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1

Beroya, M. A. A., and A. Aydin. "First-level liquefaction hazard mapping of Laoag City, Northern Philippines." Natural Hazards 43, no. 3 (June 7, 2007): 415–30. http://dx.doi.org/10.1007/s11069-007-9138-x.

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2

Beroya, M. A. A., and A. Aydin. "Seismic hazard analysis of Laoag City, Northern Philippines for liquefaction potential assessment." Engineering Geology 96, no. 1-2 (January 2008): 28–42. http://dx.doi.org/10.1016/j.enggeo.2007.08.007.

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3

Beroya, M. A. A., and A. Aydin. "A new approach to liquefaction hazard zonation: Application to Laoag City, Northern Philippines." Soil Dynamics and Earthquake Engineering 30, no. 11 (November 2010): 1338–51. http://dx.doi.org/10.1016/j.soildyn.2010.06.007.

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4

Oliveira-Maciel, Diogo, Júlio Souza dos-Santos, Gabriel Oliveira-Silva, Mirian França de Mello, Alessandra Marcia da Fonseca-Martins, Monique Pacheco Duarte Carneiro, Tadeu Diniz Ramos, et al. "MPLA and AddaVax® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis." Microorganisms 9, no. 6 (June 11, 2021): 1272. http://dx.doi.org/10.3390/microorganisms9061272.

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There is so far no vaccine approved for human leishmaniasis, mainly because of the lack of appropriate adjuvants. This study aimed to evaluate in mice the capacity of a mixture of monophosphoryl lipid A (MPLA) and AddaVax® adjuvants in enhancing the efficacy of a Leishvacin®-like vaccine comprised of Leishmania amazonensis whole antigens (LaAg). For that, mice were immunized with LaAg plus MPLA/AddaVax® by the intramuscular route (i.m.) prior to challenge with 2 × 105 and 2 × 106 living parasites. Immunization with LaAg alone reduced the lesion growth of the 2 × 105-challenged mice only in the peak of infection, but that was not accompanied by reduced parasite load, and thus not considered protective. Mice given a 2 × 106 -challenge were not protected by LaAg. The association of LaAg with MPLA/AddaVax® was able to enhance the cutaneous hypersensitivity response compared with LaAg alone. Despite this, there was no difference in proliferative cell response to antigen ex vivo. Moreover, regardless of the parasite challenge, association of LaAg with MPL/AddaVax® did not significantly enhance protection in comparison with LaAg alone. This work demonstrated that MPL/AddaVax® is not effective in improving the efficacy of i.m. LaAg vaccine against cutaneous leishmaniasis.
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5

 . "Laag serumcholesterolgehalte." Medisch-Farmaceutische Mededelingen 35, no. 6 (June 1997): 120–21. http://dx.doi.org/10.1007/bf03056950.

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6

De Meter, Edward C. "Characterization of the Quasi-static Deformation of LAAG Joints Adhering Machined Steel Surfaces." Journal of Manufacturing Science and Engineering 127, no. 2 (April 25, 2005): 350–57. http://dx.doi.org/10.1115/1.1807851.

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Light Activated Adhesive Gripper (LAAG) workholding technology is a means by which a workpiece is held by adhesive joints that can be instantaneously cured or destroyed, on demand. A LAAG joint is the adhesive bond between the gripper pin and workpiece. Due to the novelty of this concept, no knowledge exists with regard to how LAAG joints deform and fail during quasi-static loading. This paper describes an investigation that was carried out to characterize the strength, ductility, and failure modes of a LAAG joint adhering a machined, steel surface subject to axial loading and shear loading.
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7

Kompanje, Erwin J. O. "Een laag Hb." Critical Care 7, no. 2 (April 2010): 16–17. http://dx.doi.org/10.1007/s12426-010-0019-z.

