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1

Mnif, N., H. Rajhi, H. Belhiba, and S. Esseghaier. "Radio-anatomie normale du larynx." Journal de Radiologie 88, no. 10 (October 2007): 1489. http://dx.doi.org/10.1016/s0221-0363(07)81533-2.

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2

Chevalier, Dominique, Frédérique Dubrulle, and Bernard Vilette. "Anatomie descriptive, endoscopique et radiologique du larynx." EMC - Oto-rhino-laryngologie 1, no. 1 (January 2006): 1–13. http://dx.doi.org/10.1016/s0246-0351(01)00047-2.

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3

Céruse, P., A. Ltaief-Boudrigua, G. Buiret, A. Cosmidis, and S. Tringali. "Anatomie descriptive, endoscopique et radiologique du larynx." EMC - Oto-rhino-laryngologie 7, no. 2 (June 2012): 1–28. http://dx.doi.org/10.1016/s0246-0351(12)56065-4.

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4

Kutta, H., S. Knipping, H. Claassen, and F. Paulsen. "Update Larynx: funktionelle Anatomie unter klinischen Gesichtspunkten." HNO 55, no. 7 (July 2007): 583–98. http://dx.doi.org/10.1007/s00106-007-1556-2.

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5

Kutta, H., S. Knipping, H. Claassen, and F. Paulsen. "Update Larynx: funktionelle Anatomie unter klinischen Gesichtspunkten." HNO 55, no. 8 (April 13, 2007): 661–76. http://dx.doi.org/10.1007/s00106-007-1557-1.

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6

Prades, J. M., M. Gavid, J. M. Dumollard, A. Timoshenko, M. Péoc’h, and C. Martin. "Anatomie chirurgicale de la commissure antérieure du larynx." Morphologie 98, no. 322 (September 2014): 104–5. http://dx.doi.org/10.1016/j.morpho.2014.04.020.

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7

Filler, Timm J. "Funktionelle Anatomie des kraniozervikalen Übergangs." AkupunkturPraxis 02, no. 03 (August 2021): 153–62. http://dx.doi.org/10.1055/a-1481-3746.

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Die kraniozervikale Transitionszone beinhaltet über den kraniovertebralen Übergang hinaus eine Reihe von Komponenten, die eine hohe Spezialisierung beim Menschen entwickelt haben. Wegen der daraus resultierenden Vielzahl von möglichen Pathologien ist es wichtig, sich dieser besonderen Zusammensetzung bewusst zu sein. So vereinen Atlas, Axis und C3 in sich die meisten Differenzierungen von Grundelementen der Wirbelsäule und wirken dabei mit ebenso ungewöhnlichen Komponenten der Binde- und Stützgewebe zusammen. Die Muskulatur hat über die Bewegung und Sensorik hinaus Leistungen für die Passage zu Pharynx und Larynx zu erbringen. Neben dem Bewegungsapparat erwachsen Krankheitsbilder auch aus Störungen der Leitungsbahnen, also Gefäßen und Nerven.
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8

Abi-Khalil, S., N. Aoun, L. Menassa-Moussa, and M. Ghossain. "ANAT-WP-3 Anatomie du larynx sur scanner 64 canaux." Journal de Radiologie 88, no. 10 (October 2007): 1509. http://dx.doi.org/10.1016/s0221-0363(07)81607-6.

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9

Rajhi, H., H. Belhiba, A. Salem, N. Mnif, M. Felfel, H. Kooli, M. Ferjaoui, and R. Hamza. "TC11 Radio-anatomie normale et imagerie du larynx tumoral : CD-Rom d’auto-enseignement." Journal de Radiologie 85, no. 9 (September 2004): 1534. http://dx.doi.org/10.1016/s0221-0363(04)77774-4.

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10

Prades, J. M., M. Gavid, J. M. Dumollard, A. Timoshenko, M. Peco’h, and C. Martin. "Anatomie chirurgicale de l’anse cervicale : application à la ré-innervation du larynx paralysé chez l’homme." Morphologie 97, no. 318-319 (October 2013): 80–81. http://dx.doi.org/10.1016/j.morpho.2013.09.051.

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11

Eko, Vicky, and Rokhaeni Rokhaeni. "Penatalaksanaan Hemangioma Kavernosa Laring." Oto Rhino Laryngologica Indonesiana 48, no. 2 (January 30, 2019): 189. http://dx.doi.org/10.32637/orli.v48i2.207.

