Academic literature on the topic 'Langendorff perfusion'

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Journal articles on the topic "Langendorff perfusion"

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Nakamura, Yuji, Kentaro Ando, and Atsushi Sugiyama. "Langendorff perfusion heart model." Folia Pharmacologica Japonica 140, no. 4 (2012): 166–69. http://dx.doi.org/10.1254/fpj.140.166.

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Bell, Robert M., Mihaela M. Mocanu, and Derek M. Yellon. "Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion." Journal of Molecular and Cellular Cardiology 50, no. 6 (2011): 940–50. http://dx.doi.org/10.1016/j.yjmcc.2011.02.018.

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Ashruf, J. F., C. Ince, and H. A. Bruining. "Regional ischemia in hypertrophic Langendorff-perfused rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 4 (1999): H1532—H1539. http://dx.doi.org/10.1152/ajpheart.1999.277.4.h1532.

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Myocardial hypertrophy decreases the muscle mass-to-vascularization ratio, thereby changing myocardial perfusion. The effect of these changes on myocardial oxygenation in hypertrophic Langendorff-perfused rat hearts was measured using epimyocardial NADH videofluorimetry, whereby ischemic myocardium displays a high fluorescence intensity. Hypertrophic hearts, in contrast to control hearts, developed ischemic areas during oxygen-saturated Langendorff perfusion. Reoxygenation of control hearts after a hypoxic episode resulted in a swift decrease of fluorescence in a heterogeneous pattern of small
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Pelgrim, Gert Jan, Marco Das, Ulrike Haberland, et al. "Development of anEx Vivo, Beating Heart Model for CT Myocardial Perfusion." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/412716.

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Objective. To test the feasibility of a CT-compatible,ex vivo, perfused porcine heart model for myocardial perfusion CT imaging.Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0.Results. CT i
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Li, Haotong, Chungeng Liu, Minghui Bao, et al. "Optimized Langendorff perfusion system for cardiomyocyte isolation in adult mouse heart." Journal of Cellular and Molecular Medicine 24, no. 24 (2020): 14619–25. http://dx.doi.org/10.1111/jcmm.15773.

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Wiechert, S., A. El-Armouche, T. Rau, W. H. Zimmermann, and T. Eschenhagen. "24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer." American Journal of Physiology-Heart and Circulatory Physiology 285, no. 2 (2003): H907—H914. http://dx.doi.org/10.1152/ajpheart.00856.2002.

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The human genome project has increased the demand for simple experimental systems that allow the impact of gene manipulations to be studied under controlled ex vivo conditions. We hypothesized that, in contrast to adult hearts, neonatal hearts allow long-term perfusion and efficient gene transfer ex vivo. A Langendorff perfusion system was modified to allow perfusion for >24 h with particular emphasis on uncompromised contractile activity, sterility, online measurement of force of contraction, inotropic response to β-adrenergic stimulation, and efficient gene transfer. The hearts were perfu
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Fitt, Peter S., Borivoj Korecky, and Nishi Sharma. "A possible adenine nucleotide storage form in normal and ischaemic rat heart." Bioscience Reports 5, no. 1 (1985): 7–12. http://dx.doi.org/10.1007/bf01117435.

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Perfusion of Langendorff rat hearts with [14C]adenosine yields an acid-insoluble, radioactive product whose concentration falls during ischaemia. The properties of the substance show that it is a polyribonucleotide. It is suggested that it may be mitochondrial poly A acting as a storage form of adenine nucleotides.
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Skrzypiec-Spring, Monika, Bartosz Grotthus, Adam Szeląg, and Richard Schulz. "Isolated heart perfusion according to Langendorff—Still viable in the new millennium." Journal of Pharmacological and Toxicological Methods 55, no. 2 (2007): 113–26. http://dx.doi.org/10.1016/j.vascn.2006.05.006.

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Zimmer, Heinz-Gerd. "The Isolated Perfused Heart and Its Pioneers." Physiology 13, no. 4 (1998): 203–10. http://dx.doi.org/10.1152/physiologyonline.1998.13.4.203.