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8

Lourens, Marit, and Loulou Bethe. "'Af Sherry, Laag!'." GZ - Psychologie 12, no. 2 (April 2020): 31. http://dx.doi.org/10.1007/s41480-020-0223-z.

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9

Kreijns, J. M. "De laag-allergene prothese." Tandartspraktijk 33, no. 6 (June 2012): 51–54. http://dx.doi.org/10.1007/s12496-012-0083-9.

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10

Vermunt, Patricia, Max Feltzer, and Kristel van Zon. "Van laag naar gemiddeld." Kind & Adolescent Praktijk 13, no. 1 (March 2014): 4–11. http://dx.doi.org/10.1007/s12454-014-0002-3.

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11

Higuchi, M., and A. Hasegawa. "Fermi surface of LaAg." Zeitschrift f�r Physik B Condensed Matter 98, no. 4 (December 1995): 495–501. http://dx.doi.org/10.1007/bf01320850.

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12

Pinheiro, Roberta O., Eduardo F. Pinto, Alessandra B. Benedito, Ulisses G. Lopes, and Bartira Rossi-Bergmann. "The T-cell anergy induced by Leishmania amazonensis antigens is related with defective antigen presentation and apoptosis." Anais da Academia Brasileira de Ciências 76, no. 3 (September 2004): 519–27. http://dx.doi.org/10.1590/s0001-37652004000300006.

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Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease associated with anergic immune responses. In this study we show that the crude antigen of Leishmania amazonensis (LaAg) but not L. braziliensis promastigotes (LbAg) contains substances that suppress mitogenic and spontaneous proliferative responses of T cells. The suppressive substances in LaAg are thermoresistant (100ºC/1h) and partially dependent on protease activity. T cell anergy was not due to a decreased production of growth factors as it was not reverted by addition of exogenous IL-2, IL-4, IFN-gamma or IL-12. LaAg did not inhibit anti-CD3-induced T cell activation, suggesting that anergy was due to a defect in antigen presentation. It was also not due to cell necrosis, but was accompanied by expressive DNA fragmentation in lymph node cells, indicative of apoptosis. Although pre-incubation of macrophages with LaAg prevented their capacity to present antigens, this effect was not due to apoptosis of the former. These results suggest that the T cell anergy found in diffuse leishmaniasis may be the result of parasite antigen-driven apoptosis of those cells following defective antigen presentation.
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13

Panasia, Gianna, and Bodo Philipp. "LaoABCR, a Novel System for Oxidation of Long-Chain Alcohols Derived from SDS and Alkane Degradation inPseudomonas aeruginosa." Applied and Environmental Microbiology 84, no. 13 (April 20, 2018): e00626-18. http://dx.doi.org/10.1128/aem.00626-18.

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ABSTRACTThe opportunistic pathogenPseudomonas aeruginosastrain PAO1 is able to use a variety of organic pollutants as growth substrates, including the anionic detergent sodium dodecyl sulfate (SDS) and long-chain alkanes. While the enzymes initiating SDS and alkane degradation are well known, the subsequent enzymatic steps for degradation of the derived primary long-chain alcohols have not yet been identified. By evaluating genes specifically induced during growth with SDS, a gene cluster encoding a putative alcohol dehydrogenase (PA0364/LaoA), a probable inner membrane protein (PA0365/LaoB), and a presumable aldehyde dehydrogenase (PA0366/LaoC) was identified and designated the Lao (long-chain-alcohol/aldehyde-oxidation) system. Growth experiments with deletion mutants with SDS, 1-dodecanol, and alkanes revealed that LaoA and LaoB are involved in the degradation of primary long-chain alcohols. Moreover, detection of 1-dodecanol oxidation in cell extracts by activity staining revealed an interdependency of LaoA and LaoB for efficient 1-dodecanol oxidation. Anin silicoanalysis yielded no well-characterized homologue proteins for LaoA and LaoB. Furthermore, a gene adjacent to thelaogene cluster encodes a putative transcriptional regulator (PA0367/LaoR). AlaoRdeletion mutant exhibited constitutive expression of LaoA and LaoB, indicating that LaoR is a repressor for the expression oflaoABC. Taken together, these results showed that the proteins LaoA and LaoB constitute a novel oxidation system for long-chain alcohols derived from pollutants.IMPORTANCEThe versatile and highly adaptive bacteriumPseudomonas aeruginosa is able to colonize a variety of habitats, including anthropogenic environments, where it is often challenged with toxic compounds. Its ability to degrade such compounds and to use them as growth substrates can significantly enhance spreading of this opportunistic pathogen in hygienic settings, such as clinics or water distribution systems. Thus, knowledge about the metabolism ofP. aeruginosacan contribute to novel approaches for preventing its growth and reducing nosocomial infections. As the Lao system is important for the degradation of two different classes of pollutants, the identification of these novel enzymes can be a useful contribution for developing effective antibacterial strategies.
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14

