Relevant bibliographies by topics / Laser delivery probe

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Laser delivery probe'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Laser delivery probe"

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Hopko, Sandra N., I. Charles Ume, and Dathan S. Erdahl. "Development of a Flexible Laser Ultrasonic Probe." Journal of Manufacturing Science and Engineering 124, no. 2 (April 29, 2002): 351–57. http://dx.doi.org/10.1115/1.1379369.

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Ultrasonics is a widely used nondestructive testing technique, which is often applied off-line for weld quality inspection. Laser ultrasonic (LU) inspection systems have the potential for on-line application, providing the means to identify unacceptable welds as they are formed. Because LU systems are non-contacting, they can be used for testing moving specimens or for operation in hazardous and/or high temperature environments. A highly versatile system can be created when an optical fiber delivery system is incorporated into the design. Introduction of a focusing objective increases the allowable working distance and permits stronger generation using material ablation as the generating mechanism. This paper describes the development of a laser ultrasonic probe using an optical fiber delivery system with a distal end, focusing objective. The optical fiber delivery system can be configured as a single fiber source, a linear array (fiber bundle) or a phased array. Results include experimentally obtained directivity patterns demonstrating ultrasonic generation using ablation sources. Thermoelastic source results are also included. This paper demonstrates the potential of the fiber tool and presents an overview of the weld control scheme.
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Weierstall, Uwe. "Liquid sample delivery techniques for serial femtosecond crystallography." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1647 (July 17, 2014): 20130337. http://dx.doi.org/10.1098/rstb.2013.0337.

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X-ray free-electron lasers overcome the problem of radiation damage in protein crystallography and allow structure determination from micro- and nanocrystals at room temperature. To ensure that consecutive X-ray pulses do not probe previously exposed crystals, the sample needs to be replaced with the X-ray repetition rate, which ranges from 120 Hz at warm linac-based free-electron lasers to 1 MHz at superconducting linacs. Liquid injectors are therefore an essential part of a serial femtosecond crystallography experiment at an X-ray free-electron laser. Here, we compare different techniques of injecting microcrystals in solution into the pulsed X-ray beam in vacuum. Sample waste due to mismatch of the liquid flow rate to the X-ray repetition rate can be addressed through various techniques.
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Ashley, S., S. G. Brooks, A. A. Gehani, R. C. Kester, and M. R. Rees. "Thermal characteristics of sapphire contact probe delivery systems for laser angioplasty." Lasers in Surgery and Medicine 10, no. 3 (1990): 234–44. http://dx.doi.org/10.1002/lsm.1900100304.

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Lesinski, S. George, and Kylie Giesken. "Optical Fiber for CO2 Laser Otosclerosis Surgery." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P57. http://dx.doi.org/10.1016/j.otohns.2008.05.184.

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Objective To determine the safety and efficacy of new handheld optical fibers for CO2 laser stapedotomy and stapedectomy revision. Advantages of the new CO2 optic fibers are: convenience, reliability and precision. Disadvantages are: special adaptor required for laser console, limited spot size and cost. Omniguides’ handheld optic fibers introduce a safe, effective, and precise delivery system for CO2 laser otosclerosis surgery. Methods Prospective study of 25 consecutive otosclerosis patients. Researchers at Massachusetts Institute of Technology have developed a flexible optical fiber (photonic bandgap reflector) which can deliver CO2 laser energy through a handheld probe with minimal loss of laser energy. Omniguide introduced a 0.9 mm (O.D.) fiber in 2007 specifically for otologic surgery. This clinical study analyzes the safety and effectiveness of this new technology for CO2 laser otosclerosis surgery. To determine appropriate energy parameters, stapedotomy was performed in the laboratory on human temporal bones. Subsequently, 25 consecutive otosclerosis patients underwent CO2 laser stapedotomy (21) or stapedectomy revision (4) employing these handheld fibers. 6-month post op audiograms were analyzed for air/bone gaps and nerve loss according to AAO-HNS guidelines. Results 21/21 primary and 3/4 revision patients closed the air/bone gap to within 15 decibels (mean 0.5, 1, 2, 3 KHz). There was no nerve loss at these frequencies. Three patients demonstrated a slight loss at 4 KHz (2–15 db, 1–20 db) compared with their preop audiograMS These results compare favorably with previous otosclerosis surgery performed by the author with microscope mounted CO2 lasers. Conclusions Advantages of the new CO2 optic fibers are: convenience, reliability and precision. Disadvantages are: special adaptor required for laser console, limited spot size and cost. Omniguides’ handheld optic fibers introduce a safe, effective and precise delivery system for CO2 laser otosclerosis surgery.
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Dadey, David Y. A., Ashwin A. Kamath, Matthew D. Smyth, Michael R. Chicoine, Eric C. Leuthardt, and Albert H. Kim. "Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series." Neurosurgical Focus 41, no. 4 (October 2016): E4. http://dx.doi.org/10.3171/2016.7.focus16207.