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In 1866, Carl Ludwig together with Elias Cyon created the first isolated perfused frog heart preparation. Perfusion systems for the isolated mammalian heart were developed by H. Newell Martin in 1883 and by Oscar Langendorff in 1895. In its working mode, the isolated perfused rat heart was established in the 1960s.
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Southworth, R., S. C. Blackburn, K. A. B. Davey, G. K. Sharland, and P. B. Garlick. "The low oxygen-carrying capacity of Krebs buffer causes a doubling in ventricular wall thickness in the isolated heart." Canadian Journal of Physiology and Pharmacology 83, no. 2 (2005): 174–82. http://dx.doi.org/10.1139/y04-138.

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The buffer-perfused Langendorff heart is significantly vasodilated compared with the in vivo heart. In this study, we employed ultrasound to determine if this vasodilation translated into changes in left ventricular wall thickness (LVWT), and if this effect persisted when these hearts were switched to the "working" mode. To investigate the effects of perfusion pressure, vascular tone, and oxygen availability on cardiac dimensions, we perfused hearts (from male Wistar rats) in the Langendorff mode at 80, 60, and 40 cm H2O pressure, and infused further groups of hearts with either the vasoconstr
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Dissertations / Theses on the topic "Langendorff perfusion"

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Stebal, Cory J. "Isoform Specific Effect of Ischemia/Reperfusion on Cardiac Na,K-ATPase: Protection by Ouabain Preconditioning." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1243946706.

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Yi, Xiaoqin. "Total ginsenosides of Asian ginseng increase coronary artery perfusion flow of the ischemia-reperfusion injury rat heart in Langendorff system through activation of Akt-eNOS signaling and cardiac energy-associate protein expression." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1195.

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Novotná, Petra. "Analýza vysokofrekvenčních EKG signálů a mechano-elektrické vazby u izolovaného srdce." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-316809.

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Tato magisterská práce se zabývá analýzou vysokofrekvenčních složek záznamu EKG z pohledu mechano-elektrické vazby u izolovaného králičího srdce. První částí této práce je literární rešerše na zadané téma zahrnující informace o vzniku a šíření akčního potenciálu na chemické i elektrické úrovní i mechano-elektrické zpětné vazbě. Dále práce obsahuje kapitolu zabývající se tématikou průměrování signálu jako techniky ke zvýšení poměru signál-šum při analýze vysokofrekvenčních složek. V praktické části práce jsou získané poznatky aplikovány na dlouhé záznamy EKG z izolovaných králičích srdcí. Zahrn
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Hornung, Daniel. "Cardiac Arrhythmia Termination on the Vascular and Organ Scale." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0023-9934-8.

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Book chapters on the topic "Langendorff perfusion"

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Watanabe, Makino, and Takao Okada. "Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8597-5_8.

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Conference papers on the topic "Langendorff perfusion"

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Selby, Ryan Wade, Anup Jonchhe, Chen Kaplan, Coeli M. Lopes, and Behnaz Ghoraani. "Development of data acquisition components for simultaneous recording of 3D epicardial and surface ECG signals in the langendorff perfusion apparatus." In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2016. http://dx.doi.org/10.1109/embc.2016.7591295.

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Giannessi, D., R. De Caterina, G. Lazzerini, R. Sicari, and P. Gazzetti. "RELATIVE SENSITIVITY OF CARDIAC PROSTACYCLIN AND THROMBOXANE TO INHIBITION BY NON-STEROIDAL ANTIINFLAMMATORY DRUGS IN THE RAT HEART." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643390.

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We have previously shown that the isolated perfused rat Langendorff heart is able to synthesize detectable amounts of thromboxane (TX) A2, as well as prostacyclin (PGI2). Eicosanoid production in this system is increased during post-ischemic reperfusion, reflecting greater availability of substrate and net increase of synthesis. We assessed relative sensitivity of cyclooxygenases synthesizing TX and prostacyclin (probably located in different cell types) to aspirin (0.1, 0.5, 1 g/1), ibuprofen (1, 10, 80, 160, 320 mg/1) and diclofenac (0.01, 0.1, 0.5, 2.5, 5, 10, 25 mg/1), by radioimmunoassays
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