Log in

Relevant bibliographies by topics / Laminine / Journal articles

To see the other types of publications on this topic, follow the link: Laminine.

Journal articles on the topic 'Laminine'

Author: Grafiati

Published: 4 June 2021

Last updated: 22 June 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Laminine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dreyfus, JC. "Laminine et cancer." médecine/sciences 4, no. 2 (1988): 120. http://dx.doi.org/10.4267/10608/3780.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Fülöp, Tamas, Marie-Paule Jacob, Jean Wallach, et al. "Le récepteur de l’élastine-laminine." Journal de la Société de Biologie 195, no. 2 (2001): 157–64. http://dx.doi.org/10.1051/jbio/2001195020157.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Rousselle, Patricia. "Laminine 5, migration cellulaire et cancer." médecine/sciences 18, no. 10 (2002): 989–94. http://dx.doi.org/10.1051/medsci/20021810989.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Miner, Jeffrey H., Jeanette Cunningham та Joshua R. Sanes. "Roles for Laminin in Embryogenesis: Exencephaly, Syndactyly, and Placentopathy in Mice Lacking the Laminin α5 Chain". Journal of Cell Biology 143, № 6 (1998): 1713–23. http://dx.doi.org/10.1083/jcb.143.6.1713.

Full text

Abstract:

Laminins are the major noncollagenous glycoproteins of all basal laminae (BLs). They are α/β/γ heterotrimers assembled from 10 known chains, and they subserve both structural and signaling roles. Previously described mutations in laminin chain genes result in diverse disorders that are manifested postnatally and therefore provide little insight into laminin's roles in embryonic development. Here, we show that the laminin α5 chain is required during embryogenesis. The α5 chain is present in virtually all BLs of early somite stage embryos and then becomes restricted to specific BLs as developmen

APA, Harvard, Vancouver, ISO, and other styles

5

Daémi, N., T. Vallet, MF Jacquier, and L. Rémy. "Laminine, intégrines, organisation et comportement invasif des adénocarcinomes." médecine/sciences 10, no. 12 (1994): 1275. http://dx.doi.org/10.4267/10608/2566.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Louadah, B. "Expression de la laminine-5 par les cellules épithéliales alvéolaires." Revue des Maladies Respiratoires 21, no. 6 (2004): 1210. http://dx.doi.org/10.1016/s0761-8425(04)71615-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Girard, J., C. Marion, M. Liutkus, et al. "Hypotensive Constituents of Marine Algae; 1. Pharmacological Studies of Laminine." Planta Medica 54, no. 03 (1988): 193–96. http://dx.doi.org/10.1055/s-2006-962401.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Jivkov, I., A. Méchine-Neuville, S. Robine та ін. "Tumorigenèse induite sur des souris surexprimant la chaîne δ1 de laminine". Gastroentérologie Clinique et Biologique 30, № 5 (2006): 699. http://dx.doi.org/10.1016/s0399-8320(06)73266-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Floreani, A., M. Plebani, T. Bertin, D. Faggian, and M. Chiaramonte. "Type III procollagen peptide and laminine in primary biliary cirrhosis (PBC)." Journal of Hepatology 9 (January 1989): S150. http://dx.doi.org/10.1016/0168-8278(89)90475-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Lv, Xiuwen, Caifeng Bi, Yuhua Fan, Xia Zhang, Nan Zhang, and Pengfei Zhang. "Synthesis, Characterization and Antitumor Activity of Novel Cadmium Complex with Laminine Ligand." Asian Journal of Chemistry 27, no. 1 (2015): 224–28. http://dx.doi.org/10.14233/ajchem.2015.16879.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Genet, Jean Pierre, Serge Thorimbert, Sergio Mallart, and Nathalie Kardos. "A Short Route to (±)-N-Hydroxylysine and (±)-Laminine by Palladium-Catalyzed Reactions." Synthesis 1993, no. 03 (1993): 321–24. http://dx.doi.org/10.1055/s-1993-25858.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Rousselle, P., D. Pin, H. Chajra, and B. Herbage. "Propriétés cicatrisantes du domaine de liaison aux syndécans dans la laminine 332." Annales de Dermatologie et de Vénéréologie 140, no. 12 (2013): S633. http://dx.doi.org/10.1016/j.annder.2013.09.579.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Gu, Yuchen, Lydia Sorokin, Madeleine Durbeej, Tord Hjalt, Jan-Ingvar Jönsson, and Marja Ekblom. "Characterization of Bone Marrow Laminins and Identification of 5-Containing Laminins as Adhesive Proteins for Multipotent Hematopoietic FDCP-Mix Cells." Blood 93, no. 8 (1999): 2533–42. http://dx.doi.org/10.1182/blood.v93.8.2533.