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Latar belakang: Hemangioma merupakan proliferasi dari pembuluh darah yang tidak normal dan dapat terjadi pada setiap jaringan pembuluh darah. Adanya massa di laring harus dibedakan sebagai suatu proses inflamasi, atau massa tumor seperti polip laring, karsinoma laring, atau hemangioma. Tujuan: Untuk mengetahui hemangioma kavernosa laring dan penatalaksanaannya. Laporan kasus: Pasien laki-laki, 45 tahun dengan keluhan suara serak yang terus-menerus sejak 1 tahun sebelum masuk rumah sakit. Keluhan serak makin lama makin berat dan dirasakan sangat parah dalam 1 bulan terakhir. Keluhan sesak dan batuk tidak ada, riwayat merokok ada, pekerjaan petani, dan sering terpapar obat hama. Pada pemeriksaan endoskopi kaku 700 didapatkan massa menutup laring, batas tidak tegas, dan pada pemeriksaan CT Scan laring didapatkan massa pada laring bilateral. Dari pemeriksaan Patologi Anatomi didapatkan kesimpulan hemangioma kavernosa. Penatalaksanaan pasien ini berupa trakeostomi dengan anestesi lokal, dan bedah laring mikroskopi dengan anestesi umum. Metode: Telaah literatur berbasis bukti mengenai hemangioma kavernosa laring melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan 3 jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Berdasarkan literatur bahwa hemangioma kavernosa laring merupakan kasus jarang, dan lokasi yang sering terjadi di regio supraglotis dan glotis. Gejala tersering yaitu suara serak. Faktor yang mempengaruhi pilihan terapi adalah usia pasien, tipe, ukuran dan lokalisasi tumor. Kesimpulan: Penatalaksanaan hemangioma kavernosa laring berupa trakeostomi dan bedah laring mikroskopik dengan hasil yang baik. Background: Hemangioma is an abnormal proliferation of blood vessels and it can occur in any blood vessel tissue. The presence of laryngeal masses has to be differentiated as an inflammation process or tumor mass such as polyps of the larynx, laryngeal carcinoma, or hemangioma. Purpose: To gain knowledge of laryngeal cavernous hemangioma and its management. Case Report: Male, 45 years old, complained of persistent hoarseness for about 1 year, and getting much worse since the last month. No complaint of breathing difficulty nor coughing. Had a positive history of smoking, worked as a farmer, often exposed to insecticides. A seventy degree rigid endoscopy examination showed an irregular shaped mass occluding the larynx, indistinct borders, and the CT scan confirmed an isodense mass in larynx bilaterally. The Pathology Anatomy examination result concluded as cavernous hemangioma. The patient underwent tracheostomy with local anesthesia and microlaryngoscopic surgery under general anesthesia. Method: An evidence based literature study on laryngeal cavernous hemangioma was performed through Cochrane and Pubmed Medline. Based on inclusion and exclusion criteria, there were 3 journals which were relevant with the case report. Result: Literature study revealed that laryngeal cavernous hemangioma is a rare case. The frequent location was in supraglotis and glotis regions. Conclusion: The management of laryngeal cavernous hemangioma consisted of tracheostomy and microlaryngoscopic surgery with good result.
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12

Mo, Ting-Ting, Jia-Jie Tan, Mei-Gui Wang, Yuan-Feng Dai, Xiong Liu, and Xiang-Ping Li. "Optimized Generation of Primary Human Epithelial Cells from Larynx and Hypopharynx: A Site-Specific Epithelial Model for Reflux Research." Cell Transplantation 28, no. 5 (March 27, 2019): 630–37. http://dx.doi.org/10.1177/0963689719838478.

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Laryngopharyngeal reflux (LPR) induces a differential damage effect on several anatomic sites within the larynx and hypopharynx; therefore, an in vitro model is needed for each anatomic site. This study aimed to establish a primary culture method for human laryngeal and hypopharyngeal epithelial cells derived from multiple anatomic sites. Surgical mucosa specimens were treated with a two-step enzymatic strategy to establish a primary culture. Of the 46 samples, primary cultivation was achieved successfully with 36 samples, and the positive ratio was 78.3%. In addition, flow cytometry revealed that these primary cells were epithelial cells with a purity of 94.9%. The proliferative ability was confirmed by positive staining for Ki-67. Laryngeal and hypopharyngeal epithelial cells from multiple sites exhibited similar epithelial morphology and positive cytokeratin expression. These cells can be cultured to passage 4. In summary, we successfully established the in vitro epithelial model of larynx and hypopharynx subsites, which may potentially be used as a platform for reflux research, especially for site-specific damage effect.
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13

Lutsay, Elena D., Maksim I. Anikin, and Nuria I. Murtazina. "Formation of larynx topographic-anatomic relations with neck organs and structures in the intermediate fetal period of ontogenesis." Science and Innovations in Medicine 4, no. 4 (December 15, 2019): 16–20. http://dx.doi.org/10.35693/2500-1388-2019-4-4-16-20.

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Objectives - to present topographic and anatomic characteristics of the larynx relationship with neck organs and structures in the intermediate fetal period of human ontogenesis. Material and methods. The study included 85 organocomplexes of the fetuses neck of both sexes, from the 14th to the 27th week of development. The study material was divided into 2 age periods: the first group - fetuses aged 14-20 weeks; the second group - 21-27 weeks. The classical morphological techniques were used: (macromicroscopic preparation, modified method of saw cuts according to N.I. Pirogov, histotopographic method). Results. Larynx syntopy with thyroid gland, cervical esophagus, thymus, submandibular glands was described in detail. Larynx skeletotopy with incisurae jugularis sterni, cervical vertebrae, hyoid bone, mandible was described quantitatively. Conclusion. The data, obtained as a result of the study, supplement the data on the topographic anatomy of larynx and some neck organs and structures in the prenatal period of human ontogenesis. The revealed formation features of larynx and other neck organs and structures topography can be used in the study of intravital anatomy.
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14

Gupta, Ajay, and Robert J. Young. "Supraglottic Larynx and Hypopharynx: An Important Anatomic Distinction." RadioGraphics 31, no. 1 (January 2011): 116. http://dx.doi.org/10.1148/radiographics.31.1.311116.

