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Journal articles on the topic 'Laser-driven Boron Neutron capture'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Edgecock, Rob. "Accelerator-driven boron neutron capture therapy." International Journal of Modern Physics A 29, no. 14 (2014): 1441004. http://dx.doi.org/10.1142/s0217751x14410048.

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Boron Neutron Capture Therapy is a binary treatment for certain types of cancer. It works by loading the cancerous cells with a boron-10 carrying compound. This isotope has a large cross-section for thermal neutrons, the reaction producing a lithium nucleus and alpha particle that kill the cell in which they are produced. Recent studies of the boron carrier compound indicate that the uptake process works best in particularly aggressive cancers. Most studied is glioblastoma multiforme and a trial using a combination of BNCT and X-ray radiotherapy has shown an increase of nearly a factor of two

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2

Hideghéty, Katalin, Rita Emilia Szabó, Róbert Polanek, Zoltán Szabó, Szilvia Brunner, and Tünde Tőkés. "New approaches in clinical application of laser-driven ionizing radiation." Proc. SPIE 10239, Medical Applications of Laser-Generated Beams of Particles IV: Review of Progress and Strategies for the Future 10239 (May 16, 2017): 102390A. https://doi.org/10.1117/12.2268300.

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The planned laser-driven ionizing beams (photon, very high energy electron, proton, carbon ion) at laser facilities have the unique property of ultra-high dose rate (>Gy/s^-10), short pulses, and at ELI-ALPS high repetition rate, carry the potential to develop novel laser-driven methods towards compact hospital-based clinical application. The enhanced flexibility in particle and energy selection, the high spatial and time resolution and extreme dose rate could be highly beneficial in radiotherapy. These approaches may increase significantly the therapeutic index over the currently available

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3

Zavestovskaya, Irina N., Anna I. Kasatova, Dmitry A. Kasatov, et al. "Laser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy." International Journal of Molecular Sciences 24, no. 23 (2023): 17088. http://dx.doi.org/10.3390/ijms242317088.

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Boron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by the employment of boron-containing nanoformulations, but the fabrication of biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore the use of elemental boron (B) NPs (BNPs) fabricated using the methods of pulsed laser ablation in liquids as sensitizers of BNCT. Depending on the conditions of laser-ablative synthesis, the used NPs were

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4

Zaboronok, Alexander, Polina Khaptakhanova, Sergey Uspenskii, et al. "Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments." Pharmaceutics 14, no. 4 (2022): 761. http://dx.doi.org/10.3390/pharmaceutics14040761.

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Sufficient boron-10 isotope (10B) accumulation by tumor cells is one of the main requirements for successful boron neutron capture therapy (BNCT). The inability of the clinically registered 10B-containing borophenylalanine (BPA) to maintain a high boron tumor concentration during neutron irradiation after a single injection has been partially solved by its continuous infusion; however, its lack of persistence has driven the development of new compounds that overcome the imperfections of BPA. We propose using elemental boron nanoparticles (eBNPs) synthesized by cascade ultrasonic dispersion and

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5

Chakrabarti, Amartya, and Narayan S. Hosmane. "Nanotechnology-driven chemistry of boron materials." Pure and Applied Chemistry 84, no. 11 (2012): 2299–308. http://dx.doi.org/10.1351/pac-con-12-01-05.

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The chemistry and reactivity of carborane-appended magnetic nanoparticles and boron-based nanomaterials are briefly reviewed with an emphasis on our contribution to this field. The carborane-appended magnetic nanoparticles exhibited great potential to be useful in boron neutron capture therapy (BNCT). A facile route to synthesize boron nanorods (BNRs) and boron nitride nanotubes (BNNTs) is also demonstrated. While functionalized BNRs and BNNTs have been successfully prepared, the derivatives of BNNTs were investigated as potential carriers for BNCT.

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6

Aiyyzhy, Kuder O., Ekaterina V. Barmina, Irina N. Zavestovskaya, et al. "Laser ablation of Fe₂B target enriched in ¹⁰B content for boron neutron capture therapy." Laser Physics Letters 19, no. 6 (2022): 066002. http://dx.doi.org/10.1088/1612-202x/ac642c.

