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1

Johnson, C. Shanthi. Health and aging in the world's largest democracy. Hauppauge, N.Y: Nova Science, 2010.

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2

Lee, Wilke W., and Fails Anna Dee, eds. Anatomy and physiology of farm animals. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2003.

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3

Frandson, R. D. Anatomy and physiology of farm animals. 4th ed. Philadelphia: Lea & Febiger, 1986.

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4

Frandson, R. D. Anatomy and physiology of farm animals. 5th ed. Philadelphia: Lea & Febiger, 1992.

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5

Blais, Catherine. Rôle et métabolisme des ecdystéroïdes au niveau des disques imaginaux alaires de Pieris brassicae L. (Lépidoptère). Paris: E.N.S. Laboratoire de zoologie, 1986.

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6

International, Conference on the Lacrimal Gland Tear Film and Dry Eye Syndromes (3rd 2000 Maui Hawaii). Lacrimal gland, tear film, and dry eye syndromes 3: Basic science and clinical relevance. New York: Kluwer Academic/Plenum Pub., 2002.

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7

A, Sullivan David, ed. Lacrimal gland, tear film, and dry eye syndromes 3: Basic science and clinical relevance. New York: Kluwer Academic/Plenum Pub., 2002.

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8

International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes (3rd 2000 Maui, Hawaii). Lacrimal gland, tear film, and dry eye syndromes 3: Basic science and clinical relevance. New York: Kluwer Academic/Plenum Pub., 2002.

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9

Ashdown, Raymond R. The horse. Philadelphia: Lippincott, 1987.

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10

Ashdown, Raymond R. The horse. London: Mosby-Wolfe, 1996.

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11

Camp, L. Sprague De. The fallible fiend. Waterville, Me: Thorndike Press, 2002.

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12

A, Kainer Robert, and Spurgeon Thomas Leslie, eds. Spurgeon's color atlas of large animal anatomy: The essentials. Philadelphia: Lippincott Williams & Wilkins, 1999.

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13

The mature mind: The positive power of the aging brain. New York: Perseus Books Group, 2005.

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14

H, Done Stanley, ed. The ruminants. 2nd ed. Edinburgh: Mosby, 2010.

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15

H, Done Stanley, ed. The ruminants. London: Mosby-Wolfe, 1996.

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16

Benson, Herbert. The Relaxation Response. New York: HarperCollins, 2009.

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17

Z, Klipper Miriam, ed. The relaxation response. New York: Wings Books, 1992.

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18

Z, Klipper Miriam, ed. The relaxation response. New York, NY: Quill, 2001.

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19

Benson, Herbert. The relaxation response. New York, N.Y: HarperTorch, 2000.

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20

Jaeckle, William, ed. Physiology of Larval Feeding. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198786962.003.0009.

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The functional properties of marine invertebrate larvae represent the sum of the physiological activities of the individual, the interdependence among cells making up the whole, and the correct positioning of cells within the larval body. This chapter examines physiological aspects of nutrient acquisition, digestion, assimilation, and distribution within invertebrate larvae from an organismic and comparative perspective. Growth and development of larvae obviously require the acquisition of “food.” Yet the mechanisms where particulate or dissolved organic materials are converted into biomass and promote development of larvae differ and are variably known among groups. Differences in the physiology of the digestive system (secreted enzymes, gut transit time, and assimilation) within and among feeding larvae suggest the possibility of an underappreciated plasticity of digestive physiology. How the ingestion of seawater by and the existence of a circulatory system within larvae contribute to larval growth and development represent important topics for future research.
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21

Williams, Elizabeth A., and Tyler J. Carrier, eds. An -omics Perspective on Marine Invertebrate Larvae. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198786962.003.0019.

