Relevant bibliographies by topics / Lasb

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Academic literature on the topic 'Lasb'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 April 2022

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Journal articles on the topic "Lasb"

1

Storey, Douglas G., Eva E. Ujack, Harvey R. Rabin, and Ian Mitchell. "Pseudomonas aeruginosa lasRTranscription Correlates with the Transcription of lasA,lasB, and toxA in Chronic Lung Infections Associated with Cystic Fibrosis." Infection and Immunity 66, no. 6 (June 1, 1998): 2521–28. http://dx.doi.org/10.1128/iai.66.6.2521-2528.1998.

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ABSTRACT The role of Pseudomonas aeruginosa quorum-sensing systems in the lung infections associated with cystic fibrosis (CF) has not been examined. The purpose of this study was to determine if genes regulated by the LasR-LasI quorum-sensing system were coordinately regulated by the P. aeruginosa populations during the lung infections associated with CF. We also wanted to ascertain if there was a relationship between the expression of lasR, a transcriptional regulator, and some P. aeruginosa virulence factors during these infections. We extracted RNAs from the bacterial populations of 131 sputa taken from 23 CF patients. These RNAs were blotted and hybridized with probes to P. aeruginosa lasA,lasB, and toxA. The hybridization signals from each probe were ranked, and the rankings were analyzed by a Spearman rank correlation to determine if there was an association between the population transcript accumulations for the three genes. The correlations between the transcript accumulation patterns of pairs of the genes suggested that lasA, lasB, andtoxA might be coordinately regulated during CF lung infections. To determine if this coordinate regulation might be due to regulation by LasR, we probed RNAs, extracted from 84 sputa, with thelasR, lasA, lasB, toxA, and algD probes. Statistical analysis indicated thatlasR transcript accumulation correlated tolasA, lasB, toxA, andalgD transcript accumulations. These results indicated thatlasR may at least partially regulate or be coordinately regulated with lasA, lasB, toxA, and algD during the lung infections associated with CF. These results also suggested that the LasR-LasI quorum-sensing system may control the expression of at least some virulence factors in the lungs of patients with CF.
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Kong, Kok-Fai, Suriya Ravi Jayawardena, Shalaka Dayaram Indulkar, Aimee del Puerto, Chong-Lek Koh, Niels Høiby, and Kalai Mathee. "Pseudomonas aeruginosa AmpR Is a Global Transcriptional Factor That Regulates Expression of AmpC and PoxB β-Lactamases, Proteases, Quorum Sensing, and Other Virulence Factors." Antimicrobial Agents and Chemotherapy 49, no. 11 (November 2005): 4567–75. http://dx.doi.org/10.1128/aac.49.11.4567-4575.2005.

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ABSTRACT In members of the family Enterobacteriaceae, ampC, which encodes a β-lactamase, is regulated by an upstream, divergently transcribed gene, ampR. However, in Pseudomonas aeruginosa, the regulation of ampC is not understood. In this study, we compared the characteristics of a P. aeruginosa ampR mutant, PAOampR, with that of an isogenic ampR + parent. The ampR mutation greatly altered AmpC production. In the absence of antibiotic, PAOampR expressed increased basal β-lactamase levels. However, this increase was not followed by a concomitant increase in the P ampC promoter activity. The discrepancy in protein and transcription analyses led us to discover the presence of another chromosomal AmpR-regulated β-lactamase, PoxB. We found that the expression of P. aeruginosa ampR greatly altered the β-lactamase production from ampC and poxB in Escherichia coli: it up-regulated AmpC but down-regulated PoxB activities. In addition, the constitutive P ampR promoter activity in PAOampR indicated that AmpR did not autoregulate in the absence or presence of inducers. We further demonstrated that AmpR is a global regulator because the strain carrying the ampR mutation produced higher levels of pyocyanin and LasA protease and lower levels of LasB elastase than the wild-type strain. The increase in LasA levels was positively correlated with the P lasA , P lasI , and P lasR expression. The reduction in the LasB activity was positively correlated with the P rhlR expression. Thus, AmpR plays a dual role, positively regulating the ampC, lasB, and rhlR expression levels and negatively regulating the poxB, lasA, lasI, and lasR expression levels.
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Anderson, Ronda M., Chad A. Zimprich, and Lynn Rust. "A Second Operator Is Involved in Pseudomonas aeruginosa Elastase (lasB) Activation." Journal of Bacteriology 181, no. 20 (October 15, 1999): 6264–70. http://dx.doi.org/10.1128/jb.181.20.6264-6270.1999.

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ABSTRACT Pseudomonas aeruginosa LasB elastase gene (lasB) transcription is controlled by the two-component quorum-sensing system of LasR, and the autoinducer, 3OC12-HSL (N-3-[oxododecanoyl]homoserine lactone). LasR and 3OC12-HSL-mediated lasBactivation requires a functional operator sequence (OP1) in thelasB promoter region. Optimal activation oflasB, however, requires a second sequence of 70% identity to OP1, named OP2, located 43 bp upstream of OP1. In this study, we used sequence substitutions and insertion mutations inlasBp-lacZ fusion plasmids to explore the role of OP2 in lasB activation. Our results demonstrate that (i) OP1 and OP2 synergistically mediate lasB activation; (ii) OP2, like OP1, responds to LasR and 3OC12-HSL; and (iii) the putative autoinducer-binding domain of LasR is not required for synergistic activation from OP1 and OP2.
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Cowell, Brigitte A., Sally S. Twining, Jeffrey A. Hobden, Mary S. F. Kwong, and Suzanne M. J. Fleiszig. "Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells." Microbiology 149, no. 8 (August 1, 2003): 2291–99. http://dx.doi.org/10.1099/mic.0.26280-0.