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Abstract The technique of laser ablation in liquids is applied to produce Boron-containing nanoparticles from ablation of a Fe2B bulk target enriched in 10B isotope. Laser ablation of the target in liquid isopropanol results in partial disproportionation to free Fe and Boron while nanoparticles of Fe2B are also presented. The nanoparticles are magnetic and can be collected using a permanent magnet. The average size of nanoparticles is about 15 nm. The content of 10B in the generated nanoparticles amounts to 76.9%. The nanoparticles are biocompatible and can be used in boron neutron capture the

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7

Haselsberger, Klaus, Herbert Radner, Walter Gössler, Claudia Schlagenhaufen, and Gerhard Pendl. "Subcellular boron-10 localization in glioblastoma for boron neutron capture therapy with Na2B12H11SH." Journal of Neurosurgery 81, no. 5 (1994): 741–44. http://dx.doi.org/10.3171/jns.1994.81.5.0741.

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✓ Because of the short range of the highly energetic particles helium-4 and lithium-7 that results from neutron-induced disintegration of boron-10, the efficacy of Boron Neutron Capture Therapy (BNCT) is heavily dependent on 10B-microlocation. Despite the crucial importance of boron-10, there is little specific information with regard to the agent currently used for inducing BNCT, namely Na2B12H11SH. In the present study, a subcellular 10B-location was investigated in tumor tissue obtained from seven patients with glioblastoma World Health Organization Grade IV. These patients received Na2B12H

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8

Yinghuai, Zhu, Koh Cheng Yan, John A. Maguire, and Narayan S. Hosmane. "Recent Developments in Boron Neutron Capture Therapy (BNCT) Driven by Nanotechnology." Current Chemical Biology 1, no. 2 (2007): 141–49. http://dx.doi.org/10.2174/187231307780636431.

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9

Yinghuai, Zhu, Koh Cheng Yan, John Maguire, and Narayan Hosmane. "Recent Developments in Boron Neutron Capture Therapy (BNCT) Driven by Nanotechnology." Current Chemical Biology 1, no. 2 (2007): 141–49. http://dx.doi.org/10.2174/2212796810701020141.

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10

Skalyga, V., I. Izotov, S. Golubev, et al. "Gyrotron-driven high current ECR ion source for boron-neutron capture therapy neutron generator." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 768 (December 2014): 146–50. http://dx.doi.org/10.1016/j.nima.2014.09.058.

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11

Zhang, Zizhu, Yizheng Chong, Yuanhao Liu, et al. "A Review of Planned, Ongoing Clinical Studies and Recent Development of BNCT in Mainland of China." Cancers 15, no. 16 (2023): 4060. http://dx.doi.org/10.3390/cancers15164060.

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Boron neutron capture therapy (BNCT) is a promising cancer treatment modality that combines targeted boron agents and neutron irradiation to selectively destroy tumor cells. In mainland China, the clinical implementation of BNCT has made certain progress, primarily driven by the development of compact neutron source devices. The availability, ease of operation, and cost-effectiveness offered by these compact neutron sources make BNCT more accessible to cancer treatment centers. Two compact neutron sources, one being miniature reactor-based (IHNI-1) and the other one being accelerator-based (Ne

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12

Lai, Yuxuan, and Yigang Yang. "A Design for the High Yield Photoneutron Source Target Station." Materials 15, no. 21 (2022): 7674. http://dx.doi.org/10.3390/ma15217674.

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Low energy accelerator driven neutron sources are promising candidates to obtain a neutron yield as high as 1014 n/s, which is required for a variety of applications, such as boron neutron capture therapy, neutron imaging, and neutron scattering. The methods to generate neutrons can be divided into two categories: hadron-based and photon-based methods. In order to better understand which kind of source would be the better choice for delivering a brilliant neutron beam robustly, in this paper, the underlying principles of neutron production, as well as the simulation results of neutron yield, t

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13

Powell, James R., Hans Ludewig, Michael Todosow, and Morris Reich. "Target and Filter Concepts for Accelerator-Driven Boron Neutron Capture Therapy Applications." Nuclear Technology 125, no. 1 (1999): 104–15. http://dx.doi.org/10.13182/nt99-a2936.

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14

Nishitani, Takeo, Sachiko Yoshihashi, Yuuki Tanagami, et al. "Neutronics Analyses of the Radiation Field at the Accelerator-Based Neutron Source of Nagoya University for the BNCT Study." Journal of Nuclear Engineering 3, no. 3 (2022): 222–32. http://dx.doi.org/10.3390/jne3030012.