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The diverse phenotypes exhibited by marine invertebrate larvae are the result of complex gene-environment interactions. Recently, technological advances in molecular biology have enabled large-scale -omics approaches, which can provide a global overview of the molecular mechanisms that shape the larval genotype-phenotype landscape. -omics approaches are facilitating our understanding of larval development and life history evolution, larval response to environmental stress, the larval microbiome, larval physiology and feeding, and larval behavior. These large-scale molecular approaches are even more effective when combined with large-scale environmental monitoring and phenotypic measurements. Current -omics approaches to studying larvae can be improved by the addition of functional genetic analyses and the reporting of natural variation in gene expression between individuals and populations. Systems-level approaches that combine multiple -omics techniques will allow us to explore in fine detail the interactions of environmental and genotypic influences on larval phenotype.
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22

N, Finn R., and Kapoor B. G, eds. Fish larval physiology. Enfield, NH: Science Publishers, 2008.

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23

N, Finn R., and Kapoor B. G, eds. Fish larval physiology. Enfield, NH: Science Publishers, 2008.

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24

Harrison, Mark. Gastrointestinal physiology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0035.

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This chapter describes gastrointestinal physiology as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of the functional anatomy of the gastrointestinal tract, saliva, swallowing, stomach, small intestine, pancreas, liver, gallbladder, and large intestine. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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25

The Remarkable Life of the Skin: An Intimate Journey Across Our Largest Organ. Atlantic Monthly Press, 2020.

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26

Blaser, Annika Reintam, and Adam M. Deane. Normal physiology of nutrition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0201.

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Energy is derived from three major categories of macronutrient—carbohydrate, lipid, and protein. While energy requirements to maintain stable weight can be estimated, it is uncertain if meeting these energy requirements improves outcomes in the critically ill. In health, excess energy is stored via non-oxidative metabolism and during periods of inadequate energy delivery catabolism of storage products occurs. Both storing and using the stores cost energy, each may require up to quarter of energy contained in stored nutrient. Excess carbohydrate stored as glycogen is easily available, albeit in a limited amount. Storage of lipid is the largest energy repository, but requires complex metabolism and is limited by low oxidative capacity. Protein catabolism normally contributes less than 5% of energy requirements, but during periods of inadequate energy delivery or increased catabolism there is a marked increase in endogenous protein breakdown.
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27

Yang, Jingduan, and Daniel A. Monti. Physiology of the Internal Organs. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190210052.003.0004.

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This chapter provides a detailed description of the concepts of internal human organs from a Chinese medicine perspective, including two additional organs: Pericardium and San Jiao (cavities of chest, abdomen, and pelvic). It describes in detail the manifestation (Xiang) of physiological functions of solid organs (Zang) such as the Heart, Liver, Lungs, Spleen, Kidneys, and Pericardium, and hollow organs (Fu) such as Small Intestine, Larger Intestine, Gallbladder, Bladder, Stomach, and San Jiao. It teaches the functions that overlap largely with modern medical physiology as well as the additional functions due to the energetic connections of each internal organ with the rest of the body, including their specific impacts on sensory faculties, connective tissues, body gestures and movements, and body fluids. This chapter emphasizes that the internal organs in acupuncture and Chinese medicine should be perceived not only as structural and biochemical centers but also as energetic centers.
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28

Petrella, Carla, Giuseppe Nisticò, and Robert Nisticò. Gut–brain axis: Physiology and pathology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0007.

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A large body of research has shown the presence of a complex pathway of communication between gut and brain. It is now recognized that, through this pathway, microbiota can influence intestinal homeostasis and modulate brain plasticity in normal and pathological conditions. This chapter provides an overview of preclinical and clinical evidence supporting the possible mechanisms whereby microbiota can influence gastrointestinal function and stress-related behaviour. Since normalization of gut flora can prevent changes in behaviour, the authors further postulate that the gut–brain axis might represent a possible target for pharmacological and dietary strategies aimed at improving intestinal and mental health.
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29

Lumb, Andrew B., and Natalie Drury. Respiratory physiology in anaesthetic practice. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0002.

