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Journal articles on the topic 'Latent tuberculous infection'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Yun, Joon S., Angeline A. Lazarus, and Russell Gilbert. "Latent Tuberculous Infection." Disease-a-Month 52, no. 11-12 (2006): 441–45. http://dx.doi.org/10.1016/j.disamonth.2006.09.009.

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2

Flynn, JoAnne L., Charles A. Scanga, Kathryn E. Tanaka, and John Chan2. "Effects of Aminoguanidine on Latent Murine Tuberculosis." Journal of Immunology 160, no. 4 (1998): 1796–803. http://dx.doi.org/10.4049/jimmunol.160.4.1796.

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Abstract A unique feature of Mycobacterium tuberculosis is its ability to establish latent infection in the human host, which can reactivate to cause disease years later. In the present study, the mechanisms involved in the control of latent tuberculous infection were examined using two murine experimental tuberculosis models. Analysis of the model involving infection of mice with a relatively low inoculum of the virulent Erdman strain of M. tuberculosis indicated that in vivo inhibition of reactive nitrogen intermediate (RNI) production by the nitric oxide synthase inhibitor aminoguanidine re

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3

BARMINA, N. A., L. A. BARYSHNIKOVA, A. A. SHURYGIN, and V. V. REYKHARDT. "LATENT TUBERCULOUS INFECTION SCREENING RECOMBINANT TUBERCULOUS ALLERGEN." Tuberculosis and lung diseases 94, no. 5 (2016): 56–60. http://dx.doi.org/10.21292/2075-1230-2016-94-5-56-60.

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4

Collins, Lauren F., Carolina Geadas, and Jerrold J. Ellner. "Diagnosis of Latent Tuberculous Infection." Annals of Internal Medicine 165, no. 6 (2016): 448. http://dx.doi.org/10.7326/l16-0192.

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5

Crawford, Colin L. "Diagnosis of Latent Tuberculous Infection." Annals of Internal Medicine 165, no. 6 (2016): 447. http://dx.doi.org/10.7326/l16-0193.

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6

Bailey, Thomas C. "Diagnosis of Latent Tuberculous Infection." Annals of Internal Medicine 165, no. 6 (2016): 447. http://dx.doi.org/10.7326/l16-0194.

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7

Sakhelashvili, M. I., Z. I. Piskur, O. I. Sakhelashvili–Bil, et al. "Application of BI-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection: evaluation of effectiveness." Tuberculosis, Lung Diseases, HIV Infection, no. 1 (March 15, 2023): 37–43. http://dx.doi.org/10.30978/tb-2023-1-37.

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Objective — to study the need of using the natural immunomodulator ВІ-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection (MDR-TBI) for a non-specific immunoprevention of tuberculosis (TB). Materials and methods. A retrospective analysis of the medical records of 120 contacts (75 children and 45 adolescents) from focies of MDR-TBI and 102 adult with TB, who became the source of infection was carried out. Microbiological examination in adults included the detection of Mycobacterium tuberculosis (MBT) in sputum by smear microscopy, sowing of material o

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8

Krishna, Kavita, Sachin Adukia, and Ayantika Dhara. "Lurking in the Dark: Latent Tuberculosis Infection." International Journal of Medical and Dental Sciences 3, no. 1 (2014): 369. http://dx.doi.org/10.19056/ijmdsjssmes/2014/v3i1/80731.

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A subset of the tuberculous population has latent tuberculosis infection (LTBI). It is a condition wherein the affected individual is infected with Mycobacterium tuberculosis, but does not have any signs or symptoms of tuberculosis nor is he infectious to others. Risk of progression to active tuberculous infection is influenced by co-morbidities like HIV, diabetes, malignancy requiring chemotherapy, infants and children in close contact with susceptible individuals, and healthcare workers. Early diagnosis of LTBI is paramount. In addition to tuberculin test, Interferon gamma release assay (IGR

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9

Lim, Sung Chul, Juhee Oh, Jeonghyun Park, Sanghyun Kim та Jusuck Lee. "False-negative interferon-γ release assay result in an elderly patient with tuberculous meningitis". Journal of Geriatric Neurology 2, № 2 (2023): 81–84. http://dx.doi.org/10.53991/jgn.2023.00108.

