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Journal articles on the topic 'Lassa Fever/epidemiology/transmission'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Sizikova, T. E., V. N. Lebedev, S. I. Syromyatnikova, and S. V. Borisevich. "LUJO HEMORRHAGIC FEVER." Problems of Virology, Russian journal 62, no. 4 (2017): 149–53. http://dx.doi.org/10.18821/0507-4088-2017-62-4-149-153.

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Lujo hemorrhagic fever (LHF) is a viral disease accompanied with fever, headache, vomiting, diarrhea, arthralgia, myalgia and numerous signs of hemorrhagic syndrome. LHF causes a clinical syndrome remarkably similar to Lassa hemorrhagic fever. The first case of LHF occurred in Johannesburg, South Africa, in 2008. There was a secondary transmission from the index patient to four healthcare workers. Four of the five patients died. The etiologic agent of LHF is Lujo virus (LUJV) belonging to Arenavirus genus of the Arenaviridae Family. Virus Lujo is the second pathogenic arenavirus, after Lassa v

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2

Akafa, Tensaba Andes, Artu Ishishen John, Gloria Omonefe Oladele, and Isaac John Umaru. "Persistent Threat of Lassa Fever in Nigeria: Epidemiology, Challenges, and Strategies for Effective Management." African Journal of Medicine, Surgery and Public Health Research 2, no. 2 (2025): 270–81. https://doi.org/10.58578/ajmsphr.v2i2.5517.

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Lassa fever is a viral hemorrhagic disease that poses a significant public health threat in Nigeria and West Africa. This review assesses the epidemiological trends, health impacts, and socioeconomic consequences of Lassa fever in Nigeria while proposing strategies for effective management and prevention. The natural reservoir of the Lassa virus, the multimammate rat (Mastomys natalensis), is prevalent in Nigerian households, facilitating transmission through direct contact with the rodents or their excreta, which often contaminates food. Consumption of these rats as a delicacy further exacerb

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Abdullahi, Idris Nasir, Abubakar Umar Anka, Peter Elisha Ghamba, Nkechi Blessing Onukegbe, Dele Ohinoyi Amadu, and Matthew Oluwafemi Salami. "Need for preventive and control measures for Lassa fever through the One Health strategic approach." Proceedings of Singapore Healthcare 29, no. 3 (2020): 190–94. http://dx.doi.org/10.1177/2010105820932616.

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Lassa virus (LASV) has increasingly been recognised as a significant public-health pathogen transmitted by rodents. LASV infection leads to life-threatening Lassa fever, which has high potential for severe morbidity and mortality. There have been several scientific efforts to understand the genomics and ecological epidemiology of Lassa. However, very limited studies have focused on the short- and long-term impacts of environmental factors, human behaviours and rodent activities on LASV transmission dynamics and control. Recently, a very plausible and ideal way to address the Lassa epidemic has

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4

Chinedu, Obasi, Mbah C. E. Godwin, Didigwu Ndidiamaka, and Offor Paschal. "Mathematical Treatment Model of Lassa Fever." Journal of Mathematical Sciences & Computational Mathematics 3, no. 2 (2022): 156–66. http://dx.doi.org/10.15864/jmscm.3202.

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We present and explore a novel mathematical treatment model of the epidemiology of Lassa Fever (LF). The model is a system of nonlinear ordinary differential equation model for rodent and human population. We analyzed the model to find the stability of the disease-free equilibrium and test which model parameters affect this stability most significantly. The purpose of this paper is to investigate the impact of treatment on the control of LF. The analysis revealed that treatment rate of humans will have a positive impact in reducing the burden of LF in the population. Our model predicts that tr

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5

Asogun, Danny, Bosede Arogundade, Faith Unuabonah, et al. "A Review of the Epidemiology of Lassa Fever in Nigeria." Microorganisms 13, no. 6 (2025): 1419. https://doi.org/10.3390/microorganisms13061419.

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Lassa fever, a viral hemorrhagic illness that first came into the limelight as a clinical entity in 1969 when it was discovered in Northern Nigeria, is now found in other West African countries such as Sierra Leone, Liberia, Guinea, Togo, and the Benin Republic. Over the years, the disease, which is primarily transmitted from contact with infected mastomys rodents to humans, has the capability of secondary human-to-human transmission with significant morbidity and mortality, especially in healthcare settings. The disease is typically characterized by seasonal outbreaks, which peak during the d

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6

Medugu, N., B. Adegboro, M. S. Babazhitsu, M. Kadiri, and E. A. Abanida. "A review of the recent advances on Lassa fever with special reference to molecular epidemiology and progress in vaccine development." African Journal of Clinical and Experimental Microbiology 24, no. 2 (2023): 130–46. http://dx.doi.org/10.4314/ajcem.v24i2.3.

