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Journal articles on the topic 'LASI-DAD'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Lee, Jinkook. "Late-Life Cognition and Dementia in India: New Insights From LASI-DAD." Innovation in Aging 4, Supplement_1 (2020): 659. http://dx.doi.org/10.1093/geroni/igaa057.2277.

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Abstract With more than1.35 billion people, India, the second-most populous country in the world, is soon to experience rapid aging of its population. By2050, India’s older population is projected to reach320 million (about the current size of the entire U.S. population). In this session we introduce the Longitudinal Aging Study in India – Diagnostic Assessment of Dementia (LASI-DAD), a new cohort study designed to advance dementia research to better understand late-life cognition, cognitive aging, cognitive impairment, and dementia, as well as their risk and protective factors. LASI is a pros

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Lee, Jinkook, Pranali Khobragade, Joyita Banerjee, and Sandy Chien. "Design and Methodology of the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia." Innovation in Aging 4, Supplement_1 (2020): 660. http://dx.doi.org/10.1093/geroni/igaa057.2279.

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Abstract Longitudinal Aging Study in India is a nationally representative survey of the health, economic, and social wellbeing of the Indian population aged 45 and older. LASI-DAD is an in-depth study of late-life cognition and dementia, drawing a sub-sample of over 4,000 LASI respondents aged 60 or older. Respondents underwent a battery of cognitive tests, while their informants were interviewed about their cognitive and health conditions. A common set of cognitive tests was selected to enable international comparisons, and additional cognitive tests suitable for illiterate and innumerate pop

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Gross, Alden, Pranali Khobragade, Erik Meijer, and Judith Saxton. "Measurement and Structure of Cognition in the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia." Innovation in Aging 4, Supplement_1 (2020): 660. http://dx.doi.org/10.1093/geroni/igaa057.2280.

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Abstract We tested whether a complex model of human cognitive abilities based on Cattell-Horn-Carroll (CHC) theory, developed in English-speaking samples, adequately describes correlations among tests in the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) (N=3,224). Tests in the neuropsychological battery were chosen for their appropriateness for measuring cognition in older adults in India and suitability for co-calibration with the core LASI survey (N=72,000). We evaluated the factor structure and its conformity with a classical CHC factor model incorporating m

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Jin, Haomiao, Sandy Chien, Erik Meijer, Pranali Khobragade, and Jinkook Lee. "Learning From Clinical Consensus Diagnosis in India to Facilitate Automatic Classification of Dementia: Machine Learning Study." JMIR Mental Health 8, no. 5 (2021): e27113. http://dx.doi.org/10.2196/27113.

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Background The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative study on late-life cognition and dementia in India (n=4096). LASI-DAD obtained clinical consensus diagnosis of dementia for a subsample of 2528 respondents. Objective This study develops a machine learning model that uses data from the clinical consensus diagnosis in LASI-DAD to support the classification of dementia status. Methods Clinicians were presented with the extensive data collected from LASI-DAD, including sociodemographic in

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Lee, Jinkook, Joyita Banerjee, Pranali Yogiraj Khobragade, Marco Angrisani, and A. B. Dey. "LASI-DAD study: a protocol for a prospective cohort study of late-life cognition and dementia in India." BMJ Open 9, no. 7 (2019): e030300. http://dx.doi.org/10.1136/bmjopen-2019-030300.

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IntroductionAlzheimer’s disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burden of dementia presents an urgent challenge for India, previous efforts to study dementia in the country have relied on non-representative samples in geographically restricted regions. The Harmonised Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-

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Dhankhar, Anushikha, Pranali Khobragade, Joyita Banerjee, et al. "Methodology of community-based venous blood specimen collection for the harmonized diagnostic assessment of dementia for the Longitudinal Aging Study in India (LASI-DAD): Wave 2." PLOS One 20, no. 7 (2025): e0326917. https://doi.org/10.1371/journal.pone.0326917.