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Tuberculous meningitis (TBM) is the most severe manifestation of extra-pulmonary tuberculosis, and has high morbidity and mortality. Therefore early treatment, which is empirical therapy, is essential to improve the clinical prognosis of TBM. But rapid diagnosis remains a challenge due to non-specific symptoms, low sensitivity and time-comsuming diagnostic tests. Mycobacterium tuberculosis antigen specific interferon-γ release assay (IGRA) is widely considered as an adjunctive test to confirm latent tuberculous infection or to support the diagnosis of active tuberculous infection. However, eld

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10

Tyulkova, Tatyana Y., and Alesya V. Mezentseva. "Latent Tuberculosis Infection and Residual Post-Tuberculous Changes in Children." Current pediatrics 16, no. 6 (2017): 452–56. http://dx.doi.org/10.15690/vsp.v16i6.1817.

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11

Khan, Shazma, Crystal Ike, Jeff Dennis, and Kenneth Nugent. "The prevalence and characteristics of adults with latent tuberculous infection in the United States and the implications for healthcare in Texas." Southwest Respiratory and Critical Care Chronicles 9, no. 39 (2021): 53–62. http://dx.doi.org/10.12746/swrccc.v9i39.847.

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The Centers for Disease Control and Prevention reported 8,916 cases of tuberculosis in 2019. Reducing the number of cases of active tuberculosis requires identification of patients with latent tuberculous infections (LTBI). Optimal screening for LTBI requires information about the demographics and characteristics of people who are more likely to have had tuberculous infection. Information from the 2011–2012 National Health and Nutrition Examination Survey (NHANES) was used to determine the number and characteristics of adults from a representative sample of the United States who had LTBI. Late

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12

Cisneros, Jennifer R., and Kim M. Murray. "Corticosteroids in Tuberculosis." Annals of Pharmacotherapy 30, no. 11 (1996): 1298–303. http://dx.doi.org/10.1177/106002809603001115.

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OBJECTIVE: TO examine the effects of corticosteroids used for concomitant disease states in patients with latent or active tuberculosis (TB). The role of corticosteroids in the treatment of extrapulmonary TB is also discussed. DATA SOURCES: A MEDLINE search was conducted for the years 1953-1995. The International Pharmaceutical Abstracts service was also used to conduct an extensive literature review. In addition, relevant articles were cross-referenced to screen for additional information. STUDY SELECTION/DATA EXTRACTION: During the literature review, emphasis was placed on human studies and

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13

Khalafova, E. T., and E. M. Bogorodskaya. "Prevalence of Latent Tuberculosis Infection among Residents of Social Housing." Tuberculosis and Lung Diseases 102, no. 5 (2024): 6–11. http://dx.doi.org/10.58838/2075-1230-2024-102-5-6-11.

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The objective: to assess the prevalence of latent tuberculosis infection among people living in social housing.Subjects and Methods. Prevalence of latent tuberculosis infection (LTBI) was analyzed among residents of two social homes in Moscow; totally 936 people were examined. These individuals were given a skin test with the tuberculous recombinant allergen (TRA). To exclude tuberculosis, those with a positive response underwent examination and tests including chest computed tomography and 3 consecutive sputum smears for acid-fast mycobacteria. If tuberculosis was ruled out according to the r

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14

McShane, Helen. "Co-infection with HIV and TB: double trouble." International Journal of STD & AIDS 16, no. 2 (2005): 95–101. http://dx.doi.org/10.1258/0956462053057576.