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Pseudomonas aeruginosa is an opportunistic bacterial pathogen implicated in a variety of devastating conditions. Its flexibility as a pathogen is attributed to a myriad of virulence factors and regulatory elements that respond to prevailing environmental conditions. ExoS and ExoT are type III secreted effector proteins, regulated by the transcriptional activator ExsA, that can inhibit invasion of epithelial cells by cytotoxic strains of P. aeruginosa. This study sought to understand why invasive strains, which can secrete both ExoS and ExoT, still invade epithelial cells. The results showed that LasA and elastase (LasB), which are regulated by the Las and Rhl quorum-sensing systems, modulated P. aeruginosa invasion. Mutation of lasA and/or lasB reduced P. aeruginosa invasion, which was not fully restored by extracellularly added LasB, P. aeruginosa conditioned medium containing LasA and LasB, or EGTA pretreatment of cells. This indicated that protease effects on invasion involved factors additional to tight junction disruption and subsequent alterations to cell polarity. Upon mutation of lasA and/or lasB, steady-state levels of ExoS and ExoT were increased in culture medium of P. aeruginosa grown under conditions stimulatory for these toxins. The increase in ExoS was significantly correlated with reduced invasion. In vitro experiments showed that purified LasB degraded recombinant ExoS. Taken together, these studies suggest a mechanism by which invasive strains can synthesize inhibitors of invasion, ExoS and ExoT, yet still invade epithelial cells. By this mechanism, LasA and LasB decrease the levels of the toxins directly or indirectly, and thus reduce inhibition of invasion.
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Jude, Florence, Thilo Köhler, Pavel Branny, Karl Perron, Matthias P. Mayer, Rachel Comte, and Christian van Delden. "Posttranscriptional Control of Quorum-Sensing-Dependent Virulence Genes by DksA in Pseudomonas aeruginosa." Journal of Bacteriology 185, no. 12 (June 15, 2003): 3558–66. http://dx.doi.org/10.1128/jb.185.12.3558-3566.2003.

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ABSTRACT Pseudomonas aeruginosa controls the secretion of extracellular virulence factors, including rhamnolipids and LasB elastase, by the las and rhl quorum-sensing systems. Here, we mutated the dksA gene of P. aeruginosa by insertion of an Ω-Hg cassette. The mutant displayed growth rates similar to that of the wild type in rich medium but was impaired in growth in defined minimal medium. Production of rhamnolipids and LasB elastase by the dksA mutant was only 4 and 10%, respectively, of wild-type levels. These defects could be partially complemented by introduction of the plasmid-encoded dksA genes from P. aeruginosa or Escherichia coli. In the dksA mutant, the expression of rhlI was increased early during exponential growth, but expression of other quorum-sensing regulator genes—lasR, lasI, and rhlR—was not affected. Although the transcription of the lasB and rhlAB genes was comparable between the dksA mutant and the wild-type strain in peptone tryptic soy broth medium, we observed reduced translation of both genes in the dksA mutant. Similarly, we found that full translation of lasB and rhlAB genes in E. coli also requires the dksA gene. DksA is therefore a novel regulator involved in the posttranscriptional control of extracellular virulence factor production in P. aeruginosa.
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Ishida, Takenori, Tsukasa Ikeda, Noboru Takiguchi, Akio Kuroda, Hisao Ohtake, and Junichi Kato. "Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides." Applied and Environmental Microbiology 73, no. 10 (March 16, 2007): 3183–88. http://dx.doi.org/10.1128/aem.02233-06.

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ABSTRACT N-Octanoyl cyclopentylamide (C8-CPA) was found to moderately inhibit quorum sensing in Pseudomonas aeruginosa PAO1. To obtain more powerful inhibitors, a series of structural analogs of C8-CPA were synthesized and examined for their ability to inhibit quorum sensing in P. aeruginosa PAO1. The lasB-lacZ and rhlA-lacZ reporter assays revealed that the chain length and the ring structure were critical for C8-CPA analogs to inhibit quorum sensing. N-Decanoyl cyclopentylamide (C10-CPA) was found to be the strongest inhibitor, and its concentrations required for half-maximal inhibition for lasB-lacZ and rhlA-lacZ expression were 80 and 90 μM, respectively. C10-CPA also inhibited production of virulence factors, including elastase, pyocyanin, and rhamnolipid, and biofilm formation without affecting growth of P. aeruginosa PAO1. C10-CPA inhibited induction of both lasI-lacZ by N-(3-oxododecanoyl)-l-homoserine lactone (PAI1) and rhlA-lacZ by N-butanoyl-l-homoserine lactone (PAI2) in the lasI rhlI mutant of P. aeruginosa PAO1, indicating that C10-CPA interferes with the las and rhl quorum-sensing systems via inhibiting interaction between their response regulators (LasR and RhlR) and autoinducers.
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McKnight, Susan L., Barbara H. Iglewski, and Everett C. Pesci. "The Pseudomonas Quinolone Signal Regulates rhl Quorum Sensing in Pseudomonas aeruginosa." Journal of Bacteriology 182, no. 10 (May 15, 2000): 2702–8. http://dx.doi.org/10.1128/jb.182.10.2702-2708.2000.