Full text

Abstract:

Abstract Laminins are extracellular matrix glycoproteins that influence the phenotype and functions of many types of cells. Laminins are heterotrimers composed of , β, and γ polypeptides. So far five , three β, and two γ polypeptide chains, and 11 variants of laminins have been proposed. Laminins interact in vitro with mature blood cells and malignant hematopoietic cells. Most studies have been performed with laminin-1 (1β1γ1), and its expression in bone marrow is unclear. Employing an antiserum reacting with most laminin isoforms, we found laminins widely expressed in mouse bone marrow. Ho

APA, Harvard, Vancouver, ISO, and other styles

14

Gu, Yuchen, Lydia Sorokin, Madeleine Durbeej, Tord Hjalt, Jan-Ingvar Jönsson, and Marja Ekblom. "Characterization of Bone Marrow Laminins and Identification of 5-Containing Laminins as Adhesive Proteins for Multipotent Hematopoietic FDCP-Mix Cells." Blood 93, no. 8 (1999): 2533–42. http://dx.doi.org/10.1182/blood.v93.8.2533.408k22_2533_2542.

Full text

Abstract:

Laminins are extracellular matrix glycoproteins that influence the phenotype and functions of many types of cells. Laminins are heterotrimers composed of , β, and γ polypeptides. So far five , three β, and two γ polypeptide chains, and 11 variants of laminins have been proposed. Laminins interact in vitro with mature blood cells and malignant hematopoietic cells. Most studies have been performed with laminin-1 (1β1γ1), and its expression in bone marrow is unclear. Employing an antiserum reacting with most laminin isoforms, we found laminins widely expressed in mouse bone marrow. However, no

APA, Harvard, Vancouver, ISO, and other styles

15

Patton, Bruce L., Jeffrey H. Miner, Arlene Y. Chiu, and Joshua R. Sanes. "Distribution and Function of Laminins in the Neuromuscular System of Developing, Adult, and Mutant Mice." Journal of Cell Biology 139, no. 6 (1997): 1507–21. http://dx.doi.org/10.1083/jcb.139.6.1507.

Full text

Abstract:

Laminins, heterotrimers of α, β, and γ chains, are prominent constituents of basal laminae (BLs) throughout the body. Previous studies have shown that laminins affect both myogenesis and synaptogenesis in skeletal muscle. Here we have studied the distribution of the 10 known laminin chains in muscle and peripheral nerve, and assayed the ability of several heterotrimers to affect the outgrowth of motor axons. We show that cultured muscle cells express four different α chains (α1, α2, α4, and α5), and that developing muscles incorporate all four into BLs. The portion of the muscle's BL that occu