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Lassa fever, a viral hemorrhagic fever caused by the Lassa virus (LASV), is endemic in West Africa and is associated with high morbidity and mortality. At least three of the four proposed seven lineages of LASV are found in Nigeria, where the multimammate rat, Mastomys natalensis, serves as the primary reservoir. Endemic countries report approximately 200,000 infections and 5,000 deaths annually, with Nigeria experiencing thousands of infections and hundreds of deaths including healthcare workers. The aim of this review is to provide scientific information for better understanding of the evolu

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7

Ter, Meulen J., I. Lukashevich, K. Sidibe, et al. "Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea." American Journal of Tropical Medicine and Hygiene 55, no. 6 (1996): 661–66. https://doi.org/10.5281/zenodo.13535216.

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(Uploaded by Plazi for the Bat Literature Project) In this population-based study, we correlated possible risk factors for rodent-to-human transmission of Lassa virus with markers of Lassa fever in two different regions of the Republic of Guinea (Prefectures of Pita and Gueckedou). Antibody prevalence was 2.6% (6 of 232) in Pita compared with 14.0% (105 of 751) in Gueckedou, with up to 35.0% seropositivity in selected villages of the higher prevalence area. We observed three major risk factors in Gueckedou favoring Lassa virus transmission: rodent infestation was much higher, food was more oft

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8

Ter, Meulen J., I. Lukashevich, K. Sidibe, et al. "Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea." American Journal of Tropical Medicine and Hygiene 55, no. 6 (1996): 661–66. https://doi.org/10.5281/zenodo.13535216.

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(Uploaded by Plazi for the Bat Literature Project) In this population-based study, we correlated possible risk factors for rodent-to-human transmission of Lassa virus with markers of Lassa fever in two different regions of the Republic of Guinea (Prefectures of Pita and Gueckedou). Antibody prevalence was 2.6% (6 of 232) in Pita compared with 14.0% (105 of 751) in Gueckedou, with up to 35.0% seropositivity in selected villages of the higher prevalence area. We observed three major risk factors in Gueckedou favoring Lassa virus transmission: rodent infestation was much higher, food was more oft

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9

Efe, Ubogun Ogheneakpobor, Efeisi Oreva Edward, Adigwe Augustina Chinaza, Okobah Chidinma Emmanuella, and Ntugba Joy Chidinma. "Lassa Fever: A Mini Review of Clinical Features, Diagnosis and Treatment." Asian Journal of Research in Infectious Diseases 15, no. 8 (2024): 7–13. http://dx.doi.org/10.9734/ajrid/2024/v15i8363.

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Lassa virus (LASV) is an enveloped single stranded RNA virus that results in Lassa fever (LF). The causative organism belongs to the Arenavirus genus. Since it's initial diagnosis in 1969 in Lassa town Nigeria, numerous endemic outbreaks have occurred with spread to other regions in Africa and beyond. LF is transmitted via rodent to human and human-to-human transmissions, with rodents being the reservoir of infection. Risk factors for the disease include residing in an endemic area with poor sanitation and overcrowding, close contact with infected individuals and being a health care worker. Ab

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10

Besson, Marianne E., Michel Pépin, and Pierre-Alexandre Metral. "Lassa Fever: Critical Review and Prospects for Control." Tropical Medicine and Infectious Disease 9, no. 8 (2024): 178. http://dx.doi.org/10.3390/tropicalmed9080178.

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Lassa Fever is a deadly viral haemorrhagic disease, causing annually several hundreds of deaths in West Africa. This zoonotic disease is primarily transmitted to humans by rodents of the genus Mastomys, even though other rodents reportedly carry the Lassa virus, while secondary interhuman transmission accounts for approximately 20% of cases. Although this disease has been endemic in rural zones of Nigeria, Sierra Leone, Liberfia, and Guinea for hundreds of years, it is also characterised by epidemic outbreaks in the dry season, responsible for heavy death tolls. No licensed vaccine or satisfyi

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Kafetzopoulou, L. E., S. T. Pullan, P. Lemey, et al. "Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak." Science 363, no. 6422 (2019): 74–77. https://doi.org/10.5281/zenodo.13513787.

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(Uploaded by Plazi for the Bat Literature Project) Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission;

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Kafetzopoulou, L. E., S. T. Pullan, P. Lemey, et al. "Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak." Science 363, no. 6422 (2019): 74–77. https://doi.org/10.5281/zenodo.13513787.