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15

Helliwell, Tim, Rebecca Chernock, Jane E. Dahlstrom, Nina Gale, Jonathan McHugh, Bayardo Perez-Ordoñez, Nick Roland, Nina Zidar, and Lester D. R. Thompson. "Data Set for the Reporting of Carcinomas of the Hypopharynx, Larynx, and Trachea: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting." Archives of Pathology & Laboratory Medicine 143, no. 4 (November 30, 2018): 432–38. http://dx.doi.org/10.5858/arpa.2018-0419-sa.

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The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Standardized pathologic reporting for cancers facilitates improved communication for patient care and prognosis and the comparison of data between countries to progressively improve clinical outcomes. Laryngeal cancers are often accompanied by significant morbidity, although surgical advances (such as transoral endoscopic laser microresection and transoral robotic surgery) provide new alternatives. The anatomy of the larynx is complex, with an understanding of the exact anatomic sites and subsites, along with recognizing anatomic landmarks, being crucial to classification and prognostication. This review outlines the data set developed for the histopathology reporting in Carcinomas of the Hypopharynx, Larynx and Trachea and discusses the main elements required and recommended for reporting.
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16

Mazengenya, Pedzisai, and Rashid Bhikha. "A critique on Avicenna’s (980 – 1037 A.D) studies on anatomy of the upper respiratory system and some otorhinolaryngologic concepts." Bangladesh Journal of Medical Science 16, no. 2 (March 23, 2017): 188–93. http://dx.doi.org/10.3329/bjms.v16i2.29422.

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Background: Avicenna (also known as Ibn Sina) was arguably one of the outstanding medical scientists and physicians of the time. He made significant contributions in the development of various medical fields in the golden age of Islamic medicine (9-12th century AD) and in Europe. Ibn Sina contributed immensely to human anatomy, physiology, pathology and management of most disorders of the human body. Of paramount importance was the systemic description of the anatomy of various organs and surgical interventions associated with the problems. Although neither formal dissection nor surgical training was recorded during his time, the anatomic and surgical information presented in the Canon of Medicine is congruent with modern advancement. The current study was undertaken to compare Avicenna’s anatomy of the ear, nose, oral cavity, throat and larynx to modern anatomical texts.Methods: The current work analysed the anatomy information on the ear, nose, oral cavity, throat and the larynx as presented in volumes one and three of the Canon of Medicine. The information was compared to modern anatomic descriptions.Results: Avicenna described correctly the anatomy and functions of the external and internal ear, nose, oral cavity, parts of the throat and larynx. He described voice production in the larynx and subsequent contributions on the nose, uvula and tongue in shaping the syllables. The functional aspects, disorders and their management associated with the ear and the upper respiratory system were also described.Conclusions: The findings show that Ibn Sina’s contributions had a major influence on the development and advancement of medical practise. His anatomic explanations are comparable to modern knowledge on the subject. They also show that the Canon of Medicine is still a valuable book in the study of the history of medicine.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.188-193
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17

Kost, Karen M., and David E. Eibling. "Is it a Normal Larynx? Spectrum of Normal Videolaryngoscopy." Otolaryngology–Head and Neck Surgery 112, no. 5 (May 1995): P127—P128. http://dx.doi.org/10.1016/s0194-5998(05)80327-4.

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18

Kokoska, Mimi S., Jay F. Piccirillo, and Bruce H. Haughey. "Gender Differences in Cancer of the Larynx." Annals of Otology, Rhinology & Laryngology 104, no. 6 (June 1995): 419–24. http://dx.doi.org/10.1177/000348949510400601.

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Gender differences in the incidence and mortality rates for cancers of the lung, colon, and larynx have previously been noted. The goal of this project was to identify gender differences in prognostic variables for survival and recurrence for patients with cancer of the larynx. The medical records of 193 patients with cancer of the larynx treated initially between 1973 and 1985 were examined retrospectively. A total of 151 men and 42 women were included. A majority of men developed glottic cancers, whereas a majority of women developed supraglottic cancers. Age was prognostically important for both genders; however, comorbidity, symptom severity, anatomic subsite, and TNM stage all had different impacts on survival and recurrence in men and women. No gender difference in initial treatment was found. This study suggests that when designing and analyzing the results from clinical studies of cancer of the larynx, it is important to employ stratification based on gender.
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19

Cohen, Seymour R., Natasha Perelman, Vladimir Mahnovski, Marcel E. Nimni, and David T. Cheung. "Whole Organ Evaluation of Collagen in the Developing Human Larynx and Adjoining Anatomic Structures (Hyoid and Trachea)." Annals of Otology, Rhinology & Laryngology 102, no. 9 (September 1993): 655–59. http://dx.doi.org/10.1177/000348949310200901.

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The collagen composition (types I, II, and III) of the normal developing human larynx and trachea was examined by biochemical methods. Autopsy specimens of larynges with attached upper tracheal rings were obtained from 28 humans ranging in age from birth to 44 years. The specimens were randomly collected, but excluded if laryngeal disease existed. The age, sex, and cause of death were documented. Collagen is important in the growth, development, repair, regeneration, and structural and functional integrity of the laryngeal framework. A preliminary report of selected cartilaginous components of the larynx was previously published by the authors, which studied the changes in the phenotypic expression of the collagen genes in children from the newborn period to 5 years 10 months of age. The current study included all of the functioning components of the skeletal larynx and trachea. The results of biochemical examination of these tissues are reported, and the potential clinical significance of the results of the study is discussed.
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20

Woo, Jennifer A., Sonya Malekzadeh, Kelly M. Malloy, and Ellen S. Deutsch. "Are All Manikins Created Equal? A Pilot Study of Simulator Upper Airway Anatomic Fidelity." Otolaryngology–Head and Neck Surgery 156, no. 6 (October 25, 2016): 1154–57. http://dx.doi.org/10.1177/0194599816674658.