APA, Harvard, Vancouver, ISO, and other styles

16

Labat-Robert, Jacqueline. "Sites cryptiques et matrikines : Effets cellulaires des peptides de fibronectine et de laminine." Journal de la Société de Biologie 197, no. 1 (2003): 45–51. http://dx.doi.org/10.1051/jbio/2003197010045.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Armanet, M., A. Wojtusciszyn, P. Morel, T. Berney, and D. Bosco. "P63 L’interleukine-1bêta augmente l’expression de la laminine-5 dans l’îlot pancréatique humain." Diabetes & Metabolism 34 (March 2008): H61. http://dx.doi.org/10.1016/s1262-3636(08)72975-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Haddad, N., E. Bourrat, F. Caux, S. Grootenboer-Mignot, M. Alexandre та C. Prost. "Pemphigoïde des muqueuses à laminine 332 dans une fratrie atteinte d’épidermolyse bulleuse jonctionnelle non Herlitz, avec mutations à l’état hétérozygote composite du gène codant la chaine β3 de la laminine 332". Annales de Dermatologie et de Vénéréologie 146, № 12 (2019): A94. http://dx.doi.org/10.1016/j.annder.2019.09.094.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Moutsita, R., J. Botti, MA Doyennette-Moyne, P. Codogno, and M. Aubery. "MISE EN EVIDENCE DE GLYCOPROTEINES MEMBRANAIRES IMPLIQUEES DANS L'ETALEMENT DES CELLULES SUR LA LAMININE." Reproduction Nutrition Développement 29, Suppl. 1 (1989): 37. http://dx.doi.org/10.1051/rnd:19890764.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Gu, Yu-Chen, Jarkko Kortesmaa, Karl Tryggvason, et al. "Laminin isoform–specific promotion of adhesion and migration of human bone marrow progenitor cells." Blood 101, no. 3 (2003): 877–85. http://dx.doi.org/10.1182/blood-2002-03-0796.

Full text

Abstract:

Abstract Laminins are αβγ heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing α4 and α5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. We studied human bone marrow cell adhesion to laminin-10/11 (α5β1γ1/α5β2γ1), laminin-8 (α4β1γ1), laminin-1 (α1β1γ1), and fibronectin. About 35% to 40% of CD34+ and CD34+CD38− stem and progenitor cells adhered to laminin-10/11, and 45% to 50% adhered to fibronectin, whereas they adhered less to laminin-8 and laminin-1

APA, Harvard, Vancouver, ISO, and other styles

21

Vainionpää, Noora, Yamato Kikkawa, Kari Lounatmaa, Jeffrey H. Miner, Patricia Rousselle, and Ismo Virtanen. "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells." American Journal of Physiology-Cell Physiology 290, no. 3 (2006): C764—C775. http://dx.doi.org/10.1152/ajpcell.00285.2005.

Full text

Abstract:

Laminin α5-chain, a constituent of laminins-10 and -11, is expressed in endothelial basement membranes. In this study we evaluated the roles of α5 laminins and Lutheran blood group glycoproteins (Lu), recently identified receptors of the laminin α5-chain, in the adhesion of human dermal microvascular and pulmonary artery endothelial cells. Field emission scanning electron microscopy and immunohistochemistry showed that the endothelial cells spread on laminin-10 and formed fibronectin-positive fibrillar adhesion structures. Immunoprecipitation results suggested that the cells produced fibronect

APA, Harvard, Vancouver, ISO, and other styles

22

Francoeur, Caroline, Fabrice Escaffit, Pierre H. Vachon та Jean-François Beaulieu. "Proinflammatory cytokines TNF-α and IFN-γ alter laminin expression under an apoptosis-independent mechanism in human intestinal epithelial cells". American Journal of Physiology-Gastrointestinal and Liver Physiology 287, № 3 (2004): G592—G598. http://dx.doi.org/10.1152/ajpgi.00535.2003.

Full text

Abstract:

Laminins are basement membrane molecules that mediate cell functions such as adhesion, proliferation, migration, and differentiation. In the normal small intestine, laminin-5 and -10 are mainly expressed at the base of villus cells. However, in Crohn's disease (CD), a major redistribution of these laminins to the crypt region of the inflamed ileal mucosa has been observed, suggesting a possible relationship between laminin expression and cytokine and/or growth factor production, which is also altered in CD. The aim of this study was to test the hypothesis that proinflammatory cytokines can mod

APA, Harvard, Vancouver, ISO, and other styles

23

Péterszegi, Gabriella. "Expression du récepteur de l'élastine-laminine sur les lymphocytes humains activés. Rôle possible dans l'athérogenèse." Journal de la Société de Biologie 193, no. 2 (1999): 229–30. http://dx.doi.org/10.1051/jbio/1999193020229.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Bernard Jaoul, A., and Z. Li. "D018 Etude de l’interaction entre le PEDF et le récepteur de la laminine 37LRP/67LR." Archives of Cardiovascular Diseases 102 (March 2009): S42. http://dx.doi.org/10.1016/s1875-2136(09)72228-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Bartolucci, P., V. Chaar, J. Picot, et al. "L’hydroxycarbamide diminue l’adhérence des globules rouges drépanocytaires à la laminine : description d’un nouveau mode d’action." La Revue de Médecine Interne 31 (December 2010): S361—S362. http://dx.doi.org/10.1016/j.revmed.2010.10.052.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Natsumi, Aki, Koji Sugawara, Makiko Yasumizu, et al. "Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?" Journal of Histochemistry & Cytochemistry 66, no. 12 (2018): 847–62. http://dx.doi.org/10.1369/0022155418782693.