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OBJECTIVE The precision of laser probe insertion for interstitial thermal therapy of deep-seated lesions is limited by the method of stereotactic guidance. The objective of this study was to evaluate the feasibility of customized STarFix 3D-printed stereotactic platforms to guide laser probe insertion into mesiotemporal and posterior fossa targets. METHODS The authors conducted a retrospective review of 5 patients (12–55 years of age) treated with laser interstitial thermal therapy (LITT) in which STarFix platforms were used for probe insertion. Bone fiducials were implanted in each patient's skull, and subsequent CT scans were used to guide the design of each platform and incorporate desired treatment trajectories. Once generated, the platforms were mounted on the patients' craniums and used to position the laser probe during surgery. Placement of the laser probe and the LITT procedure were monitored with intraoperative MRI. Perioperative and follow-up MRI were performed to identify and monitor changes in target lesions. RESULTS Accurate placement of the laser probe was observed in all cases. For all patients, thermal ablation was accomplished without intraoperative complications. Of the 4 patients with symptomatic lesions, 2 experienced complete resolution of symptoms, and 1 reported improved symptoms compared with baseline. CONCLUSIONS Customized stereotactic platforms were seamlessly incorporated into the authors' previously established LITT workflow and allowed for accurate treatment delivery.
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Li, Yuchao, Hongbao Xin, Chang Cheng, Yao Zhang, and Baojun Li. "Optical separation and controllable delivery of cells from particle and cell mixture." Nanophotonics 4, no. 3 (November 6, 2015): 353–60. http://dx.doi.org/10.1515/nanoph-2015-0008.

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Abstract Cell separation and delivery have recently gained significant attention in biological and biochemical studies. In thiswork, an optical method for separation and controllable delivery of cells by using an abruptly tapered fiber probe is reported. By launching a laser beam at the wavelength of 980 nm into the fiber, a mixture of cells with sizes of ~5 and ~3 μm and poly(methyl methacrylate) particles with size of 5 μm are separated into three chains along the direction of propagation of light. The cell and particle chains are delivered in three dimensions over 600 μm distance. Experimental results are interpreted by numerical simulations. Optical forces and forward migration velocities of different particles and cells are calculated and discussed.
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Calzavacca, Paolo, Roger G. Evans, Michael Bailey, Rinaldo Bellomo, and Clive N. May. "Variable responses of regional renal oxygenation and perfusion to vasoactive agents in awake sheep." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 10 (November 15, 2015): R1226—R1233. http://dx.doi.org/10.1152/ajpregu.00228.2015.

