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Relevant bibliographies by topics / Late functionalization / Dissertations / Theses

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Dissertations / Theses on the topic 'Late functionalization'

Author: Grafiati

Published: 7 September 2024

Last updated: 31 July 2025

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1

Brown, Alec Nathaniel. "Late-Stage Functionalization of 1,2-Dihydro-1,2-Azaborines." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104564.

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Thesis advisor: Shih-Yuan Liu<br>Described herein are two distinct research projects focused on the development of metal-catalyzed late-stage functionalization strategies for 1,2-dihydro-1,2-azaborines separated into three chapters. The first chapter discusses the development, synthesis, and recent contributions to the field of azaborine chemistry. The second chapter details the development of rhodium catalyzed B-H bond activation for the synthesis of a new class of BN-stilbenes as well as the discovery of a novel B-H to B-Cl transformation that is successful both with B-H azaborines as well a

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2

Canelli, Tommaso. "Development of tandem C-H borylation/functionalization procedures for late stage functionalization of compounds." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9273/.

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The development of procedures for the iridium catalyzed C-H borylation of 1-aryl pyrazolopyrimidines and 1-aryl indazoles is reported. Investigation on the activity of the catalyst revealed the combination of an iridium (I) precursor and tetramethylphenantroline as the best catalytic system. Moreover, the procedures are regioselective resulting in the selective borylation of different C-H bonds within the substrates. The application of C-H borylation to late stage functionalization is demonstrated: a biologically active compound in AstraZeneca's project underwent tandem borylation/oxidation re

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3

Bentley, Sierra Kathleen. "Selective Direct Borylation and Late-Stage Functionalization of 1,2-Azaborines:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:109014.

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Thesis advisor: Shih-Yuan Liu<br>Described herein is the development of a method to directly borylate the C5-position of monocyclic 1,2-azaborines without the use of a metal catalyst, kinetic resolution or directing group. This method tolerates different substitution on the boron as well as at the C3-position of the azaborine. A new BN-isostere of the drug molecule, felbinac, was synthesized to demonstrate the application of this method<br>Thesis (MS) — Boston College, 2020<br>Submitted to: Boston College. Graduate School of Arts and Sciences<br>Discipline: Chemistry

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4

Kaplaneris, Nikolaos [Verfasser]. "Resource-Economical C–H Activation for Late-Stage Functionalization / Nikolaos Kaplaneris." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1237128854/34.

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5

Armand, Jeremy Richard. "Late Stage Functionalization of 1,2-Azaborines for Application in Biomedical Research:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108646.

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Thesis advisor: Shih-Yuan . Liu<br>Chapter 1. Use of boron as a pharmacophore is as growing but still underdeveloped strategy for expanding chemical space in biomedical research. In addition to more established methods of incorporating boron in drug development, an attractive and emerging method of introducing boron into biologically active compounds is through boron-nitrogen containing heterocycles. In particular, the Liu group has focused on exploring the interactions of monocyclic 1,2-azaborines in biological space. In order to install complicated chemical functionality needed for further s

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6

Chan, Jessica Zee. "Stereoselective Functionalization of Carbonyl Compounds and N-Alkylamines Promoted by Cooperative Catalysts:." Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108940.

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Thesis advisor: Masayuki Wasa<br>This dissertation describes the development of cooperative catalyst systems for the functionalization of monocarbonyl compounds and stereoselective transformations of alpha-C–H bonds of N-alkylamines, inspired by the concepts of frustrated Lewis pairs (FLPs). Prior to this dissertation research, practical and broadly applicable C–C and C–heteroatom bond forming reactions involving the FLP complexes that provide synthetically desirable products with high enantioselectivity remained to be developed. Chapter 1 of this dissertation describes the recent advances in

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7

Schischko, Alexandra. "Late-Stage Peptide Functionalization by Ruthenium-Catalyzed C H Arylations and Alkylations." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E4F4-0.

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8

Zhang, Zhuan. "Late Stage Modifications of Phosphines using Transition-Metal-Catalyzed C–H Bond Functionalization." Thesis, Rennes, Ecole nationale supérieure de chimie, 2020. http://www.theses.fr/2020ENCR0067.

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L'objectif principal de cette thèse de doctorat porte sur la préparation de phosphines polyfonctionnelles par diversification tardive de ligands commerciaux. Nous avons développé l'alkylation la liaison C–H en position ortho' des biarylphosphines catalysée par le rhodium(I). Cette nouvelle méthodologie permet d'accéder facilement à une vaste bibliothèque de phosphines multifonctionnelles. Certains de ces ligands modifiés ont surpassé les phosphines disponibles dans le commerce dans la carboxylation des bromures d'aryle catalysée par le palladium avec du dioxyde de carbone en présence d'un cata

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9

Poudel, Dhruba P. "Late-Stage Modification of Polyurethane Dendrimers Using Click Chemistry." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1627490978861964.

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10

Hanson, Susan Kloek. "Synthesis and reactivity studies of late transition metal complexes relevant to C-H bond activation and functionalization /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8631.

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11

Börgel, Jonas Verfasser], Tobias [Akademischer Betreuer] Ritter, and Franziska [Akademischer Betreuer] [Schönebeck. "Late-stage functionalization of arenes: from C-H amination to C-H oxygenation and deoxyfluorination / Jonas Börgel ; Tobias Ritter, Franziska Schoenebeck." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/121086293X/34.

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12

Sang, Ruocheng Verfasser], Tobias [Akademischer Betreuer] Ritter, and Carsten [Akademischer Betreuer] [Bolm. "Late-stage functionalization of arenes: site-selective C-H oxygenation and fluorination via aryl sulfonium salts / Ruocheng Sang ; Tobias Ritter, Carsten Bolm." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1221697455/34.

