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1

Yahalomi, Tal, Asaf Achiron, Roee Arnon, Nir Stanescu, and Joseph Pikkel. "Dry Eye Disease following LASIK, PRK, and LASEK: An Observational Cross-Sectional Study." Journal of Clinical Medicine 12, no. 11 (May 30, 2023): 3761. http://dx.doi.org/10.3390/jcm12113761.

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Dry eye disease is the most frequent non-refractive postoperative complication following refractive surgery. This prospective study investigated the development of dry eye disease after three common refractive laser surgeries: laser in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and laser-assisted sub-epithelial keratectomy (LASEK). Patients who underwent uneventful refractive surgery in a single private medical center between May 2017 and September 2020 were included. Ocular surface disease was graded according to the Dry Eye Workshop severity (DEWS) classification. Patients were examined 6 months following refractive surgery. The analysis included 251 eyes of 137 patients: 64 eyes (36 patients) after LASEK, 90 eyes (48 patients) after PRK, and 97 eyes (53 patients) after LASIK. At 6 months post-surgery, the DEWS score was higher for the LASIK than the PRK and LASEK groups (p = 0.01). For the total cohort, severe DEWS score (grades 3 and 4) at 6 months post-surgery was correlated with female gender (p = 0.01) and to the amount of refractive correction (p < 0.001), but not to age (p = 0.87). In conclusion, LASIK surgery and female gender were associated with dry eye. Patients, particularly those with high myopia, should be counseled about the risk of developing dry eye after refractive surgeries.
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2

&NA;. "LASIK Eye Surgery." Nurse Practitioner 29, no. 4 (April 2004): 51. http://dx.doi.org/10.1097/00006205-200404000-00011.

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3

Sitzman, Kathy. "LASIK Eye Surgery Basics." AAOHN Journal 54, no. 2 (February 2006): 92. http://dx.doi.org/10.1177/216507990605400207.

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4

Dr. Sana Abdalziz Qzir Alasadi, Dr. Rabeeha Khassaf Abbas Alkhafagi, and Dr. Mohammed Hamza Rashid. "Advancements in Laser Eye Surgery Through Sectional Study." INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES 3, no. 1 (January 11, 2024): 23–32. http://dx.doi.org/10.51699/ijhsms.v3i1.3297.

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Background: Laser in situ corneal surgery (LASIK) This technique has been considered as the most widespread and most widely performed refractive intervention in eye surgery in the world, which may show a high satisfaction index among patients after surgery. Objective: This study aimed to evaluate the results of vision quality for patients suffering from myopia and astigmatism after LASIK surgery. Patients and methods: We conducted a cross-sectional study of 74 patients ages 28-54 who suffered from myopia and astigmatism who underwent LASIK surgery. This study extended from February 16, 2022, to September 9, 2023. This study determined the importance of LASIK surgery in improving the visual function of patients in the long term in terms of satisfaction and happiness after surgery, functional improvement, and achieving the expected quality of vision. Results: Our results found that the percentage of males, which included 47 patients, was greater than that of females, which included 27 patients. The data for both surgery time were (22.46 ± 0.8) minutes, and corneal thickness was (498 ± 4.0 microns, recovery time was (3.6 ± 2.4) days. Our outcomes found that the surgery to be a good option, and it was 98%. The main goal was achieved. It was 96%. They were satisfied with the result. It was 95.40%. Happiness after LASIK was 99%. Conclusion: LASIK surgery has shown that the surgical procedure is the most healing, the quickest to perform, and the safest, which increases functional improvement and which contributes significantly. Great quality optical resolution. Our results confirm that there is great patient satisfaction with LASIK surgery, which is attributed to the quality of this surgery, which improves visual ability in a safer and more accurate way.
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5

Kates, Malcolm M., and Sonal Tuli. "What Is LASIK Eye Surgery?" JAMA 324, no. 8 (August 25, 2020): 815. http://dx.doi.org/10.1001/jama.2020.1286.

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6

Barbara, Ramez, and Adel Barbara. "Late-onset Post-lasik Ectasia with no Apparent Risk Factor except Eye Rubbing: A Case Report and Literature Review." International Journal of Keratoconus and Ectatic Corneal Diseases 5, no. 2 (2016): 85–91. http://dx.doi.org/10.5005/jp-journals-10025-1127.

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ABSTRACT Post-lasik ectasia is the most feared complication following lasik, occurring in majority of cases within 1 year of surgery. Furthermore, it is reported many years after surgery. In this case report, we describe and analyze a post-lasik ectasia case in one eye which was diagnosed after 11 years without any risk factor or apparent reason except eye rubbing. How to cite this article Barbara A, Barbara R. Late-onset Post-lasik Ectasia with no Apparent Risk Factor except Eye Rubbing: A Case Report and Literature Review. Int J Kerat Ect Cor Dis 2016;5(2):85-91.
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7

Zhao, Lu, Yu Zhang, Hongyu Duan, Tingting Yang, Yifan Zhou, Baikai Ma, Yueguo Chen, and Hong Qi. "Clinical Characteristics and Tear Film Biomarkers in Patients With Chronic Dry Eye Disease After Femtosecond Laser–Assisted Laser in Situ Keratomileusis." Journal of Refractive Surgery 39, no. 8 (August 2023): 556–63. http://dx.doi.org/10.3928/1081597x-20230717-02.

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Purpose: To investigate clinical characteristics and tear film biomarkers of patients with chronic dry eye disease (DED) following femtosecond laser–assisted laser in situ keratomileusis (FS-LASIK). Methods: Patients were divided into the chronic DED after FS-LASIK (n = 36), DED without FS-LASIK (n = 39), and normal control (without FS-LASIK; n = 34) groups. Dry eye, pain, and psychological-related symptoms were evaluated using the Ocular Surface Disease Index (OSDI), Numerical Rating Scale (NRS), Neuropathic Pain Symptom Inventory Modified for the Eye (NPSI-Eye), and Hamilton Anxiety Rating Scale (HAMA) questionnaires. Ocular surface parameters, tear cytokines, and neuropeptide concentrations were evaluated with specific tests. Results: The DED after FS-LASIK group showed higher corneal fluorescein staining scores, but lower OSDI and NPSI-Eye scores than the DED without FS-LASIK group (all P < .05). Corneal sensitivity and nerve density decreased in the DED after FS-LASIK group (all P < .01). Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-17A, IL-23, alpha-melanocyte stimulating hormone (α-MSH), oxytocin, and substance P levels were highest in the DED after FS-LASIK group, followed by the DED without FS-LASIK and normal control groups (all P < .05). Interferon-γ and neurotensin levels were only significantly higher in the DED after FS-LASIK group (all P < .05). Conclusions: Patients with chronic DED after FS-LASIK showed milder ocular symptoms, greater epithelial damage, and higher levels of tear inflammatory cytokines and neuropeptides than patients with DED without FS-LASIK, indicating that the nervous and immune systems may play significant roles in FS-LASIK-related chronic DED development. [ J Refract Surg . 2023;39(8):556–563.]
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8

Ratnaningsih, Elly. "PERSEPSI TERHADAP PELAYANAN OPERASI LASIK DI RUMAH SAKIT MATA MASYARAKAT JAWA TIMUR." Medical Technology and Public Health Journal 2, no. 2 (October 29, 2018): 128–32. http://dx.doi.org/10.33086/mtphj.v2i2.565.

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Visiting of lasik surgery patients at Eye Hospital of East Java in 2016 is quite low (9%) whilein 2017 increased (10%) but still below target. Such low achievements are likely to be influenced byconsumer perceptions of lasik surgery services. This study aims to assess the community perceptionof lasik surgery services Eye Hospital of East Java. Assessment of perception includes price, people,process and physical evidence. This study shows that respondents' perceptions of lasik surgery ratesare cheaper than those in other hospitals. Overall perception of officers and service process lasiksurgery is good. While the perception of respondents to the physical appearance has not been good,because respondents feel not satisfied with hospital facilities. This research recommends innovationin marketing efforts lasik surgery service and hospital management need to improve infrastructurefacilities.
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9

Miraditi, Ni Komang. "Dry Eyes Post Laser Assisted in Situ Keratomileusis." KESANS : International Journal of Health and Science 1, no. 3 (December 20, 2021): 261–68. http://dx.doi.org/10.54543/kesans.v1i3.26.