Full text

Abstract:

Psoriasis is a complex chronic inflammatory skin disease characterized by epidermal thickening on the basis of increased keratinocyte proliferation and insufficient apoptosis. Laminins are important components of the basement membrane (BM) and impact on epidermal keratinocyte growth/apoptosis. Although several laminins are involved in the pathogenesis of psoriasis, it is still controversial about the expression patterns of laminin isoforms and which laminins are important in the development of psoriasis. Because laminin-511 and -332 are key BM components in human skin, and laminin-511 stimulat

APA, Harvard, Vancouver, ISO, and other styles

27

Nishimune, Hiroshi, Gregorio Valdez, George Jarad, et al. "Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction." Journal of Cell Biology 182, no. 6 (2008): 1201–15. http://dx.doi.org/10.1083/jcb.200805095.

Full text

Abstract:

A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich postsynaptic membrane from an ovoid plaque into a complex array of branches. We show here that laminins play an autocrine role in promoting this transformation. Laminins containing the α4, α5, and β2 subunits are synthesized by muscle fibers and concentrated in the small portion of the basal lamina that passes through the synaptic cleft at the NMJ. Topological maturation of AChR clusters was delayed in targeted mutant mice lacking laminin α5

APA, Harvard, Vancouver, ISO, and other styles

28

Seret, Guillaume, Yannick Le Meur, Yves Renaudineau, and Pierre Youinou. "Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis." Clinical and Developmental Immunology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/579670.

Full text

Abstract:

Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their

APA, Harvard, Vancouver, ISO, and other styles

29

Jiang, Fang-Xu, Gaetano Naselli, and Leonard C. Harrison. "Distinct Distribution of Laminin and Its Integrin Receptors in the Pancreas." Journal of Histochemistry & Cytochemistry 50, no. 12 (2002): 1625–32. http://dx.doi.org/10.1177/002215540205001206.

Full text

Abstract:

Tissue function is regulated by the extracellular microenvironment including cell basement membranes, in which laminins are a major component. Previously, we found that laminin-1 promotes differentiation and survival of pancreatic islet cells. Here we characterize the expression pattern of laminins and their integrin receptors in adult pancreas. Although they are expressed in the basement membrane of acinar cells and duct epithelium, no laminin chains examined were detected extracellularly in the pancreatic islets. In contrast to laminin β1- and γ1-chains, the α1-chain, unique to laminin-1, wa

APA, Harvard, Vancouver, ISO, and other styles

30

Champliaud, M. F., G. P. Lunstrum, P. Rousselle, T. Nishiyama, D. R. Keene, and R. E. Burgeson. "Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment." Journal of Cell Biology 132, no. 6 (1996): 1189–98. http://dx.doi.org/10.1083/jcb.132.6.1189.

Full text

Abstract:

Stable attachment of external epithelia to the basement membrane and underlying stroma is mediated by transmembrane proteins such as the integrin alpha6beta4 and bullous pemphigoid antigen 2 within the hemidesmosomes along the basolateral surface of the epithelial cell and their ligands that include a specialized subfamily of laminins. The laminin 5 molecule (previously termed kalinin/nicein/epiligrin) is a member of this epithelial-specific subfamily. Laminin 5 chains are not only considerably truncated within domains III-VI, but are also extensively proteolytically processed in vitro and in

APA, Harvard, Vancouver, ISO, and other styles

31

Sixt, Michael, Britta Engelhardt, Friederike Pausch, Rupert Hallmann, Olaf Wendler, and Lydia M. Sorokin. "Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis." Journal of Cell Biology 153, no. 5 (2001): 933–46. http://dx.doi.org/10.1083/jcb.153.5.933.