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The Nagoya University Accelerator-driven Neutron Source (NUANS) is an accelerator-based neutron source by 7Li(p,n)7Be reaction with a 2.8 MeV proton beam up to 15 mA. The fast neutrons are moderated and shaped to beam with a Beam Shaping Assembly (BSA). NUANS is aiming at the basic study of the Boron Neutron Capture Therapy (BNCT) such as an in vitro cell-based irradiation experiment using a water phantom. Moreover, the BSA is developed as a prototype of one for human treatment. We have evaluated the radiation field of NUANS by a Monte Carlo code PHITS. It is confirmed that the radiation chara

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15

Kalot, Ghadir, Amélie Godard, Benoît Busser, et al. "Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications." Cells 9, no. 9 (2020): 1953. http://dx.doi.org/10.3390/cells9091953.

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Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on the nuclear capture of slow neutrons by stable 10B atoms followed by charged particle emission that inducing extensive damage on a very localized level (<10 μm). To be efficient, a sufficient amount of 10B should accumulate in the tumor area while being almost cleared from the normal surroundings. A water-soluble aza-boron-dipyrromethene dyes (BODIPY) fluorophore was reported to strongly accumulate in the tumor area with high and BNCT compatible Tumor/Healthy Tissue ratios. The clinically used 10B-BSH (sodium boroc

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16

Kasatova, A. I., K. S. Kuzmina, D. A. Kasatov, et al. "Elemental Boron-10 Nanoparticles Synthesized by Laser Fragmentation for Boron Neutron Capture Therapy: In Vitro Experiments." Bulletin of the Lebedev Physics Institute 52, no. 2 (2025): 95–102. https://doi.org/10.3103/s1068335624602541.

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17

Watanabe, Kenichi, Sachiko Yoshihashi, Akihisa Ishikawa, et al. "First experimental verification of the neutron field of Nagoya University Accelerator-driven neutron source for boron neutron capture therapy." Applied Radiation and Isotopes 168 (February 2021): 109553. http://dx.doi.org/10.1016/j.apradiso.2020.109553.

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18

Ganda, Francesco, Jasmina Vujic, Ehud Greenspan, and Ka-Ngo Leung. "Compact D-D Neutron Source-Driven Subcritical Multiplier and Beam-Shaping Assembly for Boron Neutron Capture Therapy." Nuclear Technology 172, no. 3 (2010): 302–24. http://dx.doi.org/10.13182/nt10-a10939.

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19

Angelone, M., S. Atzeni, and S. Rollet. "Conceptual study of a compact accelerator-driven neutron source for radioisotope production, boron neutron capture therapy and fast neutron therapy." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 487, no. 3 (2002): 585–94. http://dx.doi.org/10.1016/s0168-9002(02)00399-6.

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20

Kusaka, Sachie, Yumi Miyake, Yugo Tokumaru, et al. "Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging." Life 12, no. 11 (2022): 1786. http://dx.doi.org/10.3390/life12111786.

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The blood–brain barrier (BBB) is likely to be intact during the early stages of brain metastatic melanoma development, and thereby inhibits sufficient drug delivery into the metastatic lesions. Our laboratory has been developing a system for boron drug delivery to brain cells via cerebrospinal fluid (CSF) as a viable pathway to circumvent the BBB in boron neutron capture therapy (BNCT). BNCT is a cell-selective cancer treatment based on the use of boron-containing drugs and neutron irradiation. Selective tumor targeting by boron with minimal normal tissue toxicity is required for effective BNC

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21

Hiraga, F. "Monte Carlo simulation-based design for an electron-linear-accelerator-driven subcritical neutron multiplier for boron neutron capture therapy." Applied Radiation and Isotopes 140 (October 2018): 121–25. http://dx.doi.org/10.1016/j.apradiso.2018.06.023.

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22

Kurihara, Toshikazu, and Hitoshi Kobayashi. "Diffusion bonded Be neutron target using 8MeV proton beam." EPJ Web of Conferences 231 (2020): 03001. http://dx.doi.org/10.1051/epjconf/202023103001.