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(Uploaded by Plazi for the Bat Literature Project) Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission;

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13

Kafetzopoulou, L. E., S. T. Pullan, P. Lemey, et al. "Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak." Science 363, no. 6422 (2019): 74–77. https://doi.org/10.5281/zenodo.13513787.

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(Uploaded by Plazi for the Bat Literature Project) Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission;

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14

Kafetzopoulou, L. E., S. T. Pullan, P. Lemey, et al. "Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak." Science 363, no. 6422 (2019): 74–77. https://doi.org/10.5281/zenodo.13513787.

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(Uploaded by Plazi for the Bat Literature Project) Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission;

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15

Kafetzopoulou, L. E., S. T. Pullan, P. Lemey, et al. "Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak." Science 363, no. 6422 (2019): 74–77. http://dx.doi.org/10.1126/science.aau9343.

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The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases, raising concerns over the emergence of a strain with increased transmission rate. To understand the molecular epidemiology of this upsurge, we performed, for the first time at the epicenter of an unfolding outbreak, metagenomic nanopore sequencing directly from patient samples, an approach dictated by the highly variable genome of the target pathogen. Genomic data and phylogenetic reconstructions were communicated immediately to Nigerian authorities and the World Health Organization to inform the public health

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16

Oshiokhayamhe, Iyevhobu Kenneth, Okparaku Sunday Onyemaechi, Asibor Ernest, Ken-Iyevhobu Benedicta Agumeile, Momoh Abdul-Razaq McSionel, and Momodu Kawthar Osilama. "Epidemiology and Comprehensive Review on the Myth and Facts of Lassa Fever Transmission." Asian Journal of Biological Sciences 17, no. 4 (2024): 720–29. http://dx.doi.org/10.3923/ajbs.2024.720.729.

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17

Arruda, Liã Bárbara, Hayley Beth Free, David Simons, et al. "Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions." PLOS Global Public Health 3, no. 11 (2023): e0002159. http://dx.doi.org/10.1371/journal.pgph.0002159.

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Lassa fever (LF) is a potentially lethal viral haemorrhagic infection of humans caused by Lassa mammarenavirus (LASV). It is an important endemic zoonotic disease in West Africa with growing evidence for increasing frequency and sizes of outbreaks. Phylogeographic and molecular epidemiology methods have projected expansion of the Lassa fever endemic zone in the context of future global change. The Natal multimammate mouse (Mastomys natalensis) is the predominant LASV reservoir, with few studies investigating the role of other animal species. To explore host sequencing biases, all LASV nucleoti

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18

Grahn, Anna, Andreas Bråve, Thomas Tolfvenstam, and Marie Studahl. "Absence of Nosocomial Transmission of Imported Lassa Fever during Use of Standard Barrier Nursing Methods." Emerging Infectious Diseases 24, no. 6 (2018): 978–87. http://dx.doi.org/10.3201/eid2406.172097.

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19

Kraft, Colleen S., Aneesh K. Mehta, Jay B. Varkey, et al. "Serosurvey on healthcare personnel caring for patients with Ebola virus disease and Lassa virus in the United States." Infection Control & Hospital Epidemiology 41, no. 4 (2020): 385–90. http://dx.doi.org/10.1017/ice.2019.349.

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AbstractObjective:Healthcare personnel (HCP) were recruited to provide serum samples, which were tested for antibodies against Ebola or Lassa virus to evaluate for asymptomatic seroconversion.Setting:From 2014 to 2016, 4 patients with Ebola virus disease (EVD) and 1 patient with Lassa fever (LF) were treated in the Serious Communicable Diseases Unit (SCDU) at Emory University Hospital. Strict infection control and clinical biosafety practices were implemented to prevent nosocomial transmission of EVD or LF to HCP.Participants:All personnel who entered the SCDU who were required to measure thei

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20

Mims, C. A. "The origin of major human infections and the crucial role of person-to-person spread." Epidemiology and Infection 106, no. 3 (1991): 423–33. http://dx.doi.org/10.1017/s0950268800067479.

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In discussions of the origin of new infectious diseases, prominence is usually given to dramatic infections acquired from animals (Lassa fever, Marburg and Ebola viruses) or from the environment (legionellosis). But these infections do not spread from human to human, and their impact on mankind can never be catastrophic. If a new infectious agent is to pose a major threat to the human species, it will need to kill tens or hundreds of millions of people over a short period of time (a few years), before vaccines and antimicrobial agents can be developed or effective blocks to transmission establ

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21

Anjorin, Abdul-Azeez, Ismail Odetokun, Oluwaseyi Ashaka, et al. "Critical appraisal of Monkeypox (Mpox) in Africa using scoping and systematic review methods." Proceedings of the Nigerian Academy of Science 17, no. 1 (2024): 22–53. http://dx.doi.org/10.57046/mjcj2507.

