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Bastaert, Fabien. "La sécrétion de LasB par Pseudomonas aeruginosa, un mécanisme de défense efficace pour échapper aux macrophages alvéolaires de l'hôte." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC055.
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Pseudomonas aeruginosa (P. A) est, à cause de sa virulence, un des agents pathogènes les plus connus notamment dans les cas d'infections nosocomiales et dans la mucoviscidose où la morbidité et la mortalité des patients sont engagées. Si la capacité d'antibiorésistance de P. A explique cette réalité, il ne faut cependant pas ignorer la diversité des toxines qu'elle produit. Parmi celles qui font sa force, la pertinence des facteurs de virulence sécrétés et injectés par le système de sécrétion du type III (SSTIII) est plus qu'avérée, a contrario de ceux sécrétés par le SSTII. Il existe bien une vaste littérature sur le rôle de LasB in vitro, mais rare sont les études mentionnant son action directe sur les cellules myéloïdes. Pour les enrichir, nous avons justement inscrit ce manuscrit dans cette rareté et finalement, en plus de démontrer que LasB est bien la toxine majeure sécrétée par le SSTII, nous montrons pour la première fois qu'elle est capable d'agir de manière directe sur les macrophages alvéolaires (MA). En effet, au travers de nos travaux, LasB s'est révélée être une toxine ciblant et inhibant l'activité bactériolytique des MA in vivo, ex vivo et in vitro et ce, dans des conditions non-opsoniques comme peuvent l'être celles des alvéoles naïves et saines. Toutefois, même si les technologies utilisées ont été nombreuses, le mécanisme sous-jacent à cette action directe de LasB sur les MA reste une énigme. Malgré cela, notre étude apporte de nouveaux éléments permettant de comprendre pourquoi chez des individus immunologiquement sensibles P. A, en échappant à la réponse de l'hôte, s'implante précocement puis irrémédiablement dans leur poumonBecause of its virulence Pseudomonas aeruginosa (P. A) is one of the main pathogens causing numerous cases of nosocomial infections. It is also present in the airways of cystic fibrosis patients in which it is associated with an increased morbidity and mortality. Although this can partly be explained by its antibiotic resistance, the diversity of toxins it produces should not be ignored. Among those, the relevance of virulence factors secreted and injected through the type III secretion system (TIIISS) is undeniable, however those secreted by the TIISS are underestimated. There is indeed a vast literature on the role of the elastase LasB in vitro, but studies indicating its direct action on myeloid cells are rare. To enrich them, we have registered our manuscript in this rarity and finally, in addition to demonstrating that LasB is the major toxin secreted by the TIISS, we show for die first time that LasB is able to act directly on alveolar macrophages (AM). Indeed, throughout our work, LasB bas proved to be a toxin targeting and inhibiting the bacteriolytic activity of AM in vivo, ex vivo and in vitro and in non-opsonic conditions as can those of naive and healthy alveoli. Although different pathways using numerous techniques have been investigated, the underlying mechanism for this direct action of LasB on AM remains unclear. Nevertheless, our study provides new evidence that contributes to understand why in immunologically susceptible individuals, P. A is setting up early and irrevocably in their lung at least partly by escaping the host's immune response
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Walter, Isabell [Verfasser]. "Anti-infectives for novel targets : development of inhibitors targeting CYP121 from mycobacterium tuberculosis and LasB from pseudomonas aeruginosa / Isabell Walter." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1236897056/34.
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Camberlein, Virgyl. "Target-guided synthesis of metalloenzymes ligands with therapeutic applications." Thesis, Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS004.
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La synthèse guidée par la cible de ligands protéiques est une stratégie innovante pour découvrir des composés bioactifs. En particulier, la Kinetic Target-Guided Synthesis (KTGS) and the Dynamic Combinatorial Chemistry (DCC) ont permis, ces dernières années, de découvrir des ligands originaux pour des cibles thérapeutiques mal explorées, ce qui a permis de lancer des projets de découverte de médicaments. Ce projet de thèse vise à utiliser la KTGS pour découvrir, puis optimiser des ligands de deux classes de métalloenzymes que sont les aminopeptidases du réticulum endoplasmiques (ERAP) et l’élastase LasB de la bactérie Pseudomonas aeruginosa. Les ERAPs (1 et 2) participent au processus de maturation des antigènes. Ces enzymes clivent les précurseurs peptidiques en peptides antigéniques matures afin que ceux-ci disposent d’une taille optimale pour leur complexation au complexe majeur d’histocompatibilité de classe I et ainsi initient ou non la réponse immunitaire adaptative. Les niveaux d’expression de ces protéases ainsi que des polymorphismes d’un seul nucléotide ont été associé au développement de cancers et de maladies auto-immunes. Ainsi, la modulation de ces enzymes permettrait de lutter contre les pathologies associées au système immunitaire. P. aeruginosa est une bactérie Gram negative dotée d’une virulence et d’une résistance aux antimicrobiens remarquable. Aujourd’hui, la résistance aux antibiotiques représente un enjeu de santé publique majeur et il y a un besoin urgent en nouvelles thérapeutiques. Afin de satisfaire ce besoin, de nouvelles stratégies sont apparues comme celle consistant à cibler la virulence des bactéries afin de « désarmer » celles-ci. LasB représente une cible thérapeutique de choix de par sa localisation extracellulaire et ses implications physiopathologiques (colonisation, invasion, évasion à la réponse immunitaire, formation de biofilm, etc.). Bien qu'il y ait un besoin médical évident non satisfait dans ces deux aires thérapeutiques, aucun modulateur des ERAPs ni de LasB n'a atteint le marché. Ainsi, l’utilisation de la stratégie KTGS suivie de phases d’optimisation nous ont permis d’identifier et optimiser de nouvelles familles de ligands de ces enzymes. Ces composés peuvent être considérés comme des leads prometteurs puisqu’ils présentent des affinités nanomolaires pour leurs cibles respectives, des profils de sélectivité et de toxicité ainsi que des propriétés physicochimiques remarquablesTarget-guided synthesis of protein ligands is an innovative strategy to discover bioactive compounds. In particular, the Kinetic Target-Guided Synthesis (KTGS) and the Dynamic Combinatorial Chemistry (DCC) have allowed, in recent years, the discovery of novel ligands for poorly explored therapeutic targets, which has enabled drug-discovery projects. This thesis project aims at using KTGS to discover and optimize ligands for two classes of metalloenzymes, namely endoplasmic reticulum aminopeptidases (ERAPs) and elastase LasB from the bacterium Pseudomonas aeruginosa. ERAPs (1 and 2) are involved in the process of antigen maturation. These enzymes cleave peptide precursors into mature antigenic peptides so that they have an optimal size for their complexation to the major histocompatibility complex of class I and thus initiate or not the adaptive immune response. The expression levels of these proteases as well as single nucleotide polymorphisms have been associated with the development of cancers and autoimmune diseases. Thus, the modulation of these enzymes would allow to fight against pathologies associated with the immune system. P. aeruginosa is a Gram-negative bacterium with remarkable virulence and antimicrobial resistance. Today, antibiotic resistance represents a major public health issue and there is an urgent need for new therapeutics. In order to meet this need, new strategies have emerged such as targeting the virulence of bacteria to "disarm" them. LasB represents a therapeutic target of choice due to its extracellular localization and its physiopathological implications (colonization, invasion, evasion of immune response, biofilm formation, etc.). Although there is a clear unmet medical need in these two therapeutic areas, no modulator of ERAPs or LasB has reached the market. Thus, the use of the KTGS strategy followed by optimization phases allowed us to identify and optimize new families of ligands for these enzymes. These compounds can be considered as promising lead compounds since they present nanomolar affinities for their respective targets, selectivity and toxicity profiles as well as remarkable physicochemical properties
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Park, Sukjoon. "Comparative analysis of Pseudomonas aeruginosa LasA and LasD /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487942476405085.
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Márquez, Jessica J. "Human-automation collaboration : decision support for lunar and planetary exploration /." Cambridge, Mass. : Ft. Belvior, VA : Springfield, Va. : Massachusetts Institute of Technology, Department of Aeronautics and Astronautics ; Available to the public through the Defense Technical Information Center ; National Technical Information Service [distributor], 2007. http://web.mit.edu/aeroastro/labs/halab/index.shtml.