IBUKI, Atsushi. "The Biography of Huian (Daoan, Laoan)." Journal of Indian and Buddhist Studies (Indogaku Bukkyogaku Kenkyu) 58, no. 2 (2010): 640–47. http://dx.doi.org/10.4259/ibk.58.2_640.

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15

LEAL, JANINE MIRANDA, MARCELLE MOSQUINI, LUCIANA POLACO COVRE, NATALY PESCINALLI STAGMILLER, RODRIGO RIBEIRO RODRIGUES, DENNIS CHRISTENSEN, HERBERT LEONEL DE MATOS GUEDES, BARTIRA ROSSI-BERGMANN, and DANIEL CLÁUDIO DE OLIVIERA GOMES. "Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi." Parasitology 142, no. 13 (September 23, 2015): 1640–46. http://dx.doi.org/10.1017/s0031182015001250.

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SUMMARYThe CAF01 adjuvant has previously been shown to be safe for human use and to be a potent adjuvant for several vaccine antigens. In the present work, we sought to optimize the Leishmania amazonensis antigens (LaAg) intranasal vaccine in an attempt to enhance the protective immune responses against Leishmania (infantum) chagasi by using the CAF01 association. LaAg/CAF01 vaccinated mice that were challenged 15 days after booster dose with L. (infantum) chagasi showed a significant reduction in their parasite burden in both the spleen and liver, which is associated with an increase in specific production of IFN-γ and nitrite, and a decrease in IL-4 production. In addition, LaAg/CAF01 intranasal delivery was able to increase lymphoproliferative immune responses after parasite antigen recall. These results suggest the feasibility of using the intranasal route for the delivery of crude antigens and of a human-compatible adjuvant against visceral leishmaniasis.
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16

 . "796 Toezichtlast Caresector Relatief Laag." Zorg en Financiering 7, no. 6 (June 2008): 84. http://dx.doi.org/10.1007/bf03097032.

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17

Niksch, M., B. L�thi, and J. K�bler. "Electron-phonon interaction in LaAg." Zeitschrift f�r Physik B Condensed Matter 68, no. 2-3 (June 1987): 291–98. http://dx.doi.org/10.1007/bf01304242.

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18

Tempelman, Gerdien. "Zorg voor laag geletterde patiënten." Tijdschrift voor praktijkondersteuning 11, no. 5 (October 2016): 34–37. http://dx.doi.org/10.1007/s12503-016-0073-8.

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19

Pinto, Eduardo Fonseca, Roberta Olmo Pinheiro, Alice Rayol, Vicente Larraga, and Bartira Rossi-Bergmann. "Intranasal Vaccination against Cutaneous Leishmaniasis with a Particulated Leishmanial Antigen or DNA Encoding LACK." Infection and Immunity 72, no. 8 (August 2004): 4521–27. http://dx.doi.org/10.1128/iai.72.8.4521-4527.2004.