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Africa remains a battlefield for the emergence and re-emergence of deadly aetiologies including the Lassa fever virus from 1969, Monkey pox (mpox) virus from 1970, and Ebola virus from 1976 till date, among others. With the recent index case of mpox following rapid spread from Africa to different continents, a critical appraisal of the disease to x-ray its dynamics in Africa is warranted. This study integrated a mix of scoping and systematic reviews to converse the epidemiology and biosecurity/environmental issues from one health perspective. Our scoping review used major scientific databases

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Amoo, Olufemi Samuel, Joseph Shaibu, Olumuyiwa Salu, et al. "Comparative Assessment of Knowledge, Attitude/Practices and Prevention of Lassa fever among Community Dwellers and Contacts of Confirmed Patients in Endemic Areas of Ondo State, Nigeria." European Journal of Medical and Health Sciences 3, no. 4 (2021): 137–44. http://dx.doi.org/10.24018/ejmed.2021.3.4.962.

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Background: The current resurgence and transmission dynamics of Lassa fever (LF) within an endemic community in Nigeria calls for concern. Lassa fever virus is known to be transmitted from rodents to humans as well as from human to human. This study aims to compare the knowledge, attitude/practices and prevention of Community dwellers (CD) and Contacts of confirmed Lassa fever patients (CCP) with respect to LF in an endemic area in Nigeria. Methodology: This is a comparative cross-sectional study conducted between 2018 and 2019 during an outbreak of LF disease in Ondo State, Nigeria. A total o

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Ebenezer, Abdullahi, and Samuel Adesewa. "LASSA FEVER MITIGATION: COMBATTING AN EMERGING INFECTIOUS DISEASE THREAT." Global Journal of Medical and Pharmaceutical Sciences 02, no. 04 (2023): 01–07. http://dx.doi.org/10.55640/gjmps-abcd05.

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Lassa fever, caused by the Lassa virus, is a severe viral hemorrhagic fever with significant public health implications in West Africa. The disease poses a substantial burden on affected communities, leading to high morbidity and mortality rates. As an emerging infectious disease threat, Lassa fever presents challenges in terms of prevention, diagnosis, and control. This paper explores strategies for mitigating the risk of Lassa fever transmission and outbreak escalation. Key components of Lassa fever mitigation efforts include public health education, community engagement, surveillance and ea

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Olupitan, Oluwamuyiwa, Musilimu Taiwo, Kehinde Femi Adedapo, R. A. Adweinoye-Rabiu, and Segun Victor Oloja. "MATHEMATICAL MODEL OF LASSA FEVER TRANSMISSION DYNAMICS IN PREVALENT COMMUNITIES IN NIGERIA: THE CASE STUDY OF ONDO STATE." FUDMA JOURNAL OF SCIENCES 8, no. 5 (2024): 179–92. http://dx.doi.org/10.33003/fjs-2024-0805-2493.

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With the current waive of global health problems and resurgence of many disease around the world. Cholera, Yellow fever,SARS-CoV-2, Monkey pox and Lassa fever resurgence in some West African countries, with Ondo State recording highest number of Lassa fever case in Nigeria. Prompting Nigeria Centre for Disease Control (NCDC), Ondo State Primary Health (OSPH) expert and researchers begin ways to reduce transmission dynamics of Lassa Fever Disease (LFD). In this research, we developed and investigated using System of Ordinary Differential Equation (ODE) mathematical model of Lassa fever disease

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Maria-Lauretta, Orji, Anthony Ajayi Nnennaya, Marian Chika-Igwenyi Nneka, and Benson Onyire Nnamdi. "Tackling Lassa Virus Transmission in Endemic Regions: A Collective Responsibility." J Bas Med Clin Sci 1, no. 1 (2022): xv—xvii. https://doi.org/10.5281/zenodo.7471700.

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Lassa virus (LASV) is a single stranded RNA virus and belongs to the Arenaviridae family. It was first isolated in 1969 from a nurse who worked in a missionary hospital in a town, Lassa, in Borno state, northeastern Nigeria.[1] The virus is the aetiological agent of lassa fever; a haemorrhagic fever. It is found mainly in some countries of West Africa, such as Sierra Leone, Guinea, Liberia,  and Nigeria, although there is evidence to show that, there are pockets of LASV seen in other West African countries. [2-7] In Nigeria, Edo, Ondo and Ebonyi were the three most affected states until i

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Onah, Ifeanyi Sunday, and Obiora Cornelius Collins. "Dynamical System Analysis of a Lassa Fever Model with Varying Socioeconomic Classes." Journal of Applied Mathematics 2020 (November 18, 2020): 1–12. http://dx.doi.org/10.1155/2020/2601706.