Full text

Abstract:

An active involvement of blood–brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extravasating T lymphocytes during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes contained laminin 8 (α4β1γ1) and/or 10 (α5β1γ1) and their expression was influenced by proinflammatory cytokines or angiostatic agents. T cells emigrating into the CNS during EAE encou

APA, Harvard, Vancouver, ISO, and other styles

32

Delwel, G. O., A. A. de Melker, F. Hogervorst, et al. "Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms." Molecular Biology of the Cell 5, no. 2 (1994): 203–15. http://dx.doi.org/10.1091/mbc.5.2.203.

Full text

Abstract:

The ligand specificity of the alpha 3A beta 1 integrin was analyzed using K562 cells transfected with full-length alpha 3A cDNA and was compared with that of alpha 6A beta 1 in similarly transfected K562 cells. Clones were obtained that showed comparable surface expression of either alpha 3A beta 1 or alpha 6A beta 1 integrins. Those expressing alpha 3A beta 1 attached to and spread on immunopurified human kalinin and cellular matrices containing human kalinin, which is a particular isoform of laminin. In addition, alpha 3A transfectants adhered to bovine kidney laminins possessing a novel A c

APA, Harvard, Vancouver, ISO, and other styles

33

Chartier, N., M. Lainé, C. Marie, M. Block, and M. Jacquier-Sarlin. "C6-Rôles de la laminine 5 dans la formation des jonctions adhérentes et la différenciation entérocytaire." Gastroentérologie Clinique et Biologique 30, no. 1 (2006): 73. http://dx.doi.org/10.1016/s0399-8320(06)73084-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

GENET, J. P., S. THORIMBERT, S. MALLART, and N. KARDOS. "ChemInform Abstract: A Short Route to (.+-.)-N-Hydroxylysine (I) and (.+-.)-Laminine (II) by Palladium-Catalyzed Reactions." ChemInform 24, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199339271.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Trewin, N. H., and R. G. Davidson. "An Early Devonian lake and its associated biota in the Midland Valley of Scotland." Transactions of the Royal Society of Edinburgh: Earth Sciences 86, no. 4 (1995): 233–46. http://dx.doi.org/10.1017/s0263593300007641.

Full text

Abstract:

ABSTRACTThe Tillywhandland fish bed of the Lower Old Red Sandstone in the Strathmore area of the Scottish Midland Valley accumulated in a lake, here called Lake Forfar, which was created suddenly following a period of fluvial deposition. Lake creation may have been due to basin faulting or the disruption of drainage patterns by contemporaneous volcanic activity. The fish bed laminites accumulated in a hydrologically open lake under a seasonal climatic regime. When fully developed, laminites comprise repeated quadruplets of clastic silt/carbonate/organic/green clay–shale laminae averaging 0·5 m

APA, Harvard, Vancouver, ISO, and other styles

36

Brandenberger, R., and M. Chiquet. "Distinct heparin-binding and neurite-promoting properties of laminin isoforms isolated from chick heart." Journal of Cell Science 108, no. 9 (1995): 3099–108. http://dx.doi.org/10.1242/jcs.108.9.3099.

Full text

Abstract:

Laminin isolated from chick heart is composed of several heterotrimeric variants of 800 and 700 kDa. Here, we used monoclonal antibodies against chick laminin to purify different laminin isoforms from this mixture. Antibody 8D3 specifically removed laminin containing alpha 2 chain from chick heart laminin preparations, leaving behind 700 kDa variants. Using antibody C4 against the laminin beta 2 chain, alpha 2 chain containing variants were further separated into alpha 2 beta 1 gamma 1 and alpha 2 beta 2 gamma 1 laminin, respectively. Laminins containing alpha 2 chain and recognized by antibod

APA, Harvard, Vancouver, ISO, and other styles

37

Teller, Inga C., and Jean-François Beaulieu. "Interactions between laminin and epithelial cells in intestinal health and disease." Expert Reviews in Molecular Medicine 3, no. 24 (2001): 1–18. http://dx.doi.org/10.1017/s1462399401003623.