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Dry eye is one of the most common complications following laser-assisted in situ keratomileusis (LASIK), with nearly all patients experiencing some degree of postoperative dry eye symptoms. Postoperative dry eye affects approximately 50% of patients at 1 week postoperatively, 40% at 1 month, and 20%-40% at 6 months postoperatively. LASIK can cause intracorneal nerve damage, goblet cell damage caused by suction, and can cause changes in the shape of the central cornea. Dry eye diagnosis can be made using a questionnaire to determine the patient's history, examination of tear break up time, staining of the eye surface using fluorescein or lissamine green, and Schirmer's test. This reserech use Literatur Review Method. Post-LASIK dry eye complaints such as irritation, red eyes, foreign body sensation, pain, gritty, and photophobia. Management of post-LASIK dry eyes can be done by giving tear supplements, anti-inflammatory agents, ointments and eye patches, and treatment of meibomian gland dysfunction. Post-LASIK dry eye usually peaks within a few months after surgery, and then improves in most patients 6-12 months after surgery. Although dry eye signs and symptoms are most common in the immediate postoperative period and are usually only temporary, a minority of individuals experience chronic and severe dry eye
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10

Astakhov, Sergey Yu, and Inna A. Riks. "Experience in Gilan Comfort eye drops use of in patients after excimer laser surgery." Ophthalmology journal 10, no. 4 (December 15, 2017): 57–60. http://dx.doi.org/10.17816/ov10457-60.

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The article presents treatment results of the dry eye syndrome after excimer laser refractive surgery (LASIK). This procedure often leads to dry eye symptoms and signs, so there should be a mandatory prescription of lubricative eye drops for up to 3-6 months. For treatment, non-preserved Gilan Comfort containing hyaluronic acid (Russian Federation trade mark) was used. The study included 30 patients after LASIK who received Gilan Comfort 4 times a day for 3 months. Treatment was well tolerated; there were no adverse effects in any of the patients. The treatment results observed in all 30 people consisted in distinct decrease of dry eye symptoms after 3 months of Gilan Comfort instillations after LASIK surgery. (For citation: Astakhov SYu, Riks IA. Experience in Gilan Comfort eye drops use of in patients after excimer laser surgery. Ophthalmology Journal. 2017;10(4):57-60. doi: 10.17816/OV10457-60).
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11

Wang, Bingjie, Rajeev K. Naidu, Renyuan Chu, Jinhui Dai, Xiaomei Qu, and Hao Zhou. "Dry Eye Disease following Refractive Surgery: A 12-Month Follow-Up of SMILE versus FS-LASIK in High Myopia." Journal of Ophthalmology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/132417.

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Purpose.To compare dry eye disease following SMILE versus FS-LASIK.Design.Prospective, nonrandomised, observational study.Patients.90 patients undergoing refractive surgery for myopia were included. 47 eyes underwent SMILE and 43 eyes underwent FS-LASIK.Methods.Evaluation of dry eye disease was conducted preoperatively and at 1, 3, 6, and 12 months postoperatively, using the Salisbury Eye Evaluation Questionnaire (SEEQ) and TBUT.Results.TBUT reduced following SMILE at 1 and 3 months (p<0.001) and at 1, 3, and 6 months following FS-LASIK (p<0.001). TBUT was greater following SMILE than FS-LASIK at 3, 6, and 12 months (p<0.001,p<0.001, andp=0.009, resp.). SEEQ scores increased (greater symptoms) following SMILE at 1 month (p<0.001) and 3 months (p=0.003) and at 1, 3, and 6 months following FS-LASIK (p<0.001). SMILE produced lower SEEQ scores (fewer symptoms) than FS-LASIK at 1, 3, and 6 months (p<0.001).Conclusion.SMILE produces less dry eye disease than FS-LASIK at 6 months postoperatively but demonstrates similar degrees of dry eye disease at 12 months.
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12

Liu, Hongting, Qi Chen, Fangfang Lan, Yan Luo, Enwei Lin, Wuqiang Luo, Ming Kong, Jiangxia Wang, and Fengju Zhang. "The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia." Journal of Ophthalmology 2020 (April 1, 2020): 1–8. http://dx.doi.org/10.1155/2020/3873740.

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Purpose. To evaluate the effect of laser refractive surgery on sensory eye dominance of anisometropia. Methods. A total of 156 subjects with nonanisometropic myopia and 70 subjects with anisometropic myopia were enrolled in the first part of the study. The dichoptic motion coherence threshold technique was applied to collect the normal dataset and distribution of sensory eye dominance. The second part of the study included 40 subjects with nonanisometropic myopia and 40 subjects with anisometropic myopia who received the femtosecond laser-assisted in situ keratomileusis (Fs-LASIK). A comprehensive ophthalmologic evaluation was performed with particular attention to sensory eye dominance preoperatively and one-week and one-month postoperatively. The ocular dominance index (ODI) was applied to evaluate the subject’s overall degree of sensory ocular dominance. Visual acuity, sighting eye dominance, and stereo acuity were also accessed. Results. In experiment one, the mean ODI in the nonanisometropic group and the anisometropic group was 1.48 ± 0.63 and 1.95 ± 1.07, respectively. The ODI values of the anisometropic group were significantly higher than those of the nonanisometropic group (Mann–Whitney U test, P<0.001). The demographics information and the distribution of ODI values in both groups are summarized in tables and figures. In experiment two, all LASIK procedures were uneventful and no postoperative complications were observed during the postoperative follow-up. Preoperatively, the ODI values of the anisometropic LASIK group were significantly higher than those of the nonanisometropic LASIK group, which was consistent with the results of part 1. However, one week after operation, the mean ODI values of the anisometropic LASIK group had significantly decreased from 1.89 ± 1.09 to 1.39 ± 0.44. And, the mean ODI values slightly increased to 1.65 ± 0.61 one-month postoperatively. In the nonanisometropic LASIK group, there were no statistically significant differences of ODI changes among preoperative, post-one-week and post-one-month visits. The demographics information and the changes of ODI of both LASIK groups are summarized in tables and figures. Conclusion. Stronger sensory eye dominance is seen in the subjects with anisometropic myopia compared to subjects with nonanisometropic myopia. The strong sensory dominance of anisometropia becomes more balanced at one week of postoperation but returns to the preoperative level after one month. Laser refractive surgery had a short-term modulation of sensory eye dominance.
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13

Ouano, Dean, Rachel Huynh, Alyson Nicole Tukan, Nour Bundogji, and Majid Moshirfar. "To Amputate or Not to Amputate: Management of Iatrogenic LASIK Flap Dehiscence and Epithelial Ingrowth with Overlying Pseudopterygium." Case Reports in Ophthalmology 12, no. 3 (December 20, 2021): 967–74. http://dx.doi.org/10.1159/000519628.

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A 73-year-old male with a history of myopic laser-assisted in situ keratomileusis (LASIK) 20 years earlier presented with a late LASIK flap dehiscence, epithelial ingrowth, conjunctivalization, and the development of a pseudopterygium in the right eye. The findings were consistent with surgical trauma, likely occurring after corneal epithelial debridement to improve visualization during pars plana vitrectomy for retinal detachment repair 3 months earlier. The patient underwent epithelial ingrowth debridement, LASIK flap reapproximation and suturing, and a conjunctival limbal autograft from the contralateral eye. The surgery was completed successfully without the need for flap amputation. Postoperatively, the patient had an uneventful course with a well-healing conjunctival graft and no interface opacity or evidence of recurrent pseudopterygium of the right eye. The graft and corneal topography remained stable after subsequent cataract surgery.
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14

Taylan Sekeroglu, H., E. Erdem, K. Yar, M. Yağmur, T. R. Ersoz, and A. Uguz. "A Rare Devastating Complication of Lasik: Bilateral Fungal Keratitis." Journal of Ophthalmology 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/450230.

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Purpose. To report an unusual case of severe bilateral fungal keratitis following laser in situ keratomileusis (LASIK).Method. A 48-year-old man developed bilateral diffuse corneal infiltration two weeks after LASIK. The corneal scrapings revealed fungal filaments but cultures were negative.Results. The corneal ulceration was improved on the left eye whereas spontaneous perforation occurred and finally evisceration was needed on the right eye despite topical and systemic antifungal treatment.Conclusions. Fungal keratitis, especially with bilateral involvement, is a very rare and serious complication of LASIK surgery. Clinical suspicion is crucial because most of fungal keratitis are misdiagnosed as bacterial keratitis and can lead serious visual results, even eye loss.
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15

Chung, AKK, and AK Brahma. "LASIK eye surgery: standard and safety issues." Clinical Risk 12, no. 2 (March 1, 2006): 70–73. http://dx.doi.org/10.1258/135626206776072622.