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Co-infection with HIV and Mycobacterium tuberculosis is common, particularly in the developing world. Tuberculosis (TB) is the commonest co-infection in HIV-positive individuals, who are at increased risk of both reactivation of latent infection and acquisition of new infection. As the degree of immunosuppression increases, the risks of developing TB disease also increase. The patho-physiology, clinical picture, differential diagnosis and diagnostic tests are discussed, together with the interactions between antiretroviral therapy and anti-tuberculous chemotherapy. Indications for chemoprophyl

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15

Krusiński, Adam, Anna Grzywa-Celińska, Katarzyna Szewczyk, Luiza Grzycka-Kowalczyk, Justyna Emeryk-Maksymiuk, and Janusz Milanowski. "Various Forms of Tuberculosis in Patients with Inflammatory Bowel Diseases Treated with Biological Agents." International Journal of Inflammation 2021 (January 5, 2021): 1–8. http://dx.doi.org/10.1155/2021/6284987.

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Although there are undeniable advantages of treatment of the inflammatory bowel diseases, Crohn’s disease, and ulcerative colitis, with biological agents, the increased susceptibility to tuberculosis should not be ignored. Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis complex which includes M. tuberculosis, M. bovis, and M. africanum. Primary tuberculosis is uncommon in the setting of inflammatory bowel disease: reactivation of latent tuberculosis is of greater concern. Consequently, latent infection should be excluded in patients who qualify for immunosuppress

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16

Usmanov, I. V. "Errors in the diagnosis of tuberculous spondylitis." Kazan medical journal 70, no. 3 (1989): 188–90. http://dx.doi.org/10.17816/kazmj99857.

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From 1983 to 1986, 42 patients (25 men and 17 women) with tuberculous spondylitis were treated in the department of bone and joint tuberculosis at the Almetyevsk Anti-Tuberculosis Dispensary. Two patients were under the age of 18, 15 patients were between 19 and 40, 17 patients were between 41 and 60, and 8 patients were older than 61. These data do not agree with the idea that children are predominantly affected by this disease. We attribute tuberculous spondylitis detected in our patients at an older and elderly age to the exacerbation of latent infection suppressed in their childhood.

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17

Scanga, Charles A., V. P. Mohan, Keming Yu та ін. "Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2". Journal of Experimental Medicine 192, № 3 (2000): 347–58. http://dx.doi.org/10.1084/jem.192.3.347.

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Tuberculosis is a major cause of death in much of the world. Current estimates are that one-third of the world's population is infected with Mycobacterium tuberculosis. Most infected persons control the infection but in many cases may not eliminate the organism. Reactivation of this clinically latent infection is responsible for a large proportion of active tuberculosis cases. A major risk factor for reactivation of latent tuberculosis is HIV infection, suggesting a role for the CD4+ T cell subset in maintaining the latent persistent infection. In this study, we tested the requirement for CD4+

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18

Awil, PO, SJ Bowlin, and TM Daniel. "Radiology of pulmonary turberculosis and human immunodeficiency virus infection in Gulu, Uganda." European Respiratory Journal 10, no. 3 (1997): 615–18. http://dx.doi.org/10.1183/09031936.97.10030615.

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Pulmonary tuberculosis is a major complication of human immunodeficiency virus (HIV) infection. The radiographic manifestations of pulmonary tuberculosis in HIV-infected patients are not typical of those seen in immunologically normal individuals. We sought to determine whether these manifestations provide clues to the pathogenesis of tuberculosis in HIV-infected persons. The radiographic manifestations of pulmonary tuberculosis were reviewed and classified in 82 HIV-positive and 53 HIV-negative tuberculous patients in Gulu, Uganda. Pulmonary presentations of tuberculosis were more acute in HI

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19

Tyulkova, T. E., O. V. Kosareva, S. N. Skornyakov, and O. V. Fadina. "SPECIFIC FEATURES OF LATENT TUBERCULOUS INFECTION DIAGNOSTICS AMONG CHILDREN." Tuberculosis and Lung Diseases 96, no. 6 (2018): 67–68. http://dx.doi.org/10.21292/2075-1230-2018-96-6-67-68.