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Lassa fever is an animal-borne acute viral illness caused by Lassa virus. It poses a serious health challenge around the world today, especially in West African countries like Ghana, Benin, Guinea, Liberia, Mali, Sierra Leone, and Nigeria. In this work, we formulate a multiple-patch Lassa fever model, where each patch denotes a socioeconomic class (SEC). Some of the important epidemiological features such as basic reproduction number of the model were determined and analysed accordingly. We further investigated how varying SECs affect the transmission dynamics of Lassa fever. We analysed the r

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Bakare, E. A., E. B. Are, O. E. Abolarin, S. A. Osanyinlusi, Benitho Ngwu, and Obiaderi N. Ubaka. "Mathematical Modelling and Analysis of Transmission Dynamics of Lassa Fever." Journal of Applied Mathematics 2020 (March 12, 2020): 1–18. http://dx.doi.org/10.1155/2020/6131708.

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Sub-Saharan Africa harbours the majority of the burden of Lassa fever. Clinical diseases, as well as high seroprevalence, have been documented in Nigeria, Sierra Leone, Liberia, Guinea, Ivory Coast, Ghana, Senegal, Upper Volta, Gambia, and Mali. Deaths from Lassa fever occur all year round but naturally peak during the dry season. Annually, the number of people infected is estimated at 100,000 to 300,000, with approximately 5,000 deaths. There have been some work done on the dynamics of Lassa fever disease transmission, but to the best of our knowledge, none has been able to capture the season

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Aloke, Sunday, and Patrick Okpara. "A Mathematical Model of Lassa Fever Transmission and Control in Ebonyi State, Nigeria." American Journal of Applied Mathematics 12, no. 2 (2024): 24–36. http://dx.doi.org/10.11648/j.ajam.20241202.11.

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Lassa virus is transmitted from rodents to humans, but it is not known whether humans can transmit Lassa fever to rats. The virus is thought to spread to humans through contact with contaminated food or surfaces. Other forms of infection include handling rodents for food (people often get rodent blood and urine on their hands) and bites. It can also spread through the use of contaminated medical equipment, such as reusing needles. The state variables of the Lassa Fever model equation is expressed as nonlinear ordinary differential equations in the technique of an initial value problem (IVP) ha

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Onah, Ifeanyi Sunday, Obiora Cornelius Collins, Praise-God Uchechukwu Madueme, and Godwin Christopher Ezike Mbah. "Dynamical System Analysis and Optimal Control Measures of Lassa Fever Disease Model." International Journal of Mathematics and Mathematical Sciences 2020 (April 29, 2020): 1–18. http://dx.doi.org/10.1155/2020/7923125.

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Lassa fever is an animal-borne acute viral illness caused by the Lassa virus. This disease is endemic in parts of West Africa including Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, and Nigeria. We formulate a mathematical model for Lassa fever disease transmission under the assumption of a homogeneously mixed population. We highlighted the basic factors influencing the transmission of Lassa fever and also determined and analyzed the important mathematical features of the model. We extended the model by introducing various control intervention measures, like external protection, isolation

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T.O., Oluyo, and Adejumo A.E. "Epidemiological Implications of Vertical Transmission and Nonlinear Treatment in Lassa fever: A Mathematical Study." International Journal of Mathematics and Computer Research 12, no. 11 (2024): 4597–612. https://doi.org/10.5281/zenodo.14244433.

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Lassa fever is a viral hemorrhagic disease primarily transmitted through contact with food or household items contaminated by urine or feces of infected rodents. The disease poses a significant health risk in endemic regions, yet the effect of vertical transmission and non-linear treatment on its spread has not been thoroughly explored. To address this, a mathematical model was constructed to assess the effect of vertical transmission and non-linear treatment in the transmission dynamics of Lassa fever. The model was validated through the theory of positivity and boundedness, ensuring that its

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Akinwumi Ayodeji Akinbodewa, Michael Olumide Gbala, Oluwole Olugbenga Ige, Olaseinde Bello, Bola Francis Akinkunmi, and Gabriel Fabusuyi. "Lassa fever: knowledge deficits among nurses and non-nurses at a tertiary hospital in Ondo, southwest Nigeria." Magna Scientia Advanced Biology and Pharmacy 9, no. 2 (2023): 014–23. http://dx.doi.org/10.30574/msabp.2023.9.2.0026.