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Thesis (Ph. D in Philosophy (Human-Systems Engineering))--Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, February 2007."February 2007." Thesis advisor: Mary L. Cummings. Performed by Massachusetts Institute of Technology, Humans & Automation Laboratory, Cambridge, Mass. "Submitted to the Department of Aeronautics and Astronautics on February 1, 2007 in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Human-Systems Engineering."--P. 3. Includes bibliographical references (p. 219-225). Also available online from the Massachusetts Institute of Technology (MIT) Humans and Automation Lab (HAL) Web site.
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Lash, Catherine Eileen. "Depositional environment and taphonomy of marine vertebrate biofacies in the lower Cretaceous (Albian) thermopolis shale, South-Central Montana." Thesis, Montana State University, 2011. http://etd.lib.montana.edu/etd/2011/lash/LashC1211.pdf.
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In south-central Montana, west of the Pryor Mountain Range, the Lower Cretaceous Thermopolis Formation contains an unusual abundance of marine vertebrate fossils which comprises the majority of the coarse-grained material in an otherwise fine-grained, marine deposit. The fossil zone lacks invertebrates and contains predominantly marine vertebrate skeletal, tooth, and coprolitic material, including; plesiosaur, marine crocodile, shark, freshwater turtle, ray, saw fish, and boney fish. Four lithofacies associations (depositional packages) represent fluctuations of relative sea level within the Western Interior Cretaceous Seaway during Albian time and correspond to the four designated members of the Thermopolis Formation ('rusty beds", Lower Thermopolis, Sandy, and Upper Thermopolis Members). Deposition of the Thermopolis Formation in south-central Montana occurred within a persistent marine basin even during the lowstand event. Two distinct marine vertebrate bioclastic assemblages occur near the middle of the Thermopolis Formation, at the base of the Upper Thermopolis Member, within a 5.6 m thick zone deposited above a the lowstand event. The first fossil assemblage consists of relatively large, isolated and articulated skeletal elements that are generally dispersed throughout the fossil zone within a structureless claystone/mudstone matrix. This assemblage records a low energy, offshore environment (condensed section) with skeletal accumulation primarily driven by suspension settling of biological components and represents an autochthonous to parautochthonous assemblage. The second fossil assemblage consists of relatively small, fragmented bioclasts that are highly concentrated within very thin, cross-laminated litharenite and sandy volcaniclastic ash lenses. These lenses represent high energy event bed deposition resulting from storm-induced flows that entrained and transported previously accumulated fossil material from a nearshore to an offshore environment and represent an allochthonous assemblage. The coarse-grained bioclasts of the second assemblage are transported and therefore do not represent a correlative transgressive lag as previously thought. The second fossil assemblage occurs within the base of the marine vertebrate fossil zone and is surrounded by the first fossil assemblage; both fossil assemblages are time-averaged and occur within a condensed section. Therefore, syndeposition of these two fossil assemblages occurred within the same offshore depositional environment and represent only a change in depositional energy, not a change in overall depositional setting.
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Lamb, Patricia Darlene. "Application of the modeling role-modeling theory to mentoring in nursing." Thesis, Montana State University, 2005. http://etd.lib.montana.edu/etd/2005/lamb/LambP0805.pdf.
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Lamb, Robert Ray. "An information retrieval system for images from the trace satellite." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/lamb/LambR0508.pdf.
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The ability to identify particular features and structures, such as faces or types of scenery in images, is a topic with many available applications and potential solutions. In this paper we discuss solar images and the results of our preliminary investigation of techniques that can be used to identify solar phenomena in images from the TRACE satellite. Being able to automatically identify various phenomena in solar images is of great interest for scientists studying phenomena on the sun. A set of characteristics that can be quickly extracted from solar images needs to be acquired. These characteristics are used to create classifiers for various phenomena contained in solar images. There are many obstacles that need to be overcome when extracting features and creating these classifiers. These include the inherent unbalanced data sets due to varying rates at which different phenomena appear and multiple phenomenon that could appear in each image. The classifiers that have been generated were used in the creation of an information retrieval system to make finding phenomenon solar images quick and easy.
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Jolibois, Michel. "The last essays of Elia de Charles Lamb : traduction, introduction critique et notes." Thesis, Paris 3, 2012. http://www.theses.fr/2012PA030006.
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La présente étude se propose de donner une traduction abondamment annotée de la seconde série des essais d’Élia qui paraissent dans les revues périodiques anglaises, entre 1820 et 1833. Dans un souci d’exactitude, cette traduction restitue les passages supprimés par l’auteur avant leur parution sous forme de recueil. Une attention toute particulière a été portée sur les traductions en français de certains essais d’Élia publiés séparément dans les revues du milieu du dix-neuvième siècle et sur les traductions plus modernes des Essais d’Elia, réunis en recueil, jusqu’à l’époque présente. Les Last Essays of Elia sont la dernière œuvre publiée par Lamb. La tentation était grande de chercher une continuité depuis les premiers écrits jusqu’aux LEE. Dans l’introduction critique, nous nous sommes efforcé de voir les différents aspects de l’oeuvre de Lamb qui est à la fois poète, journaliste, dramaturge, critique de théâtre et épistolier et qui connaît la notoriété dans le genre de l’essai, genre auquel il donne un souffle nouveau, grâce à la persona d’Élia. Le fait que Lamb ait été l’ami des premiers poètes romantiques anglais de l’époque, le fait que sa vie ait été marquée et bouleversée par le meurtre de sa propre mère de la main de sa sœur bien-aimée, confèrent à son œuvre un vif intérêt. Personnalité inclassable du Romantisme anglais, dont il est une figure mineure, humoriste amoureux des livres et de la langue du passé, Lamb n’en reste pas moins un chaînon indispensable pour comprendre la scène littéraire anglaise du début du XIXe siècleThe present study aims to provide a carefully annotated translation of the second series of the Essays of Elia which appeared in English periodical magazines between 1820 and 1833. In order to be as complete as possible, this translation includes the passages removed by the author when they were published in book form in 1833. Particular attention has been paid to French translations of individual Elia essays scattered in mid-nineteenth century French magazines as well as to more modern translations of the collected Essays, up to the present day. The Last Essays of Elia was Lamb’s final published work. It was very tempting to look for threads running through his work from the early writings to the LEE. In the critical introduction, we have sought to consider the various aspects of the work of Lamb, who was at the same time a poet, a journalist, a playwright, a theatre critic and a letter-writer before making his name as an essay-writer, breathing new life into the genre, thanks to the Elia persona. The fact that Lamb was a friend of the first English Romantic poets and that his life was blighted by his mother’s murder at the hands of his beloved sister, brings a vivid interest to his work. An isolated figure of Romanticism, a "very reasonable Romantic" himself, a humourist in love with the books and language of the past, Lamb, though a relatively minor author, remains a key link to understanding the early nineteenth-century English literary scene
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Aly, Safwan Krishnamurti Ramesh. "A framework for interaction and task decomposition for objects emulating agency behavior /." Pittsburgh, Pa. : Carnegie Mellon University, 2000. http://code.arc.cmu.edu/lab/upload/aly%5Fphd%5Fthesis.0.pdf.
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Turnbull, Elwin Donald, of Western Sydney Hawkesbury University, and Faculty of Agriculture and Rural Development. "Developing the Australian lamb industry using action research." THESIS_FARD_XXX_Turnball_E.xml, 1993. http://handle.uws.edu.au:8081/1959.7/84.
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This document reports on the rationale for and results of using action research in order to facilitate development of the Australian lamb industry. The contexts of this research were: a lamb industry that had declining consumption; producers were slow to change to the production of new style of lamb which more closely aligned with consumer trends towards lower fat and convenience foods; and major changes in research funding criteria, towards projects with measurable impacts upon industries. The perspective taken in this research was that the production and marketing of lamb is essentially a human activity. Action research was effective in providing a methodology for working with extension and research officers using focus group meetings with lamb producers in South Eastern Australia. The key activity was the creation of an environment for a rich social discourse between industry people, focussing on establishing suitable processes and relationships within the industry. Valuable resources consisting of current industry skills, knowledge and institutions were utilised through this project for the benefit of the industry. This project illustrated a role for action research as an effective way of facilitating learning and communication in the lamb industry. The impact of the project was limited because the activities were confined to the production end of the marketing channel. The research helped the author to develop a deeper understanding of participatory action research and the close linkage between learning and self image. The experience of conducting the research validated the importance of the group dynamic in action research and the difficulty that individuals and groups have in matching actions with espoused theoryMaster of Science (Hons)
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Christofor-Ganev, Yvonne. "Charles und Mary Lambs "Tales from Shakespeare" /." Frankfurt am Main : P. Lang, 1995. http://catalogue.bnf.fr/ark:/12148/cb37702970p.