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The prevalence of dementia is on the rise, with 60% of dementia cases existing in low- and middle-income countries. In India, the prevalence was reported to be 7.4%. Since the pathophysiology of dementia is multifactorial, the Harmonized Longitudinal Aging Study in India for the Diagnostic Assessment of Dementia (LASI-DAD) collected data to capture multiple domains, including venous blood specimens (VBS). VBS collection and assays help ascertain the overall health status of an individual, understand disease pathogenesis, and diagnose diseases. In community settings, blood assays also help iden

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Vonk, Jet M. J., Alden L. Gross, Andrea R. Zammit, et al. "Cross-national harmonization of cognitive measures across HRS HCAP (USA) and LASI-DAD (India)." PLOS ONE 17, no. 2 (2022): e0264166. http://dx.doi.org/10.1371/journal.pone.0264166.

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Background As global populations age, cross-national comparisons of cognitive health and dementia risk are increasingly valuable. It remains unclear, however, whether country-level differences in cognitive function are attributable to population differences or bias due to incommensurate measurement. To demonstrate an effective method for cross-national comparison studies, we aimed to statistically harmonize measures of episodic memory and language function across two population-based cohorts of older adults in the United States (HRS HCAP) and India (LASI-DAD). Methods Data for 3,496 HRS HCAP (

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Jayakody, Oshadi, Helena Blumen, and Joe Verghese. "A CROSS-NATIONAL COMPARISON OF RISK FACTORS ASSOCIATED WITH THE MOTORIC COGNITIVE RISK (MCR) SYNDROME." Innovation in Aging 7, Supplement_1 (2023): 284. http://dx.doi.org/10.1093/geroni/igad104.0945.

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Abstract The Motoric Cognitive Risk (MCR) syndrome predicts risk of Alzheimer’s disease and vascular dementia. Cross-national comparisons of risk factors for MCR are important for identifying region-specific factors to design regionally tailored preventive interventions. We examined risk factors associated with MCR in 20,468 adults aged ≥65 years from the U.S Health and Retirement Study (HRS), English Longitudinal Study of Ageing (ELSA), Mexican Health and Aging Study (MHAS), China Health and Retirement Study (CHARLES), Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging St

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Abu-Amara, Hasan, Wei Zhao, Zheng Li, et al. "Region-Based Analysis with Functional Annotation Identifies Genes Associated with Cognitive Function in South Asians from India." Genes 16, no. 6 (2025): 640. https://doi.org/10.3390/genes16060640.

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Background/Objectives: The prevalence of dementia among South Asians across India is high among those who are 65 years and older, yet little is known about genetic risk factors for dementia in this population. Methods: Using whole-genome sequence data from 2680 participants from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD), we performed a gene-based analysis on the missense/loss-of-function (LoF) and brain-specific promoter/enhancer variants of 84 genes, previously associated with AD in European Ancestry (EA). These analyses were performed separate

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Pan, Xi, Uma Kelekar, and T. Muhammad. "THE RELATIONSHIP BETWEEN ORAL HEALTH AND COGNITIVE FUNCTION: EVIDENCE FROM THE LASI." Innovation in Aging 7, Supplement_1 (2023): 920. http://dx.doi.org/10.1093/geroni/igad104.2957.

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Abstract The present study aimed to examine the association between oral health and cognitive function among older adults in India. Data for the study were selected from the Longitudinal Aging Survey of India (LASI, 2017-2019) and the LASI Diagnostic Assessment of Dementia (LASI-DAD) and 4,096 respondents aged 60 and above were included. Oral health was measured by self-reported physician-diagnosed oral health problems including presence of painful teeth, ulcers for more than two weeks, bleeding gums, swelling gums, loose teeth, dental cavities or caries, soreness or cracks in the corners of t

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Gross, Alden L., Emma Nichols, Marco Angrisani, et al. "Prevalence of DSM-5 mild and major neurocognitive disorder in India: Results from the LASI-DAD." PLOS ONE 19, no. 2 (2024): e0297220. http://dx.doi.org/10.1371/journal.pone.0297220.

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Introduction India, with its rapidly aging population, faces an alarming burden of dementia. We implemented DSM-5 criteria in large-scale, nationally representative survey data in India to characterize the prevalence of mild and major Neurocognitive disorder. Methods The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) (N = 4,096) is a nationally representative cohort study in India using multistage area probability sampling methods. Using neuropsychological testing and informant reports, we defined DSM-5 mild and major neurocognitive disorder,

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Saritha, Ala, Rohit Jangra, Lekha Bhat, and Neena Elezebeth Philip. "Knowledge, attitude, and practice among the Indian population regarding COVID-19 using LASI-DAD COVID-19 data." International Journal of Public Health Science (IJPHS) 14, no. 2 (2025): 634. https://doi.org/10.11591/ijphs.v14i2.23836.