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ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa uses intercellular signals to control the density-dependent expression of many virulence factors. The las and rhlquorum-sensing systems function, respectively, through the autoinducersN-(3-oxododecanoyl)-l-homoserine lactone andN-butyryl-l-homoserine lactone (C4-HSL), which are known to positively regulate the transcription of the elastase-encoding gene, lasB. Recently, we reported that a second type of intercellular signal is involved in lasB induction. This signal was identified as 2-heptyl-3-hydroxy-4-quinolone and designated thePseudomonas quinolone signal (PQS). PQS was determined to be part of the quorum-sensing hierarchy since its production and bioactivity depended on the las and rhlquorum-sensing systems, respectively. In order to define the role of PQS in the P. aeruginosa quorum-sensing cascade,lacZ gene fusions were used to determine the effect of PQS on the transcription of the quorum-sensing system geneslasR, lasI, rhlR, andrhlI. We found that in P. aeruginosa, PQS caused a major induction of rhlI′-lacZ and had lesser effects on the transcription of lasR′-lacZ andrhlR′-lacZ. We also observed that the transcription of bothrhlI′-lacZ and lasB′-lacZ was cooperatively effected by C4-HSL and PQS. Additionally, we present data indicating that PQS was not produced maximally until cultures reached the late stationary phase of growth. Taken together, our results imply that PQS acts as a link between the las and rhlquorum-sensing systems and that this signal is not involved in sensing cell density.
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Cabrol, Ségolène, Anne Olliver, Gerald B. Pier, Antoine Andremont, and Raymond Ruimy. "Transcription of Quorum-Sensing System Genes inClinical and Environmental Isolates of Pseudomonasaeruginosa." Journal of Bacteriology 185, no. 24 (December 15, 2003): 7222–30. http://dx.doi.org/10.1128/jb.185.24.7222-7230.2003.

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ABSTRACT Quorum sensing (QS)-based transcriptional responses in Pseudomonas aeruginosa have been defined on the basis of increases in transcript levels of QS-controlled genes such as lasB and aprA following the hierarchical transcriptional increases of central controllers such as the lasR gene. These increases occur at high bacterial concentrations such as early-stationary-phase growth in vitro. However, the extent to which the increases occur in a variety of clinical and environmental isolates has not been determined nor is there extensive information on allelic variation in lasR genes. An analysis of the sequences of the lasR gene among 66 clinical and environmental isolates showed that 81% have a sequence either identical to that of strain PAO1 or with a silent mutation, 15% have nucleotide changes resulting in amino acid changes, and 5% have an insertion sequence in the lasR gene. Using real-time PCR to quantify transcript levels of lasR, lasB, and aprA in the early log and early stationary phases among 35 isolates from bacteremia and pneumonia cases and the environment, we found most (33 of 35) strains had increases in lasR transcripts in early stationary phase but with a very wide range of final transcript levels per cell. There was a strong correlation (r 2 = 0.84) between early-log- and early-stationary-phase transcript levels in all strains, but this finding remained true only for the 50% of strains above the median level of lasR found in early log phase. There were significant (P < 0.05) but weak-to-modest correlations of lasR transcript levels with aprA (r2= 0.2) and lasB (r 2 = 0.5) transcript levels, but again this correlation occurred only in the 50% of P. aeruginosa strains with the highest levels of lasR transcripts in early stationary phase. There were no differences in distribution of lasR alleles among the bacteremia, pneumonia, or environmental isolates. Overall, only about 50% of P. aeruginosa strains from clinical and environmental sources show a lasR-dependent increase in the transcription of aprA and lasB genes, indicating that for about 50% of clinical isolates this regulatory system may not play a significant role in pathogenesis.
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Zhao, Chaoyue, Hongda Zheng, Liman Zhou, Hongrui Ji, Lu Zhao, Wengong Yu, and Qianhong Gong. "Falcarindiol Isolated from Notopterygium incisum Inhibits the Quorum Sensing of Pseudomonas aeruginosa." Molecules 26, no. 19 (September 29, 2021): 5896. http://dx.doi.org/10.3390/molecules26195896.

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Quorum sensing (QS) is employed by the opportunistic pathogen Pseudomonas aeruginosa to regulate physiological behaviors and virulence. QS inhibitors (QSIs) are potential anti-virulence agents for the therapy of P. aeruginosa infection. During the screening for QSIs from Chinese herbal medicines, falcarindiol (the major constituent of Notopterygium incisum) exhibited QS inhibitory activity. The subinhibitory concentration of falcarindiol exerted significant inhibitory effects on the formation of biofilm and the production of virulence factors such as elastase, pyocyanin, and rhamnolipid. The mRNA expression of QS-related genes (lasB, phzH, rhlA, lasI, rhlI, pqsA, and rhlR) was downregulated by falcarindiol while that of lasR was not affected by falcarindiol. The transcriptional activation of the lasI promoter was inhibited by falcarindiol in the P. aeruginosa QSIS-lasI selector. Further experiments confirmed that falcarindiol inhibited the las system using the reporter strain Escherichia coli MG4/pKDT17. Electrophoretic mobility shift assay (EMSA) showed that falcarindiol inhibited the binding of the transcription factor LasR and the lasI promoter region. Molecular docking showed that falcarindiol interacted with the Tyr47 residue, leading to LasR instability. The decrease of LasR-mediated transcriptional activation was responsible for the reduction of downstream gene expression, which further inhibited virulence production. The inhibition mechanism of falcarindiol to LasR provides a theoretical basis for its medicinal application.
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Hamood, Abdul N., and John Griswold. "DNA hybridization analysis of thePseudomonas aeruginosaelastase gene [lasB) from different clinical isolates." Canadian Journal of Microbiology 41, no. 10 (October 1, 1995): 910–17. http://dx.doi.org/10.1139/m95-125.