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The development of the high intensity compact neutron source is mainly conducted by using accelerators for medical purposes. Recently, a lot of compact neutron sources have been developed, and most of them are for boron neutron capture therapy (BNCT). Compared with the common accelerators used for industries, accelerators for BNCT have to accelerate a 100 times larger current of charged particles because of the low conversion efficiency of neutron moderators. To attain a reliable target for the BNCT neutron source, two obstacles have to be overcome; radiation damage (blistering) and heat issue

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23

Hiraga, F. "Optimum design and criticality safety of a beam-shaping assembly with an accelerator-driven subcritical neutron multiplier for boron neutron capture therapies." Applied Radiation and Isotopes 106 (December 2015): 84–87. http://dx.doi.org/10.1016/j.apradiso.2015.07.029.

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24

Inoue, R., F. Hiraga, and Y. Kiyanagi. "Optimum design of a moderator system based on dose calculation for an accelerator driven Boron Neutron Capture Therapy." Applied Radiation and Isotopes 88 (June 2014): 225–28. http://dx.doi.org/10.1016/j.apradiso.2013.12.017.

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25

Cerullo, N., J. Esposito, and K. N. Leung. "Irradiation facility for boron neutron capture therapy application based on a rf-driven D–T neutron source and a new beam shaping assembly (abstract)." Review of Scientific Instruments 73, no. 2 (2002): 938. http://dx.doi.org/10.1063/1.1433920.

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26

Raskolupova, Valeria I., Tatyana V. Popova, Olga D. Zakharova, Anastasia E. Nikotina, Tatyana V. Abramova, and Vladimir N. Silnikov. "Human Serum Albumin Labelling with a New BODIPY Dye Having a Large Stokes Shift." Molecules 26, no. 9 (2021): 2679. http://dx.doi.org/10.3390/molecules26092679.

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BODIPY dyes are photostable neutral derivatives of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene. These are widely used as chemosensors, laser materials, and molecular probes. At the same time, BODIPY dyes have small or moderate Stokes shifts like most other fluorophores. Large Stokes shifts are preferred for fluorophores because of higher sensitivity of such probes and sensors. The new boron containing BODIPY dye was designed and synthesized. We succeeded to perform an annulation of pyrrole ring with coumarin heterocyclic system and achieved a remarkable difference in absorption and emission max

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27

Cerullo, Nicola, Juan Esposito, Ka Ngo Leung, and Salvatore Custodero. "An irradiation facility for Boron Neutron Capture Therapy application based on a radio frequency driven D–T neutron source and a new beam shaping assembly." Review of Scientific Instruments 73, no. 10 (2002): 3614–18. http://dx.doi.org/10.1063/1.1505128.

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28

Zavestovskaya, Irina N., Anton L. Popov, Danil D. Kolmanovich, et al. "Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment." Nanomaterials 13, no. 15 (2023): 2167. http://dx.doi.org/10.3390/nano13152167.

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Proton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized B NPs were efficiently absorbed by MNNG/Hos human o

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29

Raskolupova, Valeria I., Tatyana V. Popova, Olga D. Zakharova, Tatyana V. Abramova, and Vladimir N. Silnikov. "New BODIPY Dye with a Large Stokes Shift for Biopolymer Labelling." Chemistry Proceedings 3, no. 1 (2020): 72. http://dx.doi.org/10.3390/ecsoc-24-08304.

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As the most abundant protein with a variety of physiological functions, human serum albumin (HSA) has been used extensively for the delivery and improvement of therapeutic molecules. Thiolactone chemistry provides a powerful tool to prepare albumin-based multimodal imaging probes and agents for boron neutron capture therapy (BNCT). For this purpose, boron containing 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye was designed and synthesized. BODIPY dyes are photostable neutral derivatives of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene. These are widely used as chemosensors, laser mater

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30

Hashimoto, Y., F. Hiraga, and Y. Kiyanagi. "Optimal moderator materials at various proton energies considering photon dose rate after irradiation for an accelerator-driven 9Be(p, n) boron neutron capture therapy neutron source." Applied Radiation and Isotopes 106 (December 2015): 88–91. http://dx.doi.org/10.1016/j.apradiso.2015.07.027.

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31

Webster, Matthew, Alexander Podgorsak, Fiona Li, et al. "New Approaches in Radiotherapy." Cancers 17, no. 12 (2025): 1980. https://doi.org/10.3390/cancers17121980.