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During the COVID-19 pandemic, India was one of the worst-hit countries in terms of the number of cases and deaths. Knowledge, attitude, and practice play an important role in reducing disease transmission. This study uses a nationally represented large data set to understand the knowledge, attitude, and practice (KAP) of COVID-19 among the Indian population. This cross-sectional study utilized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) COVID-19 data which provides information on respondents’ demographics, socioeconomic effects, health status, behavio

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Lee, Jinkook, Marco Angrisani, and Urvashi Jain. "Gender Inequality and Late-Life Cognition." Innovation in Aging 4, Supplement_1 (2020): 659–60. http://dx.doi.org/10.1093/geroni/igaa057.2278.

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Abstract Indian women’s disadvantage in cognition has been documented in several studies, additionally noting geographic variations. The gender gap in late-life cognition could be a manifestation of gender discrimination. Using national data from LASI-DAD together with information drawn from administrative data, we construct a state-level composite index of gender inequality, following the UNDP definition. We investigate and find strong evidence that cross-state differences in gender inequality are significantly associated with the gender gap in cognition. Women in the most discriminating stat

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Ehrlich, Joshua, Sandy Chien, and Jinkook Lee. "Vision and Cognition: Findings from the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia." Innovation in Aging 4, Supplement_1 (2020): 660. http://dx.doi.org/10.1093/geroni/igaa057.2281.

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Abstract Vision impairment (VI) is associated with cognitive decline and dementia, however little research has been conducted in India. Using data from LASI-DAD, linear models tested the association of VI (better-seeing eye &lt;20/60) with cognitive domains including orientation, learning/memory, language, attention, and total cognition. Models were adjusted for age, sex, geographic, and socioeconomic characteristics. VI was significantly associated with lower orientation (β=-0.47, p&lt;.01), learning/memory (β=-4.6, p&lt;.01), attention (β=-1.6, p&lt;.01), and total cognition

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Banerjee, Joyita, Urvashi Jain, Pranali Khobragade, et al. "Methodological considerations in designing and implementing the harmonized diagnostic assessment of dementia for longitudinal aging study in India (LASI–DAD)." Biodemography and Social Biology 65, no. 3 (2019): 189–213. http://dx.doi.org/10.1080/19485565.2020.1730156.

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Bhagwasia, Manjusha, Abhijith Rajaram Rao, Joyita Banerjee, et al. "Defining anthropometric thresholds (mid-arm circumference and calf circumference) in older adults residing in the community: a cross-sectional analysis using data from the population representative Longitudinal Aging Study in India (LASI DAD)." BMJ Open 13, no. 12 (2023): e077530. http://dx.doi.org/10.1136/bmjopen-2023-077530.

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ObjectivesTo identify factors associated with malnutrition (undernutrition and overnutrition) and determine appropriate cut-off values for mid-arm circumference (MAC) and calf circumference (CC) among community-dwelling Indian older adults.DesignData from the first wave of harmonised diagnostic assessment of dementia for Longitudinal Ageing Study in India (LASI-DAD) were used. Various sociodemographic factors, comorbidities, geriatric syndromes, childhood financial and health status were included. Anthropometric measurements included body mass index (BMI), MAC and CC.SettingNationally represen

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Nichols, Emma, Michael Markot, Alden Gross, Richard Jones, Stefan Schneider, and Jinkook Lee. "ADDED VALUE OF TIMING DATA FOR THE ESTIMATION OF COGNITIVE FUNCTIONING IN SURVEY RESEARCH." Innovation in Aging 8, Supplement_1 (2024): 448. https://doi.org/10.1093/geroni/igae098.1457.