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13

Böhm, Marvin Jeldrik. "Synthesis and reactivity of succinylthioimidazolium salts: A unified strategy for the preparation of thioethers." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-152E-1.

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14

Zhu, Yingjun. "Sustainable Strategies for Site-Selective C–H Functionalizations of N-Heterocycles." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5DDA-D.

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15

Leroux, Marcel Rainer [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Late-stage functionalization of peptides and cyclopeptides using organozinc reagents and pyrrole protected 2-Aminoalkylzinc reagents for the enantioselective synthesis of amino derivatives / Marcel Rainer Leroux ; Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1208150057/34.

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16

Schischko, Alexandra [Verfasser], Lutz [Akademischer Betreuer] Ackermann, Lutz [Gutachter] Ackermann, et al. "Late-Stage Peptide Functionalization by Ruthenium-Catalyzed C H Arylations and Alkylations / Alexandra Schischko ; Gutachter: Lutz Ackermann, Dietmar Stalke, Manuel Alcarazo, Franziska Thomas, Shoubhik Das, Alexander Breder ; Betreuer: Lutz Ackermann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1170955819/34.

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17

Mamontov, Alexander. "Hydroxylation et halogénation directe et sélective des composés azotés en milieu superacide." Thesis, Poitiers, 2018. http://www.theses.fr/2018POIT2267.

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La fonctionnalisation tardive de molécules (Late stage functionalization – LSF) offre l’opportunité d’explorer l’espace chimique plus efficacement, en particulier en considérant les liaisons C-H aromatiques comme des points potentiels de diversification pour générer de nouveaux analogues directement en une seule étape au lieu de faire une synthèse totale dite de novo. La fonctionnalisation directe de composés élaborés peut en particulier se faire en utilisant la technologie superacide comme démontré par les nombreux travaux du professeur Jacquesy. L’un des meilleurs exemples de cette stratégie

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18

Panza, Florian. "Fοnctiοnnalisatiοn directe οrthοgοnale métallο-catalysée des sites carbοne-hydrοgène des platefοrmes pharmacοlοgiques à cοeur imidazοisοindοle". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMIR11.

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Depuis quelques décennies, les chimistes cherchent à toujours repousser les limites des stratégies de synthèse en développant des méthodologies toujours plus efficaces, plus simples et plus économes. Dans ce contexte, la fonctionnalisation directe de liaisons C—H catalysée par des métaux de transition constitue l’un des outils les plus puissants pour construire et fonctionnaliser des molécules simples mais aussi des édifices moléculaires de plus en plus complexes, avec une grande diversité de liaisons C—H, ces stratégies répondant également aux besoins actuels d’ouverture de l’espace chimique

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19

Zakis, Janis Mikelis. "Catalyseurs d'iridium cyclométallés pour la borylation ortho-dirigée de C–H." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF006.

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Au cours des deux dernières décennies, la borylation C–H a continué d'évoluer, passant des premiers exemples de réactions stœchiométriques à la synthèse de blocs de construction à l'échelle du kilogramme.1 Plus récemment, l'accent a été mis sur la borylation dirigée permettant un meilleur contrôle de la régiosélectivité dans des molécules plus complexes (Figure 1B).2,3 Généralement, cela est réalisé par une conception astucieuse du ligand introduisant des groupements chélateurs sur le ligand permettant l'interaction ligand-groupe directeur du matériau de départ (Figure 1A, II). La deuxième app

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20

Jamshaid, Talha. "Synthèse de latex magnétique submicronique et fonctionnalisé pour application en biocapteur." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1061/document.

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L'objectif de ce travail est de surmonter tous ces processus long et fastidieux comme la filtration et la centrifugation qui sont utilisées dans l'application in-vitro. En plus, ces particules qui sont appropriés pour une utilisation dans le laboratoire-sur une-puce et les biocapteurs systèmes sont produites. Les particules submicroniques magnétiques de latex (MLPs) avec la morphologie noyaucoque souhaité ont été préparées. L'huile dans eau (h/e) et l'émulsion magnétique (faitmaison) a été utilisé en tant que graine de polymérisation radicalaire en émulsion de styrène (St) en tant que monomère

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21

LENCI, ELENA. "Diversity-Oriented Synthesis of novel glyco- and peptidomimetic scaffolds." Doctoral thesis, 2017. http://hdl.handle.net/2158/1091042.

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After an impressive growth at the end of the last century, the number of new molecular entities launched on the market dramatically decreased in recent years. Thus, there is a need for efficient synthetic processes capable of generating an high number of different molecules, which differ not only for the appendages, but also for the molecular skeleton. In this context, Diversity-Oriented Synthesis (DOS) has proved to be very effective in the achievement of high quality small molecules collections for high-throughput screening and phenotypic assays and chemical genetics studies, leading to the

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22

Zheng, Lei. "Noncovalent Functionalization of Latex Particles using High Molecular Weight Surfactant for High-Performance Coatings." 2019. https://scholarworks.umass.edu/masters_theses_2/813.

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The expected outcome of this project is to develop a general strategy to functionalize dispersions, by noncovalent adsorption of HMW surfactants, ultimately for applications such as hydrophobic coatings with high hiding power and hardness, improved mechanical properties via pigment-latex interactions, improved substrate adhesion or improved freeze-thaw stability. So far, we have produced poly (methyl methacrylate-co-butyl acrylate) latexes in the presence of HMW surfactants via emulsion polymerization and demonstrated stronger adsorption of HMW surfactants on particle surface than sodium dodec

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