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This study evaluates the anatomic fidelity of several commercially available pediatric and adult manikins, including airway task trainers, which could be used in aerodigestive procedure training. Twenty-three experienced otolaryngologists assessed the aerodigestive anatomy of 5 adult and 5 pediatric manikins in a passive state, using rigid and flexible endoscopy. Anatomic fidelity was rated on a 5-point scale for the following: nasal cavity, nasopharynx, oral cavity, oropharynx, larynx, trachea, esophagus, and neck. Mean scores and standard deviations were tabulated for each manikin at each anatomic site. Ratings by survey participants demonstrated variation in the anatomic fidelity of the aerodigestive tract in a range of manikins. Radar chart display of the results allows comparison of manikin fidelity by anatomic site. Differences in scores may allow instructors to select manikins with the best anatomic fidelity for specific educational purposes, and they may contribute to recommendations to improve future manikin design.
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21

Calhoun, K. H., C. M. Stiernberg, F. B. Quinn, and W. D. Clark. "Teaching Indirect Mirror Laryngoscopy." Otolaryngology–Head and Neck Surgery 100, no. 1 (January 1989): 80–82. http://dx.doi.org/10.1177/019459988910000114.

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Indirect mirror laryngoscopy is difficult to learn. An anatomic model of the oropharynx and larynx is described here. This model is used to familiarize medical students with the component skills of mirror laryngoscopy. The students progress to competency at mirror laryngoscopy on patients more quickly after initial use of this model.
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22

Page, C., M. Laude, J. Peltier, L. Charlet, S. Ayache, and V. Strunski. "Anatomie du nerf laryngé externe : implications chirurgicales." Annales d'Otolaryngologie et de Chirurgie Cervico-faciale 121, no. 3 (June 2004): 148–55. http://dx.doi.org/10.1016/s0003-438x(04)95502-8.

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23

Ferlito, Alfio, Jan Olofsson, and Alessandra Rinaldo. "Clinicopathological Consultation Barrier between the Supraglottis and the Glottis: Myth or Reality?" Annals of Otology, Rhinology & Laryngology 106, no. 8 (August 1997): 716–19. http://dx.doi.org/10.1177/000348949710600820.

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Controversial opinions on the existence of a “barrier” between the supraglottic and glottic regions of the larynx are reported. Even if the two areas have different embryological derivations, there is no anatomic evidence of a “barrier” that could prevent supraglottic cancer from extending downward to the glottis. Numerous adequate pathologic studies, including whole organ sections, confirm that for advanced cancers, anatomic compartments delimiting the spread of the neoplastic process from the supraglottis to the glottis do not exist. Therefore, supraglottic laryngectomy should be performed not on the basis of embryological considerations, but on the basis of the actual extension of the neoplastic lesion.
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24

Ruaro, M. A., M. R. F. Machado, D. O. Garcia, A. R. Oliveira, F. G. G. Dias, S. P. Gomes, L. M. Leal, and T. H. C. Sasahara. "Anatomic and histologic analysis of paca larynx (Cuniculus paca, Linnaeus 1766)." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 73, no. 1 (February 2021): 155–61. http://dx.doi.org/10.1590/1678-4162-12156.

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ABSTRACT Paca (Cuniculus paca) has encouraged research as an experimental model both in the human medicine and veterinary, as well as the economic exploitation of its meat cuts, which favored its zootechnical use. There are no anatomical, microscopic descriptions and measurements of the larynx in this rodent. Eight pacas were dissected from the wild animal’s sector of the Faculty of Agricultural and Veterinary Sciences of the University of the State of São Paulo. The larynx was observed located in the ventral region of the neck, ventral to the esophagus, connecting the pharynx to the trachea, with cylindrical and irregular shape. Laryngeal cartilages (epiglottic, thyroid, cricoid and arytenoid) are interconnected and have different shapes. Thyroid showed greater length and width, compared to the others. Laryngeal cartilages were submitted to histological processing and stained with hematoxylin-eosin and Masson's trichrome. The epiglottic cartilage was stained with toluidine blue. Laryngeal cartilages thyroid, cricoid and the lower portion of the arytenoids are of hyaline origin and, in contrast, the epiglottis and the upper portion of the arytenoids are elastic. This latter cartilage demonstrated taste buds. The results will be able to auxiliate in veterinary care and as well as the conservation programs for this rodent.
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25

Bogdan, Popescu, Oancea Alina Lavinia Antoaneta, Androne Roxana Gabriela, Arjoca Elena Mihaela, and Berteșteanu Serban Victor Gabriel. "Rare Laryngeal Kaposi’s Sarcoma: Case Report and Innovative Surgical Approach." ARS Medica Tomitana 25, no. 4 (November 1, 2019): 207–13. http://dx.doi.org/10.2478/arsm-2019-0041.