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Vasoactive agents are used in critical care to optimize circulatory function, but their effects on renal tissue oxygenation in the absence of anesthesia remain largely unknown. Therefore, we assessed the effects of multiple vasoactive agents on regional kidney oxygenation in awake sheep. Sheep were surgically instrumented with pulmonary and renal artery flow probes, and combination fiber-optic probes, in the renal cortex and medulla, comprising a fluorescence optode to measure tissue Po2 and a laser-Doppler probe to assess tissue perfusion. Carotid arterial and renal venous cannulas enabled measurement of arterial pressure and total renal oxygen delivery and consumption. Norepinephrine (0.1 or 0.8 μg·kg−1·min−1) dose-dependently reduced cortical and medullary laser Doppler flux (LDF) and Po2 without significantly altering renal blood flow (RBF), or renal oxygen delivery or consumption. Angiotensin II (9.8 ± 2.1 μg/h) reduced RBF by 21%, renal oxygen delivery by 28%, oxygen consumption by 18%, and medullary Po2 by 38%, but did not significantly alter cortical Po2 or cortical or medullary LDF. Arginine vasopressin (3.3 ± 0.5 μg/h) caused similar decreases in RBF and renal oxygen delivery, but did not significantly alter renal oxygen consumption or cortical or medullary LDF or Po2. Captopril had no observable effects on cortical or medullary LDF or Po2, at a dose that increased renal oxygen delivery by 24%, but did not significantly alter renal oxygen consumption. We conclude that vasoactive agents have diverse effects on regional kidney oxygenation in awake sheep that are not predictable from their effects on LDF, RBF, or total renal oxygen delivery and consumption.
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Ashley, S., S. G. Brooks, A. A. Gehani, R. C. Kester, and M. R. Rees. "Percutaneous laser recanalisation of femoropopliteal occlusions using continuous wave Nd-YAG laser and sapphire contact probe delivery system." European Journal of Vascular Surgery 8, no. 4 (June 1994): 494–501. http://dx.doi.org/10.1016/s0950-821x(05)80971-5.

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Liu, Xiaole, Jie Yuan, Dong Wu, Xiaobin Zou, Qing Zheng, Weina Zhang, and Hongxiang Lei. "All-optical targeted drug delivery and real-time detection of a single cancer cell." Nanophotonics 9, no. 3 (December 5, 2019): 611–22. http://dx.doi.org/10.1515/nanoph-2019-0318.

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AbstractTargeted drug delivery and real-time detection both play an important role for studying the specificity of a single cancer cell and the development of anticancer drugs. However, a method that simultaneously enables safe and efficient targeted drug delivery and noninvasive, free-label cell detection is highly desirable but challenging. Here, we report an all-optical method that combines fiber optical tweezers with laser Raman microspectroscopy, which can achieve targeted drug delivery to a single cancer cell using optical manipulation in vitro quickly and accurately by a tapered fiber probe, and simultaneously record the corresponding active characteristics of the targeted cancer cell under the contact of delivered drug through a Raman spectrometer. Using the method, drug delivery and release can be flexibly controlled by turning on/off the trapping laser beam propagating in the fiber, which can avoid the complex systems and is highly autonomous and controllable. Moreover, the detection of cell activity does not require any dye calibration and processing, and it is noninvasive. In addition, for a single suspension cell, optical trapping of the cell using another fiber tip can overcome the low efficiency of targeted drug delivery and the poor stability of the Raman spectrum caused by Brownian motion of the cell. This all-optical method provides a promising approach to conduct pharmacologic studies with the reaction of cancer cell and drugs at the level of a single cell.
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Brennan, James F., George I. Zonios, Thomas D. Wang, Richard P. Rava, Gary B. Hayes, Ramachandra R. Dasari, and Michael S. Feld. "Portable Laser Spectrofluorimeter System for in Vivo Human Tissue Fluorescence Studies." Applied Spectroscopy 47, no. 12 (December 1993): 2081–86. http://dx.doi.org/10.1366/0003702934066505.