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Pseudomonas aeruginosa produces several extracellular virulence factors including elastase (which is encoded by lasB). Recently, we examined several clinical isolates of P. aeruginosa for the production of toxin A, elastase, exoenzyme S, and phospholipase C. Although the majority of the isolates produced a high level of elastase, a few isolates produced either very low or no detectable elastase. In this study, we tried to determine the presence of restriction site heterogeneity within lasB from these isolates and the possible correlation between such heterogeneity and the observed variation in elastase production. Chromosomal DNA from the isolates was digested with different restriction enzymes and examined by Southern blot hybridization experiments using two lasB probes. One lasB probe covers 636 bp of lasB structural gene while the other covers 240 bp of the lasB upstream region. Chromosomal DNA from P. aeruginosa PAO1 and PA103 was used as controls. Results indicate that chromosomal DNA from all isolates hybridized to both lasB probes. Depending on the restriction enzyme used for DNA digestion, lasB from 3 to 12% of the isolates showed different patterns of hybridization with the lasB structural gene probe. However, no difference in the hybridization pattern was seen with the lasB upstream probe. With the exception of one isolate, hybridization of genomic DNA from different isolates (with both probes) produced a single hybridization band. In that isolate, an additional hybridization band was detected. Immunoblotting experiments confirmed that elastase protein is not produced by 6 out of 67 isolates. However, lasB from four of these elastase-deficient strains showed no difference in the hybridization pattern with either lasB probe. These results suggest that (i) lasB is present as a single copy in all but one isolate; (ii) with the exception of one, the lasB upstream region from different P. aeruginosa isolates contains no restriction site polymorphism; (iii) the observed heterogeneity within lasB structural genes is limited; and (iv) variations in the hybridization patterns of lasB from different isolates do not correlate with the differences between these isolates in elastase production.Key words: Pseudomonas aeruginosa, clinical isolates, DNA hybridization, elastase, lasB.
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Dissertations / Theses on the topic "Lasb"

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Bastaert, Fabien. "La sécrétion de LasB par Pseudomonas aeruginosa, un mécanisme de défense efficace pour échapper aux macrophages alvéolaires de l'hôte." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC055.

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Pseudomonas aeruginosa (P. A) est, à cause de sa virulence, un des agents pathogènes les plus connus notamment dans les cas d'infections nosocomiales et dans la mucoviscidose où la morbidité et la mortalité des patients sont engagées. Si la capacité d'antibiorésistance de P. A explique cette réalité, il ne faut cependant pas ignorer la diversité des toxines qu'elle produit. Parmi celles qui font sa force, la pertinence des facteurs de virulence sécrétés et injectés par le système de sécrétion du type III (SSTIII) est plus qu'avérée, a contrario de ceux sécrétés par le SSTII. Il existe bien une vaste littérature sur le rôle de LasB in vitro, mais rare sont les études mentionnant son action directe sur les cellules myéloïdes. Pour les enrichir, nous avons justement inscrit ce manuscrit dans cette rareté et finalement, en plus de démontrer que LasB est bien la toxine majeure sécrétée par le SSTII, nous montrons pour la première fois qu'elle est capable d'agir de manière directe sur les macrophages alvéolaires (MA). En effet, au travers de nos travaux, LasB s'est révélée être une toxine ciblant et inhibant l'activité bactériolytique des MA in vivo, ex vivo et in vitro et ce, dans des conditions non-opsoniques comme peuvent l'être celles des alvéoles naïves et saines. Toutefois, même si les technologies utilisées ont été nombreuses, le mécanisme sous-jacent à cette action directe de LasB sur les MA reste une énigme. Malgré cela, notre étude apporte de nouveaux éléments permettant de comprendre pourquoi chez des individus immunologiquement sensibles P. A, en échappant à la réponse de l'hôte, s'implante précocement puis irrémédiablement dans leur poumon
Because of its virulence Pseudomonas aeruginosa (P. A) is one of the main pathogens causing numerous cases of nosocomial infections. It is also present in the airways of cystic fibrosis patients in which it is associated with an increased morbidity and mortality. Although this can partly be explained by its antibiotic resistance, the diversity of toxins it produces should not be ignored. Among those, the relevance of virulence factors secreted and injected through the type III secretion system (TIIISS) is undeniable, however those secreted by the TIISS are underestimated. There is indeed a vast literature on the role of the elastase LasB in vitro, but studies indicating its direct action on myeloid cells are rare. To enrich them, we have registered our manuscript in this rarity and finally, in addition to demonstrating that LasB is the major toxin secreted by the TIISS, we show for die first time that LasB is able to act directly on alveolar macrophages (AM). Indeed, throughout our work, LasB bas proved to be a toxin targeting and inhibiting the bacteriolytic activity of AM in vivo, ex vivo and in vitro and in non-opsonic conditions as can those of naive and healthy alveoli. Although different pathways using numerous techniques have been investigated, the underlying mechanism for this direct action of LasB on AM remains unclear. Nevertheless, our study provides new evidence that contributes to understand why in immunologically susceptible individuals, P. A is setting up early and irrevocably in their lung at least partly by escaping the host's immune response
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Walter, Isabell [Verfasser]. "Anti-infectives for novel targets : development of inhibitors targeting CYP121 from mycobacterium tuberculosis and LasB from pseudomonas aeruginosa / Isabell Walter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1236897056/34.