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ABSTRACT We have previously demonstrated that oral delivery of a disease-promoting particulated antigen of Leishmania amazonensis (LaAg) partially protects mice against cutaneous leishmaniasis. In the present work, we sought to optimize a mucosal vaccine by using the intranasal route for delivery of different antigen preparations, including (i) LaAg, (ii) soluble recombinant p36/LACK leishmanial antigen (LACK), and (iii) plasmid DNA encoding LACK (LACK DNA). BALB/c mice that received two intranasal doses of 10 μg of LaAg and were challenged 1 week postvaccination with L. amazonensis developed delayed but effective control of lesion growth. A diminished parasite burden was accompanied by enhancement of both gamma interferon (IFN-γ) and interleukin-10 levels in the lesion-draining lymph nodes. The vaccine efficacy improved with time. At 4 months postvaccination, when a strong parasite-specific TH1-type response was present in vivo, the infection was controlled for at least 5 months after challenge. In contrast to the particulated LaAg, soluble LACK (10 μg/dose) had no effect. Interestingly, LACK DNA (30 μg/dose), but not empty DNA, promoted rapid and durable protective immunity. Parasite growth was effectively controlled, and at 5 months after challenge LACK-reactive cells in both the mucosal and lesion-draining lymph nodes produced high levels of IFN-γ. These results demonstrate for the first time the feasibility of using the intranasal route for long-lived memory vaccination against cutaneous leishmaniasis with adjuvant-free crude antigens or DNA.
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20

Karpen, Maxine. "Corporate Profile LASAG: The One to Watch." Laser Medicine and Surgery News and Advances 7, no. 1 (February 1989): 29–32. http://dx.doi.org/10.1089/lms.1989.7.1.29.

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21

Schreuder, M. F., M. Fodor, J. A. E. van Wijk, and H. A. Delemarre-van de Waal. "Laag geboortegewicht: consequenties voor de nier?" Tijdschrift voor kindergeneeskunde 70, no. 5 (April 2002): 49–53. http://dx.doi.org/10.1007/bf03061371.

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22

van Marrewijk, Corine, Suhreta Mujakovic, Gerdine Fransen, Mattijs Numans, Niek de Wit, Jean Muris, Martijn van Oijen, et al. "Zuurremmers: hoog inzetten, of juist laag?" Huisarts en Wetenschap 52, no. 8 (August 2009): 374–81. http://dx.doi.org/10.1007/bf03085694.

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23

 . "Niet minder sterfte bij laag homocysteïnegehalte." Huisarts en Wetenschap 51, no. 8 (August 2008): 356. http://dx.doi.org/10.1007/bf03086828.

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24

Kool, Marijke. "Het kind met (te) laag gewicht." Huisarts en wetenschap 59, no. 3 (March 2016): 138. http://dx.doi.org/10.1007/s12445-016-0080-6.

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25

van der Ent, Cornelis K., Jacquelien Noordhoek, and Harry Heijerman. "Farewell to Han van der Laag." Journal of Cystic Fibrosis 4 (August 2005): 1. http://dx.doi.org/10.1016/j.jcf.2005.05.004.

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26

Guo, Kimberly L., Carol L. Karp, Eve J. Higginbotham, Eric O. Griffin, and Marilyn C. Kincaid. "Comparative Efficacy of the SLT versus LASAG Nd." Journal of Glaucoma 4, no. 4 (August 1995): 268???273. http://dx.doi.org/10.1097/00061198-199508000-00009.

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27

Tonog, Merle N., and Marieta M. Poblete. "Drinking Water Quality Assessment in Selected Barangays in Laoang, Northern Samar, Philippines." International Journal of Environmental Science and Development 6, no. 1 (2015): 29–33. http://dx.doi.org/10.7763/ijesd.2015.v6.556.

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28

Aluwé, M., S. Millet, and A. Van den Broeke. "In welke mate beïnvloedt de voederstrategie de smakelijkheid van varkensvlees?" Vlaams Diergeneeskundig Tijdschrift 88, no. 6 (December 31, 2019): 346–47. http://dx.doi.org/10.21825/vdt.v88i6.15994.