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Radiotherapy (RT) has undergone transformative advancements since its inception over a century ago. This review highlights the most promising and impactful innovations shaping the current and future landscape of RT. Key technological advances include adaptive radiotherapy (ART), which tailors treatment to daily anatomical changes using integrated imaging and artificial intelligence (AI), and advanced image guidance systems, such as MR-LINACs, PET-LINACs, and surface-guided radiotherapy (SGRT), which enhance targeting precision and minimize collateral damage. AI and data science further support

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32

Morris, Austin, Jianfeng Lv, and Yuanrong Lu. "LASER-DRIVEN LITHIUM NEUTRON CAPTURE THERAPY." International Journal of Particle Therapy 12 (June 2024): 100522. http://dx.doi.org/10.1016/j.ijpt.2024.100522.

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33

Schollmeier, Marius S., Vahe Shirvanyan, Christie Capper, et al. "Investigation of Proton Beam-Driven Fusion Reactions Generated by an Ultra-Short Petawatt-Scale Laser Pulse." Laser and Particle Beams 2022 (October 13, 2022): 1–13. http://dx.doi.org/10.1155/2022/2404263.

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We present results from a pitcher-catcher experiment utilizing a proton beam generated with nanostructured targets at a petawatt-class, short-pulse laser facility to induce proton-boron fusion reactions in a secondary target. A 45-fs laser pulse with either 400 nm wavelength and 7 J energy, or 800 nm and 14 J, and an intensity of up to 5 × 1021 W/cm2 was used to irradiate either thin foil targets or near-solid density, nanostructured targets made of boron nitride (BN) nanotubes. In particular, for 800 nm wavelength irradiation, a BN nanotube target created a proton beam with about five times h

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34

Hora, H., G. H. Miley, N. Azizi, B. Malekynia, M. Ghoranneviss, and X. T. He. "Nonlinear force driven plasma blocks igniting solid density hydrogen boron: Laser fusion energy without radioactivity." Laser and Particle Beams 27, no. 3 (2009): 491–96. http://dx.doi.org/10.1017/s026303460999022x.

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AbstractEnergy production by laser driven fusion energy is highly matured by spherical compression and ignition of deuterium-tritium (DT) fuel. An alternative scheme is the fast ignition where petawatt (PW)-picosecond (ps) laser pulses are used. A significant anomaly was measured and theoretically analyzed with very clean PW-ps laser pulses for avoiding relativistic self focusing. This permits a come-back of the side-on ignition scheme of uncompressed solid DT, which is in essential contrast to the spherical compression scheme. The conditions of side-on ignition thresholds needed exorbitantly

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35

Hegelich, B. M., L. Labun, O. Z. Labun, and T. A. Mehlhorn. "Photon and Neutron Production as In Situ Diagnostics of Proton-Boron Fusion." Laser and Particle Beams 2023 (May 8, 2023): 1–14. http://dx.doi.org/10.1155/2023/6924841.

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Short-pulse, ultrahigh-intensity lasers have opened new regimes for studying fusion plasmas and creating novel ultrashort ion beams and neutron sources. Diagnosing the plasma in these experiments is important for optimizing the fusion yield but difficult due to the picosecond time scales, 10 s of micron-cubed volumes, and high densities. We propose to use the yields of photons and neutrons produced by parallel reactions involving the same reactants to diagnose the plasma conditions and predict the yields of specific reactions of interest. In this work, we focus on verifying the yield of the hi

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36

Pastukhov, Andrei I., Iaroslav B. Belyaev, Julia C. Bulmahn, et al. "Laser-ablative aqueous synthesis and characterization of elemental boron nanoparticles for biomedical applications." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-13066-8.

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AbstractBoron-based nano-formulations look very promising for biomedical applications, including photo- and boron neutron capture therapies, but the fabrication of non-toxic water-dispersible boron nanoparticles (NPs), which contain the highest boron atom concentration, is difficult using currently available chemical and plasma synthesis methods. Here, we demonstrate purely aqueous synthesis of clean boron NPs by methods of femtosecond laser ablation from a solid boron target in water, thus free of any toxic organic solvents, and characterize their properties. We show that despite highly oxidi

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37

Kiyanagi, Yoshiaki. "Neutron applications developing at compact accelerator-driven neutron sources." AAPPS Bulletin 31, no. 1 (2021). http://dx.doi.org/10.1007/s43673-021-00022-3.