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Introduction: Lassa fever is endemic to many African countries with knowledge deficit linked to increased exposure, morbidity and mortality among healthcare workers. Objectives: To assess knowledge deficit among nurses and non-nurses. Materials and methods: This was a descriptive, cross-sectional study conducted at the University of Medical Sciences Teaching Hospital, Ondo State, Nigeria. Results: There were 59 (48.8%) nurses and 62 (51.2%) non-nurses with a male to female ratio of 1:2.9. Their mean age was 34.2±8.0 years. Nurses and non-nurses performed well in 30 (62.5%) and 26 (54.2%) out o

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Omoloye, Musibau Abayomi, Akeem Olatoye Sanusi, and Iyabo Olamide Sanusi. "Modeling and Sensitivity Analysis of Dynamical Transmission of Lassa Fever." International Journal of Research and Review 8, no. 10 (2021): 531–39. http://dx.doi.org/10.52403/ijrr.20211067.

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Lassa fever is an acute viral disease which occurs across West Africa regions. In view of this a non-linear deterministic model was considered to study dynamics spread of Lassa fever. Existence and uniqueness of the model were determined and the basic reproduction number of the model was computed using next-generation matrix, and sensitivity analysis of the model was performed and shows that the most sensitive parameters to the dynamical spread of Lassa fever are human birth rate bH, followed by average number of female partners acquired by susceptible male c2, and transmission rate resulting

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Amodu, Samuel Andrew, and Stephen Oyedele Fapohunda. "Lassa fever and the Nigerian experience: a review." European Journal of Biological Research 9, no. 3 (2019): 155–64. https://doi.org/10.5281/zenodo.3382695.

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The occurrence, transmission and intervention strategies on the Lassa fever disease in Nigeria are presented. The Lassa virus is an enveloped, single stranded, bi-segmented RNA virus that belonging to the Arenaviridae family was first reported in 1969 from Lassa village, Borno State, Nigeria. The primary animal reservoir for the virus is the multi-mammate rat (<em>Mastomys natalensis</em>). It is transmitted to humans through the excreta of infected carrier, often via contaminated food and human-to-human transmission. The most common treatment intervention is ribavirin which carries out its fu

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Innocent, C. Eli, and C. Abanum Godspower. "Stabiizing The Steady State Solution of Lasser Fever: Problems and Prospect." International Journal of Multidisciplinary Research and Analysis 05, no. 01 (2022): 32–43. https://doi.org/10.47191/ijmra/v5-i1-05.

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The study of mathematical modeling of the stability analysis of Lassa fever was examined. A mathematical model for the spread and control of Lassa fever was formulated and analyzed. The model incorporates a control parameter, the use of condom to control human to human transmission through sexual contact with opposite sex. The disease free and endemic equilibrium states were analyzed.  

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Ehichioya, Deborah U., Meike Hass, Stephan Ölschläger, et al. "Lassa Fever, Nigeria, 2005–2008." Emerging Infectious Diseases 16, no. 6 (2010): 1040–41. http://dx.doi.org/10.3201/eid1606.100080.

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Patassi, Akouda Akessiwe, Dadja Essoya Landoh, Agballa Mebiny-Essoh Tchalla, et al. "Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016." Case Reports in Infectious Diseases 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/8242313.

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Background. Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo. Case Presentation. The two first Lassa fever cases occurred in two expatriate’s health professionals working in Togo for more than two years. The symptoms appeared among two health professionals of a clinic located in Oti district in the north of the country. The absence of clinical improvement after antimalarial treatment and the worsening of clinical symptoms led to the medical evacuation. The de

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Dalhat, Mahmood M., Adebola Olayinka, Martin M. Meremikwu, et al. "Epidemiological trends of Lassa fever in Nigeria, 2018–2021." PLOS ONE 17, no. 12 (2022): e0279467. http://dx.doi.org/10.1371/journal.pone.0279467.

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Background Lassa fever is a viral haemorrhagic fever endemic in Nigeria. Improved surveillance and testing capacity have revealed in an increased number of reported cases and apparent geographic spread of Lassa fever in Nigeria. We described the recent four-year trend of Lassa fever in Nigeria to improve understanding of its epidemiology and inform the design of appropriate interventions. Methods We analysed the national surveillance data on Lassa fever maintained by the Nigeria Centre for Diseases Control (NCDC) and described trends, sociodemographic, geographic distribution, and clinical out

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Umoke, MaryJoy, Prince Christian Ifeanachor Umoke, Chioma Adaora Nwalieji, et al. "Assessment of Knowledge and Sources of Information on Lassa Fever Infection Among the Undergraduate Students of Ebonyi State University, Nigeria." SAGE Open 11, no. 1 (2021): 215824402110063. http://dx.doi.org/10.1177/21582440211006382.