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Camberlein, Virgyl. "Target-guided synthesis of metalloenzymes ligands with therapeutic applications." Thesis, Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS004.

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La synthèse guidée par la cible de ligands protéiques est une stratégie innovante pour découvrir des composés bioactifs. En particulier, la Kinetic Target-Guided Synthesis (KTGS) and the Dynamic Combinatorial Chemistry (DCC) ont permis, ces dernières années, de découvrir des ligands originaux pour des cibles thérapeutiques mal explorées, ce qui a permis de lancer des projets de découverte de médicaments. Ce projet de thèse vise à utiliser la KTGS pour découvrir, puis optimiser des ligands de deux classes de métalloenzymes que sont les aminopeptidases du réticulum endoplasmiques (ERAP) et l’élastase LasB de la bactérie Pseudomonas aeruginosa. Les ERAPs (1 et 2) participent au processus de maturation des antigènes. Ces enzymes clivent les précurseurs peptidiques en peptides antigéniques matures afin que ceux-ci disposent d’une taille optimale pour leur complexation au complexe majeur d’histocompatibilité de classe I et ainsi initient ou non la réponse immunitaire adaptative. Les niveaux d’expression de ces protéases ainsi que des polymorphismes d’un seul nucléotide ont été associé au développement de cancers et de maladies auto-immunes. Ainsi, la modulation de ces enzymes permettrait de lutter contre les pathologies associées au système immunitaire. P. aeruginosa est une bactérie Gram negative dotée d’une virulence et d’une résistance aux antimicrobiens remarquable. Aujourd’hui, la résistance aux antibiotiques représente un enjeu de santé publique majeur et il y a un besoin urgent en nouvelles thérapeutiques. Afin de satisfaire ce besoin, de nouvelles stratégies sont apparues comme celle consistant à cibler la virulence des bactéries afin de « désarmer » celles-ci. LasB représente une cible thérapeutique de choix de par sa localisation extracellulaire et ses implications physiopathologiques (colonisation, invasion, évasion à la réponse immunitaire, formation de biofilm, etc.). Bien qu'il y ait un besoin médical évident non satisfait dans ces deux aires thérapeutiques, aucun modulateur des ERAPs ni de LasB n'a atteint le marché. Ainsi, l’utilisation de la stratégie KTGS suivie de phases d’optimisation nous ont permis d’identifier et optimiser de nouvelles familles de ligands de ces enzymes. Ces composés peuvent être considérés comme des leads prometteurs puisqu’ils présentent des affinités nanomolaires pour leurs cibles respectives, des profils de sélectivité et de toxicité ainsi que des propriétés physicochimiques remarquables
Target-guided synthesis of protein ligands is an innovative strategy to discover bioactive compounds. In particular, the Kinetic Target-Guided Synthesis (KTGS) and the Dynamic Combinatorial Chemistry (DCC) have allowed, in recent years, the discovery of novel ligands for poorly explored therapeutic targets, which has enabled drug-discovery projects. This thesis project aims at using KTGS to discover and optimize ligands for two classes of metalloenzymes, namely endoplasmic reticulum aminopeptidases (ERAPs) and elastase LasB from the bacterium Pseudomonas aeruginosa. ERAPs (1 and 2) are involved in the process of antigen maturation. These enzymes cleave peptide precursors into mature antigenic peptides so that they have an optimal size for their complexation to the major histocompatibility complex of class I and thus initiate or not the adaptive immune response. The expression levels of these proteases as well as single nucleotide polymorphisms have been associated with the development of cancers and autoimmune diseases. Thus, the modulation of these enzymes would allow to fight against pathologies associated with the immune system. P. aeruginosa is a Gram-negative bacterium with remarkable virulence and antimicrobial resistance. Today, antibiotic resistance represents a major public health issue and there is an urgent need for new therapeutics. In order to meet this need, new strategies have emerged such as targeting the virulence of bacteria to "disarm" them. LasB represents a therapeutic target of choice due to its extracellular localization and its physiopathological implications (colonization, invasion, evasion of immune response, biofilm formation, etc.). Although there is a clear unmet medical need in these two therapeutic areas, no modulator of ERAPs or LasB has reached the market. Thus, the use of the KTGS strategy followed by optimization phases allowed us to identify and optimize new families of ligands for these enzymes. These compounds can be considered as promising lead compounds since they present nanomolar affinities for their respective targets, selectivity and toxicity profiles as well as remarkable physicochemical properties
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Park, Sukjoon. "Comparative analysis of Pseudomonas aeruginosa LasA and LasD /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476405085.

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Márquez, Jessica J. "Human-automation collaboration : decision support for lunar and planetary exploration /." Cambridge, Mass. : Ft. Belvior, VA : Springfield, Va. : Massachusetts Institute of Technology, Department of Aeronautics and Astronautics ; Available to the public through the Defense Technical Information Center ; National Technical Information Service [distributor], 2007. http://web.mit.edu/aeroastro/labs/halab/index.shtml.

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Thesis (Ph. D in Philosophy (Human-Systems Engineering))--Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, February 2007.
"February 2007." Thesis advisor: Mary L. Cummings. Performed by Massachusetts Institute of Technology, Humans & Automation Laboratory, Cambridge, Mass. "Submitted to the Department of Aeronautics and Astronautics on February 1, 2007 in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Human-Systems Engineering."--P. 3. Includes bibliographical references (p. 219-225). Also available online from the Massachusetts Institute of Technology (MIT) Humans and Automation Lab (HAL) Web site.
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Lash, Catherine Eileen. "Depositional environment and taphonomy of marine vertebrate biofacies in the lower Cretaceous (Albian) thermopolis shale, South-Central Montana." Thesis, Montana State University, 2011. http://etd.lib.montana.edu/etd/2011/lash/LashC1211.pdf.