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20

Shieh, Fred K., Graham Snyder, C. Robert Horsburgh, John Bernardo, Claire Murphy, and Jussi J. Saukkonen. "Predicting Non-Completion of Treatment for Latent Tuberculous Infection." American Journal of Respiratory and Critical Care Medicine 174, no. 6 (2006): 717–21. http://dx.doi.org/10.1164/rccm.200510-1667oc.

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21

Kim, Jong-Hyun. "Treatment of latent tuberculous infection in children and adolescent." Korean Journal of Pediatrics 52, no. 5 (2009): 519. http://dx.doi.org/10.3345/kjp.2009.52.5.519.

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22

Mullins, J., M. N. Lobato, K. Bemis, and L. Sosa. "Spatial clusters of latent tuberculous infection, Connecticut, 2010–2014." International Journal of Tuberculosis and Lung Disease 22, no. 2 (2018): 165–70. http://dx.doi.org/10.5588/ijtld.17.0223.

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23

Chakravarty, Soumya D., Guofeng Zhu, Ming C. Tsai, et al. "Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs." Infection and Immunity 76, no. 3 (2008): 916–26. http://dx.doi.org/10.1128/iai.01011-07.

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ABSTRACT Tumor necrosis factor (TNF) is a prototypic proinflammatory cytokine that contributes significantly to the development of immunopathology in various disease states. A complication of TNF blockade therapy, which is used increasingly for the treatment of chronic inflammatory diseases, is the reactivation of latent tuberculosis. This study used a low-dose aerogenic model of murine tuberculosis to analyze the effect of TNF neutralization on disease progression in mice with chronic tuberculous infections. Histological, immunohistochemical, and flow cytometric analyses of Mycobacterium tube

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24

Theodore, C. M., G. E. Forster, B. T. Goh, N. Barnes, and D. Hughes. "Screening for Tuberculosis in an East London HIV Clinic." International Journal of STD & AIDS 5, no. 6 (1994): 432–35. http://dx.doi.org/10.1177/095646249400500610.

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A prospective study was carried out to assess the value of routine skin tuberculin testing and chest radiography in HIV seropositive patients, attending the Genitourinary Medicine (GUM) clinic between July 1991–May 1992. 144 consecutive HIV seropositive patients had tuberculin Tine tests and chest radiographs performed. Ten patients were treated for active tuberculosis (TB) on the basis of abnormal radiography with or without strongly positive (Grade 3/4) skin tuberculin tests. A further 10 patients received prophylaxis on the basis of abnormal chest radiography consistent with previous tuberc

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25

Margolis, B., H. A. A. Al-Darraji, J. A. Wickersham, A. Kamarulzaman, and F. L. Altice. "Prevalence of tuberculosis symptoms and latent tuberculous infection among prisoners in northeastern Malaysia." International Journal of Tuberculosis and Lung Disease 17, no. 12 (2013): 1538–44. http://dx.doi.org/10.5588/ijtld.13.0193.

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26

Fox, G. J., N. T. Anh, N. V. Nhung, et al. "Latent tuberculous infection in household contacts of multidrug-resistant and newly diagnosed tuberculosis." International Journal of Tuberculosis and Lung Disease 21, no. 3 (2017): 297–302. http://dx.doi.org/10.5588/ijtld.16.0576.

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27

Hoffmann, H., A. Bosse, A. Neher, and M. Singh. "P2004 Serological rapid test for discrimination between latent tuberculous infection and active tuberculosis." International Journal of Antimicrobial Agents 29 (March 2007): S576—S577. http://dx.doi.org/10.1016/s0924-8579(07)71843-5.