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Lassa fever is a zoonotic disease characterized by acute viral hemorrhagic fever, endemic in West Africa including Nigeria. The study assessed the knowledge and sources of information on Lassa fever infection among the undergraduate students of Ebonyi State University, Nigeria. This was a descriptive cross-sectional survey conducted among a sample of 389 students (18 years above). A self-administered questionnaire was used to collect data. Data were analyzed with SPSS (Version 20), and hypotheses were tested at p < .05 level of significance. Results showed that the majority of the students

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Egwu, Oguh Collins, Peter Kukeunim Ukeh, Zephaniah Jesse Cegbeyi, et al. "Lassa Fever Insights: Epidemiology, Metabolism, Pharmacokinetics of Ribavirin, Mechanisms against Arenaviruses and its Novel Application in the Future." Asian Journal of Research in Infectious Diseases 15, no. 12 (2024): 32–54. http://dx.doi.org/10.9734/ajrid/2024/v15i12399.

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Lassa fever is an acute viral hemorrhagic fever illness caused by Lassa virus which is zoonotics, or animal-borne. The virus is a member of the arena virus family, which is an RNA single-stranded virus. Ribavirin therapy is use for treatment and the antiviral abilities of ribavirin have been explained by five different mechanisms. These include both direct (interference with RNA capping, polymerase inhibition, lethal mutagenesis) and indirect mechanisms (Inhibition of inosine monophosphate dehydrogenase and immunomodulatory effects). Ribavirin was the first synthetic nucleoside to display broa

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Oniyangi, Shuaib Olanrewaju, Rachael Omoniyepe Oladosu, and AbdulQudus Tosin Jamiu. "Knowledge and perceived implication of lassa fever among residents of Oke-Ero Local Government Area, Kwara State Nigeria." Ghana Journal of Health, Physical Education, Recreation, Sports and Dance (GJOHPERSD) 10, no. 1 (2017): 42–57. http://dx.doi.org/10.47963/gjohpersd.v10i1.544.

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This study investigated the knowledge and perceived implication of Lassa fever among residents of Oke-Ero Local Government Area, Kwara State. The major occupation of the residents of Oke-Ero is farming. During the dry season, some farmers make use of bush burning method as a mean of clearing their lands, during which many of the rats from the bushes find their ways to neighbourhood houses to hide for safety. This gives them access to food stuffs kept by the residents. The purpose of the study was to investigate whether the residents of Oke-Ero Local Government Area, Kwara State have knowledge

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Ogwuche, Otache Innocent, and T. A. Emonyi. "DETERMINISTIC AND STOCHASTIC MODEL FOR THE TRANSMISSION OF LASSA FEVER." FUDMA JOURNAL OF SCIENCES 8, no. 1 (2024): 11–18. http://dx.doi.org/10.33003/fjs-2024-0801-2246.

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Many models on the transmission dynamics of Lasser fever were based on purely deterministic approach. This approach does not put into cognizance randomness which is inherent in disease transmission resulting from differences in immunity levels, contact patterns, hygienic practices and mutation rates among so many other possibilities. In this work, we attempt to demonstrate the impact of uncertainties in the mode of transmission of Lassa fever by subjecting the dynamics to some white noise modeled by the Brownian motion as a Wiener process. An existing deterministic model involving the Suscepti

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Farman, Muhammad, Cicik Alfiniyah, and Muhammad Saqib. "Global Stability with Lyapunov Function and Dynamics of SEIR-Modified Lassa Fever Model in Sight Power Law Kernel." Complexity 2024 (February 12, 2024): 1–27. http://dx.doi.org/10.1155/2024/3562684.

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Lassa fever is an acute viral hemorrhagic disease that affects humans and is endemic in various West African nations. In this study, a fractional-order model is constructed using the Caputo operator for SEIR-type Lassa fever transmission, including the control strategy. The proposed model examines the dynamics of Lassa fever transmission from rodents to humans and from person to person and in territories with infection in society. The model is analyzed both qualitatively and quantitatively. We examine the positively invariant area and demonstrate positive, bounded solutions to the model. We al

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Song, Isma’ila M., Abubakar A. Abubakar, Shu’aibu H. Bade, and Abdulmumini Husseini. "Mathematical Model for the Dynamics of Lassa Fever Incorporating Treatment and Isolation." International Journal of Development Mathematics (IJDM) 1, no. 3 (2024): 060–79. http://dx.doi.org/10.62054/ijdm/0103.05.