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Uit onderzoek aan het Instituut voor Landbouw-, Visserij- en Voedingsonderzoek (ILVO) blijkt dat het voederen van immunocastraten met een laag energetisch voeder in de derde afmestfase de smakelijkheid van het vlees vermindert.
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29

van Berloo, Karik, and Sophie van Kan. "Eerste hulp bij een (te laag) omzetplafond?" Psychopraktijk 7, no. 1 (February 2015): 13. http://dx.doi.org/10.1007/s13170-015-0011-4.

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30

 . "1184 VWS Raamt Rekenpremie Zorgverzekering Te Laag." Zorg en Financiering 5, no. 9 (September 2006): 93–94. http://dx.doi.org/10.1007/bf03093008.

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31

Maarse, Hans, and Patrick Jeurissen. "Laag institutioneel vertrouwen in zorgverzekeraars in Nederland." TBV – Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde 27, no. 8 (September 2019): 15. http://dx.doi.org/10.1007/s12498-019-0087-6.

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32

Plokhikh, Igor, Dmitry Charkin, and Alexey Kuznetsov. "On the stability boundaries of the LaOAgS structure type." Acta Crystallographica Section A Foundations and Advances 73, a2 (December 1, 2017): C889. http://dx.doi.org/10.1107/s2053273317086855.

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33

Charkin, Dmitri O., Dmitri N. Moskvin, Peter S. Berdonosov, Valeri A. Dolgikh, and Philip Lightfoot. "Synthesis of novel LaOAgS-type cation-deficient bismuth oxyhalides." Journal of Alloys and Compounds 413, no. 1-2 (March 2006): 40–45. http://dx.doi.org/10.1016/j.jallcom.2005.06.070.

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34

van Gaalen, Corinne, and Marcel Warnaar. "Een laag inkomen en hoge zorgkosten, kan dat?" Sociaal Bestek 78, no. 4 (August 2016): 25–28. http://dx.doi.org/10.1007/s41196-016-0084-6.

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35

Sato, Hideyuki, Hitoshi Sugawara, Yuji Aoki, Kazuyuki Motoki, Rikio Settai, and Yoshichika Ōnuki. "Transport Properties in LaAg and CeAg Single Crystals." Journal of the Physical Society of Japan 65, no. 5 (May 15, 1996): 1329–33. http://dx.doi.org/10.1143/jpsj.65.1329.

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36

 . "Bewijs ontbreekt voor nut van zeer laag LDL." Huisarts en Wetenschap 49, no. 13 (December 2006): 916. http://dx.doi.org/10.1007/bf03084986.

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37

 . "336 PWC: Tarief Thuis Wonen Is Te Laag." Zorg en Financiering 8, no. 3 (March 2009): 41. http://dx.doi.org/10.1007/bf03098005.

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38

 . "848 Abvakabo: Wmo Bedreigt Werkgelegenheid Laag Opgeleide Vrouwen." Zorg en Financiering 4, no. 6 (June 2005): 37. http://dx.doi.org/10.1007/bf03090966.

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39

 . "Hoop voor coronairpatiënten met een laag HDL-cholesterol." Medisch-Farmaceutische Mededelingen 40, no. 4 (April 2002): 101–2. http://dx.doi.org/10.1007/bf03057908.

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40

 . "1006 Rechtbank Oordeelt: Tarief Huishoudelijke Hulp Te Laag." Zorg en Financiering 6, no. 8 (August 2007): 67–68. http://dx.doi.org/10.1007/bf03094298.

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41

 . "1121 Betere Preventie Kan Laag Wiegendoodcijfer Nog Halveren." Zorg en Financiering 5, no. 7 (July 2007): 170. http://dx.doi.org/10.1007/bf03092945.