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Abstract Kaposi’s sarcoma is an angioproliferative neoplasm that usually appears on the skin, but can also involve all organs and anatomic locations. The atypical manifestations of Kaposi’s sarcoma can mislead the diagnosis, which can result in a poor case management. The authors present a HIV-negative patient with Kaposi’s sarcoma with both usual and unusual locations such as the larynx, eyelids and bones. In the pre-therapeutic balance, we used NBI, which showed an intensely vascularized tumor in the larynx. The chosen method for treatment consisted in subtotal epiglotectomy performed under TransOral UltraSonic Surgery (TOUSS) approach. The use of TOUSS endoscopic surgery helped reduce the time of hospitalization, the patient did not need a nasogastric tube and was orally fed from the first postoperative day, with a better and faster functional recovery.
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Sone, Michihiko, Tsutomu Nakashima, Testuro Nagasaka, Akihide Itoh, and Noriyuki Yanagita. "Lymphoepithelioma-like carcinoma of the larynx associated with an Epstein-Barr viral infection." Otolaryngology–Head and Neck Surgery 119, no. 1 (July 1998): 134–37. http://dx.doi.org/10.1016/s0194-5998(98)70185-8.

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L ymphoepithelioma is a term used to describe undifferentiated squamous cell carcinoma variants of nasopharyngeal neoplasms (WHO type 3). Correlations between lymphoepithelioma and Epstein-Barr virus (EBV) have been investigated with serologic1 and pathologic evaluation. 2 , 3 Recently, nonnasopharyngeal neoplasms, which have morphologic features identical to those of lymphoepithelioma, called lymphoepithelioma-like carcinoma (LEC), have been reported in other anatomic sites. 4 – 10 Seven cases of laryngeal LEC have been reported in the English literature to date, but EBV has yet to be detected in laryngeal LEC. In this article, LEC in the epiglottis of the larynx is described with cellular localization of EBV-encoded immediate-early RNAs (BHLF) in the tumor cells of the larynx. This case report is the first to show laryngeal LEC associated with an EBV infection.
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27

Eliachar, Isaac, Robert J. Stegmoyer, Howard L. Levine, Edward D. Sivak, Atul C. Mehta, and Harvey M. Tucker. "Planning and Management of Long-Standing Tracheostomy." Otolaryngology–Head and Neck Surgery 97, no. 4 (October 1987): 385–90. http://dx.doi.org/10.1177/019459988709700408.

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Long-term effects of tracheostomy can include structural changes in the anterior tracheal wall and larynx as a result of pressure, friction, and deformation by the relationship between the curved cannula, the trachea, the larynx, and the upper border of the sternum. High-placed stoma, flexed cervical position, and short, obese necks are predisposing anatomic relationships, in some long-standing tracheostomies, progressive erosion of the upper anterior tracheal wall and cricoid arch is observed, often with secondary subglottic stenosis. No discussion of measures to prevent or correct these problems was found in a review of the literature. This article discusses surgical techniques to (1) prevent laryngotracheal erosion and (2) repair and reconstruct an airway that is already damaged. A superiorly based tracheostomy flap and a muscular sling are designed to buttress the tracheostomy. Results and follow-up are also reported.
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28

Gammarota, Lucio, Lucio Rucci, and Maria Bruna Borghi Cirri. "Carcinoma of the Anterior Commissure of the Larynx: I. Embryological and Anatomic Considerations." Annals of Otology, Rhinology & Laryngology 105, no. 4 (April 1996): 303–8. http://dx.doi.org/10.1177/000348949610500412.

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In this study we attempt to define the organization of the anterior region of the adult larynx, on the basis of its development. For this purpose, we have studied the development of the anterior commissure region on serial sections of human larynges from embryos, fetuses, and adults. Our findings indicate that all the structures of this region derive from a single median mesenchymal band, first evident at 7 to 8 weeks of gestation, between the lateral laminae of the thyroid cartilage. This band of mesenchyme gives rise to all the structures along the midline of the thyroid cartilage and immediately beyond, including the intermediate lamina of the thyroid cartilage, the median process, and the connective tissue that connects the latter with the conoid ligament. We provide, for the first time, evidence that Broyles' ligament (commissural tendon) derives from the dorsal part of the median process and becomes intimately connected with the surrounding structures, including the insertion fibers of the vocal muscles, from early in development. On the basis of this finding we identify an independent anterior commissure region in the adult larynx, which comprises the intermediate lamina, Broyles' ligament, the connective tissue between the Broyles' and conoid ligaments, and the insertion fibers of the vocal muscles. The interpretation of all these structures as a unified region can explain the peculiar progression pathways and evolution of commissural and cordo-commissural tumors.
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29

Anthony, James P., Peter Argenta, Philip P. Trabulsy, Richard Y. Lin, and Stephen J. Mathes. "The arterial anatomy of larynx transplantation: Microsurgical revascularization of the larynx." Clinical Anatomy 9, no. 3 (1996): 155–59. http://dx.doi.org/10.1002/(sici)1098-2353(1996)9:3<155::aid-ca3>3.0.co;2-f.

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30

Demiraslan, Yasin, Iftar Gurbuz, and Ozcan Ozgel. "Macro-Anatomic Investigation of Larynx, Trachea and Lungs in Martens (Martes Foina)." Journal of Veterinary Anatomy 10, no. 2 (October 1, 2017): 75–83. http://dx.doi.org/10.21608/jva.2017.45446.

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Sprinzl, Georg Mathias, Hans Edmund Eckel, Christian Sittel, Claus Pototschnig, and Juergen Koebke. "Morphometric measurements of the cartilaginous larynx: An anatomic correlate of laryngeal surgery." Head & Neck 21, no. 8 (November 15, 1999): 743–50. http://dx.doi.org/10.1002/(sici)1097-0347(199912)21:8<743::aid-hed10>3.0.co;2-8.