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16

Black, Sondra. "Successful Restoration of Visual Acuity with an Extended Range of Vision Intraocular Lens after Multifocal Laser Ablation." Case Reports in Ophthalmology 7, no. 3 (October 11, 2016): 471–75. http://dx.doi.org/10.1159/000450675.

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As our baby boomer population is aging and developing cataracts, so are our post-LASIK patients. These patients underwent LASIK surgery as they wished to be spectacle-free and are hoping to remain so after intraocular lens (IOL) surgery. Unfortunately, very little information is available regarding the suitability of presbyopia correcting IOLs for post-LASIK patients. This case represents successful implantation of an extended range of vision IOL in a 59-year-old patient who underwent multifocal ablation excimer laser surgery 12 years before. Emmetropia was targeted for the dominant eye and –0.5 D for the fellow eye. The 13 month follow-up after bilateral implantation of the TECNIS Symfony IOL revealed an uncorrected visual acuity of 20/25 for distance, 20/20 for intermediate and 20/16 for near. The patient is very happy and did not report any visual symptoms when asked. This successful case should encourage surgeons to consider implanting an extended range of vision IOLs in post-LASIK patients.
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Chang, Hao-Yun, and Wei-Ting Ho. "Self-limited corneal ectasia in a post-LASIK eye after cataract surgery: A case report." Medicine 102, no. 43 (October 27, 2023): e35322. http://dx.doi.org/10.1097/md.0000000000035322.

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Introduction: To present a case with a history of laser in situ keratomileusis (LASIK) developing central conic protrusion after phacoemulsification cataract surgery, which spontaneously resolved 5 months postoperatively. Patient concerns: A 55-year-old female who underwent myopic LASIK surgery 10 years ago presented to the clinic with bilateral cataracts and without ectasia. Following phacoemulsification cataract surgery and intraocular lens implantation in the right eye, the patient experienced a significant increase in spherical equivalent and corneal astigmatism. Diagnoses: Based on a central conic protrusion on topography examination, surgically-induced corneal ectasia was diagnosed. Interventions: Topical lubricants, corticosteroids, and serial follow-up with corneal topography. Outcomes: The corneal protrusion gradually resolved over a period of 5 months. Lessons: For post-LASIK patient who developed corneal protrusion following uneventful cataract surgery with a clear corneal incision, the clear corneal wound may have disrupted the biomechanical stability of the post-LASIK eye, compromising the peripheral stromal integrity. Additionally, postoperative inflammation could have contributed to corneal ectasia. Smaller clear corneal wounds or scleral tunnel entry during cataract surgery in post-LASIK eyes should be considered. Monitoring wound healing and using topical steroids can aid in achieving satisfactory outcomes and reducing the potential vision-threatening complications associated with corneal ectasia.
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18

Morgado, Claudia R., Marcony R. Santhiago, W. Allan Steigleman, Elizabeth M. Hofmeister, Maria A. Henriquez, Siamak Zarei-Ghanavati, Sonia H. Yoo, Soosan Jacob, and Julie Schallhorn. "Late approach for LASIK flap striae." Journal of Cataract and Refractive Surgery 49, no. 12 (December 2023): 1285–89. http://dx.doi.org/10.1097/j.jcrs.0000000000001342.

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A 24-year-old man was referred for postrefractive surgery evaluation. The patient had a history of uneventful laser in situ keratomileusis (LASIK) in both eyes 3 months previously. According to the surgeon who originally performed the surgery, on slitlamp examination, only microstriae in the left eye was detected on postoperative day 1 and a more conservative follow-up approach was adopted without further immediate intervention. The patient returned only 3 months after surgery, complaining of low vision in the left eye that, according to the patient, had been present since postoperative week 2. The patient was then referred for examination and surgical procedure with a diagnosis of significant postoperative striae. The slitlamp examination revealed a LASIK flap with striae, epithelial filling, and a wrinkled appearance (Figure 1 JOURNAL/jcrs/04.03/02158034-202312000-00017/figure1/v/2023-11-17T010223Z/r/image-tiff ). There were no signs of infection or inflammation. Originally, the LASIK flap was programmed to be 110 μm. Preoperative manifest refraction in the right eye was −5.25 (20/20) and in the left eye was −5.25 (20/20). Assuming it is a case of late-approach LASIK flap striae, how would you proceed? Would you try to hydrate and lift the flap and just reposition it? Would you avoid lifting and associate phototherapeutic keratectomy (PTK) with excimer laser on top of the flap? Would you consider topo-guided surgery with regularization of the visual axis or even amputation of the flap?
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19

Yumusak, Erhan, Kemal Ornek, and Fatma Ozkal. "Bilateral Simultaneous Rhegmatogenous Retinal Detachment following Laser in situ Keratomileusis." Case Reports in Ophthalmology 7, no. 2 (June 13, 2016): 340–44. http://dx.doi.org/10.1159/000446602.

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A 21-year-old woman developed simultaneous rhegmatogenous retinal detachment after laser in situ keratomileusis (LASIK) in both eyes. She underwent pars plana vitrectomy surgery combined with endolaser photocoagulation and silicone oil tamponade in the right eye. A week later, pneumatic retinopexy was done in the left eye. As the retinal tear did not seal, 360° scleral buckling surgery was performed and retina was attached. Bilateral simultaneous rhegmatogenous retinal detachment after LASIK for correction of myopia can be a serious complication. Patients should be informed about the possibility of this complication.
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Mohammadpour, Mehrdad, and Masoud Khorrami-Nejad. "Post-LASIK keratectasia in the context of a thicker than intended flap detected by anterior segment optical coherence tomography." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2110504. http://dx.doi.org/10.1177/2050313x211050462.

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The corneal flap created in LASIK is responsible for most of its advantages in comparison with surface ablation. However, lamellar dissection of the corneal layers in LASIK can also result in serious complications such as corneal ectasia. A 23-year-old man underwent LASIK for correction of −4.75 −2.00@15 in the right eye and −4.50 −2.00@160 in the left eye with a preoperative thinnest corneal thickness of 518 µm/right eye and 513 µm/left eye in 2009. An intended flap thickness and ablation depth in both eyes were 160 µm and 94 µm, respectively, and subsequently, residual stromal bed thickness was 264 µm/right eye and 259 µm/left eye. Several years after surgery, he was referred for the decreased vision. His corrected-distance visual acuity was 0.50 in both eyes. A scissoring reflex was found in retinoscopy. Orbscan imaging was compatible with keratoconus. Anterior segment optical coherence tomography was performed to measure the LASIK flap. It was much thicker (200 µm) than intended (160 µm), and therefore, the residual stromal bed thickness was much thinner. In summary, keratectasia may develop in cases where thicker than expected flaps result in excessive thinning of the residual stromal bed. The obtained results from this case emphasize and remind the importance of intraoperative measurement of flap thickness and using femtosecond and new criteria for patient selection to avoid post-LASIK keratectasia.
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Rati Shukla and Anjana Singh. "Emerging Technologies in Eye Sight Cor rection: Customers Perspective." Journal of Technology Management for Growing Economies 3, no. 1 (April 24, 2012): 63–78. http://dx.doi.org/10.15415/jtmge.2012.31004.

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LASIK (Laser in siter kerato milensis) is a form of refractive surgery which intends to correct eye sight error and reduces the need of other visual aids like glasses and contact lenses. With the emergence of latest technologies in the eye care, the aim of this paper is to explore the eye sight correction surgery: LASIK in the National Capital Region of Inida. It would further identify the market segments that have undergone the surgery or intend to do so in the future, hence highlighting the customers' perception about the same.The research explores upcoming technologies through personal interviews with Eye surgeons in the National Capital Region. The interviews specifically emphasize on the technological milestones in the eye correction area. Further, a questionnaire based survey was conducted, to evaluate customers experience and expectations from these eye care technologies. The study hence, provides a comprehensive overview of the technological high points in the eye sight correction. Also the paper focuses on the various apprehensions raised by customers relating to safety and pricing of these eye surgeries.
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Berguiga, Marouen, and Alain Saad. "Unilateral Post-LASIK Ectasia in a Topographical Normal Eye with a Slight Asymmetry in the Contralateral Eye." International Journal of Keratoconus and Ectatic Corneal Diseases 3, no. 1 (2014): 47–51. http://dx.doi.org/10.5005/jp-journals-10025-1078.