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Moving away from the structure of traditional texts, this chapter follows the journey of oxygen molecules as they move from inspired air to their point of use in mitochondria, with some digressions along the way to cover other relevant aspects of respiratory physiology. The chapter encompasses all the key aspects of respiratory physiology and also highlights physiological alterations that occur under both general and regional anaesthesia, moving the physiological principles discussed into daily anaesthetic practice. The chapter explores relevant anatomy of the airways, lungs, and pleura. The histology and function of the airway lining and alveoli are described, so illustrating the importance of pulmonary defence mechanisms for protecting the internal milieu of the body from this large and fragile interface with the outside world. Key principles and concepts including resistance, compliance, and diffusion are all discussed in their clinical context. Concepts relating to the mechanics of breathing and the control of airway diameter are considered along with lung volumes and their measurement. Both the central and peripheral mechanisms involved in the control of breathing are discussed with particular attention to the impact of anaesthesia. The relationship between ventilation and perfusion and the carriage of oxygen and carbon dioxide are all discussed in detail. The principles behind key respiratory measurements such as dead space, lung volumes, diffusing capacity, and shunt are all described. Overall the chapter provides a comprehensive review of respiratory physiology as well as including additional aspects of variation that occur under anaesthesia.
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30

1933-, Phillips Sidney F., Pemberton John H, and Shorter Roy G. 1925-, eds. The Large intestine: Physiology, pathophysiology, and disease. New York: Raven Press, 1991.

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31

Hernandez, Michael R. Tracheoesophageal Fistula. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0017.

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Tracheoesophageal fistula (TEF) in the neonate is a complex congenital disorder that may occur in isolation or as part of a larger association of findings (i.e., VACTERL association). Care of these patients must include testing to clarify the anatomic and physiologic characteristics of each finding. This is particularly important for planning of surgical and anesthetic care. Surgical options for TEF repair vary in location of incision and also whether the approach is open or minimally invasive. Patients with severe congenital heart disease, such as hypoplastic left heart syndrome, pose unique challenges to the perioperative caregiver. The anesthesia team must balance the patient’s pulmonary and systemic blood flow while still heeding the need to avoid excessive ventilation via the TEF. Regional analgesia may provide the option of early extubation after TEF repair, but risks must be weighed against the patient’s anatomic and physiologic status.
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32

Feltwell, John. Large White Butterfly: "The Biology, Biochemistry and Physiology of Pieris Brassicae ". Springer, 2011.

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33

Fails, Anna Dee, W. Lee Wilke, and Rowen D. Frandson. Anatomy and Physiology of Farm Animals. Wiley & Sons, Incorporated, John, 2013.

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34

Fails, Anna Dee, and Christianne Magee. Anatomy and Physiology of Farm Animals. Wiley & Sons, Incorporated, John, 2018.

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35

Fails, Anna Dee, and Christianne Magee. Anatomy and Physiology of Farm Animals. Wiley & Sons, Incorporated, John, 2018.

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36

Anatomy and Physiology of Farm Animals. Wiley & Sons, Incorporated, John, 2018.

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37

Fails, Anna Dee, W. Lee Wilke, and R. D. Frandson. Anatomy and Physiology of Farm Animals, 6th Edition. 6th ed. Lippincott Williams & Wilkins, 2003.

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38

Ho, Kwok M. Kidney and acid–base physiology in anaesthetic practice. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0005.

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Anatomically the kidney consists of the cortex, medulla, and renal pelvis. The kidneys have approximately 2 million nephrons and receive 20% of the resting cardiac output making the kidneys the richest blood flow per gram of tissue in the body. A high blood and plasma flow to the kidneys is essential for the generation of a large amount of glomerular filtrate, up to 125 ml min−1, to regulate the fluid and electrolyte balance of the body. The kidneys also have many other important physiological functions, including excretion of metabolic wastes or toxins, regulation of blood volume and pressure, and also production and metabolism of many hormones. Although plasma creatinine concentration has been frequently used to estimate glomerular filtration rate by the Modification of Diet in Renal Disease (MDRD) equation in stable chronic kidney diseases, the MDRD equation has limitations and does not reflect glomerular filtration rate accurately in healthy individuals or patients with acute kidney injury. An optimal acid–base environment is essential for many body functions, including haemoglobin–oxygen dissociation, transcellular shift of electrolytes, membrane excitability, function of many enzymes, and energy production. Based on the concepts of electrochemical neutrality, law of conservation of mass, and law of mass action, according to Stewart’s approach, hydrogen ion concentration is determined by three independent variables: (1) carbon dioxide tension, (2) total concentrations of weak acids such as albumin and phosphate, and (3) strong ion difference, also known as SID. It is important to understand that the main advantage of Stewart over the bicarbonate-centred approach is in the interpretation of metabolic acidosis.
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39

Stasic, Andrew F. Undiagnosed Pheochromocytoma. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0027.