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42

Minguez-Galenzoga, Divina. "DIVERSITY OF SHRUBS AND TREES IN THE ISLAND TOWNS OF NORTHERN SAMAR, PHILIPPINES." International Journal of Research -GRANTHAALAYAH 7, no. 3 (March 31, 2019): 208–16. http://dx.doi.org/10.29121/granthaalayah.v7.i3.2019.961.

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This study aimed to identify the shrubs and trees in the five island towns of Northern Samar, Philippines; determine their abundance, community structure; and economic uses to the locals. Four barangays in every island town represented the north, south, east, and west sides. Line Intercept Transect (LIT) at intervals of 100m and plot method with an area of 10m x 10m were used in gathering the data. Transect walks, field plots, and transects were also used in gathering data. There were 207 species of shrubs and trees belonging to 152 genera and 64 families. Shrubs constituted 55.33% and trees 44.67% of the total number of species. Mangifera indica (Anacardiaceae) ranked first in relative density (25.50%), relative frequency (25.30%), and importance value (59.15%). Plots in the island of Laoang were observed to have the highest Shannon Diversity Index (3.25%) and Simpson’s Dominance Index (1.86%). The most abundant shrub and tree species in the island towns were Citrus microcarpa (Cucurbitaceae) and Mangifera indica (Anacardiaceae) respectively. The least abundant shrub and tree species were Gardenia jasminoides (Rubiaceae) and Cananga odorata (Annonaceae) respectively. There were more species of shrubs and trees in the island town of Laoang than in the other four island towns.
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43

Charkin, D. O., P. S. Berdonosov, V. A. Dolgikh, and P. Lightfoot. "Novel lanthanoid–cadmium oxide pnictides with the tetragonal LaOAgS structure." Journal of Alloys and Compounds 292, no. 1-2 (November 1999): 118–23. http://dx.doi.org/10.1016/s0925-8388(99)00293-5.

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44

Jani, Mattie White, Leon A. Rosenbe, Sushma. "Munchausen Syndrom by Proxy." International Journal of Psychiatry in Medicine 22, no. 4 (January 1, 1993): 1. http://dx.doi.org/10.2190/pneq-laag-990p-pfau.

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45

De Meter, Edward C. "Light Activated Adhesive Gripper (LAAG) Workholding Technology and Process." Journal of Manufacturing Processes 6, no. 2 (January 2004): 201–14. http://dx.doi.org/10.1016/s1526-6125(04)70075-4.

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46

Motoki, Kazuyuki, Rikio Settai, Noriaki Kimura, Hiroyuki Toshima, Takao Ebihara, Haruhisa Ikezawa, Hitoshi Sugawara, Yoshichika Ōnuki, and Hisatomo Harima. "de Haas-van Alphen Effect in LaAg and CeAg." Journal of the Physical Society of Japan 64, no. 9 (September 15, 1995): 3328–35. http://dx.doi.org/10.1143/jpsj.64.3328.

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47

van Weert, Henk. "Is een laag HbA1c een risico in het verkeer?" Huisarts en wetenschap 53, no. 5 (May 2010): 244. http://dx.doi.org/10.1007/s12445-010-0105-5.

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48

 . "175 Consumptie Groenten En Fruit Jongvolwassenen Veel Te Laag." Zorg en Financiering 4, no. 1 (January 2005): 177. http://dx.doi.org/10.1007/bf03090293.

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49

 . "641 Doelmatig Geneesmiddelengebruik: Kwaliteit Tegen Zo Laag Mogelijke Kosten." Zorg en Financiering 4, no. 4 (April 2005): 112. http://dx.doi.org/10.1007/bf03090759.

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50

 . "Atriumfibrilleren: acetylsalicylzuuracetylsalicylzuur voor patiënten met laag risico kan ook." Medisch-Farmaceutische Mededelingen 38, no. 9 (September 2000): 183–84. http://dx.doi.org/10.1007/bf03057594.

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