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Garza, Horacio III. "The Effects of Age, Sex, and Hot Carcass Weight on Cooked Lamb Flavor and Off Flavor in Four Muscle Cuts." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1511949373145599.
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Díaz, Valdivia José María, and Fernández-Dávila Hernán Víctor Valencia. "Propuesta de implementación del aplicativo Trello para la gestión de las restricciones en Last Planner® System." Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623852.
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Last Planner es una herramienta muy potente de Lean Construction, pero su utilización no garantiza lograr los objetivos de plazo de un proyecto. Esta investigación se centra en una de las causas por las que los plazos se alargan a pesar de usar Last Planner, o creer hacerlo, y la deficiente gestión de restricciones. Para potenciar este paso tan importante, se ha implementado el uso de Tecnología de la Información y Comunicaciones (TIC ‘s), mediante un aplicativo móvil utilizado desde hace más de 4 años en la industria de telecomunicaciones e informática para el trabajo colaborativo.
La metodología aplicada consistió en analizar un proyecto en curso e implementar un Manual para el uso eficiente del aplicativo, además de unos indicadores de gestión capaces de medir el performance del Porcentaje del Plan Cumplido en una propuesta innovadora y moderna con resultados que se comparten en esta investigación.Last Planner is a very powerful tool of Lean Construction, but its use does not guarantee to achieve the project's deadline objectives. This research focuses on one of the reasons why deadlines are lengthened despite using Last Planner, or believing it and it is the deficient management of restrictions. To enhance this important step, the use of information technology and communications (ICT) has been implemented, using a mobile application used for more than 4 years in the telecommunications and informatics industry for collaborative work. The applied methodology consisted in analyzing an ongoing project and implementing a handbook for the efficient use of the application, as well as management indicators able to measure the performance of the Percent Plan Completed in an innovative and modern proposal shared in this research.
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Hecker, Joel W. "QUANTIFYING RECHARGE DURING THE LAST GLACIAL MAXIMUM IN THE DEATH VALLEY REGIONAL FLOW SYSTEM." Miami University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1343158292.
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Johnson, Stacey Ann. "The influence of early postmortem enhancement and inclusion of dextrose on lamb longissimus tenderness." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1236709470.
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Lo, Amadou. "Le développement de l’ambidextrie contextuelle à l’aide d’un outil de gestion : étude de cas exploratoire du Fab Lab interne chez Renault." Thesis, Lyon 3, 2015. http://www.theses.fr/2015LYO30064/document.
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Cette thèse a pour objectif de mieux comprendre et d’accompagner les stratégies d’innovation des entreprises face aux défis liés à l’intensification de la dynamique et des changements de l’environnement économique. Or, afin de survivre à ces rythmes économiques, la littérature préconise aux organisations de concilier leurs activités d’exploitation et leurs activités d’exploration de façon concomitante. Dans ce cadre, notre travail étudie spécifiquement une stratégie d’innovation conférant une importance particulière aux initiatives des individus dans les activités d’exploration : l’ambidextrie contextuelle. Simultanément, notre recherche examine un objet de recherche jusque là inédit dans le milieu académique : le Fab Lab d’entreprise (ou Fab Lab interne). A la croisée des chemins de ces deux sujets, cette thèse pose la question du développement de l’ambidextrie contextuelle à l’aide d’un Fab Lab d’entreprise.L’étude de cas menée au sein de l’une des premières structures à développer cette pratique de Fab Lab d’entreprise – le Groupe Renault – définit cet outil de gestion comme une quasi-structure propice au développement de l’ambidextrie contextuelle. Elle présente ensuite le pilotage à mener afin de développer l’ambidextrie contextuelle à l’aide d’un Fab Lab d’entrepriseThis thesis aims to better understand and support corporate innovation strategies to help them coping with the challenges associated with the intensification of the dynamics and changes in the economic environment. However, in order to survive these economic rhythms, previous research recommends organizations to reconcile their exploitation and their exploration activities, concomitantly. In this context, our work specifically examines an innovation strategy giving particular attention to the initiatives of individuals in exploration activities : contextual ambidexterity. Simultaneously, our research examines an object of research previously unreleased in academic studies : the corporate Fab Lab (or internal Fab Lab). At the crossroads of these two subjects, this thesis raises the question of the development of contextual ambidexterity through a corporate Fab Lab. Our case study is conducted in Renault Group, one of the first structures to develop this practice of corporate Fab Lab. Our analysis permits to define this management tool as a quasi-structure conducive to the development of contextual ambidexterity. It then presents the guidance to lead in the objective of developing contextual ambidexterity through a corporate Fab Lab
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Ferchaud, Flavie. "Fabriques numériques, action publique et territoire : en quête des living labs, fablabs et hackerspaces (France, Belgique)." Thesis, Rennes 2, 2018. http://www.theses.fr/2018REN20010/document.
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Cette thèse part du constat de l’incorporation d’objets appelés « fablab », « hackerspace » ou « living lab » dans les politiques publiques. Le déploiement démultiplié de ces nouveaux « lieux » au coeur ou aux marges de l'action publique des collectivités, s’accompagne d'une sémantique associant l'innovation, l'entrepreneuriat, la flexibilité et la créativité. Cette thèse démontre qu'au-delà de ces effets rhétoriques et de la fascination qu'ils exercent (mais qui s'explique), ces objets de politiques publiques constituent une des réalités de l'action métropolitaine, sous différents registres et modalités. En se distançant des discours laudatifs qui accompagnent leur émergence, la thèse fait de l'analyse de leurs rapports au territoire et de leurs prises avec les dynamiques de l'espace urbain son objet central. La prise en compte de la complexité de l’objet de recherche et de son inscription dans une action publique en constant changement impose de s’intéresser auxlogiques de l’espace propres à la géographie et l’aménagement et de recourir aux apports d’autres disciplines, telles que la sociologie et la science politique. L’enquête articule des espaces, des temps et des méthodes d’enquête différentes. À une première enquête en France portant sur les hackerspaces, les fablabs et les living labs succède une enquête comparative à l'échelle européenne (Rennes et Toulouse en France, Gand en Belgique). La thèse expose et décrypte les promesses portées par ces lieux. Des tensions sont mises en évidence, l'une, majeure, les situant entre héritage de la contre-culture, processus de normalisation et de « récupération ». Ces tensions constituent les fils directeurs de la thèse : elles traversent l’inscription des dispositifs d’expérimentation et de fabrication numérique dans un contexte de mutations spécifiques aux villes contemporaines. La thèse éclaire également, en s'appuyant sur les notions de « monde social », de « communs » et de « communs urbains », leurs dynamiques sociales. Démontant en partie les représentationsenthousiastes dont fablabs, hackerspaces et living labs restent majoritairement l’objet, la thèse relativise leur portée en termes d’intégration et d’ouverture, autant que leur rôle dans la transformation des politiques urbaines localesThe starting point of this doctoral research is the observation of the incorporation of objects called "fablab", "hackerspace" or "living lab" in public policies. The increased expansion of these new "places" at the heart or at the margins of public policies is supported by semantics associated with innovation, entrepreneurship, flexibility and creativity. But beyond these rhetorical effects and their fascination, it is demonstrated that these objects of public policies constitute one of the realities of the metropolitan action, under different modalities. This thesis stays away from the laudatory discourses that accompany the emergence of these objects and mainly focuses on the analysis of their relationships to the territory and the dynamics of the urban space. It has to be taken into account that the complexity of these places and their inclusion in an everevolvingpublic policy requires to use the logics of space, specific to geography and planning, and to resort to other disciplines contributions, such as sociology and political science. The investigation articulates different spaces, time periods, and survey methods. A first investigation in France on hackerspaces, fablabs and living labs was followed by a comparative investigation on a European scale (Rennes and Toulouse in France, Ghent in Belgium). The thesis exposes and interprets the promises driven by these places. Tensions are highlighted. One major tension situates these places between inheritance of the counterculture, process of normalisation and "recovery". These tensions represent the main thread of the thesis: they run through the insertion of places of experimentation and digital manufacturing in a context of changes, inherent to contemporary cities. Based on notions such as "social world", "common" and "urban commons", the thesis also sheds lights on the social dynamics of these places. Partly dismantling the enthusiastic representations regarding fablabs,hackerspaces and living labs, the thesis puts their scope in perspective in terms of integration and openness, as well as their role in the transformation of local urban policies
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Köllermann, Antje-Fee. "Conrad Laib : ein spätgotischer Maler aus Schwaben in Salzburg /." Berlin : Deutscher Verlag für Kunstwissenschaft, 2007. http://catalogue.bnf.fr/ark:/12148/cb41293019z.