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A compact, portable spectrofluorimeter which measures broad-band fluorophores with high sensitivity is described. This instrument is specifically designed for acquisition of human tissue autofluorescence spectra in vivo. Pulsed excitation laser light at 337 nm and in the 370–700 nm wavelength range is provided, and the resulting fluorescence can be measured with 10-nm resolution. The system produces single-pulse spectra in human artery wall tissues with a signal-to-noise ratio of 100:1. An optically shielded fiber-optic probe for light delivery and collection permits calibrated intensity information to be obtained.
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Dissertations / Theses on the topic "Laser delivery probe"

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Σιδερούδη, Θεοχαρία. "Φασματοσκοπική μελέτη οφθαλμικών παθήσεων και ανίχνευση μορίων φαρμάκων." Thesis, 2006. http://nemertes.lis.upatras.gr/jspui/handle/10889/1472.

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Η φασματοσκοπία Raman είναι τεχνική ανελαστικής σκέδασης φωτός, ικανή να ανιχνεύει και να χαρακτηρίζει μόρια σε ποικιλία υδατικών διαλυμάτων. Σκοπός της εργασίας είναι η ανάπτυξη μιας μη επεμβατικής, μη καταστροφικής φασματοσκοπικής μεθόδου για την ανίχνευση και τον ποσοτικό προσδιορισμό τόσο φαρμακευτικών ουσιών (π.χ αντιβιοτικών) όσο και φυσιολογικών ουσιών (π.χ γλυκόζη) στο υδατοειδές υγρό οφθαλμού. Στο πλαίσιο της παρούσας εργασίας αναπτύχθηκε μια νέα γεωμετρική οπτική διάταξη για την καθοδήγηση της δέσμης του laser στον οφθαλμό, που προσαρμόζεται σε φασματοσκόπιο Raman με ανιχνευτή CCD, δίνει τη δυνατότητα επιλεκτικής συλλογής του σκεδαζόμενου φωτός, σαρώνοντας τον εμπρόσθιο θάλαμο, σε γεωμετρία σκέδασης 90 μοιρών. Τα πειράματα πραγματοποιήθηκαν (α) σε χοιρινούς οφθαλμούς in-vitro, max 24 ώρες μετά τη θανάτωση των ζώων και την αφαίρεση του βολβού, μετά την έγχυση στον εμπρόσθιο θάλαμο μορίων κεφταζιδίμης, αμφοτερισίνης Β και γλυκόζης και (β) σε μοντέλο πρόσθιου θαλάμου (AAC) σε συνδυασμό με κερατοειδή χιτώνα χοιρινών οφθαλμών μετά την έγχυση μορίων κεφταζιδίμης, αμφοτερισίνης, θειικής αμικασίνης και σιπροφλοξασίνης. Επιπλέον, χρησιμοποιήθηκε χημειομετρικός αλγόριθμος μερικών ελαχίστων τετραγώνων (PLS) για να προβλέψει τη συγκέντρωση των αντιβιοτικών στο μοντέλο του πρόσθιου θαλάμου. Με τον νεό αυτό σχεδιασμό αποφεύγεται η απευθείας έκθεση βασικών οφθαλμικών ιστών, όπως του φακού και του αμφιβληστροειδούς, στη δέσμη του laser, ενώ παράλληλα επιτυγχάνονται βέλτιστες συνθήκες συλλογής του σκεδαζόμενου φωτός βελτιώνοντας το λόγο σήματος/θορύβου των φασμάτων. Ανιχνεύτηκαν συγκεντρώσεις στην περιοχή της μέσης ανασταλτικής πυκνότητας για τα αντιβιοτικά τόσο στο υδατοειδές υγρό χοιρινών οφθαλμών όσο και στο μοντέλο του πρόσθιου θαλάμουֹ η γλυκόζη ανιχνεύτηκε σε συγκέντρωση κοντά στα παθολογικά επίπεδα των διαβητικών ασθενών. Με βάση και το σφάλμα RMS της ποσοτικής ανάλυσης PLS, προσδοκάται βάσιμα ότι η μέθοδος είναι δυνατό χρησιμοποιηθεί στον τομέα της οφθαλμολογίας για τη μελέτη της φαρμακοκινητικής καθώς και για την έγκαιρη διάγνωση ασθενειών (π.χ. σακχαρώδης διαβήτης).
Laser Raman spectroscopy is an inelastic light scattering technique able to characterize molecules in aqueous environments. The purpose of this work is to develop a non-contact and non-invasive spectroscopic method to identify and eventually quantify the presence of medicines (e.g. antibiotics) and physiological substances (e.g. glucose) in the aqueous humor of the eye. Α new laser light delivery probe has been developed and adapted to a Raman spectroscopic system with the ability of favorable collection of the Raman light at 90o scattering geometry while scanning the anterior chamber of the eye. The technique is applied both, to porcine eyes in-vitro, max. 24 hours after death and extraction, for ceftazidime, amphotericin B and glucose and to a commercially available artificial anterior chamber (AAC) fitted with corneas of porcine eyes for ceftazidime, amphotericin B, amikacin sulphate and ciprofloxacin. Finally, a PLS chemometric algorithm has been developed to predict the concentration of antibiotics in AAC. This special illumination design gives the opportunity of reducing the direct exposure of the basic cordial ocular tissues, like lens and retina, to the laser beam, while at the same time an optimum collection of scattered light is accomplished. Concentrations close to the minimum inhibitory concentration (MIC) have been detected for antibiotics both in porcine eyes and AAC; the detection of glucose has been realized at concentrations close to the early pathological levels of patients with diabetes. Furthermore, the quantification of concentration of antibiotics in AAC is accomplished by a partial least-squares (PLS) chemometric regression algorithm and the RMS error of the validation procedure further emphasize the promising prospect of the application of the Raman spectroscopy to the Ophthalmology.
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Books on the topic "Laser delivery probe"