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Pheochromocytomas are neuroendocrine tumors that secrete large amounts of vasoactive catecholamines resulting in excessive tachycardia and hypertension. These rapid physiologic perturbations can be especially dangerous in patients at risk for stroke and myocardial infarction. Pharmacologic preparation of patients with known pheochromocytomas preoperatively can take many days of advance notice, but doing so successfully will significantly reduce the likelihood of intraoperative hemodynamic complications. Patients who present intraoperatively with undiagnosed pheochromocytomas pose unusual challenges for the anesthesiologist. Prompt recognition of the possibility of an undiagnosed pheochromocytoma and rapid treatment with the appropriate vasoactive drugs may be life saving.
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40

Burton, Derek, and Margaret Burton. Obtaining information. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198785552.003.0015.

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Large numbers of scientific publications about fish appear each year, resulting in accumulation of a vast quantity of information, and this has become a major enterprise. However, much of the information concerns identification of fish and their habitats, and logistical considerations result in concentration of experimental work on relatively few species. Commercial exploitation of fish species also influences decisions on which to study. The main types of information sources are reviewed as well as ‘type’ fish for particular studies in anatomy and physiology. However, given the large number of fish species and adaptive diversity extrapolation of information from any single one should be conservative and may give rise to problems, including skewed conclusions.
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41

Khanna, Ashish K., and Piyush Mathur. Bariatric Surgery and Acute Cardiovascular Complications in the ICU. Edited by Tomasz Rogula, Philip Schauer, and Tammy Fouse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190608347.003.0019.

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The increased numbers of bariatric surgical procedures worldwide have translated into a higher number of postoperative intensive care unit (ICU) admissions. The pathophysiologic perturbations in obesity mean that a large fraction of bariatric surgical patients have both diagnosed and undiagnosed underlying coronary artery disease, hypertension, cardiac rhythm disturbances, and baseline cardiac dysfunction. Manifestations of cardiac complications in this patient population are usually extremely subtle, both intraoperatively under anesthesia and in the ICU during the immediate postoperative period. Furthermore, the patients’ poor physiologic reserve does not allow for periods of hypoperfusion secondary to cardiovascular insufficiency. It is incumbent on the intensivist taking care of these patients to develop a specific skill set focused on early identification of cardiovascular complications in the postoperative period. This chapter highlights some specific cardiovascular complications in bariatric surgery patients, management of the complications, and recommendations for prevention, with a focus on some pertinent surgery-specific issues.
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42

Rudneva, Irina. Biomarkers for Stress in Fish Embryos and Larvae. Taylor & Francis Group, 2013.

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43

Rudneva, Irina. Biomarkers for Stress in Fish Embryos and Larvae. Taylor & Francis Group, 2013.

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44

Rudneva, Irina. Biomarkers for Stress in Fish Embryos and Larvae. Taylor & Francis Group, 2013.

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45

Biomarkers for Stress in Fish Embryos and Larvae. Taylor & Francis Group, 2013.

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46

Rudneva, Irina. Biomarkers for Stress in Fish Embryos and Larvae. Taylor & Francis Group, 2013.

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47

Esler, Karen J., Anna L. Jacobsen, and R. Brandon Pratt. Form and Function of Mediterranean Shrublands. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198739135.003.0006.