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Abstract The use of speeded tests to assess cognition supports the notion that response times on cognitive tests contain meaningful information about cognitive functioning. Although information on the time spent completing cognitive tests is often collected during survey administration, this data is not typically considered when quantifying cognitive functioning in large-scale surveys. We used data from the Longitudinal Aging Study in India – Diagnostic Assessment of Dementia (LASI-DAD) study (N=4,091), to assess the added value of data on the time spent on cognitive tests (items), over and ab

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Nichols, Emma, Yizhou Chen, Adina Zeki Al Hazzouri, et al. "VISION IMPAIRMENT AND COGNITION IN INDIA: ASSOCIATIONS AFTER ADJUSTMENT FOR POTENTIAL BIAS." Innovation in Aging 7, Supplement_1 (2023): 1156–57. http://dx.doi.org/10.1093/geroni/igad104.3711.

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Abstract Increasing evidence suggests that vision impairment may be an important modifiable risk factor for dementia, particularly in low- and middle-income settings where the prevalence of uncorrected vision impairment is high. Although prior studies in various settings, including India, have found strong associations between vision impairment and cognition, this work has not considered potential bias in cognitive testing due to vision impairment. We evaluated and adjusted for measurement differences by vision impairment status using data from the Longitudinal Aging Study in India–Diagnostic

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Arora, Sonakshi. "33 Title: Examining memory performances in a sample of cognitively healthy illiterate older adult population in India." Journal of the International Neuropsychological Society 29, s1 (2023): 445–46. http://dx.doi.org/10.1017/s1355617723005842.

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Objective:Despite the rise in literacy, 773 million of the global population is estimated to be illiterate. The rate of illiteracy is even higher among women and older adults (OA). Literacy has been well documented to impact cognitive skills, and most neuropsychological tests developed are for individuals with higher education. Moreover, there is sparse research on cognitive process and performance of illiterate individuals across cognitive domains.Per a 2011 census, the illiteracy rate in the Indian older adult population was as high as 56%, and within this group, women and older adults in ru

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Lee, Jinkook, Sarah Petrosyan, Pranali Khobragade, et al. "Deep phenotyping and genomic data from a nationally representative study on dementia in India." Scientific Data 10, no. 1 (2023). http://dx.doi.org/10.1038/s41597-023-01941-6.

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AbstractThe Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respon

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Zhao, Wei, Jennifer A. Smith, Yi Zhe Wang, et al. "Polygenic risk scores for Alzheimer’s disease and general cognitive function are associated with measures of cognition in older South Asians from LASI-DAD." Journals of Gerontology: Series A, February 14, 2023. http://dx.doi.org/10.1093/gerona/glad057.

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Abstract Genome-wide association studies (GWAS) conducted in European ancestry (EA) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with general cognitive function and/or Alzheimer’s disease (AD). The association between these SNPs and cognitive function has not been fully evaluated in populations with complex genetic sub-structure such as South Asians. This study investigated whether SNPs identified in EA GWASs, either individually or as polygenic risk scores (PRS), were associated with general cognitive function and five cognitive domains in 932 South Asians fro

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Banerjee, Joyita, Sarah Petrosyan, Abhijith R. Rao, et al. "Cohort Profile: Real-Time Insights of COVID-19 in India (RTI COVID-India)." BMC Public Health 23, no. 1 (2023). http://dx.doi.org/10.1186/s12889-023-15084-1.

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Abstract Background The coronavirus disease (COVID) pandemic caused disruption globally and was particularly distressing in low- and middle-income countries such as India. This study aimed to provide population representative estimates of COVID-related outcomes in India over time and characterize how COVID-related changes and impacts differ by key socioeconomic groups across the life course. Methods The sample was leveraged from an existing nationally representative study on cognition and dementia in India: Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India

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Angrisani, Marco, Nicholas S. Reed, Joyita Banerjee, and Jinkook Lee. "Dementia caregiving in India: New evidence from a National representative sample." Alzheimer's & Dementia 21, no. 5 (2025). https://doi.org/10.1002/alz.70266.

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AbstractINTRODUCTIONAs India's population ages, the prevalence of dementia is increasing rapidly, inducing higher need for informal caregivers for a complex population. However, the effects of individuals' cognitive impairment on their caregivers' well‐being in India have not been well studied.METHODSWe analyzed data from 4196 informants of participants in the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia (LASI‐DAD). Informants' caregiving roles and well‐being, including stress, mental health, positive affect, and spirituality, were assessed alongside the cognitive functi

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Keller, Brenton James, Jinkook Lee, Arthur W. Toga, Jorge Jovicich, and NA NA. "Investigating neural correlates of mild cognitive impairment using estimated clinical status from neuropsychological test battery: LASI‐DAD." December 7, 2020. https://doi.org/10.1002/alz.038440.