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ABSTRACT Purpose To report a case of post-LASIK unilateral corneal ectasia. Setting Department of anterior segment and Refractive surgery, Rothschild Foundation, Paris. Case report A 33-year-old woman was referred with a history of unilateral post-LASIK ectasia in her left eye, 18 months post operatively. Her best-corrected visual acuity was 20/20 with a manifest refraction of +1.75 (–4.75 × 90). Orbscan ii® revealed an inferior steepening associated with irregular astigmatism. The preoperative Placido topographies revealed a slight skewed radial axis in the right eye associated with an inferior-superior keratometry difference of 1.6 Diopters at 3 mm. in the left eye that developed ectasia, regular symmetric astigmatism was present. Uncorrected visual acuity improved to 20/25 2 weeks after keraRing® segment insertion. How to cite this article Berguiga M, saad a, Gatinel D. Unilateral Post-LASIK Ectasia in a Topographical Normal Eye with a slight asymmetry in the Contralateral Eye. int J kerat Ect Cor Dis 2014;3(1):47-51.
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Noda-Tsuruya, Tomoko, Naoko Asano-Kato, Ikuko Toda, and Kazuo Tsubota. "Autologous Serum Eye Drops for Dry Eye After LASIK." Journal of Refractive Surgery 22, no. 1 (January 1, 2006): 61–66. http://dx.doi.org/10.3928/1081-597x-20060101-13.

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Song, Yinyu, Lihua Fang, Ruirui Du, Luchao Lin, and Xingming Tao. "The corneal biomechanical changes after SMILE and LASIK refractive surgery were compared based on finite element analysis." E3S Web of Conferences 271 (2021): 03045. http://dx.doi.org/10.1051/e3sconf/202127103045.

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The three-dimensional (3D) finite element model of human eye was established, and the intraocular pressure (IOP) was loaded to simulate refractive surgery. The biomechanical properties of human cornea after SMILE and LASIK surgery were studied from the stress, strain and induced wavefront aberration. Our results showed that SMILE had less impact on the biomechanics, having less stress and strain changes than LASIK. However, the stress and strain of the cornea increased with the increase of the diopter and were concentrated in the central region. We also investigated the changes in wavefront aberrations of the cornea after surgery, and the results indicated that the defocus and vertical commotion were significantly affected by SMILE and LASIK surgery, while the remaining aberrations were approximately unchanged. In conclusion, both SMILE and LASIK sergury procedures changed the postoperative corneal biomechanics, but SMILE had less impact on the biomechanics of corneal.
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Kulikova, I. L., and N. V. Chapurin. "Long-term Outcomes of Femtosecond Laser-assisted Laser in situ Keratomileusis for Anisometropic Amblyopia in Children with Hyperopia." Ophthalmology in Russia 15, no. 2S (July 28, 2018): 46–51. http://dx.doi.org/10.18008/1816-5095-2018-2s-46-51.

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Objective: analysis of remote clinical functional results of femtolaser-assisted laser in situ keratomileusis (FS-LASIK) in children with hyperopia and anisometropic amblyopia.Patients and methods: 30 children aged 5–13 (7.9 ± 2.3) years were in the study. FS-LASIK refined technology surgery was rendered to all children under general anesthesia at amblyopic eye, previously they had no success of conservative treatment. Mean spherical equivalent of refraction (SE) of amblyopic eye was +5,08 ± 1.64 D in conditions of cycloplegia. Mean SE anisometropia was 3,42 ± 1.92 D, difference in refraction between eyes was statistically significant (pmu = p < 0,001) in all patients. There was 43.3% of severe amblyopia, 56.7% cases of moderate amblyopia. General period of control was 5 years.Results: In 5 years after FS-LASIK SE of operated eye was +1.02 ± 0.28 D, predictability of refractive effect within ±0.5 D was 47%, ±1.0 D was 77% of cases. All patients gained 1–5 lines, UDVA was 0,5 and higher in 61% of cases. There were 6.7% of cases with moderate amblyopia, mild –80%, and amblyopia absence –13.3 % of cases. SE anisometropia decreased 2,37 ± 1.17 and was 0,18 ± 1.05 D, difference between operated and fellow eye was minor, but statistically significant (pmu = p < 0,05). Trend to myopisation of fellow eye was revealed.Conclusion: remote clinical functional results of FS-LASIK in correction of hyperopic anisometropia in children show safety and efficacy of interference. Refractive surgery in children should be considered not as an independent method of treatment, but in complex with conservative methods of amblyopia treatment.
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Bikbova, Guzel, Toshiyuki Oshitari, Madoka Sakurai, Takayuki Baba, and Shuichi Yamamoto. "Macular Hole after Laser In Situ Keratomileusis in a 26-Year-Old Patient." Case Reports in Ophthalmological Medicine 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/739474.

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The purpose of this study is to describe the 26-year-old patient with developed macular hole after bilateral laser in situ keratomileusis (LASIK). A macular hole with sharp margins and irregular surface of surrounding retina appeared in the left eye of the female 26-year-old patient two months after LASIK for correction of myopia (followup of 6 months). Although the best corrected visual acuity (BCVA) after LASIK was 1.0, after the macular hole has developed BCVA became 0.5. After surgery, the final visual acuity recovered to 0.7. Macular hole may develop after LASIK for myopia correction due to unknown changes of vitreoretinal interface. Complete informed consent must be obtained from patients with high myopic eyes before LASIK.
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Abdolahian, Milad, Mohammad Ali Moalem, Mohammadreza Jahady Hoseiny, Farsad Noorizadeh, and Athar Zareei. "Keratorefractive Surgery Outcomes in Keratoconus Suspect Patients." Journal of Ophthalmology 2020 (December 2, 2020): 1–11. http://dx.doi.org/10.1155/2020/8823744.

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Purpose. To examine the outcomes of keratorefractive surgeries in keratoconus suspect patients. Methods. This study included 192 keratoconus suspects (351 eyes), treated with photorefractive keratectomy (PRK) (211 eyes), Lasik (96 eyes), and Femto-Lasik (44 eyes) surgeries in an eye clinic. The best spectacle-corrected visual acuity (BSCVA) and subjective refraction were evaluated preoperatively and postoperatively (three months and five years after the procedure). The Orbscan II topography system was also used preoperatively and five years after the procedure. Results. The patients’ mean age was 31.6 ± 5.49 years (range: 21–47 years) in the last follow-up. There was no significant difference between the preoperative and postoperative mean values of BSCVA in any of the surgical methods ( P = 0.49). The mean spherical equivalent, cylindrical power, corneal curvature, the thinnest corneal thickness, and the central corneal thickness decreased significantly in the last follow-up ( P < 0.001). Four patients (3.50%) in the PRK group and one patient (1.85%) in the Lasik group needed glasses in the last follow-up. Eleven cases of corneal ectasia were detected in the last follow-up (six eyes of four patients [2.84%] and five eyes of four patients [5.20%] in the PRK and Lasik groups, respectively). Conclusion. In the present study, the high risk of postoperative ectasia was detected in keratoconus suspects following PRK and Lasik surgeries. According to the results, it can be concluded that Femto-Lasik surgery provides better outcomes than Lasik and PRK. Overall, the surgical criteria are suggested to be evaluated case by case, and the patients must be followed up over time to assess the corneal topography and refraction stability.
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Chia, Tao Ming Thomas, and Hoon C. Jung. "Cataract Surgery following Sequential Myopic and Hyperopic LASIK." Case Reports in Ophthalmology 9, no. 2 (May 24, 2018): 264–68. http://dx.doi.org/10.1159/000488849.

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We report a case of patient dissatisfaction after sequential myopic and hyperopic LASIK in the same eye. We discuss the course of management for this patient involving eventual cataract extraction and intraocular lens (IOL) implantation with attention to the IOL power calculation method used.
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Mohammad, Najah Kadhum, Suzan Rattan, Ahmed Shaker Ali Al Wassiti, and Zaid Al-Attar. "Femtosecond Small Incision Lenticular Extraction in comparison to Femtosecond Laser In situ Keratomileusis Regarding Dry Eye Disease." Open Access Macedonian Journal of Medical Sciences 10, B (February 3, 2022): 668–73. http://dx.doi.org/10.3889/oamjms.2022.8040.