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Koabaz, Mahmoud. "Contribution à l’étude des ondes de LAMB dans une plaque anisotrope : théorie et expérience." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14071/document.
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Le rayonnement d'une source ultrasonore située sur l'une des interfaces d'une plaque anisotrope est étudié. Le calcul du tenseur de Green est effectué dans le cas général d'un problème 3D. Une décomposition en multiples réflexions /réfractions, constituant une série de rayons au sein de la plaque, est utilisée pour une comparaison théorie-expérience dans le cas d'un mono cristal de Cuivre. La vitesse de phase et la vitesse d'énergie sont mesurées en fonction de la fréquence ou de la direction d'observation, pour une plaque de carbone-époxy unidirectionnels, et comparées avec la théorieThe ultrasonic radiation from a source located on one of the interfaces of an anisotropic plateis studied. The calculation of the Green tensor is performed in the general case of a 3Dproblem. Decomposition into multiple reflections /refractions, as a series of rays in the plate,is used for comparison between theory and experiment in the case of a single crystal of copper. The phase velocity and energy velocity are measured in terms of frequency ordirection of observation, for a plate of unidirectional carbon-epoxy, and compared withtheory
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Rainisch, Uri. "Detection of Ultrasonic Lamb Waves in Paper Using an Optical MEMS Microphone." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/4779.
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Laser ultrasonics has been used to measure the bending stiffness of paper products by measuring the dispersion of ultrasonic plate waves. In laser ultrasonics, ultrasound can be generated by absorption of pulsed laser spot while detection can be carried out by Laser Doppler Interferometry. The research presented in this paper describes a new method to detect ultrasonic plate waves using a recently developed acoustic transducer, more specifically an optical Micro ElectroMechanical System (MEMS) microphone with broadband capability. The MEMS device operates as a non-contact proximity probe placed less than ¼ a millimeter away from the plate. The signals are detected with a capacitive micromachined ultrasonic transducer (cMUT) in which the back electrode of the capacitive transducer on a transparent substrate is shaped as an optical diffraction grating. The displacement of the transducer membrane is determined using an optical interferometer. By applying voltage to deflect the membrane electrostatically, the detection sensitivity is kept at an optimum level.
The main purpose of the research presented herein was to test this MEMSs ability to detect ultrasonic waves propagating through paper, to increase the signal-to-noise ratio (SNR), and to calibrate the device in order to quantify the limitations on sensitivity in the context of the detection of ultrasound in paper. Similar tests were conducted for comparison with a modified Mach-Zehnder Interferometer, a more traditional method used for laser ultrasonic detection, and its results are presented in this paper.
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Al-Breihi, Mohammed. "Utveckling av laboration om trefastransformatorn : En studie om transformatorer." Thesis, KTH, Skolan för teknik och hälsa (STH), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-166240.
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Examensarbetet har utforts pa uppdrag av enheten for Data- och Elektroteknik pa skolan for Teknik och Halsa, KTH. Denna studie om transformatorer omfattar deras funktioner och anvandningsomraden, hur de ar uppbyggda, hur karnan och lindningarna som ar transformatorns viktigaste delar ar uppbyggda, vilka materiel som anvands vid konstruktion av dessa samt vilka typer det finns av dem beskrivs i rapporten. Vidare beskrivs flera olika transformatortypers funktioner och anvandningsomraden. Eftersom en viktig del av studien varit pa vilka satt transformatorer kan utvecklas for okad miljovanlighet och livslangd gar rapporten igenom olika vegetabiliska oljor, vilka fordelar de har gentemot mineraloljor och vilka egenskaper de har samt pa vilket satt de ar skonsammare mot miljon. HVDC-enheter transformerar hoga spanningar fran vaxelspanning till likspanning for mindre resistiva forluster och darmed lagre energiforluster vilket i sin tur leder till en renare miljo. Teorigenomgangen av transformatorn ligger till grund for utformningen av en laboration for undervisningsbruk, bl.a. i en kurs om elkraftteknik som ges i hogskoleingenjorsprogrammet Elektroteknik pa KTH.This degree project was carried out on behalf of the unit for Computer and Electrical engineering at the School of Technology and Health, KTH. This study about transformers, their function and uses, the way they’re built, how the core and windings, which are the most important parts of a transformer, are made and what kind of materials are used to make them. Several types of transformers and their functions are described. A crucial part of the study has been to search for different ways to develop transformers to make them environmentally safer and to increase their life-span. As such this work describes different transformer oils, what advantages and disadvantages they have compared to mineral oils, what properties they have and in what way they’re less harmful for the environment. HVDC units transform high voltages from Alternating Current to Direct Current to lessen the resistive losses and energy losses which lead to a cleaner environment. The theory examination of the transformer is the basis for the formation of a lab for educational use, among others in a course about electrical power that’s included in Bachelor of Science in Electrical Engineering at KTH.
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Tschirhart, Tara Elizabeth. "Histological, physical, and chemical factors of various lamb muscles." Texas A&M University, 2003. http://hdl.handle.net/1969.1/235.
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Muscles (n = 18) were dissected from each side of twenty lamb carcasses. Muscles from the right sides of the carcasses were used to determine weight, length, width, minimum and maximum thickness, objective color measurements, water-holding capacity (WHC), pH, total collagen content, sarcomere length, and fat and moisture content. Muscles from the left sides of the carcasses were aged for seven days and used to determine percent cook loss, and Warner-Bratzler shear force values. The M. teres major was lightest (P < 0.05) in weight and smallest in surface area, while the M. longissimus lumborum was heaviest (P < 0.05) in weight, and the M. serratus ventralis was largest in surface area. M. adductor and M. semimembranosus were found to be the darkest in color (P < 0.05), while the M. latissimus dorsi and M. tensor fasciae latae were the lightest (P < 0.05). M. triceps brachii had the highest WHC and the M. longissimus lumborum the lowest. The M. teres major and M. serratus ventralis had the highest (P < 0.05) pH values. The M. infraspinatus was found to have the highest collagen content (9.00 mg/g) and the M. psoas major revealed the longest sarcomere lengths (3.06 μm). M. serratus ventralis possessed the highest (P < 0.05) percent fat and the lowest moisture content. M. serratus ventralis had the lowest cook loss (17.1%) and M. supraspinatus had the highest (25.6%). Of the muscles sampled, the M. serratus ventralis was found to have the lowest shear force value (21.8 newtons) and the M. semimembranosus had the highest (42.6 newtons).
Based on the findings of these data, it is likely to conclude that certain muscles may be suitable for individual muscle applications while others may not be suitable or may pose certain palatability problems.
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Krawczel, Peter Downs. "Effect of duration of transport on indicators of stress in lambs." Texas A&M University, 2004. http://hdl.handle.net/1969.1/4882.
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Recommendations for the transportation of lambs from a European Commission,
which required rest stops of 6 or 24 h, every 8 h, were evaluated for efficacy of reducing
stress indicators using Rambouillet x Suffolk lambs (17.6 ñ 0.5 kg). The lambs were
randomly assigned to one of three groups: 1) transported for 22 h (Continuous; n = 15); 2)
transported for 8 h, unloaded and rested for 6 h, transported for 8 h, unloaded and rested for
24 h, transported for 6 h (Rested, n = 15); and 3) Control, which remained in home pasture
throughout the study (n = 16). The rest stops were off-trailer; a different pen was used for
each; and, a limited amount of grain and ad lib hay and water were provided. Mean
temperature in the trailer during the study was 28.4ð C with a range of 18.2ð C to 39.6ð C.
Food deprivation in the Continuous lambs was reflected by a decrease in plasma glucose (P
< 0.001) and an increase in blood urea nitrogen (P < 0.001), creatinine (P < 0.02) and total
bilirubin (P < 0.001) relative to the Rested or the Control lambs. Electrolytes varied within
and between all three treatments (P < 0.05), but no distinct pattern indicating dehydration
was evident. Serum concentrations of cortisol were greater (P < 0.05) in Continuous lambs
than in the Control lambs at 14 h and both the Continuous and Rested lambs had higher
concentrations of cortisol (P < 0.05) compared to the Control lambs at 22 h. Plasma IgG
antibody response to ovalbumin was suppressed (P < 0.05) in the Continuous and Rested lambs compared to the Control lambs. Lambs in both transported treatments ate grain
immediately upon release into the rest pens and drinking occurred following the food
consumption. The Continuous lambs lost a greater (P < 0.05) amount of initial BW at the
conclusion of transport compared to the Rested lambs and had a lower BW (P < 0.05) than
the Rested and Control lambs 8 d after the start of transport. Rest stops improved welfare by
reducing physical stress of food deprivation and eliminating BW loss during transport.