Full text

Abstract:

Laminins are a multigene family of extracellular matrix molecules. Quantitatively, they are one of the most abundant glycoproteins present in basement membranes. Functionally, they can modulate several key biological activities, including cell adhesion and migration, gene expression and cell survival. Variability in the spatial and temporal expression of laminins, as well as of their specific receptors of the integrin family, in various tissues and organs, suggests that different laminins perform distinct functions. This article focuses on the human intestinal epithelium as a paradigm to illus

APA, Harvard, Vancouver, ISO, and other styles

38

Schuger, Lucia, Amy P. N. Skubitz, Jun Zhang, Lydia Sorokin та Li He. "Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development". Journal of Cell Biology 139, № 2 (1997): 553–62. http://dx.doi.org/10.1083/jcb.139.2.553.

Full text

Abstract:

Laminins, the main components of basement membranes, are heterotrimers consisting of α, β, and γ polypeptide chains linked together by disulfide bonds. Laminins-1 and -2 are both composed of β1 and γ1 chains and differ from each other on their α chain, which is α1 and α2 for laminin-1 and -2, respectively. The present study shows that whereas laminins-1 and -2 are synthesized in the mouse developing lung and in epithelial–mesenchymal cocultures derived from it, epithelial and mesenchymal monocultures lose their ability to synthesize the laminin α1 chain. Synthesis of laminin α1 chain however r

APA, Harvard, Vancouver, ISO, and other styles

39

Gersdorff, Nikolaus, Eddie Kohfeldt, Takako Sasaki, Rupert Timpl та Nicolai Miosge. "Laminin γ3 Chain Binds to Nidogen and Is Located in Murine Basement Membranes". Journal of Biological Chemistry 280, № 23 (2005): 22146–53. http://dx.doi.org/10.1074/jbc.m501875200.

Full text

Abstract:

Recently a novel laminin γ3 chain was identified in mouse and human and shown to have the same modular structure as the laminin γ1 chain. We expressed two fragments of the γ3 chain in mammalian cells recombinantly. The first, domain VI/V, consisting of laminin N-terminal (domain VI) and four laminin-type epidermal growth factor-like (domain V) and laminin N-terminal modules, was shown to be essential for self-assembly of laminins. The other was domain III3–5, which consists of three laminin-type epidermal growth factor-like modules and is predicted to bind to nidogens. The γ3 VI/V fragment was

APA, Harvard, Vancouver, ISO, and other styles

40

Greciano, Patricia G., Jose V. Moyano, Mary M. Buschmann, et al. "Laminin 511 partners with laminin 332 to mediate directional migration of Madin–Darby canine kidney epithelial cells." Molecular Biology of the Cell 23, no. 1 (2012): 121–36. http://dx.doi.org/10.1091/mbc.e11-08-0718.

Full text

Abstract:

Sustained directional migration of epithelial cells is essential for regeneration of injured epithelia. Front–rear polarity of migrating cells is determined by local activation of a signaling network involving Cdc42 and other factors in response to spatial cues from the environment, the nature of which are obscure. We examined the roles of laminin (LM)-511 and LM-332, two structurally different laminin isoforms, in the migration of Madin–Darby canine kidney cells by suppressing expression of their α subunits using RNA interference. We determined that knockdown of LM-511 inhibits directional mi

APA, Harvard, Vancouver, ISO, and other styles

41

Knyazev, E. N., D. V. Maltseva, D. A. Sakharov, and T. N. Gerasimenko. "Use of Impedance Spectroscopy to Assess the Effect of Laminins on the in vitro Differentiation of Intestinal Cells." Biotekhnologiya 35, no. 6 (2019): 102–7. http://dx.doi.org/10.21519/0234-2758-2019-35-6-102-107.

Full text

Abstract:

The comparative analysis of electrical parameters of a Caco-2 cell monolayer cultured on substrates coated with laminins 111,332и511 has been carried out. The cell electrical parameters reflect its state and, in particular, its degree of differentiation. Impedance spectroscopy is the most convenient method for comprehensive assessment of electrical parameters. It was shown via this method that laminin 332 was the optimal substrate for CACO-2 cell growth and differentiation in vitro. The use of laminin 511 led to significantly lower electric capacitance, and laminin 111 caused a large increase

APA, Harvard, Vancouver, ISO, and other styles

42

Nigatu, Ayele, Wondossen Sime, Gezahegn Gorfu та ін. "Megakaryocytic cells synthesize and platelets secrete α5-laminins, and the endothelial laminin isoform laminin 10 (α5β1γ1) strongly promotes adhesion but not activation of platelets". Thrombosis and Haemostasis 95, № 01 (2006): 85–93. http://dx.doi.org/10.1160/th05-04-0281.