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The archetypal shrub type that dominates most of the regions that experience mediterranean-type climate (MTC) is an evergreen shrub with thick and leathery leaves (sclerophyllous). The occurrence of large stands of such shrubs in all MTC regions led early biogeographers to hypothesize that the MTC selects for this growth form and leaf type and that this had led to convergent evolution (see Chapters 1 and 2). This hypothesis has received considerable research interest and continues to be examined. In this chapter we consider the structure and physiology of these archetypal MTC region shrub species and examine evidence for convergent evolution in their structure and function. We also assess the key adaptive traits that enable the shrub species that compose mediterranean-type vegetation (MTV) communities to thrive in MTC regions.
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48

Kirchman, David L. Microbial primary production and phototrophy. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0006.

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This chapter is focused on the most important process in the biosphere, primary production, the turning of carbon dioxide into organic material by higher plants, algae, and cyanobacteria. Photosynthetic microbes account for roughly 50% of global primary production while the other half is by large, terrestrial plants. After reviewing the basic physiology of photosynthesis, the chapter discusses approaches to measuring gross and net primary production and how these processes affect fluxes of oxygen and carbon dioxide into and out of aquatic ecosystems. It then points out that terrestrial plants have high biomass but relatively low growth, while the opposite is the case for aquatic algae and cyanobacteria. Primary production varies greatly with the seasons in temperate ecosystems, punctuated by the spring bloom when the biomass of one algal type, diatoms, reaches a maximum. Other abundant algal types include coccolithophorids in the oceans and filamentous cyanobacteria in freshwaters. After the bloom, small algae take over and out-compete larger forms for limiting nutrients because of superior uptake kinetics. Abundant types of small algae include two coccoid cyanobacteria, Synechococcus and Prochlorococcus, the latter said to be the most abundant photoautotroph on the planet because of its large numbers in oligotrophic oceans. Other algae, often dinoflagellates, are toxic. Many algae can also graze on other microbes, probably to obtain limiting nitrogen or phosphorus. Still other microbes are mainly heterotrophic but are capable of harvesting light energy. Primary production in oxic environments is carried out by oxygenic photosynthetic organisms, whereas in anoxic environments with sufficient light, it is anaerobic anoxygenic photosynthesis in which oxygen is not produced. Although its contribution to global primary production is small, anoxygenic photosynthesis helps us understand the biophysics and biochemistry of photosynthesis and its evolution on early Earth. These microbes as well as aerobic phototrophic and heterotrophic microbes make up microbial mats. These mats can provide insights into early life on the planet when a type of mat, “stromatolites,” covered vast areas of primordial seas in the Proterozoic.
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49

O’Callaghan, Chris A. Renal function. Edited by Rutger Ploeg. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0126.

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The kidneys play a central role in homeostasis by maintaining extracellular fluid composition and volume. They do this by continuous filtration of plasma in the renal glomeruli and then subsequent modification of the filtered fluid as it passes along the nephron. The filtration process excludes large molecules, but most small molecules and ions are freely filtered. The filtrate that is produced in the glomeruli has a similar composition to plasma with respect to small molecules and ions. Most of the water and solutes are reabsorbed along the tubules and this process requires high levels of metabolic activity. In addition, a range of compounds and ions are secreted into the tubules along the nephron. Renal function is central to homeostasis and an appreciation of normal renal physiology is essential to understand the role of the kidney in a wide variety of disease processes.
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50

Fye, W. Bruce. The Reinvention of the American Heart Association and the Invention of Cardiac Catheterization. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199982356.003.0008.

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President Harry Truman signed the National Heart Act in 1948, which resulted in the creation of the National Heart Institute and started federal funds flowing to academic centers to support cardiovascular research. Mayo cardiologist Arlie Barnes’s term as president of the American Heart Association coincided with its transformation from a low-budget professional society into a large voluntary health organization that raised funds from the public to support its programs. World War II research into shock contributed to the development of cardiac catheterization as a clinical diagnostic tool. Mayo’s wartime research program that focused on ways to protect fighter pilots from blackouts due to high gravitational forces led to the invention of technologies to measure blood pressure and blood oxygen content. Physiologist Earl Wood used these tools in Mayo’s cardiac catheterization laboratory, which was established at the institution in 1947. The clinic helped pioneer the emerging field of cardiac catheterization.
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