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Thomas, Emily. Later British Reactions to Absolutism: 1690–1704. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198807933.003.0009.

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This chapter considers British reactions to absolutism between the 1690 publication of Locke’s Essay and the 1704 delivery of Clarke’s Boyle lectures. These reactions tended to focus on absolutism about space rather than time, and they were extremely mixed. Thinkers such as William King, Joseph Raphson, Richard Bentley, and John Keill adopt absolutism about time, duration, or space. Their absolutisms draw on various sources, including Gassendi, Henry More, and Newton. Of these absolutisms, the Newtonian strain would prove the most influential. In contrast to these early advocates, thinkers such as Richard Burthogge, John Sergeant, and John Toland reject absolutism, advancing a variety of metaphysical and theological worries.
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Book chapters on the topic "Laser delivery probe"

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Mayer, R. G. "The Impracticability of Latin ‘Kunstprosa’." In Aspects of the Language of Latin Prose. British Academy, 2005. http://dx.doi.org/10.5871/bacad/9780197263327.003.0009.

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This chapter provides a discussion that aims to offer some account of the impracticability of Latin ‘Kunstprosa’. It begins by presenting the quandary of Vitruvius. Vitruvius showed a thorough competence; his intellectual predecessors in the later Republic had provided a lesson in the logical grouping of topics, a lesson he learnt. Vitruvius’ quandary can be explained by the failure of Latin prose to provide the educated writer with workable models of sound prose style. The chapter then inspects the masters themselves, Cicero and Caesar. The period in Cicero’s oratorical prose is deemed to be generally above reproach, once allowance is made for his increasing assurance. The issue of anacoluthon in Cicero’s philosophical writings was considerably discussed at the time this essay was delivered, and in subsequent e-mail exchanges with Jaap Wisse. The chapter then turns to Cicero’s only real successor, Livy. Moreover, the origin and use of the period in formal Latin style are described.
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Blechman, Elaine A. "Disability Determinations and Personal Health Records." In Patient-Centered E-Health, 60–69. IGI Global, 2009. http://dx.doi.org/10.4018/978-1-60566-016-5.ch005.