Full text

Abstract:

SummaryFollowing vascular injury, basement membrane (BM) components of the blood vessels are exposed to circulating cells and may contribute to hemostasis and/or thrombosis. Laminins 8 (LN-8) (α4β1γ1) and 10 (LN-10) (α5β1γ1) are major laminin isoforms of the endothelial BM, and LN-8 is also secreted by activated platelets. In the present study, we demonstrate synthesis of α5-laminins LN-10 and LN-11 (α5β2γ1) by megakaryocytic cells, and intracellular expression of these laminin isoforms in blood platelets. In contrast to platelet LNα4 chain that had an apparent molecular weight of 180 kDa and

APA, Harvard, Vancouver, ISO, and other styles

43

Ferletta, Maria, Yamato Kikkawa, Hao Yu та ін. "Opposing Roles of Integrin α6Aβ1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation". Molecular Biology of the Cell 14, № 5 (2003): 2088–103. http://dx.doi.org/10.1091/mbc.e03-01-0852.

Full text

Abstract:

Laminin–integrin interactions can in some settings activate the extracellular signal-regulated kinases (ERKs) but the control mechanisms are poorly understood. Herein, we studied ERK activation in response to two laminins isoforms (-1 and -10/11) in two epithelial cell lines. Both cell lines expressed β1-containing integrins and dystroglycan but lacked integrin α6β4. Antibody perturbation assays showed that both cell lines bound to laminin-10/11 via the α3β1and α6β1 integrins. Although laminin-10/11 was a stronger adhesion complex than laminin-1 for both cell lines, both laminins activated ERK

APA, Harvard, Vancouver, ISO, and other styles

44

Miner, Jeffrey H., Bruce L. Patton, Stephen I. Lentz та ін. "The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform". Journal of Cell Biology 137, № 3 (1997): 685–701. http://dx.doi.org/10.1083/jcb.137.3.685.

Full text

Abstract:

Laminin trimers composed of α, β, and γ chains are major components of basal laminae (BLs) throughout the body. To date, three α chains (α1–3) have been shown to assemble into at least seven heterotrimers (called laminins 1–7). Genes encoding two additional α chains (α4 and α5) have been cloned, but little is known about their expression, and their protein products have not been identified. Here we generated antisera to recombinant α4 and α5 and used them to identify authentic proteins in tissue extracts. Immunoprecipitation and immunoblotting showed that α4 and α5 assemble into four novel lam

APA, Harvard, Vancouver, ISO, and other styles

45

Ferletta, M., and P. Ekblom. "Identification of laminin-10/11 as a strong cell adhesive complex for a normal and a malignant human epithelial cell line." Journal of Cell Science 112, no. 1 (1999): 1–10. http://dx.doi.org/10.1242/jcs.112.1.1.

Full text

Abstract:

Laminins are heterotrimeric proteins of basement membranes. More than 50 different trimers may exist. Laminin-10 (alpha5beta1gamma1 rather than laminin-1 (alpha1beta1gamma1) could be the most abundant isoform in the adult stage, and laminin-10 is made by several developing epithelial sheets. We show here that a much used commercial human preparation contains laminin-10 (alpha5beta1gamma1), some laminin-11 (alpha5beta2gamma1), but no laminin-1. Moreover, the laminin-10/11 mixture was found to be a strong adhesive for two human cell lines derived from epithelia. Antibodies against integrin beta1

APA, Harvard, Vancouver, ISO, and other styles

46

Altera, Annalisa, Gian Marco Tosi, Marì Regoli, Elena De Benedetto, and Eugenio Bertelli. "The extracellular matrix complexity of idiopathic epiretinal membranes and the bilaminar arrangement of the associated internal limiting membrane in the posterior retina." Graefe's Archive for Clinical and Experimental Ophthalmology 259, no. 9 (2021): 2559–71. http://dx.doi.org/10.1007/s00417-021-05156-6.