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AbstractBackgroundHaving ways to quickly assess cognitive impairment is critical for developing nations. Here we examine how different combinations of neuropsychiatric tests identify cognitive impairment using the Longitudinal Aging Study in India ‐ Diagnostic Assessment of Dementia (LASI‐DAD). We then investigate for brain regions that show structural morphological differences between cognitive impairment and cognitive normal groups.MethodsA total of 103 subjects (female = 46, age = 68 ± 6 years) were studied from three clinical 3T MRI centers using the ADNI 3 MRI protocol (NIMHANS, Bangalore

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Bhagwasia, Manjusha, Abhijith R. Rao, Joyita Banerjee, et al. "Association Between Cognitive Performance and Nutritional Status: Analysis From LASI-DAD." Gerontology and Geriatric Medicine 9 (January 2023). http://dx.doi.org/10.1177/23337214231194965.

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Malnutrition in low- and middle-income countries causes cognitive decline and other health problems. Harmonized Diagnostic Assessment of Dementia for Longitudinal Aging Study in India (LASI DAD) is an extensive study on late-life cognition and dementia. This study examines the link between nutrition and cognitive abilities in older adults using data from the LASI DAD. We conducted descriptive statistics on nutritional parameters (body-mass index, waist-hip ratio, and Mini-Nutritional Assessment), cognitive functions, and socio-demographic variables in 2,892 adults aged ≥60 years. Cognitive dom

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Abu‐Amara, Hasan, Wei Zhao, Zheng Li, et al. "Indian‐enriched genetic variants are associated with cognitive function." Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.093199.

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AbstractBackgroundThe prevalence of dementia in India is approximately 7.4% among those aged 60 years and older, yet little is known about genetic risk factors for dementia in this population. Examining genetic variants at higher frequency in India than other ancestries (i.e., Indian enriched variants) presents an opportunity to detect genetic effects which might be unique to the Indian population and/or underpowered for detection in other ancestral groups. We examined associations between Indian‐enriched variants and cognitive outcomes in 2680 older adults from the Longitudinal Aging Study in

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Jayakody, Oshadi, Joe Verghese, and Helena M. Blumen. "A cross‐national comparison of the risk factors associated with the Motoric Cognitive Risk syndrome in high and middle‐income countries." Alzheimer's & Dementia 19, S18 (2023). http://dx.doi.org/10.1002/alz.072272.

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AbstractBackgroundThe Motoric Cognitive Risk (MCR) syndrome is associated with increased risk of Alzheimer’s disease and vascular dementia. MCR does not require cognitive or lab tests to diagnose, increasing its utility in resource‐poor settings. The specific risk factors associated with MCR in different high‐ and middle‐income countries are not established.MethodsWe examined the epidemiology of MCR in harmonized cross‐sectional data from 17,050 adults aged ≥ 65 years enrolled in the U.S. Health and Retirement Study (HRS; n = 3,748), English Longitudinal Study of Ageing (ELSA; n = 4,110), Mexi

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Beerapalli, Sai Sanhitha. "Identifying feature relevance for transition from Questionable‐ to Low‐ AD using Interpretable‐AI." Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.084397.

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AbstractBackgroundIn the face of increasing Mild Cognitive Impairment(MCI) and Dementia rates among aging populations, understanding the factors shaping the non‐normal cognitive decline is crucial. Leveraging the Clinical Dementia Rating (CDR) data, this study has a dual focus. (1) It utilizes CDR to aid early MCI diagnosis by investigating factors contributing to transition from Questionable‐ to Low‐ AD. (2) It undertakes a comparative analysis between Indian and Caucasian populations, acknowledging cultural influences on cognitive health.MethodSHAP analysis (Lundberg et al, 2017), a game‐the

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Khobragade, Pranali Y., Sarah Petrosyan, Sharmistha Dey, A. B. Dey, and Jinkook Lee. "Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2." Journal of the American Geriatrics Society, October 31, 2024. http://dx.doi.org/10.1111/jgs.19252.