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28

Eralieva, L. T., K. S. Serikbaeva, A. S. Rakisheva, Z. S. Bekbenbetova, and O. G. Prikhodchenko. "Improvement of Organizational Measures for Detection and Diagnosing of Tuberculous Infection and Tuberculosis in Adolescents in the Republic of Kazakhstan." Tuberculosis and Lung Diseases 102, no. 1 (2024): 46–51. http://dx.doi.org/10.58838/2075-1230-2024-102-1-46-51.

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The objective: to improve organizational measures for detection and diagnosing of tuberculous infection and tuberculosis in adolescents in the Republic of Kazakhstan.Subjects and Methods. Screening was conducted among 27,648 adolescents aged 15-17 years from regions of the Republic of Kazakhstan with a high burden of tuberculosis. It was planned to use TRA tests and fluorography in parallel, while local doctors, district and school nurses, and nurses in vaccination rooms were preliminary trained by pediatric phthisiologists to perform the test, evaluate its results and monitor manifestations o

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Prylutskyi, OS S., and YuD D. Rogovaya. "METHODS OF SPECIFIC DIAGNOSIS OF TUBERCULOSIS: A MODERN VIEW ON THE PROBLEM." Science and Innovations in Medicine 2, no. 2 (2017): 44–51. http://dx.doi.org/10.35693/2500-1388-2017-0-2-44-51.

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This review presents modern views on the problems of immunodiagnosis of tuberculosis. We have examined the advisability of the use of immunological methods for diagnosis of active tuberculosis and detection of latent tuberculous infection. It is shown that nowadays the use of serological diagnostic methods is not recommended because of contradictory information about their accuracy and limited diagnostic significance. Advantages and disadvantages of current methods of assessment of cell-mediated immune response that are used as screening tests for diagnosis of latent tuberculosis have been ana

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Chen, Xinchun, Mingxia Zhang, Mingfeng Liao, and Boping Zhou. "Suppressive Th17 responses in patients with active tuberculosis is associated with reduced IL-6R expression on CD4+ T cells (37.51)." Journal of Immunology 184, no. 1_Supplement (2010): 37.51. http://dx.doi.org/10.4049/jimmunol.184.supp.37.51.

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Abstract The frequencies of IFN-γ-, IL-4-, IL-17-, FoxP3- and IL-6R- expressing CD4+ T cells in blood and/or pleural effusion sample of healthy donors, subjects with latent tuberculosis infection and patients with active tuberculosis, were analyzed by flow cytometry. The frequency of Th17 cells in patients with active tuberculosis is significantly lower than those in healthy donors and individuals with latent tuberculosis infection. The reduction of Th17 response was significantly more profound in patients with severe tuberculosis disease compared to those with pulmonary tuberculosis only. The

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31

Jain, Ruchika K., Amit R. Nayak, Aliabbas A. Husain, et al. "Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis." Disease Markers 35 (2013): 311–16. http://dx.doi.org/10.1155/2013/309816.

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The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein ofMycobacterium tuberculosis(MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n=31), suspected latent TBM (n=22), and suitable noninfectious control subjects (n=47) were collected and evaluated for Rv2623 antigen level using ELISA protocol. A significantly high (P<0.05) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients. However, no significant differen

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32

Denholm, J. T., A. Matteelli, and A. Reis. "Latent tuberculous infection: ethical considerations in formulating public health policy." International Journal of Tuberculosis and Lung Disease 19, no. 2 (2015): 137–40. http://dx.doi.org/10.5588/ijtld.14.0543.

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33

Tan, Wan C. "Low body mass index and latent tuberculous infection: current evidence?" International Journal of Tuberculosis and Lung Disease 22, no. 4 (2018): 355. http://dx.doi.org/10.5588/ijtld.18.0070.

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34

Halabitska, Iryna, Pavlo Petakh, Valentyn Oksenych, and Oleksandr Kamyshnyi. "Reactivation of Latent Tuberculosis Following COVID-19 and Epstein-Barr Virus Coinfection: A Case Report." Pathogens 14, no. 5 (2025): 488. https://doi.org/10.3390/pathogens14050488.