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32

Sprinzl, Georg Mathias, Hans Edmund Eckel, Christian Sittel, Claus Pototschnig, and Juergen Koebke. "Morphometric measurements of the cartilaginous larynx: An anatomic correlate of laryngeal surgery." Head & Neck 21, no. 8 (December 1999): 743–50. http://dx.doi.org/10.1002/(sici)1097-0347(199912)21:8<743::aid-hed10>3.3.co;2-#.

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33

Mohamed, A. S. R., B. H. Pham, J. A. Messer, W. H. Morrison, M. Zafereo, A. C. Hessel, S. Lai, et al. "Identification of Anatomic Correlates of Failure in Patients With T4a Larynx Cancer." International Journal of Radiation Oncology*Biology*Physics 94, no. 4 (March 2016): 896. http://dx.doi.org/10.1016/j.ijrobp.2015.12.099.

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34

Mohamed, A. S. R., B. H. Pham, J. A. Messer, W. H. Morrison, M. Zafereo, A. C. Hessel, S. Y. Lai, et al. "Identification of Anatomic Correlates of Failure in Patients With T4a Larynx Cancer." International Journal of Radiation Oncology*Biology*Physics 96, no. 2 (October 2016): E343. http://dx.doi.org/10.1016/j.ijrobp.2016.06.1488.

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35

Kovalenko, Yu V., A. S. Tolstokorov, S. N. Kotov, G. A. Manakhov, and E. N. Kurochkina. "Application of the original method of intra-operative electrophysiological stimulation of recurrent laryngeal nerve with surgical interventions on the neck organs." Grekov's Bulletin of Surgery 179, no. 3 (August 3, 2020): 19–24. http://dx.doi.org/10.24884/0042-4625-2020-179-3-19-24.

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The OBJECTIVE was the reduction in the frequency of specific complications of surgical treatment of patients with pathology of the thyroid and parathyroid glands using the original method of monitoring the neuro-functional activity of the recurrent laryngeal nerve.METHODS AND MATERIALS. The research was conducted in two stages. At the first stage, the object of the topographic-anatomical study was 50 male and female corpses. The research, based on the fixed material, was focused upon the study of the anatomic special features of recurrent laryngeal nerves, their relations with neighboring structures, the study of peculiarities of recurrent laryngeal nerve syntopy and its neighboring structures to find the least traumatic way of incision during electroneurophysiological monitoring of activity. At the second stage, the object of the study was 60 patients with a benign pathology of the thyroid gland, who were operated on with the use of the original method of intra-operational visualization and control method over neuro-functional activity of recurrent laryngeal nerve.RESULTS. The frequency of the three different variants of topographic-anatomical position of recurrent laryngeal nerve depends on the side of the body. The safest, stable and the fastest one to be found is the left recurrent laryngeal nerve. Postoperative unilateral paresis of the larynx, diagnosed in 4 of 60 patients, is regarded as postischemic. Two-sided paresis of the larynx was diagnosed in 1 patient.CONCLUSION. This method allows to minimize the development of severe intraoperative complications, to reduce the frequency of postoperative paralysis and paresis of the larynx. Intra-operative visualization of recurrent laryngeal nerves is especially necessary during the repeated surgeries with postoperative scar transformations with wrong syntopy of neck organs and vascular-nerve structures, which makes it possible to minimize the number of postoperative paralyses and paresis of larynx and to get positive effect without carrying out the intubation of trachea among patients with postoperative paralysis of larynx or stenosis, and to avoid more serious damage of larynx or trachea in case of intubation.
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Rucci, Lucio, Paolo Romagnoli, Corso Bocciolini, and Jan Olofsson. "Risk Factors and Prognosis of Anterior Commissure versus Posterior Commissure T1-T2 Glottic Cancer." Annals of Otology, Rhinology & Laryngology 112, no. 3 (March 2003): 223–29. http://dx.doi.org/10.1177/000348940311200306.

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For better understanding of the causation and behavior of T1–T2 commissural glottic laryngeal tumors, we retrospectively analyzed risk factors and outcome related to T class and type of therapy for tumors involving the anterior (184 cases) or the posterior (60 cases) commissure. The patients' smoking habits and alcohol consumption were similar, regardless of involved subsite. The disease-free interval was longer after surgery than after radiotherapy. The survival rates after recovery upon relapse were similar among subsites, T classes, and types of therapy. In anterior commissure tumors, the larynx remained preserved more frequently after partial laryngeal resection than after radiotherapy, and was more frequently preserved the lower the T class. In posterior commissure tumors, larynx preservation was less frequent and apparently independent of type of therapy or T class. In conclusion, smoking and alcohol consumption play similar pathogenetic roles in either subsite; partial laryngeal resection gave a higher rate of laryngeal preservation than did radiotherapy; and anatomic peculiarities of the subsites influence tumor behavior.
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Hussain, Raza, Asif Loya, Arif Jamshed, and Adeel Haider Tirmazi. "Synovial Cell Sarcoma of the Hypopharynx." International Journal of Head and Neck Surgery 4, no. 2 (2013): 86–88. http://dx.doi.org/10.5005/jp-journals-10001-1146.