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AbstractThe rising burden of dementia calls for high‐quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI‐DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow‐up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older. Respondents underwent a battery of cognitive tests, geriatric assessments, and venous blood

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Lee, Jinkook, and Aparajit B. Dey. "Introduction to LASI‐DAD: The Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia." Journal of the American Geriatrics Society 68, S3 (2020). http://dx.doi.org/10.1111/jgs.16740.

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Ali, Istikhar, and Aparajit Ballav Dey. "Everyday Life of People Living with Dementia and its Impact on Their Lifestyle." Alzheimer's & Dementia 20, S4 (2024). https://doi.org/10.1002/alz.085831.

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AbstractBackgroundThis ethnographic inquiry offers a nuanced exploration into the lives of individuals contending with dementia in India, utilizing data from the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI‐DAD). Recognizing dementia as a complex global health challenge, we delve into its unique manifestations within India’s diverse regional and cultural landscape. While LASI‐DAD provides valuable quantitative insights into prevalence and risk factors, our research complements these statistics by providing an in‐depth understanding of the daily l

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Myers, Clarice A., Wuyang Zhang, Niranjani Nagarajan, et al. "Dual sensory loss and cognitive performance among older adults in India." Journal of Alzheimer’s Disease, July 30, 2025. https://doi.org/10.1177/13872877251362829.

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Background Hearing loss (HL) and vision loss (VL) occur frequently among older adults and are independent risk factors for dementia, including in low- and middle-income countries (LMICs), where incident dementia is common. There is little research on the prevalence of dual sensory loss (DSL) and its association with cognitive health in LMICs. Objective This study investigates cross-sectional associations between DSL and cognitive performance among older adults in India. Methods Data (3,201) was analyzed from Wave I (2017–18) of the Longitudinal Aging Study in India (LASI) and Waves I (2017–201

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Abu‐Amara, Hasan, Wei Zhao, Zheng Li, et al. "Gene‐Based Analysis with Functional Annotation in 2680 South Asians from the LASI‐DAD Study." Alzheimer's & Dementia 19, S22 (2023). http://dx.doi.org/10.1002/alz.076905.

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AbstractBackgroundThe prevalence of dementia among South Asians across India is as high as 10% in those 55 years and older, yet little is known about the risk dementia factors in this population. To date, most known genetic risk loci of Alzheimer’s disease (AD) were identified from studies conducted in European Ancestry (EA) participants. The full mutational spectrum and the functional relevance of those loci in South Asians remains unknown. Analyzing DNA sequence data poses challenges due to the large number of rare variants tested, with most variants likely not associated with dementia. Thes

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Lee, Jinkook, Pranali Y. Khobragade, Joyita Banerjee, et al. "Design and Methodology of the Longitudinal Aging Study in India‐Diagnostic Assessment of Dementia ( LASI‐DAD )." Journal of the American Geriatrics Society 68, S3 (2020). http://dx.doi.org/10.1111/jgs.16737.

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Petrosyan, Sarah, Miguel Arce Renteria, Jennifer J. Manly, Shrikanth Narayanan, and Jinkook Lee. "Effects of multilingualism on cognition among older Indian adults in the nationally representative LASI‐DAD study." Alzheimer's & Dementia 18, S7 (2022). http://dx.doi.org/10.1002/alz.065968.

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Bajpai, Swati, Ashish Dutt Upadhayay, Joyita Banerjee, et al. "Discrepancy in Fluid and Crystallized Intelligence: An Early Cognitive Marker of Dementia from the LASI-DAD Cohort." Dementia and Geriatric Cognitive Disorders Extra, April 4, 2022, 51–59. http://dx.doi.org/10.1159/000520879.

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<b><i>Background:</i></b> Cognitive aging is a complex phenomenon, which comprises various cognitive skills, broadly categorized into fluid and crystallized intelligence. Crystallized intelligence (gc) tends to be maintained, as opposed to fluid intelligence (gf), which tends to decline rapidly with age. The association of the two with cognitive decline remains a matter of conjecture requiring further research. <b><i>Aim:</i></b> The aim of the study was to identify the variables of gc and gf from a population data of Longitudinal Aging Study in

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Keller, Brenton James, Jinkook Lee, Arthur W. Toga, and Jorge Jovicich. "Investigating neural correlates of mild cognitive impairment using estimated clinical status from neuropsychological test battery: LASI‐DAD." Alzheimer's & Dementia 16, S10 (2020). http://dx.doi.org/10.1002/alz.038440.