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Abstract Objective: Comparison of femtosecond small incision lenticule extraction (FS-SMILE) versus Femtosecond laser Insitu keratomileusis (FS-LASIK) regarding dry eye disease (DED) and corneal sensitivity (CS) after those refractive surgeries. Methods: A comparative prospective study conducted for a period of 2 years; from March 2017 until February, 2019. Enrolled patients were diagnosed with myopia. Fifty patients (100 eyes) were scheduled for bilateral FS-SMILE and the other 50 patients (100 eyes) had been scheduled for bilateral FS-LASIK. Both groups were followed for six months after surgery. The age, gender, and preoperative refraction for both groups were matched. Complete evaluation of dry eye disease had been performed for the intervals of one week pre-operatively, one and six months postoperatively. The evaluation included history of symptoms according to scoring systems, investigations and clinical examination. Results: One month postoperatively and in both groups, there was significant DED (P < .01), although the incidence was lower in femtosecond SMILE group, overall severity score (0-4): 0.3 ± 0.3 (FS-SMILE) vs. 1.4 ± 0.9 (LASIK). One month postoperatively, CS was lower in FS- LASIK more than FS-SMILE eyes (2.3 ± 2.2 vs 3.6 ± 1.8, respectively, P < .01) and then return to not statistically significant sensitivities at six-month duration. DED was negatively correlated with CS (P < 0.01). Conclusions: The FS-LASIK surgery had a more pronounced effect on the CS and DED compared with FS-SMILE, with higher incidence of DED postrefractive surgery.
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Olcay, Kenan, Akin Cakir, Sercan Koray Sagdic, Eyup Duzgun, and Yildiray Yildirim. "Bilateral Iris Atrophy after the Femtosecond Assisted Laser In Situ Keratomileusis Surgery." Case Reports in Ophthalmological Medicine 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/127806.

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Purpose. To report an unknown complication of laser in situ keratomileusis (LASIK) surgery.Case Presentation. A 28-year-old female presented with photophobia and glare to our eye service. She stated in her medical history that she had undergone femtosecond assisted LASIK surgery in both eyes 15 months ago and her symptoms started just after this surgery. On admission, her best-corrected visual acuity was 10/10 in both eyes. She had mydriatic pupils with no direct light reflex. Examination of the anterior segment revealed bilateral iris atrophy projecting within the LASIK ablation zone and a transillumination defect was remarkable on the slit lamp examination.Conclusion. We hypothesized that this condition may have been caused by the abnormally increased IOP that resulted in ischemia in the iris vascular plexus during the suction process of surgery.
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31

Miret, Juan J., Ester Rojas, Vicente J. Camps, Celia Garcia, Maria T. Caballero, Begoña Martín, and Enrique Chipont. "Understanding the Real Effect of the High-Order Aberrations after Myopic Femto-Lasik." Optics 3, no. 4 (October 9, 2022): 384–99. http://dx.doi.org/10.3390/opt3040033.

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In this work we try to understand the real effect of increase in aberrations after Femto-LASIK surgery on the patient’s final visual quality, specifically when the visual acuity measurement is considered. A clinical study with 37 eyes of 20 patients that underwent myopic Femto-LASIK surgery and different personalized eye model simulations were carried out. In clinical study, correlations between pre- and postoperative parameters with visual acuity were analysed. Eye simulations (based on real data) provided simulations of vision quality before and after surgery. Our main results showed a significant increase in aberrations was obtained after surgery; however, no differences were found between the preoperative corrected distance visual acuity (CDVA) and the postoperative uncorrected distance visual acuity (UDVA). This absence of differences in visual quality could be explained by performing different simulations on three eyes that would cover most of the possible clinical situations. Simulations were implemented considering a pupil size of 2.5 mm and the personalized data of each patient. Results showed that final visual acuity (VA) change are determined by the final high-order aberrations (HOAS) and their increase after surgery but measured under photopic conditions. In conclusion, customized analysis of higher-order aberrations in scotopic pupils better predicts patient visual acuity after Lasik surgery.
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Shishkin, S. A., N. V. Samokhvalov, I. V. Dutchin, and E. L. Sorokin. "Frequency patients with hyperopia in refractive surgery department in ophthalmic surgery clinic." Modern technologies in ophtalmology, no. 1 (May 29, 2021): 44–46. http://dx.doi.org/10.25276/2312-4911-2021-1-44-46.

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Purpose. Determination of proportion patients with hyperopia in refractive surgery department of ophthalmic surgery clinic, analysis of degree of their hyperopia, morphometric parameters of anterior segment of the eye. Material and methods. The proportion of patients with hyperopia who were operated in the refractive surgery department of the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution in 2019 were assess. On limited sample of these patients, a quantitative assessment of degree of hyperopia was carried out, and morphometric parameters of the anterior segment of the eyes were studied. Results. In 2019, 141 patients with hyperopia were operated (282 operations), which amounted to 11.3% of the total number of patients in the department. The majority of patients had a moderate degree of hyperopia (55.3%). In 47.5% of eyes, hyperopia was combined with astigmatism up to 4 diopters. Conclusion. Femto LASIK technology made it possible to achieve maximum uncorrected visual acuity in 52% of patients with hyperopia in the study group. Modern capabilities of refractive surgery are capable of providing high functional results in patients with varying degrees of hyperopia. Key words:refractive errors, hyperopia, refractive surgery, Femto LASIK, age groups.
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Abdelazeem, Khaled, Mohamed A. Nassr, Hazem Abdelmotaal, Ehab Wasfi, and Dalia Mohamed El-Sebaity. "Flap Sliding Technique for Managing Flap Striae following Laser In Situ Keratomileusis." Journal of Ophthalmology 2020 (February 25, 2020): 1–6. http://dx.doi.org/10.1155/2020/5614327.

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Purpose. To assess the efficacy and safety of a simple, noninvasive, “flap-sliding” technique for managing flap striae following laser in situ keratomileusis (LASIK). Methods. This prospective, interventional study included eyes with post-LASIK flap striae. All eyes underwent flap sliding 1-2 days after surgery. Following flap edge epithelialisation, a cellulose sponge was used to gently slide the flap perpendicular to the striae direction. This technique allows for flap striae treatment without flap lifting, avoiding any associated lifting complications. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and refractive error were monitored one day after the flap-sliding procedure. Results. Fifteen eyes (15 patients) with post-LASIK flap striae were managed using the flap-sliding technique. The procedure did not successfully relocate the flap striae in 1 eye, and flap elevation and floating (using a balanced salt solution) were required. Therefore, 14 eyes were included in post-flap-sliding analyses. The UDVA improved in all patients the first day after the flap-sliding procedure was performed, with 11 of 14 eyes (78.57%) reaching an UDVA of 20/25 or better. Complications following flap sliding occurred in 2 eyes (14.29%). One eye had intraoperative epithelial abrasion, and 1 eye had residual postoperative striae outside of the optical zone. Conclusion. The flap-sliding technique is a simple, noninvasive, efficient, and safe technique for managing post-LASIK flap striae that develop after epithelial healing in the early post-LASIK period. This trial is registered with NCT04055337.
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Sim, Ha Eun, Min Ji Kang, Jee Hye Lee, Seung Hwa Baik, Sun Young Kim, Seong Woo Lee, and Je Hyung Hwang. "Scheimpflug Topography Oriented Adequate Repositioning of a Misaligned Free Flap after Laser in situ Keratomileusis." Case Reports in Ophthalmology 12, no. 3 (November 8, 2021): 889–93. http://dx.doi.org/10.1159/000519052.

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This report describes a case of Scheimpflug topography oriented adequate repositioning of a misaligned thick free flap after laser in situ keratomileusis (LASIK). A 24-year-old patient consulted for irregular astigmatism and disoriented free right eye flap. The patient previously underwent binocular LASIK at a private clinic. During the right eye surgery, the flap was repositioned after laser ablation due to the free flap. The free flap was not repositioned to its original configuration due to insufficient preoperative corneal marking. On examination, the uncorrected visual acuity was 0.4, and refractive power was +2.00 Dsph with −4.25 Dcyl axis 66 in the right eye. Scheimpflug topography revealed irregular right eye astigmatism. The sagittal curvature of topography showed a 40° counterclockwise misalignment of the steep axis of the cornea. The free flap was repositioned by 40° clockwise rotation. After this, the refractive corneal power improved to −1.00 Dsph with −1.00 Dcyl Axis 19 in the right eye. The uncorrected and best-corrected visual acuity improved to 20/30 and 20/25 (x − 0.25Dsph −1.25 Dcyl A20), respectively. This is the first report on free flap repositioning using Scheimpflug topography. As proper flap positioning was compromised because of the free LASIK flap with no preoperative corneal marking, the flap was effectively repositioned using Scheimpflug topography.
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35

Trubilin, V. N., E. G. Poluninа, V. V. Kurenkov, E. A. Kasparova, A. V. Trubilin, Yu V. Evstigneeva, and Yu M. Hazime. "The Role of Anamnesis in Modern Ophthalmic Practice: a Clinical Case." Ophthalmology in Russia 20, no. 1 (April 6, 2023): 172–79. http://dx.doi.org/10.18008/1816-5095-2023-1-172-179.