However, rest stops failed to completely alleviate immunosuppression and 52 h were
required to complete the otherwise 22 h long trip. The additional costs of providing the
benefits of the rest stops should be examined before these regulations are widely
implemented.
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au, R. Jacob@central murdoch edu, and Robin Henry Jacob. "Optimising the concentration of glycogen in lamb meat." Murdoch University, 2003. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20040513.153312.
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The lamb industry is actively seeking to improve the quality of lamb meat produced in Australia. Ultimate pH (pHu) is a key determinant of red meat eating quality although this measurement has not been adopted formally by the Australian lamb meat industry. Muscle glycogen concentration is a major determinant of pHu in red meat. This thesis investigates glycogen concentration in lamb muscle and the ultimate pH (pHu) of lamb meat under commercial industry conditions as well as exploring by experimentation, some of the factors that control muscle glycogen concentration in lamb muscle. The results of this work has contributed to an understanding of the significance of high pHu meat to the lamb industry and will assist with developing new management strategies for lambs that avoid low muscle glycogen concentration at the point of slaughter, thus high pHu in meat derived from lambs.
The first part of the study (Experiments 1 and 2) undertook to determine the ranges of muscle glycogen concentration and lamb meat pHu found under commercial conditions and to measure any changes in these parameters associated with consignment of lambs from farm to abattoir and lairage at abattoirs. This study utilised a new biopsy technique that allowed muscle collection from lambs on farm. Some 16 different consignments of lambs and 3 consignments of lactating ewes were intensively monitored on farm and at abattoirs over a range of lairage times. Sensory evaluation tests were done using meat from 6 of these consignments.
The results showed there to be considerable variation between lamb consignments with some consignments having a very high and other consignments having a very low incidence of meat with a high pHu. On balance on farm factors were concluded to have a greater impact on muscle glycogen concentration at slaughter than post farm gate factors. However, there was evidence that muscle glycogen concentrations decreased during the farm curfew and transport period for some consignments so both on farm and post farm gate factors can be important. Characteristically glycogen loss occurred during the farm curfew and transport period in consignments of Merino lambs that had high muscle glycogen concentrations prior to consignment. Holding lambs in lairage caused no negative effects on muscle glycogen concentration although there was some evidence that very short lairage periods may increase meat pHu without causing a change in muscle glycogen concentration. It was concluded from these experiments that the mean muscle glycogen concentration of a group of lambs needs to be greater than 1.5 g/100g on farm in order for the pHu of lamb meat to be less than 5.7.
Subsequent to this industry study, an experiment (Experiment 3) was done to gain an understanding of muscle glycogen concentration as being an integral part of whole body glucose metabolism. This experiment investigated the effects of exercise on a range of different muscles and tissues of lambs including liver, kidney, skin and gastrointestinal tract. Interactions between glycogen concentrations in the liver and muscle with time after exercise showed that glycogen repletion occurred in the liver before muscle tissue. This effect was a unique finding and could explain in part the slow rate of glycogen repletion in muscle tissue that is characteristic for ruminants. Another major finding was an accumulation of glycogen concentration in skin during the recovery period after exercise. It was postulated that this effect may be due to the supply of glucose to glycolytic tissues being continued even when demand for glucose in the skin was low and the capacity to store glycogen in muscle was very high.
Experiment 3 confirmed the existence of a relationship between metabolisable energy (ME) intake and glycogen repletion in muscle tissues and found a slightly different relationship between ME intake and glycogen repletion in the liver tissue of lambs. Muscle glycogen concentration did not change in fasted lambs and the rate of glycogen repletion in muscle after exercise was dependent on ME intake. Differences were observed between different muscles, particularly between M. longissimus thoracis et lumborum (LTL) and all other muscles, in relation to the change in glycogen concentration with time after exercise. Glycogen concentrations changed less rapidly in the LTL than other muscles. Glycogen concentration in the liver was associated negatively with time after exercise in fasted lambs and positively with time after exercise in fed lambs.
Several experiments (Experiments 4, 5 and 6) were conducted to determine the affects of different nutritional factors on muscle glycogen concentration in lambs, both on farm and after commercial slaughter. These studies showed that short term increases in ME intake will increase muscle glycogen concentration to a maximum level over a period of about 7 days (Experiment 4). Diet composition did not affect the change in muscle glycogen concentration associated with an increase in ME intake although results from this experiment (Experiment 5) were not entirely conclusive. There was evidence that the type of feeding and finishing system may influence the susceptibility of muscle glycogen concentration to change during consignment of lambs to slaughter. Results from these experiments demonstrated that a goal for muscle glycogen concentration in lambs on farm of 1.5g/100g is quite achievable with contemporaneous management systems.
Finally this study highlighted the need for further research in a number of key areas in order that muscle glycogen concentration in lambs to be fully understood. In particular, the role of muscle glycogen turnover in relation to muscle glycogen concentration was noted as an area for which further research is warranted.
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Eisenberg, Ulrike. "Vom "Nervenplexus" zur "Seelenkraft" : Werk und Schicksal des Berliner Neurologen Louis Jacobsohn-Lask, 1863-1940 /." Bern : P. Lang, 2005. http://catalogue.bnf.fr/ark:/12148/cb40140485s.
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Monnier, Thomas Baboux Jean-Claude Guy Philippe. "Ondes de Lamb dans les milieux stratifiés application à la surveillance in situ et en temps réel de l'endommagement de structures composites /." [S.l.] : [s.n.], 2001. http://csidoc.insa-lyon.fr/these/2001/monnier/index.html.
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Scandelari, Luciano. "Génération et détection d'ondes de Lamb à l'aide de P(VF2-VF3) : application à la mesure de densités de liquides." Université Joseph Fourier (Grenoble ; 1971-2015), 1999. http://www.theses.fr/1999GRE10022.
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Au cours de ces travaux, nous avons effectué une étude théorique et expérimentale d'un dispositif à base de P(VF2-VF3) destiné à la génération des ondes de Lamb afin de mesurer des caractéristiques de liquides. L'essentiel de ce travail peut être résumé en trois points : En premier, la présentation d'une structure physique destinée à la génération et à la détection des ondes de Lamb sur des substrats non piézoélectriques, avec pour objectif des applications industrielles, parmi elles la mesure de densité de liquide en continu. Cette structure est constituée de deux lames piézoélectriques identiques d'épaisseur 90µm à base de P(VF2-VF3). Sur chaque lame est gravé un réseau d'électrodes métalliques. Le deuxième point a été la modélisation complète du dispositif, qui comprend la génération, la propagation et la détection de l'onde. Le troisième point a consisté à réaliser un système électronique dédié au contrôle de la génération et de l'acquisition du signal. Son avantage est l'intégration des fonctions génération et acquisition des signaux, ce qui facilite les mesures, et permet de déduire les paramètres de l'onde qui se propage entre les deux transducteurs. La partie logicielle qui pilote cette électronique utilise un algorithme de calcul du temps de vol entre l'onde émise puis détectée par le peigne récepteur. Dans la partie expérimentale, nous avons caractérisé l'influence de la température et de la densité d'un liquide sur les caractéristiques du mode a0 des ondes de Lamb se propageant dans une plaque d'aluminium. Si la vitesse longitudinale dans le liquide en contact avec la plaque est connue, nous pouvons donc utiliser ce dispositif pour mesurer la densité absolue des liquides avec une incertitude d'environ 5%
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Mild, Axel, and Arvid Mild. "Hållbar last mile distribution : Sustainable Last Mile Distribution." Thesis, Uppsala universitet, Industriell teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-418146.