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Ala, Saritha, Jangra Rohit, Bhat Lekha, and Elezebeth Philip Neena. "Knowledge, attitude, and practice among the Indian population regarding COVID-19 using LASI-DAD COVID-19 data." International Journal of Public Health Science (IJPHS) 14, no. 2 (2025). https://doi.org/10.11591/ijphs.v14i2.23836.

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During the COVID-19 pandemic, India was one of the worst-hit countries in terms of the number of cases and deaths. Knowledge, attitude, and practice play an important role in reducing disease transmission. This study uses a nationally represented large data set to understand the knowledge, attitude, and practice (KAP) of COVID-19 among the Indian population. This cross-sectional study utilized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) COVID-19 data which provides information on respondents’ demographics, socioeconomic effects, health status, b

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Ehrlich, Joshua R., Emma Nichols, Yizhou Chen, et al. "The influence of vision impairment on the measurement of cognition in older adults in India: Findings from LASI-DAD." Innovation in Aging, August 9, 2024. http://dx.doi.org/10.1093/geroni/igae071.

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Abstract Background and Objectives Prior investigations have not considered whether poor vision biases cognitive testing. However, such research is vital given increasing evidence that vision impairment (VI) may be an important modifiable risk factor for dementia, particularly in low- and middle-income settings where the prevalence of VI is high. Research Design and Methods This study employed data from 3,784 participants in Wave 1 of the Longitudinal Aging Study in India–Diagnostic Assessment of Dementia (LASI-DAD) who underwent both visual acuity and cognitive function testing. We used multi

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Wang, Yi Zhe, Wei Zhao, Aparajit Ballav Dey, Jinkook Lee, Jennifer A. Smith та Sharon L. R. Kardia. "Effect of APOE ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI‐DAD". Alzheimer's & Dementia 19, S12 (2023). http://dx.doi.org/10.1002/alz.076581.

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AbstractBackgroundThe ε4 allele of the apolipoprotein E (APOE) gene is the most significant genetic risk factor for dementia in nearly all human populations. However, the effects of APOE ε4 on late‐life cognitive function and its potential modification by sociodemographic factors have not been extensively studied in South Asians. We investigated the effects of APOE ε4 and its interaction with sociodemographic characteristics on cognitive measures in 2,607 South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI‐DAD).MethodWe determined APOE ε4 car

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Wang, Yi Zhe, Wei Zhao, Elise Kerdoncuff та ін. "Geographic and ancestral variation in the association between APOE ε4 and cognitive function in South Asians from LASI‐DAD". Alzheimer's & Dementia 20, S1 (2024). https://doi.org/10.1002/alz.092646.

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AbstractBackgroundThe ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic determinant for Alzheimer’s disease and cognitive function in nearly all human populations, yet inconsistent effects have been reported in South Asians. The population of India has admixed genetic ancestry with most people falling on a North/South cline and having varying proportions of Ancestral North Indian (ANI) and Ancestral South Indian (ASI) ancestries, and those in east of India fall off the cline due to ancestry from additional ancestral populations. This study examined the ε4 association with

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Zhao, Wei, Jennifer A. Smith, Miao Yu, et al. "Common and rare variants in Alzheimer’s disease genes are associated with episodic memory in South Asians from the LASI‐DAD study." Alzheimer's & Dementia 16, S3 (2020). http://dx.doi.org/10.1002/alz.045189.

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Wang, Yi Zhe, Wei Zhao, Priya Moorjani та ін. "Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI‐DAD". Alzheimer's & Dementia, 18 червня 2024. http://dx.doi.org/10.1002/alz.14052.

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AbstractBACKGROUNDWe investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI‐DAD).METHODSLinear regression was used to assess the association between APOE ε4 and global‐ and domain‐specific cognitive function in 2563 participants (mean age 69.6 ± 7.3 years; 53% female). Effect modification by age, sex, and education were explored using interaction terms and subgroup analyses.RESULTSAPOE ε4 was inversely associ

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Khobragade, Pranali, Emma Nichols, Erik Meijer, et al. "Performance of the Informant Questionnaire on Cognitive Decline for the Elderly (IQCODE) in a nationally representative study in India: the LASI-DAD study." International Psychogeriatrics, July 18, 2022, 1–11. http://dx.doi.org/10.1017/s1041610222000606.