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Eyes’ dryness continues to be the most frequent complication after LASIK. As a rule, it disappear in the vast majority of patients during the first year after surgery. The conducted studies indicate that complaints of eyes’ dryness in the preoperative period significantly increase the risk of developing a severe form of dry eye syndrome in the postoperative period, especially in middle-aged women (45–59 years) and older. The clinical case presented in this article indicates the development of a severe form of dry eye syndrome after LASIK in a middle-aged patient receiving hormone replacement therapy for menopause, complaining of a feeling of dryness and discomfort in the eyes in the preoperative period, with intolerance to contact lenses and taking antidepressants in the absence of signs of severe dry eye in the preoperative period. Consequently, surgical intervention led to the development of the mentioned above condition. It is confirmed by the literature data indicating that the above factors can cause the development of a severe form of dry eye syndrome after LASIK. Taking into account the fact that tear production tests do not always correlate with the intensity of complaints of dryness, burning sensation, pain in the eyes, the most important component at the stage of deciding on the feasibility of refractive surgery in a particular patient is the collection of anamnesis and clinical picture. When preparing patients with a history of dry eye syndrome for refractive surgery, it is necessary to inform them that they have a significantly increased risk of developing dry eye syndrome. It may persist in the long-term postoperative period, and possibly go into a chronic form. Candidates for refractive surgery in the presence of complaints characteristic of dry eye syndrome can only be those patients who respond well to therapy aimed at relieving these symptoms in the preoperative period. Taking into account the multicomponent nature of pain in dry eye syndrome — nociceptive pain, which is formed at the stage of receptor irritation in the corneal tissue, and neuropathic pain that occurs with the participation of the peripheral and central nervous system, a comprehensive approach is needed in the treatment of dry eye syndrome.
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36

Agca, Alper, Engin Bilge Ozgurhan, Yusuf Yildirim, Kadir Ilker Cankaya, Nimet Burcu Guleryuz, Zeynep Alkin, Abdullah Ozkaya, Ahmet Demirok, and Omer Faruk Yilmaz. "Corneal Backscatter Analysis by In Vivo Confocal Microscopy: Fellow Eye Comparison of Small Incision Lenticule Extraction and Femtosecond Laser-Assisted LASIK." Journal of Ophthalmology 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/265012.

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Purpose. To evaluate and compare corneal backscatter from anterior stroma between small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (femto-LASIK).Methods. A cohort of 60 eyes of 30 patients was randomized to receive SMILE in one eye and femto-LASIK in the fellow eye. In vivo confocal microscopy was performed at 1 week and 1, 3, and 6 months after surgery. The main outcome measurements were maximum backscattered intensity and the depth from which it was measured, the backscattered light intensity 30 μm below Bowman’s membrane at the flap interface and 150 μm below the superficial epithelium, and the number of refractive particles at the flap interface.Results. The mean backscattered light intensity (LI) at all measured depths and the maximum backscattered LI were higher in the SMILE group than the femto-LASIK group at all postoperative visits. LI differences at 1 week and 1- and 3-month visits were statistically significant (P<0,05). LI differences at 6 months were not statistically significant. There was no difference in the number of refractive particles at the flap interface between the groups at any visit.Conclusions. SMILE results in increased backscattered LI in the anterior stroma when compared with femto-LASIK were evaluated.
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37

Bonita Asyigah and Ani Ismail. "Accommodation Amplitude Before and After Laser In Situ Keratomiletus (LASIK) In Myopic Patients." Sriwijaya Journal of Ophthalmology 3, no. 1 (June 20, 2020): 1–18. http://dx.doi.org/10.37275/sjo.v3i1.43.

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ABSTRACT Introductions: Laser in situ Keratomileusis (LASIK) is the most common refractive surgery to treat myopia. One of the most common complain after this procedure is blurry near- vision. Objectives: To evaluate the role of accommodation amplitude (AA) in myopic patients before and after LASIK and its effect to blurry near-vision in myopic patients after LASIK Methods: Patients with myopia who underwent LASIK procedure in Sriwijaya Eye Center Hospital from January to February 2018 studied prospectively. AA was assessed before and after LASIK with 1 day, 1 week and 1 month. Myopia degree, intraocular pressure (IOP), age, gender, ablation and corneal profile were also assessed. Results: A total 52 eyes from 32 patients were included. Visual acuity (VA) of all sample were significantly improve in 1 day after LASIK (p 0,001). Mean AA in myopic patients before LASIK 9,25 D and AA 1 day after LASIK were all significantly decrease into 9,00D (p 0,012) which can cause in blurry near- vision after LASIK. In 1 month followed-up, mean AA is significantly improved into 11,00 D (p 0,000) with no complain. Other factor that affect the changing AA were corneal cell density (CD), IOP and AA before LASIK. Conclusions: There is significant AA difference in myopic patients before and after LASIK. Blurry near-vision after LASIK is caused by AA adaptation mechanism after LASIK.
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Teus, M. A., C. Arruabarrena, J. L. Hernández-Verdejo, R. Cañones, and D. G. Mikropoulos. "Ocular residual astigmatism’s effect on high myopic astigmatism LASIK surgery." Eye 28, no. 8 (June 27, 2014): 1014–19. http://dx.doi.org/10.1038/eye.2014.133.

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Zhao, Li-Quan, Liang-Mao Li, Jun Liu, and Peng Li. "Bandage Contact Lens Application Reduces Fibrotic Wound Healing of Flap Margins after FS-LASIK: A Prospective Randomized Clinical Trial." Journal of Ophthalmology 2019 (January 10, 2019): 1–10. http://dx.doi.org/10.1155/2019/3074659.

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Purpose. To assess the efficacy of applying bandage contact lens (BCL) in reducing the fibrotic healing response of flap margins following femtosecond laser in situ keratomileusis (FS-LASIK).Methods. In this prospective, randomized, interventional, observer-masked trial, 41 patients (82 eyes) with myopia and/or myopic astigmatism were scheduled to undergo FS-LASIK. After surgery, patients were fitted with a BCL in one eye (BCL eyes,n=41) but not in the contralateral eye (control eyes,n=41), following randomized allocation of the BCL to the left or right eye of each patient. The BCL was left in place overnight and removed the following morning. All eyes subsequently received standardized postoperative treatments. Patients were followed up for 6 months. We evaluated patients’ self-reported postoperative symptom scores for pain, photophobia, tearing, and foreign-body sensation. At 6 months after surgery, we examined the corneal flap margin and adjacent regions, and photographed them using slit-lamp biomicroscopy, to subjectively evaluate the wound healing response.Results. Postoperative pain and photophobia were milder in the BCL group than in the control group (P=0.041andP=0.003, respectively), but patients felt more foreign-body sensation in the eye with a BCL than in the control eye (P=0.001). There was no significant difference in tearing score between BCL eyes and control eyes (P=0.118). Regarding the fibrotic healing response of the flap margin, control eyes showed a wide, bright peripheral circumferential band with a spiculated edge and high reflectivity; conversely, BCL eyes showed a markedly narrower and smoother peripheral circumferential band, with a less spiculated edge and lower reflectivity (P<0.001).Conclusion. Patients felt less discomfort in eyes treated with a BCL after FS-LASIK than in control eyes. BCL-treated eyes also had a less intense wound healing response at the flap margins than control eyes in some of patients. BCLs may merit consideration as a treatment option after FS-LASIK for special patients. This trial is registered withChiCTR1800016579.
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Crouzier, David, Vincent Dabouis, Edgar Gentilhomme, Rodolphe Vignal, Fréderic Bourbon, Florence Fauvelle, and Jean-Claude Debouzy. "Chronic Electromagnetic Exposure at Occupational Safety Level Does Not Affect the Metabolic Profile nor Cornea Healing after LASIK Surgery." Journal of Ophthalmology 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/762364.

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LASIK eye surgery has become a very common practice for myopic people, especially those in the military. Sometimes undertaken by people who need to keep a specific medical aptitude, this surgery could be performed in secret from the hierarchy and from the institute medical staff. However, even though the eyes have been previously described as one of the most sensitive organs to electromagnetic fields in the human body, no data exist on the potential deleterious effects of electromagnetic fields on the healing eye. The consequences of chronic long-lasting radar exposures at power density, in accordance with the occupational safety standards (9.71 GHz, 50 W/m2), were investigated on cornea healing. The metabolic and clinical statuses after experimental LASIK keratotomy were assessed on the different eye segments in a New Zealand rabbit model. The analysis methods were performed after 5 months of exposure (1 hour/day, 3 times/week). Neither clinical or histological examinations, nor experimental data, such as light scattering,1H-NMR HRMAS metabolomics,13C-NMR spectra of lipidic extracts, and antioxidant status, evidenced significant modifications. It was concluded that withdrawing the medical aptitude of people working in electromagnetic field environments (i.e., radar operators in the navy) after eye surgery was not justified.
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Bauer, Svetlana, Ludmila Venatovskaya, Andrey Kachanov, and Vladimir Kornikov. "Mathematical models of laser correction of myopia by LASIK, SMILE and PRK." Russian Journal of Biomechanics 25, no. 4 (December 30, 2021): 317–22. http://dx.doi.org/10.15593/rjbiomech/2021.4.02.