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Syftet med examensarbetet är att utforma en distributionscentrals processer för identifiering, sortering och packning av gods, för att möjliggöra en hållbar last mile-distribution med cykel. Varulogistik i städer är en stor utmaning för att främja en hållbar stadsutveckling. Transporter är nödvändiga för att förse verksamheter och invånare med gods. Samtidigt bidrar dessa transporter till negativa miljöpåverkningar, i form av buller och utsläpp. Kommuner har en central roll i att främja en hållbar utveckling på grund av deras planmonopol och möjligheter att reglera trafiken. Ett sätt att minska tyngre trafik i innerstäder är genom införandet av mindre, energieffektiva distributionsfordon för last mile-leveranser av lättare paket. Studien bygger på en mix av kvalitativa och kvantitativa metoder. Intervjuer med experter inom området, samt studiebesök hos framgångsrika transportföretag har gett en bred kunskap i området. Tillgång till data inom nuvarande processer har dessutom hjälpt forma de två lösningsförslag som slutligen presenteras i studien. Resultatet av studien framkommer i två lösningsförslag, ett nutidsförslag och ett framtidsförslag. Nutidsförslaget innehåller förändringar i såväl nuvarande processer som införandet av nya. Förslagen som presenteras här är mindre resurskrävande att implementera och ses därför vara möjliga att genomföra i dag. Framtidsförslaget presenterar vidare förbättringar som kan tillämpas inom terminalens processer. Dessa förslag är mer resurskrävande. Trots att studien är utförd efter specifika önskemål från uppdragsgivaren täcker den relevanta områden som är av intresse för alla företag som vill implementera en last mile-lösning med hjälp av cykelfordon.
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Morris, Robert J. "A comparative study of the meaning and importance of several constitutional cases in the highest courts of the PRC, Hong Kong, & Taiwan." Thesis, Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B37678620.
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Pexton, Valerie. "Last dance." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1605161601&sid=2&Fmt=2&clientId=18949&RQT=309&VName=PQD.
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Elkins, Alan P. "Last Castle." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1242326601.
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Villegas, Megan A. "Last Rites." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1212086186.
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Haponek, Ken. "LAST MONDAY." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1180997881.
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Castillo, Alessandra, and Hernández David Rodríguez. "Work Labs." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/130137.
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Tesis para optar al grado de Magíster en AdministraciónCastillo, Alessandra (Parte I Análisis estratégico y de mercado ), Rodríguez Hernández, David (Parte II Análisis organizativo y financiero)
WorkLabs is a startup serviced office company that is dedicated to providing its members with a quality workspace, business solutions, and other services designed to satisfy all of their needs, so they can focus on excelling in their core business. Based in Santiago, Chile, WorkLabs aims to build a broad and loyal consumer base among small to mid-sized businesses that are looking to establish a presence in the city’s most important business hub. As both visionaries and users, the founders bring their industry experience, a diverse network of friends and colleagues from around the world, and their formal business knowledge together in order to solve a pressing need for most any business: a workspace that best fits their businesses needs, so they can focus on being the best in their respective fields. To be incorporated in Santiago, Chile, its founding members will each hold an equal stake in the company. David Rodríguez Hernández, a manager at On-Site/Facilities services giant Sodexo, and previously at consumer goods multinational Procter & Gamble, and Alessandra Castillo, associate director of Alumni Affairs and Corporate Giving, partnered to form WorkLabs. Additionally, an operational manager and sales manager will join the team, bringing experience and ideas that can help boost company growth from the start. WorkLabs provides a full range of services to businesses and individuals looking for a place to do business. We provide our “plug and play offices”, shared 100-megabit fiber-optic high-speed internet access, phone service with options for unlimited long distance, bilingual call management/messaging services (English/Spanish), along with a host of other services designed to create a productive and enjoyable workspace. The serviced office market has experienced tremendous growth worldwide, with Latin America exhibiting the highest percentage growth over the past year of any region worldwide, increasing by 37.5% with a net increase of 45 new centers in the region, the majority of the growth coming from Brazil and Mexico. The Chilean market has also seen tremendous increase in size, as companies like Regus, and other smaller competitors, attempt to establish a major presence in the country’s capital by establishing new centers. Although the serviced office market has grown tremendously, of the overall small to mid-size business market of size of USD $21B in sales, made up of 89,715 individual companies, and employing 464,455 people the serviced office market is still very much in its initial stages of growth, totaling an estimated 3,198 companies, a total market of $11,944MM. The outlook for the serviced office market is very promising, given the current size and growth rates of the market.
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Yao, Jing. "Characterization of Mechanical Properties of Thin-Film Li-Ion BatteryElectrodes from Laser Excitation and Measurements ofZero-Group Velocity Resonances." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7128.
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The mechanical properties of thin-film Li-ion battery electrodes are controlled by the micro structure of the constituent materials. In this work, a non-contact and non-destructive measurement of the mechanical properties of electrode films is performed by measurement of zero group velocity (ZGV) resonances. The ZGV Lamb wave modes of a solid bi-layer consisting of a thin metallic layer and a thin compliant coating layer are shown to be dependent on the Young's moduli, thicknesses, densities and Poisson ratios of the layers. Theoretical models are used to quantify the sensitivity of the ZGV resonances to changes in mechanical properties. Experimental ZGV resonances are excited using a pulsed infrared laser and detected using a laser interferometer. Commercial-grade battery films with different coating materials, densities and thicknesses are measured. Young's moduli of the battery electrode layers are estimated using the combination of a theoretical model and experimental results. The effect of the calendering process on the battery materials is also investigated. Results suggest that the Young's modulus of the electrode coating increases drastically after the battery films are calendered. This technique can be used to quantitatively study the mechanical properties of Li-ion battery electrodes to improve overall battery performance.
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Azevedo, Monica Klen de. "O narrador de Diário da Queda, de Michel Laub, e a representação da memória na narrativa contemporânea." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/130021.
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Esta dissertação tem como principal objetivo apresentar uma análise da obra Diário da queda, do autor gaúcho Michel Laub, percebendo como a literatura contemporânea une os tempos, representando não apenas o presente, mas, também, ligando-se à realidade histórica, a partir do resgate dos fatos com elementos fragmentários da memória de um passado criado a partir de marcas de identidade que definem o lugar do homem no mundo. Há anos, a literatura apresenta como passado e presente são ligados ao individual, e ao coletivo, através do testemunho de catástrofes como a Shoah. Percebendo a memória traumática – mesmo que não possa ser assimilada em sua totalidade tendo em vista a impossibilidade da compreensão do fato ocorrido – como tema de inúmeras obras literárias. O que é apresentado aqui são aspectos de três representações de memórias traumáticas partindo de três lembranças de personagens distintas que ligam traumas individuais a um trauma coletivo. Para isso, o presente trabalho está dividido em três partes. A primeira contextualiza a literatura brasileira contemporânea para que se perceba de que maneira a obra literária produzida na contemporaneidade está relacionada com seu próprio tempo. A segunda parte discorre sobre o narrador contemporâneo e a forma como esse narrador do pós-guerra reconstrói fatos a partir do distanciamento temporal. A terceira parte busca estabelecer uma ligação entre a literatura e a memória a fim de perceber os reflexos que a recordação tem nas narrativas ficcionais tendo como foco a análise da memória do narrador de Diário da queda, e a forma como esse narrador, descendente de judeus, utiliza-se de outros relatos para construir o seu. A partir das lembranças do pai – que, quando criança, fora traumatizado pelo abandono paterno e pela ausência de identidade nos relatos do avô do narrador, e, quando adulto, é abatido por uma doença que afeta a memória – e do avô – ex-prisioneiro do campo de concentração de Auschwitz que opta por uma visão otimista em seus escritos apesar de ter sido vítima de uma das maiores atrocidades da humanidade. A memória é o que constrói narrativa de Diário da queda representa o individual e o coletivo no contexto da contemporaneidade.This paper aims to present an analysis of the work Diário da queda, written by the author Michel Laub, realizing how contemporary literature unites the times, representing not only the present but also connecting to the historical reality, rescuing facts fragmentary elements of the memory of a past created from identity markers that define man's place in the world. For years, the literature presents how past and present are linked to individual, and collectivity, through the witness of disasters such as the Holocaust. Realizing the traumatic memory - even if it can not be assimilated in its entirety taking into account the impossibility of understanding the fact occurred - as the numerous literary works about the subject. What is presented in this paper are aspects of three representations of traumatic memories starting from three distinct characters of memories that connect individual trauma to a collective trauma. For this, the present work is divided into three parts. The first contextualizes contemporary Brazilian literature in order to realize how the literary work produced in contemporary times is related to its own time. The second part discusses the contemporary narrator and how that postwar narrator reconstructs facts from the temporal distance. The third part seeks to establish a connection between literature and memory in order to realize the consequences that the memory has the fictional narratives focusing on the analysis of Diário da queda memory, and how its narrator, a Jewish descent , makes use of other reports to build his own narrative. From his father's memories - that as a child, had been traumatized by paternal abandonment and lack of identity in the narrator's grandfather's stories, and as an adult, is shot down by a disease that affects memory - and grandfather - former prisoner of the Auschwitz concentration camp that follows an optimistic view in his writings despite having been the victim of one of the greatest atrocities of mankind. Memory is the building fall Diary of narrative is the individual and the collective in the contemporary context.