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AbstractNeutrons have been used in a wide field of applications by using various neutron sources. Material science is one of the widest research fields. The activity is supported by nuclear research reactors and high-intensity spallation neutron sources based on a high-intensity proton accelerator. However, it is desired to perform a measurement when researchers want to do and to perform adventuresome experiments that have not yet confirmed its importance. Furthermore, trial and error measurements are necessary to improve a measurement method. Compact accelerator-driven neutron sources are sui

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Tani, Toshiaki, Tomoya Fujita, Masaki Misawa, et al. "Advanced Boron Neutron Capture Therapy Targeting Cancer Stem Cells by Selective Induction of LAT1 Overexpression." Radiation Research, May 22, 2023. http://dx.doi.org/10.1667/rade-22-00195.1.

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This study conducted fundamental research to develop a more effective BNCT targeting cancer stem cells. We constructed plasmids that induced the overexpression of L-type amino acid transporter 1 (LAT1) tagged with tdTomato on the cytoplasmic membranes of CD133 expressing cancer cells. After transfection of the plasmids into a glioblastoma cell line (T98G), several clones overexpressing LAT1-tdTomato in the hypoxic microenvironment of the spheroids formed from each clone were obtained. Confocal laser microscopic observation confirmed that signals from LAT1-tdTomato overlapped with immunofluores

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39

Iwasaki, Ryota, Ryutaro Yoshikawa, Ryo Umeno, et al. "The effects of BPA-BNCT on normal bone: determination of the CBE value in mice." Journal of Radiation Research, July 29, 2023. http://dx.doi.org/10.1093/jrr/rrad054.

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Abstract Boron neutron capture therapy (BNCT) with p-boronophenylalanine (BPA) is expected to have less effect on the decrease in normal bone strength than X-ray therapy. However, the compound biological effectiveness (CBE) value necessary to convert the boron neutron capture reaction (BNCR) dose into a bioequivalent X-ray dose has not been determined yet. The purpose of this study was to evaluate the influence of BNCT on normal bone in mice and to elucidate the CBE factor. We first searched the distribution of BPA in the normal bone of C3H/He mice and then measured the changes in bone strengt

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40

Hu, Yaocheng, Xiaobo Li, Yongsheng Lv, et al. "Simulations on the thermal and mechanical performance of the rotating target system of accelerator-driven neutron source for Boron Neutron Capture Therapy(BNCT)." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, May 2023, 168340. http://dx.doi.org/10.1016/j.nima.2023.168340.

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41

Scaramuzza, Stefano, Clara M. G. de Faria, Vito Coviello, et al. "A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging." Advanced Functional Materials, June 20, 2023. http://dx.doi.org/10.1002/adfm.202303366.

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42

Honda, Shogo, Sachiko Yoshihashi, Yukinori Hamaji, et al. "Evaluation of heat removal performance of a sealed Li target for an accelerator-driven neutron source of Boron Neutron Capture Therapy at Nagoya University." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, August 2022, 167414. http://dx.doi.org/10.1016/j.nima.2022.167414.

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43

Miyake, Yumi, Sachie Kusaka, Isao Murata, and Michisato Toyoda. "Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging of L-4-Phenylalanineboronic Acid (BPA) in a Brain Tumor Model Rat for Boron Neutron Capture Therapy (BNCT)." Mass Spectrometry, 2022. http://dx.doi.org/10.5702/massspectrometry.a0105.

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44

Neudecker, D., T. E. Cutler, M. Devlin, et al. "Machine Learning to Select Experiments Driven by Fundamental Science and Applications for Targeted Nuclear Data Improvement." Physical Review X 15, no. 2 (2025). https://doi.org/10.1103/physrevx.15.021086.

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This work describes a blueprint for a process that accelerates progress in science by quantitatively answering the following question: What is the optimal combination of fundamental-science and application-driven experiments to maximally reduce pertinent data uncertainties? Answering this question entails solving a high-dimensional and complex optimization problem that is best solved with advanced statistic techniques often classified as machine learning. We apply this process within the framework of nuclear data with the aim to select an experiment combination that will reduce uncertainties i

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Dosanjh, Manjit, Alberto Degiovanni, Maria Monica Necchi, and Elena Benedetto. "Multidisciplinary Collaboration and Novel Technological Advances in Hadron Therapy." Technology in Cancer Research & Treatment 24 (January 2025). https://doi.org/10.1177/15330338241311859.