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Lassa Fever (Hemorrhagic Fever) is a widespread disease cause by Mastomys rodent and cause serious health problem leading to loss of lives. This research aims to analyze some existing with the intention of modifying or developing new one Mathematical Model for the Dynamics of Lassa Fever Incorporating Treatment and Isolation. We establish the positivity, boundedness, diseases free and endemic equilibria, basic reproduction number, local and global stability and carried out numerical simulation of the modified model. We formulate and analyze deterministic mathematical model of nine compartments

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Richmond, J. K. "Lassa fever: epidemiology, clinical features, and social consequences." BMJ 327, no. 7426 (2003): 1271–75. http://dx.doi.org/10.1136/bmj.327.7426.1271.

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Nkemnole E. B. and Oyewole J. O. "An Analysis of the Hidden Markov Model for Surveilling the Transmission of Lassa Fever Epidemic Disease in Nigeria during Dry Season." International Journal of TROPICAL DISEASE & Health 44, no. 18 (2023): 1–14. http://dx.doi.org/10.9734/ijtdh/2023/v44i181473.

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Lassa fever is an infectious viral disease that is endemic in Nigeria and other West African countries. Early detection and response to outbreaks of the disease are critical to prevent its spread and reduce illnesses and death. Finding some mathematical patterns that explain the mechanisms of Lassa fever transmission, as well as a thorough understanding of the biological contributing to affecting the disease, are necessary in putting in place a surveillance system with a view to preventing further spread of the disease. In this study, we developed a Hidden Markov Model (HMM) approach to survei

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Onyinyechi Favour, Anorue, and Okeke Anthony Anya. "Mathematical Model for Lassa Fever Transmission and Control." Mathematics and Computer Science 5, no. 6 (2020): 110. http://dx.doi.org/10.11648/j.mcs.20200506.13.

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MO, Durojaye, Ajie I J, and Popoola A O. "The Dynamics of Lassa Fever Transmission and Control." International Journal of Scientific Engineering and Research 5, no. 6 (2017): 71–74. https://doi.org/10.70729/ijser151554.

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Areji, Solomon Chetachukwu, Kelechi Raphael Onyenemezu, John Chiedu Ubah, et al. "Knowledge, Attitude and Prevention of Lassa fever Transmission among Women in Nnewi North Lga, Anambra State, Nigeria." International Journal of TROPICAL DISEASE & Health 44, no. 11 (2023): 27–44. http://dx.doi.org/10.9734/ijtdh/2023/v44i111439.

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Purpose: Lassa fever is a disease of public health concern associated with significant morbidity and mortality. It is noted to be endemic in the west-African Lassa fever belt with seasonal variations usually associated with epidemics. Nigeria among other countries is known to suffer from this. This study aims to determine the Knowledge, attitude, and prevention of Lassa Fever transmission among women in Nnewi North LGA of Anambra State and contributory factors. Methodology: A cross-sectional study conducted among women in Nnewi between 1st to 30th September, 2022. Data was collected usin

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Musa, Adesola, Kazeem Osuolale, Dayo Lawal, et al. "Modelling Seasonal Variation and Lassa Fever Outbreak in Nigeria: A Predictive Approach." International Journal of Data Science and Analysis 10, no. 5 (2024): 100–108. https://doi.org/10.11648/j.ijdsa.20241005.12.

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&lt;i&gt;Background&lt;/i&gt;: Lassa fever, a severe viral hemorrhagic fever caused by the Lassa virus, is a significant public health concern in West Africa, particularly in Nigeria. First identified in the 1950s, Lassa fever has been a persistent threat, causing outbreaks annually. This study investigates the temporal patterns and trends of Lassa fever outbreaks in Nigeria between 2017 and 2023, leveraging a comprehensive dataset from the Nigerian Centre for Disease Control (NCDC). &lt;i&gt;Objective&lt;/i&gt;: The goal of this study is to analyze the seasonal

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Ramzan, Yasir, Aziz Ullah Awan, Muhammad Ozair, Takasar Hussain, and Rahimah Mahat. "Innovative strategies for Lassa fever epidemic control: a groundbreaking study." AIMS Mathematics 8, no. 12 (2023): 30790–812. http://dx.doi.org/10.3934/math.20231574.

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<abstract><p>This study aims to develop a mathematical model for analyzing Lassa fever transmission dynamics and proposing effective control measures. The stability of the Lassa fever-free equilibrium point is examined and the model's accuracy is assessed using real-world data. Additionally, the parameter values and the basic reproduction number are estimated. A sensitivity analysis is also conducted, which identifies the key drivers influencing transmission dynamics. Moreover, the impact of model parameters on basic reproduction numbers is investigated. Multiple control methodolog

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