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In south-central Montana, west of the Pryor Mountain Range, the Lower Cretaceous Thermopolis Formation contains an unusual abundance of marine vertebrate fossils which comprises the majority of the coarse-grained material in an otherwise fine-grained, marine deposit. The fossil zone lacks invertebrates and contains predominantly marine vertebrate skeletal, tooth, and coprolitic material, including; plesiosaur, marine crocodile, shark, freshwater turtle, ray, saw fish, and boney fish. Four lithofacies associations (depositional packages) represent fluctuations of relative sea level within the Western Interior Cretaceous Seaway during Albian time and correspond to the four designated members of the Thermopolis Formation ('rusty beds", Lower Thermopolis, Sandy, and Upper Thermopolis Members). Deposition of the Thermopolis Formation in south-central Montana occurred within a persistent marine basin even during the lowstand event. Two distinct marine vertebrate bioclastic assemblages occur near the middle of the Thermopolis Formation, at the base of the Upper Thermopolis Member, within a 5.6 m thick zone deposited above a the lowstand event. The first fossil assemblage consists of relatively large, isolated and articulated skeletal elements that are generally dispersed throughout the fossil zone within a structureless claystone/mudstone matrix. This assemblage records a low energy, offshore environment (condensed section) with skeletal accumulation primarily driven by suspension settling of biological components and represents an autochthonous to parautochthonous assemblage. The second fossil assemblage consists of relatively small, fragmented bioclasts that are highly concentrated within very thin, cross-laminated litharenite and sandy volcaniclastic ash lenses. These lenses represent high energy event bed deposition resulting from storm-induced flows that entrained and transported previously accumulated fossil material from a nearshore to an offshore environment and represent an allochthonous assemblage. The coarse-grained bioclasts of the second assemblage are transported and therefore do not represent a correlative transgressive lag as previously thought. The second fossil assemblage occurs within the base of the marine vertebrate fossil zone and is surrounded by the first fossil assemblage; both fossil assemblages are time-averaged and occur within a condensed section. Therefore, syndeposition of these two fossil assemblages occurred within the same offshore depositional environment and represent only a change in depositional energy, not a change in overall depositional setting.
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Lamb, Patricia Darlene. "Application of the modeling role-modeling theory to mentoring in nursing." Thesis, Montana State University, 2005. http://etd.lib.montana.edu/etd/2005/lamb/LambP0805.pdf.

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Lamb, Robert Ray. "An information retrieval system for images from the trace satellite." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/lamb/LambR0508.pdf.

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The ability to identify particular features and structures, such as faces or types of scenery in images, is a topic with many available applications and potential solutions. In this paper we discuss solar images and the results of our preliminary investigation of techniques that can be used to identify solar phenomena in images from the TRACE satellite. Being able to automatically identify various phenomena in solar images is of great interest for scientists studying phenomena on the sun. A set of characteristics that can be quickly extracted from solar images needs to be acquired. These characteristics are used to create classifiers for various phenomena contained in solar images. There are many obstacles that need to be overcome when extracting features and creating these classifiers. These include the inherent unbalanced data sets due to varying rates at which different phenomena appear and multiple phenomenon that could appear in each image. The classifiers that have been generated were used in the creation of an information retrieval system to make finding phenomenon solar images quick and easy.
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Jolibois, Michel. "The last essays of Elia de Charles Lamb : traduction, introduction critique et notes." Thesis, Paris 3, 2012. http://www.theses.fr/2012PA030006.

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La présente étude se propose de donner une traduction abondamment annotée de la seconde série des essais d’Élia qui paraissent dans les revues périodiques anglaises, entre 1820 et 1833. Dans un souci d’exactitude, cette traduction restitue les passages supprimés par l’auteur avant leur parution sous forme de recueil. Une attention toute particulière a été portée sur les traductions en français de certains essais d’Élia publiés séparément dans les revues du milieu du dix-neuvième siècle et sur les traductions plus modernes des Essais d’Elia, réunis en recueil, jusqu’à l’époque présente. Les Last Essays of Elia sont la dernière œuvre publiée par Lamb. La tentation était grande de chercher une continuité depuis les premiers écrits jusqu’aux LEE. Dans l’introduction critique, nous nous sommes efforcé de voir les différents aspects de l’oeuvre de Lamb qui est à la fois poète, journaliste, dramaturge, critique de théâtre et épistolier et qui connaît la notoriété dans le genre de l’essai, genre auquel il donne un souffle nouveau, grâce à la persona d’Élia. Le fait que Lamb ait été l’ami des premiers poètes romantiques anglais de l’époque, le fait que sa vie ait été marquée et bouleversée par le meurtre de sa propre mère de la main de sa sœur bien-aimée, confèrent à son œuvre un vif intérêt. Personnalité inclassable du Romantisme anglais, dont il est une figure mineure, humoriste amoureux des livres et de la langue du passé, Lamb n’en reste pas moins un chaînon indispensable pour comprendre la scène littéraire anglaise du début du XIXe siècle
The present study aims to provide a carefully annotated translation of the second series of the Essays of Elia which appeared in English periodical magazines between 1820 and 1833. In order to be as complete as possible, this translation includes the passages removed by the author when they were published in book form in 1833. Particular attention has been paid to French translations of individual Elia essays scattered in mid-nineteenth century French magazines as well as to more modern translations of the collected Essays, up to the present day. The Last Essays of Elia was Lamb’s final published work. It was very tempting to look for threads running through his work from the early writings to the LEE. In the critical introduction, we have sought to consider the various aspects of the work of Lamb, who was at the same time a poet, a journalist, a playwright, a theatre critic and a letter-writer before making his name as an essay-writer, breathing new life into the genre, thanks to the Elia persona. The fact that Lamb was a friend of the first English Romantic poets and that his life was blighted by his mother’s murder at the hands of his beloved sister, brings a vivid interest to his work. An isolated figure of Romanticism, a "very reasonable Romantic" himself, a humourist in love with the books and language of the past, Lamb, though a relatively minor author, remains a key link to understanding the early nineteenth-century English literary scene
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Aly, Safwan Krishnamurti Ramesh. "A framework for interaction and task decomposition for objects emulating agency behavior /." Pittsburgh, Pa. : Carnegie Mellon University, 2000. http://code.arc.cmu.edu/lab/upload/aly%5Fphd%5Fthesis.0.pdf.