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Background: This case is unique in demonstrating the reactivation of latent tuberculosis (TB) following co-infection with SARS-CoV-2 and Epstein–Barr virus (EBV) in an otherwise healthy young adult. It highlights a rare clinical scenario in which viral immune dysregulation likely facilitated TB progression. To date, few reports have explored the complex interplay between COVID-19, EBV reactivation, and TB in a single patient, particularly with isolated extrapulmonary involvement. Case Presentation: A 24-year-old woman presented with persistent low-grade fever, fatigue, night sweats, unintentio

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35

ARRIAGA, A. K., E. H. OROZCO, L. D. AGUILAR, G. A. W. ROOK, and R. HERNÁNDEZ PANDO. "Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis." Clinical & Experimental Immunology 128, no. 2 (2002): 229–37. http://dx.doi.org/10.1046/j.1365-2249.2002.01832.x.

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36

Zenner, D., H. Hafezi, J. Potter, S. Capone, and A. Matteelli. "Effectiveness and cost-effectiveness of screening migrants for active tuberculosis and latent tuberculous infection." International Journal of Tuberculosis and Lung Disease 21, no. 9 (2017): 965–76. http://dx.doi.org/10.5588/ijtld.16.0935.

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37

Baronova, O. D., V. A. Aksenova, E. F. Luginova, and E. N. Dolzhenko. "The Use of Rifapentine for Preventive Chemotherapy in Children from Risk Groups of Developing Tuberculosis." Tuberculosis and Lung Diseases 100, no. 8 (2022): 31–36. http://dx.doi.org/10.21292/2075-1230-2022-100-8-31-36.

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The objective: to compare efficacy of preventive treatment of children with latent tuberculosis infection using various regimens of anti-tuberculosis drugs and assess the risk of adverse events to these drugs.Subjects and Methods. 117 children of 2-17 years old with latent tuberculosis infection [a positive result of the test with tuberculous recombinant allergen (TRA)] were enrolled in the prospective study. They received preventive treatment with the regimen containing isoniazid and rifapentine. The comparison group included 84 children who received isoniazid and rifampicin.Results. In terms

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38

Izzo, Carmine, Annunziata Monica, Giuseppe De Matteis, et al. "Not Only COVID-19: Prevalence and Management of Latent Mycobacterium Tuberculosis Infection in Three Penitentiary Facilities in Southern Italy." Healthcare 10, no. 2 (2022): 386. http://dx.doi.org/10.3390/healthcare10020386.

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Latent Mycobacterium tuberculosis infection (LTBI) and active tuberculosis in prisoners are higher than the general population and are two public health concerns, especially in low- and middle-income countries. We conducted a cross-sectional study to determine the prevalence and the factors associated with LTBI among the inmate population detained in three Southern Italian penitentiaries. Tuberculin intradermal reaction skin test was performed on the inmates who agreed to participate in the study. In case of positivity, the QuantiFERON-TB test was performed. In those positive to QuantiFERON, c

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39

Win, Kyaw Zin, Afshin Hamidi, Alamgir Sattar, and Abhijana Karunakaran. "Tuberculous Thyroiditis Post COVID-19 Infection." Journal of the Endocrine Society 5, Supplement_1 (2021): A970—A971. http://dx.doi.org/10.1210/jendso/bvab048.1983.