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ABSTRACT Synovial sarcomas of head and neck are very rare and account for only 3% of all sarcomas. Approximately 5% of synovial sarcomas arise in the head and neck region and hypopharynx and larynx are the most and least often affected anatomic sites respectively. We describe a rare case of primary hypopharyngeal synovial sarcoma in a young adult. How to cite this article Jamshed A, Loya A, Tirmazi AH, Hussain R. Synovial Cell Sarcoma of the Hypopharynx. Int J Head Neck Surg 2013;4(2):86-88.
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Jeremy, Dan Vos, David Harley, Akihird Katada, Brad Swelstad, Shashidhar Kusuma, and David L. Zealear. "Anatomic Effect of Electrical Stimulation on the Reinnervation of the Paralyzed Canine Larynx." Otolaryngology–Head and Neck Surgery 131, no. 2 (August 2004): P204—P205. http://dx.doi.org/10.1016/j.otohns.2004.06.385.

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39

Thompson, Lester D. R., and Francis H. Gannon. "Chondrosarcoma of the Larynx." American Journal of Surgical Pathology 26, no. 7 (July 2002): 836–51. http://dx.doi.org/10.1097/00000478-200207000-00002.

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40

Henick, David H. "Three-Dimensional Analysis of Murine Laryngeal Development." Annals of Otology, Rhinology & Laryngology 102, no. 3_suppl (March 1993): 3–24. http://dx.doi.org/10.1177/00034894931020s301.

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This study defines the critical stages in the prenatal development of the mouse larynx. Three-dimensional computer-generated solid model reconstructions display the changing anatomic relationships during laryngeal development from the earliest respiratory primordium to the mature laryngeal vestibule. These reconstructions demonstrate that the laryngeal vestibule forms as a result of a cephalocaudal separation of the epithelial lamina, thereby establishing communication between the laryngeal cecum and the pharyngoglottic duct. These results support the hypothesis that the cause of congenital supraglottic and glottic malformations is an incomplete separation of this epithelial lamina. The infraglottic lumen remains patent during laryngeal development. Continued lengthening of the foregut between the infraglottis and the carina forms the trachea. This is contrary to the 19th-century concept of an ascending tracheoesophageal septum. Formation of the laryngeal cartilages, muscles, and innervation is portrayed by the reconstructions; with minor variations, they correlate closely with earlier wax reconstructions of human laryngeal development. Future research with this animal model can provide additional insights into the complex mechanisms involved in congenital malformations of the larynx.
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Stomnaroska, Orhideja, Goran Kocovski, Panche Zdravkovski, Boro Ilievski, Rubens Jovanovic, and Gordana Petrusevska. "Large Neck Teratoma in a Newborn with Respiratory Distress Syndrome." PRILOZI 42, no. 1 (April 1, 2021): 105–8. http://dx.doi.org/10.2478/prilozi-2021-0009.

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Abstract Neonatal tumours in the neck region are a rare finding. Teratomas typically comprise all three germ cell layers with tissues usually foreign to the anatomic site of origin. Head and neck teratomas account a smaller part of congenital teratomas. They can cause major airway obstruction due to the external compression that oropharyngeal or neck masses produce. In addition, there can be an intrinsic lesion in the larynx or trachea. We describe a premature, 30-gestational week-old newborn with large subcutaneous neck mass. Pre-delivery ultrasound showed heterogeneous tumor structure and displaced larynx. The intubation was successful. The newborn developed respiratory distress syndrome immediately after birth which rendered the surgical removal of the neck tumor impossible. An autopsy was done, and the histopathology revealed mature teratoma comprising muscle, brain, salivary and pulmonary tissues, as well as well-developed hyaline membranes in the alveoli. The combination of the respiratory distress syndrome and the neck tumor compression proved fatal. Prenatal diagnosis, therapeutic options and ex utero intrapartum treatment (EXIT) procedures are discussed for the diagnosis and management of this very rare tumor.
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Battifora, Hector. "Benign Paraganglioma of the Larynx." Applied Immunohistochemistry 6, no. 2 (1998): 113–14. http://dx.doi.org/10.1097/00022744-199806000-00011.

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43

Maksimovic, R. M., B. A. Banko, and J. P. Milovanovic. "Imaging of larynx: Diagnostic value of computed tomography and magnetic resonance imaging." Acta chirurgica Iugoslavica 56, no. 3 (2009): 39–44. http://dx.doi.org/10.2298/aci0903039m.

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Computed tomography (CT) and magnetic resonance imaging (MRI) are enabling more precise diagnosis and treatment planning in patients with diseases of the larynx. The aim of this article is to describe the role of these methods in assessment of the laringeal diseases and key local anatomic characteristics important for spread of the disease. CT and MRI have a valuable contribution to the staging of the tumors due to the possibility to show the relationship to the ventricular complex, involvement of the subumucosal spaces, defining craniocaudal and anterposterior extension, laringeal cartilage invasion, as well as regional lymph node metastases.
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44

Holt, G. Richard, Thomas B. Aufdemorte, and Peter J. Sheridan. "Estrogen Receptor in the Larynx of the Aged Baboon (Papio Cynocephalus)." Annals of Otology, Rhinology & Laryngology 95, no. 6 (November 1986): 608–17. http://dx.doi.org/10.1177/000348948609500614.