Full text

Abstract:

Abstract Purpose To study the composition of the internal limiting membrane (ILM) of the retina, the extracellular matrix (ECM) of idiopathic epiretinal membranes (iERMs), and the relationships occurring between the two membranes. Methods Forty-six iERMs, 24 of them associated with the ILM, were collected and included in this study. The investigation has been carried out by immunofluorescence and confocal microscopy on glutaraldehyde- and osmium-fixed epon-embedded samples and on frozen samples. Sections were double or triple labelled with antibodies against vimentin; collagens I, III, IV, α5(

APA, Harvard, Vancouver, ISO, and other styles

47

Hohenester, Erhard. "Structural biology of laminins." Essays in Biochemistry 63, no. 3 (2019): 285–95. http://dx.doi.org/10.1042/ebc20180075.

Full text

Abstract:

Abstract Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains. Crystallographic studies since the mid-1990s have added atomic detail to all parts of the laminin heterotrimer. The three short arms of the cross are made up of continuous arrays of disulphide-rich domains. The globular domains at the tips of the short arms mediate laminin polymeriza

APA, Harvard, Vancouver, ISO, and other styles

48

Wondimu, Zenebech, Tarekegn Geberhiwot, Sulev Ingerpuu та ін. "An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis". Blood 104, № 6 (2004): 1859–66. http://dx.doi.org/10.1182/blood-2004-01-0396.

Full text

Abstract:

Abstract During extravasation, neutrophils migrate through the perivascular basement membrane (BM), a specialized extracellular matrix rich in laminins. Laminins 8 (LN-8) (α4β1γ1) and 10 (LN-10) (α5β1γ1) are major components of the endothelial BM, but expression, recognition, and use of these laminin isoforms by neutrophils are poorly understood. In the present study, we provide evidence, using a panel of novel monoclonal antibodies against human laminin α4 (LNα4) chain, that neutrophils contain and secrete LN-8, and that this endogenous laminin contributes to chemoattractant-induced, αMβ2-int

APA, Harvard, Vancouver, ISO, and other styles

49

Rousselle, Patricia, Douglas R. Keene, Florence Ruggiero, Marie-France Champliaud, Michel van der Rest, and Robert E. Burgeson. "Laminin 5 Binds the NC-1 Domain of Type VII Collagen." Journal of Cell Biology 138, no. 3 (1997): 719–28. http://dx.doi.org/10.1083/jcb.138.3.719.

Full text

Abstract:

Mutational analyses of genes that encode components of the anchoring complex underlying the basolateral surface of external epithelia indicate that this structure is the major element providing for resistance to external friction. Ultrastructurally, laminin 5 (α3β3γ2; a component of the anchoring filament) appears as a thin filament bridging the hemidesmosome with the anchoring fibrils. Laminin 5 binds the cell surface through hemidesmosomal integrin α6β4. However, the interaction of laminin 5 with the anchoring fibril (type VII collagen) has not been elucidated. In this study we demonstrate t

APA, Harvard, Vancouver, ISO, and other styles

50

Silva, Eline Manhães Reid, Letícia Côgo Marques, Kristian Cláudio Callegari, and Letícia Nogueira da Gama de Souza. "Avaliação da laminina-332 na tumorigênese de carcinoma de células escamosas orais: uma revisão de literatura." Revistas 74, no. 1 (2017): 56. http://dx.doi.org/10.18363/rbo.v74n1.p.56.

Full text

Abstract:

Objetivo: verificar se a laminina-332 é um marcador de alterações em processos iniciais da carcinogênese. Material e Métodos: trata-se de uma revisão da literatura, realizada a partir da seleção e análise de artigos originais e de revisão, publicados entre os anos de 1997 a 2013 no portal eletrônico Pubmed, Academic Google e portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Resultados: foram selecionados 36 artigos através dos descritores: “oral”; “squamous cell carcinoma”; “laminin-332 ou laminin-5”, “oral dysplastic cells” “potentially malignant dis

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!