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Abstract Thyroid tuberculosis (TT) is a rare disease and can be a diagnostic challenge. Here we highlight a case of TT following COVID-19 infection. A 38-year Myanmar immigrant female presented with nocturnal fever, fatigue, nausea, sore throat, appetite and weight loss for 1 week with dysphagia, neck swelling, dyspnea, and watery diarrhea. Medical history included renal transplant due to ESRD from IgA nephropathy, DM and treated latent TB with no prior or family history of thyroid disease. She had COVID 7 months ago, complicated by allograft rejection. She was tachycardic, febrile but not in

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40

Bozhkov, I. A., M. A. Sevastyanov, I. Yu Silidi, N. V. Korneva, and S. A. Sterlikov. "Tuberculosis Infection Risk Areas in a Big Urban Center: Boundaries, Objects, Parameters, and Models." Tuberculosis and Lung Diseases 102, no. 5 (2024): 30–39. http://dx.doi.org/10.58838/2075-1230-2024-102-5-30-39.

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The objective: to build up models for the areas of infectious risk of tuberculosis spread in a big urban center, to evaluate the presence of objects and parameters influencing the probability of development of tuberculosis infection nudi.Subjects and Methods. A retrospective and prospective study was conducted from January 2021 to June 2022 in St. Petersburg TB Dispensary no. 5. The study was performed taking into account the results of field surveys, with subsequent processing of materials for the territory of Kalininskiy and Krasnogvardeyskiy Administrative Districts of St. Petersburg.Result

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Wortham, J. M., M. Goggin, C. Mora, L. Vandehey, L. Manangan, and K. M. Powell. "Acute kidney injury during treatment for latent tuberculous infection with rifampin." International Journal of Tuberculosis and Lung Disease 21, no. 5 (2017): 596–97. http://dx.doi.org/10.5588/ijtld.17.0003.

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42

Macaraig, M. M., M. Jalees, C. Lam, and J. Burzynski. "Improved treatment completion with shorter treatment regimens for latent tuberculous infection." International Journal of Tuberculosis and Lung Disease 22, no. 11 (2018): 1344–49. http://dx.doi.org/10.5588/ijtld.18.0035.

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43

N. S., Hochberg, R. W. Kubiak, A. Tibbs, et al. "Effectiveness of reporting on latent tuberculous infection in Massachusetts, 2006-2008." Public Health Action 4, no. 1 (2014): 53–55. http://dx.doi.org/10.5588/pha.13.0085.

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44

Ufimtseva, Elena. "Differences betweenMycobacterium-Host Cell Relationships in Latent Tuberculous Infection of MiceEx Vivoand Mycobacterial Infection of Mouse CellsIn Vitro." Journal of Immunology Research 2016 (2016): 1–21. http://dx.doi.org/10.1155/2016/4325646.

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The search for factors that account for the reproduction and survival of mycobacteria, including vaccine strains, in host cells is the priority for studies on tuberculosis. A comparison of BCG-mycobacterial loads in granuloma cells obtained from bone marrow and spleens of mice with latent tuberculous infection and cells from mouse bone marrow and peritoneal macrophage cultures infected with the BCG vaccinein vitrohas demonstrated that granuloma macrophages each normally contained a single BCG-Mycobacterium, while those acutely infectedin vitrohad increased mycobacterial loads and death rates.

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45

OKADA, K., T. E. MAO, T. MORI, et al. "Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children." Epidemiology and Infection 136, no. 9 (2007): 1179–87. http://dx.doi.org/10.1017/s0950268807009831.

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SUMMARYNewly developed interferon-gamma release assays have become commercially available to detect tuberculosis (TB) infection in adults. However, little is known about their performance in children. We compared test results between the QuantiFERON-TB® Gold test (QFT) and tuberculin skin test (TST) in young children living with pulmonary TB patients in Cambodia. Of 195 children tested with both QFT and TST, the TST-positive rate of 24% was significantly higher than the QFT-positive rate of 17%. The agreement between the test results was considerable (κ-coefficient 0·63). Positive rates increa

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Peremot, SD, LA Suhanova, MV Smilyanska, NV Kashpur, and AO Chernogrebel. "Combination of pulmonary tuberculosis and herpetic infection children." Annals of Mechnikov Institute, no. 3 (September 10, 2021): 17–20. https://doi.org/10.5281/zenodo.5499597.