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The stress-strain state of the human eye, which cornea in its apexis is weakened after myopia surgical correction, is studied. The elastic system “corneasclera” is presented as two joint transversely isotropic spherical segments with nonuniform thickness, different radii of curvature and biomechanical properties. The cornea is modeled as multilayer shell. The simulated eye shell is filled with an incompressible fluid. Mathematical models of three different laser vision correction surgeries: small incision lenticule extraction (SMILE), laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK), are developed in the engineering simulation software ANSYS Inc. The diameter and thickness of the lenticular in SMILE, the diameter of the ablation zone and the maximum thickness (depth) of the corneal ablation in LASIK and PRK define optical surgery areas and are considered as comparable parameters. Finite element simulation shows that after LASIK vision correction the apex of the cornea has a greater displacement and the stress increase greater in the stroma than after SMILE and PRK. The influence of the multilayer structure of the cornea and elastic characteristics of the sclera on the biomechanics of the eye as a result of vision correction is shown.
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Chhadva, Priyanka, Florence Cabot, Anat Galor, and Sonia H. Yoo. "Long-Term Outcomes of Radial Keratotomy, Laser In Situ Keratomileusis, and Astigmatic Keratotomy Performed Consecutively over a Period of 21 Years." Case Reports in Ophthalmological Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/592495.

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Purpose. To describe a case of 3 refractive procedures performed in one eye over 2 decades.Methods. Case report.Results. A 41-year-old patient presented for refractive surgery evaluation. His ocular history includes bilateral radial keratotomy performed 21 years ago for moderate myopia: spherical equivalence of −4.25 D bilaterally. Postoperative uncorrected visual acuity (UCVA) was 20/30; however, over time he developed a hyperopic shift and UCVA decreased to 20/40 in the right eye. Thus, laser-assisted in situ keratomileusis (LASIK) was performed at an outside institution 6.5 years later, and the patient had initial improvement of UCVA to 20/25. Due to a change in refractive error, the patient underwent uneventful astigmatic keratotomy 13 years after LASIK in the right eye, and 1.5 years after surgery best-corrected visual acuity was 20/25 with manifest refraction of −1.00+5.50×134°. Conclusion. We report the outcomes and natural refractive progression in a patient who underwent three corneal refractive procedures over two decades. This case underlines the difficulties of long-term management of post-RK hyperopia and astigmatism.
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Kuleshova, N. A., O. V. Kolenko, and E. L. Sorokin. "Features of diagnosing glaucoma in myopic eyes in the long term after keratorefractive surgery (clinical case)." Modern technologies in ophtalmology, no. 4 (September 29, 2023): 60–65. http://dx.doi.org/10.25276/2312-4911-2023-4-60-65.

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Purpose. Demonstration of a clinical case of diagnosis and dynamic observation of glaucoma in a patient after LASIK. Material and methods. Patient A., 58 years old. Complaints about decreasing in vision of the right eye into the distance during the last year. In 2004, LASIK was performed for moderate myopia with astigmatism. In 2018, for the first time, asymmetry of the parameters of the optic nerve head (the ratio of the maximum excavation size to the diameter of the disk (E/D)) was revealed for the first time: up to 0.7 in the right eye; on the left eye – up to 0.5. At the same time, the level of intraocular pressure (IOP) according to Maklakov was 22 mm Hg. Installations of prostaglandin analogues (APG) (0.005% solution of latanoprost) once are recommended. In subsequent years, the patient was on the «D» register at the place of residence, the level of IOP according to Maklakov varied from 18 to 20 mm Hg. After 4 years, the level of IOP according to Maklakov (on the previous hypotensive regimen): OD – 18 mm Hg; OS – 21 mm Hg. Ophthalmoscopically OD: E/D – 0.85–0.9; on OS: E/D – 0.9 with a breakthrough of the neuroretinal rim from below. SAP: OD – with absolute scotoma in the Bjerrum’s zone 5–15° from the fixation point, OS – blind spot expansion. Based on this, the diagnosis was formulated: primary open-angle glaucoma III A of the right eye, II A of the left eye. Results. Selective laser trabeculoplasty was performed. But due to the lack of complete stabilization of the IOP level, the hypotensive regimen was strengthened in the form of installations of APG and alpha-agonists. Despite this, the progression of glaucoma optic neuropathy was noted, and a decision was made to perform antiglaucoma surgery. Conclusion. Despite Maklakov’s IOP levels within the average statistical norm, in patients after LASIK, it is important to assess carefully the condition of the structures of the optic nerve head. Keywords: keratorefractive operations, myopia, glaucoma, ophthalmotonometry
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Afsharpaiman, Shahla, Musa Zare, Masoud Yasemi, Tannaz Jamialahmadi, and Amirhossein Sahebkar. "The Prevalence of Infectious Keratitis after Keratorefractive Surgery: A Systematic Review and Meta-Analysis Study." Journal of Ophthalmology 2020 (July 28, 2020): 1–8. http://dx.doi.org/10.1155/2020/6329321.

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Background. The keratorefractive surgeries (KRS) are one of the most common ocular surgeries. One of the dangerous complications of these surgeries is infectious keratitis (IK), which is the second cause of blindness after cataract surgery. The purpose of this study was to estimate the prevalence of IK after KRS in different parts of the world. Methods. In order to obtain relevant studies, all national and international databases including IranMedex, SID, Magiran, IranDoc, Medlib, ScienceDirect, PubMed, Scopus, Cochrane, Embase, Web of Science, and Google Scholar were searched using standard keywords. Results. IK prevalence after KRS was 0.000496% (0.000145% for the left eye and 0.000149% for the right eye). IK prevalence after KRS in the United States, Europe, and Asia was 0.000667%, 0.000473%, and 0.000045%, respectively, in all of which the common microorganisms were Staphylococci. Meta-regression showed no significant association between IK after KRS and either sample size or publication year of the studies. IK prevalence after KRS in the right eye was more than that in the left one. Also, the probability of IK incidence after LASIK surgery was more than PRK and LASEK. In the evaluation of continents, IK after KRS in the United States was more frequent compared with Europe and Asia. Conclusions. This study provided data as to the overall prevalence of IK following KRS and its variations according to the types of eye, surgery, pathogenic microorganism, and geographical location.
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Gogri, Pratik Yeshwant, Pravin Krishna Vaddavalli, and Sushank Ashok Bhalerao. "Central toxic keratopathy leading to epithelial ingrowth following femtosecond LASIK." BMJ Case Reports 17, no. 5 (May 2024): e256508. http://dx.doi.org/10.1136/bcr-2023-256508.

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We report a case of a woman in her 30s who underwent femtosecond LASIK (laser-assisted in situ keratomileusis) in both eyes to correct her simple myopic astigmatism. After the surgery, both eyes developed diffuse lamellar keratitis, and intensive topical steroids were initiated to control the same. Subsequently, central toxic keratopathy (CTK) developed bilaterally. Three weeks after the surgery, the right eye showed signs of progressive epithelial ingrowth involving the pupillary area. Surgical intervention in the form of flap relift followed by debridement of the epithelial cells and an alcohol interface wash were performed to treat the same. This is the first report of an epithelial ingrowth following CTK after femtosecond LASIK.
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46

Pavlenko, T. S., and E. V. Tur. "A case report of excimerlaser correction of high degree mixed astigmatism." Reflection, no. 1 (June 7, 2022): 113–17. http://dx.doi.org/10.25276/2686-6986-2022-1-113-117.