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Books on the topic "Lasb"

1

Lasi Weijiasi: Las Vegas. Taibei Shi: Tai ya chu ban you xian gong si, 2006.

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The last lamb: A journey home. [S.l.]: C.W.P., 1998.

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Robert, Graves. Las aventuras del Sargento Lamb. Barcelona: EDHASA, 1985.

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Hayes, Roy. The last days of Las Vegas. Henderson, NV: Solothurnli, 2009.

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Reichholf, Josef. Las: Ekologia laso w s rodkowoeuropejskich. Warszawa: S wiat Ksia ·z ki, 1999.

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Lamb at the altar: The story of a dance. Durham, [N.C.]: Duke University Press, 1994.

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Paul, Wells. Entre ciel et terre: Les sept dernières paroles du Christ. St.-Legier: Contrastes, 1990.

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Friedman, Gary William. The Last Supper: A musical enactment. New York: Samuel French, 1999.

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Friedman, Gary William. The Last Supper: A musical enactment. New York: Samuel French, 1999.

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(Galina), Ivanova G., ed. Ochenʹ bolʹshoe i rokovoe: Posledniĭ god zhizni Sergei︠a︡ Esenina, 1925 / V.A. Vdovin ; [red. G. Ivanova]. Ri︠a︡zanʹ: Izdatelʹ Sitnikov, 2010., 2010.

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Book chapters on the topic "Lasb"

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Bannasch, Stephen, and Boris Berenfeld. "Global Lab: From Classroom Labs to Real-World Research Labs." In Microcomputer–Based Labs: Educational Research and Standards, 247–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61189-6_14.

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Kurata, Takeshi, Ryosuke Ichikari, Ching-Tzun Chang, Masakatsu Kourogi, Masaki Onishi, and Takashi Okuma. "Lab-Forming Fields and Field-Forming Labs." In Serviceology for Services, 144–49. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-61240-9_14.

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Leung, Alexander K. C., William Lane M. Robson, Carsten Büning, Johann Ockenga, Janine Büttner, Hartmut Schmidt, Antonio V. Delgado-Escueta, et al. "LAMB." In Encyclopedia of Molecular Mechanisms of Disease, 1137. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7412.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, I. Savysyuk, and R. Zaremba. "La2Sb." In Structure Types. Part 10: Space Groups (140) I4/mcm – (136) P42/mnm, 211–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19662-1_155.

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Maurer, Martina. "Labs." In Der Mehrwert von Labs als Ansatz in Führungs- und Systementwicklung, 11–37. Wiesbaden: Springer Fachmedien Wiesbaden, 2020. http://dx.doi.org/10.1007/978-3-658-30004-3_2.

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Gooch, Jan W. "Lase." In Encyclopedic Dictionary of Polymers, 419. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_6784.

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Gueye, Youssouph, and Maïssa Mbaye. "eFarm-Lab: Edge AI-IoT Framework for Agronomic Labs Experiments." In Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 101–12. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-90556-9_9.

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Vanderbeke, Dirk. "A last million last moments." In Dasselbe noch einmal: Die Ästhetik der Wiederholung, 196–214. Wiesbaden: VS Verlag für Sozialwissenschaften, 1998. http://dx.doi.org/10.1007/978-3-322-93549-6_11.

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Green, Jennifer, and Michael Green. "Last offices." In Dealing with Death, 114–23. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-7216-3_13.

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MacWhinney, Brian. "Last words." In Trends in Bilingual Acquisition, 257–64. Amsterdam: John Benjamins Publishing Company, 2001. http://dx.doi.org/10.1075/tilar.1.12mac.

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Conference papers on the topic "Lasb"

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Kheir, Saadé, Bérengère Villeret, Nicolas Serafini, Romé Voulhoux, Ignacio Garcia Verdugo, James Di Santo, and Jean-Michel Sallenave. "Pseudomonas aeruginosa LasB subverts innate immunity in alveolar macrophages and epithelial cells." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4984.

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Stickel, Oliver, Melanie Stilz, Anke Brocker, Jan Borchers, and Volkmar Pipek. "Fab:UNIverse - Makerspaces, Fab Labs and Lab Managers in Academia." In the FabLearn Europe 2019 conference. New York, New York, USA: ACM Press, 2019. http://dx.doi.org/10.1145/3335055.3335074.

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Swain, Shovan, Lalit Mohan S., Venkatesh Choppella, and Y. R. Reddy. "Model Driven Approach for Virtual Lab Authoring - Chemical Sciences Labs." In 2018 IEEE 18th International Conference on Advanced Learning Technologies (ICALT). IEEE, 2018. http://dx.doi.org/10.1109/icalt.2018.00062.