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Newly disabled workers are often unemployed, uninsured, and indigent. They are in desperate need of Social Security OASDI monthly benefits, and the Medicare health insurance that follows 24 months after benefits begin. Applicants must prove that their medical conditions (excluding drug and alcohol abuse) have resulted in severe functional limitations that prevent them from any gainful employment. Delays and denials of benefits result when applicants cannot find or retrieve medical records from providers familiar with their medical history, health status, and functional limitations. The disability application workflow is complex, particularly for applicants with cognitive and mental health impairments. Health information technology (HIT) has been used to automate care delivery workflow through provider-controlled, electronic health record systems (EHRs). Disability applicants’ workflow could, just as well, be automated through consumer-controlled, unbound, and intelligent personal electronic health record systems (PHRs), which are not tethered to a health plan or employer network, and which automatically exchange information updates with authorized providers’ EHRs. Applicants’ PHRs may later prove helpful with self-management of chronic conditions prior to Medicare coverage and with periodic reevaluations of their medical status.
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Conference papers on the topic "Laser delivery probe"

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Joos, Karen M., Jin-Hui Shen, and Qiushi Ren. "Endoscopic goniotomy probe for holmium:YAG laser delivery." In OE/LASE '94, edited by Jean-Marie A. Parel and Qiushi Ren. SPIE, 1994. http://dx.doi.org/10.1117/12.178563.

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Jones, Mark S., and Matthew A. Thomas. "Development and clinical application of a fiber optic laser delivery probe for subretinal endophotocoagulation." In Photonics West '95, edited by Jean-Marie Parel, Qiushi Ren, and Karen M. Joos. SPIE, 1995. http://dx.doi.org/10.1117/12.209863.

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Viator, John A., Guillermo Aguilar, Steven L. Jacques, and J. Stuart Nelson. "Optimization of Cryogen Spray Cooling for Port Wine Stain Laser Therapy Using Photoacoustic Measurement of Epidermal Melanin." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43169.

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Treatment of vascular skin lesions, such as port wine stain (PWS) birthmarks, uses laser energy to thermally damage the hypervascular regions in the dermis. Delivery of sufficient laser energy to the dermis can be confounded by the more superficial epidermal melanin layer, a broadband optical absorber. Laser pulses directed at skin lesions may result in excessive heating and scarring of the epidermis, resulting also in limiting the energy available to treat the dermal lesion. Cryogen spray cooling is used to selectively cool the epidermis, allowing the use of higher laser fluences which cause thermal damage in the deeper lesion, while preventing hypertrophic scarring of the epidermis. In order to optimize cryogen cooling and laser pulse parameter for treatment, the depth profile of the epidermal melanin layer and vascular lesion must be known. We use a photoacoustic probe to determine this depth profile. A Q-switched Nd:YAG laser emitting 532 nm light pulses of 4 ns duration is used to excite acoustic waves in epidermal melanin and hemoglobin in the vascular lesions via a miniature probe incorporating a piezoelectric detector. We used acoustic propagation time to determine the spatial relationship of the absorbing structures, thereby giving the necessary means to determine cryogen spurt and laser pulse timing. We present a finite difference thermal model along with data from tissue phantoms showing the effectiveness of the photoacoustic method.
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Nadkarni, Seemantini K. "Laser Speckle Rheology and Micromechanics." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2017. http://dx.doi.org/10.1364/omp.2017.omm4d.1.

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Bavali, A., P. Parvin, and R. Karimi. "Blue Spectral Shift of Laser-Induced Fluorescence Due to Suspension of Nano-structures in Rd6G Solution." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/omp.2015.om4d.2.

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Kolonics, Attila, Zsolt Csicsovszki, Orsolya Lorincz, Eniko Toke, Patrizia Stoitzner, Nikolaus Romani, Bernard Malissen, Julianna Lisziewicz, and Robert Szipocs. "Characterization of Nanoparticle Uptake by Epidermal Langerhans Cells in eGFP-Langerin Knock-in Mice by Multiphoton Laser Scanning Microscopy in vivo." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/omp.2013.mth1c.4.