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Aim. To describe a clinical case of excimer laser correction of high degree mixed astigmatism with high visual results and a history of stable postoperative refraction. Case report. A 22-year-old patient with high degree mixed astigmatism in the right eye and moderate myopia with compound moderate myopic astigmatism in the left eye was treated with LASIK technology using the Aspheric ablation program. High visual functions were obtained in both eyes (1.0) and the results were stable during three years of follow-up. Conclusions. Modern technologies of refractive surgery provide high functional results and safety in patients with high degrees of astigmatism, improve the quality of life and can be the method of choice when determining the method of astigmatism correction. Key words: excimer laser correction; astigmatism; LASIK.
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47

Pradhan, Asik, Kishore Raj Pradhan, Gauri Shankar Shrestha, Purushottam Dhunganga, and Raju Kaiti. "Contrast sensitivity before and after small incision lenticule extraction and femtosecond laser in situ keratomileusis." Asian Journal of Ophthalmology 16, no. 4 (November 23, 2019): 284–92. http://dx.doi.org/10.35119/asjoo.v16i4.417.

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Introduction: Contrast sensitivity function after laser ablation of the cornea in refractive surgery is an important tool for measuring quality of visual function. The effect of small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK) on visual function can be compared by measuring spatial contrast sensitivity. Purpose: This study was to compare contrast sensitivity function in patients undergoing refractive surgery for myopia at Tilganga Institute of Ophthalmology. Methods: In a retrospective study, 15 subjects who underwent refractive surgeries comprising 9 cases of SMILE and 6 cases of FS-LASIK at Tilganga Eye Hospital were enrolled in the study. A major assessment included best corrected monocular contrast sensitivity with functional vision analyzer at spatial frequencies of 1.5, 3, 6, 12, and 18 cycles/deg in photopic condition (85 cd/m2) before, 3 months, and 1 year after the surgery. The average functional acuity contrast test scores for each spatial frequency were recorded. Differences between preoperative and postoperative contrast sensitivity at each spatial frequency were analyzed through parametric paired Student’s t-test. Results: Contrast sensitivity of postoperative FS-LASIK and SMILE did not differ from preoperative values at a photopic level. However, at high spatial frequency (12 and 18 cycles/deg), contrast sensitivity function improved significantly (p < 0.05) in eyes after FS-LASIK. Eyes after SMILE surgery did not show any reduction in contrast sensitivity at all the spatial frequencies. Conclusion: Under photopic conditions, the contrast sensitivity function is unaffected by SMILE or FS-LASIK.
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Fang, Zhi, and Wei Han. "Small incision lenticule extraction and femtosecond-assisted laser in situ keratomileusis in patients with deep corneal opacity: case series." International Journal of Ophthalmology 16, no. 2 (February 18, 2023): 301–8. http://dx.doi.org/10.18240/ijo.2023.02.19.

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AIM: To report the safety, efficacy, and accuracy of small-incision lenticule extraction (SMILE) or femtosecond-assisted laser in situ keratomileusis (FS-LASIK) for the correction of myopia or myopic astigmatism in patients with deep corneal opacity denoted by anterior segment optical coherence tomography (AS-OCT). METHODS: Four patients with monocular corneal opacity (3 due to mechanical injury, 1 due to a firecracker wound) were recruited and treated with refractive surgery (3 for SMILE, 1 for FS-LASIK combined with limbal relaxing incision (LRI). Preoperative ocular manifestations, surgical details, postoperative visual outcomes, corneal opacity parameters, and corneal topography were analyzed. RESULTS: Preoperatively, spherical diopter ranged from -3.0 D to -4.75 D with cylinder ranging from -0.75 to -5.0 D, and corrected distance visual acuity (CDVA) ranging from 20/25 to 20/20. One eye’s corneal opacity was located in the central zone and three were in the mid-peripheral optical zone. Three patients underwent uneventful SMILE in both eyes, whilst one patient underwent FS-LASIK for high astigmatism in both eyes and LRI in the right eye. CDVA of the eye with corneal opacity ranged from 20/22 to 20/20 one to six weeks postoperatively. Two patients achieved better CDVA and no patients lost Snellen lines. The postoperative diopter was within ±0.75 D for all eyes. Significant edema existed above the corneal opacity in one eye and dissipated soon. No eccentric corneal topography or morphological anomaly of the corneal cap or flap was observed. CONCLUSION: The cases demonstrate that SMILE or FS-LASIK is safe and effective to treat myopic astigmatism combined with deep corneal opacity lesions after comprehensive preoperative evaluation and appropriate candidate selection. FS-LASIK combined with LRI is also sufficient for correcting high astigmatism due to corneal scarring.
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49

Md Rejab, Noor Shazana, Muhammad Emy Iekmal Bin Yusof, Mohd Radzi Hilmi, and Khairidzan Mohd Kamal. "Effects of artificial tears on keratocyte cell density after femtosecond laser in situ keratomileusis: a prospective, comparative, interventional, contralateral eye study." Medical hypothesis, discovery & innovation in optometry 4, no. 2 (June 22, 2023): 50–56. http://dx.doi.org/10.51329/mehdioptometry173.

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Background: Flap creation during laser refractive surgery restructures the anterior cornea, particularly the stroma, reducing the keratocyte cell density (KCD). This reduced density makes it challenging to completely regenerate to the presurgical phase. The aim of the present study was to investigate the effects of two types of artificial tear (AT) interventions on KCD up to 3 months after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) surgery. Methods: This prospective, double-blind, comparative, interventional, contralateral eye study recruited patients with myopia scheduled for FS-LASIK. Inclusion criteria were healthy individuals aged 19 – 25 years with moderate or high myopia, a maximum cylindrical error of - 1.25 diopters, and a maximum pupil size of 6.5 mm who had undergone FS-LASIK and completed 3 months of follow-up. Complete optometric and ophthalmologic examinations were performed. Bilateral simultaneous FS-LASIK surgery was performed using the same femtosecond laser platform as in the standard procedure. The Research Randomizer was used to determine the eye to be treated with Systane® Hydration (Alcon Laboratories, Inc., Fort Worth, TX, USA) or Systane® ULTRA (Alcon Laboratories, Inc., Fort Worth, TX, USA) AT. KCD was examined using real-time images obtained from in vivo confocal microscopy (Heidelberg Retina Tomograph 3 with the Rostock Cornea Module, HRT III RCM); Heidelberg Engineering GmbH, Heidelberg, Germany) at baseline and 1- and 3-month postoperative visits. Results: We included 60 eyes of 30 participants with a mean (standard deviation) age of 21.34 (1.85) years and a male-to-female ratio of 1:1 who completed 3-month post-FS-LASIK surgery follow-up. KCD did not differ significantly between the two groups at any visit (all P > 0.05); nevertheless, mean KCD was initially reduced up to 1 month postoperatively and then revealed a slight increase up to 3 months postoperatively in Systane® Hydration-treated eyes and continued to reduce in Systane® ULTRA-treated eyes. Intragroup comparisons revealed that the eyes treated with ATs experienced a significant reduction in KCD between the preoperative and 1-month postoperative visits and between the preoperative and 3-month postoperative visits (all P < 0.05). Treatment-related complications were not observed. Conclusions: Overall, KCD reduced up to 3 months post-FS-LASIK surgery. Both AT types exerted a comparable effect on postoperative KCD up to 3 months. Future studies with a more frequent administration of ATs, longer follow-up periods, and a control group are required before preliminary outcomes of the present study can be generalized.
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Balestrazzi, Angelo, Alessandra Balestrazzi, Maria Ilaria Giannico, Paolo Michieletto, and Emilio Balestrazzi. "Diagnosis, Clinical Trend, and Treatment of Diffuse Lamellar Keratitis after Femtosecond Laser-Assisted in situ Keratomileusis: A Case Report." Case Reports in Ophthalmology 9, no. 3 (November 14, 2018): 457–64. http://dx.doi.org/10.1159/000493338.

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We report a severe case of diffuse lamellar keratitis (DLK) following femtosecond laser-assisted in situ keratomileusis (femto-LASIK). A 25-year-old man was submitted to 150 kHz iFS® IntraLase-assisted LASIK in both eyes for compound myopic astigmatism. The day after surgery, clinical examination showed a diffuse whitish granular cell reaction particularly in the right eye. High-dose dexamethasone eyedrops with topical antibiotic and artificial tears were prescribed. Five days after surgery, a central corneal opacity with convergent striae was detected at biomicroscopy. The suspicion of DLK was confirmed. Additional therapy based on hyperosmolar ophthalmological solution, oral doxycycline, and topical 10% sodium citrate was prescribed. Treatment was continued and tapered for over 3 months. Improvement in corneal transparency were obtained 2 weeks after the systemic therapy had been started. Uncorrected visual acuity improved from 20/32 to 20/20 at 1-year follow-up. DLK represents an infrequent complication after femto-LASIK. It should resolve without sequelae if promptly diagnosed and treated, without necessity of corneal flap lifting.
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