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Fuller, Matthew. "Transformer les capacités d'innovation : l'impact et l'influence des Fab Labs d'entreprise au sein de grands groupes Resetting innovation capabilities: the emergence of corporate fab labs Making nothing or something: corporate Fab Labs seen through their objects as they cross organizational boundarie Fitting squares into round holes: Enabling innovation, creativity, and entrepreneurship through corporate Fab Labs." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLED045.
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Inspirés par un modèle établi par une initiative sociale du Massachusetts Institute of Technology (MIT) en 2001, des salariés de plusieurs grandes groupes ont établi des Fab Labs d'entreprise avec l'intention de transformer les capacités d'innovation de leur entreprise.Cette thèse examine l'univers des Fab Labs entreprise, s'appuyant sur des données empiriques récoltées dans des dizaines de labs, avec des activités de recherche principales ayant lieu entre 2014 et 2017 dans les laboratoires de quatre grands groupes mondiaux. L'objectif de cette recherche est de 1) identifier si les Fab Labs d'entreprise influencent les capacités d'innovation d'une organisation, 2) articuler et affiner la représentation managériale utilisée pour justifier la création d'un tel lieu, ainsi que 3) esquisser un mécanisme simple qui permet aux décideurs stratégiques d'évaluer si les activités dans un lab lui permet d'atteindre ses objectifsBased on a pattern established by an MIT academic outreach program created in 2001, individuals in dozens of large organizations established corporate Fab Labs in recent years with the intent to transform their firm’s ability to innovate.This thesis investigates the world of corporate Fab Labs, building on empirical data gathered from dozens of labs, with core research activities taking place in the labs of four large multinational firms from 2014 through 2017. The purpose of this research is to 1) identify whether corporate Fab Labs influence an organization’s innovation capabilities, 2) articulate and refine the managerial representation used to support the creation of these labs, and 3) outline a simple mechanism for managers to evaluate whether a lab attains its desired outcomes
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Rytting, Matthew Charles. "Comparison of Simulation and Hands-On Labs in Helping High School Students Learn Physics Concepts." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6132.
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The purpose of the research was to determine whether PhET simulation labs or hands-on labs were more effective in helping students learn physics concepts. This measure was done by comparing quiz scores using recall, calculation, and transfer questions. Additionally, student perceptions of learning from both hands-on and simulation lab experiences were measured. Six labs were conducted with high school physics students on the topics of momentum, energy, circuits, angular momentum, pendulums, and friction. It was found that PhET simulation labs were as effective at creating student understanding, and sometimes more effective, as measured by quizzes given after the labs. Additionally, the survey data revealed that students were more engaged by hands-on lab experiences, and viewed the hands-on labs to be more effective than the simulation labs.
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Johnson, Mont A. "Investigation of the mechanical properties of copy paper using laser generated and detected lamb waves." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16730.
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Al-Mauly, N. Z. N. "The 'ram effect' and the occurrence of puberty and reproductive performance in ewe lambs." Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380850.
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Cunningham, James M. "Maturation of Sertoli cell sectretory function during sexual development of the lamb." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255976.
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Torgerson, Paul Robert. "The development of the immune response to antigens of Haemonchus." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259605.
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Oddy, V. H. "Muscle protein metabolism : Measurement and manipulation in lambs." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382662.
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Nachtsheim, Stephan. "Emil Lasks Grundlehre /." Tübingen : J.C.B. Mohr, 1992. http://catalogue.bnf.fr/ark:/12148/cb35602055v.
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Li, Feng. "Innovative detection methods in liquid for a lamb wave biosensor." Besançon, 2008. http://www.theses.fr/2008BESA2019.
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The fields of health care and environment control have an ever increasing demand for sensors which are able to detect low concentrations of particIes such as molecular agents, warfare agents, or solid particIes contained in gaseous or liquid samples. The acoustic sensors, with rapid response, portability, ease of use, and small size are promising typically to be used in recognition of antigens by specific antibodies, absorption of proteins on chemical tailored surfaces, etc. Among the acoustic sensors, Lamb wave sensor is more attractive in biochemical applications for its higher sensitivity and ability to work in liquid. Further more, in the thesis it is found that Lamb wave sensor has the potential for multi parameters measurement at the same time. In this thesis, the Lamb membrane is modeled and the numerical simulations of Lamb wave are realized by FEM. These methods can be applied to Lamb wave simulation on complex geometries with complicated boundary conditions. The simulation results will help to design and optimize Lamb wave sensor for us. The design and fabricating for stable and reproducible Lamb wave sensor is investigated. The first improvement to the Lamb wave devices is using Mo/Ti/Si as AIN deposition substrate rather than Al/Si. Secondly, the problem of fragility of high sensitive Lamb wave sensor has been successfully solved by minimizing the inner stress. After the Lamb wave devices are fabricated out, the performances of Lamb wave devices are investigated comprehensively, including the frequency response, the delay of Lamb wave and the vibration of the membrane. .Les domaines de la santé et du contrôle de l'environnement ont une demande croissante de capteurs capables de détecter de faible quantité d'agents toxiques ou de particules solides dans des gaz ou des liquides. Les capteurs acoustiques, avec leur réponse rapide, leur portabilité, leur utilisation aisée et leurs petites tailles sont typiquement prometteurs pour la reconnaissance d'anticorps par des antigènes spécifiques ou l'absorption de protéines sur des surfaces préparées. Le principe de détection de ces capteurs utilise la variation de fréquence de la résonance d'une onde. Parmi les capteurs acoustiques, le capteur à ondes de Lamb semble le mieux placé pour les applications biochimiques, en raison de sa sensibilité et de son aptitude à fonctionner dans un liquide. De plus, dans cette thèse, nous montrerons que les capteurs à ondes de Lamb ont la possibilité de mesurer plusieurs paramètres simultanément. Dans cette thèse, l'onde de Lamb a été modélisée et des simulations numériques ont été effectuées par la méthode des éléments finis. Ces méthodes peuvent être appliquées aux ondes de Lamb pour des géométries et des conditions aux limites complexes. Les résultats de la simulation nous aident à concevoir et optimiser les capteurs à ondes de Lamb. Nous avons développé la conception et la fabrication de capteur à ondes de Lamb. La première amélioration a été d'utiliser pour le dépôt d'AIN des couches Mo/Ti/Si plutôt que Al/Si. La seconde a porté sur la réduction des contraintes internes de la membrane. Après sa fabrication, le capteur à ondes de Lamb a été étudié complètement, y compris la réponse en fréquence, la durée de propagation des ondes et la vibration de la membrane. .
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Zhou, Lianqun. "Study of the membrane-fluid interaction in micro lamb wave sensor." Besançon, 2010. http://www.theses.fr/2010BESA2041.