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Agwu, Nnaoma, Kyle Deprow, John E. Williams, Jenna L. Gorlewicz, and Eric C. Leuthardt. "A Curved Port Delivery System for Laser Interstitial Thermal Therapy of Brain Tumors." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3305.

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Laser interstitial thermal therapy (LITT) is a neurosurgical procedure that involves using heat treatment to ablate glioblastomas in the brain. Current methods for placing probes in LITT involve straight trajectory pathways. This limitation often requires surgeons to make multiple trajectories or leave undesired margins. There has been extensive work in steerable needles, concentric tube cannulas, and flexible surgical tools. In this work, we present an approach which focuses on providing steerability to tools that aren’t inherently steerable. To do this, we developed a curved port delivery system that leverages an active cannula for the deployment of a plastic, flexible port that delivers existing surgical tools. We present an initial prototype coupled with feasibility results illustrating that the port can be placed to steer probes to a desired location.
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Raje, Shreya, Amir Sajjadi, Kunal Mitra, and Michael S. Grace. "Ablation of Subsurface Tumors Using 1552 nm Ultra-Short Pulse Laser." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192415.

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Over last two decades lasers have been used for the treatment of subsurface tumors. Various techniques such as Laser-induced Hyperthermia, Laser Interstitial Thermal Therapy (LITT), and Laser Immunotherapy have been developed for the successful ablation of subsurface tumors by different researchers. All these techniques use photo-thermal mechanism for tumor ablation by delivering thermal energy at the tumor site. In all these existing techniques, either continuous wave (CW) or long pulse laser source has been used, which often produces larger heat affected zone as compared to that produced by short pulse laser. Moreover, the delivery of laser beam at the target site is achieved through fiber optic probes which often require perforation of the skin. These drawbacks can be eliminated if a converging laser beam from a short pulse laser source is directly focused at the subsurface location to ablate the tumor.
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Viator, John A., and Steven L. Jacques. "Limitations of Photoacoustic Measurement of Burn Depth." In ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems. ASMEDC, 2005. http://dx.doi.org/10.1115/ht2005-72354.

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Noninvasive burn depth measurements would allow clinicians to manage burn injury better and improve treatment outcomes. Additionally, knowledge of the burn depth would allow surgeons to excise thermally damaged tissue without harming the underlying healthy tissue which is the source of epithelial cells important for proper healing response. We propose a photoacoustic method for inducing acoustic waves in burns. We used an Nd:YAG laser coupled to an optical fiber probe to deliver laser light to burn injury. Subsequent acoustic wave analysis results in burn depth profiling. We test ex vivo pig skin and optical diffusion theory to extrapolate these measurements to determine the maximum depth determined by this probe. We found that our probe can determine burn depths up to 2.8 mm. We propose changes to extend this depth to about 5 mm, the full thickness of human skin.
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Bhatnagar, Lakshya, and Guillermo Paniagua. "Development of High Speed and High Temperature Atomic Layer Thermopiles." In ASME Turbo Expo 2019: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/gt2019-91012.

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Abstract This work aims to provide a technique with which high frequency heat flux measurement data can be acquired in systems with high operational temperatures and high-speed flows with quantifiable and accurate uncertainty estimates. This manuscript presents the detailed calibration and application of an atomic layer thermopile, for heat fluxes with a frequency bandwidth of 0 to 1MHz. Two calibration procedures with a detailed uncertainty analysis. The first procedure consists using a laser to deliver radiation heat flux, while the second consists of a convective heat blowdown experiment. The use of this probe is demonstrated in a high-speed environment at Mach 2. The sensor effectively captures the passage of the normal shock wave and the values are compared with those computed using surface temperature measurement. Finally, a numerical study is carried out to design a cooling system that will allow the sensor to survive in high temperature conditions of 1273K while the sensor film is maintained at 323K. A two-dimensional axisymmetric conjugate heat transfer analysis is carried out to obtain the desired geometry.
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