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The battle against cancer remains a top priority for society, with an urgent need to develop therapies capable of targeting challenging tumours while preserving patient's quality of life. Hadron Therapy (HT), which employs accelerated beams of protons, carbon ions, and other charged particles, represents a significant frontier in cancer treatment. This modality offers superior precision and efficacy compared to conventional methods, delivering therapeutic the dose directly to tumours while sparing healthy tissue. Even though 350,000 patients have already been treated worldwide with protons and

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Morris, Austin A., Jianfeng Lv, and Yuanrong Lu. "Advancing lithium neutron capture therapy: 6Li-loaded nanoparticles and laser-driven neutron sources." Applied Physics Letters 124, no. 4 (2024). http://dx.doi.org/10.1063/5.0185189.

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We report on 6Li neutron capture therapy (LiNCT) in anticipation of using carbon nanoparticles to deliver targeted, high linear energy transfer radiation to non-resectable tumors. Our investigations show that, compared with existing 10B neutron capture therapy (BNCT), 6Li offers similar dose potential for equal mass density (DLi∼DB when mLi=mB), for capture products that span 7 times more range and approximately three cell lengths. Consequently, 6Li-filled nanoparticles dispersed more than half-a-cell-length apart, better convey high doses and ultra-high dose-rates, as LiNCT generates substant

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Hill, Paul, and Yuanbin Wu. "Exploring laser-driven neutron sources for neutron capture cascades and the production of neutron-rich isotopes." Physical Review C 103, no. 1 (2021). http://dx.doi.org/10.1103/physrevc.103.014602.

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Jiao, X., C. B. Curry, M. Gauthier, et al. "High deuteron and neutron yields from the interaction of a petawatt laser with a cryogenic deuterium jet." Frontiers in Physics 10 (January 9, 2023). http://dx.doi.org/10.3389/fphy.2022.964696.

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A compact high-flux, short-pulse neutron source would have applications from nuclear astrophysics to cancer therapy. Laser-driven neutron sources can achieve fluxes much higher than spallation and reactor neutron sources by reducing the volume and time in which the neutron-producing reactions occur by orders of magnitude. We report progress towards an efficient laser-driven neutron source in experiments with a cryogenic deuterium jet on the Texas Petawatt laser. Neutrons were produced both by laser-accelerated multi-MeV deuterons colliding with Be and mixed metallic catchers and by d (d,n)3He

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Tosca, Marco, Daniel Molloy, Aaron McNamee, et al. "Plasma polymers as targets for laser-driven proton-boron fusion." Frontiers in Physics 11 (July 27, 2023). http://dx.doi.org/10.3389/fphy.2023.1227140.

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Laser-driven proton-boron (pB) fusion has been gaining significant interest for energetic alpha particles production because of its neutron-less nature. This approach requires the use of B- and H-rich materials as targets, and common practice is the use of BN and conventional polymers. In this work, we chose plasma-assisted vapour phase deposition to prepare films of oligoethylenes (plasma polymers) on Boron Nitride BN substrates as an advanced alternative. The r.f. power delivered to the plasma was varied between 0 and 50 W to produce coatings with different crosslink density and hydrogen con

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Vundru, Chaitanya, Ramesh Singh, Wenyi Yan, and Shyamprasad Karagadde. "The Effect of Martensitic Transformation on the Evolution of Residual Stresses and Identification of the Critical Linear Mass Density in Direct Laser Metal Deposition–Based Repair." Journal of Manufacturing Science and Engineering 142, no. 7 (2020). http://dx.doi.org/10.1115/1.4046828.

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Abstract Direct laser metal deposition (DLMD) is a promising additive manufacturing technique which has a huge potential in remanufacturing and restoration of high-value dies/molds and aerospace components. The residual stresses developed in the material deposited via DLMD affect the structural integrity of the restored components. The service life of the restored component will be compromised if tensile residual stresses are present in the deposited layer. The residual stresses originate due to differential thermal expansion/contraction and martensitic transformation-driven volumetric dilatio

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