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<strong>Introduction.</strong> The WHO estimates that millions of children become infected with Mycobacterium tuberculosis each year, and more than a million develop tuberculosis (TB). Most children are able to immunologically contain or neutralize the pathogen without developing pathology. Our country ranks 4th in the world in the incidence of adult tuberculosis, and fifth in the incidence of children among 53 regions controlled by the WHO European Office. The average estimated incidence of children in Ukraine is 37.4 per 100 thousand children, and exceeds the official figure by 4.5 times. <s

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Ufimtseva, Elena. "Mycobacterium-Host Cell Relationships in Granulomatous Lesions in a Mouse Model of Latent Tuberculous Infection." BioMed Research International 2015 (2015): 1–16. http://dx.doi.org/10.1155/2015/948131.

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Tuberculosis (TB) is a dangerous infectious disease characterized by a tight interplay between mycobacteria and host cells in granulomatous lesions (granulomas) during the latent, asymptomatic stage of infection.Mycobacterium-host cell relationships were analyzed in granulomas obtained from various organs of BALB/c mice with chronic TB infection caused byin vivoexposure to the Bacillus Calmette-Guérin (BCG) vaccine. Acid-fast BCG-mycobacteria were found to be morphologically and functionally heterogeneous (in size, shape, and replication rates in colonies) in granuloma macrophages, dendritic c

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National Tuberculosis Advisory Committee. "Position statement on interferon-γ release assays in the detection of latent tuberculosis infection". Communicable Diseases Intelligence 36 (1 березня 2012): 125–31. https://doi.org/10.33321/cdi.2012.36.8.

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In vitro T-cell based interferon-y (IFN-y) release assays (IGRAs), the QuantiFERON-TB Gold In-Tube test (QFN-GIT) (Cellestis Limited, Carnegie, Victoria, Australia) and the T-SPOT.TB test (T-Spot) (Oxford Immunotec Limited, Abingdon, United Kingdom), are marketed as a substitute for the tuberculin skin test (TST). The specificity of these immunoassays has been optimised by using Mycobacterium tuberculosis-specific antigens. IGRAs are more specific in patients with previous Bacille Calmette-Guérin (BCG) immunisation or exposure to non-tuberculous mycobacteria (NTM).There have been a plethora of

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Gupta, Kuldeepkumar Ramnaresh, Gunjan Arora, Abid Mattoo, and Andaleeb Sajid. "Stringent Response in Mycobacteria: From Biology to Therapeutic Potential." Pathogens 10, no. 11 (2021): 1417. http://dx.doi.org/10.3390/pathogens10111417.

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Mycobacterium tuberculosis is a human pathogen that can thrive inside the host immune cells for several years and cause tuberculosis. This is due to the propensity of M. tuberculosis to synthesize a sturdy cell wall, shift metabolism and growth, secrete virulence factors to manipulate host immunity, and exhibit stringent response. These attributes help M. tuberculosis to manage the host response, and successfully establish and maintain an infection even under nutrient-deprived stress conditions for years. In this review, we will discuss the importance of mycobacterial stringent response under

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Thrupp, Lauri, Suzanne Bradley, Philip Smith, et al. "Tuberculosis Prevention and Control in Long-Term–Care Facilities for Older Adults." Infection Control & Hospital Epidemiology 25, no. 12 (2004): 1097–108. http://dx.doi.org/10.1086/502350.

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AbstractIn the United States, older adults comprise 22% of cases of tuberculous disease but only 12% of the population. Most cases of tuberculosis (TB) occur in community dwellers, but attack rates are highest among frail residents of long-term–care facilities. The detection and treatment of latent TB infection and TB disease can pose special challenges in older adults. Rapid recognition of possible disease, diagnosis, and implementation of airborne precautions are essential to prevent spread. It is the intent of this evidence-based guideline to assist healthcare providers in the prevention an

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