradients Through 3D Collagen Gels: Implications for Neural Tissue Engineering." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192987.

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During development, neurites are directed by gradients of attractive and repulsive soluble (chemotactic) cues and substrate-bound adhesive (haptotactic) cues. Many of these cues have been extensively researched in vitro, and incorporated into strategies for nerve and spinal cord regeneration, primarily to improve the regenerative environment. To enhance and direct growth, we have developed a system to create 1D gradients of adhesion through a 3D collagen gel using microfluidics. We test our system using collagen grafted with bioactive peptide sequences, IKVAV and YIGSR, from laminin — an extra
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Wasi, S., S. Juodvalkis, P. Alles, and J. E. Aubin. "STUDIES ON THE DIRECT PROTEOLYTIC ACTION OF HUMAN TISSUE PLASMINOGEN ACTIVATOR ON HUMAN FIBRONECTIN AND VITRONECTIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644376.

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The ability of cells to make or break specific attachments to extracellular matrix (ECM) and other cells is important in cell migration, proliferation and wound repair. Specific attachment proteins believed to be involved in mediating these interactions comprise functional domains joined by protease sensitive segments. Proteases can conceivably modulate cellular interactions by releasing functional domains from parent molecules. Tissue plasminogen activator (t-pA) is known to participate in various pathophysiological processes. That t-pA may also act directly on structural proteins has not bee
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