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ABSTRACT Background: Low and middle-income countries like India anticipate rapid population aging and increases in dementia burden. In India, dementia screening scales originally developed in other contexts need to be assessed for feasibility and validity, given the number of different languages and varying levels of literacy and education. Method: Using data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (N = 4,028), we characterize the performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). We described patterns and correlates of

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Winchester, Laura M., Danielle Newby, Sarah Bauermeister, et al. "The role of anemia and haemoglobin concentration on cognitive function in the Longitudinal Ageing Study of India‐Diagnostic Assessment of Dementia (LASI‐DAD)." Alzheimer's & Dementia 19, S8 (2023). http://dx.doi.org/10.1002/alz.066687.

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Nichols, Emma, Michael Markot, Alden L. Gross, et al. "The added value of metadata on test completion time for the quantification of cognitive functioning in survey research." Journal of the International Neuropsychological Society, January 9, 2025, 1–10. https://doi.org/10.1017/s1355617724000742.

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Abstract Objective: Information on the time spent completing cognitive testing is often collected, but such data are not typically considered when quantifying cognition in large-scale community-based surveys. We sought to evaluate the added value of timing data over and above traditional cognitive scores for the measurement of cognition in older adults. Method: We used data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) study (N = 4,091), to assess the added value of timing data over and above traditional cognitive scores, using item-specific regression

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Nichols, Emma, Karla R. Flores Romero, Dipti Govil, Jinkook Lee, and Jaqueline M. Torres. "The association between adult child education and cognitive functioning among older parents: A cross‐national comparison of diverse contexts." Alzheimer's & Dementia, January 27, 2025. https://doi.org/10.1002/alz.14562.

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AbstractINTRODUCTIONThe association between adult child educational attainment and older parent's cognitive health may vary across diverse contexts but cross‐national comparisons have been limited by differences in outcome assessment, study design, and analytic choices.METHODSWe used harmonized data with comprehensive cognitive assessments from the United States (N = 3088), India (N = 3828), and Mexico (N = 1875) to estimate associations between adult child education and older adults’ cognitive functioning using linear regression models adjusted for respondent and family‐level socio‐economic s

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Smith, Jennifer A., Wei Zhao, Miao Yu, et al. "Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India–Diagnostic Assessment of Dementia (LASI‐DAD)." Journal of the American Geriatrics Society 68, S3 (2020). http://dx.doi.org/10.1111/jgs.16735.

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Marmamula, Srinivas, Suvarna Alladi, Keerthana Umapathy, et al. "Cognitive Level Enhancement through Vision Exams and Refraction (CLEVER): study protocol for a randomised controlled trial." Trials 26, no. 1 (2025). https://doi.org/10.1186/s13063-025-08813-x.

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Abstract Background Longitudinal observational studies have found an association between vision impairment and accelerated decline in cognition. However, no randomised trials have assessed the possible benefit of vision correction on cognitive change. We present the protocol for a three-year randomised controlled trial designed to assess the impact of spectacles for distance and/or near vision correction on cognitive change among community-dwelling elderly participants in India. Methods Cognitive Level Enhancement through Vision Exams and Refraction (CLEVER) is a single-centre, open-label, par

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Singhal, Sunny, Sumitabh Singh, Gevesh Chand Dewangan, et al. "The prevalence of frailty and its relationship with sociodemographic factors, regional healthcare disparities, and healthcare utilization in the aging population across India." AGING MEDICINE, August 7, 2023. http://dx.doi.org/10.1002/agm2.12263.

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AbstractBackgroundThe burden of frailty in developing countries and its relationship with complex social structures, such as caste, religion, and regional health care differences and its effect on health care outcomes are not well‐characterized. The aim of the study was to estimate frailty prevalence and its relationship with the socio‐economic and regional factors and health care outcomes.MethodsIn this study, participants from the harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI‐DAD) were included. The frailty index (FI) was calculated using a 32‐v

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