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Titov, Igor, Alexander Glotov, Yelizarov Andrey, and Victor Petrov. "Labicom labs: Remote and virtual solid-state laser lab, RF&microwave amplifier remote and virtual lab: Interactive demonstration of Labicom labs in winter 2016." In 2016 13th International Conference on Remote Engineering and Virtual Instrumentation (REV). IEEE, 2016. http://dx.doi.org/10.1109/rev.2016.7444496.

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Correia, Raul Cordeiro, Jose Manuel Fonseca, and Andrew Donnellan. "Ontology: A support structure for a v-labs network, the euronet - lab." In 2012 9th International Conference on Remote Engineering and Virtual Instrumentation (REV). IEEE, 2012. http://dx.doi.org/10.1109/rev.2012.6293141.

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Wilson, John H. "Recipe to lab management or the cookie cutter approach to building labs." In the 30th annual ACM SIGUCCS conference. New York, New York, USA: ACM Press, 2002. http://dx.doi.org/10.1145/588646.588728.

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Pennekamp, Jan, Markus Dahlmanns, Lars Gleim, Stefan Decker, and Klaus Wehrle. "Security Considerations for Collaborations in an Industrial IoT-based Lab of Labs." In 2019 IEEE Global Conference on Internet of Things (GCIoT). IEEE, 2019. http://dx.doi.org/10.1109/gciot47977.2019.9058413.

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Freeman, Joshua, Akshay Nagarajan, Mithula Parangan, Dhanush Kumar, Shyam Diwakar, and Krishnashree Achuthan. "Remote triggered photovoltaic solar cell lab: Effective implementation strategies for Virtual Labs." In 2012 International Conference on Technology Enhanced Education (ICTEE). IEEE, 2012. http://dx.doi.org/10.1109/ictee.2012.6208653.

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Kruse, Daniel, Sulamith Frerich, Markus Petermann, Tobias R. Ortelt, and A. Erman Tekkaya. "Remote labs in ELLI: Lab experience for every student with two different approaches." In 2016 IEEE Global Engineering Education Conference (EDUCON). IEEE, 2016. http://dx.doi.org/10.1109/educon.2016.7474595.

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Danesi Ruiz, Juliana, and Phillip E. Deierling. "Introducing Mechanical Engineering Students to Online Robotics Laboratories." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-68276.

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Abstract Due to Covid-19, in-person robotics labs held in previous semesters were not possible. This paper explores a well-established method to give the students an exceptional learning experience in a robotics class. By surveying students, data was gathered to account for students’ perception when designing the laboratories and lab manuals. In addition, to find an adequate program for the labs, different software was researched and tested. The main factors used to select a software were intuitiveness, cost, online resources, operating system compatibility, Python programming, and software usage. It is concluded that the RoboDK software is the most suitable software for the laboratories, and updated manuals needed to be designed for the Spring 2021 class. Last semester, Spring 2021, another survey was conducted to get students’ feedback on the new lab system. With the additional data, further research may be conducted to refine the laboratories’ assignments and manuals. This paper’s main contribution is to use and analyze RoboDK for online robotics laboratories. Therefore, through this research, a new method was presented that gave students hands-on experience on online laboratories.
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Reports on the topic "Lasb"

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de Luca, Marc, Steve Muller, Barbara Holtz, Nieves Cortes, Bruno Gielis, Michael Justesen, Graeme Carter, et al. The benefits of progressively more sophisticated lab instrument integration instrument intregration in the quality control labs. BioPhorum, March 2022. http://dx.doi.org/10.46220/2022it002.

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Aston, D. The LASS Spectrometer. Office of Scientific and Technical Information (OSTI), June 2018. http://dx.doi.org/10.2172/1454017.

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Marra, James. MacroscoMacroscopic Cracking Determination in LaBS Glasspic Cracking Determination in LaBS Glass. Office of Scientific and Technical Information (OSTI), August 2005. http://dx.doi.org/10.2172/881503.

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Grossman, Richard, and Hugh Rockoff. Fighting the Last War: Economists on the Lender of Last Resort. Cambridge, MA: National Bureau of Economic Research, January 2015. http://dx.doi.org/10.3386/w20832.

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Bruce, Judith. Las niñas rezagadas: dirigir las intervenciones de VIH hacia las más vulnerables. Population Council, 2007. http://dx.doi.org/10.31899/pgy12.1085.

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McGuire, Austin D., and Roger Allen Meade. The Last Big Bang. Office of Scientific and Technical Information (OSTI), September 2016. http://dx.doi.org/10.2172/1324547.

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Jones, Kenneth, and Jr. The Last Black Regulars. Fort Belvoir, VA: Defense Technical Information Center, April 2000. http://dx.doi.org/10.21236/ada378248.

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Cordero Arroyo, G., NL Carrillo Chávez, M. López-Ornelas, and AG Zepeda Fuentes. Análisis de las características de las revistas editadas por las Escuelas Normales mexicanas. Revista Latina de Comunicación Social, January 2019. http://dx.doi.org/10.4185/rlcs-2019-1333.

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Hazi, A. Looping through the Lamb Shift. Office of Scientific and Technical Information (OSTI), February 2007. http://dx.doi.org/10.2172/902624.

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Lee, Sandra L. National Labs Update for Librarians. Office of Scientific and Technical Information (OSTI), June 2017. http://dx.doi.org/10.2172/1460397.

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