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Using autoradiographic techniques, tritiated estrogen-receptor complex intranuclear labeling was identified in certain laryngeal tissues of four aged female baboons; no complex labeling was found in the control animal. Three significant findings were felt to be derived from this study. One, surface epithelium of the larynx had essentially no estrogen-receptor activity. Two, all tissues of mesenchymal origin, especially lamina propria, muscle, dense connective tissue, and fat had consistently high levels of nuclear localization of the labeled estrogen. The binding affinity seemed to be the highest at the anterior commissure and the immediate anterior subglottic space. Three, there was a high level of receptor binding in laryngeal cartilage and perichondrium. Since the activated hormone-receptor complex modulates gene expression to alter the amount of mRNA, sex steroids have a direct regulatory effect upon the target cell and, perhaps through an induction process, can exert an indirect effect upon adjacent tissues. It is postulated that since the larynx is a sexually dimorphic organ, the sex steroids and their receptors may play a role in altered phonation during aging and possibly in the development of laryngeal neoplasms and other diseases. Therefore, hormonal manipulation may play a future role in the therapy of laryngeal diseases. This study represents the first demonstration of estrogen receptors by specific anatomic location in the primate larynx with significant localization in the mesenchymal tissues but not in the epithelial tissues.
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Chrysikos, Dimosthenis, Markos Sgantzos, John Tsiaoussis, George Noussios, Theodore Troupis, Vassilios Protogerou, Eleftherios Spartalis, Tania Triantafyllou, and Theodoros Mariolis-Sapsakos. "Non-Recurrent Right Laryngeal Nerve: a Rare Anatomic Variation Encountered During a Total Thyroidectomy." Acta Medica (Hradec Kralove, Czech Republic) 62, no. 2 (2019): 69–71. http://dx.doi.org/10.14712/18059694.2019.105.

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The non-recurrent laryngeal nerve (nRLN) is a rare anatomic variation that every head and neck surgeon must be aware of, in order to avoid intraoperative injury which leads to postoperative morbidity. We are reporting a case of a nRLN in a 47 year old female patient with medullary thyroid carcinoma who was surgically treated with total thyroidectomy and lymph node dissection. Both two inferior laryngeal nerves were identified, fully exposed and preserved along their cervical courses. However, we found that the right inferior laryngeal nerve was non-recurrent and directly arised from the cervical vagal trunk, entered the larynx after a short transverse course and parallel to the inferior thyroid artery. The safety of thyroid operations is dependent on high index of suspicion, meticulous identification and dissection of laryngeal nerves either recurrent or non-recurrent. This leads to minimum risk of iatrogenic damage of the nerves. Complete knowledge of the anatomy of these neural structures, including all their anatomic variations is of paramount importance.
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&NA;. "“Early” carcinoma of the larynx." Advances in Anatomic Pathology 6, no. 5 (September 1999): 297. http://dx.doi.org/10.1097/00125480-199909000-00012.

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47

Starostina, S. V. "Analysis of degree of incidence of small anatomic anomalies of larynx among dysphonia patients." Medical Council, no. 18 (January 1, 2016): 72–75. http://dx.doi.org/10.21518/2079-701x-2016-18-72-75.

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48

Inagi, Katsuhide, Edward Schultz, and Charles N. Ford. "An Anatomic Study of the Rat Larynx: Establishing the Rat Model for Neuromuscular Function." Otolaryngology–Head and Neck Surgery 118, no. 1 (January 1998): 74–81. http://dx.doi.org/10.1016/s0194-5998(98)70378-x.

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49

Saeseow, Patchareeporn, Akkararat Sartsungnern, Supaporn Srirompotong, Kowit Chaisiwamongkol, and Thanarat Chantaupalee. "Anatomic direction of entry for botulinum toxin injection to treat the adductor spasmodic dysphonia in Thais." Asian Biomedicine 4, no. 4 (August 1, 2010): 641–44. http://dx.doi.org/10.2478/abm-2010-0082.

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Abstract Background: Botulinum toxin injections into the thyroarytenoid (TA) muscle of the larynx is the most popular treatment for adductor spasmodic dysphonia. Injection is usually done by percutaneous transcricothyroid membrane with either electromyography (EMG) or fiberoptic laryngoscopy (FOL) to verify placement of the needle within the TA muscle. This procedure requires a working knowledge of three-dimensional anatomy of the larynx to establish the direction for the accurate placement of the needle. Objective: Find out the appropriate angles and depth of the needle for placement of percutaneous transcricothyroid membrane method of botulinum toxin injection by means of studying the larynges of Thai cadavers. Methods: The descriptive study was performed in 45 Thai freshly thawed cadavers. The angle of the needle from midline sagittal plane, the angle in superior relation to tracheal plane, and the depth from midline cricothyroid (CT) membrane to midlength of TA muscle were measured from the two views of photographs, anteroposterior and lateral. Results: The mean angle of 24.2±6.76° (mean±SD) from the midline sagittal plane in male and 24.9±7.6° in female were worked out. A mean angle in superior relation to the tracheal plane was 47.7±7.8° and 51.4±9.6° in male and female, respectively. The mean depth was 1.7±0.2 and 1.4±0.1 cm in male and female, respectively. Conclusion: The mean angles and depth of the needle insertion from the midline of CT membrane to the center of TA muscle in Thai laryngeal specimens were evaluated. These values were different from the studies in Caucasians, but it could provide a direct relationship to the build of the races. This knowledge may help laryngologists do this procedure more accurately with better outcome, especially in hospitals that have no EMG or FOL guide.
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Woodruff, James M., Andrew G. Huvos, Robert A. Erlandson, Jatin P. Shah, and Frank P. Gerold. "Neuroendocrine carcinomas of the larynx." American Journal of Surgical Pathology 9, no. 11 (November 1985): 771–90. http://dx.doi.org/10.1097/00000478-198511000-00001.

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