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Micro lamb wave sensor is one of useful tools to study the membrane-fluid interaction, especially in interdisciplinary and not yet explored areas, such as gas sensing, aerodynamics, the multi-parameter decoupling and so on. This is because micro Lamb wave sensor holds high sensitivity, low losses and multi-modes. This thesis deals with the membrane-fluid interaction with micro lamb wave sensor is investigated, and the potential function method is used to analyze the dispersion curves, the displacements, the stress curves, etc. A model is built to analyze the modes distribution in micro Lamb wave sensor. The gase effects on lamb wave propagations are investigated. The applications of Lamb wave in aerodynamics and multi-parameters decoupling are discussed. The details are described as follows. In theory, combinations of the potential function method and the boundary conditions at all interfaces are used to analyze the membrane-fluid interaction. Compared with traditional plate shell theory, the particle movements in the membrane and fluid are taken into account in this method. Several aspects of the problem can be addressed, including the displacement, the stress, velocity dispersion curve, pointing vector, group velocity, energy velocity and so on. All of these are available to investigate the interaction at the membrane-fluid interface. In the case of micro Lamb wave sensor, the resonant modes can be excited and work simultaneously with the travelling modes, as the membrane is width limited and not large enough comparing with the wavelength of Lamb waves. The established model car reveal the mode distributions in micro Lamb wave device clearly and accurately. These works provide insight into the understandings of the modes in micro Lamb wave device, which is useful for further experiments. In literatures, little attention has been paid on the Lamb wavesۥ propagation near the membrane-gas interface, as both the density and sound velocity of gas are low. We aim to provide more studies of gases effects on the evanescent wave the leaky wave near the membrane-gas interface. It is shown that the relative frequency shifts in the low frequency range of the A0 mode (evanescent wave, EW) is rather important and the shape of the curve looks like ۥUۥ shape; in the high frequency range of this mode (leaky Lamb wave, LLW), the quality factor decreases rapidly when the Lamb wave phase velocity approaches the gas sound velocity. The Sº mode shows immune to gas loading, which is a good choice for a reference mode. This provides theoretical and experimental work for related fields in gas sensing. The application of membrane-gas interaction in aerodynamics in investigated theoretically and experimentally. The interaction between the gas flow boundary layer and the acoustic sound field (EW and LLW) at the membrane-gas interface can give out the parameter in the gas flow. The parameters in gas flow can be obtained from the measuring the interaction, which happens between the gas flow boundary layer and the acoustic sound field (EW and LLW) at the membrane gas interface. In the EW case, the thicknesss of the gas flow boundary layer and the penetration depth of the evanescent wave combined determine this interaction. When the Lamb wave phase velocity approaches the gas sound velocity, this effect is clearly observed. In the LLW case, it is shown experimentally that the gas flow has not evident effects on Lamb wave’s propagations. It suggests that Lamb wave is promising for applications in wind tunnel experiments, micro channels characterization, and can lead to multi-parameters measurements. The effects of the different physical parameters (density, sound velocity, viscosity, etc) on the modesۥ propagations at he membrane-liquid interface are studied. Combination of the relative frequency shifts of the A01 mode (he fundamental mode of low frequency A0 mode) and the A03 mode (the third harmonic wave of the A01 mode), the density and the sound velocity of liquid, but is amplitude changes with the viscosity. This work makes Lamb wave have promising applications in the investigation of the molecular thermodynamics, molecular labels free detection,etcCette thèse traite, théoriquement et expérimentalement, de l’interaction fluide-membrane dans un capteur a onde de Lamb. Un modèle est utilisé pour calculer les courbes de dispersion, le déplacement, les contraintes. Un autre modèle est utilisé pour analyser la distribution des modes. L’effet des gaz est étudié théoriquement et expérimentalement. Les applications des ondes de Lamb à l’aérodynamique et aux mesures multiparamétriques sont présentées. Voici quelques détails. Le premier modèle utilise les fonctions potentielles et recherche les fonctions solution des équations de propagation qui remplissent les conditions aux limites avec ou sans la présence d’un liquide. Ce modèle permet d’obtenir de nombreux paramètres, le déplacement des particules, les contraintes, le vecteur de Poynting, les vitesses de groupe et d’énergie etc. La membrane étant limitée dans le sens latéral il y a coexistence dans la membrane de modes stationnaires et d’ondes progressives. Un modèle donne la position et l’intensité relatives des modes. Le but est d’apporter des connaissances complémentaires sur l’action des gaz sur la propagation des ondes de Lamb. On montre que pour les basses fréquences de A0 (ondes évanescentes dans le gaz) l’action est principalement un changement de fréquence , tandis aux plus hautes fréquences de A0 (Ondes «fuyantes» l’action est principalement une atténuation. Le S0 mode étant très peu modifié par la présence de gaz. L’application de l’interaction gaz-membrane en aérodynamique est étudiée théoriquement et expérimentalement. Le principal effet ce produit quand la vitesse de phase de l’onde de Lamb est proche de la vitesse du son dans le gaz. Les résultats suggèrent que les applications dans ce domaine seront très prometteuses. Les effets sur l’onde de Lamb de différents paramètres (densité, vitesse du son viscosité) d’une solution liquide sont étudiés. On montre que l’utilisation conjointe de A01 mode (fondamental du A0 mode) et du A03 mode (harmonique 3 DU A0 mode) permet de mesurer la densité et la vitesse du son. La densité étant connue, le S0 mode permet d’obtenir la viscosité
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Wilkie-Chancellier, Nicolas. "Réflexion et conversion d'une onde de Lamb à l'extémité biseautée d'une plaque." Le Havre, 2003. http://www.theses.fr/2003LEHA0006.
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Ce travail est consacré à l'étude de l'interaction d'ondes de Lamb avec un biseau. L'objectif est d'identifier les différents modes propagatifs issus de la conversion de l'onde incidente sur l'extémité biseautée d'une plaque et d'évaluer l'énergie transportée par chaque mode. Dans un premier temps, cette étude est réalisée expérimentalement sur une plaque d'acier inoxydable. Les bilans d'énergie sont déduits des mesures des déplacements en surface par interférométrie laser. Ils sont corrigés pour tenir compte de la diffraction des ondes ultrasonores. Un modèle théorique, basé sur une décomposition modale, est ensuite mis en oeuvre afin de justifier les résultats précédents. Le calcul des coefficients de réflexion en énergie a été mené dans le cas des modes de Lamb A0, S0 et A1 incidents sur des extrémités biseautées de 65 à 90°pour un produit fréquence-épaisseur FE variant de 1 à 4 MHz. Mm. Les bilans quantitatifs obtenus par cette méthode valident les résultats expérimentaux. Le calcul théorique met en évidence l'importance des "modes complexes" existant dans la plaque. Une simulation par éléments finis a montré leur influence sur les réflexions et a permis d'évaluer à quelle distance du biseau les modes de Lamb se propagent seuls. Enfin, une étude est effectuée pour décrire l'influence d'un biseau sur le comportement du "mode de bout", phénoène particulier pouvant se produire à l'extrémité d'une plaque dans une gamme fréquentielle étroite lorsque le mode de Lamb S0 est incidentThis study deals with the Lamb wave interaction on a bevel. The aim is to identify the different reflected modes which exist when a wave is incident on the bevelled end of a plate and to evaluate the respective energy of each mode. In a first time, the study is experimentally realised on a stainless steel plate. Energy balances are performed from the displacement measurements on the surface by laser interferometry. They are corrected to take into account wave diffraction. A theoretical model, based on a modal decomposition, is also done in order to justify the previous results. Computations of the energy reflection coefficients have been realised when the A0, S0 and A1 Lamb modes are incident on plate ends bevelled from 65 to 90°, for a frequency-thickness product included between 1 and 4 MHz mm. The quantitative balances obtained by this method agree with the experimental results. The theoretical computation reveals the importance of "complex modes" at the plate extremity. A finite element simulation confirms their effect on the reflections and allows to evaluate the distance from the bevel where the reflected Lamb waves are alone. Finally, a study is done to know the influence of a bevel on the "edge mode" behaviour - the "edge mode" is a particular phenomenon which appears in a narrow frequency band when the S0 Lamb mode is incident
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Shaw, Anurupa. "Ice thickness estimation using low frequencies, and an investigation of diffraction of sound in samples with micro structures using ultrasound." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54242.
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In the first section, the thickness of ice on the lakes and canals is estimated by analyzing the sound spectrum generated by dispersion of Lamb type waves propagating in ice. In winters when the lakes and canals freeze, it is important to know the thickness of the ice layer before setting foot on it. When a stone is thrown on the ice layer, a fluting sound can be heard. This is recorded for different thicknesses of ice, and the sound spectrum is compared with the results simulated using a parameterized model. This model is created using a combination of plane waves for different incident angles and frequencies to generate dispersion curves for different thicknesses of ice. The frequencies of the reflected sound are then compared with the frequencies of musical instruments in order to assign different musical notes to different thicknesses of ice. The technique enables thickness estimation without the use of specialized equipment or time consuming drilling and may therefore be of practical value in the preservation of the lives of ice skaters and playing children. In the second half of the study, high frequencies (400 MHz and 1 GHz) are used to investigate samples with micro structures. Acoustic microscopy is a well established technique as far as smooth surfaces are concerned. V (z) curves are obtained from which, through surface wave generation, important features concerning elasticity and related properties can be extracted. Recently, high resolution imaging using high frequency focused transducers, based on acoustic microscopy has appeared. The surface profiles of the samples used in this study, have periodic structures but lack smoothness. The periodicity causes sound diffraction and the roughness influences the acoustic microscopic investigation. The small acoustic contrast between the substrate and the periodic corrugation on the material, gives us information about the additional stresses which develop and affect the bonding between the two materials. In this study, experiments are conducted using samples with corrugations of different periodicity, and a comparison is made between the results for smoother surfaces and results for the periodic structures of the same material. An attempt is made to analyse the effects described above.
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Batticuore, Graciela. "Las lectoras y las novelas." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/113789.
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